569PRSS3F - Protein Fateextracellular regionTASextracellular spaceIDAextracellular exosomeIDAcobalamin metabolic processTASvitamin metabolic processTASendothelial cell migrationIMPinnate immune responseTASdigestionTASproteolysisIDAwater-soluble vitamin metabolic processTASsmall molecule metabolic processTASzymogen activationIDAserine-type endopeptidase activityIDAcalcium ion bindingIDAserine-type peptidase activityIDATrypsin-3; 3.4.21.4; Brain trypsinogen; Mesotrypsinogen; Serine protease 3; Serine protease 4; Trypsin III; Trypsin IV; Precursor11827488120217761450790915164053154893341992413423262018294000TRY3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3PRSS3Trypsin-3 3.4.21.4 Brain trypsinogen Mesotrypsinogen Serine protease 3 Serine protease 4 Trypsin III Trypsin IV Precursor181TCF12T - TranscriptioncytoplasmIDAnuclear chromatinIDARNA polymerase II transcription factor complexIDAnucleusIDAimmune responseTASmuscle organ developmentTASregulation of transcription from RNA polymerase II promoterTASpositive regulation of neuron differentiationIEApositive regulation of transcription from RNA polymerase II promoterIDAtranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingIDAtranscription factor activity, sequence-specific DNA bindingIDAbHLH transcription factor bindingIPIE-box bindingIEASMAD bindingIPIRNA polymerase II core promoter proximal region sequence-specific DNA bindingIDAenhancer bindingICtranscription factor bindingIPITranscription factor 12; TCF-12; Class B basic helix-loop-helix protein 20; bHLHb20; DNA-binding protein HTF4; E-box-binding protein; Transcription factor HTF-4128267471312219144607514702039154893341657217116616331169642431746795317525332179740051822033618669648188677919204326196903322006823121406692233544362427556925271085HTF4TCF12TCF12TCF12TCF12TCF12TCF12TCF12TCF12TCF12TCF12TCF12TCF12TCF12TCF12TCF12TCF12TCF12TCF12TCF12TCF12TCF12TCF12TCF12TCF12Transcription factor 12 TCF-12 Class B basic helix-loop-helix protein 20 bHLHb20 DNA-binding protein HTF4 E-box-binding protein Transcription factor HTF-4211IGFBP6C - Cellular Fate and OrganizationGolgi apparatusIEAextracellular regionTASextracellular spaceIBAextracellular exosomeIDAsignal transductionNASnegative regulation of cell proliferationTASregulation of insulin-like growth factor receptor signaling pathwayIBAregulation of cell growthIEAcellular protein metabolic processTASinsulin-like growth factor I bindingIBAinsulin-like growth factor II bindingIBAInsulin-like growth factor-binding protein 6; IBP-6; IGF-binding protein 6; IGFBP-6; Precursor100872961032965015489334169758317091611719383185025719838169215449525517329572875IBP6IGFBP6IGFBP6IGFBP6IGFBP6IGFBP6IGFBP6IGFBP6IGFBP6IGFBP6IGFBP6IGFBP6IGFBP6IGFBP6IGFBP6IGFBP6IGFBP6IGFBP6IGFBP6IGFBP6IGFBP6IGFBP6IGFBP6IGFBP6IGFBP6IGFBP6IGFBP6Insulin-like growth factor-binding protein 6 IBP-6 IGF-binding protein 6 IGFBP-6 Precursor452ATXN1C - Cellular Fate and OrganizationcytoplasmIDAnucleoplasmIDAnucleusIDAnuclear matrixIDAnuclear inclusion bodyIDAintracellular membrane-bounded organelleIDAadult locomotory behaviorIEARNA processingNASlung alveolus developmentIEAexcitatory postsynaptic potentialIEAnegative regulation of transcription from RNA polymerase II promoterIEAtranscription, DNA-templatedIEAnegative regulation of phosphorylationIEAnegative regulation of insulin-like growth factor receptor signaling pathwayIEApositive regulation of transcription from RNA polymerase II promoterIEAvisual learningIEAnuclear exportIDAnegative regulation of transcription, DNA-templatedIDApoly(U) RNA bindingIDApoly(G) bindingIDAchromatin bindingIEAprotein self-associationIDAprotein C-terminus bindingIPIDNA bindingIEAidentical protein bindingIPIAtaxin-1; Spinocerebellar ataxia type 1 protein110019341113671012062018120931611274198614574404145836071548933415824120161211961671356918669648214752497951322863472090979539353121ATX1ATXN1ATXN1ATXN1ATXN1ATXN1ATXN1ATXN1ATXN1ATXN1ATXN1ATXN1ATXN1ATXN1ATXN1ATXN1ATXN1ATXN1ATXN1ATXN1ATXN1ATXN1ATXN1ATXN1ATXN1ATXN1ATXN1ATXN1ATXN1ATXN1ATXN1ATXN1ATXN1ATXN1ATXN1Ataxin-1 Spinocerebellar ataxia type 1 protein204GDF11C - Cellular Fate and Organizationprotein complexIPIextracellular spaceIBAmetanephros developmentIEAureteric bud developmentIEAspinal cord anterior/posterior patterningIEAnegative regulation of cell proliferationIEApositive regulation of pathway-restricted SMAD protein phosphorylationIBAregulation of apoptotic processIBAcamera-type eye morphogenesisIEASMAD protein signal transductionIBAnervous system developmentTASskeletal system developmentTASpancreas developmentIEAregulation of MAPK cascadeIBApalate developmentIEAcell maturationIEAmesoderm developmentTAScell developmentIBAnegative regulation of cell differentiationIEAgrowthIEAtransforming growth factor beta receptor bindingIBAcytokine activityIBAGrowth/differentiation factor 11; GDF-11; Bone morphogenetic protein 11; BMP-11; Precursor1007585410391213GDF11GDF11GDF11GDF11GDF11GDF11GDF11GDF11GDF11GDF11GDF11GDF11GDF11GDF11GDF11GDF11GDF11GDF11GDF11GDF11GDF11GDF11GDF11GDF11GDF11GDF11GDF11GDF11GDF11Growth/differentiation factor 11 GDF-11 Bone morphogenetic protein 11 BMP-11 Precursor787C - Cellular Fate and OrganizationcytoplasmIDAcell surfaceIDAsynapseIEAapical part of cellIEAextracellular regionTASsecretory granuleIEAextracellular spaceIEAextracellular exosomeIDAresponse to hypoxiaIEAsynaptic transmission, glutamatergicIEAsmooth muscle cell migrationIEAresponse to peptide hormoneIEAtransmembrane transportTASresponse to cAMPIEAnegative regulation of proteolysisIDAblood coagulationTASregulation of synaptic plasticityIEAproteolysisTASplasminogen activationIDAplatelet-derived growth factor receptor signaling pathwayIEAfibrinolysisTAScellular protein modification processTAScellular response to dexamethasone stimulusIEApositive regulation of ovulationIEAserine-type endopeptidase activityIDATissue-type plasminogen activator; t-PA; t-plasminogen activator; tPA; 3.4.21.68; Alteplase; Reteplase; Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B; Precursor103409971138497813100331368681147020391475925815489334160248416453361762144190043119017892107528251318625587182824147300948230904013133640316189360891986337343643397665728976682760758289986139829305622TPAPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATPLATTissue-type plasminogen activator t-PA t-plasminogen activator tPA 3.4.21.68 Alteplase Reteplase Tissue-type plasminogen activator chain A Tissue-type plasminogen activator chain B Precursor365STMN2C - Cellular Fate and Organizationneuron projectionIDAaxonIEAcytoplasmIDAperinuclear region of cytoplasmIDAGolgi apparatusIEAmembraneIEAneuronal cell bodyIDAvesicleIEAlamellipodiumIDAendosomeIEAgrowth coneIDAnegative regulation of microtubule polymerizationIDApositive regulation of microtubule depolymerizationIDAcellular response to nerve growth factor stimulusIDApositive regulation of neuron projection developmentIDAnegative regulation of microtubule depolymerizationIDAnegative regulation of neuron projection developmentIDAtubulin bindingIBAcalcium-dependent protein bindingIPIStathmin-2; Superior cervical ganglion-10 protein; Protein SCG101470203915489334155617181642157118452648206219752121577721471001242755698622778STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2STMN2Stathmin-2 Superior cervical ganglion-10 protein Protein SCG10172C - Cellular Fate and Organizationmediator complexIDAnucleoplasmTASnucleusIDAgene expressionTAStranscription initiation from RNA polymerase II promoterTASNotch signaling pathwayTASpositive regulation of transcription from RNA polymerase II promoterTAStransforming growth factor beta receptor signaling pathwayTAStranscription, DNA-templatedTASprotein kinase activityTASRNA polymerase II carboxy-terminal domain kinase activityIEAATP bindingIEAcyclin-dependent protein serine/threonine kinase activityIEACyclin-dependent kinase 8; 2.7.11.22; 2.7.11.23; Cell division protein kinase 8; Mediator complex subunit CDK8; Mediator of RNA polymerase II transcription subunit CDK8; Protein kinase K35100248831099308215057823151751631548933415546612159899671700077917344846193691952180699675680349734358CDK8CDK8CDK8CDK8CDK8CDK8CDK8CDK8CDK8CDK8CDK8CDK8CDK8CDK8CDK8CDK8CDK8CDK8CDK8CDK8CDK8CDK8CDK8CDK8CDK8CDK8CDK8CDK8CDK8Cyclin-dependent kinase 8 2.7.11.22 2.7.11.23 Cell division protein kinase 8 Mediator complex subunit CDK8 Mediator of RNA polymerase II transcription subunit CDK8 Protein kinase K35177FAM174AN - Not Matchedintegral component of membraneIEAMembrane protein FAM174A; Hepatitis C virus NS5A-transactivated protein 6; HCV NS5A-transactivated protein 6; Transmembrane protein 157; Precursor12975309147020391537202215489334F174AFAM174AFAM174AFAM174AFAM174AFAM174AFAM174AFAM174AFAM174AFAM174AFAM174AFAM174AFAM174AFAM174AFAM174AFAM174AFAM174AFAM174AFAM174AFAM174AFAM174AFAM174AFAM174AMembrane protein FAM174A Hepatitis C virus NS5A-transactivated protein 6 HCV NS5A-transactivated protein 6 Transmembrane protein 157 Precursor165CGREF1D - Genome Maintenanceextracellular regionIEAnegative regulation of cell growthIEAnegative regulation of cell proliferationTASresponse to stressTAScell cycle arrestIEAcell adhesionIEAcalcium ion bindingIEACell growth regulator with EF hand domain protein 1; Cell growth regulatory gene 11 protein; Hydrophobestin; Precursor1470203915489334158156218968090CGRE1CGREF1CGREF1CGREF1CGREF1CGREF1CGREF1Cell growth regulator with EF hand domain protein 1 Cell growth regulatory gene 11 protein Hydrophobestin Precursor370LAMA3C - Cellular Fate and Organizationlaminin-5 complexIEAlaminin-1 complexIEAextracellular regionTASbasement membraneTASextracellular exosomeIDAregulation of cell migrationIEAregulation of embryonic developmentIEAepidermis developmentTASextracellular matrix disassemblyTASextracellular matrix organizationTAScell junction assemblyTAShemidesmosome assemblyTAScell adhesionIEAendodermal cell differentiationIEPregulation of cell adhesionIEAstructural molecule activityNASLaminin subunit alpha-3; Epiligrin 170 kDa subunit; E170; Epiligrin subunit alpha; Kalinin subunit alpha; Laminin-5 subunit alpha; Laminin-6 subunit alpha; Laminin-7 subunit alpha; Nicein subunit alpha; Precursor1291547715044476161777912126946080772308586427LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3LAMA3Laminin subunit alpha-3 Epiligrin 170 kDa subunit E170 Epiligrin subunit alpha Kalinin subunit alpha Laminin-5 subunit alpha Laminin-6 subunit alpha Laminin-7 subunit alpha Nicein subunit alpha Precursor347TCF3D - Genome Maintenanceprotein complexIDAtranscription factor complexIDAcytoplasmIDAnuclear chromatinIDARNA polymerase II transcription factor complexIDAnucleoplasmIDAnucleusIDAnuclear nucleosomeIEApositive regulation of B cell proliferationIMPregulation of G1/S transition of mitotic cell cycleIDAmuscle cell differentiationTASpositive regulation of sequence-specific DNA binding transcription factor activityIDAPeyer's patch developmentIEApositive regulation of transcription from RNA polymerase II promoterIDAB cell differentiationNASresponse to lipopolysaccharideIEAnatural killer cell differentiationIEAcell developmentIEAB cell lineage commitmentIDAregulation of transcription, DNA-templatedNAST cell differentiation in thymusIEAimmunoglobulin V(D)J recombinationIDAresponse to drugIEAprotein stabilizationIEAnegative regulation of transcription from RNA polymerase II promoterIDApositive regulation of cell cycleIDAtranscription, DNA-templatedIDApositive regulation of muscle cell differentiationTAShistone H3 acetylationIEApositive regulation of neuron differentiationISShistone H4 acetylationIEApositive regulation of transcription, DNA-templatedIDAtranscription factor activity, sequence-specific DNA bindingIDAprotein heterodimerization activityIDAtranscription coactivator activityIDAbHLH transcription factor bindingIPIE-box bindingIDAmitogen-activated protein kinase kinase kinase bindingIPIRNA polymerase II core promoter proximal region sequence-specific DNA bindingIDADNA bindingIDAenhancer bindingICprotein homodimerization activityIDAtranscriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific bindingIDAchromatin bindingIEArepressing transcription factor bindingIPIvitamin D response element bindingIDAtranscription factor bindingIPITranscription factor E2-alpha; Class B basic helix-loop-helix protein 21; bHLHb21; Immunoglobulin enhancer-binding factor E12/E47; Immunoglobulin transcription factor 1; Kappa-E2-binding factor; Transcription factor 3; TCF-3; Transcription factor ITF-110086727138616214752053150446081505782415489334167156016959974169642431746795318187571866964819679821967983196903322006823121055282112746214066922308859249399084339709409784TFE2TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3TCF3Transcription factor E2-alpha Class B basic helix-loop-helix protein 21 bHLHb21 Immunoglobulin enhancer-binding factor E12/E47 Immunoglobulin transcription factor 1 Kappa-E2-binding factor Transcription factor 3 TCF-3 Transcription factor ITF-1280C - Cellular Fate and Organizationextracellular matrixIDAendoplasmic reticulum lumenTASextracellular regionTASextracellular spaceIDAextracellular exosomeIDAcollagen type I trimerIDAblood vessel developmentIMPplatelet activationTASRho protein signal transductionIDAleukocyte migrationTASreceptor-mediated endocytosisTASprotein heterotrimerizationIEAskeletal system developmentIMPextracellular matrix disassemblyTAScellular response to amino acid stimulusIEAblood coagulationTASextracellular matrix organizationTAScollagen fibril organizationIMPcollagen catabolic processTASodontogenesisNASregulation of blood pressureIMPtransforming growth factor beta receptor signaling pathwayIDAskin morphogenesisIMPplatelet-derived growth factor bindingIDAprotein binding, bridgingIMPmetal ion bindingIEAidentical protein bindingIDAextracellular matrix structural constituentNASCollagen alpha-2(I) chain; Alpha-2 type I collagen; Precursor104087811062713710987300128447513394531385413150772011548933415777451642148167056911678650916816023168791951827232518747191895312189969191990009201005820526222064612213445392290591223641072365664623947582427556927777642824475283983928973632914942340353634219133680255401142944125295529814609235362675976309769632160266876917520724769371277207407749416786007078814207891382790659179596838081394809407681820808401517844446884568078456808872368188009278829649901653291012909443882CO1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2COL1A2Collagen alpha-2(I) chain Alpha-2 type I collagen Precursor538TCF4T - Transcriptiontranscription factor complexISSnucleusIDADNA-templated transcription, initiationISStranscription initiation from RNA polymerase II promoterISSpositive regulation of neuron differentiationISSpositive regulation of transcription from RNA polymerase II promoterISSpositive regulation of transcription, DNA-templatedIDAprotein-DNA complex assemblyISStranscription factor activity, TFIIB-class bindingISStranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingISStranscription factor activity, sequence-specific DNA bindingIDAprotein heterodimerization activityISSTFIIB-class transcription factor bindingISSE-box bindingISSprotein C-terminus bindingIPIRNA polymerase II core promoter proximal region sequence-specific DNA bindingISSDNA bindingIDAtranscription factor activity, sequence-specific DNA binding, RNA polymerase recruitingISSTranscription factor 4; TCF-4; Class B basic helix-loop-helix protein 19; bHLHb19; Immunoglobulin transcription factor 2; ITF-2; SL3-3 enhancer factor 2; SEF-214702039154893341617779116811161743625417436255174679531872807119235238201846192105528214066922178922522045651227776752308860240947479302263ITF2TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4TCF4Transcription factor 4 TCF-4 Class B basic helix-loop-helix protein 19 bHLHb19 Immunoglobulin transcription factor 2 ITF-2 SL3-3 enhancer factor 2 SEF-2179MYLIPF - Protein FateintracellularIDAcytoplasmIEAplasma membraneIEAcytoskeletonIEAextrinsic component of membraneIEAprotein destabilizationIEAcholesterol homeostasisIEApositive regulation of protein catabolic processIEAprotein ubiquitinationIDAprotein ubiquitination involved in ubiquitin-dependent protein catabolic processIEAregulation of low-density lipoprotein particle receptor catabolic processIEAmovement of cell or subcellular componentIMPnegative regulation of low-density lipoprotein particle clearanceIEAnervous system developmentIMPcytoskeletal protein bindingIDAubiquitin-protein transferase activityIDAligase activityIEAzinc ion bindingIEAubiquitin protein ligase activityIDAE3 ubiquitin-protein ligase MYLIP; 6.3.2.-; Inducible degrader of the LDL-receptor; Idol; Myosin regulatory light chain interacting protein; MIR1059391811042152128266591455057214574404154893341549887419520913204272812168536222109552MYLIPMYLIPMYLIPMYLIPMYLIPMYLIPMYLIPMYLIPMYLIPMYLIPMYLIPMYLIPMYLIPMYLIPMYLIPMYLIPMYLIPMYLIPMYLIPMYLIPMYLIPMYLIPMYLIPMYLIPMYLIPE3 ubiquitin-protein ligase MYLIP 6.3.2.- Inducible degrader of the LDL-receptor Idol Myosin regulatory light chain interacting protein MIR359ARHGAP26C - Cellular Fate and OrganizationcytoskeletonIEAfocal adhesionIEAcytosolTASplasma membrane organizationIEAregulation of small GTPase mediated signal transductionTASactin cytoskeleton organizationNASsmall GTPase mediated signal transductionTASnervous system developmentNASphospholipid bindingIDARho GTPase-activating protein 26; GTPase regulator associated with focal adhesion kinase; Oligophrenin-1-like protein; Rho-type GTPase-activating protein 261090864815489334242755699734811RHG26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26ARHGAP26Rho GTPase-activating protein 26 GTPase regulator associated with focal adhesion kinase Oligophrenin-1-like protein Rho-type GTPase-activating protein 26227C - Cellular Fate and OrganizationcytoplasmIDAmembraneNASGolgi membraneTASendolysosome membraneTASintegral component of plasma membraneTASendoplasmic reticulum membraneTASlysosomal membraneIDAendosome membraneTASpositive regulation of interleukin-6 productionIDApositive regulation of NF-kappaB import into nucleusIDAtoll-like receptor 4 signaling pathwayTASpositive regulation of toll-like receptor signaling pathwayIDAcellular response to interferon-betaIEAnecroptotic signaling pathwayIDApositive regulation of JNK cascadeIEAI-kappaB kinase/NF-kappaB signalingTASpositive regulation of interleukin-12 productionISSpositive regulation of interleukin-8 productionIDAMyD88-independent toll-like receptor signaling pathwayTASdefense response to virusTASpositive regulation of NF-kappaB transcription factor activityIEAinflammatory responseIEApositive regulation of transcription from RNA polymerase II promoterISSpositive regulation of interferon-gamma biosynthetic processIDAdetection of virusNASmicroglial cell activation involved in immune responseIEAtoll-like receptor 3 signaling pathwayTASdefense response to bacteriumTASpositive regulation of interferon-beta productionISSpositive regulation of apoptotic processIEAactivation of NF-kappaB-inducing kinase activityNASpositive regulation of tumor necrosis factor productionISSI-kappaB phosphorylationIDApositive regulation of type III interferon productionIEAnegative regulation of osteoclast differentiationNASpositive regulation of chemokine productionIDAextrinsic apoptotic signaling pathwayIDAhyperosmotic responseNAStoll-like receptor signaling pathwayTAScellular response to drugIEAcellular response to exogenous dsRNAIEAsignal transductionTASpositive regulation of interferon-beta biosynthetic processIDAcellular response to interferon-gammaIEAinnate immune responseTASpositive regulation of inflammatory responseICpositive regulation of interferon-alpha biosynthetic processIDATRIF-dependent toll-like receptor signaling pathwayTAScellular response to mechanical stimulusIEPresponse to exogenous dsRNAIDAmale gonad developmentIEApositive regulation of chemokine biosynthetic processIEAdouble-stranded RNA bindingIDAreceptor activityTASidentical protein bindingIPItransmembrane signaling receptor activityNASToll-like receptor 3; CD283; Precursor1247109512539043147020391534016115489334158156211596163116043704161448341672069916858407170857781717872317872438181721971875364018810425191592182217445322579623226111949435236TLR3TLR3TLR3TLR3TLR3TLR3TLR3TLR3TLR3TLR3TLR3TLR3TLR3TLR3TLR3TLR3TLR3TLR3TLR3TLR3TLR3TLR3TLR3TLR3TLR3TLR3TLR3Toll-like receptor 3 CD283 Precursor595C - Cellular Fate and Organizationcell surfaceIDAplasma membraneTASextracellular regionTASfocal adhesionIDAextracellular spaceIDAextracellular exosomeIDAresponse to hypoxiaIEAregulation of cell adhesion mediated by integrinIDAregulation of receptor activityIDAregulation of smooth muscle cell migrationIDAsmooth muscle cell migrationIEAregulation of smooth muscle cell-matrix adhesionIDAsignal transductionTASregulation of wound healingICchemotaxisTASblood coagulationTASregulation of cell proliferationIEAproteolysisTASfibrinolysisTASserine-type endopeptidase activityTASUrokinase-type plasminogen activator; U-plasminogen activator; uPA; 3.4.21.73; Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B; 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-type plasminogen activator U-plasminogen activator uPA 3.4.21.73 Urokinase-type plasminogen activator long chain A Urokinase-type plasminogen activator short chain A Urokinase-type plasminogen activator chain B Precursor456C - Cellular Fate and Organizationcell surfaceIDAplasma membraneTASblood microparticleIDAplatelet alpha granule lumenTASextracellular regionTASextrinsic component of external side of plasma membraneIDAextracellular spaceIDAextracellular exosomeIDAtissue remodelingIEAnegative regulation of cell proliferationTAStrophoblast giant cell differentiationIEApositive regulation of fibrinolysisIDAnegative regulation of cell-substrate adhesionIDAnegative regulation of fibrinolysisIDAplatelet activationTASnegative regulation of cell-cell adhesion mediated by cadherinTASmononuclear cell migrationIEAtissue regenerationIEAtransmembrane transportTASmuscle cell cellular homeostasisIEAextracellular matrix disassemblyIDAblood coagulationIMPextracellular matrix organizationTASproteolysis involved in cellular protein catabolic processIEAplatelet degranulationTASlabyrinthine layer blood vessel developmentIEAmyoblast differentiationIEAfibrinolysisTAScellular protein metabolic processTASserine-type endopeptidase activityIDAprotein domain specific bindingIPIreceptor bindingIPIserine-type peptidase activityTASapolipoprotein bindingIPIPlasminogen; 3.4.21.7; Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B; Precursor1007759310233898106567991088919211350170120547981229321245687412686314200914277901457440414699093152115111529995115489334160434881657148165714918780401197120471986355214318821578502318848233359902427556930308133356193424011746947296094526614896162164756238949691953975250778054447818147581814768392398861156086525779054441910222191024019201958924252493059499521645954873397837539858247PLMNPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPLGPlasminogen 3.4.21.7 Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B Precursor214C - Cellular Fate and Organizationplasma membraneTASintegral component of membraneIEAsingle organismal cell-cell adhesionNAScell junction assemblyTAShomophilic cell adhesion via plasma membrane adhesion moleculesIEAcell-cell junction organizationTASadherens junction organizationTAScalcium ion bindingIEACadherin-10; T2-cadherin; Precursor1038661610861224169599741866964820068231CAD10CDH10CDH10CDH10CDH10CDH10CDH10CDH10CDH10CDH10CDH10CDH10CDH10CDH10CDH10CDH10CDH10CDH10CDH10CDH10CDH10CDH10CDH10CDH10CDH10CDH10CDH10CDH10CDH10CDH10CDH10CDH10CDH10CDH10CDH10Cadherin-10 T2-cadherin Precursor221C - Cellular Fate and Organizationplasma membraneTASGolgi lumenTASendoplasmic reticulum lumenTASextracellular regionNASintrinsic component of external side of plasma membraneICpositive regulation of protein kinase B signalingIDApeptidyl-glutamic acid carboxylationTASpositive regulation of cell migrationTASblood coagulationICblood coagulation, intrinsic pathwayTASblood coagulation, extrinsic pathwayTASproteolysisTAScellular protein metabolic processTASpost-translational protein modificationTASphospholipid bindingIDAserine-type endopeptidase activityIDAcalcium ion bindingIEACoagulation factor X; 3.4.21.6; Stuart factor; Stuart-Prower factor; Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain; Precursor10391209104688771073937910746568112482821172852712945883154893341565054017227710173930151902434191357061973167198569820427285221713202582420261291827901813011603376833663233926587384687116776696717860069824346183552798529633884546389104909618463FA10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10F10Coagulation factor X 3.4.21.6 Stuart factor Stuart-Prower factor Factor X light chain Factor X heavy chain Activated factor Xa heavy chain Precursor241TNFD - Genome Maintenanceplasma membraneTAScell surfaceIDAintegral component of plasma membraneIDAphagocytic cupISSextracellular regionTASmembrane raftIDArecycling endosomeISSextracellular spaceIDAexternal side of plasma membraneISSpositive regulation of interleukin-6 productionIEApositive regulation of mononuclear cell migrationNASresponse to salt stressTASdefense response to Gram-positive bacteriumIEApositive regulation of cytokine productionIDAnegative regulation of myoblast differentiationIEApositive regulation of fever generationISSpositive regulation of programmed cell deathIDAMAPK cascadeIMPnegative regulation of glucose importIEApositive regulation of protein localization to cell surfaceIDApositive regulation of action potentialIEAnegative regulation of growth of symbiont in hostIEAnegative regulation of viral genome replicationIDAprotein import into nucleus, translocationIDApositive regulation of mitotic nuclear divisionIEAcellular response to nicotineIDApositive regulation of cysteine-type endopeptidase activity involved in apoptotic processIDApositive regulation of chemokine biosynthetic processIDAnegative regulation of lipid catabolic processIDAnecroptotic signaling pathwayIDApositive regulation of cytokine secretionIDAnegative regulation of alkaline phosphatase activityIEAactivation of MAPK activityIDApositive regulation of sequence-specific DNA binding transcription factor activityIDApositive regulation of peptidyl-serine phosphorylationIDApositive regulation of NF-kappaB transcription factor activityIDAinflammatory responseIDAactivation of MAPKKK activityIDAepithelial cell proliferation involved in salivary gland morphogenesisIEAhumoral immune responseIEAglucose metabolic processIEAcell activationIEAresponse to radiationIEApositive regulation of interleukin-18 productionIEAresponse to gold nanoparticleIEAresponse to drugIEApositive regulation of NFAT protein import into nucleusIDApositive regulation of osteoclast differentiationIDAembryonic digestive tract developmentIEPresponse to virusIDApositive regulation of smooth muscle cell proliferationIDApositive regulation of protein transportIDAnegative regulation of lipid storageNASpositive regulation of chemokine (C-X-C motif) ligand 2 productionIDAregulation of immunoglobulin secretionIEApositive regulation of translational initiation by ironIEAnegative regulation of osteoblast differentiationIEAregulation of insulin secretionIDAreceptor biosynthetic processIDAcalcium-mediated signalingIEAnegative regulation of fat cell differentiationNASnegative regulation of interleukin-6 productionIDAleukocyte tethering or rollingIDApositive regulation of neuron apoptotic processIEAsequestering of triglycerideIDAextracellular matrix organizationIEAnegative regulation of branching involved in lung morphogenesisIDApositive regulation of heterotypic cell-cell adhesionIDApositive regulation of ERK1 and ERK2 cascadeNASpositive regulation of I-kappaB kinase/NF-kappaB signalingIDAregulation of I-kappaB kinase/NF-kappaB signalingIDAlipopolysaccharide-mediated signaling pathwayIDApositive regulation of interferon-gamma productionIEApositive regulation of chronic inflammatory response to antigenic stimulusIEApositive regulation of interleukin-8 biosynthetic processIDAresponse to glucocorticoidIDAnegative regulation of transcription from RNA polymerase II promoterIDApositive regulation of chemokine productionIDAnegative regulation of protein complex disassemblyIDAtumor necrosis factor-mediated signaling pathwayIMPpositive regulation of hair follicle developmentIEApositive regulation of synaptic transmissionIEAprotein kinase B signalingIMPpositive regulation of transcription, DNA-templatedIDAnegative regulation of transcription, DNA-templatedIDAextrinsic apoptotic signaling pathway via death domain receptorsIDApositive regulation of protein kinase B signalingIEApositive regulation of NF-kappaB import into nucleusIDApositive regulation of calcidiol 1-monooxygenase activityIDApositive regulation of podosome assemblyIDApositive regulation of membrane protein ectodomain proteolysisIDAchronic inflammatory response to antigenic stimulusIMPnegative regulation of cell proliferationIEAregulation of branching involved in salivary gland morphogenesisIEApositive regulation of vitamin D biosynthetic processIDAtransformed cell apoptotic processIDApositive regulation of nitric oxide biosynthetic processIDAnegative regulation of cytokine secretion involved in immune responseIDApositive regulation of phagocytosisIMPpositive regulation of humoral immune response mediated by circulating immunoglobulinIEAnegative regulation of L-glutamate transportIEApositive regulation of protein complex assemblyIDAcellular response to amino acid stimulusIEApositive regulation of MAP kinase activityIDApositive regulation of protein complex disassemblyIDApositive regulation of transcription from RNA polymerase II promoterIDAnegative regulation of extrinsic apoptotic signaling pathway in absence of ligandIDAdetection of mechanical stimulus involved in sensory perception of painIEApositive regulation of JUN kinase activityIDAresponse to hypoxiaIEAresponse to activityIEApositive regulation of apoptotic processIDAintrinsic apoptotic signaling pathway in response to DNA damageIEAactivation of cysteine-type endopeptidase activity involved in apoptotic processIDAJNK cascadeIEAosteoclast differentiationIEAextrinsic apoptotic signaling pathwayIDAapoptotic signaling pathwayTASpositive regulation of gene expressionIDAcellular response to organic cyclic compoundIDAskeletal muscle contractionIEAnegative regulation of gene expressionIDApositive regulation of protein phosphorylationIDAtumor necrosis factor receptor bindingIDAtranscription regulatory region DNA bindingIDAprotease bindingIPIcytokine activityIDAidentical protein bindingIDATumor necrosis factor; Cachectin; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Tumor necrosis factor, membrane form; N-terminal fragment; NTF; Intracellular domain 1; ICD1; Intracellular domain 2; ICD2; C-domain 1; C-domain 2; Tumor necrosis factor, soluble form; Precursor10202016102051661036925512746914129154571402651146569671548933416829951168299521964681200986025519052922050299592735559743856324388319539320696392892849994785978708631363903419194420569488135TNFATNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTNFTumor necrosis factor Cachectin TNF-alpha Tumor necrosis factor ligand superfamily member 2 TNF-a Tumor necrosis factor, membrane form N-terminal fragment NTF Intracellular domain 1 ICD1 Intracellular domain 2 ICD2 C-domain 1 C-domain 2 Tumor necrosis factor, soluble form Precursor217SPOCK2C - Cellular Fate and Organizationproteinaceous extracellular matrixNASsignal transductionIEApeptide cross-linking via chondroitin 4-sulfate glycosaminoglycanIEAextracellular matrix organizationNASpositive regulation of cell-substrate adhesionIEAregulation of cell differentiationNASsynapse assemblyNAScalcium ion bindingIDAextracellular matrix bindingIEAglycosaminoglycan bindingIEATestican-2; SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2; Precursor1038695012975309147020391516405415340161154893349039502TICN2SPOCK2SPOCK2SPOCK2SPOCK2SPOCK2SPOCK2SPOCK2SPOCK2SPOCK2SPOCK2SPOCK2SPOCK2SPOCK2SPOCK2SPOCK2SPOCK2SPOCK2SPOCK2SPOCK2SPOCK2SPOCK2SPOCK2SPOCK2SPOCK2SPOCK2SPOCK2SPOCK2SPOCK2SPOCK2SPOCK2SPOCK2SPOCK2SPOCK2SPOCK2Testican-2 SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2 Precursor407D - Genome Maintenanceinhibin A complexIDAextracellular regionIDAactivin A complexIDAnegative regulation of B cell differentiationTAShemoglobin biosynthetic processIDAnegative regulation of cell growthIDAnegative regulation of cell proliferationIDAprogesterone secretionIGIcell-cell signalingTASendodermal cell differentiationIDASMAD protein signal transductionIBAcell differentiationTAScellular response to follicle-stimulating hormone stimulusIEAovarian follicle developmentIGIG1/S transition of mitotic cell cycleIDAcellular response to cholesterolIEAnegative regulation of interferon-gamma biosynthetic processTAShematopoietic progenitor cell differentiationIDAeyelid development in camera-type eyeISSpositive regulation of transcription from RNA polymerase II promoterIDAregulation of MAPK cascadeIBAodontogenesisIGIpalate developmentIGIcell cycle arrestIDApositive regulation of extrinsic apoptotic signaling pathway in absence of ligandIDAcell developmentIBAmesodermal cell differentiationIEAhair follicle developmentIGIregulation of transcription from RNA polymerase II promoterIDAresponse to drugIDApositive regulation of pathway-restricted SMAD protein phosphorylationIDAnegative regulation of follicle-stimulating hormone secretionNASdefense responseTASpositive regulation of follicle-stimulating hormone secretionTASregulation of follicle-stimulating hormone secretionIGIextrinsic apoptotic signaling pathwayIDAnegative regulation of cell cycleIDAactivin receptor signaling pathwayIDAnegative regulation of macrophage differentiationTASnervous system developmentNASnegative regulation of phosphorylationTASpositive regulation of cellular protein metabolic processIDApositive regulation of erythrocyte differentiationIDAerythrocyte differentiationNASpositive regulation of transcription, DNA-templatedIDAgrowthIEAmale gonad developmentIGIcell surface receptor signaling pathwayTASpositive regulation of ovulationISStype II activin receptor bindingIPIhormone activityTASpeptide hormone bindingIPIgrowth factor activityTAStransforming growth factor beta receptor bindingIBAcytokine activityIDAidentical protein bindingIPIInhibin beta A chain; Activin beta-A chain; Erythroid differentiation protein; EDF; Precursor12660162126976701285394815489334177767318768470326720937544423758355INHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAINHBAInhibin beta A chain Activin beta-A chain Erythroid differentiation protein EDF Precursor297N - Not Matchedcell surfaceISSintegral component of membraneIEAextracellular exosomeIDAestablishment of glial blood-brain barrierISSMatrix-remodeling-associated protein 8; Limitrin; Precursor14603461147020391548933416710414MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8MXRA8Matrix-remodeling-associated protein 8 Limitrin Precursor265N - Not Matchedcollagen trimerTASproteinaceous extracellular matrixIEAendoplasmic reticulum lumenTASextracellular regionTAScell cortexIEAskeletal system developmentTASendochondral ossificationIEAextracellular matrix disassemblyTASextracellular matrix organizationTAScartilage developmentIEAcollagen catabolic processTASmetal ion bindingIEACollagen alpha-1(X) chain; Precursor1183930213973331457440415489334158727115880705174340117640252037056760765578762258004099830433687820439067753910129098378189852679COAA1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1COL10A1Collagen alpha-1(X) chain Precursor226PHYHIPPhytanoyl-CoA hydroxylase-interacting protein; Phytanoyl-CoA hydroxylase-associated protein 1; PAHX-AP1; PAHXAP110686344154893349039502PHYIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPHYHIPPhytanoyl-CoA hydroxylase-interacting protein Phytanoyl-CoA hydroxylase-associated protein 1 PAHX-AP1 PAHXAP1176SH2B1D - Genome MaintenancemembraneIEAnucleusIEAcytosolTASintracellular signal transductionIEAblood coagulationTASlamellipodium assemblyIEApositive regulation of mitotic nuclear divisionIEAregulation of DNA biosynthetic processIEAsignal transducer activityIEASH2B adapter protein 1; Pro-rich, PH and SH2 domain-containing signaling mediator; PSM; SH2 domain-containing protein 1B105942401071819811751854118279561456596014702039154893341561655315767667165696691747123617974005182203361866964824275569949855296948829742218SH2B1SH2B1SH2B1SH2B1SH2B1SH2B1SH2B1SH2B1SH2B1SH2B1SH2B1SH2B1SH2B1SH2B1SH2B1SH2B1SH2B1SH2B1SH2B1SH2B1SH2B1SH2B1SH2B1SH2B1SH2B1SH2B1SH2B1SH2B1SH2B1SH2B1SH2B1SH2B adapter protein 1 Pro-rich, PH and SH2 domain-containing signaling mediator PSM SH2 domain-containing protein 1B204ATRNA - Transport and SensingcytoplasmIEAplasma membraneNASintegral component of plasma membraneTASextracellular spaceIDAextracellular exosomeIDAinflammatory responseIEAmyelinationIEAregulation of multicellular organism growthIEApigmentationIEAcerebellum developmentIEAresponse to oxidative stressIEAcarbohydrate bindingIEAreceptor activityTASAttractin; DPPT-L; Mahogany homolog; Precursor108119181178005214702039147607181548933416335952172610781913949019159218753979996285819736737ATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNATRNAttractin DPPT-L Mahogany homolog Precursor556PRKCQC - Cellular Fate and Organizationimmunological synapseIEAplasma membraneTAScytosolTASpositive regulation of T-helper 17 type immune responseISST cell receptor signaling pathwayTASpositive regulation of interleukin-4 productionISSprotein ubiquitinationTASphototransduction, visible lightTASnegative regulation of T cell apoptotic processIMPregulation of cell growthNAScellular component disassembly involved in execution phase of apoptosisTASintracellular signal transductionNASinflammatory responseIEApositive regulation of NF-kappaB transcription factor activityIDAaxon guidanceTASpositive regulation of T cell proliferationIEAmembrane protein ectodomain proteolysisISSrhodopsin mediated signaling pathwayTASregulation of transcription, DNA-templatedISSpositive regulation of interleukin-17 productionISSnegative regulation of insulin receptor signaling pathwayIMPregulation of platelet aggregationISSapoptotic processTASplatelet activationTASregulation of rhodopsin mediated signaling pathwayTASpositive regulation of interleukin-2 biosynthetic processIEAblood coagulationTASinnate immune responseTASpositive regulation of T cell activationISSpositive regulation of T-helper 2 cell activationISSFc-epsilon receptor signaling pathwayTASubiquitin-protein transferase activityTASprotein serine/threonine kinase activityNASprotein kinase C activityIEAATP bindingIEAmetal ion bindingIEAProtein kinase C theta type; 2.7.11.13; nPKC-theta10636891106523561134261011772397118616171247318414702039149887271516405415254234152825621536491915364937154893341625200416356855167098301697853417344846175442921832878618691976193691951954998519690332212694602140669221944869242755697686153798307784448778657160KPCTPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQPRKCQProtein kinase C theta type 2.7.11.13 nPKC-theta205PLEKHH1N - Not MatchedcytoskeletonIEAPleckstrin homology domain-containing family H member 1; PH domain-containing family H member 1105744621470203915489334PKHH1PLEKHH1PLEKHH1PLEKHH1PLEKHH1PLEKHH1PLEKHH1PLEKHH1PLEKHH1PLEKHH1PLEKHH1PLEKHH1PLEKHH1PLEKHH1PLEKHH1PLEKHH1PLEKHH1PLEKHH1PLEKHH1PLEKHH1PLEKHH1PLEKHH1PLEKHH1PLEKHH1PLEKHH1PLEKHH1PLEKHH1PLEKHH1PLEKHH1PLEKHH1PLEKHH1PLEKHH1PLEKHH1PLEKHH1PLEKHH1PLEKHH1PLEKHH1Pleckstrin homology domain-containing family H member 1 PH domain-containing family H member 1251TRIM46N - Not MatchedintracellularIEAzinc ion bindingIEATripartite motif-containing protein 46; Gene Y protein; GeneY; Tripartite, fibronectin type-III and C-terminal SPRY motif protein14702039154893341643439316710414TRI46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46TRIM46Tripartite motif-containing protein 46 Gene Y protein GeneY Tripartite, fibronectin type-III and C-terminal SPRY motif protein271RUSC2C - Cellular Fate and Organizationcytoplasmic vesicleIDAcytosolIEAextracellular exosomeIDARab GTPase bindingIPIIporin; Interacting protein of Rab1; RUN and SH3 domain-containing protein 21516405315489334157967811708198318220336186696489205841RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2RUSC2Iporin Interacting protein of Rab1 RUN and SH3 domain-containing protein 2259C - Cellular Fate and Organizationplasma membraneTASGolgi lumenTASendoplasmic reticulum lumenTASextracellular regionTASvesicleIEAextracellular spaceIEApositive regulation of protein kinase B signalingIDAresponse to growth hormoneIEAresponse to estrogenIEApositive regulation of cell migrationTASorgan regenerationIEApositive regulation of leukocyte chemotaxisIDApositive regulation of positive chemotaxisIDApeptidyl-glutamic acid carboxylationTASblood coagulationTASpositive regulation of blood coagulationIEAblood coagulation, extrinsic pathwayTASproteolysisTAScircadian rhythmTASpositive regulation of platelet-derived growth factor receptor signaling pathwayIDAresponse to vitamin KIEAcellular protein metabolic processTASpost-translational protein modificationTASglycoprotein bindingIPIserine-type endopeptidase activityTAScalcium ion bindingIEAserine-type peptidase activityTASCoagulation factor VII; 3.4.21.21; Proconvertin; Serum prothrombin conversion accelerator; SPCA; Eptacog alfa; Factor VII light chain; Factor VII heavy chain; Precursor103912091086207910984565110911941112933212472587147177811505782315489334162926731634227189762471904059191673291943292719751712207004721206266212936721372693219493562511201303753732647253486420786008179743467981691804344382048798242057836454485989038652821884420888832608940045902354694142789452082957618096929509925787FA7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7F7Coagulation factor VII 3.4.21.21 Proconvertin Serum prothrombin conversion accelerator SPCA Eptacog alfa Factor VII light chain Factor VII heavy chain Precursor198LAMB2C - Cellular Fate and Organizationbasal laminaTASsynapseIEAextracellular regionTASlaminin-3 complexIPIlaminin-11 complexTASbasement membraneIDAextracellular exosomeIDAretina development in camera-type eyeIEAmetanephric glomerular visceral epithelial cell developmentIEAaxon guidanceIEAneuromuscular junction developmentIEAastrocyte developmentIEAextracellular matrix organizationTASmetanephric glomerular basement membrane developmentIEASchwann cell developmentIEAcell adhesionIEAaxon extension involved in regenerationIEAvisual perceptionIEAstructural molecule activityNASLaminin subunit beta-2; Laminin B1s chain; Laminin-11 subunit beta; Laminin-14 subunit beta; Laminin-15 subunit beta; Laminin-3 subunit beta; Laminin-4 subunit beta; Laminin-7 subunit beta; Laminin-9 subunit beta; S-laminin subunit beta; S-LAM beta; Precursor15367484169127101915921821236492212694602427556976987457795887LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2LAMB2Laminin subunit beta-2 Laminin B1s chain Laminin-11 subunit beta Laminin-14 subunit beta Laminin-15 subunit beta Laminin-3 subunit beta Laminin-4 subunit beta Laminin-7 subunit beta Laminin-9 subunit beta S-laminin subunit beta S-LAM beta Precursor166MMP16F - Protein Fatecell surfaceIEAplasma membraneTASGolgi lumenTASintegral component of plasma membraneTASproteinaceous extracellular matrixIEAendochondral ossificationIEAextracellular matrix disassemblyTASextracellular matrix organizationTAScollagen catabolic processIEApositive regulation of catalytic activityTAScraniofacial suture morphogenesisIEAembryonic cranial skeleton morphogenesisIEAchondrocyte proliferationIEAcalcium ion bindingIEAzinc ion bindingTASenzyme activator activityTASmetalloendopeptidase activityTASMatrix metalloproteinase-16; MMP-16; 3.4.24.-; MMP-X2; Membrane-type matrix metalloproteinase 3; MT-MMP 3; MTMMP3; Membrane-type-3 matrix metalloproteinase; MT3-MMP; MT3MMP; Precursor11278606147020391474121715489334755944090925079396633MMP16MMP16MMP16MMP16MMP16MMP16MMP16MMP16MMP16MMP16MMP16MMP16MMP16MMP16MMP16MMP16MMP16MMP16MMP16MMP16MMP16MMP16MMP16MMP16MMP16MMP16MMP16Matrix metalloproteinase-16 MMP-16 3.4.24.- MMP-X2 Membrane-type matrix metalloproteinase 3 MT-MMP 3 MTMMP3 Membrane-type-3 matrix metalloproteinase MT3-MMP MT3MMP Precursor167TMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11ETMPRSS11E460D - Genome Maintenancereceptor complexIDAmembraneIDAplasma membraneICintegral component of plasma membraneIDAcaveolaIDAinsulin receptor complexIMPendosome membraneTASextracellular exosomeIDAintracellular membrane-bounded organelleIDAinsulin receptor signaling pathwayIDApositive regulation of protein kinase B signalingIMPpositive regulation of cell proliferationIDAprotein heterotetramerizationIDApositive regulation of respiratory burstIDApositive regulation of nitric oxide biosynthetic processIMPactivation of protein kinase activityIMPactivation of MAPK activityIMPprotein autophosphorylationIMPpositive regulation of glucose importIDAmale sex determinationIEAactivation of protein kinase B activityIDApositive regulation of glycolytic processIMPpeptidyl-tyrosine autophosphorylationIEAsignal transduction by protein phosphorylationIDAtransformation of host cell by virusIMPregulation of transcription, DNA-templatedIMPcellular response to insulin stimulusIDApositive regulation of cell migrationIMPpositive regulation of glycogen biosynthetic processIDAcarbohydrate metabolic processIEApositive regulation of DNA replicationIMPpositive regulation of mitotic nuclear divisionIMPpeptidyl-tyrosine phosphorylationIDAglucose homeostasisIMPregulation of embryonic developmentIMPheart morphogenesisIMPcellular response to growth factor stimulusIEAepidermis developmentIEAG-protein coupled receptor signaling pathwayIDApositive regulation of developmental growthIMPexocrine pancreas developmentIEApositive regulation of protein phosphorylationIDApositive regulation of MAPK cascadeIDAinsulin-activated receptor activityIDAinsulin-like growth factor receptor bindingIDAinsulin-like growth factor I bindingIPIPTB domain bindingIPIinsulin-like growth factor II bindingIPIinsulin receptor substrate bindingIPIGTP bindingIDAATP bindingIDAprotein tyrosine kinase activityIMPinsulin bindingIDAreceptor signaling protein tyrosine kinase activityIDAphosphatidylinositol 3-kinase bindingIPIInsulin receptor; IR; 2.7.10.1; CD220; Insulin receptor subunit alpha; Insulin receptor subunit beta; Precursor1020705310443650106159441073323810734133108034661112496411260230113748981159812011726652120239891210774612138094124937401253862612612081127072681297029513216051469059314701631472036150578241516176615489334156358215738637160706716070761612746016246733162718871631450516493415168318751689414716957736172017971730625173448461734779918278056186696481876716518901611905626319071018191592181934997319369195193942231945960919634732002058203484182040394212173421683972210055221173022807792330286223658192369896242755692479553253812425449972544998256654527777892806055283482428420602859121298322231010643166375328393834471553680248753784975381437559478765703278154427983039799726280827808096518818871582420678243830825768882768098288049831400883264908388389839094984199458432414845253084585338636294889072989952828999839917579091995759202395924986792993959312016935575594286929703342INSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRINSRInsulin receptor IR 2.7.10.1 CD220 Insulin receptor subunit alpha Insulin receptor subunit beta Precursor262CBFA2T3C - Cellular Fate and OrganizationGolgi membraneIEAnucleolusIEAnucleoplasmIEAnucleusIBAcell proliferationTASpositive regulation of transcription from RNA polymerase II promoterIEAgranulocyte differentiationIDAnegative regulation of transcription, DNA-templatedIBAtranscription, DNA-templatedIEAtranscription factor activity, sequence-specific DNA bindingIEAtranscription corepressor activityIBAchromatin bindingIEAmetal ion bindingIEAProtein CBFA2T3; MTG8-related protein 2; Myeloid translocation gene on chromosome 16 protein; hMTG16; Zinc finger MYND domain-containing protein 4109950191122449611533236118234861218341412242670152316651547002015489334156762131681584216959974169664341720397319690332201388772427556995966469790752MTG16CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3CBFA2T3Protein CBFA2T3 MTG8-related protein 2 Myeloid translocation gene on chromosome 16 protein hMTG16 Zinc finger MYND domain-containing protein 4365C - Cellular Fate and Organizationplasma membraneIEAcytosolTASregulation of gene expressionIMPregulation of small GTPase mediated signal transductionTASvascular endothelial growth factor receptor signaling pathwayTASneurotrophin TRK receptor signaling pathwayTASpositive regulation of apoptotic processTASephrin receptor signaling pathwayTASsmall GTPase mediated signal transductionTASlamellipodium assemblyIEAplatelet activationTASangiogenesisIEAapoptotic signaling pathwayTASsignal transductionTASpositive regulation of phosphatidylinositol 3-kinase activityIEAcell migrationIEAregulation of blood coagulationIMPblood coagulationTASaxon guidanceTASinnate immune responseTASFc-gamma receptor signaling pathway involved in phagocytosisTASFc-epsilon receptor signaling pathwayTASguanyl-nucleotide exchange factor activityEXPRho guanyl-nucleotide exchange factor activityIEAmetal ion bindingIEAGuanine nucleotide exchange factor VAV2; VAV-2124540191516405315489334155611061561828616964243179740051866964818691976194133302006823121269460242755697762982VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2VAV2Guanine nucleotide exchange factor VAV2 VAV-2681CELSR2C - Cellular Fate and OrganizationcytoplasmISSplasma membraneISSintegral component of membraneNASregulation of cell-cell adhesionISSregulation of transcription, DNA-templatedISScilium movementIEAneural plate anterior/posterior regionalizationISSregulation of protein localizationIEAdendrite morphogenesisISScilium assemblyIEAG-protein coupled receptor signaling pathwayNASventricular system developmentIEAcerebrospinal fluid secretionIEAWnt signaling pathwayISSneuron migrationIEAhomophilic cell adhesion via plasma membrane adhesion moleculesISSG-protein coupled receptor activityNAScalcium ion bindingIEACadherin EGF LAG seven-pass G-type receptor 2; Cadherin family member 10; Epidermal growth factor-like protein 2; EGF-like protein 2; Flamingo homolog 3; Multiple epidermal growth factor-like domains protein 3; Multiple EGF-like domains protein 3; Precursor1090785616710414186696489039502CELR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2CELSR2Cadherin EGF LAG seven-pass G-type receptor 2 Cadherin family member 10 Epidermal growth factor-like protein 2 EGF-like protein 2 Flamingo homolog 3 Multiple epidermal growth factor-like domains protein 3 Multiple EGF-like domains protein 3 Precursor195LSAMPC - Cellular Fate and Organizationneuron projectionIBAplasma membraneIBAcell surfaceIBAcell-cell junctionIBAneuronal cell bodyIBAanchored component of membraneIEAsingle organismal cell-cell adhesionIBAregulation of neurogenesisIBAnervous system developmentTASlocomotory exploration behaviorIEALimbic system-associated membrane protein; LSAMP; IgLON family member 3; Precursor15489334193499738666243LSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLSAMPLimbic system-associated membrane protein LSAMP IgLON family member 3 Precursor294SPARCC - Cellular Fate and OrganizationcytoplasmIDAcell surfaceIDAendocytic vesicle lumenTASplatelet alpha granuleIDAplatelet alpha granule membraneIDAplatelet alpha granule lumenTASextracellular regionNASextracellular spaceIEAnuclear matrixIDAbasement membraneIEAlung developmentIEAresponse to ethanolIEAresponse to peptide hormoneIEAresponse to L-ascorbic acidIEAresponse to cAMPIEAheart developmentIEAextracellular matrix organizationTASregulation of cell morphogenesisIDAresponse to lipopolysaccharideIEAresponse to cytokineIEAresponse to lead ionIEAinner ear developmentIEAplatelet activationTASresponse to glucocorticoidIEAreceptor-mediated endocytosisTASpositive regulation of endothelial cell migrationIDAbone developmentIEAsignal transductionIEAresponse to calcium ionIEAcellular response to growth factor stimulusIEAresponse to gravityIEAossificationIEAblood coagulationTASnegative regulation of endothelial cell proliferationIDAnegative regulation of angiogenesisIDAplatelet degranulationTASresponse to cadmium ionIEAcollagen bindingIDAcalcium ion bindingIDAextracellular matrix bindingIEASPARC; Basement-membrane protein 40; BM-40; Osteonectin; ON; Secreted protein acidic and rich in cysteine; Precursor1548933417974005230651723380252790009283841234007773410046359743774953008548457923378794579059501084SPRCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARCSPARC Basement-membrane protein 40 BM-40 Osteonectin ON Secreted protein acidic and rich in cysteine Precursor227HTRA1C - Cellular Fate and Organizationextracellular matrixIEAextracellular spaceTASextracellular exosomeIDAcytosolIEApositive regulation of epithelial cell proliferationIEAnegative regulation of BMP signaling pathwayIEAnegative regulation of defense response to virusIEAdentinogenesisIEAproteolysisISSregulation of cell growthIEAnegative regulation of transforming growth factor beta receptor signaling pathwayIEAserine-type endopeptidase activityTASserine-type peptidase activityISSSerine protease HTRA1; 3.4.21.-; High-temperature requirement A serine peptidase 1; L56; Serine protease 11; Precursor1520835516377621170531081705310919387015206710642129763589771049852107HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1HTRA1Serine protease HTRA1 3.4.21.- High-temperature requirement A serine peptidase 1 L56 Serine protease 11 Precursor203KLK7F - Protein Fateepidermal lamellar bodyIDAextracellular regionTASepidermis developmentTASextracellular matrix disassemblyTASextracellular matrix organizationTASserine-type endopeptidase activityIEAserine-type peptidase activityTASKallikrein-7; hK7; 3.4.21.117; Serine protease 6; Stratum corneum chymotryptic enzyme; hSCCE; Precursor10974542110545741187448312738725147020391548933417909180183290422337077777942738034709KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7KLK7Kallikrein-7 hK7 3.4.21.117 Serine protease 6 Stratum corneum chymotryptic enzyme hSCCE Precursor197LAMA1C - Cellular Fate and Organizationextracellular matrixIDAcell-cell junctionIEAproteinaceous extracellular matrixISSlaminin-1 complexIDAextracellular regionTASlaminin-3 complexIPIextracellular spaceIDAbasement membraneIDAregulation of cell migrationIEAmorphogenesis of an epithelial sheetIEAregulation of cell adhesionIEAestablishment of epithelial cell apical/basal polarityIEAregulation of embryonic developmentIEAepithelial tube branching involved in lung morphogenesisIEAretinal blood vessel morphogenesisIEAaxon guidanceTASextracellular matrix organizationTAScell adhesionIEAcell surface receptor signaling pathwayISSbranching involved in salivary gland morphogenesisIEAglycosphingolipid bindingIEAextracellular matrix structural constituentISSLaminin subunit alpha-1; Laminin A chain; Laminin-1 subunit alpha; Laminin-3 subunit alpha; S-laminin subunit alpha; S-LAM alpha; Precursor16177791171453719159218204906725105227251714052733383LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1LAMA1Laminin subunit alpha-1 Laminin A chain Laminin-1 subunit alpha Laminin-3 subunit alpha S-laminin subunit alpha S-LAM alpha Precursor173MED15T - TranscriptioncytoplasmIEAmembraneIDAmediator complexIEAnucleoplasmIDAnucleusIDAgene expressionTAStranscription initiation from RNA polymerase II promoterTASstem cell population maintenanceIEARNA polymerase II transcription cofactor activityIEAMediator of RNA polymerase II transcription subunit 15; Activator-recruited cofactor 105 kDa component; ARC105; CTG repeat protein 7a; Mediator complex subunit 15; Positive cofactor 2 glutamine/Q-rich-associated protein; PC2 glutamine/Q-rich-associated protein; TPA-inducible gene 1 protein; TIG-1; Trinucleotide repeat-containing gene 7 protein10235267110243001141476012167862147020391517516315461802154893341598996716630888167995631690466918568018186696481941333021269460242755699225980MED15MED15MED15MED15MED15MED15MED15MED15MED15MED15MED15MED15MED15MED15MED15MED15MED15MED15MED15MED15MED15MED15MED15MED15MED15MED15MED15Mediator of RNA polymerase II transcription subunit 15 Activator-recruited cofactor 105 kDa component ARC105 CTG repeat protein 7a Mediator complex subunit 15 Positive cofactor 2 glutamine/Q-rich-associated protein PC2 glutamine/Q-rich-associated protein TPA-inducible gene 1 protein TIG-1 Trinucleotide repeat-containing gene 7 protein177SREBF2T - TranscriptionER to Golgi transport vesicle membraneIEAcytoplasmIDAGolgi membraneTASendoplasmic reticulumIDASREBP-SCAP-Insig complexIDAendoplasmic reticulum membraneTASnucleolusIDAnucleoplasmTASnucleusIDAcytosolTASlipid metabolic processTAScellular response to laminar fluid shear stressNASregulation of cholesterol homeostasisIEAsmall molecule metabolic processTASnegative regulation of transcription from RNA polymerase II promoterIDApositive regulation of cholesterol storageIDAresponse to low-density lipoprotein particleIEPpositive regulation of transcription from RNA polymerase II promoterIDAnegative regulation of cholesterol effluxIDAcellular lipid metabolic processTASregulation of lipid transport by negative regulation of transcription from RNA polymerase II promoterIDAcholesterol metabolic processIEAtranscriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific bindingIDAE-box bindingIDAprotein C-terminus bindingIPIRNA polymerase II core promoter proximal region sequence-specific DNA bindingIDASterol regulatory element-binding protein 2; SREBP-2; Class D basic helix-loop-helix protein 2; bHLHd2; Sterol regulatory element-binding transcription factor 2; Processed sterol regulatory element-binding protein 21059120810805775146458511546180215489334169599741970660179034538402897862661086435939651382SRBP2SREBF2SREBF2SREBF2SREBF2SREBF2SREBF2SREBF2SREBF2SREBF2SREBF2SREBF2SREBF2SREBF2SREBF2SREBF2SREBF2SREBF2SREBF2SREBF2SREBF2SREBF2SREBF2SREBF2SREBF2SREBF2SREBF2SREBF2SREBF2SREBF2SREBF2Sterol regulatory element-binding protein 2 SREBP-2 Class D basic helix-loop-helix protein 2 bHLHd2 Sterol regulatory element-binding transcription factor 2 Processed sterol regulatory element-binding protein 2211FBN1N - Not Matchedextracellular matrixIDAproteinaceous extracellular matrixIDAmicrofibrilIDAextracellular regionTASextracellular spaceIDAextracellular exosomeIDAbasement membraneIDAheart developmentIMPmetanephros developmentIEAsequestering of TGFbeta in extracellular matrixISSskeletal system developmentIMPextracellular matrix disassemblyTASsequestering of BMP in extracellular matrixISSextracellular matrix organizationTAScellular response to transforming growth factor beta stimulusIEAcalcium ion bindingIDAextracellular matrix structural constituentIDAFibrillin-1; Precursor1042504110441597106331291069492111700157118260221220398712203992125255391301946146955401506209315161917151658541522163815489334156920616220557162226571657217118522061852207185220818608731915921819446531203750042054708820803651214026942154206021683322219897192427556927390557611299769171977382007762551787007579773668004112804032680719638136837818830282811418364578840649784303178504310856886985945638653794886315988827808988160901652691507269254848933858193385889362480940100394520859837823FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1FBN1Fibrillin-1 Precursor206NCAM2C - Cellular Fate and OrganizationaxonIEAplasma membraneTASintegral component of membraneTASsensory perception of smellIEAaxonal fasciculationIEAneuron cell-cell adhesionTASNeural cell adhesion molecule 2; N-CAM-2; NCAM-2; Precursor108309531275451914702039154893349226371NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2NCAM2Neural cell adhesion molecule 2 N-CAM-2 NCAM-2 Precursor248NPTNC - Cellular Fate and Organizationpresynaptic membraneISScell surfaceIDAintegral component of membraneIEApositive regulation of fibroblast growth factor receptor signaling pathwayISSpositive regulation of neuron projection developmentISSpositive regulation of protein phosphorylationISSlong-term synaptic potentiationISSpositive regulation of cytosolic calcium ion concentrationISShomophilic cell adhesion via plasma membrane adhesion moleculesISStransmembrane receptor protein tyrosine kinase signaling pathwayIEApositive regulation of long-term neuronal synaptic plasticityISStype 1 fibroblast growth factor receptor bindingISStransmembrane receptor protein tyrosine kinase activityIEAATP bindingIEAcell adhesion molecule bindingISSNeuroplastin; Stromal cell-derived receptor 1; SDR-1; Precursor14702039153401611548933417196182191592181934997321269460NPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNPTNNeuroplastin Stromal cell-derived receptor 1 SDR-1 Precursor240PF4C - Cellular Fate and Organizationplatelet alpha granule lumenTASextracellular regionNASextracellular spaceIBAcytokine-mediated signaling pathwayIDAnegative regulation of megakaryocyte differentiationIDAimmune responseIBAinflammatory responseIBAregulation of cell proliferationIDApositive regulation of transcription from RNA polymerase II promoterIDAnegative regulation of MHC class II biosynthetic processIDAresponse to lipopolysaccharideIBAnegative regulation of extrinsic apoptotic signaling pathway in absence of ligandIDApositive regulation of cAMP metabolic processIDApositive regulation of cAMP-mediated signalingIDAchemokine-mediated signaling pathwayIBApositive regulation of tumor necrosis factor productionIDAleukocyte chemotaxisIDApositive regulation of macrophage derived foam cell differentiationIDAplatelet activationIDApositive regulation of macrophage differentiationIDApositive regulation of leukocyte chemotaxisIBApositive regulation of gene expressionIDAG-protein coupled receptor signaling pathwayIBAblood coagulationTASnegative regulation of cytolysisIDAplatelet degranulationTASnegative regulation of angiogenesisIDAchemokine activityTASCXCR3 chemokine receptor bindingIDAheparin bindingIDAPlatelet factor 4; PF-4; C-X-C motif chemokine 4; Iroplact; Oncostatin-A; Platelet factor 4, short form; Precursor11468158154893341581562116951122353618326792230983196017576445090754786776444968031770893407PLF4PF4PF4PF4PF4PF4PF4PF4PF4PF4PF4PF4PF4PF4PF4PF4PF4PF4PF4PF4PF4PF4PF4PF4PF4PF4PF4PF4PF4PF4PF4PF4PF4PF4PF4PF4PF4PF4PF4PF4PF4Platelet factor 4 PF-4 C-X-C motif chemokine 4 Iroplact Oncostatin-A Platelet factor 4, short form Precursor165MMP3C - Cellular Fate and OrganizationmitochondrionIEAproteinaceous extracellular matrixIEAextracellular regionTASextracellular spaceTAScytosolIEAregulation of cell migrationIEAnegative regulation of protein kinase B signalingIEAcellular response to nitric oxideTASnegative regulation of hydrogen peroxide metabolic processIDAprotein catabolic processIEAextracellular matrix disassemblyTAScellular response to amino acid stimulusIEAextracellular matrix organizationTAScollagen catabolic processTASproteolysisIDApositive regulation of protein oligomerizationIDApositive regulation of oxidative stress-induced cell deathISSendopeptidase activityIDAcalcium ion bindingIEAzinc ion bindingIEAmetalloendopeptidase activityTASStromelysin-1; SL-1; 3.4.24.17; Matrix metalloproteinase-3; MMP-3; Transin-1; Precursor10422833105439491247794114702039154893342383557303029033608033477804765601485352338662692874036090834939288970976024097920989827994MMP3MMP3MMP3MMP3MMP3MMP3MMP3MMP3MMP3MMP3MMP3MMP3MMP3MMP3MMP3MMP3MMP3MMP3MMP3Stromelysin-1 SL-1 3.4.24.17 Matrix metalloproteinase-3 MMP-3 Transin-1 Precursor252MMP2C - Cellular Fate and OrganizationmitochondrionIEAplasma membraneIEAproteinaceous extracellular matrixIEAnucleusIEAextracellular regionTASsarcomereIEAextracellular spaceIDAresponse to hypoxiaIEAephrin receptor signaling pathwayTASembryo implantationIEAangiogenesisIEAendodermal cell differentiationIEPbone trabecula formationIEAintramembranous ossificationIEAface morphogenesisIEApositive regulation of innate immune responseIEAextracellular matrix disassemblyTAScellular response to amino acid stimulusIEAaxon guidanceTASextracellular matrix organizationTAScollagen catabolic processTASproteolysisIDAblood vessel maturationIEAcellular protein metabolic processTASserine-type endopeptidase activityTASzinc ion bindingTASmetalloendopeptidase activityTAS72 kDa type IV collagenase; 3.4.24.24; 72 kDa gelatinase; Gelatinase A; Matrix metalloproteinase-2; MMP-2; TBE-1; PEX; Precursor10356396105453221055913711029402111793051132009011431697117105941175139211928808120322971214733912714657128790051470203914766804148004115489334156165531569136516392792165423931655733169599741743517518517241897160119493954215848421628312250927622905912283438375836648549817864677791190369476898MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP2MMP272 kDa type IV collagenase 3.4.24.24 72 kDa gelatinase Gelatinase A Matrix metalloproteinase-2 MMP-2 TBE-1 PEX Precursor247D - Genome Maintenancenegative regulation of cell proliferationTASpositive regulation of MAPK cascadeIEAtraversing start control point of mitotic cell cycleTASATP bindingIEAcyclin-dependent protein serine/threonine kinase activityTASCyclin-dependent kinase 10; 2.7.11.22; Cell division protein kinase 10; Serine/threonine-protein kinase PISSLRE100361891470203915489334156165531734484618669648186919762421857280846118208557CDK10CDK10CDK10CDK10CDK10CDK10CDK10CDK10CDK10CDK10CDK10CDK10CDK10CDK10CDK10CDK10CDK10CDK10CDK10CDK10CDK10CDK10CDK10CDK10CDK10CDK10CDK10Cyclin-dependent kinase 10 2.7.11.22 Cell division protein kinase 10 Serine/threonine-protein kinase PISSLRE227FSTL4N - Not Matchedextracellular regionIEAcalcium ion bindingIEAFollistatin-related protein 4; Follistatin-like protein 4; Precursor1047085115372022154893341552750717974005FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4FSTL4Follistatin-related protein 4 Follistatin-like protein 4 Precursor338F - Protein Fateblood microparticleIDAextracellular regionTASextracellular exosomeIDAcomplement activationTASinnate immune responseTAScomplement activation, classical pathwayTASserine-type endopeptidase activityIDAcalcium ion bindingIEAidentical protein bindingIPIComplement C1s subcomponent; 3.4.21.42; C1 esterase; Complement component 1 subcomponent s; Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain; Precursor107752601139051811527969127889221548933416335952185472519159218200712221412782427556924597022553984283194430071453500856636266177797749794427C1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SC1SComplement C1s subcomponent 3.4.21.42 C1 esterase Complement component 1 subcomponent s Complement C1s subcomponent heavy chain Complement C1s subcomponent light chain Precursor341AEBP1T - TranscriptioncytoplasmIEAnucleusIEAextracellular spaceIDAextracellular exosomeIDAskeletal system developmentTASmuscle organ developmentTASnegative regulation of transcription from RNA polymerase II promoterIMPtranscription factor activity, sequence-specific DNA bindingTASRNA polymerase II regulatory region sequence-specific DNA bindingIDAtranscription corepressor activityIEAcarboxypeptidase activityTASzinc ion bindingIEAtranscriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific bindingIDAmetallocarboxypeptidase activityIEAAdipocyte enhancer-binding protein 1; AE-binding protein 1; Aortic carboxypeptidase-like protein; Precursor126902051470203915489334191592182427556989209289624159AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1AEBP1Adipocyte enhancer-binding protein 1 AE-binding protein 1 Aortic carboxypeptidase-like protein Precursor165SASH1C - Cellular Fate and Organizationprotein complexIMPmembraneIEApositive regulation of endothelial cell migrationIDAprotein polyubiquitinationIDApositive regulation of NIK/NF-kappaB signalingIMPpositive regulation of p38MAPK cascadeIMPregulation of protein autoubiquitinationIDApositive regulation of lipopolysaccharide-mediated signaling pathwayIMPpositive regulation of JUN kinase activityIMPregulation of protein K63-linked ubiquitinationIDApositive regulation of angiogenesisIMPprotein complex scaffoldIDAprotein kinase bindingIDAmitogen-activated protein kinase kinase kinase bindingIDAprotein C-terminus bindingIDASAM and SH3 domain-containing protein 1; Proline-glutamate repeat-containing protein12771949145744041470203915489334170819831866964821406692242755699872452SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SASH1SAM and SH3 domain-containing protein 1 Proline-glutamate repeat-containing protein181ZMYND11D - Genome MaintenancechromosomeIEAnucleoplasmIDAnucleusTASnegative regulation of extrinsic apoptotic signaling pathwayIMPcell cycleIEAnegative regulation of JNK cascadeIMPcell proliferationTASviral processIEAnegative regulation of transcription from RNA polymerase II promoterTASregulation of transcription elongation from RNA polymerase II promoterISStranscription, DNA-templatedIEAnegative regulation of I-kappaB kinase/NF-kappaB signalingIMPchromatin modificationIEAtranscription corepressor activityISSzinc ion bindingISSmethylated histone bindingISSDNA bindingIEAZinc finger MYND domain-containing protein 11; Adenovirus 5 E1A-binding protein; Bone morphogenetic protein receptor-associated molecule 1; Protein BS69107343131173352812181323147020391516405415489334159477841638213716565076175253321866964819379743197666262006823120138174233727602391519524590075252179587621829ZMY11ZMYND11ZMYND11ZMYND11ZMYND11ZMYND11ZMYND11ZMYND11ZMYND11ZMYND11ZMYND11ZMYND11ZMYND11ZMYND11ZMYND11ZMYND11ZMYND11ZMYND11ZMYND11ZMYND11ZMYND11ZMYND11ZMYND11ZMYND11ZMYND11ZMYND11ZMYND11Zinc finger MYND domain-containing protein 11 Adenovirus 5 E1A-binding protein Bone morphogenetic protein receptor-associated molecule 1 Protein BS69169PRTN3C - Cellular Fate and Organizationplasma membraneIDAextracellular spaceIDAextracellular exosomeIDAcytosolIDAnegative regulation of phagocytosisIDApositive regulation of cell proliferationTASblood coagulationTAScollagen catabolic processIEAmature conventional dendritic cell differentiationIDAserine-type endopeptidase activityIEAserine-type peptidase activityTASenzyme bindingIPIMyeloblastin; 3.4.21.76; AGP7; C-ANCA antigen; Leukocyte proteinase 3; PR-3; PR3; Neutrophil proteinase 4; NP-4; P29; Wegener autoantigen; Precursor1400430150578241518849154893341681549168861220014632033050212116221269460224243622587012285532237722824049772501794259826726799107539799789724587572939924693PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3PRTN3Myeloblastin 3.4.21.76 AGP7 C-ANCA antigen Leukocyte proteinase 3 PR-3 PR3 Neutrophil proteinase 4 NP-4 P29 Wegener autoantigen Precursor267ELANEC - Cellular Fate and OrganizationcytoplasmIDAcell surfaceIDAtranscriptional repressor complexIDAextracellular regionNASsecretory granuleIDAextracellular exosomeIDAphagocytosisIEAacute inflammatory response to antigenic stimulusIEAleukocyte migrationIEAresponse to yeastIEAprotein catabolic processNASnegative regulation of chemotaxisNASextracellular matrix disassemblyTASextracellular matrix organizationTASpositive regulation of MAP kinase activityNAScollagen catabolic processTASnegative regulation of chemokine biosynthetic processIDAresponse to lipopolysaccharideIEAproteolysisIDAnegative regulation of growth of symbiont in hostIEAresponse to UVIDAneutrophil mediated killing of fungusIEAdefense response to bacteriumIDAnegative regulation of interleukin-8 biosynthetic processIDApositive regulation of interleukin-8 biosynthetic processIDAcellular calcium ion homeostasisNASnegative regulation of transcription from RNA polymerase II promoterIMPpositive regulation of smooth muscle cell proliferationIDApositive regulation of immune responseIEAnegative regulation of inflammatory responseNAScytokine bindingIPIendopeptidase activityIDAserine-type endopeptidase activityIEARNA polymerase II transcription corepressor activityIMPpeptidase activityIDAprotease bindingIPIheparin bindingIDANeutrophil elastase; 3.4.21.37; Bone marrow serine protease; Elastase-2; Human leukocyte elastase; HLE; Medullasin; PMN elastase; Precursor1058103011001877116753331209137114673143149629021514002215489334174363131859409189466701903607619159218194150091992729120220065208031422126946021425445232227823463630246243425017942775493282267729020872911584339128034222323479752355080836407097897245ELNEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANEELANENeutrophil elastase 3.4.21.37 Bone marrow serine protease Elastase-2 Human leukocyte elastase HLE Medullasin PMN elastase Precursor165HRCA - Transport and SensingZ discIDAsarcoplasmic reticulum lumenTASsarcoplasmic reticulum membraneIEApositive regulation of relaxation of cardiac muscleIGIregulation of calcium ion transmembrane transportIGIcytosolic calcium ion homeostasisIGIregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionTASregulation of cell communication by electrical coupling involved in cardiac conductionIGImuscle contractionTASregulation of heart rateIMPregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumIGIregulation of ryanodine-sensitive calcium-release channel activityIGIregulation of peptidyl-serine phosphorylationIGIpositive regulation of heart rateIGIpositive regulation of heart contractionIGIcalcium ion bindingIDAATPase bindingIPIion channel bindingIPISarcoplasmic reticulum histidine-rich calcium-binding protein; Precursor15489334203729324275569SRCHHRCHRCHRCHRCHRCHRCHRCHRCSarcoplasmic reticulum histidine-rich calcium-binding protein Precursor339NELL2N - Not Matchedextracellular regionIEAneuron cellular homeostasisISScalcium ion bindingIEAProtein kinase C-binding protein NELL2; NEL-like protein 2; Nel-related protein 2; Precursor147020391534016115489334165410758975702NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2NELL2Protein kinase C-binding protein NELL2 NEL-like protein 2 Nel-related protein 2 Precursor166MAFBC - Cellular Fate and Organizationtranscription factor complexIEAnucleusTAST cell differentiation in thymusIEAinner ear morphogenesisIEAsegment specificationIEArespiratory gaseous exchangeIEAthymus developmentIEAtranscription, DNA-templatedIEAsensory organ developmentTASrhombomere 6 developmentIEArhombomere 5 developmentIEAnegative regulation of erythrocyte differentiationIDAbrain segmentationIEApositive regulation of transcription from RNA polymerase II promoterIEAsequence-specific DNA bindingIEAtranscription factor activity, sequence-specific DNA bindingIEAtranscription factor bindingIDATranscription factor MafB; Maf-B; V-maf musculoaponeurotic fibrosarcoma oncogene homolog B104443281178005214702039151350461548933415963504180424541914305322387013MAFBMAFBMAFBMAFBMAFBMAFBMAFBMAFBMAFBMAFBMAFBTranscription factor MafB Maf-B V-maf musculoaponeurotic fibrosarcoma oncogene homolog B208C - Cellular Fate and OrganizationcytoplasmIEAribonucleoprotein complexIDAnucleusIBAsignal transductionTASregulation of transcription from RNA polymerase II promoterIBAtranscription from RNA polymerase II promoterIBAcell proliferationTASmulticellular organismal developmentTASprotein phosphorylationTAScell differentiationIBAsequence-specific DNA bindingIEARNA polymerase II transcription factor activity, sequence-specific DNA bindingIBAsignal transducer activityTASDNA bindingTASTranscriptional regulator ERG; Transforming protein ERG14693372147020391535164915489334163031801728966132997083476934807634481870698290279ERGERGERGERGERGERGERGERGERGERGERGERGERGERGERGERGERGERGERGERGERGERGERGERGERGERGERGERGERGERGERGTranscriptional regulator ERG Transforming protein ERG165CNTN3C - Cellular Fate and Organizationplasma membraneIEAanchored component of membraneIEAcell adhesionIEAnervous system developmentIEAContactin-3; Brain-derived immunoglobulin superfamily protein 1; BIG-1; Plasmacytoma-associated neuronal glycoprotein; Precursor10819331110130811548933416335952166419971797400520133774CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3CNTN3Contactin-3 Brain-derived immunoglobulin superfamily protein 1 BIG-1 Plasmacytoma-associated neuronal glycoprotein Precursor366ELAVL1C - Cellular Fate and OrganizationcytoplasmIDAmembraneIDAnucleusIDAnucleoplasmTAScytosolTASgene expressionTASmulticellular organismal developmentTASpositive regulation of translationIDAmRNA stabilizationIMP3'-UTR-mediated mRNA stabilizationIDAregulation of stem cell population maintenanceISSdouble-stranded RNA bindingIDApoly(A) RNA bindingIDAnucleotide bindingIEAprotein kinase bindingIPIRNA bindingIDAAU-rich element bindingIDAmRNA 3'-UTR bindingISSmRNA bindingTASmRNA 3'-UTR AU-rich region bindingIDAELAV-like protein 1; Hu-antigen R; HuR1172930912237300145172881470203915057824154893341708198317924679179325091822033618669648190293031956159419690332200682312126946021406692236409428626503ELAV1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAVL1ELAV-like protein 1 Hu-antigen R HuR181NEGR1C - Cellular Fate and Organizationneuron projectionIBAplasma membraneIBAcell surfaceIBAcell-cell junctionIBAneuronal cell bodyIBAanchored component of membraneIEAextracellular exosomeIDAfeeding behaviorIEAsingle organismal cell-cell adhesionIBAregulation of neurogenesisIBApositive regulation of neuron projection developmentIEAlocomotory behaviorIEANeuronal growth regulator 1; IgLON family member 4; Precursor129753091470203915489334166027011671041417974005NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1NEGR1Neuronal growth regulator 1 IgLON family member 4 Precursor181NR0B1D - Genome MaintenancecytoplasmIDAmembraneIDApolysomal ribosomeIDAnucleoplasmTASnucleusIDAgonad developmentIMPresponse to immobilization stressIEAgene expressionTASsteroid biosynthetic processIDAtranscription initiation from RNA polymerase II promoterTASadrenal gland developmentIMPpituitary gland developmentNASnegative regulation of intracellular steroid hormone receptor signaling pathwayIDAnegative regulation of transcription from RNA polymerase II promoterIEAspermatogenesisIEAhypothalamus developmentNASnegative regulation of sequence-specific DNA binding transcription factor activityIMPSertoli cell differentiationIEAprotein localizationIDAmale sex determinationIEALeydig cell differentiationIEAnegative regulation of cell differentiationIEAintracellular receptor signaling pathwayIDAnegative regulation of transcription, DNA-templatedIDAmale gonad developmentIMPRNA bindingIDAtranscription corepressor activityIMPprotein domain specific bindingIPIsteroid hormone receptor bindingIPIsteroid hormone receptor activityIEAAF-2 domain bindingIPIDNA hairpin bindingIDADNA bindingIDAprotein homodimerization activityIPIsequence-specific DNA bindingIDARNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA bindingNAStranscription factor bindingIPINuclear receptor subfamily 0 group B member 1; DSS-AHC critical region on the X chromosome protein 1; Nuclear receptor DAX-110323730103418581067535810713076108486161111384811443184117488521178862112482977126291281548933415589120158009031614670316709599799095379909588675564900350090634319360549941539994866449529340NR0B1NR0B1NR0B1NR0B1NR0B1NR0B1NR0B1NR0B1NR0B1NR0B1NR0B1NR0B1NR0B1NR0B1NR0B1NR0B1NR0B1NR0B1NR0B1NR0B1NR0B1NR0B1NR0B1Nuclear receptor subfamily 0 group B member 1 DSS-AHC critical region on the X chromosome protein 1 Nuclear receptor DAX-1306PTPRUC - Cellular Fate and Organizationplasma membraneTAScell-cell junctionIDAintegral component of plasma membraneNASnegative regulation of cell migrationIDAnegative regulation of cell proliferationIDAorgan regenerationIEAresponse to glucocorticoidIEAcell differentiationIEApeptidyl-tyrosine dephosphorylationIDAsingle organismal cell-cell adhesionIDAhomotypic cell-cell adhesionIEAprotein dephosphorylationIDAprotein localization to cell surfaceIDAtransmembrane receptor protein tyrosine phosphatase signaling pathwayNAScell adhesionNAScanonical Wnt signaling pathwayIDAbeta-catenin bindingIPItransmembrane receptor protein tyrosine phosphatase activityNASprotein tyrosine phosphatase activityIDAReceptor-type tyrosine-protein phosphatase U; R-PTP-U; 3.1.3.48; Pancreatic carcinoma phosphatase 2; PCP-2; Protein-tyrosine phosphatase J; PTP-J; hPTP-J; Protein-tyrosine phosphatase pi; PTP pi; Protein-tyrosine phosphatase receptor omicron; PTP-RO; Receptor-type protein-tyrosine phosphatase psi; R-PTP-psi; Precursor1039594410397721125012151548933416574648167104141695997417622474196903328700514887067590702239434160PTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUPTPRUReceptor-type tyrosine-protein phosphatase U R-PTP-U 3.1.3.48 Pancreatic carcinoma phosphatase 2 PCP-2 Protein-tyrosine phosphatase J PTP-J hPTP-J Protein-tyrosine phosphatase pi PTP pi Protein-tyrosine phosphatase receptor omicron PTP-RO Receptor-type protein-tyrosine phosphatase psi R-PTP-psi Precursor171TDRKHD - Genome MaintenancemitochondrionISSpi-bodyISSpiP-bodyISSfertilizationISSgene expressionTASpiRNA metabolic processISSgene silencing by RNAIEAspermatogenesisISScell differentiationIEADNA methylation involved in gamete generationISSmale meiosisISSRNA bindingIEATudor and KH domain-containing protein; Tudor domain-containing protein 210767542154893341671041424275569TDRKHTDRKHTDRKHTDRKHTDRKHTDRKHTDRKHTDRKHTDRKHTDRKHTDRKHTDRKHTDRKHTDRKHTDRKHTDRKHTDRKHTDRKHTDRKHTDRKHTDRKHTDRKHTDRKHTudor and KH domain-containing protein Tudor domain-containing protein 2165CLIP4CAP-Gly domain-containing linker protein 4; Restin-like protein 2147020391548933417974005CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CLIP4CAP-Gly domain-containing linker protein 4 Restin-like protein 2201SHC3C - Cellular Fate and Organizationplasma membraneIBAcytosolTASinsulin receptor signaling pathwayTASneurotrophin TRK receptor signaling pathwayTASepidermal growth factor receptor signaling pathwayTASsynaptic transmission, glutamatergicIEAlearning or memoryIEARas protein signal transductionTAScentral nervous system developmentTAStransmembrane receptor protein tyrosine kinase signaling pathwayTASreceptor tyrosine kinase bindingIBAprotein kinase bindingIBAsignal transducer activityTASSHC-transforming protein 3; Neuronal Shc; N-Shc; Protein Rai; SHC-transforming protein C; Src homology 2 domain-containing-transforming protein C3; SH2 domain protein C312006576151640531548933487603058808684SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC3SHC-transforming protein 3 Neuronal Shc N-Shc Protein Rai SHC-transforming protein C Src homology 2 domain-containing-transforming protein C3 SH2 domain protein C3319ZEB2C - Cellular Fate and OrganizationnucleusIDAcell proliferation in forebrainIEAmelanocyte migrationISSpositive regulation of melanin biosynthetic processICsomitogenesisIEAneural crest cell migrationIEAneural tube closureIEApositive regulation of Wnt signaling pathwayIEAregulation of melanosome organizationISSnegative regulation of transcription from RNA polymerase II promoterIMPtranscription, DNA-templatedIEAnervous system developmentNAShippocampus developmentIEApositive regulation of transcription from RNA polymerase II promoterIMPpositive regulation of JUN kinase activityIEApositive regulation of melanocyte differentiationISSdevelopmental pigmentationISSphosphatase regulator activityNASDNA bindingIEAmetal ion bindingIEAZinc finger E-box-binding homeobox 2; Smad-interacting protein 1; SMADIP1; Zinc finger homeobox protein 1b11279515114489421245121414702039153840971548933415815621160614791668875116959974196088612427556996285819853615ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2ZEB2Zinc finger E-box-binding homeobox 2 Smad-interacting protein 1 SMADIP1 Zinc finger homeobox protein 1b179TWIST1D - Genome MaintenancenucleusIDAaortic valve morphogenesisIMPtranscription from RNA polymerase II promoterIDAmitral valve morphogenesisIEAembryonic cranial skeleton morphogenesisIMPpositive regulation of cell motilityIMPcell proliferation involved in heart valve developmentIMPpositive regulation of monocyte chemotactic protein-1 productionIMPpositive regulation of epithelial cell proliferationIEAregulation of bone mineralizationIMPpositive regulation of tumor necrosis factor productionIMPnegative regulation of tumor necrosis factor productionIEAneural tube closureIEAnegative regulation of phosphatidylinositol 3-kinase signalingIMPnegative regulation of transcription from RNA polymerase II promoterIMPnegative regulation of skeletal muscle tissue developmentIEAin utero embryonic developmentIEAosteoblast differentiationIEAmuscle organ developmentIEAossificationTASrhythmic processIEAnegative regulation of oxidative phosphorylation uncoupler activityIEAnegative regulation of transcription, DNA-templatedISSembryonic digit morphogenesisTASnegative regulation of double-strand break repairIMPpositive regulation of transcription regulatory region DNA bindingIMPpositive regulation of epithelial to mesenchymal transitionIMPnegative regulation of peroxisome proliferator activated receptor signaling pathwayIEAnegative regulation of histone acetylationIEAnegative regulation of sequence-specific DNA binding transcription factor activityIEApositive regulation of interleukin-6 secretionIMPpositive regulation of transcription from RNA polymerase II promoterIDAeyelid development in camera-type eyeIMPodontogenesisIEApalate developmentIEAouter ear morphogenesisTASnegative regulation of cellular senescenceIMPembryonic camera-type eye formationIMPnegative regulation of apoptotic processIEApositive regulation of endocardial cushion to mesenchymal transition involved in heart valve formationIEAendocardial cushion morphogenesisIEAcellular response to hypoxiaIMPpositive regulation of angiogenesisNASpositive regulation of gene expressionIMPnegative regulation of histone phosphorylationIMPnegative regulation of osteoblast differentiationIMPcranial suture morphogenesisTAScellular response to growth factor stimulusIEAembryonic hindlimb morphogenesisIEApositive regulation of fatty acid beta-oxidationIMPnegative regulation of DNA damage response, signal transduction by p53 class mediatorIMPcardiac neural crest cell migration involved in outflow tract morphogenesisIEAembryonic forelimb morphogenesisIEAneuron migrationIEARNA polymerase II transcription factor activity, sequence-specific DNA bindingIDAbHLH transcription factor bindingIPIE-box bindingIDAtranscription factor bindingIPITwist-related protein 1; Class A basic helix-loop-helix protein 38; bHLHa38; H-twist11754069125539061269020512853948154893341734326989881668988167899576590730709215678TWST1TWIST1TWIST1TWIST1TWIST1TWIST1TWIST1TWIST1TWIST1TWIST1TWIST1TWIST1TWIST1TWIST1TWIST1TWIST1TWIST1TWIST1TWIST1TWIST1TWIST1TWIST1TWIST1TWIST1TWIST1TWIST1TWIST1TWIST1TWIST1TWIST1TWIST1TWIST1TWIST1TWIST1TWIST1TWIST1TWIST1Twist-related protein 1 Class A basic helix-loop-helix protein 38 bHLHa38 H-twist199NTN3C - Cellular Fate and OrganizationGolgi apparatusIEAproteinaceous extracellular matrixIEAmuscle cell differentiationTASpositive regulation of muscle cell differentiationTASaxon guidanceNASNetrin-3; Netrin-2-like protein; Precursor88280419143507NET3NTN3NTN3NTN3NTN3NTN3NTN3NTN3NTN3NTN3NTN3NTN3NTN3NTN3NTN3NTN3NTN3NTN3NTN3NTN3NTN3NTN3NTN3NTN3NTN3NTN3NTN3NTN3NTN3NTN3NTN3NTN3NTN3NTN3NTN3NTN3NTN3NTN3NTN3Netrin-3 Netrin-2-like protein Precursor206C - Cellular Fate and Organizationprotein complexIDAcytoplasmIDAnuclear speckIDAnucleoplasmIDAnucleusIDAintracellular membrane-bounded organelleIDAcytosolISSpositive regulation of cardiac muscle cell proliferationISSregulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activityISSsecondary heart field specificationISSregulation of N-methyl-D-aspartate selective glutamate receptor activityISScellular response to trichostatin AISScellular response to transforming growth factor beta stimulusIDAprimary heart field specificationISSembryonic viscerocranium morphogenesisIEAstress-activated MAPK cascadeTASheart developmentIEPregulation of megakaryocyte differentiationISSchondrocyte differentiationISSMAPK cascadeIDAneural crest cell differentiationISSpositive regulation of cell proliferation in bone marrowIEAgerminal center formationISSregulation of dendritic spine developmentISSregulation of synaptic transmission, glutamatergicISSmyotube differentiationIEPregulation of synapse assemblyISSpositive regulation of bone mineralizationISSglomerulus morphogenesisISSregulation of neurotransmitter secretionISSmuscle cell fate determinationISSpositive regulation of skeletal muscle tissue developmentIMPmuscle organ developmentTASpositive regulation of muscle cell differentiationTASskeletal muscle tissue developmentISSresponse to ischemiaISSinnate immune responseTASpositive regulation of alkaline phosphatase activityISStoll-like receptor 10 signaling pathwayTAScartilage morphogenesisIEAtoll-like receptor 9 signaling pathwayTASsmooth muscle cell differentiationISSB cell receptor signaling pathwayISSB cell homeostasisISSpositive regulation of B cell proliferationISScell morphogenesis involved in neuron differentiationISSB cell proliferationISSneuron developmentISSneuron differentiationIEPhumoral immune responseISScellular response to parathyroid hormone stimulusIDAcellular response to calcium ionISSmonocyte differentiationIEApositive regulation of behavioral fear responseISSplatelet formationISSneurotrophin TRK receptor signaling pathwayTASblood vessel developmentISSresponse to virusIEPpositive regulation of macrophage apoptotic processISScellular response to drugISSnervous system developmentTASpositive regulation of osteoblast differentiationISSblood vessel remodelingISSpositive regulation of neuron differentiationISSpositive regulation of myoblast differentiationIMPneuron migrationISStranscription from RNA polymerase II promoterIDAventricular cardiac muscle cell differentiationISSnegative regulation of epithelial cell proliferationIEAsinoatrial valve morphogenesisISSheart loopingISSmuscle cell differentiationTASrenal tubule morphogenesisISSMyD88-independent toll-like receptor signaling pathwayTASregulation of neuron apoptotic processISSnegative regulation of neuron apoptotic processISSregulation of synaptic plasticityISSMyD88-dependent toll-like receptor signaling pathwayTASepithelial cell proliferation involved in renal tubule morphogenesisISSlearning or memoryISSpositive regulation of skeletal muscle cell differentiationIDAtoll-like receptor TLR6:TLR2 signaling pathwayTAStoll-like receptor TLR1:TLR2 signaling pathwayTAStoll-like receptor 2 signaling pathwayTASexcitatory postsynaptic potentialISSnegative regulation of transcription from RNA polymerase II promoterIMPtoll-like receptor signaling pathwayTASosteoblast differentiationISSpositive regulation of cardiac muscle cell differentiationIDAendochondral ossificationISSTRIF-dependent toll-like receptor signaling pathwayTASpositive regulation of transcription, DNA-templatedIDAnephron tubule epithelial cell differentiationISStoll-like receptor 4 signaling pathwayTASnegative regulation of ossificationIDApositive regulation of MAP kinase activityISSpositive regulation of transcription from RNA polymerase II promoterIDAcardiac muscle hypertrophy in response to stressIEApalate developmentIEAtoll-like receptor 3 signaling pathwayTASregulation of synaptic activityISSregulation of germinal center formationISSregulation of transcription, DNA-templatedIDApositive regulation of protein homodimerization activityISSapoptotic processIEAmelanocyte differentiationISSoutflow tract morphogenesisISScellular response to fluid shear stressISSpositive regulation of gene expressionIDAcellular response to lipopolysaccharideISScardiac ventricle formationISSnegative regulation of gene expressionISSregulation of sarcomere organizationIEAtoll-like receptor 5 signaling pathwayTASRNA polymerase II regulatory region sequence-specific DNA bindingIDAtranscription factor activity, sequence-specific DNA bindingIDAprotein heterodimerization activityIPItranscription factor activity, RNA polymerase II core promoter sequence-specificIDAtranscription regulatory region DNA bindingISSRNA polymerase II transcription factor activity, sequence-specific DNA bindingISStranscriptional activator activity, RNA polymerase II distal enhancer sequence-specific bindingIEARNA polymerase II core promoter proximal region sequence-specific DNA bindingIEADNA bindingIDAtranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingIDAmiRNA bindingIDAAT DNA bindingIDAchromatin bindingIEARNA polymerase II distal enhancer sequence-specific DNA bindingIEAcore promoter sequence-specific DNA bindingIEAactivating transcription factor bindingIPIMyocyte-specific enhancer factor 2C1052367010849446115358321190444315340086153720221556171815743823158314631583413116478538179740051959239076795088455629906929093845849798649MEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMEF2CMyocyte-specific enhancer factor 2C188C - Cellular Fate and Organizationazurophil granuleIDAextracellular regionNASextracellular exosomeIDAnegative regulation of apoptotic processNASglial cell migrationIDApositive regulation of tumor necrosis factor biosynthetic processIDApositive regulation of interleukin-1 beta biosynthetic processIDAprotein kinase C-activating G-protein coupled receptor signaling pathwayTASpositive regulation of cell adhesionIDApositive regulation of MHC class II biosynthetic processIEPinduction of positive chemotaxisNASdefense response to Gram-negative bacteriumTASimmune responseIBApositive regulation of phagocytosisIDAinflammatory responseNASpositive regulation of fractalkine biosynthetic processIDAmonocyte activationTASprotein processingIBAcellular extravasationNASregulation of vascular permeabilityNASmacrophage chemotaxisNASmicroglial cell activationIEPserine-type endopeptidase activityIBAtoxic substance bindingNASheparin bindingNASAzurocidin; Cationic antimicrobial protein CAP37; Heparin-binding protein; HBP; Precursor139900815057824151884915489334175538318979551915921819190111937776202617220490912126946022268322332502240497724065272501794850632790951939761855CAP7AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1AZU1Azurocidin Cationic antimicrobial protein CAP37 Heparin-binding protein HBP Precursor206ABI1C - Cellular Fate and OrganizationSCAR complexIDAcell junctionIEAendoplasmic reticulumTASpostsynaptic densityIEAnucleusIEAfilopodiumIDAlamellipodiumIDAgrowth coneIEAcytosolTASintracellularIDApostsynaptic membraneIEAcytoskeletonIEAextracellular exosomeIDAvascular endothelial growth factor receptor signaling pathwayTASlamellipodium morphogenesisIEAmegakaryocyte developmentIEAnegative regulation of cell proliferationTASactin polymerization or depolymerizationNASsomitogenesisIEAinnate immune responseTASmovement of cell or subcellular componentIDApeptidyl-tyrosine phosphorylationIDAtransmembrane receptor protein tyrosine kinase signaling pathwayTASFc-gamma receptor signaling pathway involved in phagocytosisTAScytoskeletal protein bindingTASprotein tyrosine kinase activator activityIEAprotein complex bindingIDAAbl interactor 1; Abelson interactor 1; Abi-1; Abl-binding protein 4; AblBP4; Eps8 SH3 domain-binding protein; Eps8-binding protein; Nap1-binding protein; Nap1BP; Spectrin SH3 domain-binding protein 1; e3B1110036551141823712665801126815071470203915164054154893341708198318088087183282681866964818691976200682312126946021406692222238952281437824275569901022595937099694699ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1ABI1Abl interactor 1 Abelson interactor 1 Abi-1 Abl-binding protein 4 AblBP4 Eps8 SH3 domain-binding protein Eps8-binding protein Nap1-binding protein Nap1BP Spectrin SH3 domain-binding protein 1 e3B1302SHC1D - Genome Maintenanceplasma membraneIDAShc-EGFR complexISSmitochondrial matrixIEAcytosolTASinsulin receptor signaling pathwayISSpositive regulation of cell proliferationNASRas protein signal transductionTASleukocyte migrationTASendoplasmic reticulum unfolded protein responseTASheart developmentIEAactivation of MAPK activityIDAsingle organismal cell-cell adhesionIEAepidermal growth factor receptor signaling pathwayTASMAPK cascadeIDAregulation of epidermal growth factor-activated receptor activityTASneurotrophin TRK receptor signaling pathwayTASactin cytoskeleton reorganizationIEApositive regulation of DNA replicationISSplatelet activationTASpeptidyl-tyrosine phosphorylationTASangiogenesisIEAblood coagulationTASfibroblast growth factor receptor signaling pathwayTASinnate immune responseTASactivation of signaling protein activity involved in unfolded protein responseTAScellular protein metabolic processTASregulation of growthIEAFc-epsilon receptor signaling pathwayTASepidermal growth factor receptor bindingISSphospholipid bindingTASprotein kinase bindingIBAephrin receptor bindingIPIneurotrophin TRKA receptor bindingIPIinsulin-like growth factor receptor bindingIPIinsulin receptor bindingIPItransmembrane receptor protein tyrosine kinase adaptor activityTASprotein tyrosine kinase activityTASSHC-transforming protein 1; SHC-transforming protein 3; SHC-transforming protein A; Src homology 2 domain-containing-transforming protein C1; SH2 domain protein C1101944511086702411349134119481811198067112925710145736191466564014702039151028291527200315316024154887581548933415526160155924551583779716235251671041417081983172749881866964819054851191727381936919519690332200682312126946021406692228143782427556974737627537849754104575440027559478815532681951718524391887417989396058940081903821090493009121430914893591928599233773948847995668779660833SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC1SHC-transforming protein 1 SHC-transforming protein 3 SHC-transforming protein A Src homology 2 domain-containing-transforming protein C1 SH2 domain protein C1184SREBF1C - Cellular Fate and Organizationprotein complexIEAER to Golgi transport vesicle membraneIEAcytoplasmISSGolgi membraneTASendoplasmic reticulumIDAendoplasmic reticulum membraneTASnucleoplasmTASnucleusIDAnuclear envelopeTASintegral component of membraneIEAcytosolTASinsulin receptor signaling pathwayIEAlipid metabolic processTASlung developmentIEAsmall molecule metabolic processTASresponse to cAMPIEAresponse to foodIEAcellular response to fatty acidIEAresponse to glucagonIEApositive regulation of transcription from RNA polymerase II promoterIDAresponse to retinoic acidIEAnegative regulation of insulin secretionIEAcellular lipid metabolic processTAScellular response to starvationISScholesterol metabolic processIEAregulation of heart rate by chemical signalIEAlipid biosynthetic processISSpositive regulation of triglyceride biosynthetic processISSregulation of transcription from RNA polymerase II promoterTASresponse to drugIEAagingIEAnegative regulation of transcription from RNA polymerase II promoterIEAregulation of fatty acid metabolic processIEAtranscription, DNA-templatedIEAresponse to glucoseIEApositive regulation of histone deacetylationIEAresponse to progesteroneIEAcircadian rhythmTASpositive regulation of cholesterol biosynthetic processIEAsequence-specific DNA bindingIEAtranscription factor activity, sequence-specific DNA bindingIDAsterol response element bindingIDAchromatin bindingIEADNA bindingISSSterol regulatory element-binding protein 1; SREBP-1; Class D basic helix-loop-helix protein 1; bHLHd1; Sterol regulatory element-binding transcription factor 1; Processed sterol regulatory element-binding protein 1154893341662519618267114186696487759101840289786266109634703SRBP1SREBF1SREBF1SREBF1SREBF1SREBF1SREBF1SREBF1SREBF1SREBF1SREBF1SREBF1SREBF1SREBF1SREBF1SREBF1SREBF1SREBF1SREBF1SREBF1SREBF1SREBF1SREBF1SREBF1SREBF1SREBF1SREBF1SREBF1SREBF1SREBF1SREBF1SREBF1SREBF1SREBF1SREBF1SREBF1SREBF1Sterol regulatory element-binding protein 1 SREBP-1 Class D basic helix-loop-helix protein 1 bHLHd1 Sterol regulatory element-binding transcription factor 1 Processed sterol regulatory element-binding protein 1170RNF103F - Protein Fateendoplasmic reticulumIDAendoplasmic reticulum membraneIEAintegral component of membraneIEAprotein ubiquitinationIDAER-associated ubiquitin-dependent protein catabolic processIDAcentral nervous system developmentTASubiquitin-protein transferase activityIDAligase activityIEAzinc ion bindingIEAE3 ubiquitin-protein ligase RNF103; 6.3.2.-; KF-1; hKF-1; RING finger protein 103; Zinc finger protein 103 homolog; Zfp-10310500182147020391548933415815621186752489070305RN103RNF103RNF103RNF103RNF103RNF103RNF103RNF103RNF103RNF103RNF103RNF103RNF103RNF103RNF103RNF103RNF103E3 ubiquitin-protein ligase RNF103 6.3.2.- KF-1 hKF-1 RING finger protein 103 Zinc finger protein 103 homolog Zfp-103204C - Cellular Fate and Organizationphotoreceptor inner segmentIEAcytoplasmIDAapical plasma membraneISSpericiliary membrane compartmentIEAstereocilium membraneISSstereocilia ankle link complexISSphotoreceptor connecting ciliumIEAstereocilium bundleISSintegral component of membraneIEAbasement membraneIDAhair cell differentiationISSinner ear receptor cell differentiationISSsensory perception of soundIMPphotoreceptor cell maintenanceIMPmaintenance of organ identityIMPvisual perceptionIEAresponse to stimulusIEAsensory perception of light stimulusIMPcollagen bindingIDAmyosin bindingISSUsherin; Usher syndrome type IIa protein; Usher syndrome type-2A protein; Precursor1072911310738000107755291090984911311042117881941211266412427073124333961252555612786748146762761497084315015129150257211524180115325563160980081611488816301216163012171643448016710414170856811729689817405132182738981845239418826961196839991973728420309401204400712050792421248752215937432168632921835308220048872233437023737954242279149624053USH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUSH2AUsherin Usher syndrome type IIa protein Usher syndrome type-2A protein Precursor409D - Genome Maintenanceplasma membraneTASintegral component of plasma membraneISSregulation of cell migrationNASNotch receptor processingTASgamma-delta T cell differentiationIEAepithelial cell apoptotic process involved in palatal shelf morphogenesisIEAspermatogenesisIEPregulation of cell adhesionIEAin utero embryonic developmentIEAcell differentiationIDAcell cycleNASrespiratory system processIEAskeletal system developmentIEAauditory receptor cell fate commitmentISST cell differentiationIDAmorphogenesis of embryonic epitheliumIEANotch signaling pathwayNASregulation of cell proliferationIDAthymic T cell selectionIDAodontogenesis of dentin-containing toothIEAcalcium ion bindingIEANotch bindingIPIgrowth factor activityIDAProtein jagged-2; Jagged2; hJ2; Precursor100792561066255293156659486542JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2JAG2Protein jagged-2 Jagged2 hJ2 Precursor226C - Cellular Fate and OrganizationaxonNASplasma membraneNASextracellular regionIEAanchored component of membraneIEAaxonal fasciculationTASnegative regulation of neuron differentiationIMPaxon guidanceTASbrain developmentISSregulation of synaptic plasticityTASaxonogenesisTASneuron projection developmentISSneuron cell-cell adhesionTASnervous system developmentIMPContactin-4; Brain-derived immunoglobulin superfamily protein 2; BIG-2; Precursor11013081122029911457113114702039151061221548933416335952166419971695997420133774CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4CNTN4Contactin-4 Brain-derived immunoglobulin superfamily protein 2 BIG-2 Precursor183HGFD - Genome MaintenancemembraneIDAplatelet alpha granule lumenTASextracellular regionTASextracellular spaceIEApositive regulation of DNA biosynthetic processIDAorgan regenerationIEApositive regulation of peptidyl-tyrosine phosphorylationIDAepithelial to mesenchymal transitionTASactivation of MAPK activityIEAregulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingIDAnegative regulation of release of cytochrome c from mitochondriaIDApositive regulation of neuron projection regenerationIEAcellular response to hepatocyte growth factor stimulusIDApositive regulation of transcription from RNA polymerase II promoterNASnegative regulation of cysteine-type endopeptidase activity involved in apoptotic processIDApositive regulation of myelinationIEApositive regulation of cell migrationIDAhepatocyte growth factor receptor signaling pathwayIDAplatelet activationTASpositive regulation of phosphatidylinositol 3-kinase signalingIDAnegative regulation of extrinsic apoptotic signaling pathway via death domain receptorsIEApositive regulation of angiogenesisIEApositive chemotaxisIDAliver developmentIEApositive regulation of osteoblast differentiationNASmitotic nuclear divisionNASblood coagulationTAScell chemotaxisIDAnegative regulation of hydrogen peroxide-mediated programmed cell deathIDAplatelet degranulationTAShyaluronan metabolic processIEAmyoblast proliferationIEAcatalytic activityIEAchemoattractant activityIDAgrowth factor activityNASidentical protein bindingIPIHepatocyte growth factor; Hepatopoietin-A; Scatter factor; SF; Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain; Precursor126902051280830128539481321034148234815167892154893341720571182487318266531826837183126618314321832556195765672062499021458362224214825289522531289866279894932729817840HGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHGFHepatocyte growth factor Hepatopoietin-A Scatter factor SF Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain Precursor172D - Genome Maintenancephotoreceptor inner segmentIEAinhibin A complexIDAneuronal cell bodyIEAextracellular regionTASinhibin-betaglycan-ActRII complexIDAphotoreceptor outer segmentIEAhemoglobin biosynthetic processIDAnegative regulation of B cell differentiationTAScell-cell signalingTASSMAD protein signal transductionIBAcell differentiationTASovarian follicle developmentNASnegative regulation of interferon-gamma biosynthetic processTASregulation of cell proliferationIDAregulation of MAPK cascadeIBAregulation of cell cycleIDAcell cycle arrestTAScell developmentIBApositive regulation of pathway-restricted SMAD protein phosphorylationIBAnegative regulation of follicle-stimulating hormone secretionNASpositive regulation of follicle-stimulating hormone secretionTASregulation of apoptotic processIBAnegative regulation of cell cycleTASnegative regulation of macrophage differentiationTASnervous system developmentNASnegative regulation of phosphorylationTASsignal transductionTASresponse to external stimulusTASskeletal system developmentTASerythrocyte differentiationNASmale gonad developmentIEAcell surface receptor signaling pathwayTAShormone activityTASreceptor bindingIPIgrowth factor activityTAStransforming growth factor beta receptor bindingIBAcytokine activityTASInhibin alpha chain; Precursor11098038147020391548933430167243754442375835588852409506758INHAINHAINHAINHAINHAINHAINHAINHAINHAINHAINHAINHAINHAINHAINHAINHAINHAINHAINHAINHAINHAINHAINHAINHAINHAINHAINHAINHAINHAINHAINHAINHAINHAInhibin alpha chain Precursor180C - Cellular Fate and Organizationcell junctionIEAplasma membraneTASmembraneISSjuxtaparanode region of axonISSpostsynaptic membraneIBApostsynaptic densityIBAnegative regulation of phosphatase activityIDAnucleotide phosphorylationTASsynaptic transmissionIBAreceptor clusteringIBAreceptor localization to synapseIBAsensory perception of painIEAnervous system developmentIBAionotropic glutamate receptor bindingIBAguanylate kinase activityTASkinase bindingIPIDisks large homolog 2; Channel-associated protein of synapse-110; Chapsyn-110; Postsynaptic density protein PSD-931470203915304517165548111663083517384233179740051911818919807924214066928755482DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2DLG2Disks large homolog 2 Channel-associated protein of synapse-110 Chapsyn-110 Postsynaptic density protein PSD-93244KLK6C - Cellular Fate and OrganizationmitochondrionIEAnuclear membraneIDAcytoplasmIDAendoplasmic reticulumIEAmicrotubule cytoskeletonIDAnucleolusIEAnucleoplasmIDAextracellular regionIDAextracellular spaceIDAintercellular bridgeIDAprotein autoprocessingNASpositive regulation of G-protein coupled receptor protein signaling pathwayIDAmyelinationNASresponse to woundingNASamyloid precursor protein metabolic processNAScentral nervous system developmentNAStissue regenerationNASprotein processingIBAregulation of neuron projection developmentIEAneuron deathIMPcollagen catabolic processNAShormone metabolic processNASregulation of cell differentiationNASserine-type endopeptidase activityIDAKallikrein-6; 3.4.21.-; Neurosin; Protease M; SP59; Serine protease 18; Serine protease 9; Zyme; Precursor106107191099785811018688110545741166819611983703120162111287820312928483147020391505782415207701154893341555775716321973168007391698722717417874889837890034509312124KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6KLK6Kallikrein-6 3.4.21.- Neurosin Protease M SP59 Serine protease 18 Serine protease 9 Zyme Precursor187SPINT2F - Protein FatecytoplasmIDAextracellular regionTASintegral component of membraneTASnegative regulation of endopeptidase activityIDAmovement of cell or subcellular componentTASendopeptidase inhibitor activityTASserine-type endopeptidase inhibitor activityIDAKunitz-type protease inhibitor 2; Hepatocyte growth factor activator inhibitor type 2; HAI-2; Placental bikunin; Precursor1470203915057824153401611548933419185281911529493468909434156SPIT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2SPINT2Kunitz-type protease inhibitor 2 Hepatocyte growth factor activator inhibitor type 2 HAI-2 Placental bikunin Precursor209FEZF2C - Cellular Fate and OrganizationnucleusIEAdentate gyrus developmentIEAnegative regulation of cell proliferationIEAnegative regulation of transcription from RNA polymerase II promoterIEAtranscription, DNA-templatedIEAdendrite developmentIEAcerebral cortex GABAergic interneuron migrationIEAaxonal fasciculationIEAaxon guidanceIEAforebrain anterior/posterior pattern specificationIEApositive regulation of neuron differentiationIEAlocomotory behaviorIEApositive regulation of transcription, DNA-templatedIEAcommitment of neuronal cell to specific neuron type in forebrainIEARNA polymerase II core promoter proximal region sequence-specific DNA bindingIEAmetal ion bindingIEAFez family zinc finger protein 2; Forebrain embryonic zinc finger-like protein 2; Zinc finger protein 312; Zinc finger protein Fez-like147020391548933421220648FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2FEZF2Fez family zinc finger protein 2 Forebrain embryonic zinc finger-like protein 2 Zinc finger protein 312 Zinc finger protein Fez-like170C - Cellular Fate and Organizationplasma membraneIEAanchored component of membraneIEANotch signaling pathwayIEAaxon guidanceTAScentral nervous system developmentTAScell adhesionTASContactin-6; Neural recognition molecule NB-3; hNB-3; Precursor15489334169599741969033220133774212206489486763CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6CNTN6Contactin-6 Neural recognition molecule NB-3 hNB-3 Precursor171C - Cellular Fate and OrganizationnucleoplasmTASnucleusIDAskeletal system developmentTASregulation of transcription from RNA polymerase II promoterIBAtranscription from RNA polymerase II promoterIBApositive regulation of transcription from RNA polymerase II promoterIEAnegative regulation of transcription from RNA polymerase II promoterIDApositive regulation of transcription, DNA-templatedIDAcell differentiationIBAtranscriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific bindingIDAtranscription factor activity, sequence-specific DNA bindingIDARNA polymerase II transcription factor activity, sequence-specific DNA bindingIBARNA polymerase II core promoter proximal region sequence-specific DNA bindingIDADNA bindingTASProtein C-ets-2108309531190996214702039154893341869197622509102421857228471452997781ETS2ETS2ETS2ETS2ETS2ETS2ETS2ETS2ETS2ETS2ETS2ETS2ETS2ETS2ETS2ETS2ETS2ETS2ETS2ETS2ETS2ETS2ETS2ETS2ETS2ETS2ETS2ETS2ETS2ETS2ETS2Protein C-ets-2190N - Not Matchedintegral component of membraneIEALow-density lipoprotein receptor-related protein 11; LRP-11; Precursor145744041470203915489334LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11LRP11Low-density lipoprotein receptor-related protein 11 LRP-11 Precursor456TP53D - Genome Maintenancenuclear chromatinIDAendoplasmic reticulumIEAreplication forkIBAnucleolusIDAnucleusIDAnuclear matrixIDAcytosolIDAmitochondrionIDAprotein complexIDAcytoplasmIDAmitochondrial matrixIEAPML bodyIDAnucleoplasmIDAchromatinIBAnegative regulation of cell growthIMPresponse to salt stressIEArRNA transcriptionIEApositive regulation of peptidyl-tyrosine phosphorylationISSneuron apoptotic processIEAcell differentiationTAScellular response to UVIBApositive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayTASchromatin assemblyIDAB cell lineage commitmentIEApositive regulation of protein oligomerizationIDApositive regulation of mitochondrial membrane permeabilityIEAresponse to gamma radiationIMPresponse to antibioticIEPprotein import into nucleus, translocationIEApositive regulation of thymocyte apoptotic processISSpositive regulation of intrinsic apoptotic signaling pathwayIMPmulticellular organismal developmentIMPcerebellum developmentIEAin utero embryonic developmentIEAcellular response to ionizing radiationIMPDNA strand renaturationIDAintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorIDAresponse to ischemiaIEAbase-excision repairTASnucleotide-excision repairIMPreplicative senescenceIMPnegative regulation of fibroblast proliferationIMPrelease of cytochrome c from mitochondriaIEApositive regulation of cell agingIEAdetermination of adult lifespanISSdouble-strand break repairIEAT cell proliferation involved in immune responseIEAembryonic organ developmentIEAviral processIEAentrainment of circadian clock by photoperiodISSregulation of mitochondrial membrane permeabilityTASnecroptotic processIEAcellular response to hypoxiaIEPregulation of apoptotic processIDAnegative regulation of helicase activityTAScellular response to drugIEPcellular response to DNA damage stimulusIDAmitotic cell cycle arrestIEApositive regulation of histone deacetylationIBAregulation of tissue remodelingIEAblood coagulationTASregulation of mitochondrial membrane permeability involved in apoptotic processIEAnegative regulation of DNA replicationIEAmitotic G1 DNA damage checkpointIMPER overload responseIDAtranscription from RNA polymerase II promoterIDAsomitogenesisIEAnegative regulation of neuroblast proliferationIEApositive regulation of cell cycle arrestIMPpositive regulation of neuron apoptotic processIBANotch signaling pathwayTASoligodendrocyte apoptotic processIDApositive regulation of cardiac muscle cell apoptotic processIEAtransforming growth factor beta receptor signaling pathwayIEAT cell lineage commitmentIEADNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorIMPDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestTAST cell differentiation in thymusIEADNA damage response, signal transduction by p53 class mediatorIDAcell agingIMPnegative regulation of transcription from RNA polymerase II promoterIDAintrinsic apoptotic signaling pathway by p53 class mediatorIMPpositive regulation of transcription, DNA-templatedIDAnegative regulation of reactive oxygen species metabolic processIEAnegative regulation of transcription, DNA-templatedIDApositive regulation of reactive oxygen species metabolic processIMPnegative regulation of cell proliferationISSgastrulationIEAresponse to X-rayIBAcell proliferationTASoxidative stress-induced premature senescenceIMPRas protein signal transductionIEPcircadian behaviorISSprotein localizationIDAmulticellular organism growthIEApositive regulation of transcription from RNA polymerase II promoterIDApositive regulation of release of cytochrome c from mitochondriaIDAregulation of fibroblast apoptotic processIEAmitochondrial DNA repairIEAcell cycle arrestIMPcellular response to glucose starvationIDAnegative regulation of macromitophagyIEAnegative regulation of transforming growth factor beta receptor signaling pathwayIEAnegative regulation of apoptotic processIDAregulation of transcription, DNA-templatedIDApositive regulation of apoptotic processIDAprotein tetramerizationTASapoptotic processTASintrinsic apoptotic signaling pathwayTASprotein complex assemblyIDAregulation of intrinsic apoptotic signaling pathway by p53 class mediatorIEAcellular protein localizationIDAtranscription factor activity, sequence-specific DNA bindingIDAtranscription regulatory region DNA bindingIDARNA polymerase II transcription factor activity, sequence-specific DNA bindingIDAchaperone bindingIPIprotease bindingIPIidentical protein bindingIPIp53 bindingIBARNA polymerase II transcription factor bindingIPIcore promoter sequence-specific DNA bindingISSprotein phosphatase 2A bindingIPIubiquitin protein ligase bindingIPIhistone acetyltransferase bindingIPIreceptor tyrosine kinase bindingIPIhistone deacetylase regulator activityIEAprotein heterodimerization activityIPIprotein kinase bindingIPIcopper ion bindingIDAprotein phosphatase bindingIPItranscriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingIDADNA bindingIMPRNA polymerase II core promoter sequence-specific DNA bindingIEAATP bindingIDAdamaged DNA bindingIBAtranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingIEAprotein N-terminus bindingIPIchromatin bindingIDAzinc ion bindingTASenzyme bindingIPItranscription factor bindingIPICellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p5310484981105493561055182610570149106067441064499610656795107227421088434710951572110078001102361311025664110585901112495511239457114472251148149011546806115519301155444811554766116725231170603011740489117801261192543012085209125074301270276612724314127502541281072412851404129444681303181132775113942251437144145342971459726146607941470203914702041150538791505388015109303151360351518677515340061154893341552593815651441570164115855171158661711613161116219768163115116322561163763381637762416402859164158811647440216477681662519616704422167273216793544168453831694291169599741699228170158381705009171081071710897117121812171707021722407417245430172549681731130217317671173499581737852174679531752533217591690177072341771954117805299179041271796787418022393182069651824918718453682184866818492341858500418650397186847318996393190584019152671933902194133301947399219509332195157281953613119556538196088611977611519787571983767019880522199933820041275200964472011823320124405201420402017309820228809203641302038513320660729206739902087072520959462212694602131793221411712156209219463512195263922214662225938522636462272644022864287229452892343117124051492290568829469353025664389493340069166396087768276377737777878469788741480134548023157802315981188198266092831662883369448402617863290386329158718514882592088296278829653887592688759299101296932140293729549419979945090194520429840937P53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53TP53Cellular tumor antigen p53 Antigen NY-CO-13 Phosphoprotein p53 Tumor suppressor p53169SH2B2C - Cellular Fate and Organizationstress fiberIEAcytoplasmIDAplasma membraneIDAactin filamentIEAruffleIEAcytosolTASinsulin receptor signaling pathwayISSactin cytoskeleton organizationIEAcytokine-mediated signaling pathwayIEAregulation of metabolic processIEAregulation of JAK-STAT cascadeIDAregulation of Ras protein signal transductionIEAantigen receptor-mediated signaling pathwayIEAnervous system developmentIEAintracellular signal transductionIDAsignal transductionTASbrown fat cell differentiationIEAblood coagulationTASB-1 B cell homeostasisIEAJAK pathway signal transduction adaptor activityIDASH3/SH2 adaptor activityIDAsignal transducer activityIEASH2B adapter protein 2; Adapter protein with pleckstrin homology and Src homology 2 domains; SH2 and PH domain-containing adapter protein APS103748811240001412853948153780311612941292337739989826SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B2SH2B adapter protein 2 Adapter protein with pleckstrin homology and Src homology 2 domains SH2 and PH domain-containing adapter protein APS165NTNG1N - Not Matchedanchored component of plasma membraneISSaxonogenesisISSNetrin-G1; Laminet-1; Precursor102310321297530914595443153401611548933415901489167104141797400521946559NTNG1NTNG1NTNG1NTNG1NTNG1NTNG1NTNG1NTNG1NTNG1NTNG1NTNG1NTNG1NTNG1NTNG1NTNG1NTNG1NTNG1NTNG1NTNG1NTNG1NTNG1NTNG1NTNG1NTNG1NTNG1NTNG1NTNG1Netrin-G1 Laminet-1 Precursor165LCN2A - Transport and Sensingextracellular regionISSextracellular spaceIDAcytosolIEAextracellular exosomeIDAcellular response to hydrogen peroxideIEAresponse to drugIEAresponse to herbicideIEAresponse to virusIEAtransmembrane transportTASextrinsic apoptotic signaling pathway in absence of ligandIEApositive regulation of gene expressionIEAcellular iron ion homeostasisTASprotein homotrimerizationIEAcellular response to lipopolysaccharideIEApositive regulation of cell projection organizationIEAinnate immune responseISScellular response to nutrient levelsIEAcellular response to interleukin-1IEAcellular response to tumor necrosis factorIEAsiderophore transportISSion transportIEAtransporter activityIEAiron ion bindingISSsmall molecule bindingIEANeutrophil gelatinase-associated lipocalin; NGAL; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; Lipocalin-2; Oncogene 24p3; Siderocalin LCN2; p25; Precursor1033941210684642124534121245341312817921470203915084671151640531548933416335952167400021915921819229297212694607683678783542380603299339356NGALLCN2LCN2LCN2LCN2LCN2LCN2LCN2LCN2LCN2LCN2LCN2LCN2LCN2LCN2LCN2LCN2LCN2LCN2LCN2LCN2Neutrophil gelatinase-associated lipocalin NGAL 25 kDa alpha-2-microglobulin-related subunit of MMP-9 Lipocalin-2 Oncogene 24p3 Siderocalin LCN2 p25 Precursor173SH3GLB2N - Not MatchedcytoplasmIDAnucleusIDAnucleoplasmIDAEndophilin-B2; SH3 domain-containing GRB2-like protein B211161816113479061516405315489334154988742126946022814378SHLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2SH3GLB2Endophilin-B2 SH3 domain-containing GRB2-like protein B2230MYCBP2 {ECO:0000312|HGNC:HGNC:23386}T - TranscriptionaxonIEAmembraneIDAmicrotubule cytoskeletonIEAnucleusIEAregulation of protein localizationIEAbranchiomotor neuron axon guidanceIEAregulation of transcription, DNA-templatedIEAregulation of cytoskeleton organizationIEAnegative regulation of protein catabolic processIEAcentral nervous system projection neuron axonogenesisIEAtranscription, DNA-templatedIEAubiquitin-protein transferase activityIEAligase activityIEAzinc ion bindingIEAE3 ubiquitin-protein ligase MYCBP2; 6.3.2.-; Myc-binding protein 2; Pam/highwire/rpm-1 protein; Protein associated with Myc1004848511042152121689541455989715057823154893341708198318308511186696481869197619369195193985811941333019690332200682312126946021406692242755699689053MYCB2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2MYCBP2E3 ubiquitin-protein ligase MYCBP2 6.3.2.- Myc-binding protein 2 Pam/highwire/rpm-1 protein Protein associated with Myc199APBA1F - Protein Fateprotein complexIEAperinuclear region of cytoplasmIEAGolgi apparatusIEAplasma membraneIEAnucleusIEAsynaptic vesicleTASregulation of gene expressionIEAgamma-aminobutyric acid secretionIEAsynaptic transmissionTASin utero embryonic developmentIEAintracellular protein transportTASglutamate secretionIEAnervous system developmentTASprotein complex assemblyTASmulticellular organism growthIEAlocomotory behaviorIEAaxon cargo transportTAScell adhesionTASbeta-amyloid bindingIEAphosphatidylinositol-4,5-bisphosphate bindingIEAAmyloid beta A4 precursor protein-binding family A member 1; Adapter protein X11alpha; Neuron-specific X11 protein; Neuronal Munc18-1-interacting protein 1; Mint-1151640531969033220531236237379712427556976783318887653932139393954809614075APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1APBA1Amyloid beta A4 precursor protein-binding family A member 1 Adapter protein X11alpha Neuron-specific X11 protein Neuronal Munc18-1-interacting protein 1 Mint-1176LAMC1C - Cellular Fate and Organizationextracellular matrixIDAlaminin-10 complexTASlaminin-1 complexNASextracellular regionTASlaminin-11 complexTASextracellular spaceNASextracellular exosomeIDAbasement membraneIDApositive regulation of epithelial cell proliferationTASprotein complex assemblyIDAextracellular matrix disassemblyIMPcell migrationIMPendoderm developmentTASextracellular matrix organizationTASaxon guidanceTAShemidesmosome assemblyIMPsubstrate adhesion-dependent cell spreadingIDAcell adhesionIDAglycosphingolipid bindingIEAextracellular matrix structural constituentIMPLaminin subunit gamma-1; Laminin B2 chain; Laminin-1 subunit gamma; Laminin-10 subunit gamma; Laminin-11 subunit gamma; Laminin-2 subunit gamma; Laminin-3 subunit gamma; Laminin-4 subunit gamma; Laminin-6 subunit gamma; Laminin-7 subunit gamma; Laminin-8 subunit gamma; Laminin-9 subunit gamma; S-laminin subunit gamma; S-LAM gamma; Precursor1275451916335952167104141695997418060431915921819858952126946021406692229059122427556932340373360804LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1LAMC1Laminin subunit gamma-1 Laminin B2 chain Laminin-1 subunit gamma Laminin-10 subunit gamma Laminin-11 subunit gamma Laminin-2 subunit gamma Laminin-3 subunit gamma Laminin-4 subunit gamma Laminin-6 subunit gamma Laminin-7 subunit gamma Laminin-8 subunit gamma Laminin-9 subunit gamma S-laminin subunit gamma S-LAM gamma Precursor302RASA1D - Genome MaintenanceintracellularIEAcytoplasmNASintrinsic component of the cytoplasmic side of the plasma membraneIBAruffleIEAcytosolTASvascular endothelial growth factor receptor signaling pathwayTASephrin receptor signaling pathwayTASregulation of RNA metabolic processNASmitotic cytokinesisISSregulation of cell shapeNASblood vessel morphogenesisIMPembryo developmentISSintracellular signal transductionNASnegative regulation of Ras protein signal transductionIBAsignal transductionIEAnegative regulation of neuron apoptotic processISSnegative regulation of cell adhesionIDAregulation of actin filament polymerizationIDAaxon guidanceTASvasculogenesisISSnegative regulation of cell-matrix adhesionIDAglycoprotein bindingIPIGTPase bindingIPIreceptor bindingIPIpotassium channel inhibitor activityNASGTPase activator activityIEARas GTPase-activating protein 1; GAP; GTPase-activating protein; RasGAP; Ras p21 protein activator; p120GAP11389730120913891375321146395291470203915372022154893341550403215592455157136731797400518024423212387821269460216642722222389522814378240389093201259813781182750888360177861889689552779219684RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1RASA1Ras GTPase-activating protein 1 GAP GTPase-activating protein RasGAP Ras p21 protein activator p120GAP276SH3GL2C - Cellular Fate and Organizationplasma membraneTASGolgi membraneTASclathrin-coated endocytic vesicle membraneTAScytosolTASextracellular exosomeIDAsignal transductionTASantigen processing and presentation of exogenous peptide antigen via MHC class IITASneurotrophin TRK receptor signaling pathwayTASepidermal growth factor receptor signaling pathwayTASaxon guidanceTASregulation of receptor internalizationIEApost-Golgi vesicle-mediated transportTASnegative regulation of epidermal growth factor receptor signaling pathwayTASmembrane organizationTASsynaptic vesicle endocytosisIEAcentral nervous system developmentTASlipid bindingIEAidentical protein bindingIPIEndophilin-A1; EEN-B1; Endophilin-1; SH3 domain protein 2A; SH3 domain-containing GRB2-like protein 21053137910542231147020391516405316763557173505721860246321269460232850279169142SH3G2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2SH3GL2Endophilin-A1 EEN-B1 Endophilin-1 SH3 domain protein 2A SH3 domain-containing GRB2-like protein 2438EP300D - Genome Maintenancetranscription factor complexIEAcytoplasmIDAhistone acetyltransferase complexIEAnucleoplasmIDAnucleusIDAresponse to estrogenIDAlung developmentIEAsomitogenesisIEAchromatin organizationTASregulation of transcription from RNA polymerase II promoter in response to hypoxiaTASN-terminal peptidyl-lysine acetylationIDApositive regulation of protein bindingIEAcellular response to heatTASheart developmentIEApositive regulation of sequence-specific DNA binding transcription factor activityIDANotch signaling pathwayTASpositive regulation of transcription from RNA polymerase II promoterIDAG2/M transition of mitotic cell cycleTASregulation of cell cycleTASorgan morphogenesisIEAviral processIEApositive regulation of type I interferon productionTASinternal protein amino acid acetylationIDAresponse to hypoxiaIDAregulation of transcription, DNA-templatedIDApositive regulation of transcription from RNA polymerase II promoter involved in unfolded protein responseISSregulation of androgen receptor signaling pathwayIDAprotein stabilizationISScellular response to hypoxiaTASapoptotic processIMPnegative regulation of transcription from RNA polymerase II promoterIDApositive regulation by host of viral transcriptionIDAtranscription, DNA-templatedIEAnervous system developmentTASinternal peptidyl-lysine acetylationIDAintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorIDAhistone H4 acetylationIMPskeletal muscle tissue developmentIEAinnate immune responseTAShistone H2B acetylationIDAcircadian rhythmISSregulation of tubulin deacetylationIDAmitotic cell cycleTASregulation of cellular response to heatTASRNA polymerase II activating transcription factor bindingIPItransferase activity, transferring acyl groupsIDAbeta-catenin bindingIPItranscription coactivator activityIDAnuclear hormone receptor bindingIPIcore promoter bindingIDAandrogen receptor bindingIPIprotein C-terminus bindingIPIRNA polymerase II core promoter sequence-specific DNA bindingIEADNA bindingIDAchromatin DNA bindingIEAlysine N-acetyltransferase activity, acting on acetyl phosphate as donorIDAchromatin bindingIMPzinc ion bindingIEAacetyltransferase activityIDApre-mRNA intronic bindingIEAactivating transcription factor bindingIPIhistone acetyltransferase activityIDAtranscription factor bindingIPIHistone acetyltransferase p300; p300 HAT; 2.3.1.48 {ECO:0000269|PubMed:23415232, ECO:0000269|PubMed:23934153, ECO:0000269|PubMed:8945521}; E1A-associated protein p3001054512110591208107001881072272810733570108239611082499811073989110739901108047611349124114308251146383411481323115186991155982111564735115811641158137211701890117447331186491011959990119974991240203712446687125279171258684012718889127502541277811412837748129299311460544714645221147160051475205315004546150753191518677515297880155098081563219315706485157313521589067716478997165746621661710216762839168645821706515317226766178729501827302118669648186950001872235318809579189958421921739119413330196088611968022419690332200812282126946021406692222238952246433123145062234152322391128923934153239994302417753524275569244135322481939725219498752324578701798684459891752889455219528808959069698629599887100EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300EP300Histone acetyltransferase p300 p300 HAT 2.3.1.48 {ECO:0000269|PubMed:23415232, ECO:0000269|PubMed:23934153, ECO:0000269|PubMed:8945521} E1A-associated protein p300185KLK8F - Protein FatecytoplasmIDAextracellular spaceISScell deathISSsynapse organizationIEAnegative regulation of axon regenerationISSregulation of synapse organizationISSneuron projection morphogenesisISSresponse to woundingISSmemoryISSkeratinocyte proliferationISSnegative regulation of myelinationISSserine-type endopeptidase activityIDAKallikrein-8; hK8; 3.4.21.118; Neuropsin; NP; Ovasin; Serine protease 19; Serine protease TADG-14; Tumor-associated differentially expressed gene 14 protein; Precursor1010299010485494110545741130932611522960121477141278258112975309150578241528233115489334163372001748784717761692191944799714609KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8KLK8Kallikrein-8 hK8 3.4.21.118 Neuropsin NP Ovasin Serine protease 19 Serine protease TADG-14 Tumor-associated differentially expressed gene 14 protein Precursor186EGR1C - Cellular Fate and OrganizationcytoplasmISSnucleusISSnucleoplasmIDAtranscription from RNA polymerase II promoterIDAoligodendrocyte differentiationIEAresponse to ethanolIEAcytokine-mediated signaling pathwayTASglomerular mesangial cell proliferationISSlong-term synaptic potentiationIEAcellular response to gamma radiationIEAresponse to cocaineIEAskeletal muscle cell differentiationIBAcellular response to follicle-stimulating hormone stimulusIEAcellular response to gonadotropin stimulusIBApositive regulation of glomerular metanephric mesangial cell proliferationISSpositive regulation of neuron apoptotic processIEAtype I interferon signaling pathwayTASpositive regulation of transcription from RNA polymerase II promoterIDAresponse to electrical stimulusIEAregulation of long-term neuronal synaptic plasticityIBAlearning or memoryIEAresponse to nutrient levelsIEAregulation of protein sumoylationIDAnegative regulation of canonical Wnt signaling pathwayIEAresponse to carbon monoxideIEAinterleukin-1-mediated signaling pathwayIMPcellular response to antibioticIEAcellular response to insulin stimulusIEAnegative regulation of apoptotic processIBAcellular response to hyperoxiaIEAcellular response to hypoxiaIEAnegative regulation of transcription from RNA polymerase II promoterIEABMP signaling pathwayIEAcellular response to drugIEAcellular response to isoquinoline alkaloidIEAresponse to glucoseIEAresponse to amphetamineIEAT cell differentiationIEAcellular response to growth factor stimulusIEAcellular response to heparinISScellular response to steroid hormone stimulusIEAcellular response to mycophenolic acidISScircadian rhythmIEAresponse to norepinephrineIEApositive regulation of transcription, DNA-templatedIDAcellular response to mechanical stimulusIEAcellular response to cAMPIBAhistone acetyltransferase bindingIPIsequence-specific DNA bindingIDAtranscription regulatory region sequence-specific DNA bindingIDAtranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingIEAdouble-stranded DNA bindingIEAtranscription factor activity, sequence-specific DNA bindingIDARNA polymerase II core promoter sequence-specific DNA bindingIEADNA bindingIDAmetal ion bindingIEAEarly growth response protein 1; EGR-1; AT225; Nerve growth factor-induced protein A; NGFI-A; Transcription factor ETR103; Transcription factor Zif268; Zinc finger protein 225; Zinc finger protein Krox-24154893341569051196903322012194921103812377485EGR1EGR1EGR1EGR1EGR1EGR1EGR1EGR1EGR1EGR1EGR1EGR1EGR1EGR1EGR1EGR1EGR1EGR1EGR1EGR1EGR1EGR1EGR1EGR1EGR1EGR1EGR1EGR1EGR1EGR1EGR1Early growth response protein 1 EGR-1 AT225 Nerve growth factor-induced protein A NGFI-A Transcription factor ETR103 Transcription factor Zif268 Zinc finger protein 225 Zinc finger protein Krox-24166C - Cellular Fate and Organizationextracellular matrixIDAperinuclear region of cytoplasmISSlaminin-10 complexIDAlaminin-8 complexIDAlaminin-1 complexIDAlaminin-2 complexIDAextracellular regionTASextracellular spaceIDAextracellular exosomeIDAbasement membraneIDApositive regulation of epithelial cell proliferationTASpositive regulation of cell migrationIDAembryo implantationIEAneuronal-glial interaction involved in cerebral cortex radial glia guided migrationIMPendodermal cell differentiationIEPneuron projection developmentIDAnegative regulation of cell adhesionIEAextracellular matrix disassemblyTASaxon guidanceTASextracellular matrix organizationTASodontogenesisIDAsubstrate adhesion-dependent cell spreadingIDAcell adhesionTASglycosphingolipid bindingIEAstructural molecule activityNASextracellular matrix structural constituentIDALaminin subunit beta-1; Laminin B1 chain; Laminin-1 subunit beta; Laminin-10 subunit beta; Laminin-12 subunit beta; Laminin-2 subunit beta; Laminin-6 subunit beta; Laminin-8 subunit beta; Precursor12690205154893341633595219159218197558921269460234727592427556936110773661559LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1LAMB1Laminin subunit beta-1 Laminin B1 chain Laminin-1 subunit beta Laminin-10 subunit beta Laminin-12 subunit beta Laminin-2 subunit beta Laminin-6 subunit beta Laminin-8 subunit beta Precursor235OPCMLC - Cellular Fate and Organizationneuron projectionIBAplasma membraneTAScell surfaceIBAcell-cell junctionIBAneuronal cell bodyIBAanchored component of membraneIEAextracellular exosomeIDAsingle organismal cell-cell adhesionIBAneuron recognitionTASregulation of neurogenesisIBAcell adhesionTASOpioid-binding protein/cell adhesion molecule; OBCAM; OPCML; Opioid-binding cell adhesion molecule; IgLON family member 1; Precursor12819783147020391548933416554811179740057721093OPCMOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOPCMLOpioid-binding protein/cell adhesion molecule OBCAM OPCML Opioid-binding cell adhesion molecule IgLON family member 1 Precursor479APBB1D - Genome MaintenancecytoplasmIDAplasma membraneIDAnuclear speckIEAsynapseIDAnucleusIDAlamellipodiumIDAgrowth coneIDAregulation of transcription, DNA-templatedISSnegative regulation of cell growthISSpositive regulation of apoptotic processIDAapoptotic processIEAaxonogenesisNASpositive regulation of DNA repairIEAcellular response to DNA damage stimulusIDAtranscription, DNA-templatedIEAdouble-strand break repairIEAsignal transductionNASnegative regulation of neuron differentiationIEAhistone H4 acetylationISSextracellular matrix organizationIEAaxon guidanceIEAvisual learningIEApositive regulation of transcription from RNA polymerase II promoterIEAcell cycle arrestISSpositive regulation of transcription, DNA-templatedIDAneuron migrationIEAnegative regulation of thymidylate synthase biosynthetic processISShistone bindingIPIbeta-amyloid bindingIPIchromatin bindingIDAproline-rich region bindingIPItranscription factor bindingISSAmyloid beta A4 precursor protein-binding family B member 1; Protein 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 beta A4 precursor protein-binding family B member 1 Protein Fe65165F - Protein FatenucleusIEAcytosolIDAprotein ubiquitination involved in ubiquitin-dependent protein catabolic processIMPpositive regulation of canonical Wnt signaling pathwayIMPWnt signaling pathwayIEAprotein K48-linked ubiquitinationIMPprotein autoubiquitinationIDAubiquitin-protein transferase activityIDApoly-ADP-D-ribose bindingIDAligase activityIEAzinc ion bindingIEAE3 ubiquitin-protein ligase RNF146; 6.3.2.-; Dactylidin; Iduna; RING finger protein 1461123016614574404147020391548933415813938183266231951727119690183214455722147885921602803217999112182515122267412RN146RNF146RNF146RNF146RNF146RNF146RNF146RNF146RNF146RNF146RNF146RNF146RNF146RNF146RNF146RNF146RNF146E3 ubiquitin-protein ligase RNF146 6.3.2.- Dactylidin Iduna RING finger protein 146178RUNX2C - Cellular Fate and Organizationtranscription factor complexIEAcytoplasmIEAnuclear chromatinISSnucleoplasmIDAcellular response to BMP stimulusISSgene expressionTASpositive regulation of cell proliferationIEAtranscription initiation from RNA polymerase II promoterTASnegative regulation of smoothened signaling pathwayIEAembryonic cranial skeleton morphogenesisIEAchondrocyte developmentIEAodontogenesis of dentin-containing toothIEApositive regulation of chondrocyte differentiationIEAcell maturationIEApositive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulusISSosteoblast fate commitmentIEABMP signaling pathwayISSosteoblast differentiationIEPpositive regulation of osteoblast differentiationIEAstem cell differentiationIEAendochondral ossificationIEAT cell differentiationIEAosteoblast developmentIEAossificationTASregulation of fibroblast growth factor receptor signaling pathwayIEAregulation of odontogenesis of dentin-containing toothIEAembryonic forelimb morphogenesisIEApositive regulation of transcription, DNA-templatedIDAnegative regulation of transcription, DNA-templatedIDAtranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingIEAtranscription factor activity, sequence-specific DNA bindingNASchromatin bindingIEARNA polymerase II core promoter proximal region sequence-specific DNA bindingIEAATP bindingIEARNA polymerase II core promoter sequence-specific DNA bindingIEARunt-related transcription factor 2; Acute myeloid leukemia 3 protein; Core-binding factor subunit alpha-1; CBF-alpha-1; Oncogene AML-3; Osteoblast-specific transcription factor 2; OSF-2; Polyomavirus enhancer-binding protein 2 alpha A subunit; PEA2-alpha A; PEBP2-alpha A; SL3-3 enhancer factor 1 alpha A subunit; SL3/AKV core-binding factor alpha A subunit10521292105456121068918310980549118577361196554612081718121453061219691612424590145744041627035316407259182203361974417120082269206486312329007491827659207800923377194349469651525RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2RUNX2Runt-related transcription factor 2 Acute myeloid leukemia 3 protein Core-binding factor subunit alpha-1 CBF-alpha-1 Oncogene AML-3 Osteoblast-specific transcription factor 2 OSF-2 Polyomavirus enhancer-binding protein 2 alpha A subunit PEA2-alpha A PEBP2-alpha A SL3-3 enhancer factor 1 alpha A subunit SL3/AKV core-binding factor alpha A subunit165MED6T - TranscriptionmembraneIDAmediator complexIMPnucleoplasmIDAnucleusTASgene expressionTAStranscription initiation from RNA polymerase II promoterTASregulation of transcription from RNA polymerase II promoterTASpositive regulation of transcription from RNA polymerase II promoterIDARNA polymerase II transcription cofactor activityIEAtranscription coactivator activityIDAtranscription factor bindingIPIMediator of RNA polymerase II transcription subunit 6; Activator-recruited cofactor 33 kDa component; ARC33; Mediator complex subunit 6; hMed6; Renal carcinoma antigen NY-REN-281002488310235267105084791099308211867769125081211470203915175163154893341598996716574658165956641700077919608861212694609734358MED6MED6MED6MED6MED6MED6MED6MED6MED6MED6MED6MED6MED6MED6MED6MED6MED6MED6MED6MED6MED6MED6MED6Mediator of RNA polymerase II transcription subunit 6 Activator-recruited cofactor 33 kDa component ARC33 Mediator complex subunit 6 hMed6 Renal carcinoma antigen NY-REN-28221PHF20L1N - Not Matchedzinc ion bindingIEAPHD finger protein 20-like protein 1108100931470203915489334164215711960886124275569P20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHF20L1PHD finger protein 20-like protein 1189N - Not Matchedcell junctionIEApostsynaptic membraneIEApostsynaptic densityISSSH2 domain-containing protein 514702039167104141941333025331951SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2D5SH2 domain-containing protein 5165LAMC2C - Cellular Fate and Organizationperinuclear region of cytoplasmIEAlaminin-5 complexIEAmembraneIEAlaminin-2 complexIEAextracellular regionTAScell cortexIEAextracellular spaceIEAextracellular matrix disassemblyTASepidermis developmentTASextracellular matrix organizationTAScell junction assemblyTAShemidesmosome assemblyTAScell adhesionIEAheparin bindingIEALaminin subunit gamma-2; Cell-scattering factor 140 kDa subunit; CSF 140 kDa subunit; Epiligrin subunit gamma; Kalinin subunit gamma; Kalinin/nicein/epiligrin 100 kDa subunit; Ladsin 140 kDa subunit; Laminin B2t chain; Laminin-5 subunit gamma; Large adhesive scatter factor 140 kDa subunit; Nicein subunit gamma; Precursor1383240154893341671041421269460826562483069888786121LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2LAMC2Laminin subunit gamma-2 Cell-scattering factor 140 kDa subunit CSF 140 kDa subunit Epiligrin subunit gamma Kalinin subunit gamma Kalinin/nicein/epiligrin 100 kDa subunit Ladsin 140 kDa subunit Laminin B2t chain Laminin-5 subunit gamma Large adhesive scatter factor 140 kDa subunit Nicein subunit gamma Precursor186HIST1H4AD - Genome Maintenanceprotein complexIDAmembraneIDAextracellular regionTASnucleusIDAnucleoplasmTASnuclear chromosomeIDAnucleosomeTASextracellular exosomeIDAgene expressionTAShistone H4-K20 demethylationTASchromatin organizationTASnucleosome assemblyTASDNA replication-dependent nucleosome assemblyIDADNA replication-independent nucleosome assemblyIDACENP-A containing nucleosome assemblyTASDNA methylation on cytosineTASnegative regulation of megakaryocyte differentiationIDAtelomere maintenanceTASchromatin silencing at rDNATASnegative regulation of gene expression, epigeneticTASregulation of gene expression, epigeneticTASmitotic cell cycleTASpoly(A) RNA bindingIDAhistone demethylase activity (H4-K20 specific)TASDNA bindingTASHistone H41138744211448779120866181240896612414651145744041457844915345777154893341552796315592455159515141596484616567635166781101695997417081983179678821866964819168251960886119690332198187142006823121269460214066922172482921925322242755692474456303571733401826314274762621876647358988030903162091193999439656H4HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4Histone H4169LAMB3C - Cellular Fate and Organizationlaminin-5 complexIEAextracellular regionTASextracellular matrix disassemblyTASepidermis developmentTASbrown fat cell differentiationIEAextracellular matrix organizationTAScell junction assemblyTAShemidesmosome assemblyTASendodermal cell differentiationIEPcell adhesionIEAstructural molecule activityNASLaminin subunit beta-3; Epiligrin subunit bata; Kalinin B1 chain; Kalinin subunit beta; Laminin B1k chain; Laminin-5 subunit beta; Nicein subunit beta; Precursor1129626915489334167104141695997417476356192759362126946075125587550237777491885300369767254LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3LAMB3Laminin subunit beta-3 Epiligrin subunit bata Kalinin B1 chain Kalinin subunit beta Laminin B1k chain Laminin-5 subunit beta Nicein subunit beta Precursor173CELSR3C - Cellular Fate and Organizationplasma membraneIEAintegral component of membraneTASregulation of protein localizationIEAcilium assemblyIEAaxonal fasciculationIEAG-protein coupled receptor signaling pathwayTASneuron migrationIEAhomophilic cell adhesion via plasma membrane adhesion moleculesIEAG-protein coupled receptor activityTAScalcium ion bindingIEACadherin EGF LAG seven-pass G-type receptor 3; Cadherin family member 11; Epidermal growth factor-like protein 1; EGF-like protein 1; Flamingo homolog 1; hFmi1; Multiple epidermal growth factor-like domains protein 2; Multiple EGF-like domains protein 2; Precursor1071672616641997186696489693030CELR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3CELSR3Cadherin EGF LAG seven-pass G-type receptor 3 Cadherin family member 11 Epidermal growth factor-like protein 1 EGF-like protein 1 Flamingo homolog 1 hFmi1 Multiple epidermal growth factor-like domains protein 2 Multiple EGF-like domains protein 2 Precursor210CELSR1C - Cellular Fate and Organizationplasma membraneIDAintegral component of plasma membraneTASnucleoplasmIDAintegral component of membraneTASestablishment of planar polarityISSlateral sprouting involved in lung morphogenesisIEAinner ear morphogenesisIEAprotein localization involved in establishment of planar polarityIEAplanar cell polarity pathway involved in neural tube closureIEAneural tube closureISSapical protein localizationIEARho protein signal transductionIEAcentral nervous system developmentNASanterior/posterior pattern specificationIEAestablishment of planar polarity of embryonic epitheliumIEAG-protein coupled receptor signaling pathwayNASplanar dichotomous subdivision of terminal units involved in lung branching morphogenesisIEAregulation of actin cytoskeleton organizationIEAorthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesisIEAwound healingIEAlocomotory behaviorIEAestablishment of body hair planar orientationIEAneuron migrationIEAhair follicle developmentIEAhomophilic cell adhesion via plasma membrane adhesion moleculesIEAG-protein coupled receptor activityNAScalcium ion bindingIEAprotein dimerization activityNAStransmembrane signaling receptor activityNASCadherin EGF LAG seven-pass G-type receptor 1; Cadherin family member 9; Flamingo homolog 2; hFmi2; Precursor1059120810716726154893341866964822095531CELR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1CELSR1Cadherin EGF LAG seven-pass G-type receptor 1 Cadherin family member 9 Flamingo homolog 2 hFmi2 Precursor181MATKC - Cellular Fate and Organizationextrinsic component of cytoplasmic side of plasma membraneIBAcytosolTASpositive regulation of cell proliferationTAScell migrationIBAcell proliferationTASinnate immune responseIBAregulation of cell proliferationIBAmesoderm developmentTASprotein phosphorylationTASpeptidyl-tyrosine autophosphorylationIBAtransmembrane receptor protein tyrosine kinase signaling pathwayIBAmorphogenesis of an epitheliumIBAcell differentiationIBAreceptor bindingIBAprotein tyrosine kinase activityTASATP bindingIEAnon-membrane spanning protein tyrosine kinase activityIBAMegakaryocyte-associated tyrosine-protein kinase; 2.7.10.2; CSK homologous kinase; CHK; Hematopoietic consensus tyrosine-lacking kinase; Protein kinase HYL; Tyrosine-protein kinase CTK1470203915057824154893341612941217344846179740051866964818691976193691951941333019690332753024979366648134117828856390382109171348MATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMATKMegakaryocyte-associated tyrosine-protein kinase 2.7.10.2 CSK homologous kinase CHK Hematopoietic consensus tyrosine-lacking kinase Protein kinase HYL Tyrosine-protein kinase CTK171NEURL1C - Cellular Fate and Organizationperinuclear region of cytoplasmIEAcell junctionIEAplasma membraneIDAdendritic spineISSpostsynaptic membraneIEApostsynaptic densityISSperikaryonISSapical dendriteISSnegative regulation of Notch signaling pathwayIDApositive regulation of synapse maturationISSpositive regulation of apoptotic processIDAnegative regulation of cell proliferationIDAprotein monoubiquitinationISSsperm axoneme assemblyIEApositive regulation of epidermal growth factor-activated receptor activityIEApositive regulation of filopodium assemblyISSsperm motilityIEAnervous system developmentTAScellular response to amino acid stimulusISSlactationIEANotch signaling pathwayIEApositive regulation of dendritic spine developmentISSpositive regulation of long-term neuronal synaptic plasticityISSubiquitin-protein transferase activityISSligase activityIEAzinc ion bindingIEAtranslation factor activity, non-nucleic acid bindingISSE3 ubiquitin-protein ligase NEURL1; 6.3.2.-; Neuralized-like protein 1A; h-neu; h-neuralized 1; RING finger protein 67115859281516405415489334208470829519875NEUL1NEURL1NEURL1NEURL1NEURL1NEURL1NEURL1NEURL1NEURL1NEURL1NEURL1NEURL1NEURL1NEURL1NEURL1NEURL1NEURL1NEURL1NEURL1NEURL1NEURL1NEURL1NEURL1NEURL1NEURL1NEURL1NEURL1NEURL1NEURL1NEURL1NEURL1NEURL1NEURL1NEURL1NEURL1NEURL1NEURL1NEURL1NEURL1E3 ubiquitin-protein ligase NEURL1 6.3.2.- Neuralized-like protein 1A h-neu h-neuralized 1 RING finger protein 67165D - Genome Maintenanceplasma membraneIDAcell surfaceISSlamellipodium membraneIEAbasal part of cellIEAapical part of cellIEAruffle membraneNASextracellular spaceIDAlamellipodiumIDAcytoplasmIEAinvadopodium membraneIDAintegral component of membraneNASfocal adhesionIDAregulation of collagen catabolic processIDAmelanocyte proliferationISSnegative regulation of cell proliferation involved in contact inhibitionISSregulation of fibrinolysisICangiogenesisIEAnegative regulation of extracellular matrix organizationIDApositive regulation of cell cycle arrestISSnegative regulation of extracellular matrix disassemblyIDAmitotic cell cycle arrestISSendothelial cell migrationIDApositive regulation of execution phase of apoptosisISSproteolysis involved in cellular protein catabolic processIDAproteolysisIDAcell adhesionIEAmelanocyte apoptotic processISSintegrin bindingIPIserine-type endopeptidase activityIDAendopeptidase activityIDAprotein dimerization activityNASserine-type peptidase activityIDApeptidase activityIDAprotease bindingIPIdipeptidyl-peptidase activityIDAmetalloendopeptidase activityTASprotein homodimerization activityIDAProlyl endopeptidase FAP {ECO:0000305}; 3.4.21.26 {ECO:0000269|PubMed:16223769}; 170 kDa melanoma membrane-bound gelatinase {ECO:0000303|PubMed:2172980, ECO:0000303|PubMed:9065413}; Dipeptidyl peptidase FAP {ECO:0000305}; 3.4.14.5 {ECO:0000269|PubMed:10347120}; Fibroblast activation protein alpha {ECO:0000303|PubMed:7911242}; FAPalpha {ECO:0000250|UniProtKB:P97321}; Gelatine degradation protease FAP {ECO:0000305}; 3.4.21.- {ECO:0000269|PubMed:9065413}; Integral membrane serine protease {ECO:0000303|PubMed:9247085}; Post-proline cleaving enzyme {ECO:0000305}; Serine integral membrane protease {ECO:0000303|PubMed:9247085}; SIMP {ECO:0000303|PubMed:9247085}; Surface-expressed protease {ECO:0000303|PubMed:2172980}; Seprase {ECO:0000303|PubMed:7923219}; Antiplasmin-cleaving enzyme FAP, soluble form {ECO:0000303|PubMed:14751930}; APCE {ECO:0000303|PubMed:14751930}; 3.4.14.5 {ECO:0000269|PubMed:14751930, ECO:0000269|PubMed:16223769}; 3.4.21.- {ECO:0000269|PubMed:14751930, ECO:0000269|PubMed:16223769}; 3.4.21.26 {ECO:0000269|PubMed:14751930, ECO:0000269|PubMed:16223769}103471201045517110593948106447131237646614751930154893341580930615815621161756011622376916335952164102481648071816651416171056461738107318095711182624972070760421288888213148172172980243717212471728875195847911242792321990654139247085SEPRFAPFAPFAPFAPFAPFAPFAPFAPFAPFAPFAPFAPFAPFAPFAPFAPFAPFAPFAPFAPFAPFAPFAPFAPFAPFAPFAPFAPFAPFAPFAPFAPFAPFAPProlyl endopeptidase FAP {ECO:0000305} 3.4.21.26 {ECO:0000269|PubMed:16223769} 170 kDa melanoma membrane-bound gelatinase {ECO:0000303|PubMed:2172980, ECO:0000303|PubMed:9065413} Dipeptidyl peptidase FAP {ECO:0000305} 3.4.14.5 {ECO:0000269|PubMed:10347120} Fibroblast activation protein alpha {ECO:0000303|PubMed:7911242} FAPalpha {ECO:0000250|UniProtKB:P97321} Gelatine degradation protease FAP {ECO:0000305} 3.4.21.- {ECO:0000269|PubMed:9065413} Integral membrane serine protease {ECO:0000303|PubMed:9247085} Post-proline cleaving enzyme {ECO:0000305} Serine integral membrane protease {ECO:0000303|PubMed:9247085} SIMP {ECO:0000303|PubMed:9247085} Surface-expressed protease {ECO:0000303|PubMed:2172980} Seprase {ECO:0000303|PubMed:7923219} Antiplasmin-cleaving enzyme FAP, soluble form {ECO:0000303|PubMed:14751930} APCE {ECO:0000303|PubMed:14751930} 3.4.14.5 {ECO:0000269|PubMed:14751930, ECO:0000269|PubMed:16223769} 3.4.21.- {ECO:0000269|PubMed:14751930, ECO:0000269|PubMed:16223769} 3.4.21.26 {ECO:0000269|PubMed:14751930, ECO:0000269|PubMed:16223769}297MYCD - Genome Maintenanceprotein complexIDAnucleolusIDAnucleoplasmIDAnucleusIDAcytosolTASregulation of gene expressionIDAgene expressionTASbranching involved in ureteric bud morphogenesisISSchromosome organizationIDApositive regulation of cell proliferationIDAtranscription initiation from RNA polymerase II promoterTASpositive regulation of DNA biosynthetic processIMPpositive regulation of response to DNA damage stimulusIDAnegative regulation of fibroblast proliferationIDApositive regulation of fibroblast proliferationIDAnegative regulation of stress-activated MAPK cascadeISScellular iron ion homeostasisIDAcellular response to UVIEPnegative regulation of monocyte differentiationIMPNotch signaling pathwayTASMAPK cascadeIMPpositive regulation of transcription from RNA polymerase II promoterIMPtransforming growth factor beta receptor signaling pathwayTAScell cycle arrestIDAchromatin remodelingIDAnegative regulation of cell divisionIDAcanonical Wnt signaling pathwayIDAresponse to gamma radiationIDApositive regulation of metanephric cap mesenchymal cell proliferationISSpositive regulation of epithelial cell proliferationIDAnegative regulation of apoptotic processISSresponse to drugIEPpositive regulation of mesenchymal cell proliferationISSnegative regulation of transcription from RNA polymerase II promoterIDAresponse to growth factorTASfibroblast apoptotic processTAScellular response to drugIDAcellular response to DNA damage stimulusIDAtranscription, DNA-templatedTASoxygen transportNASpositive regulation of cysteine-type endopeptidase activity involved in apoptotic processIDAenergy reserve metabolic processNASregulation of telomere maintenanceIMPpositive regulation of transcription, DNA-templatedIDAtranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingIDAtranscription factor activity, sequence-specific DNA bindingIDArepressing transcription factor bindingIPIE-box bindingIDARNA polymerase II core promoter proximal region sequence-specific DNA bindingIDAprotein complex bindingIDADNA bindingISStranscription factor bindingIPIMyc proto-oncogene protein; Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p641470203915103331154893341567432515723054159719616126174164215711708198317308053173118831755839717873522180354081866964819413330196088611996630020068231205511722071352621406692216699822307329354059162986326304538630472963211646414718641912265472096714223764255582204248386367844434693157429680483MYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMYCMyc proto-oncogene protein Class E basic helix-loop-helix protein 39 bHLHe39 Proto-oncogene c-Myc Transcription factor p64178SOCS7C - Cellular Fate and OrganizationcytoplasmIBAplasma membraneIEAnucleolusIDAnucleusIDAintracellular membrane-bounded organelleIDAinsulin receptor signaling pathwayIEAintracellular signal transductionIEAprotein ubiquitinationIEAcytokine-mediated signaling pathwayIBAfat cell differentiationIEAnegative regulation of protein kinase activityIBAnegative regulation of JAK-STAT cascadeIBAregulation of growthIEASH3 domain bindingNASprotein kinase inhibitor activityIBASuppressor of cytokine signaling 7; SOCS-7; Nck, Ash and phospholipase C gamma-binding protein; Nck-associated protein 4; NAP-4109691791524277815489334156774741612746016625196178039079344857SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7SOCS7Suppressor of cytokine signaling 7 SOCS-7 Nck, Ash and phospholipase C gamma-binding protein Nck-associated protein 4 NAP-4176PCDH7C - Cellular Fate and Organizationplasma membraneTASintegral component of plasma membraneTAShomophilic cell adhesion via plasma membrane adhesion moleculesIEAcalcium ion bindingIEAProtocadherin-7; Brain-heart protocadherin; BH-Pcdh; Precursor158156211866964819413330200682319615233PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7PCDH7Protocadherin-7 Brain-heart protocadherin BH-Pcdh Precursor165C - Cellular Fate and Organizationlipopolysaccharide receptor complexIDAperinuclear region of cytoplasmIDAcytoplasmIDAplasma membraneIDAintegral component of plasma membraneIDAendosome membraneTASexternal side of plasma membraneIDApositive regulation of interleukin-6 productionIDAnegative regulation of interleukin-6 productionISSpositive regulation of JNK cascadeIEAI-kappaB kinase/NF-kappaB signalingTASpositive regulation of interleukin-8 productionIDApositive regulation of MHC class II biosynthetic processIEAMyD88-independent toll-like receptor signaling pathwayTASMyD88-dependent toll-like receptor signaling pathwayTASpositive regulation of platelet activationISSresponse to lipopolysaccharideICdetection of lipopolysaccharideIDAnegative regulation of ERK1 and ERK2 cascadeISSpositive regulation of ERK1 and ERK2 cascadeIEAinterferon-gamma productionIEAnegative regulation of interferon-gamma productionISSlipopolysaccharide-mediated signaling pathwayIGIdefense response to bacteriumTASpositive regulation of interferon-gamma productionISSpositive regulation of interferon-beta productionISSB cell proliferation involved in immune responseIEAtoll-like receptor TLR6:TLR2 signaling pathwayTASpositive regulation of tumor necrosis factor productionISStoll-like receptor TLR1:TLR2 signaling pathwayTASpositive regulation of interferon-alpha productionISStoll-like receptor 2 signaling pathwayTASpositive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathwayIEApositive regulation of tumor necrosis factor biosynthetic processIDApositive regulation of interleukin-8 biosynthetic processIDAnegative regulation of tumor necrosis factor productionISSpositive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathwayIEApositive regulation of chemokine productionIDAtoll-like receptor signaling pathwayTASpositive regulation of interferon-beta biosynthetic processIEApositive regulation of interleukin-12 biosynthetic processIDAmacrophage activationIMPinnate immune responseTASintestinal epithelial structure maintenanceISSregulation of cytokine secretionIEATRIF-dependent toll-like receptor signaling pathwayTASdetection of fungusNASpositive regulation of NF-kappaB import into nucleusIDAtoll-like receptor 4 signaling pathwayTASpositive regulation of interleukin-10 productionISSpositive regulation of B cell proliferationIEApositive regulation of interleukin-1 productionISSpositive regulation of interleukin-12 productionISST-helper 1 type immune responseNASnitric oxide production involved in inflammatory responseIEApositive regulation of nitric oxide biosynthetic processIEAactivation of MAPK activityISSimmune responseTASpositive regulation of NF-kappaB transcription factor activityIDApositive regulation of transcription from RNA polymerase II promoterISStoll-like receptor 3 signaling pathwayTASnegative regulation of interleukin-23 productionISSI-kappaB phosphorylationIDAnegative regulation of osteoclast differentiationNASnegative regulation of interleukin-17 productionISSdefense response to Gram-negative bacteriumICcellular response to lipoteichoic acidIEAcellular response to lipopolysaccharideISSpositive regulation of inflammatory responseICpositive regulation of macrophage cytokine productionIEApositive regulation of nitric-oxide synthase biosynthetic processISScellular response to mechanical stimulusIEPlipopolysaccharide bindingNASlipopolysaccharide receptor activityIDAreceptor activityTAStransmembrane signaling receptor activityNASToll-like receptor 4; hToll; CD284; Precursor10835634110815181110451811514453117060421470203915164053153401611535610115489334158294981747872917803912188104251925248019924287200375842071119220865800216028442236351992377599435236TLR4TLR4TLR4TLR4TLR4TLR4TLR4TLR4TLR4TLR4TLR4TLR4TLR4TLR4TLR4TLR4TLR4TLR4TLR4TLR4TLR4TLR4TLR4Toll-like receptor 4 hToll CD284 Precursor165USF1C - Cellular Fate and Organizationtranscription factor complexIDAnucleusIDAnucleoplasmIDAresponse to hypoxiaIMPcellular response to insulin stimulusIDAlate viral transcriptionIDAregulation of transcription from RNA polymerase II promoterTAStranscription from RNA polymerase II promoterIDAlipid homeostasisISSnegative regulation of fibrinolysisICglucose homeostasisTAScarbon catabolite regulation of transcriptionTASpositive regulation of transcription from RNA polymerase II promoterIMPregulation of transcription from RNA polymerase II promoter by glucoseICglucose metabolic processIEApositive regulation of transcription from RNA polymerase II promoter by glucoseIMPresponse to UVISSsequence-specific DNA bindingIDAdouble-stranded DNA bindingIEAprotein kinase bindingIPIhistone deacetylase bindingIPIprotein heterodimerization activityIPItranscription factor activity, RNA polymerase II distal enhancer sequence-specific bindingIDAbHLH transcription factor bindingIPIenzyme bindingIPIprotein homodimerization activityIPIUpstream stimulatory factor 1; Class B basic helix-loop-helix protein 11; bHLHb11; Major late transcription factor 114573800147020391499105615489334167104141797400522497728306960USF1USF1USF1USF1USF1USF1USF1USF1USF1USF1USF1USF1USF1USF1USF1USF1USF1USF1USF1USF1USF1USF1USF1USF1USF1USF1USF1USF1USF1USF1USF1USF1USF1USF1USF1USF1USF1USF1USF1USF1USF1Upstream stimulatory factor 1 Class B basic helix-loop-helix protein 11 bHLHb11 Major late transcription factor 1313C - Cellular Fate and Organizationplasma membraneISSendoplasmic reticulumIDAanchored component of external side of plasma membraneIEAdendriteIEAgrowth coneISScytosolIEAapical plasma membraneIDAintegral component of plasma membraneTASmembrane raftNASfocal adhesionIDAexternal side of plasma membraneISSextracellular exosomeIDAT cell receptor signaling pathwayISSnegative regulation of cell migrationISSretinal cone cell developmentISSangiogenesisISSnegative regulation of T cell receptor signaling pathwayISSpositive regulation of GTPase activityISSsingle organismal cell-cell adhesionISSfocal adhesion assemblyISSpositive regulation of T cell activationISScytoskeleton organizationISSnegative regulation of axonogenesisISSnegative regulation of protein kinase activityISSpositive regulation of release of sequestered calcium ion into cytosolISSGPI anchor bindingISSintegrin bindingIPIThy-1 membrane glycoprotein; CDw90; Thy-1 antigen; CD90; Precursor109444681548933417974005191592181934997328646907683034THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1THY1Thy-1 membrane glycoprotein CDw90 Thy-1 antigen CD90 Precursor2086SPOCK1C - Cellular Fate and OrganizationsarcoplasmISScytoplasmISSnode of RanvierISSneuromuscular junctionISSproteinaceous extracellular matrixIEApostsynaptic densityNASextracellular spaceIDAnegative regulation of endopeptidase activityIDAsignal transductionIEAnegative regulation of neuron projection developmentIDAnegative regulation of cell-substrate adhesionIDAcentral nervous system neuron differentiationISScell adhesionNASneuron migrationISSregulation of cell growthNASneurogenesisISSnervous system developmentNAScysteine-type endopeptidase inhibitor activityIDAserine-type endopeptidase inhibitor activityNASmetalloendopeptidase inhibitor activityIDAcalcium ion bindingIDATestican-1; Protein SPOCK; Precursor14634591470203915372022154893342323436083897049272383TICN1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1SPOCK1Testican-1 Protein SPOCK Precursor165JAM3C - Cellular Fate and OrganizationSchmidt-Lanterman incisureIEAdesmosomeIDAparanodal junctionIEAGolgi apparatusIDAplasma membraneTAScell-cell contact zoneIDAbicellular tight junctionIEAintegral component of membraneIEAextracellular spaceIDAneutrophil homeostasisIEAaxon regenerationIEAleukocyte migration involved in inflammatory responseIEAregulation of actin cytoskeleton organization by cell-cell adhesionIEAmyelinationIEAspermatid developmentIEAestablishment of cell polarityIEAangiogenesisIDAleukocyte migrationTAStransmission of nerve impulseIEAadaptive immune responseIEAcell-matrix adhesionIEAblood coagulationTASextracellular matrix organizationTASregulation of neutrophil chemotaxisIDAmyeloid progenitor cell differentiationIEAintegrin bindingIPIJunctional adhesion molecule C; JAM-C; JAM-2; Junctional adhesion molecule 3; JAM-3; Precursor1159014611739175119449761220888212810109129753091470203915194813153401611548933415994945165548111934997320592283211092242126946023255084JAM3JAM3JAM3JAM3JAM3JAM3JAM3JAM3JAM3JAM3JAM3JAM3JAM3JAM3JAM3JAM3JAM3JAM3JAM3JAM3JAM3JAM3JAM3JAM3JAM3JAM3JAM3JAM3JAM3JAM3JAM3JAM3JAM3JAM3JAM3JAM3JAM3Junctional adhesion molecule C JAM-C JAM-2 Junctional adhesion molecule 3 JAM-3 Precursor165D - Genome MaintenancenucleusIDAregulation of transcription, DNA-templatedIEAtranscription from RNA polymerase II promoterIDAregulation of transcription from RNA polymerase II promoterIDAresponse to corticosteroidIEPspermatogenesisIEAtranscription, DNA-templatedIEAsequence-specific DNA bindingIDARNA polymerase II transcription factor activity, sequence-specific DNA bindingIDATranscription factor SOX-301035984815489334SOX30SOX30SOX30SOX30SOX30Transcription factor SOX-30165C - Cellular Fate and Organizationextracellular matrixNASendoplasmic reticulum lumenTASextracellular regionTAScollagen type V trimerIMPskeletal system developmentIEAcellular response to amino acid stimulusIEAextracellular matrix disassemblyTASossificationIEAextracellular matrix organizationTASaxon guidanceTAScollagen fibril organizationIMPcollagen catabolic processTASeye morphogenesisIMPskin developmentIMPnegative regulation of endodermal cell differentiationIDAmetal ion bindingIEAextracellular matrix structural constituentIEACollagen alpha-2(V) chain; Precursor115662701194070215489334157110815815621182020521757687241173129149272985598302966932249833858826818148294252319783710CO5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2COL5A2Collagen alpha-2(V) chain Precursor165TMEFF1N - Not Matchedplasma membraneIEAintegral component of membraneIEAmulticellular organismal developmentIEATomoregulin-1; TR-1; H7365; Transmembrane protein with EGF-like and one follistatin-like domain; Precursor12743596151640531548933416407223179740058752111TEFF1TMEFF1TMEFF1TMEFF1TMEFF1TMEFF1TMEFF1TMEFF1TMEFF1TMEFF1TMEFF1TMEFF1TMEFF1TMEFF1TMEFF1TMEFF1TMEFF1TMEFF1TMEFF1TMEFF1TMEFF1TMEFF1TMEFF1TMEFF1TMEFF1TMEFF1TMEFF1TMEFF1TMEFF1TMEFF1TMEFF1TMEFF1TMEFF1Tomoregulin-1 TR-1 H7365 Transmembrane protein with EGF-like and one follistatin-like domain Precursor165KIAA0430D - Genome MaintenancemembraneIDAperoxisomeIDAregulation of gene expressionISSoogenesisISSnegative regulation of phosphatase activityIDAfemale meiotic divisionISSdouble-strand break repairIEAnucleotide bindingIEARNA bindingIEAMeiosis arrest female protein 1; Limkain-b11049382914702039154893341561655315932519186696481969033220302647203052679455477MARF1KIAA0430KIAA0430KIAA0430KIAA0430KIAA0430KIAA0430Meiosis arrest female protein 1 Limkain-b1165MIA3C - Cellular Fate and OrganizationmembraneIDAendoplasmic reticulum membraneIDAintegral component of membraneIDAintracellular membrane-bounded organelleIDAnegative regulation of cell migrationIDAnegative regulation of cell adhesionIDApositive regulation of bone mineralizationIEAchondrocyte developmentIEAcollagen fibril organizationIEAwound healingIDApositive regulation of leukocyte migrationIDAprotein transportIMPexocytosisIMPMelanoma inhibitory activity protein 3; C219-reactive peptide; D320; Transport and Golgi organization protein 1; Precursor129753091470203915183315154893341671041417044017183180081866964819159218192693662006823121269460214066922427556977589779039502MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3MIA3Melanoma inhibitory activity protein 3 C219-reactive peptide D320 Transport and Golgi organization protein 1 Precursor165TMEFF2N - Not Matchedextracellular regionIEAintegral component of membraneNASTomoregulin-2; TR-2; Hyperplastic polyposis protein 1; Transmembrane protein with EGF-like and two follistatin-like domains; Precursor106005481090383910987305111208841166849512975309147020391534016115489334158156211643909516805794179424041797400519139490TEFF2TMEFF2TMEFF2TMEFF2TMEFF2TMEFF2TMEFF2TMEFF2TMEFF2Tomoregulin-2 TR-2 Hyperplastic polyposis protein 1 Transmembrane protein with EGF-like and two follistatin-like domains Precursor165KLK5C - Cellular Fate and Organizationepidermal lamellar bodyIDAextracellular spaceTASpositive regulation of G-protein coupled receptor protein signaling pathwayIDAepidermis developmentTASserine-type endopeptidase activityIDAserine-type peptidase activityTASpeptidase activityTASKallikrein-5; 3.4.21.-; Kallikrein-like protein 2; KLK-L2; Stratum corneum tryptic enzyme; Precursor10514489106525631105457412975309150578241536171215489334178810001919077319194479KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5KLK5Kallikrein-5 3.4.21.- Kallikrein-like protein 2 KLK-L2 Stratum corneum tryptic enzyme Precursor165ASPNC - Cellular Fate and Organizationproteinaceous extracellular matrixIDAnegative regulation of tooth mineralizationISSbone mineralizationIDAnegative regulation of transforming growth factor beta receptor signaling pathwayIDAcalcium ion bindingIDAAsporin; Periodontal ligament-associated protein 1; PLAP-1; Precursor1115269211152695115878551297530914702039151640531564080017827158183044941915921819589127ASPNASPNASPNASPNASPNASPNASPNASPNASPNASPNASPNASPNASPNASPNASPNASPNASPNASPNASPNASPNASPNASPNASPNASPNASPNASPNASPNASPNASPNASPNASPNASPNASPNASPNASPNAsporin Periodontal ligament-associated protein 1 PLAP-1 Precursor165C - Cellular Fate and Organizationplasma membraneIEAcell-cell contact zoneIEAintegral component of membraneIEAgrowth coneIEAforebrain developmentIEAhomophilic cell adhesion via plasma membrane adhesion moleculesIEAcalcium ion bindingIEAProtocadherin-9; Precursor150578231548933417974005PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9PCDH9Protocadherin-9 Precursor186NELL1C - Cellular Fate and OrganizationcytoplasmIDAperinuclear region of cytoplasmIDAextracellular regionIEAnuclear envelopeIDAregulation of gene expressionIDApositive regulation of osteoblast differentiationIDAnegative regulation of cyclin catabolic processIDApositive regulation of bone mineralizationIDAnegative regulation of osteoblast proliferationIDAcell differentiationIEAnervous system developmentTAScalcium ion bindingIEAProtein kinase C-binding protein NELL1; NEL-like protein 1; Nel-related protein 1; Precursor14702039154893341655481116959974217232848975702NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1NELL1Protein kinase C-binding protein NELL1 NEL-like protein 1 Nel-related protein 1 Precursor165C - Cellular Fate and Organizationextracellular matrixIMPendoplasmic reticulum lumenTASextracellular regionTAScollagen type V trimerIMPextracellular exosomeIDAbasement membraneIEAblood vessel developmentIEAwound healing, spreading of epidermal cellsIMPeye morphogenesisIMPtendon developmentIEAheart morphogenesisIEAcell migrationIMPextracellular matrix disassemblyTASaxon guidanceTASextracellular matrix organizationTASregulation of cellular component organizationIEAcollagen fibril organizationIMPcollagen catabolic processTASintegrin biosynthetic processIMPskin developmentIMPcollagen biosynthetic processIMPextracellular fibril organizationIMPcell adhesionIMPnegative regulation of endodermal cell differentiationIDAintegrin bindingNASplatelet-derived growth factor bindingIDAproteoglycan bindingIPIheparin bindingIDAmetal ion bindingIEAextracellular matrix structural constituentIEACollagen alpha-1(V) chain; Precursor1047144110602121119924821516405315580559157110817222131897256520715952124875222034762496661818148290429139099729CO5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1COL5A1Collagen alpha-1(V) chain Precursor165RUSC1C - Cellular Fate and OrganizationcytoplasmIDAcell junctionIEAGolgi apparatusISSpostsynaptic membraneIEAmicrotubule cytoskeletonISSmicrotubuleIEAcytoplasmic membrane-bounded vesicleIEApostsynaptic densityIEAnucleusIEAcytoplasmic vesicleISSearly endosomeISSprotein polyubiquitinationIDApositive regulation of signal transductionTASSH3/SH2 adaptor activityTASactin bindingISSRUN and SH3 domain-containing protein 1; New molecule containing SH3 at the carboxy-terminus; Nesca1076059814702039150240331548933416303743167104141797400519365808RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUSC1RUN and SH3 domain-containing protein 1 New molecule containing SH3 at the carboxy-terminus Nesca165HPNC - Cellular Fate and Organizationcell surfaceIDAplasma membraneIDAcell-cell junctionISSintegral component of plasma membraneIDAneuronal cell bodyISSendoplasmic reticulum membraneIDAintegral component of membraneIDAextracellular exosomeIDAcholesterol homeostasisIEAnegative regulation of apoptotic processIDAresponse to thyroid hormoneISSpositive regulation of cell growthIMPregulation of cell shapeIMPpilomotor reflexISSnegative regulation of epithelial cell proliferationIDApositive regulation of hepatocyte proliferationIDAnegative regulation of epithelial to mesenchymal transitionIDApositive regulation by host of viral transcriptionIDAnegative regulation of alkaline phosphatase activityIEApositive regulation of gene expressionISSpositive regulation of plasminogen activationIDAdetection of mechanical stimulus involved in sensory perception of soundISSproteolysisIDAcochlea morphogenesisISSpositive regulation of thyroid hormone generationISSpotassium ion transmembrane transportISSbasement membrane disassemblyIDAserine-type endopeptidase activityIDAserine-type peptidase activityIDApeptidase activityIDAcalcium-activated potassium channel activityISSserine-type exopeptidase activityIEASerine protease hepsin; 3.4.21.106; Transmembrane protease serine 1; Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain14702039154893341583983718856211915921821875933242278432427556928350768346233HEPSHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNHPNSerine protease hepsin 3.4.21.106 Transmembrane protease serine 1 Serine protease hepsin non-catalytic chain Serine protease hepsin catalytic chain165C - Cellular Fate and Organizationplasma membraneIEAmembraneTASanchored component of membraneIEAextracellular exosomeIDApositive regulation of gene expressionIEANotch signaling pathwayTASaxon guidanceTASpositive regulation of sodium ion transportIEApositive regulation of neuron projection developmentIEAcerebellum developmentIEAcell adhesionNAScarbohydrate bindingIEAContactin-1; Glycoprotein gp135; Neural cell surface protein F3; Precursor14702039154893341633595216959974190263981913949020133774202617379597348164510CNTN1CNTN1CNTN1CNTN1CNTN1CNTN1CNTN1CNTN1CNTN1CNTN1CNTN1CNTN1CNTN1CNTN1CNTN1CNTN1CNTN1CNTN1CNTN1CNTN1CNTN1CNTN1CNTN1CNTN1CNTN1CNTN1CNTN1CNTN1CNTN1CNTN1CNTN1CNTN1CNTN1CNTN1CNTN1CNTN1CNTN1Contactin-1 Glycoprotein gp135 Neural cell surface protein F3 Precursor210CREBBPD - Genome Maintenancenuclear bodyIDAtranscription factor complexIEAcytoplasmIDAcondensed chromosome outer kinetochoreIEAnuclear chromatinIDAhistone acetyltransferase complexIEAnucleoplasmIDAnucleusIDAgene expressionTAStranscription initiation from RNA polymerase II promoterTASchromatin organizationTASregulation of transcription from RNA polymerase II promoter in response to hypoxiaTASN-terminal peptidyl-lysine acetylationIDAsmall molecule metabolic processTAScellular response to heatTASNotch signaling pathwayTASviral processIEApositive regulation of type I interferon productionTASgerm-line stem cell population maintenanceIEAcellular lipid metabolic processTASresponse to hypoxiaTASregulation of transcription, DNA-templatedTAShistone acetylationIDAcellular response to hypoxiaTAShomeostatic processNASnegative regulation of transcription from RNA polymerase II promoterIDAsignal transductionNASprotein complex assemblyTASregulation of smoothened signaling pathwayTASinnate immune responseTASrhythmic processIEApositive regulation of transcription, DNA-templatedIDAembryonic digit morphogenesisTASregulation of cellular response to heatTAScore promoter proximal region sequence-specific DNA bindingIDAtranscriptional repressor activity, RNA polymerase II transcription factor bindingIDARNA polymerase II activating transcription factor bindingTASRNA polymerase II transcription coactivator activityTAStranscription factor activity, sequence-specific DNA bindingTAStranscription coactivator activityIDAMRF bindingIDAtranscriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific bindingIDAp53 bindingIPIchromatin bindingIEARNA polymerase II transcription factor bindingIPIacetyltransferase activityIDAzinc ion bindingIEAsignal transducer activityTAShistone acetyltransferase activityIDAtranscription factor bindingIPICREB-binding protein; 2.3.1.48 {ECO:0000269|PubMed:24616510}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-binding protein 2.3.1.48 {ECO:0000269|PubMed:24616510}165ABI2C - Cellular Fate and OrganizationSCAR complexIDAcytoplasmTASfilopodiumIDAcytoskeletonIEAlamellipodiumIDAcytosolIDARac protein signal transductionIDAcell migrationTASactin polymerization or depolymerizationNAScytoskeleton organizationTASmovement of cell or subcellular componentIDApeptidyl-tyrosine phosphorylationIDApositive regulation of Arp2/3 complex-mediated actin nucleationIDASH3 domain bindingIPIkinase bindingNASDNA bindingTASprotein complex bindingIDAproline-rich region bindingIPIcytoskeletal adaptor activityTASubiquitin protein ligase bindingIPIAbl interactor 2; Abelson interactor 2; Abi-2; Abl-binding protein 3; AblBP3; Arg-binding protein 1; ArgBP110498863115166531470203915489334186696482006823121107423212694602140669275902368649853ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2ABI2Abl interactor 2 Abelson interactor 2 Abi-2 Abl-binding protein 3 AblBP3 Arg-binding protein 1 ArgBP1165PVRL1C - Cellular Fate and Organizationpresynaptic membraneIEAaxonIEAcell-cell adherens junctionIDAmembraneTASadherens junctionNASplasma membraneTASgrowth cone membraneIEAcatenin complexIEAextracellular regionIEAintegral component of membraneNASintracellular membrane-bounded organelleIEAregulation of synapse assemblyIEAretina development in camera-type eyeIEAcell junction assemblyTASenamel mineralizationIEAviral entry into host cellNAScell-cell junction organizationTASsignal transductionTASimmune responseNASsingle organismal cell-cell adhesionNASdesmosome organizationIEAlens morphogenesis in camera-type eyeIEAaxon guidanceIEAiron ion transportIEAcell adhesionNAShomophilic cell adhesion via plasma membrane adhesion moleculesISSheterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesISSadherens junction organizationTASvirus receptor activityIEAvirion bindingIEAcarbohydrate bindingIEAcoreceptor activityTAScell adhesion molecule bindingIPIprotein homodimerization activityISSNectin-1; Herpes virus entry mediator C; Herpesvirus entry mediator C; HveC; Herpesvirus Ig-like receptor; HIgR; Poliovirus receptor-related protein 1; CD111; Precursor102259551093218811356977115442541548933416335952166795151913949019349973196903322140669221980294221463962290236724275569772110296161279696799PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1PVRL1Nectin-1 Herpes virus entry mediator C Herpesvirus entry mediator C HveC Herpesvirus Ig-like receptor HIgR Poliovirus receptor-related protein 1 CD111 Precursor165THBS2C - Cellular Fate and Organizationplatelet alpha granuleIDAextracellular regionTASbasement membraneIEApositive regulation of synapse assemblyIEAnegative regulation of angiogenesisIDAcell adhesionIEAcalcium ion bindingIEAheparin bindingTASThrombospondin-2; Precursor1159013813716761457440414702039154893341559694161868191845513018499674207148028406456TSP2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2THBS2Thrombospondin-2 Precursor165FSTL5N - Not Matchedextracellular regionIEAcalcium ion bindingIEAFollistatin-related protein 5; Follistatin-like protein 5; Precursor105744621470203915489334158156211695997417974005FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5FSTL5Follistatin-related protein 5 Follistatin-like protein 5 Precursor165C - Cellular Fate and Organizationbrush borderIEAneuron projectionIEAperinuclear region of cytoplasmIEAmembraneIEAneuronal cell bodyIEApostsynaptic densityIEAapical part of cellIEAcytosolIEAsmall GTPase mediated signal transductionIEAresponse to drugIEAcell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migrationIEAradial glia guided migration of Purkinje cellIEAventral spinal cord developmentIEAdendrite developmentIEAnegative regulation of JAK-STAT cascadeIEAcerebellum structural organizationIEAnegative regulation of astrocyte differentiationIEAnegative regulation of cell adhesionIEAlateral motor column neuron migrationIEApositive regulation of neuron differentiationIEAmidgut developmentIEApositive regulation of protein kinase activityIEAcerebral cortex radially oriented cell migrationIEAadult walking behaviorIEAnegative regulation of axonogenesisIEAGolgi localizationIEADisabled homolog 1147020391527200315489334167104149790777DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1DAB1Disabled homolog 1165PRSS2F - Protein Fateextracellular matrixTASextracellular regionIDAextracellular spaceIMPextracellular matrix disassemblyTASextracellular matrix organizationTASpositive regulation of cell growthTASinnate immune responseTASdigestionIEAcollagen catabolic processIDAproteolysisIDApositive regulation of cell adhesionTASserine-type endopeptidase activityIDAcalcium ion bindingIDATrypsin-2; 3.4.21.4; Anionic trypsinogen; Serine protease 2; Trypsin II; Precursor1202177617087724189863052501048925984663011602TRY2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2PRSS2Trypsin-2 3.4.21.4 Anionic trypsinogen Serine protease 2 Trypsin II Precursor179SOCS5C - Cellular Fate and OrganizationcytoplasmIBAprotein ubiquitinationIEAcytokine-mediated signaling pathwayISSpositive regulation of proteasomal ubiquitin-dependent protein catabolic processIMPJAK-STAT cascadeIEAnegative regulation of JAK-STAT cascadeIBAepidermal growth factor receptor signaling pathwayIEAnegative regulation of T-helper 2 cell differentiationISSnegative regulation of epidermal growth factor-activated receptor activityIDApositive regulation of T-helper 1 cell differentiationISScell growthNASnegative regulation of signal transductionNASregulation of growthIEAreceptor tyrosine kinase bindingIPIprotein kinase inhibitor activityIBASuppressor of cytokine signaling 5; SOCS-5; Cytokine-inducible SH2 protein 6; CIS-6; Cytokine-inducible SH2-containing protein 51077367111230166147020391548933415590694158156219734811SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5SOCS5Suppressor of cytokine signaling 5 SOCS-5 Cytokine-inducible SH2 protein 6 CIS-6 Cytokine-inducible SH2-containing protein 5170ARHGEF7C - Cellular Fate and Organizationneuron projectionIDAprotein complexIDAneuronal cell bodyIDAruffleIEAfocal adhesionIDAcell cortexIEAlamellipodiumISScytosolTASregulation of small GTPase mediated signal transductionTASneurotrophin TRK receptor signaling pathwayTASpositive regulation of apoptotic processIMPephrin receptor signaling pathwayTASsmall GTPase mediated signal transductionTASpositive regulation of lamellipodium morphogenesisIMPlamellipodium assemblyISSnegative regulation of epidermal growth factor receptor signaling pathwayTASapoptotic signaling pathwayTASpositive regulation of GTPase activityIDAsignal transductionTASpositive regulation of fibroblast migrationIDAepidermal growth factor receptor signaling pathwayTASpositive regulation of substrate adhesion-dependent cell spreadingIMPaxon guidanceTAShematopoietic progenitor cell differentiationIEAfocal adhesion assemblyIDAguanyl-nucleotide exchange factor activityIDAprotein kinase bindingIPIRho guanyl-nucleotide exchange factor activityIEARho guanine nucleotide exchange factor 7; Beta-Pix; COOL-1; PAK-interacting exchange factor beta; p851288096115057823151826721548933415491607161012811797400518184567186696481871632319041750191181891969033221248752212694602140669221926430228143782328502724275569859028097269649846881ARHG7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7ARHGEF7Rho guanine nucleotide exchange factor 7 Beta-Pix COOL-1 PAK-interacting exchange factor beta p85177TRIM37 {ECO:0000312|HGNC:HGNC:7523}T - TranscriptionintracellularIEAcytoplasmIDAperinuclear region of cytoplasmIEAaggresomeIDAperoxisomeIDAcytosolIDAhistone H2A monoubiquitinationIDApositive regulation of sequence-specific DNA binding transcription factor activityIDApositive regulation of NF-kappaB transcription factor activityIDAaggresome assemblyIDAnegative regulation of NF-kappaB transcription factor activityIDAnegative regulation of transcription from RNA polymerase II promoterIDAhistone H2A-K119 monoubiquitinationIDAnegative regulation of centriole replicationIMPprotein autoubiquitinationIDAtumor necrosis factor receptor bindingIPIubiquitin-protein transferase activityIDAchromatin bindingIEAligase activityIEAzinc ion bindingIEAubiquitin protein ligase activityIDAubiquitin protein ligase bindingIPIprotein homodimerization activityIDAE3 ubiquitin-protein ligase TRIM37 {ECO:0000305}; 6.3.2.- {ECO:0000269|PubMed:15885686}; Mulibrey nanism protein {ECO:0000303|PubMed:10888877}; Tripartite motif-containing protein 37 {ECO:0000305}10048485108888771193849412754710147020391510828515489334158856861631097616625196171009911755133117974005218653622281437823385855237699722431772425470042TRI37TRIM37TRIM37TRIM37TRIM37TRIM37TRIM37TRIM37TRIM37TRIM37TRIM37TRIM37TRIM37TRIM37TRIM37TRIM37TRIM37TRIM37TRIM37TRIM37TRIM37TRIM37TRIM37TRIM37TRIM37TRIM37TRIM37TRIM37TRIM37TRIM37TRIM37TRIM37TRIM37TRIM37TRIM37TRIM37TRIM37TRIM37TRIM37E3 ubiquitin-protein ligase TRIM37 {ECO:0000305} 6.3.2.- {ECO:0000269|PubMed:15885686} Mulibrey nanism protein {ECO:0000303|PubMed:10888877} Tripartite motif-containing protein 37 {ECO:0000305}174C - Cellular Fate and OrganizationcytoplasmIDAplasma membraneIEAanchored component of membraneIEAsensory perception of soundIEAcell adhesionIEAContactin-5; Neural recognition molecule NB-2; hNB-2; Precursor11013081154893341655481120133774CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5CNTN5Contactin-5 Neural recognition molecule NB-2 hNB-2 Precursor165C - Cellular Fate and Organizationextracellular matrixIEAmelanosomeIEAplasma membraneIDAintegral component of plasma membraneTASGolgi lumenTASfocal adhesionIDAresponse to estrogenIEAtissue remodelingIEAlung developmentIEApositive regulation of cell growthIDAendodermal cell differentiationIEPchondrocyte proliferationIEAembryonic cranial skeleton morphogenesisIEAnegative regulation of focal adhesion assemblyIEAovarian follicle developmentIEAextracellular matrix disassemblyTASextracellular matrix organizationTAScollagen catabolic processTASproteolysisIDAresponse to oxidative stressIEAcraniofacial suture morphogenesisIEAresponse to hypoxiaIEApositive regulation of cell migrationIDAangiogenesisIEAastrocyte cell migrationIEAresponse to mechanical stimulusIEAendochondral ossificationIEAendothelial cell proliferationIEAbranching morphogenesis of an epithelial tubeIEAmale gonad developmentIEAzymogen activationIEApeptidase activator activityIEAtranscription factor activity, sequence-specific DNA bindingIEAcalcium ion bindingIEAzinc ion bindingTASmetalloendopeptidase activityTASMatrix metalloproteinase-14; MMP-14; 3.4.24.80; MMP-X1; Membrane-type matrix metalloproteinase 1; MT-MMP 1; MTMMP1; Membrane-type-1 matrix metalloproteinase; MT1-MMP; MT1MMP; Precursor125081211271465714702039154893341708106518223680208374842206532122922033251714057649159770871577211078015608870672688044349724659MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14MMP14Matrix metalloproteinase-14 MMP-14 3.4.24.80 MMP-X1 Membrane-type matrix metalloproteinase 1 MT-MMP 1 MTMMP1 Membrane-type-1 matrix metalloproteinase MT1-MMP MT1MMP Precursor197MAPK3D - Genome MaintenanceGolgi apparatusTASlate endosomeTASnucleusTASnuclear envelopeIDAcytosolTASpseudopodiumIEAmitochondrionTAScaveolaTASmicrotubule cytoskeletonIDAnucleoplasmIDAcytoskeletonTASfocal adhesionTASearly endosomeTASextracellular exosomeIDAgene expressionTAScartilage developmentIEAcaveolin-mediated endocytosisTAScytokine-mediated signaling pathwayTAStranscription initiation from RNA polymerase I promoterTAStranscription from RNA polymerase I promoterTASstress-activated MAPK cascadeTASnegative regulation of apolipoprotein bindingIEAcellular response to heatTASMyD88-independent toll-like receptor signaling pathwayTASepidermal growth factor receptor signaling pathwayTASaxon guidanceTASMAPK cascadeNASMyD88-dependent toll-like receptor signaling pathwayTASorgan morphogenesisIEApositive regulation of ERK1 and ERK2 cascadeIMPlipopolysaccharide-mediated signaling pathwayIEApeptidyl-tyrosine autophosphorylationIDAtoll-like receptor TLR6:TLR2 signaling pathwayTAStoll-like receptor TLR1:TLR2 signaling pathwayTAStoll-like receptor 2 signaling pathwayTASplatelet activationTASBMP signaling pathwayIMPtoll-like receptor signaling pathwayTASresponse to epidermal growth factorIDAphosphorylationIDAcell cycleIEAregulation of cytoskeleton organizationTASfibroblast growth factor receptor signaling pathwayTASinnate immune responseTAStoll-like receptor 10 signaling pathwayTASTRIF-dependent toll-like receptor signaling pathwayTASFc-gamma receptor signaling pathway involved in phagocytosisTAStoll-like receptor 9 signaling pathwayTASFc-epsilon receptor signaling pathwayTASinsulin receptor signaling pathwayTAStoll-like receptor 4 signaling pathwayTASsmall GTPase mediated signal transductionTASRas protein signal transductionTASJAK-STAT cascade involved in growth hormone signaling pathwayTASregulation of stress-activated MAPK cascadeTASpositive regulation of histone acetylationIMPregulation of sequence-specific DNA binding transcription factor activityTASactivation of MAPK activityTASactivation of MAPKK activityTASpositive regulation of transcription from RNA polymerase II promoterIMPviral processIEAtoll-like receptor 3 signaling pathwayTASinterleukin-1-mediated signaling pathwayIMPvascular endothelial growth factor receptor signaling pathwayTASneurotrophin TRK receptor signaling pathwayTASregulation of early endosome to late endosome transportTASregulation of Golgi inheritanceTASapoptotic processIEAsensory perception of painIEADNA damage induced protein phosphorylationIDApositive regulation of histone phosphorylationIMPblood coagulationTASpositive regulation of protein phosphorylationIMPprotein phosphorylationIDAcellular response to mechanical stimulusIEPtoll-like receptor 5 signaling pathwayTASresponse to exogenous dsRNAIEAregulation of cellular response to heatTASphosphatase bindingIPIATP bindingIEAMAP kinase activityIDAMitogen-activated protein kinase 3; MAP kinase 3; MAPK 3; 2.7.11.24; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p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itogen-activated protein kinase 3 MAP kinase 3 MAPK 3 2.7.11.24 ERT2 Extracellular signal-regulated kinase 1 ERK-1 Insulin-stimulated MAP2 kinase MAP kinase isoform p44 p44-MAPK Microtubule-associated protein 2 kinase p44-ERK1165BIN1D - Genome MaintenanceaxonIDAZ discISScerebellar mossy fiberIEAT-tubuleISSnucleusIEAactin cytoskeletonTASsynaptic vesicleIEAaxon initial segmentISScytoplasmIDAnode of RanvierISSlipid tubeIMPmembraneIDAvaricosityIEAaxon terminusIEAI bandISSmuscle cell differentiationIEApositive regulation of GTPase activityIEApositive regulation of endocytosisIEAregulation of cell cycle arrestIDAlipid tube assemblyIMPpositive regulation of apoptotic processIDApositive regulation of astrocyte differentiationIMPcell proliferationTASregulation of neuron differentiationIMPviral processIEAendocytosisIEAtau protein bindingIPIRNA polymerase bindingIPIidentical protein bindingIPIMyc box-dependent-interacting protein 1; Amphiphysin II; Amphiphysin-like protein; Box-dependent myc-interacting protein 1; Bridging integrator 1109038461581562116530520170819831767604217974005186696481936772019413330196903322006823122814378242755698782822918266791959869223448939547994189039603201BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1BIN1Myc box-dependent-interacting protein 1 Amphiphysin II Amphiphysin-like protein Box-dependent myc-interacting protein 1 Bridging integrator 1165CD200R - Stress and Defenceplasma membraneTASintegral component of plasma membraneTASregulation of immune responseTASOX-2 membrane glycoprotein; CD200; Precursor147020391548933416303743166419973032785OX2GCD200CD200CD200CD200CD200CD200CD200CD200CD200CD200CD200CD200CD200CD200CD200CD200CD200CD200CD200CD200CD200CD200CD200CD200CD200CD200CD200CD200CD200CD200CD200CD200CD200CD200CD200CD200CD200CD200CD200CD200CD200CD200OX-2 membrane glycoprotein CD200 Precursor165LAMA2C - Cellular Fate and OrganizationsarcolemmaIEAdendritic spineIEAlaminin-1 complexIEAextracellular regionTASbasement membraneIDAextracellular exosomeIDAregulation of cell migrationIEAregulation of embryonic developmentIEApositive regulation of synaptic transmission, cholinergicIEAmuscle organ developmentTASaxon guidanceIEAextracellular matrix organizationTASmyelination in peripheral nervous systemIEAcell adhesionIEAregulation of cell adhesionIEAstructural molecule activityTASLaminin subunit alpha-2; Laminin M chain; Laminin-12 subunit alpha; Laminin-2 subunit alpha; Laminin-4 subunit alpha; Merosin heavy chain; Precursor1159185812552556145744041633595216959974191592182185464753576282945198910357LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2LAMA2Laminin subunit alpha-2 Laminin M chain Laminin-12 subunit alpha Laminin-2 subunit alpha Laminin-4 subunit alpha Merosin heavy chain Precursor207TWIST2C - Cellular Fate and Organizationtranscription factor complexIEAcytoplasmIDAnucleusIDApositive regulation of keratinocyte proliferationIEAnegative regulation of apoptotic processIEAnegative regulation of cell proliferationIEAnegative regulation of tumor necrosis factor productionIEAnegative regulation of transcription from RNA polymerase II promoterIEAembryonic cranial skeleton morphogenesisIEAosteoblast differentiationIEAnegative regulation of DNA bindingIEAcornea development in camera-type eyeIEAnegative regulation of osteoblast differentiationIDAface morphogenesisIEAnegative regulation of myeloid cell differentiationIEAnegative regulation of transcription, DNA-templatedISStranscription factor activity, RNA polymerase II transcription factor bindingIEAtranscription factor activity, sequence-specific DNA bindingIEAchromatin bindingIEADNA bindingIEATwist-related protein 2; Class A basic helix-loop-helix protein 39; bHLHa39; Dermis-expressed protein 1; Dermo-1110623441548933420691403TWST2TWIST2TWIST2TWIST2TWIST2TWIST2TWIST2TWIST2TWIST2TWIST2TWIST2TWIST2TWIST2TWIST2TWIST2TWIST2TWIST2TWIST2TWIST2TWIST2TWIST2TWIST2TWIST2TWIST2TWIST2TWIST2TWIST2TWIST2TWIST2TWIST2TWIST2Twist-related protein 2 Class A basic helix-loop-helix protein 39 bHLHa39 Dermis-expressed protein 1 Dermo-1165FSTL3D - Genome Maintenanceneuron projection terminusIEAGolgi apparatusIEAnucleoplasmIDAnucleusIDAextracellular regionTASsecretory granuleIEAextracellular spaceIDApositive regulation of cell-cell adhesionIDAregulation of transcription from RNA polymerase II promoterIDAadrenal gland developmentIEAkidney developmentIEAlung developmentIEAnegative regulation of activin receptor signaling pathwayIDAnegative regulation of osteoclast differentiationIDAspermatogenesisIEAtranscription, DNA-templatedIEAnegative regulation of BMP signaling pathwayIDAcellular response to metal ionIEAossificationIEAhematopoietic progenitor cell differentiationIDApositive regulation of transcription from RNA polymerase II promoterIDAnegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathwayIDAmale gonad developmentIEAactivin bindingIPIfibronectin bindingIPIFollistatin-related protein 3; Follistatin-like protein 3; Follistatin-related gene protein; Precursor114597871194840512697670129703211297530914702039153401611545157515489334155741241615090516336961178680291787867718768470220529139671416FSTL3FSTL3FSTL3FSTL3FSTL3FSTL3FSTL3FSTL3FSTL3FSTL3FSTL3FSTL3FSTL3FSTL3FSTL3FSTL3FSTL3FSTL3FSTL3FSTL3FSTL3FSTL3FSTL3FSTL3FSTL3FSTL3FSTL3FSTL3FSTL3FSTL3FSTL3Follistatin-related protein 3 Follistatin-like protein 3 Follistatin-related gene protein Precursor195NTN1C - Cellular Fate and OrganizationcytoplasmIEAextracellular regionTASbasement membraneIEAregulation of cell migrationIEApositive regulation of cell proliferationIEAinner ear morphogenesisIEApositive regulation of axon extensionIEAapoptotic processIEAanterior/posterior axon guidanceIEAsingle organismal cell-cell adhesionIEAestablishment of nucleus localizationIEAaxon guidanceTASnegative regulation of axon extensionIEAneuron migrationIEAmammary gland duct morphogenesisIEANetrin-1; Epididymis tissue protein Li 131P; Precursor153433351662519619196994207364099950216NET1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1NTN1Netrin-1 Epididymis tissue protein Li 131P Precursor166C - Cellular Fate and OrganizationcytoplasmIEAplasma membraneTASintegral component of membraneIEAextracellular exosomeIDAskeletal system developmentTASossificationNAScorticospinal tract morphogenesisIEAcell junction assemblyTAScell adhesionTAShomophilic cell adhesion via plasma membrane adhesion moleculesIEAcell-cell junction organizationTASadherens junction organizationTAScalcium ion bindingIEACadherin-11; OSF-4; Osteoblast cadherin; OB-cadherin; Precursor147020391502632415616553205965879820338163513CAD11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11CDH11Cadherin-11 OSF-4 Osteoblast cadherin OB-cadherin Precursor6predother26expexplung and brainlung and brain28orthoortholung and brainlung and brain1predpredlung and brainlung and brain3predpredbrainbrain2predpredlung and brainlung and brain1predpredbrainbrain14predpredlung and brainlung and brain30predlung and brain11predpredlung and brainlung and brain4predpredlung and brainlung and brain5predpredlung and brainlung and brain26predpredlung and brainlung and brain28predpredlung and brainlung and brain6predpredlung and brainlung and brain14predpredlung and brainlung and brain32predpredlung and brainlung and brain6predpredbrainbrain2predpredlung and brainlung and brain10predpredlung and brainlung and brain3predpredlung and brainlung and brain20expexplung and brainlung and brain15predbrain19predpredlung and brainlung and brain2predpredbrainbrain9predpredlung and brainlung and brain6predpredotherother1predpredlung and brainlung and brain4predpredotherother0expexpbrainbrain9predpredlung and brainlung and brain1predpredbrainbrain78predpredlung and brainlung and brain0expexplung and brainlung and brain20predpredlung and brainlung and brain40predpredotherother46predpredlung and brainlung and brain5predpredlung and brainlung and brain1orthoortholung and brainlung and brain4predpredlung and brainlung and brain0predpredlung and brainlung and brain12predpredlung and brainlung and brain74predlung and brain2predpredlung and brainlung and brain0expexplung and brainlung and brain11predpredbrainbrain6predbrain6predpredlung and brainlung and brain1predpredlung and brainlung and brain6predpredlung and brainlung and brain12predpredbrainbrain17predpredlung and brainlung and brain0orthoortholung and brainlung and brain18predpredlung and brainlung and brain23expexplung and brainlung and brain4predlung and brain0predpredbrainbrain6predpredlung and brainlung and brain2predpredlung and brainlung and brain56predlung and brain32predpredotherother7predpredlung and brainlung and brain4predpredlung and brainlung and brain4predpredotherother12predpredotherother4predpredlung and brainlung and brain1predpredlung and brainlung and brain0expexplung and brainlung and brain16predpredlunglung32predpredlung and brainlung and brain6predpredlung and brainlung and brain39predpredbrainbrain16predpredlung and brainlung and brain4expexplung and brainlung and brain3predpredlung and brainlung and brain10predpredlunglung3predpredlung and brainlung and brain2predpredlung and brainlung and brain29predpredotherother1predpredlung and brainlung and brain25expexplung and brainlung and brain2predpredlung and brainlung and brain0expexplung and brainlung and brain2predpredlung and brainlung and brain7expexplung and brainlung and brain0predpredlung and brainlung and brain2predpredlung and brainlung and brain71predlung and brain2predpredlung and brainlung and brain13predpredlung and brainlung and brain1predpredlunglung7predpredotherother5predpredlung and brainlung and brain36predpredotherother4predpredbrainbrain4expother1predpredbrainbrain8predbrain5predpredotherother2predpredotherother29predpredlung and brainlung and brain9predpredbrainbrain7predpredlung and brainlung and brain13predpredlung and brainlung and brain27predpredlung and brainlung and brain1predpredlung and brainlung and brain1predpredlunglung1predpredlung and brainlung and brain9expexplung and brainlung and brain50predpredlung and brainlung and brain30predlung and brain4predpredlung and brainlung and brain2predpredlung and brainlung and brain5predpredlung and brainlung and brain104expexplung and brainlung and brain11predpredlung and brainlung and brain8predpredlung and brainlung and brain3predpredlung and brainlung and brain26predpredlung and brainlung and brain3predpredlung and brainlung and brain1predpredlung and brainlung and brain5predpredlung and brainlung and brain30predpredlung and brainlung and brain9predpredlung and brainlung and brain3predpredlung and brainlung and brain13expexplung and brainlung and brain9predpredotherother1predpredlung and brainlung and brain21expexplung and brainlung and brain4predpredlung and brainlung and brain0expexplung and brainlung and brain1predpredlung and brainlung and brain1predpredbrainbrain22predlung16predpredlung and brainlung and brain6predpredlung and brainlung and brain28predpredlung and brainlung and brain8predpredlung and brainlung and brain4predpredlung and brainlung and brain54predlung and brain33predpredbrainbrain8predpredlung and brainlung and brain4predpredbrainbrain22predpredbrainbrain2predpredbrainbrain1predpredlung and brainlung and brain2predpredbrainbrain6predpredlung and brainlung and brain16expexplung and brainlung and brain45predpredbrainbrain10predpredlung and brainlung and brain3predpredlung and brainlung and brain0predpredlung and brainlung and brain3predpredlung and brainlung and brain10predlung and brain12predpredlung and brainlung and brain4predpredlunglung6expexplung and brainlung and brain0expexplung and brainlung and brain1predpredlung and brainlung and brain20predpredlung and brainlung and brain16predpredlung and brainlung and brain5predpredlung and brainlung and brain1predpredlung and brainlung and brain1predpredlung and brainlung and brain3predpredotherother5predpredlung and brainlung and brain30predpredlunglung52predbrain3expexplung and brainlung and brain2predpredbrainbrain4expexplung and brainlung and brain2expexplung and brainlung and brain4predpredbrainbrain2predpredbrainbrain7predother1predpredlung and brainlung and brain1predpredlung and brainlung and brain5predpredlung and brainlung and brain1predpredlung and brainlung and brain3predpredlung and brainlung and brain15predpredlunglung56expexplung and brainlung and brain0expexplung and brainlung and brain1predpredlung and brainlung and brain2predpredbrainbrain9predpredlung and brainlung and brain1predpredotherother7predpredlung and brainlung and brain5predpredlung and brainlung and brain35predbrain0predpredlung and brainlung and brain1predpredlung and brainlung and brain10predpredotherother5predpredlung and brainlung and brain28predpredlung and brainlung and brain3predpredlung and brainlung and brain1expexplung and brainlung and brain2predpredbrainbrain19predpredlung and brainlung and brain13predpredlung and brainlung and brain16predpredlunglung13predpredlung and brainlung and brain5expexplung and brainlung and brain17predpredlung and brainlung and brain15predpredlung and brainlung and brain16expexplung and brainlung and brain1predpredbrainbrain2predpredlung and brainlung and brain1predpredlung and brainlung and brain1predpredlung and brainlung and brain0expexplung and brainlung and brain20predpredlung and brainlung and brain6predpredlunglung21expexplung and brainlung and brain5predpredotherother19expexplung and brainlung and brain18predbrain3predpredlunglung3predpredotherother1predpredotherother3predpredlung and brainlung and brain17predpredlung and brainlung and brain22predpredbrainbrain2predpredlung and brainlung and brain0expexplung and brainlung and brain17predpredlung and brainlung and brain12predpredbrainbrain7predpredlung and brainlung and brain1predpredlung and brainlung and brain2predpredbrainbrain26predpredlung and brainlung and brain6expexplung and brainlung and brain5predpredlung and brainlung and brain8predpredbrainbrain2predpredlung and brainlung and brain43predpredlung and brainlung and brain40expexplung and brainlung and brain4predpredbrainbrain5predpredlung and brainlung and brain20predpredlung and brainlung and brain4expexplung and brainlung and brain12predpredlung and brainlung and brain17predpredotherother26predlung and brain31expexplung and brainlung and brain9predpredbrainbrain19predpredlung and brainlung and brain1predpredlung and brainlung and brain3predpredbrainbrain6predpredbrainbrain4predpredotherother10predpredlung and brainlung and brain6predpredlung and brainlung and brain67predpredlung and brainlung and brain4predpredlunglung12predpredlung and brainlung and brain19predpredlung and brainlung and brain58predbrain13predpredlung and brainlung and brain8predpredlung and brainlung and brain3predpredlung and brainlung and brain4predpredlung and brainlung and brain11predpredlung and brainlung and brain1predpredlunglung12predpredlung and brainlung and brain16predpredlung and brainlung and brain1predpredbrainbrain6predpredlung and brainlung and brain6predpredlung and brainlung and brain16orthoortholung and brainlung and brain116expexplung and brainlung and brain9predpredlung and brainlung and brain24predpredlung and brainlung and brain8predpredlung and brainlung and brain6predpredlung and brainlung and brain0expexplung and brainlung and brain10predpredlung and brainlung and brain3predpredlung and brainlung and brain37predpredotherother5predpredlung and brainlung and brain6predpredlung and brainlung and brain27predpredbrainbrain13explung and brain1predpredlung and brainlung and brain33expexplung and brainlung and brain47expexplung and brainlung and brain10predpredlung and brainlung and brain42predlung and brain12predpredlung and brainlung and brain5predpredlung and brainlung and brain49predpredlunglung3predpredlung and brainlung and brain3predpredlung and brainlung and brain24predpredlung and brainlung and brain76explung and brain16predpredotherother5predpredotherother5predpredlung and brainlung and brain25predpredlunglung24predpredotherother3predpredlung and brainlung and brain4predpredbrainbrain13predpredbrainbrain2predpredlung and brainlung and brain1predpredlung and brainlung and brain3predpredlung and brainlung and brain3predpredbrainbrain1predpredbrainbrain15predpredlung and brainlung and brain45predpredotherother1predpredlung and brainlung and brain0orthoortholung and brainlung and brain8predlung2predpredlung and brainlung and brain10predpredlung and brainlung and brain1predpredlung and brainlung and brain10predlung and brain1predpredlung and brainlung and brain3predpredlung and brainlung and brain5predpredlung and brainlung and brain55predbrain0predpredlung and brainlung and brain5expexplung and brainlung and brain4predpredlung and brainlung and brain5predpredlung and brainlung and brain1predpredlung and brainlung and brain4predpredbrainbrain39predpredlunglung14predpredlung and brainlung and brain0expexplung and brainlung and brain56expexplung and brainlung and brain2predpredlung and brainlung and brain0orthoortholung and brainlung and brain1predpredlung and brainlung and brain6predpredlung and brainlung and brain60predpredlunglung2predpredbrainbrain2predpredlung and brainlung and brain4predpredlung and brainlung and brain1predpredlung and brainlung and brain4expexplunglung9predpredlunglung26predpredlung and brainlung and brain3predpredbrainbrain9predpredlung and brainlung and brain0expexplung and brainlung and brain1predpredlung and brainlung and brain11predpredbrainbrain6predpredlung and brainlung and brain7predpredlung and brainlung and brain13predpredbrainbrain1predpredlung and brainlung and brain1predpredlunglung4predpredlung and brainlung and brain1predpredlung and brainlung and brain2expexplung and brainlung and brain16predpredlung and brainlung and brain2predpredlung and brainlung and brain11predpredbrainbrain8predbrain6predbrain2predpredbrainbrain2predpredlung and brainlung and brain3predpredbrainbrain4predpredlung and brainlung and brain11expexplung and brainlung and brain1predpredlung and brainlung and brain5predpredlung and brainlung and brain5predpredlung and brainlung and brain2predpredbrainbrain8predpredlung and brainlung and brain10predpredlung and brainlung and brain21predpredlung and brainlung and brain1predpredlung and brainlung and brain2predpredlung and brainlung and brain0predpredlung and brainlung and brain4predpredlung and brainlung and brain4predpredlung and brainlung and brain27predpredbrainbrain12predpredlung and brainlung and brain2predpredlung and brainlung and brain3predpredlung and brainlung and brain49predpredlung and brainlung and brain10predpredbrainbrain4expexplung and brainlung and brain5predpredotherother9predpredlung and brainlung and brain19predpredlung and brainlung and brain16predpredlung and brainlung and brain2predpredlung and brainlung and brain1predpredlung and brainlung and brain8predpredlung and brainlung and brain5predpredlung and brainlung and brain11predpredlung and brainlung and brain15expexplunglung2predpredbrainbrain4predpredlung and brainlung and brain26predpredbrainbrain32predpredlunglung15predpredlung and brainlung and brain1predpredbrainbrain9predpredlung and 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