Progress

Technical launch date: November 1, 2007;       Official launch date: November 5, 2007.

  1. January 2008 update
  2. May 2008 update
  3. October 2008 update
  4. April 2009 update
  5. October 2009 update
  6. March 2010 update
  7. October 2010 update
  8. March 2011 update
  9. September 2011 update


Thank you for your continued contribution to our HCC project. In addition to the update listed below, you can learn more about our Cancer Gene Encyclopedia project at the CGEP web site.

We have recently released two exciting portals:

The main publication from WCG work:

  1. Kotseruba, Y., Cumbaa, C. A., Jurisica, I. High‐throughput protein crystallization on the World Community Grid and the GPU. J Physics: Conference Series, High Performance Computing Symposium (HPCS 2011: HPC in Medical Science), 2011. In press.

A few recent exicting cancer-related publications from our group:

  1. Fortney, K., Morgen, E. K., Kotlyar, M., Jurisica, I. In silico drug screen in mouse liver identifies candidate calorie restriction mimetics. Rejuvenation Res, 2011. In press.
  2. Hakem, A., Bohgaki, M., Lemmers, B., Tai, E., Salmena, L., Matysiak-Zablocki, E., López Bähr, W. I., Karaskova, J., Boutros, P., Sheng, Y., Arrowsmith, C., Chesi, M., Bergsagel, L., Perez-Ordonez, B., Squire, J., Jurisica, I., Penn, L., Sanchez, O., Benchimol, S., Hakem, R. PIRH2, a novel tumour suppressor that negatively regulates c-Myc protein stability, PLoS Genetics, 2011. In press.
  3. A gene signature in histologically normal surgical margins is predictive of oral carcinoma recurrence. Reis, P.P., Waldron, L., Perez-Ordonez, B., Pintilie, M., Natalie Galloni, N., Xuan, Y., Cervigne, N.K., Warner, G.C., Makitie, A.A., Simpson, C., Goldstein, D., Brown, D., Gilbert, R., Gullane, P., Irish, J., Jurisica, I., and Kamel-Reid, S., BMC Cancer, 2011. In press.
  4. Liu, X, Fernandes, R., Gertsenstein. M., Perumalsamy, A., Lai, I., Chi, M., Moley, K. H., Greenblatt, E., Jurisica, I., Casper, R.F., Sun, Y., Jurisicova, A. Automated microinjection of recombinant BCL-X into mouse zygotes enhances embryo development, PLoS One, 6(7): e21687, 2011.
  5. Eppert, K., Takenaka, K., Lechman, E.R., Waldron, L., Nilsson, B., van Galen, P., Metzeler, K., Poeppl, A., Ling, V., Beyene, J., Canty, A.J., Danska, J.S., Bohlander, S.K., Buske, C., Minden, M.D., Golub, T.R., Jurisica, I., Ebert, B.L., Dick, J.E. Stem Cell Gene Expression Programs Influence Clinical Outcome in Human Leukemia, Nat Medicine, 14(8): 822–827, 2011.
  6. Notta, F., Doulatov, S., Laurenti, E., Poeppl, A., Jurisica, I. and Dick, J.E. Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment, Science, 333, 218—221, 2011.
  7. Djebbari, A., Ali, M., Otasek, D., Kotlyar. M., Fortney, K., Wong, S., Hrvojic, A. and Jurisica, I. NAViGaTOR: Scalable and Interactive Navigation and Analysis of Large Graphs. Internet Mathematics, 7(4), 2011. In press.
  8. Yan, R., Boutros, P.C., Jurisica, I. A tree-based approach for motif discovery and sequence classification, Bioinformatics, 27(15): 2054-61, 2011.
  9. Osei-Kumah, A., R. Smith, I. Jurisica, I. Caniggia, and V.L. Clifton, Sex-specific differences in placental global gene expression in pregnancies complicated by asthma. Placenta, 32(8): 570-8, 2011.
  10. Reis, P.P., L. Waldron, R.S. Goswami, W. Xu, Y. Xuan, B. Perez-Ordonez, P. Gullane, J. Irish, I. Jurisica, and S. Kamel-Reid, mRNA transcript quantification in archival samples using multiplexed, color-coded probes. BMC Biotechnology, 11:46, 2011.
  11. Yakhini, Z and Jurisica, I. Cancer computational biology, BMC Bioinf. 12(1): 120, 2011. (editorial)
  12. Fortney, K., and Jurisica, I. Integrative computational biology for cancer research. Human Genetics, 130(4): 465-481, 2011. (peer-reviewed review)
  13. Elschenbroich, S., Ignatchenko, V., Clarke, B., Kalloger, S., Boutros, P., Gramolini, A., Shaw, P., Jurisica, I., Kislinger, T. In-depth proteomics of ovarian cancer ascites: Combiningshotgun proteomics and selected reaction monitoring mass spectrometry. J Proteome Res, 10(5):2286-2289 , 2011.
 

Further details about the September 2011 update