4333 0.0103440759589067 Uncharacterized protein C20orf194 11780052 15489334 17974005 18669648 21683323 22085962 NA CT194 -1 Uncharacterized protein C20orf194 gene 1291 0.182533419955059 P - Translation Golgi apparatus IDA ribonucleoprotein complex IEA nucleus IDA RNA processing IEA regulation of translation IEA nucleotide binding IEA RNA binding IEA La-related protein 6; Acheron; Achn; La ribonucleoprotein domain family member 6 14702039 15489334 16572171 17383118 17974005 20603131 21746880 22190748 NA LARP6 -1 La-related protein 6 Acheron Achn La ribonucleoprotein domain family member 6 gene 6095 0.126227128319971 ACACB M - Other Metabolism mitochondrion IEA membrane IEA cytosol TAS endomembrane system IEA energy reserve metabolic process TAS positive regulation of cellular metabolic process TAS protein homotetramerization IDA carnitine shuttle TAS fatty acid biosynthetic process IEA regulation of fatty acid oxidation TAS acetyl-CoA metabolic process IDA cellular lipid metabolic process TAS biotin carboxylase activity IEA acetyl-CoA carboxylase activity IDA ATP binding IEA metal ion binding IEA Acetyl-CoA carboxylase 2; 6.4.1.2; ACC-beta; Biotin carboxylase; 6.3.4.14 12488245 16541075 16854592 17876819 18669648 18772397 20952656 8670171 9099716 NA ACACB -1 Acetyl-CoA carboxylase 2 6.4.1.2 ACC-beta Biotin carboxylase 6.3.4.14 gene 39037 0.0222487677836032 CTIF P - Translation perinuclear region IDA mRNA catabolic process, nonsense-mediated decay IMP regulation of translational initiation IMP RNA binding IEA DNA binding IEA CBP80/20-dependent translation initiation factor 14702039 15489334 16177791 16959974 18088087 18669648 19648179 19690332 21269460 9455477 NA CTIF -1 CBP80/20-dependent translation initiation factor gene 1291 0.0717638596053337 PLXNA3 C - Cellular Fate and Organization intracellular IEA plasma membrane TAS integral to membrane IEA hippocampus development IEA axon guidance TAS positive regulation of cytoskeleton organization and biogenesis IEA negative chemotaxis IEA negative regulation of axon extension involved in axon guidance IEA pyramidal neuron development IEA semaphorin receptor activity IEA transmembrane receptor activity NAS Plexin-A3; Plexin-4; Semaphorin receptor SEX; Precursor 15772651 20138877 8570614 NA PLXA3 1 Plexin-A3 Plexin-4 Semaphorin receptor SEX Precursor gene 3861 0.00414069547142654 FGF2 D - Genome Maintenance nucleus IEA extracellular space TAS cytosol IEA insulin receptor signaling pathway TAS negative regulation of cell growth IEA ureteric bud branching IDA negative regulation of cell proliferation IEA lung development IEA cell migration during sprouting angiogenesis IDA positive regulation of granule cell precursor proliferation IEA positive regulation of cell fate specification IDA Ras protein signal transduction TAS induction of an organ IEA embryonic morphogenesis TAS stem cell development IEA response to axon injury IEA activation of MAPK activity TAS activation of MAPKK activity IEA positive regulation of phosphoinositide 3-kinase activity IDA positive regulation of transcription from RNA polymerase II promoter IDA regulation of cell cycle IEA organ morphogenesis TAS positive regulation of cell division IEA release of sequestered calcium ion into cytosol IDA phosphatidylinositol biosynthetic process IDA apoptosis IEA nuclear translocation of MAPK IEA positive regulation of angiogenesis IDA nervous system development TAS positive regulation of osteoblast differentiation IEA positive regulation of blood vessel endothelial cell migration IDA positive regulation of endothelial cell proliferation IMP substantia nigra development IEA fibroblast growth factor receptor signaling pathway IDA wound healing TAS C21-steroid hormone biosynthetic process IEA glial cell differentiation IEA hyaluronan catabolic process IDA negative regulation of transcription, DNA-dependent IEA negative regulation of blood vessel endothelial cell migration IDA regulation of retinal programmed cell death IEA ligand-dependent nuclear receptor transcription coactivator activity IDA cytokine activity IDA growth factor activity IDA heparin binding IEA chemoattractant activity IDA Fibroblast growth factor 2; FGF-2; Basic fibroblast growth factor; bFGF; Heparin-binding growth factor 2; HBGF-2; Precursor 10358027 11390973 11509569 11964394 1417798 15815621 15863030 16257968 1702556 1707542 1721615 1769963 1785797 1849658 1885605 19054851 20094046 20230531 22321063 2435284 2435575 2538817 3472745 3579930 3732516 3780670 3964259 7691311 8564983 8663044 8885834 NA FGF2 -1 Fibroblast growth factor 2 FGF-2 Basic fibroblast growth factor bFGF Heparin-binding growth factor 2 HBGF-2 Precursor gene 1291 0.201795580665838 PDZRN3 F - Protein Fate neuromuscular junction IEA neuromuscular junction development IEA ubiquitin-protein ligase activity ISS zinc ion binding IEA E3 ubiquitin-protein ligase PDZRN3; 6.3.2.-; Ligand of Numb protein X 3; PDZ domain-containing RING finger protein 3; Semaphorin cytoplasmic domain-associated protein 3; Protein SEMACAP3 10470851 14702039 15010864 15305371 15489334 17118964 17974005 NA PZRN3 -1 E3 ubiquitin-protein ligase PDZRN3 6.3.2.- Ligand of Numb protein X 3 PDZ domain-containing RING finger protein 3 Semaphorin cytoplasmic domain-associated protein 3 Protein SEMACAP3 gene 1291 0.0717638596053337 LRIF1 T - Transcription nucleus IDA nuclear matrix IEA regulation of transcription, DNA-dependent IEA transcription, DNA-dependent IEA Ligand-dependent nuclear receptor-interacting factor 1; Receptor-interacting factor 1 14702039 15489334 16710414 17455211 17974005 18669648 18691976 20068231 NA LRIF1 1 Ligand-dependent nuclear receptor-interacting factor 1 Receptor-interacting factor 1 gene 2835 0.0413570303508753 SMG7 C - Cellular Fate and Organization nucleus IDA intermediate filament cytoskeleton IDA cytosol TAS regulation of dephosphorylation TAS mRNA export from nucleus TAS mRNA catabolic process, nonsense-mediated decay TAS protein phosphatase 2A binding IDA Protein SMG7; EST1-like protein C; SMG-7 homolog; hSMG-7 12168954 14636577 15489334 15546618 15721257 16710414 17081983 18669648 18691976 19690332 21269460 21406692 9039502 NA SMG7 1 Protein SMG7 EST1-like protein C SMG-7 homolog hSMG-7 gene 2476 0.0035102842708369 SLIT2 C - Cellular Fate and Organization cytoplasm IDA plasma membrane TAS cell surface IDA extracellular space IDA metanephros development IEA retinal ganglion cell axon guidance IDA ureteric bud development IMP corticospinal neuron axon guidance through the spinal cord IMP negative regulation of cell growth IMP positive regulation of apoptosis IMP negative regulation of cell proliferation IEA negative regulation of small GTPase mediated signal transduction IDA cell migration during sprouting angiogenesis IMP axon extension involved in axon guidance IDA induction of negative chemotaxis IDA embryonic development (sensu Mammalia) IEA chemorepulsion involved in postnatal olfactory bulb interneuron migration IDA response to cortisol stimulus IEP cell-cell adhesion IEA motor axon guidance IDA negative regulation of actin filament polymerization IDA negative regulation of protein amino acid phosphorylation IDA branching morphogenesis of a tube IDA positive regulation of axonogenesis TAS negative regulation of vascular permeability IDA chemorepellant activity IEA laminin-1 binding IDA calcium ion binding NAS GTPase inhibitor activity IDA heparin binding IDA protein homodimerization activity IDA Slit homolog 2 protein; Slit-2; Slit homolog 2 protein N-product; Slit homolog 2 protein C-product; Precursor 10102268 10349621 10864954 10975526 11222645 11239147 11309622 11404413 12200164 15489334 17704564 17848514 19498462 9813312 NA SLIT2 -1 Slit homolog 2 protein Slit-2 Slit homolog 2 protein N-product Slit homolog 2 protein C-product Precursor gene 1291 2.45778095684738E-4 SMG5 C - Cellular Fate and Organization nucleus IDA cytosol TAS regulation of dephosphorylation IMP mRNA export from nucleus TAS mRNA catabolic process, nonsense-mediated decay TAS protein phosphatase 2A binding IDA Protein SMG5; EST1-like protein B; LPTS-RP1; LPTS-interacting protein; SMG-5 homolog; hSMG-5 10470851 12168954 12699629 14636577 15489334 15546618 16710414 17053788 17974005 NA SMG5 1 Protein SMG5 EST1-like protein B LPTS-RP1 LPTS-interacting protein SMG-5 homolog hSMG-5 gene 1291 0.0914604721306057 MORF4L2 D - Genome Maintenance nucleolus IDA DNA repair IEA positive regulation of transcription from RNA polymerase II promoter IEA positive regulation of striated muscle cell differentiation IEA regulation of cell growth NAS transcription, DNA-dependent IEA chromatin modification IEA Mortality factor 4-like protein 2; MORF-related gene X protein; Protein MSL3-2; Transcription factor-like protein MRGX 12391155 12963728 14506250 14702039 15489334 15772651 18669648 21269460 7584026 9891081 NA MO4L2 1 Mortality factor 4-like protein 2 MORF-related gene X protein Protein MSL3-2 Transcription factor-like protein MRGX gene 8822 1.0 D - Genome Maintenance nucleus IDA G2/M-specific transcription in mitotic cell cycle IMP G1/S-specific transcription in mitotic cell cycle IMP sequence-specific DNA binding IEA heme binding NAS Transcription regulator protein BACH1; BTB and CNC homolog 1; HA2303 10830953 15489334 16964243 18669648 9479503 9544839 NA BACH1 0 Transcription regulator protein BACH1 BTB and CNC homolog 1 HA2303 TF 1291 0.229882269744199 JAM3 C - Cellular Fate and Organization desmosome IDA Schmidt-Lanterman cleft IEA plasma membrane TAS tight junction IEA integral to membrane IEA extracellular space IDA adaptive immune response IEA neutrophil homeostasis IEA cell-matrix adhesion IEA leukocyte migration during inflammatory response IEA blood coagulation TAS myelination IEA spermatid development IEA establishment of cell polarity IEA angiogenesis IDA myeloid progenitor cell differentiation IEA leukocyte migration TAS Junctional adhesion molecule C; JAM-C; JAM-2; Junctional adhesion molecule 3; JAM-3; Precursor 11590146 11739175 11944976 12208882 12810109 12975309 14702039 15194813 15340161 15489334 15994945 16554811 19349973 20592283 21109224 21269460 NA JAM3 -1 Junctional adhesion molecule C JAM-C JAM-2 Junctional adhesion molecule 3 JAM-3 Precursor gene 5585 0.050860863154566 RASSF2 D - Genome Maintenance cytoplasm IEA nucleus IEA signal transduction IEA cell cycle IEA Ras association domain-containing protein 2 11780052 12732644 14702039 15489334 15569673 16012945 16959974 17974005 19525978 21269460 8724849 NA RASF2 -1 Ras association domain-containing protein 2 gene 1805 2.85397691809248E-4 PALMD N - Not Matched cytoplasm IEA dendritic spine IEA membrane IEA regulation of cell shape IEA Palmdelphin; Paralemnin-like protein 11478809 11707320 14702039 15489334 17081983 18220336 18669648 20068231 NA PALMD -1 Palmdelphin Paralemnin-like protein gene 1291 0.0079629809758649 D - Genome Maintenance Golgi cis face IEA cytoplasm TAS nucleus TAS spermatogenesis IEA protein serine/threonine kinase activity TAS zinc ion binding IEA ATP binding IEA LIM domain kinase 2; LIMK-2; 2.7.11.1 10436159 10591208 11018042 11230166 11340065 14702039 15461802 15489334 17053785 17344846 18669648 18691976 19369195 8537403 8954941 NA LIMK2 1 LIM domain kinase 2 LIMK-2 2.7.11.1 gene 8243 0.00417503990195944 TAL1 D - Genome Maintenance transcription factor complex IDA nuclear chromatin IDA positive regulation of chromatin assembly or disassembly IMP negative regulation of transcription from RNA polymerase II promoter IEA angiogenesis IEA spinal cord association neuron differentiation IEA positive regulation of progression through mitotic cell cycle IMP astrocyte fate commitment IEA positive regulation of protein complex assembly IDA erythrocyte maturation IEA cell fate commitment ISS positive regulation of erythrocyte differentiation IDA positive regulation of transcription from RNA polymerase II promoter IDA megakaryocyte differentiation IEP regulation of cell proliferation IEA erythrocyte differentiation IMP locomotory behavior IEA positive regulation of cell division IMP embryonic hemopoiesis ISS basophil differentiation IEP platelet formation IEA transcription factor activity IDA chromatin binding IDA T-cell acute lymphocytic leukemia protein 1; TAL-1; Class A basic helix-loop-helix protein 17; bHLHa17; Stem cell protein; T-cell leukemia/lymphoma protein 5 1396592 16710414 19690332 2230650 2247063 2303035 2602361 8437851 NA TAL1 -1 T-cell acute lymphocytic leukemia protein 1 TAL-1 Class A basic helix-loop-helix protein 17 bHLHa17 Stem cell protein T-cell leukemia/lymphoma protein 5 TF 1291 0.0313018543002082 TFB2M T - Transcription mitochondrial nucleoid IDA transcription initiation from mitochondrial promoter IDA positive regulation of transcription, DNA-dependent IDA transcription cofactor activity IDA rRNA (adenine-N6,N6-)-dimethyltransferase activity IEA Dimethyladenosine transferase 2, mitochondrial; 2.1.1.-; Hepatitis C virus NS5A-transactivated protein 5; HCV NS5A-transactivated protein 5; Mitochondrial 12S rRNA dimethylase 2; Mitochondrial transcription factor B2; h-mtTFB; h-mtTFB2; hTFB2M; mtTFB2; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2; Precursor 12068295 12897151 14702039 15489334 15526033 15684387 16710414 17031457 20410300 21269460 NA TFB2M 1 Dimethyladenosine transferase 2, mitochondrial 2.1.1.- Hepatitis C virus NS5A-transactivated protein 5 HCV NS5A-transactivated protein 5 Mitochondrial 12S rRNA dimethylase 2 Mitochondrial transcription factor B2 h-mtTFB h-mtTFB2 hTFB2M mtTFB2 S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2 Precursor gene 1291 0.0051926145583678 TMEM248 N - Not Matched integral to membrane IEA Transmembrane protein 248 12690205 14702039 15489334 NA TM248 1 Transmembrane protein 248 gene 1291 3.6767342038056E-4 NUF2 D - Genome Maintenance condensed chromosome kinetochore IEA nucleus IEA Ndc80 complex IDA cytosol TAS mitotic prometaphase TAS chromosome segregation NAS cell division IEA Kinetochore protein Nuf2; hNuf2; hNuf2R; hsNuf2; Cell division cycle-associated protein 1 11266451 11685532 12438418 14602875 14654001 14699129 14702039 15062103 15235793 15239953 15489334 15548592 15961401 16710414 17535814 18669648 21269460 NA NUF2 1 Kinetochore protein Nuf2 hNuf2 hNuf2R hsNuf2 Cell division cycle-associated protein 1 gene 3578 0.00616644798288088 SSR3 P - Translation translocon complex IEA integral to endoplasmic reticulum membrane IEA SRP-dependent cotranslational protein targeting to membrane TAS translation TAS Translocon-associated protein subunit gamma; TRAP-gamma; Signal sequence receptor subunit gamma; SSR-gamma 14702039 15489334 18669648 18691976 21269460 NA SSRG 1 Translocon-associated protein subunit gamma TRAP-gamma Signal sequence receptor subunit gamma SSR-gamma gene 1291 0.00190723864225319 SSR2 P - Translation endoplasmic reticulum TAS endoplasmic reticulum membrane IEA integral to membrane TAS SRP-dependent cotranslational protein targeting to membrane TAS translation TAS Translocon-associated protein subunit beta; TRAP-beta; Signal sequence receptor subunit beta; SSR-beta; Precursor 12754519 14702039 15489334 16710414 18724357 19159218 7789174 8286409 NA SSRB 1 Translocon-associated protein subunit beta TRAP-beta Signal sequence receptor subunit beta SSR-beta Precursor gene 1291 6.17614106217859E-5 STYXL1 C - Cellular Fate and Organization phosphoprotein phosphatase activity IEA Serine/threonine/tyrosine-interacting-like protein 1; Dual specificity phosphatase inhibitor MK-STYX; Dual specificity protein phosphatase 24; Map kinase phosphatase-like protein MK-STYX 12853948 15489334 9757831 NA STYL1 1 Serine/threonine/tyrosine-interacting-like protein 1 Dual specificity phosphatase inhibitor MK-STYX Dual specificity protein phosphatase 24 Map kinase phosphatase-like protein MK-STYX gene 1291 0.0079629809758649 SSR1 C - Cellular Fate and Organization endoplasmic reticulum membrane TAS integral to membrane TAS positive regulation of cell proliferation TAS SRP-dependent cotranslational protein targeting to membrane TAS unfolded protein response, activation of signaling protein activity TAS translation TAS Translocon-associated protein subunit alpha; TRAP-alpha; Signal sequence receptor subunit alpha; SSR-alpha; Precursor 10437777 12754519 14574404 14702039 15489334 1557127 16303743 17081983 18669648 18691976 19159218 19369195 19690332 20068231 21269460 22314232 8050590 NA SSRA 1 Translocon-associated protein subunit alpha TRAP-alpha Signal sequence receptor subunit alpha SSR-alpha Precursor gene 27691 8.82086531100235E-7 PALLD C - Cellular Fate and Organization Z disc IEA actin filament IDA nucleus IDA ruffle IEA focal adhesion IEA lamellipodium IEA cytoskeleton organization and biogenesis NAS muscle alpha-actinin binding TAS Palladin; SIH002; Sarcoma antigen NY-SAR-77 10231032 10810093 11598191 12601173 14702039 15147863 15489334 15815621 16125169 16175505 16367745 16754980 16794588 16964243 17081983 17194196 17322171 17415588 17455999 17537434 17974005 18669648 19690332 20068231 20471940 21269460 21406692 NA PALLD -1 Palladin SIH002 Sarcoma antigen NY-SAR-77 gene 1861 0.00458201074186734 ZNF385B N - Not Matched nucleus IEA zinc ion binding IEA nucleic acid binding IEA Zinc finger protein 385B; Zinc finger protein 533 14702039 15489334 NA Z385B -1 Zinc finger protein 385B Zinc finger protein 533 gene 1291 0.0651197801949104 GPR125 A - Transport and Sensing integral to membrane TAS external side of plasma membrane IEA neuropeptide signaling pathway IEA G-protein coupled receptor activity TAS Probable G-protein coupled receptor 125; Precursor 12565841 12975309 15021905 15489334 15815621 NA GP125 1 Probable G-protein coupled receptor 125 Precursor gene 1291 0.148472992584061 FAM199X Protein FAM199X 15489334 15772651 18669648 NA F199X 1 Protein FAM199X gene 3453 0.145385885608534 FGD6 C - Cellular Fate and Organization Golgi apparatus ISS cytoskeleton IEA ruffle ISS lamellipodium ISS actin cytoskeleton organization and biogenesis ISS regulation of cell shape ISS filopodium formation ISS regulation of Cdc42 GTPase activity ISS guanyl-nucleotide exchange factor activity ISS phospholipid binding IEA small GTPase binding ISS Rho guanyl-nucleotide exchange factor activity IEA metal ion binding IEA FYVE, RhoGEF and PH domain-containing protein 6; Zinc finger FYVE domain-containing protein 24 10718198 14702039 15489334 17974005 18669648 20068231 21406692 NA FGD6 1 FYVE, RhoGEF and PH domain-containing protein 6 Zinc finger FYVE domain-containing protein 24 gene 1291 0.110735761722654 FGD5 C - Cellular Fate and Organization Golgi apparatus ISS endoplasmic reticulum IEA cytoskeleton IEA ruffle ISS early endosome IEA lamellipodium ISS actin cytoskeleton organization and biogenesis ISS regulation of cell shape ISS filopodium formation ISS regulation of Cdc42 GTPase activity ISS guanyl-nucleotide exchange factor activity ISS phospholipid binding IEA small GTPase binding ISS Rho guanyl-nucleotide exchange factor activity IEA metal ion binding IEA FYVE, RhoGEF and PH domain-containing protein 5; Zinc finger FYVE domain-containing protein 23 10737800 14702039 15489334 16641997 17974005 22328776 NA FGD5 -1 FYVE, RhoGEF and PH domain-containing protein 5 Zinc finger FYVE domain-containing protein 23 gene 39331 1.53722606257415E-5 DIXDC1 C - Cellular Fate and Organization cell soma IBA nerve terminal IBA focal adhesion IEA cell cortex IBA cytosol IDA regulation of JNK cascade IBA cerebellar cortex development IBA eye development (sensu Vertebrata) IBA forebrain development IBA positive regulation of axonogenesis IBA Wnt receptor signaling pathway IEA gamma-tubulin binding IDA mitogen-activated protein kinase kinase kinase binding IBA signal transducer activity IEA Dixin; Coiled-coil protein DIX1; Coiled-coil-DIX1; DIX domain-containing protein 1 11214970 14702039 15262978 15489334 16814745 18669648 19375513 20068231 20085589 20213681 21189423 NA DIXC1 -1 Dixin Coiled-coil protein DIX1 Coiled-coil-DIX1 DIX domain-containing protein 1 gene 1291 0.117179770282665 CDH1 C - Cellular Fate and Organization Schmidt-Lanterman cleft IEA Golgi trans face IMP perinuclear region IDA Golgi apparatus IEA cell surface IEA aggresome IDA apical part of cell IEA catenin complex IDA actin cytoskeleton IDA lateral plasma membrane IDA apical junction complex IDA basolateral plasma membrane IEA cell-cell adherens junction IDA lateral loop IEA internal side of plasma membrane IDA nerve terminal IEA integral to membrane IDA focal adhesion IDA endosome IEA negative regulation of cell-cell adhesion IMP sensory perception of sound IEA response to drug IEA pituitary gland development IEA response to toxin IEA trophectodermal cell differentiation IEA synaptogenesis IEA positive regulation of transcription factor import into nucleus IDA cell structure disassembly during apoptosis TAS neurite development IEA regulation of caspase activity IEA regulation of immune response TAS protein homooligomerization IEA positive regulation of transcription, DNA-dependent IDA homophilic cell adhesion NAS protein metabolic process IEA beta-catenin binding IDA calcium ion binding IEA cell adhesion molecule binding NAS Cadherin-1; CAM 120/80; Epithelial cadherin; E-cadherin; Uvomorulin; CD324; E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3; Precursor 10319582 10597309 10896919 11076937 11226248 11562785 11705864 11856755 11953314 11968083 12216071 12526809 12588804 14595118 14699157 14702039 15689490 16126725 16417575 17224074 17261850 17850815 17893710 18093941 18491227 19604491 20066110 20116244 20432435 21269460 21283129 22252131 22770219 2349235 3263290 7543680 7601454 7961105 7982500 8033105 8075649 8093045 8127895 8185635 8459805 8797891 8985087 9045944 9537325 9744472 NA CADH1 1 Cadherin-1 CAM 120/80 Epithelial cadherin E-cadherin Uvomorulin CD324 E-Cad/CTF1 E-Cad/CTF2 E-Cad/CTF3 Precursor gene 27398 0.00150790326259068 KANK2 C - Cellular Fate and Organization mitochondrion IDA negative regulation of programmed cell death IDA negative regulation of cell proliferation IDA apoptosis IEA negative regulation of transcription from RNA polymerase II promoter IDA transcription, DNA-dependent IEA KN motif and ankyrin repeat domain-containing protein 2; Ankyrin repeat domain-containing protein 25; Matrix-remodeling-associated protein 3; SRC-1-interacting protein; SIP; SRC-interacting protein; SRC1-interacting protein 10819331 14702039 15489334 17081983 17476305 17525332 17996375 18669648 19369195 20068231 20720434 22371500 NA KANK2 -1 KN motif and ankyrin repeat domain-containing protein 2 Ankyrin repeat domain-containing protein 25 Matrix-remodeling-associated protein 3 SRC-1-interacting protein SIP SRC-interacting protein SRC1-interacting protein gene 1514 0.00298885354381607 C - Cellular Fate and Organization mitochondrion IEA cell surface IDA integral to plasma membrane IDA cell soma IEA nucleus IEA extracellular space IDA extrinsic to membrane IEA tyrosine phosphorylation of JAK2 protein ISS isoleucine metabolic process ISS taurine metabolic process ISS allantoin metabolic process ISS positive regulation of cell differentiation IEA cytokine and chemokine mediated signaling pathway IEA positive regulation of tyrosine phosphorylation of Stat5 protein ISS response to food IEA receptor internalization IDA activation of MAPK activity ISS citrate metabolic process ISS succinate metabolic process ISS 2-oxoglutarate metabolic process ISS fatty acid metabolic process ISS multicellular organismal metabolic process IMP valine metabolic process ISS positive regulation of body size IMP response to estradiol stimulus IDA positive regulation of tyrosine phosphorylation of Stat3 protein ISS oxaloacetate metabolic process ISS response to glucocorticoid stimulus IEA response to cycloheximide IDA response to morphine IEA creatinine metabolic process ISS endocytosis IEA hormone-mediated signaling IEA creatine metabolic process ISS insulin-like growth factor receptor signaling pathway IMP protein kinase binding ISS growth hormone receptor activity IEA peptide hormone binding IPI protein homodimerization activity IDA Growth hormone receptor; GH receptor; Somatotropin receptor; Growth hormone-binding protein; GH-binding protein; GHBP; Serum-binding protein; Precursor 10391209 10764769 10870033 11785980 12910492 14678285 1549776 1569971 2406245 2779634 2813379 2825030 7565946 8137822 8360189 8421103 8450064 8504296 8855247 8943276 9024232 9058373 9360546 9661642 9814495 9851797 NA GHR -1 Growth hormone receptor GH receptor Somatotropin receptor Growth hormone-binding protein GH-binding protein GHBP Serum-binding protein Precursor gene 1291 0.0347288524571649 P - Translation mitochondrial ribosome NAS translation NAS structural constituent of ribosome NAS 39S ribosomal protein L9, mitochondrial; L9mt; MRP-L9; Precursor 11279069 14702039 15489334 16710414 21269460 NA RM09 1 39S ribosomal protein L9, mitochondrial L9mt MRP-L9 Precursor gene 1291 0.0467346765150697 FCHSD2 FCH and double SH3 domains protein 2; Carom; SH3 multiple domains protein 3 14627983 14702039 15067381 15489334 16554811 17974005 9872452 NA FCSD2 -1 FCH and double SH3 domains protein 2 Carom SH3 multiple domains protein 3 gene 1291 0.17273753523313 SLC46A2 N - Not Matched plasma membrane IEA cell surface IEA integral to membrane NAS symporter activity NAS Thymic stromal cotransporter homolog; Solute carrier family 46 member 2 10978518 14702039 15164053 15489334 NA TSCOT -1 Thymic stromal cotransporter homolog Solute carrier family 46 member 2 gene 1291 0.0882021116002911 TRIP13 D - Genome Maintenance nucleus TAS male germ cell nucleus IEA female meiosis I IEA pachytene IEA transcription from RNA polymerase II promoter TAS oogenesis ISS spermatid development IEA oocyte maturation IEA spermatogenesis ISS synaptonemal complex formation ISS male meiosis I IEA double-strand break repair ISS meiotic recombination ISS transcription cofactor activity TAS nucleoside-triphosphatase activity IEA ATP binding NAS Pachytene checkpoint protein 2 homolog; Human papillomavirus type 16 E1 protein-binding protein; 16E1-BP; HPV16 E1 protein-binding protein; Thyroid hormone receptor interactor 13; Thyroid receptor-interacting protein 13; TR-interacting protein 13; TRIP-13 15489334 15592455 17081983 18691976 20068231 21269460 7776974 9223484 NA PCH2 1 Pachytene checkpoint protein 2 homolog Human papillomavirus type 16 E1 protein-binding protein 16E1-BP HPV16 E1 protein-binding protein Thyroid hormone receptor interactor 13 Thyroid receptor-interacting protein 13 TR-interacting protein 13 TRIP-13 gene 1291 0.122062164231375 BCHE A - Transport and Sensing membrane IEA nuclear envelope lumen IEA endoplasmic reticulum lumen IBA extracellular space IBA cocaine metabolic process TAS choline metabolic process IBA synaptic transmission, cholinergic IBA carboxylesterase activity IBA acetylcholinesterase activity ISS beta-amyloid binding NAS enzyme binding NAS Cholinesterase; 3.1.1.8; Acylcholine acylhydrolase; Butyrylcholine esterase; Choline esterase II; Pseudocholinesterase; Precursor 10404729 11928765 12869558 12881446 1306123 1349196 1415224 14702039 14760718 15489334 15563885 15667209 1611188 16335952 16788378 17355286 17768338 18075469 18975951 19159218 19368529 19452557 19542320 22444575 2322535 2915989 3035536 3115973 3477799 3542989 7634491 8554068 8680411 9110359 9191541 9388484 9543549 9694584 NA CHLE -1 Cholinesterase 3.1.1.8 Acylcholine acylhydrolase Butyrylcholine esterase Choline esterase II Pseudocholinesterase Precursor gene 4445 5.24688357300859E-4 PAFAH1B1 D - Genome Maintenance astral microtubule IDA perinuclear region ISS centrosome IDA kinesin complex IEA nuclear membrane IEA microtubule associated complex IDA nuclear envelope IDA motile primary cilium ISS vesicle IEA cytosol ISS growth cone IEA cell soma IEA kinetochore IDA leading edge IEA cell cortex IDA mitotic prometaphase TAS acrosome formation ISS adult locomotory behavior IMP retrograde axon cargo transport ISS actin cytoskeleton organization and biogenesis ISS protein secretion IEA nuclear migration IEA stem cell division IEA positive regulation of axon extension IEA establishment of mitotic spindle orientation IMP synaptic transmission ISS neuroblast proliferation ISS establishment of centrosome localization IEA negative regulation of JNK cascade IEA vesicle transport along microtubule ISS positive regulation of cytokine and chemokine mediated signaling pathway IEA G2/M transition of mitotic cell cycle TAS microtubule organizing center organization and biogenesis IMP regulation of balance IMP learning and/or memory ISS regulation of Rho GTPase activity ISS cerebral cortex neuron differentiation IEA platelet activating factor metabolic process ISS corpus callosum morphogenesis IMP ameboidal cell migration IEA layer formation in the cerebral cortex ISS brain morphogenesis IMP lipid catabolic process IEA hippocampus development ISS positive regulation of progression through mitotic cell cycle IEA neuron migration IMP nuclear envelope disassembly IEA microtubule binding ISS phosphoprotein binding ISS dynein binding IDA phospholipase binding ISS heparin binding ISS protein homodimerization activity ISS Platelet-activating factor acetylhydrolase IB subunit alpha; Lissencephaly-1 protein; LIS-1; PAF acetylhydrolase 45 kDa subunit; PAF-AH 45 kDa subunit; PAF-AH alpha; PAFAH alpha 10441340 11001923 11163258 11502906 11889140 11940666 12556484 14581661 14702039 14962739 14970193 15007136 15173193 15489334 17974005 19608861 21269460 8355785 9063735 NA LIS1 -1 Platelet-activating factor acetylhydrolase IB subunit alpha Lissencephaly-1 protein LIS-1 PAF acetylhydrolase 45 kDa subunit PAF-AH 45 kDa subunit PAF-AH alpha PAFAH alpha gene 1291 0.201795580665838 AOC3 C - Cellular Fate and Organization plasma membrane IDA cell surface IDA integral to membrane IDA inflammatory response TAS amine metabolic process IDA cell adhesion IDA response to antibiotic IDA amine oxidase activity IDA cation channel activity IDA quinone binding IDA copper ion binding IDA calcium ion binding IDA protein homodimerization activity TAS Membrane primary amine oxidase; 1.4.3.21; Copper amine oxidase; HPAO; Semicarbazide-sensitive amine oxidase; SSAO; Vascular adhesion protein 1; VAP-1 14585497 14702039 15242332 15489334 16046623 16335952 17400359 19159218 19588076 8972912 9653080 NA AOC3 -1 Membrane primary amine oxidase 1.4.3.21 Copper amine oxidase HPAO Semicarbazide-sensitive amine oxidase SSAO Vascular adhesion protein 1 VAP-1 gene 1291 7.91637519637533E-4 SLC35B2 C - Cellular Fate and Organization Golgi membrane TAS integral to membrane NAS 3'-phosphoadenosine 5'-phosphosulfate transport IDA positive regulation of I-kappaB kinase/NF-kappaB cascade IMP 3'-phosphoadenosine 5'-phosphosulfate transporter activity IDA signal transducer activity IMP Adenosine 3'-phospho 5'-phosphosulfate transporter 1; PAPS transporter 1; Putative MAPK-activating protein PM15; Putative NF-kappa-B-activating protein 48; Solute carrier family 35 member B2 12716889 12761501 14574404 15489334 16303743 18669648 18691976 20068231 21269460 NA S35B2 1 Adenosine 3'-phospho 5'-phosphosulfate transporter 1 PAPS transporter 1 Putative MAPK-activating protein PM15 Putative NF-kappa-B-activating protein 48 Solute carrier family 35 member B2 gene 1291 0.142676365585747 CIRBP P - Translation nucleus IDA nucleoplasm IEA response to cold TAS positive regulation of protein biosynthetic process IDA mRNA stabilization IDA response to UV IDA nucleotide binding IEA mRNA 3'-UTR binding IDA translation repressor activity ISS Cold-inducible RNA-binding protein; A18 hnRNP; Glycine-rich RNA-binding protein CIRP 11574538 15057824 15075239 15489334 16513844 18669648 19690332 21269460 9334257 9434172 NA CIRBP -1 Cold-inducible RNA-binding protein A18 hnRNP Glycine-rich RNA-binding protein CIRP gene 1291 0.0313018543002082 SLC35B1 A - Transport and Sensing endoplasmic reticulum membrane IEA integral to membrane IEA intracellular membrane-bound organelle TAS UDP-galactose transporter activity TAS Solute carrier family 35 member B1; UDP-galactose transporter-related protein 1; UGTrel1; hUGTrel1 15489334 9010752 NA S35B1 1 Solute carrier family 35 member B1 UDP-galactose transporter-related protein 1 UGTrel1 hUGTrel1 gene 1291 0.0021046852814931 EEF1E1 C - Cellular Fate and Organization nucleus ISS cytosol TAS negative regulation of cell proliferation ISS positive regulation of apoptosis ISS positive regulation of DNA damage response, signal transduction by p53 class mediator ISS tRNA aminoacylation for protein translation TAS Eukaryotic translation elongation factor 1 epsilon-1; Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3; Elongation factor p18; Multisynthase complex auxiliary component p18 14574404 15489334 15680327 18343821 19608861 21269460 9653160 NA MCA3 1 Eukaryotic translation elongation factor 1 epsilon-1 Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3 Elongation factor p18 Multisynthase complex auxiliary component p18 gene 4285 0.00503499461286295 N - Not Matched membrane IEA endoplasmic reticulum IDA interstitial matrix IEA peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan IEA glycosaminoglycan binding IEA MAM domain-containing protein 2; MAM domain-containing proteoglycan; Mamcan; Precursor 15164053 15489334 17974005 NA MAMC2 -1 MAM domain-containing protein 2 MAM domain-containing proteoglycan Mamcan Precursor gene 29246 1.97010898273216E-4 N - Not Matched endoplasmic reticulum membrane TAS integral to membrane IEA xenobiotic metabolic process IDA drug metabolic process IDA organic acid metabolic process IDA toxin metabolic process IDA NADP binding IEA dimethylaniline monooxygenase (N-oxide-forming) activity IDA FAD binding IEA Dimethylaniline monooxygenase [N-oxide-forming] 2; 1.14.13.8; Dimethylaniline oxidase 2; FMO 1B1; Pulmonary flavin-containing monooxygenase 2; FMO 2 11042094 12527699 15489334 16710414 18794725 20388717 9804831 NA FMO2 -1 Dimethylaniline monooxygenase [N-oxide-forming] 2 1.14.13.8 Dimethylaniline oxidase 2 FMO 1B1 Pulmonary flavin-containing monooxygenase 2 FMO 2 gene 1291 0.00190723864225319 DAP T - Transcription caspase activation IMP autophagy IEA inhibition of NF-kappaB transcription factor IMP negative regulation of transcription, DNA-dependent IMP Death-associated protein 1; DAP-1 15489334 16602700 17081983 18669648 20068231 20537536 21406692 7828849 NA DAP1 1 Death-associated protein 1 DAP-1 gene 1291 0.0381457414750155 N - Not Matched mitochondrion IEA integral to membrane IEA Transmembrane protein 223 15489334 21269460 NA TM223 1 Transmembrane protein 223 gene 3572 0.00298885354381607 C - Cellular Fate and Organization microvillus IDA basolateral plasma membrane IEA cytoplasm IDA apical plasma membrane IEA plasma membrane IDA nucleolus IDA microvillus membrane IEA apical part of cell IDA uropod IEA filopodium IDA cytoskeleton TAS extrinsic to membrane IEA leukocyte adhesion IEP membrane to membrane docking IEP leukocyte migration IEP structural constituent of cytoskeleton TAS Moesin; Membrane-organizing extension spike protein 10847681 11401550 12387735 12665801 15020681 15489334 15772651 18586956 18669648 1924289 19255442 19608861 19690332 21269460 21549406 9314537 NA MOES -1 Moesin Membrane-organizing extension spike protein gene 13359 0.0118402561230045 ABCG2 M - Other Metabolism plasma membrane TAS integral to membrane TAS iron ion homeostasis TAS urate metabolic process IMP xenobiotic-transporting ATPase activity TAS heme transporter activity TAS ATP binding TAS protein homodimerization activity IDA ATP-binding cassette sub-family G member 2; Breast cancer resistance protein; CDw338; Mitoxantrone resistance-associated protein; Placenta-specific ATP-binding cassette transporter; CD338 11306452 11533706 11590207 12111378 12544509 12958161 14702039 15489334 15618737 15670731 15769853 15807535 15838659 16702730 17686774 18834626 19506252 20368174 22246505 22246507 9850061 9861027 9892175 NA ABCG2 -1 ATP-binding cassette sub-family G member 2 Breast cancer resistance protein CDw338 Mitoxantrone resistance-associated protein Placenta-specific ATP-binding cassette transporter CD338 gene 11531 0.0349947638172555 TACC1 D - Genome Maintenance cytoplasm IDA microtubule organizing center IEA microtubule cytoskeleton IDA nucleus IEA intermediate filament cytoskeleton IDA cell cycle IEA cerebral cortex development IEA interkinetic nuclear migration IEA microtubule cytoskeleton organization and biogenesis IEA neurogenesis IEA cell division IEA Transforming acidic coiled-coil-containing protein 1; Gastric cancer antigen Ga55; Taxin-1 10435627 10470851 11121038 11903063 12087473 12165861 12547166 14603251 14702039 14767476 15064709 15207008 15489334 15592455 17081983 17525332 18669648 19690332 20068231 21269460 21531210 NA TACC1 -1 Transforming acidic coiled-coil-containing protein 1 Gastric cancer antigen Ga55 Taxin-1 gene 7138 2.8377244239639E-4 OSBPL2 A - Transport and Sensing lipid transport IEA cholesterol binding IDA Oxysterol-binding protein-related protein 2; ORP-2; OSBP-related protein 2 11279184 11483621 11735225 11780052 14702039 15489334 21269460 9872452 NA OSBL2 1 Oxysterol-binding protein-related protein 2 ORP-2 OSBP-related protein 2 gene 1470 0.00602036665382763 LYVE1 C - Cellular Fate and Organization integral to plasma membrane TAS cell-matrix adhesion TAS carbohydrate metabolic process TAS transport IEA response to wounding TAS cell motility TAS hyaluronan catabolic process TAS anatomical structure morphogenesis TAS hyaluronic acid binding IEA receptor activity TAS transmembrane receptor activity IEA Lymphatic vessel endothelial hyaluronic acid receptor 1; LYVE-1; Cell surface retention sequence-binding protein 1; CRSBP-1; Extracellular link domain-containing protein 1; Hyaluronic acid receptor; Precursor 10037799 12975309 15489334 16335952 19159218 NA LYVE1 -1 Lymphatic vessel endothelial hyaluronic acid receptor 1 LYVE-1 Cell surface retention sequence-binding protein 1 CRSBP-1 Extracellular link domain-containing protein 1 Hyaluronic acid receptor Precursor gene 11483 0.20829202017642 COL11A1 A - Transport and Sensing collagen type XI IDA endoplasmic reticulum lumen TAS inner ear morphogenesis IEA chondrocyte development IEA ventricular cardiac muscle morphogenesis IEA cartilage condensation IEA collagen fibril organization NAS detection of mechanical stimulus during sensory perception of sound IMP embryonic skeletal morphogenesis IEA proteoglycan metabolic process IEA visual perception IMP extracellular matrix binding NAS protein binding, bridging NAS metal ion binding IEA extracellular matrix structural constituent NAS Collagen alpha-1(XI) chain; Precursor 10486316 15489334 16710414 1690726 16959974 20513134 21035103 3182841 7721876 8872475 NA COBA1 1 Collagen alpha-1(XI) chain Precursor gene 1291 0.0947091236009375 PAICS M - Other Metabolism cytosol TAS purine ribonucleoside monophosphate biosynthetic process TAS purine base biosynthetic process TAS 'de novo' IMP biosynthetic process IEA phosphoribosylaminoimidazolesuccinocarboxamide synthase activity TAS phosphoribosylaminoimidazole carboxylase activity TAS ATP binding IEA Multifunctional protein ADE2; Phosphoribosylaminoimidazole-succinocarboxamide synthase; 6.3.2.6; SAICAR synthetase; Phosphoribosylaminoimidazole carboxylase; 4.1.1.21; AIR carboxylase; AIRC 15489334 15815621 16964243 17224163 17924679 17974005 18669648 18691976 19369195 19608861 19690332 20068231 21269460 21406692 2253271 NA PUR6 1 Multifunctional protein ADE2 Phosphoribosylaminoimidazole-succinocarboxamide synthase 6.3.2.6 SAICAR synthetase Phosphoribosylaminoimidazole carboxylase 4.1.1.21 AIR carboxylase AIRC gene 1291 0.00914305577801058 SLC35A2 A - Transport and Sensing Golgi membrane TAS nucleus IDA integral to membrane IEA galactose metabolic process TAS sugar porter activity IEA UDP-galactose transporter activity TAS UDP-galactose translocator; Solute carrier family 35 member A2; UDP-galactose transporter; UDP-Gal-Tr; UGT 14702039 15489334 15772651 16959974 8128316 8889805 9010752 NA S35A2 1 UDP-galactose translocator Solute carrier family 35 member A2 UDP-galactose transporter UDP-Gal-Tr UGT gene 1291 0.0240272120400372 HSPB8 R - Stress and Defence cytoplasm IDA nucleus IDA cell death IEA response to stress IEA Heat shock protein beta-8; HspB8; Alpha-crystallin C chain; E2-induced gene 1 protein; Protein kinase H11; Small stress protein-like protein HSP22 10833516 11085516 11230166 11342557 11470154 11816564 14702039 15122253 15489334 15498874 15565283 17344846 18220336 18669648 19464326 21269460 22366786 NA HSPB8 -1 Heat shock protein beta-8 HspB8 Alpha-crystallin C chain E2-induced gene 1 protein Protein kinase H11 Small stress protein-like protein HSP22 gene 9740 3.47648848728184E-4 METAP1 P - Translation cytoplasm TAS proteolysis IEA peptidyl-methionine modification TAS regulation of translation TAS N-terminal protein amino acid modification TAS aminopeptidase activity TAS metalloexopeptidase activity TAS metal ion binding IEA Methionine aminopeptidase 1; MAP 1; MetAP 1; 3.4.11.18; Peptidase M 1 14702039 15489334 16274222 16724298 16823043 17114291 21269460 7788527 NA AMPM1 1 Methionine aminopeptidase 1 MAP 1 MetAP 1 3.4.11.18 Peptidase M 1 gene 1291 0.0080442634822031 C - Cellular Fate and Organization nucleus IDA cytosol TAS response to unfolded protein NAS response to heat IEA somatic muscle development IEA enzyme activator activity TAS Heat shock protein beta-2; HspB2; DMPK-binding protein; MKBP 15489334 19464326 8227983 9344664 9490724 NA HSPB2 -1 Heat shock protein beta-2 HspB2 DMPK-binding protein MKBP gene 30415 0.00420834398497903 GAS7 D - Genome Maintenance cytoplasm IEA actin filament IEA ruffle IEA regulation of cell shape IEA neurite morphogenesis IEA actin filament polymerization IEA cell cycle arrest TAS actin filament bundle formation IEA transcription factor activity TAS Growth arrest-specific protein 7; GAS-7 10706619 14702039 15489334 16625196 19690332 9455477 NA GAS7 -1 Growth arrest-specific protein 7 GAS-7 gene 5771 0.0832848332918077 C - Cellular Fate and Organization nuclear chromatin IDA lymphoid progenitor cell differentiation IEA anatomical structure regression IEA negative regulation of transcription from RNA polymerase II promoter TAS induction of apoptosis IEA positive regulation of transcription from RNA polymerase II promoter ISS negative regulation of gene expression, epigenetic IDA erythrocyte differentiation IEA negative regulation of MHC class II biosynthetic process IEA regulation of erythrocyte differentiation IMP lymphocyte differentiation IEA macrophage differentiation IEA granulocyte differentiation IEA myeloid dendritic cell differentiation IEA somatic stem cell maintenance IEA vasculature development IEA RNA polymerase II transcription factor activity, enhancer binding ISS RNA binding IEA NFAT protein binding ISS Transcription factor PU.1; 31 kDa-transforming protein 10196196 10207087 16554811 1693183 17197705 NA SPI1 -1 Transcription factor PU.1 31 kDa-transforming protein TF 1291 0.0816561705194995 MSTO1 N - Not Matched protein complex IEA mitochondrial outer membrane IDA mitochondrion distribution IMP protein polymerization IEA Protein misato homolog 1 14702039 15489334 16710414 17349998 17974005 18669648 21269460 NA MSTO1 1 Protein misato homolog 1 gene 1296 1.0 NR1H3 T - Transcription nuclear chromatin IDA nucleoplasm TAS cholesterol homeostasis ISS transcription initiation from RNA polymerase II promoter TAS positive regulation of fatty acid biosynthetic process IMP negative regulation of macrophage activation ISS apoptotic cell clearance IMP negative regulation of transcription from RNA polymerase II promoter ISS negative regulation of proteolysis IEA positive regulation of cellular protein metabolic process IMP positive regulation of transcription from RNA polymerase II promoter IDA negative regulation of inflammatory response ISS negative regulation of pinocytosis IMP negative regulation of lipid transport IMP regulation of circadian rhythm TAS cellular lipid metabolic process IEA positive regulation of lipoprotein lipase activity IMP sequence-specific DNA binding IEA sterol response element binding IDA cholesterol binding TAS transcription coactivator activity TAS steroid hormone receptor activity IEA zinc ion binding IEA ligand-dependent nuclear receptor activity TAS Oxysterols receptor LXR-alpha; Liver X receptor alpha; Nuclear receptor subfamily 1 group H member 3 14702039 15489334 16554811 7744246 NA NR1H3 0 Oxysterols receptor LXR-alpha Liver X receptor alpha Nuclear receptor subfamily 1 group H member 3 TF 1291 0.132427427935845 GAS6 D - Genome Maintenance intracellular IEA Golgi lumen TAS endoplasmic reticulum lumen TAS platelet alpha granule lumen TAS extracellular space IDA positive regulation of protein kinase B signaling cascade IDA positive regulation of TOR signaling pathway ISS negative regulation of interleukin-6 production IDA cell proliferation TAS organ regeneration IEA positive regulation of fibroblast proliferation IDA viral genome replication IDA negative regulation of transcription factor activity IDA negative regulation of interleukin-1 secretion IDA positive regulation of protein export from nucleus IDA positive regulation of phagocytosis IDA peptidyl-serine phosphorylation IDA positive regulation of cytokine and chemokine mediated signaling pathway IMP activation of protein kinase B ISS proteolysis TAS cell cycle arrest TAS negative regulation of interferon-gamma production IDA cellular response to starvation IEA negative regulation of apoptosis IEA viral envelope fusion with host membrane IDA cell-substrate adhesion IEA negative regulation of tumor necrosis factor-alpha production IDA apoptotic cell clearance IDA positive regulation of natural killer cell differentiation IDA peptidyl-glutamic acid carboxylation TAS blood coagulation IEA platelet degranulation TAS protein kinase B signaling cascade IDA neuron migration IEA negative regulation of transcription, DNA-dependent IDA virion attachment, binding of host cell surface receptor IDA regulation of growth IEA enzyme linked receptor protein signaling pathway IEA protein tyrosine kinase activator activity IDA voltage-gated calcium channel activity IDA calcium ion binding IEA phosphatidylserine binding IDA caspase inhibitor activity IDA receptor agonist activity IDA Growth arrest-specific protein 6; GAS-6; AXL receptor tyrosine kinase ligand; Precursor 12364394 14702039 15057823 15108283 15489334 16362042 18840707 7854420 7867073 8336730 8621659 8939948 9326368 9326369 NA GAS6 -1 Growth arrest-specific protein 6 GAS-6 AXL receptor tyrosine kinase ligand Precursor gene 1291 0.00323169906125048 MEMO1 N - Not Matched nucleus IDA cytosol IDA Protein MEMO1; C21orf19-like protein; Hepatitis C virus NS5A-transactivated protein 7; HCV NS5A-transactivated protein 7; Mediator of ErbB2-driven cell motility 1; Mediator of cell motility 1; Memo-1 10810093 11707072 14702039 15156151 15489334 15815621 18045866 20937854 21269460 NA MEMO1 1 Protein MEMO1 C21orf19-like protein Hepatitis C virus NS5A-transactivated protein 7 HCV NS5A-transactivated protein 7 Mediator of ErbB2-driven cell motility 1 Mediator of cell motility 1 Memo-1 gene 3018 0.0411817672141367 SLCO3A1 A - Transport and Sensing plasma membrane TAS integral to membrane IEA sodium-independent organic anion transport TAS transporter activity IEA Solute carrier organic anion transporter family member 3A1; OATP3A1; Organic anion transporter polypeptide-related protein 3; OATP-RP3; OATPRP3; Organic anion-transporting polypeptide D; OATP-D; PGE1 transporter; Sodium-independent organic anion transporter D; Solute carrier family 21 member 11 10873595 14702039 15489334 16572171 16971491 NA SO3A1 -1 Solute carrier organic anion transporter family member 3A1 OATP3A1 Organic anion transporter polypeptide-related protein 3 OATP-RP3 OATPRP3 Organic anion-transporting polypeptide D OATP-D PGE1 transporter Sodium-independent organic anion transporter D Solute carrier family 21 member 11 gene 1319 1.0 RBPJ T - Transcription cytoplasm IDA nucleolus IDA nucleoplasm TAS positive regulation of BMP signaling pathway ISS negative regulation of ossification ISS transcription initiation from RNA polymerase II promoter TAS angiogenesis ISS negative regulation of transcription from RNA polymerase II promoter IMP activation of Notch receptor target transcription factor IDA recombinase activity NAS DNA binding TAS Recombining binding protein suppressor of hairless; CBF-1; J kappa-recombination signal-binding protein; RBP-J kappa; RBP-J; RBP-JK; Renal carcinoma antigen NY-REN-30 10508479 10637481 10644367 12374742 14702039 15489334 15815621 16530044 21102556 21991380 22883147 8016657 8406481 8627785 9874765 NA SUH 0 Recombining binding protein suppressor of hairless CBF-1 J kappa-recombination signal-binding protein RBP-J kappa RBP-J RBP-JK Renal carcinoma antigen NY-REN-30 TF 1291 0.0467346765150697 N - Not Matched plasma membrane IEA extracellular region IEA integral to membrane IEA Osteoclast-associated immunoglobulin-like receptor; Osteoclast-associated receptor; hOSCAR; Polymeric immunoglobulin receptor 3; PIgR-3; PIgR3; Poly-Ig receptor 3; Precursor 11805147 14702039 15057824 15489334 NA OSCAR -1 Osteoclast-associated immunoglobulin-like receptor Osteoclast-associated receptor hOSCAR Polymeric immunoglobulin receptor 3 PIgR-3 PIgR3 Poly-Ig receptor 3 Precursor gene 1291 0.142676365585747 WFDC1 C - Cellular Fate and Organization extracellular space NAS negative regulation of cell growth NAS response to drug IEA negative regulation of epithelial cell proliferation IEA response to estradiol stimulus IEA serine-type endopeptidase inhibitor activity IEA WAP four-disulfide core domain protein 1; Prostate stromal protein ps20; ps20 growth inhibitor; Precursor 10967136 14702039 15489334 16959974 NA WFDC1 -1 WAP four-disulfide core domain protein 1 Prostate stromal protein ps20 ps20 growth inhibitor Precursor gene 2911 0.00896578061676545 NEBL N - Not Matched stress fiber IDA Z disc IDA actin filament binding IDA structural constituent of muscle NAS Nebulette; Actin-binding Z-disk protein 10470015 11140941 14702039 15004028 15164054 15489334 9733644 NA NEBL -1 Nebulette Actin-binding Z-disk protein gene 1291 0.0947091236009375 HSPA5 C - Cellular Fate and Organization melanosome IEA ER-Golgi intermediate compartment IDA cell surface IDA endoplasmic reticulum lumen TAS midbody IDA nucleus IMP integral to endoplasmic reticulum membrane IDA negative regulation of apoptosis IMP ER overload response IEA cerebellar Purkinje cell layer development IEA platelet degranulation TAS positive regulation of protein ubiquitination IEA platelet activation TAS cellular response to glucose starvation IDA unfolded protein response, activation of signaling protein activity TAS ER-associated protein catabolic process TAS negative regulation of transforming growth factor beta receptor signaling pathway IEA cerebellum structural organization IEA misfolded protein binding IDA calcium ion binding TAS chaperone binding TAS ribosome binding IEA unfolded protein binding TAS protein binding, bridging NAS ATP binding IEA ATPase activity ISS 78 kDa glucose-regulated protein; GRP-78; Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; Heat shock 70 kDa protein 5; Immunoglobulin heavy chain-binding protein; BiP; Precursor 11160188 12475965 12643545 12699405 1480470 15164053 15489334 17081065 18264092 18502753 20068231 21269460 2294010 2840249 9150946 9150948 NA GRP78 1 78 kDa glucose-regulated protein GRP-78 Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78 Heat shock 70 kDa protein 5 Immunoglobulin heavy chain-binding protein BiP Precursor gene 1291 0.172836979987125 HSPA4 M - Other Metabolism cytoplasm NAS nucleus IDA response to unfolded protein NAS protein import into mitochondrial outer membrane IDA chaperone-mediated protein complex assembly IDA ATP binding NAS Heat shock 70 kDa protein 4; HSP70RY; Heat shock 70-related protein APG-2 15372022 15489334 15592455 17525332 18669648 19608861 19690332 21269460 21406692 8335910 NA HSP74 1 Heat shock 70 kDa protein 4 HSP70RY Heat shock 70-related protein APG-2 gene 1291 0.600369764145397 OLFML2A C - Cellular Fate and Organization extracellular matrix IEA extracellular region IEA extracellular matrix organization and biogenesis IEA extracellular matrix binding IEA Olfactomedin-like protein 2A; Photomedin-1; Precursor 12975309 15164053 15489334 NA OLM2A -1 Olfactomedin-like protein 2A Photomedin-1 Precursor gene 5933 0.00770313866763899 A - Transport and Sensing phagocytic vesicle IDA Golgi membrane IEA SNARE complex IDA lipid raft IDA integral to membrane IEA endosome membrane IEA protein stabilization IDA intracellular protein transport IBA synaptic vesicle exocytosis IBA SNAP receptor activity IBA SNARE binding IBA Syntaxin-12 14702039 15489334 16710414 16959974 17081983 18669648 19546860 21269460 NA STX12 -1 Syntaxin-12 gene 8207 0.00138434977774621 A - Transport and Sensing Golgi apparatus IEA membrane IEA membrane fusion TAS vesicle-mediated transport IEA intracellular protein transport IEA SNAP receptor activity TAS Syntaxin-11 10036234 14574404 15489334 15703195 9553086 9571206 NA STX11 -1 Syntaxin-11 gene 3043 0.104397055026454 LEPRE1 C - Cellular Fate and Organization extracellular matrix (sensu Metazoa) IEA endoplasmic reticulum lumen TAS nucleus IEA negative regulation of cell proliferation NAS regulation of ossification IEA extracellular matrix organization and biogenesis TAS collagen fibril organization IEA cell growth IEA L-ascorbic acid binding IEA iron ion binding IEA procollagen-proline 3-dioxygenase activity IEA oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA Prolyl 3-hydroxylase 1; 1.14.11.7; Growth suppressor 1; Leucine- and proline-enriched proteoglycan 1; Leprecan-1; Precursor 10951563 14702039 15489334 16303743 17277775 19159218 21269460 NA P3H1 1 Prolyl 3-hydroxylase 1 1.14.11.7 Growth suppressor 1 Leucine- and proline-enriched proteoglycan 1 Leprecan-1 Precursor gene 1291 0.0333765276045545 VSIG4 C - Cellular Fate and Organization integral to membrane IEA complement activation, alternative pathway IEA negative regulation of interleukin-2 production IEA negative regulation of T cell proliferation IEA V-set and immunoglobulin domain-containing protein 4; Protein Z39Ig; Precursor 11004523 12975309 15340161 15489334 15772651 17016562 17051150 NA VSIG4 -1 V-set and immunoglobulin domain-containing protein 4 Protein Z39Ig Precursor gene 1291 0.0080442634822031 ALDH3B1 N - Not Matched cytoplasm IDA lipid metabolic process TAS alcohol metabolic process TAS ethanol catabolic process IEA aldehyde catabolic process IDA 3-chloroallyl aldehyde dehydrogenase activity TAS aldehyde dehydrogenase [NAD(P)+] activity IDA Aldehyde dehydrogenase family 3 member B1; 1.2.1.5; Aldehyde dehydrogenase 7 14702039 15489334 17382292 7828891 NA AL3B1 -1 Aldehyde dehydrogenase family 3 member B1 1.2.1.5 Aldehyde dehydrogenase 7 gene 1291 0.167028605541731 N - Not Matched voltage-gated sodium channel complex IDA sodium channel regulator activity IDA Sodium channel subunit beta-4; Precursor 12930796 15489334 17592081 NA SCN4B -1 Sodium channel subunit beta-4 Precursor gene 10315 0.0108332369209013 HMGB3 D - Genome Maintenance chromosome IEA nucleus IEA DNA recombination ISS multicellular organismal development TAS double-stranded DNA binding ISS DNA bending activity ISS High mobility group protein B3; High mobility group protein 2a; HMG-2a; High mobility group protein 4; HMG-4 15489334 15772651 20598277 21269460 9370291 NA HMGB3 1 High mobility group protein B3 High mobility group protein 2a HMG-2a High mobility group protein 4 HMG-4 gene 1291 0.00583307464264129 TAF6 D - Genome Maintenance cytoplasm IDA transcription factor TFIID complex IDA regulation of transcription factor activity IEA RNA elongation from RNA polymerase II promoter TAS transcription initiation from RNA polymerase II promoter IDA negative regulation of cell proliferation IDA viral reproduction TAS negative regulation of progression through cell cycle IDA transcription factor activity IDA DNA binding IDA Transcription initiation factor TFIID subunit 6; RNA polymerase II TBP-associated factor subunit E; Transcription initiation factor TFIID 70 kDa subunit; TAF(II)70; TAFII-70; TAFII70; Transcription initiation factor TFIID 80 kDa subunit; TAF(II)80; TAFII-80; TAFII80 12601814 12690205 14702039 15489334 15601843 15960975 16964243 17974005 18669648 19690332 20068231 21269460 7667268 8262073 NA TAF6 1 Transcription initiation factor TFIID subunit 6 RNA polymerase II TBP-associated factor subunit E Transcription initiation factor TFIID 70 kDa subunit TAF(II)70 TAFII-70 TAFII70 Transcription initiation factor TFIID 80 kDa subunit TAF(II)80 TAFII-80 TAFII80 gene 1291 0.126227128319971 C - Cellular Fate and Organization extracellular space IDA external side of plasma membrane IDA extrinsic to plasma membrane IDA inflammatory response NAS blood coagulation NAS protein homooligomerization IPI endothelial cell differentiation NAS post-embryonic development NAS adult heart development NAS protein heterodimerization activity IDA calcium ion binding TAS identical protein binding IDA Signal peptide, CUB and EGF-like domain-containing protein 1; Precursor 10591208 12270931 16753137 18691976 NA SCUB1 -1 Signal peptide, CUB and EGF-like domain-containing protein 1 Precursor gene 1291 0.00758653205488051 ICMT C - Cellular Fate and Organization membrane TAS endoplasmic reticulum IDA endoplasmic reticulum membrane IEA integral to membrane IEA liver development IEA positive regulation of cell proliferation IEA body growth IEA protein targeting to membrane TAS regulation of Ras protein signal transduction IEA embryonic development (sensu Mammalia) IEA protein-S-isoprenylcysteine O-methyltransferase activity IEA cAMP response element binding protein binding IEA C-terminal protein carboxyl methyltransferase activity TAS Protein-S-isoprenylcysteine O-methyltransferase; 2.1.1.100; Isoprenylcysteine carboxylmethyltransferase; Prenylated protein carboxyl methyltransferase; PPMT; Prenylcysteine carboxyl methyltransferase; pcCMT 10649571 15489334 16710414 19158273 9614111 NA ICMT 1 Protein-S-isoprenylcysteine O-methyltransferase 2.1.1.100 Isoprenylcysteine carboxylmethyltransferase Prenylated protein carboxyl methyltransferase PPMT Prenylcysteine carboxyl methyltransferase pcCMT gene 4604 0.00391962804858022 MACF1 D - Genome Maintenance Golgi apparatus IDA microtubule IDA actin cytoskeleton IEA mesoderm formation IEA establishment and/or maintenance of cell polarity IEA Golgi to plasma membrane protein transport IDA wound healing ISS cell motility IEA positive regulation of Wnt receptor signaling pathway ISS posttranslational protein targeting to membrane IEA cell cycle arrest IEA Wnt receptor signaling pathway IEA regulation of focal adhesion formation ISS microtubule binding NAS actin filament binding NAS calcium ion binding NAS ATPase activity ISS Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5; 620 kDa actin-binding protein; ABP620; Actin cross-linking family protein 7; Macrophin-1; Trabeculin-alpha 10529403 10559237 10574462 11845288 12168954 15265687 16076900 16710414 16959974 17081983 18669648 19608861 19690332 20068231 20937854 21269460 21406692 9455484 NA MACF1 -1 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 620 kDa actin-binding protein ABP620 Actin cross-linking family protein 7 Macrophin-1 Trabeculin-alpha gene 1291 1.03258849283383E-5 FLAD1 M - Other Metabolism cytosol TAS riboflavin metabolic process TAS Mo-molybdopterin cofactor biosynthetic process IEA FAD biosynthetic process IEA FMN adenylyltransferase activity IEA ATP binding IEA FAD synthase; 2.7.7.2; FAD pyrophosphorylase; FMN adenylyltransferase; Flavin adenine dinucleotide synthase; Molybdenum cofactor biosynthesis protein-like region; FAD synthase region 15489334 15498874 16643857 16710414 17049878 18669648 18691976 19369195 21269460 9110174 NA FAD1 1 FAD synthase 2.7.7.2 FAD pyrophosphorylase FMN adenylyltransferase Flavin adenine dinucleotide synthase Molybdenum cofactor biosynthesis protein-like region FAD synthase region gene 1291 0.0555521932186291 SH3GLB1 P - Translation protein complex IEA cytoplasm IDA Golgi membrane IEA mitochondrial outer membrane IEA negative regulation of apoptosis IDA apoptosis IEA posttranslational protein folding IEA positive regulation of protein oligomerization IDA phosphatidic acid biosynthetic process IEA protein oligomerization IDA fatty acid binding IEA lysophosphatidic acid acyltransferase activity IEA Endophilin-B1; Bax-interacting factor 1; Bif-1; SH3 domain-containing GRB2-like protein B1 10810093 11161816 11259440 11604418 12456676 14702039 15452144 15489334 16710414 21269460 21499257 9455484 NA SHLB1 -1 Endophilin-B1 Bax-interacting factor 1 Bif-1 SH3 domain-containing GRB2-like protein B1 gene 1291 0.0783685434449873 N - Not Matched cytoplasm IDA plasma membrane IDA RCC1 domain-containing protein 1 15489334 16572171 21269460 NA RCCD1 1 RCC1 domain-containing protein 1 gene 10472 3.98678218778713E-5 KIAA1462 C - Cellular Fate and Organization adherens junction IEA intercellular junction IEA cell adhesion IEA Junctional protein associated with coronary artery disease; JCAD 10819331 12168954 15164054 15489334 17974005 NA JCAD -1 Junctional protein associated with coronary artery disease JCAD gene 1291 0.0580578706980573 C - Cellular Fate and Organization cytoplasm IBA cell surface IDA integral to plasma membrane IC intercellular junction IEA cell projection IBA positive regulation of transcription factor activity IDA regulation of vascular endothelial growth factor receptor signaling pathway IBA brain development IBA neuron differentiation ISS sensory perception of sound IEA locomotion during locomotory behavior IEA progesterone secretion IBA positive regulation of JNK activity IEA embryonic development IBA positive regulation of transcription, DNA-dependent IDA vasculogenesis IBA frizzled-2 signaling pathway IDA Wnt receptor activity IDA Wnt-protein binding IBA G-protein coupled receptor activity IEA PDZ domain binding IDA Frizzled-4; Fz-4; hFz4; FzE4; CD344; Precursor 10544037 12172548 14507768 14702039 15035989 15223780 15370539 15488808 15489334 15733276 15981244 16554811 16959974 17093393 17955262 19172507 19324841 20141357 20340138 22575959 9707618 NA FZD4 -1 Frizzled-4 Fz-4 hFz4 FzE4 CD344 Precursor gene 5527 0.0126543239549583 HMGA1 D - Genome Maintenance transcription factor complex TAS cytosol TAS protein complex assembly TAS negative regulation of cell proliferation IMP base-excision repair IDA virus-host interaction IEA DNA unwinding during replication NAS viral reproduction TAS nucleosome disassembly TAS response to virus IEP negative regulation of transcription, DNA-dependent IMP transcription, DNA-dependent IEA negative regulation of chromatin silencing TAS DNA-(apurinic or apyrimidinic site) lyase activity IDA 5'-deoxyribose-5-phosphate lyase activity IDA retinoid X receptor binding IDA transcription factor activity IMP ligand-dependent nuclear receptor transcription coactivator activity IMP AT DNA binding TAS peroxisome proliferator activated receptor binding IDA High mobility group protein HMG-I/HMG-Y; HMG-I(Y); High mobility group AT-hook protein 1; High mobility group protein A1; High mobility group protein R 10428834 11978964 12653562 14574404 15489334 15835918 16157300 16159886 1692833 17081983 17525332 17924679 17960875 18318008 18669648 19367720 19608861 19690332 20068231 21269460 21406692 2505228 2701943 2920035 3619901 8414980 9253416 NA HMGA1 1 High mobility group protein HMG-I/HMG-Y HMG-I(Y) High mobility group AT-hook protein 1 High mobility group protein A1 High mobility group protein R TF 1291 0.0783685434449873 ABCC3 M - Other Metabolism integral to plasma membrane TAS bile acid transport TAS bile acid metabolic process TAS ATPase activity, coupled to transmembrane movement of substances TAS organic anion transporter activity TAS ATP binding TAS Canalicular multispecific organic anion transporter 2; ATP-binding cassette sub-family C member 3; Multi-specific organic anion transporter D; MOAT-D; Multidrug resistance-associated protein 3 10094960 14759258 15489334 16625196 18669648 9270026 9738950 9813153 9827529 9889399 NA MRP3 1 Canalicular multispecific organic anion transporter 2 ATP-binding cassette sub-family C member 3 Multi-specific organic anion transporter D MOAT-D Multidrug resistance-associated protein 3 gene 11957 0.00550844870783072 RRM2 D - Genome Maintenance nucleoplasm TAS ribonucleoside-diphosphate reductase complex IEA cytosol TAS DNA replication NAS deoxyribonucleoside diphosphate metabolic process IEA G1/S-specific transcription in mitotic cell cycle TAS deoxyribonucleotide biosynthetic process ISS nucleobase, nucleoside and nucleotide interconversion TAS transition metal ion binding IEA ribonucleoside-diphosphate reductase activity ISS Ribonucleoside-diphosphate reductase subunit M2; 1.17.4.1; Ribonucleotide reductase small chain; Ribonucleotide reductase small subunit 11978970 14702039 15489334 15815621 1627826 16964243 17693683 17924679 18669648 18691976 19690332 20068231 21269460 21406692 NA RIR2 1 Ribonucleoside-diphosphate reductase subunit M2 1.17.4.1 Ribonucleotide reductase small chain Ribonucleotide reductase small subunit gene 4167 0.00168587195553932 KLF11 D - Genome Maintenance nucleus TAS negative regulation of cell proliferation IDA positive regulation of apoptosis IDA S-phase-specific transcription in mitotic cell cycle IDA apoptosis IEA negative regulation of transcription from RNA polymerase II promoter IDA zinc ion binding IEA Krueppel-like factor 11; Transforming growth factor-beta-inducible early growth response protein 2; TGFB-inducible early growth response protein 2; TIEG-2 10207080 11087666 14702039 15489334 15774581 15815621 9748269 NA KLF11 -1 Krueppel-like factor 11 Transforming growth factor-beta-inducible early growth response protein 2 TGFB-inducible early growth response protein 2 TIEG-2 gene 11942 2.95779027276842E-5 KLF10 C - Cellular Fate and Organization nucleus TAS skeletal development TAS negative regulation of cell proliferation TAS cell proliferation TAS cell-cell signaling TAS positive regulation of osteoclast differentiation IEA transforming growth factor beta receptor signaling pathway TAS negative regulation of transcription from RNA polymerase II promoter TAS induction of apoptosis IEA bone mineralization IEA somatic stem cell maintenance IEA transcription, DNA-dependent IEA transcription factor activity TAS zinc ion binding IEA DNA binding IEA Krueppel-like factor 10; EGR-alpha; Transforming growth factor-beta-inducible early growth response protein 1; TGFB-inducible early growth response protein 1; TIEG-1 12072443 12804117 14702039 15489334 16421571 18669648 8532536 8584037 9721211 NA KLF10 -1 Krueppel-like factor 10 EGR-alpha Transforming growth factor-beta-inducible early growth response protein 1 TGFB-inducible early growth response protein 1 TIEG-1 gene 1291 0.0850964838047879 TBC1D2B C - Cellular Fate and Organization intracellular IEA phospholipid binding IEA Rab GTPase activator activity IEA TBC1 domain family member 2B 10470851 14702039 15489334 16572171 18318008 18669648 19690332 20068231 NA TBD2B -1 TBC1 domain family member 2B gene 1291 9.22127029133089E-4 D - Genome Maintenance extracellular region IEA multicellular organismal development IEA spermatogenesis IEA cell differentiation IEA mannose metabolic process IEA mannose-6-phosphate isomerase activity IEA Spermatogenesis-associated protein 20; Sperm-specific protein 411; Ssp411; Precursor 14702039 15489334 16625196 NA SPT20 1 Spermatogenesis-associated protein 20 Sperm-specific protein 411 Ssp411 Precursor gene 1291 0.0439244987968563 C - Cellular Fate and Organization cytoplasm NAS nucleus NAS positive regulation of interleukin-6 production ISS retinal ganglion cell axon guidance IEA positive regulation of interleukin-1 alpha production ISS positive regulation of cell proliferation IEA axon regeneration IEA ventricular cardiac muscle morphogenesis ISS positive regulation of interleukin-1 beta production ISS neural crest cell migration IEA pituitary gland development IEA trigeminal nerve development ISS positive regulation of interleukin-12 production ISS negative regulation of neuron apoptosis ISS positive regulation of insulin secretion IC positive regulation of interferon-gamma production ISS visceral motor neuron differentiation IEA spinal cord motor neuron differentiation ISS positive regulation of granulocyte macrophage colony-stimulating factor production ISS positive regulation of tumor necrosis factor-alpha production ISS spinal cord motor neuron cell fate specification IEA positive regulation of tyrosine phosphorylation of Stat3 protein IEA mesenchymal cell differentiation ISS neuron fate specification ISS negative regulation of transcription from RNA polymerase II promoter ISS positive regulation of angiogenesis ISS negative regulation of neuron differentiation IEA pancreas development ISS negative regulation of inflammatory response ISS positive regulation of DNA binding IEA sensory system development ISS peripheral nervous system neuron axonogenesis ISS ligand-dependent nuclear receptor binding ISS transcription factor activity IEA chromatin binding IEA estrogen receptor binding ISS zinc ion binding IEA Insulin gene enhancer protein ISL-1; Islet-1 15489334 18088087 7907017 7912209 NA ISL1 -1 Insulin gene enhancer protein ISL-1 Islet-1 gene 1291 0.0717638596053337 C - Cellular Fate and Organization transcription factor complex ISS nucleolus IDA pattern specification process ISS ureteric bud branching ISS inner ear morphogenesis ISS sensory perception of sound IEA thymus development ISS negative regulation of transcription from RNA polymerase II promoter IEA induction of an organ ISS thyroid gland development ISS embryonic cranial skeleton morphogenesis ISS transcription, DNA-dependent ISS negative regulation of neuron apoptosis ISS striated muscle development ISS positive regulation of transcription from RNA polymerase II promoter IDA epithelial cell differentiation ISS regulation of neuron differentiation ISS middle ear morphogenesis IEA regulation of synaptic growth at neuromuscular junction IEA facial nerve morphogenesis IEA myoblast migration ISS sequence-specific DNA binding IDA transcription factor activity ISS chromatin binding IEA Homeobox protein SIX1; Sine oculis homeobox homolog 1 15141091 15489334 17637804 18330911 21280147 8617500 NA SIX1 1 Homeobox protein SIX1 Sine oculis homeobox homolog 1 gene 4559 0.430071674356879 ABLIM3 C - Cellular Fate and Organization cytoplasm NAS axon guidance TAS positive regulation of transcription from RNA polymerase II promoter IEA cytoskeleton organization and biogenesis IEA zinc ion binding NAS Actin-binding LIM protein 3; abLIM-3; Actin-binding LIM protein family member 3 10048485 14702039 15221005 15489334 17081983 17194709 17974005 18088087 18318008 NA ABLM3 -1 Actin-binding LIM protein 3 abLIM-3 Actin-binding LIM protein family member 3 gene 1291 0.0714360801321983 ABLIM1 C - Cellular Fate and Organization cytoplasm IEA actin cytoskeleton TAS axon guidance TAS positive regulation of transcription from RNA polymerase II promoter IEA cytoskeleton organization and biogenesis IEA organ morphogenesis TAS visual perception TAS actin binding TAS zinc ion binding IEA Actin-binding LIM protein 1; abLIM-1; Actin-binding LIM protein family member 1; Actin-binding double zinc finger protein; LIMAB1; Limatin 12168954 14702039 15144186 15164054 15489334 15592455 17194709 17525332 17974005 18088087 18669648 19690332 20068231 21406692 7584044 9245787 NA ABLM1 -1 Actin-binding LIM protein 1 abLIM-1 Actin-binding LIM protein family member 1 Actin-binding double zinc finger protein LIMAB1 Limatin gene 4424 0.0160033796822725 FAM189A2 N - Not Matched integral to membrane IEA Protein FAM189A2; Protein X123; Precursor 14702039 15164053 15489334 21406692 7951235 NA F1892 -1 Protein FAM189A2 Protein X123 Precursor gene 2252 1.0 ELK3 C - Cellular Fate and Organization mitochondrion IDA nucleus IC signal transduction TAS wound healing IEA angiogenesis IEA negative regulation of transcription, DNA-dependent IDA transcription, DNA-dependent IEA transcription factor activity NAS transcription corepressor activity IDA purine-rich negative regulatory element binding IDA ETS domain-containing protein Elk-3; ETS-related protein ERP; ETS-related protein NET; Serum response factor accessory protein 2; SAP-2; SRF accessory protein 2 14702039 15489334 18691976 7540136 7958835 NA ELK3 0 ETS domain-containing protein Elk-3 ETS-related protein ERP ETS-related protein NET Serum response factor accessory protein 2 SAP-2 SRF accessory protein 2 TF 1456 0.276294261892595 CRISPLD2 C - Cellular Fate and Organization transport vesicle IDA extracellular matrix IEA extracellular region IEA extracellular matrix organization and biogenesis IEA heparin binding IEA Cysteine-rich secretory protein LCCL domain-containing 2; Cysteine-rich secretory protein 11; CRISP-11; LCCL domain-containing cysteine-rich secretory protein 2; Precursor 11230166 12975309 14702039 15489334 NA CRLD2 -1 Cysteine-rich secretory protein LCCL domain-containing 2 Cysteine-rich secretory protein 11 CRISP-11 LCCL domain-containing cysteine-rich secretory protein 2 Precursor gene 2961 1.0 C - Cellular Fate and Organization nucleus IC nerve growth factor receptor signaling pathway TAS Toll signaling pathway TAS positive regulation of transcription from RNA polymerase II promoter IDA innate immune response TAS MyD88-dependent toll-like receptor signaling pathway TAS stress-activated MAPK cascade TAS transcription, DNA-dependent IEA sequence-specific DNA binding IEA transcription factor activity IDA ETS domain-containing protein Elk-1 10231026 10637505 10742173 12887893 14702039 14992729 15210726 15489334 15772651 15920481 1630903 17296730 18669648 19690332 2539641 7889942 8855261 9430721 9795224 NA ELK1 0 ETS domain-containing protein Elk-1 TF 1291 0.0359059239895385 C - Cellular Fate and Organization microfibril NAS signal transduction IEA cell adhesion NAS Microfibril-associated glycoprotein 4; Precursor 14702039 15340161 15489334 16335952 16625196 19159218 7633408 NA MFAP4 -1 Microfibril-associated glycoprotein 4 Precursor gene 1291 0.114556492608207 N - Not Matched phosphoric monoester hydrolase activity IEA Myotubularin-related protein 10 14702039 15489334 16572171 17974005 20068231 21406692 NA MTMRA -1 Myotubularin-related protein 10 gene 1291 0.00448150748680999 HEBP1 N - Not Matched mitochondrion IEA extracellular region TAS cytosol IEA circadian rhythm TAS heme binding ISS Heme-binding protein 1; p22HBP 10640688 12413491 14702039 15489334 21269460 NA HEBP1 -1 Heme-binding protein 1 p22HBP gene 1291 7.91637519637533E-4 MIS18A D - Genome Maintenance cytoplasm IDA nucleoplasm TAS chromosome, pericentric region IEA mitosis IEA cell division IEA Protein Mis18-alpha; FAPP1-associated protein 1 10773462 14702039 15489334 16303743 17199038 18669648 20068231 NA MS18A 1 Protein Mis18-alpha FAPP1-associated protein 1 gene 1291 0.0657251629046597 NDST1 C - Cellular Fate and Organization Golgi membrane TAS integral to membrane IEA respiratory gaseous exchange IEA carbohydrate metabolic process TAS embryonic viscerocranium morphogenesis IEA heparan sulfate proteoglycan biosynthetic process TAS embryonic neurocranium morphogenesis IEA glycosaminoglycan biosynthetic process TAS smoothened signaling pathway IEA inflammatory response IEA MAPKKK cascade IEA fibroblast growth factor receptor signaling pathway IEA midbrain development IEA forebrain development IEA heparin biosynthetic process IEA polysaccharide biosynthetic process IEA deacetylase activity IEA [heparan sulfate]-glucosamine N-sulfotransferase activity IEA Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1; 2.8.2.8; Glucosaminyl N-deacetylase/N-sulfotransferase 1; NDST-1; N-heparan sulfate sulfotransferase 1; N-HSST 1; [Heparan sulfate]-glucosamine N-sulfotransferase 1; HSNST 1; Heparan sulfate N-deacetylase 1; 3.-.-.-; Heparan sulfate N-sulfotransferase 1; 2.8.2.- 10196134 10758005 12634318 15489334 7601448 9230113 9744796 NA NDST1 -1 Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 2.8.2.8 Glucosaminyl N-deacetylase/N-sulfotransferase 1 NDST-1 N-heparan sulfate sulfotransferase 1 N-HSST 1 [Heparan sulfate]-glucosamine N-sulfotransferase 1 HSNST 1 Heparan sulfate N-deacetylase 1 3.-.-.- Heparan sulfate N-sulfotransferase 1 2.8.2.- gene 83829 3.39484118674067E-10 reported 1 mir 1291 0.00275312073119889 A - Transport and Sensing integral to Golgi membrane IDA retrograde vesicle-mediated transport, Golgi to ER IDA Protein RER1 15489334 18669648 18691976 19690332 20068231 21269460 21406692 9309388 NA RER1 1 Protein RER1 gene 3054 0.0218918562607483 BIN2 N - Not Matched cytoplasm IEA phagocytosis, engulfment IMP phospholipid binding IDA Bridging integrator 2; Breast cancer-associated protein 1 10903846 14702039 15489334 16541075 19367720 19690332 23285027 NA BIN2 -1 Bridging integrator 2 Breast cancer-associated protein 1 gene 1291 0.0222487677836032 Uncharacterized protein KIAA0355 15489334 18669648 9205841 NA K0355 -1 Uncharacterized protein KIAA0355 gene 1291 0.142229022828119 CRTC3 T - Transcription cytoplasm IDA nucleus IDA activation of CREB transcription factor IEA protein homotetramerization IEA virus-host interaction IEA transcription, DNA-dependent IEA cAMP response element binding protein binding IEA CREB-regulated transcription coactivator 3; Transducer of regulated cAMP response element-binding protein 3; TORC-3; Transducer of CREB protein 3 12693554 14506290 14536081 14702039 15454081 15466468 15489334 15589160 16572171 16809310 16817901 16980408 17081983 17210223 17644518 18220336 18669648 18691976 19690332 20068231 NA CRTC3 -1 CREB-regulated transcription coactivator 3 Transducer of regulated cAMP response element-binding protein 3 TORC-3 Transducer of CREB protein 3 gene 1524 0.00302377098474644 MME F - Protein Fate brush border IDA axon ISS integral to plasma membrane NAS dendrite ISS synaptic vesicle ISS kidney development IEP proteolysis IDA creatinine metabolic process IMP sensory perception of pain ISS beta-amyloid metabolic process ISS peptide binding ISS zinc ion binding IDA metalloendopeptidase activity IMP Neprilysin; 3.4.24.11; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; Neutral endopeptidase 24.11; NEP; Neutral endopeptidase; Skin fibroblast elastase; SFE; CD10 10669592 12754519 14702039 14747736 15283675 15489334 17101991 17704566 19756956 20876573 2528730 2531377 2968607 2971756 3162217 8168535 NA NEP -1 Neprilysin 3.4.24.11 Atriopeptidase Common acute lymphocytic leukemia antigen CALLA Enkephalinase Neutral endopeptidase 24.11 NEP Neutral endopeptidase Skin fibroblast elastase SFE CD10 gene 1291 0.379666317727118 DKK3 C - Cellular Fate and Organization extracellular space TAS adrenal gland development IEP Wnt receptor signaling pathway IEA anatomical structure morphogenesis TAS negative regulation of transcription, DNA-dependent IDA negative regulation of aldosterone biosynthetic process IDA Dickkopf-related protein 3; Dickkopf-3; Dkk-3; hDkk-3; Precursor 10570958 10652205 11814687 12975309 14702039 15340161 15489334 16554811 17143291 19838169 23234360 NA DKK3 -1 Dickkopf-related protein 3 Dickkopf-3 Dkk-3 hDkk-3 Precursor gene 1291 0.0886312797080639 ALOX5 R - Stress and Defence nuclear membrane IDA nuclear envelope lumen IDA nuclear matrix IDA cytosol IDA leukotriene biosynthetic process IDA leukotriene production during acute inflammatory response IEA arachidonate 5-lipoxygenase activity IDA iron ion binding IDA lipoxygenase activity IEA Arachidonate 5-lipoxygenase; 5-LO; 5-lipoxygenase; 1.13.11.34 11844797 15164054 15280375 15308583 1540191 15489334 16275640 18978352 19233132 1939225 19807693 21233389 2251250 2526519 2565035 2829172 3118366 3422434 8245774 NA LOX5 -1 Arachidonate 5-lipoxygenase 5-LO 5-lipoxygenase 1.13.11.34 gene 1291 0.0121869290946382 STK39 C - Cellular Fate and Organization basolateral plasma membrane IEA cytoplasm NAS apical plasma membrane IEA nucleus NAS cytoskeleton IEA response to stress NAS regulation of inflammatory response IEA positive regulation of potassium ion transport IEA receptor signaling protein serine/threonine kinase activity NAS ATP binding NAS STE20/SPS1-related proline-alanine-rich protein kinase; Ste-20-related kinase; 2.7.11.1; DCHT; Serine/threonine-protein kinase 39 10980603 14988727 15815621 17487921 18088087 19608861 19690332 20068231 21269460 21406692 NA STK39 1 STE20/SPS1-related proline-alanine-rich protein kinase Ste-20-related kinase 2.7.11.1 DCHT Serine/threonine-protein kinase 39 gene 1291 1.03258849283383E-5 NA 1 gene 2640 1.1389936556535E-4 AGTR1 C - Cellular Fate and Organization integral to plasma membrane IC calcium-mediated signaling IDA kidney development IMP renin-angiotensin regulation of blood vessel size IC Rho protein signal transduction IDA regulation of cell growth NAS positive regulation of phospholipase A2 activity IMP regulation of vasoconstriction IDA positive regulation of cellular protein metabolic process IMP regulation of vasodilation IC renin-angiotensin regulation of aldosterone production NAS regulation of cell proliferation NAS elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) IDA positive regulation of inflammatory response TAS angiotensin type II receptor activity IDA angiotensin type I receptor activity IDA Type-1 angiotensin II receptor; AT1AR; AT1BR; Angiotensin II type-1 receptor; AT1 1378723 1508224 1543512 1550596 1567413 15809376 16116425 7792812 8135787 NA AGTR1 -1 Type-1 angiotensin II receptor AT1AR AT1BR Angiotensin II type-1 receptor AT1 gene 1291 6.17614106217859E-5 N - Not Matched mitochondrion IDA ribosome IEA 28S ribosomal protein S34, mitochondrial; MRP-S34; S34mt 11279123 15489334 21269460 NA RT34 1 28S ribosomal protein S34, mitochondrial MRP-S34 S34mt gene 1291 0.00556253733701826 MICAL1 C - Cellular Fate and Organization intermediate filament NAS cytoplasm IDA signal transduction NAS negative regulation of apoptosis IEA negative regulation of protein amino acid phosphorylation IEA actin filament depolymerization IDA negative regulation of caspase activity IEA oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen IDA actin binding IDA zinc ion binding IEA Protein-methionine sulfoxide oxidase MICAL1; 1.14.13.-; Molecule interacting with CasL protein 1; MICAL-1; NEDD9-interacting protein with calponin homology and LIM domains 11214971 11827972 12110185 12788069 14574404 14702039 15489334 15694364 16959974 17043746 17081983 17662518 17974005 18305261 19690332 21269460 21406692 21864500 NA MICA1 -1 Protein-methionine sulfoxide oxidase MICAL1 1.14.13.- Molecule interacting with CasL protein 1 MICAL-1 NEDD9-interacting protein with calponin homology and LIM domains gene 1291 0.283263917962596 PRX N - Not Matched cytoplasm IEA plasma membrane IEA nucleus IEA axon ensheathment NAS Periaxin 10997877 11133365 11157804 15057824 15489334 22847150 NA PRAX -1 Periaxin gene 1291 0.169823635651924 LRRC59 N - Not Matched mitochondrial nucleoid IDA endoplasmic reticulum IDA endoplasmic reticulum membrane IEA nuclear envelope IEA integral to membrane IEA Leucine-rich repeat-containing protein 59; Ribosome-binding protein p34; p34 11964394 14702039 15489334 16541025 18669648 21269460 22321063 NA LRC59 1 Leucine-rich repeat-containing protein 59 Ribosome-binding protein p34 p34 gene 1291 0.0262453699169434 FRMD3 N - Not Matched cytoplasm IEA integral to membrane IEA cytoskeleton IEA extrinsic to membrane IEA FERM domain-containing protein 3; Band 4.1-like protein 4O; Ovary type protein 4.1; 4.1O 12601556 14702039 15164053 15489334 17260017 17974005 NA FRMD3 -1 FERM domain-containing protein 3 Band 4.1-like protein 4O Ovary type protein 4.1 4.1O gene 1291 0.0714360801321983 MYCT1 N - Not Matched nucleus IEA Myc target protein 1; Myc target in myeloid cells protein 1 12673574 14562369 14574404 14702039 15489334 17974005 NA MYCT1 -1 Myc target protein 1 Myc target in myeloid cells protein 1 gene 1295 0.125999029888139 GADD45B D - Genome Maintenance nucleus IEA activation of MAPKK activity IEA activation of MAPKKK activity TAS response to stress TAS regulation of cell cycle IEA apoptosis TAS multicellular organismal development IEA negative regulation of protein kinase activity IEA cell differentiation IEA Growth arrest and DNA damage-inducible protein GADD45 beta; Myeloid differentiation primary response protein MyD118; Negative growth regulatory protein MyD118 10773677 12716909 14702039 15057824 15489334 9827804 NA GA45B -1 Growth arrest and DNA damage-inducible protein GADD45 beta Myeloid differentiation primary response protein MyD118 Negative growth regulatory protein MyD118 gene 2074 0.113998436121522 N - Not Matched cytosol TAS galactose catabolic process IDA cellular metabolic process IEA coenzyme binding IEA UDP-glucose 4-epimerase activity IDA nucleotide binding IEA UDP-glucose 4-epimerase; 5.1.3.2; Galactowaldenase; UDP-galactose 4-epimerase 10801319 11117433 11279193 11903335 15175331 15489334 15639193 16301867 16302980 16710414 21269460 8593531 9326324 9538513 9973283 NA GALE 1 UDP-glucose 4-epimerase 5.1.3.2 Galactowaldenase UDP-galactose 4-epimerase gene 6510 1.02982467025235E-4 AKT3 C - Cellular Fate and Organization Golgi apparatus IDA plasma membrane IDA nucleus IDA signal transduction IMP mitochondrial genome maintenance IMP phospholipid binding IEA protein serine/threonine kinase activity IDA ATP binding IDA RAC-gamma serine/threonine-protein kinase; 2.7.11.1; Protein kinase Akt-3; Protein kinase B gamma; PKB gamma; RAC-PK-gamma; STK-2 10092583 10208883 10491192 11230166 11387345 11707444 11839817 12162751 15466193 15489334 16540465 16710414 17178867 17344846 17525332 18524868 18813315 19713527 20018949 20059950 20167810 21191416 21269460 21620960 9512493 NA AKT3 -1 RAC-gamma serine/threonine-protein kinase 2.7.11.1 Protein kinase Akt-3 Protein kinase B gamma PKB gamma RAC-PK-gamma STK-2 gene 1291 0.00429830845076463 A - Transport and Sensing Golgi apparatus TAS AP-3 adaptor complex IDA cytoplasmic vesicle membrane IEA anterograde synaptic vesicle transport ISS anterograde axon cargo transport ISS intracellular protein transport TAS protein transporter activity IEA AP-3 complex subunit sigma-2; AP-3 complex subunit sigma-3B; Adapter-related protein complex 3 sigma-2 subunit; Sigma-3B-adaptin; Sigma3B-adaptin; Sigma-adaptin 3b 15489334 9118953 NA AP3S2 1 AP-3 complex subunit sigma-2 AP-3 complex subunit sigma-3B Adapter-related protein complex 3 sigma-2 subunit Sigma-3B-adaptin Sigma3B-adaptin Sigma-adaptin 3b gene 1291 0.0816080920104172 WWC2 Protein WWC2; BH-3-only member B; WW domain-containing protein 2 14702039 15489334 15815621 17974005 20068231 21406692 NA WWC2 -1 Protein WWC2 BH-3-only member B WW domain-containing protein 2 gene 2638 7.31983728649938E-6 MRPS23 P - Translation mitochondrion IDA nuclear membrane IDA ribosome IEA intermediate filament cytoskeleton IDA translation IEA structural constituent of ribosome IEA 28S ribosomal protein S23, mitochondrial; MRP-S23; S23mt 10810093 10938081 11543634 14702039 15489334 19608861 21269460 NA RT23 1 28S ribosomal protein S23, mitochondrial MRP-S23 S23mt gene 1291 5.92757397109183E-5 KLRF1 C - Cellular Fate and Organization integral to plasma membrane TAS cell surface receptor linked signal transduction TAS carbohydrate binding IEA MHC class I receptor activity TAS Killer cell lectin-like receptor subfamily F member 1; Lectin-like receptor F1; Activating coreceptor NKp80; C-type lectin domain family 5 member C 10671213 11265639 11513955 15489334 16541075 NA KLRF1 -1 Killer cell lectin-like receptor subfamily F member 1 Lectin-like receptor F1 Activating coreceptor NKp80 C-type lectin domain family 5 member C gene 1291 0.00238951736395554 N - Not Matched integral to membrane IEA Putative uncharacterized protein C14orf132 14702039 17974005 NA CN132 -1 Putative uncharacterized protein C14orf132 gene 1620 8.53524093194441E-4 MMP9 C - Cellular Fate and Organization extracellular matrix (sensu Metazoa) IEA extracellular space IDA skeletal development IEA positive regulation of apoptosis IEA positive regulation of keratinocyte migration IMP extracellular matrix disassembly TAS embryo implantation IEA collagen catabolic process IEA proteolysis IDA macrophage differentiation TAS collagen binding TAS zinc ion binding TAS metalloendopeptidase activity IDA Matrix metalloproteinase-9; MMP-9; 3.4.24.35; 92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B; GELB; 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9; Precursor 10598806 10644727 11179305 11780052 12051944 12077439 12126625 12879005 1371271 1400481 1464361 14702039 1480034 15489334 1645657 16512877 1653055 1653238 18455130 1932376 19615667 19893577 2551898 7669817 8426746 NA MMP9 1 Matrix metalloproteinase-9 MMP-9 3.4.24.35 92 kDa gelatinase 92 kDa type IV collagenase Gelatinase B GELB 67 kDa matrix metalloproteinase-9 82 kDa matrix metalloproteinase-9 Precursor gene 1291 0.106951875741358 SCARA5 A - Transport and Sensing cell surface IEA integral to plasma membrane ISS iron ion homeostasis ISS scavenger receptor activity IEA Scavenger receptor class A member 5; Scavenger receptor hlg 12975309 14702039 15489334 NA SCAR5 -1 Scavenger receptor class A member 5 Scavenger receptor hlg gene 1291 2.86417363433285E-4 MMP7 C - Cellular Fate and Organization extracellular matrix (sensu Metazoa) IEA extracellular space TAS defense response to Gram-negative bacterium IEA extracellular matrix disassembly TAS defense response to Gram-positive bacterium IEA regulation of cell proliferation IEA response to drug IEA collagen catabolic process IEA proteolysis TAS antibacterial peptide secretion IEA zinc ion binding IEA metalloendopeptidase activity TAS Matrilysin; 3.4.24.23; Matrin; Matrix metalloproteinase-7; MMP-7; Pump-1 protease; Uterine metalloproteinase; Precursor 1497627 15489334 2253219 2550050 2844164 7756291 8294454 NA MMP7 1 Matrilysin 3.4.24.23 Matrin Matrix metalloproteinase-7 MMP-7 Pump-1 protease Uterine metalloproteinase Precursor gene 1291 0.00137163971806715 SLC25A39 A - Transport and Sensing mitochondrial inner membrane IEA integral to membrane IEA transport IEA heme biosynthetic process IEA Solute carrier family 25 member 39 10810093 11139402 11230166 11256614 14702039 15489334 NA S2539 1 Solute carrier family 25 member 39 gene 1343 0.0359755478244374 T - Transcription immunological synapse IEA integral to plasma membrane TAS extracellular space IDA external side of plasma membrane IEA response to ethanol IEA regulation of cell shape IEA adhesion to symbiont IDA leukocyte migration IEP regulation of cell adhesion IEA positive regulation of nitric oxide biosynthetic process IEA ovarian follicle development IEA activation of NF-kappaB transcription factor IEA positive regulation of vasoconstriction IEA response to ionizing radiation IEA cellular response to nutrient levels IEA leukocyte adhesion IMP membrane to membrane docking IEP negative regulation of calcium ion transport IEA response to amino acid stimulus IEA heterophilic cell adhesion TAS cell aging IEA response to drug IEA positive regulation of cellular extravasation IMP response to amphetamine IEA T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IMP regulation of immune response TAS regulation of leukocyte mediated cytotoxicity TAS response to copper ion IEA virion attachment, binding of host cell surface receptor IDA T cell antigen processing and presentation IEA cell surface binding IEA transmembrane receptor activity TAS Intercellular adhesion molecule 1; ICAM-1; Major group rhinovirus receptor; CD54; Precursor 10391210 10562537 11160747 11173916 12526797 14702039 15099525 15489334 15572059 16004874 16335952 1680919 17174307 17875742 18669648 19159218 19349973 1968231 1983003 20068231 21269460 2538243 2544880 3340213 3349522 7525451 8557254 9259284 9539702 9539703 NA ICAM1 1 Intercellular adhesion molecule 1 ICAM-1 Major group rhinovirus receptor CD54 Precursor gene 1291 3.44635661894574E-5 ANXA1 D - Genome Maintenance sarcolemma IEA cilium IEA protein complex IEA basolateral plasma membrane IEA cytoplasm TAS mitochondrial membrane IEA plasma membrane IDA nucleus IEA extracellular space IEA cornified envelope IDA negative regulation of apoptosis TAS response to X-ray IEA alpha-beta T cell differentiation ISS response to drug IEA positive regulation of prostaglandin biosynthetic process IEA response to peptide hormone stimulus IEA cell motility TAS positive regulation of vesicle fusion IDA negative regulation of acute inflammatory response IEA gliogenesis IEA cell cycle IEA inflammatory response TAS peptide cross-linking IDA keratinocyte differentiation IDA endocrine pancreas development IEA regulation of cell proliferation IEA negative regulation of protein secretion IEA insulin secretion IEA response to estradiol stimulus IEA cell surface receptor linked signal transduction TAS arachidonic acid secretion IEA calcium-dependent phospholipid binding IDA structural molecule activity IDA calcium ion binding TAS receptor binding TAS phospholipase A2 inhibitor activity IDA protein binding, bridging IDA Annexin A1; Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; Phospholipase A2 inhibitory protein; p35 15485879 15489334 1832554 18669648 19608861 20068231 21269460 2457390 2532504 2936963 3303336 8425544 8453382 9915835 NA ANXA1 -1 Annexin A1 Annexin I Annexin-1 Calpactin II Calpactin-2 Chromobindin-9 Lipocortin I Phospholipase A2 inhibitory protein p35 gene 1291 0.0947091236009375 MMP1 F - Protein Fate extracellular matrix (sensu Metazoa) IEA extracellular region TAS extracellular matrix disassembly TAS blood coagulation TAS virus-host interaction IEA collagen catabolic process IEA proteolysis TAS leukocyte migration TAS calcium ion binding IEA zinc ion binding TAS metalloendopeptidase activity IDA Interstitial collagenase; 3.4.24.7; Fibroblast collagenase; Matrix metalloproteinase-1; MMP-1; 22 kDa interstitial collagenase; 27 kDa interstitial collagenase; Precursor 15489334 1645757 16807369 2167156 2557822 3009463 3027129 3030290 3032950 3037355 7656013 8031754 8090713 8278810 9484219 NA MMP1 1 Interstitial collagenase 3.4.24.7 Fibroblast collagenase Matrix metalloproteinase-1 MMP-1 22 kDa interstitial collagenase 27 kDa interstitial collagenase Precursor gene 1291 0.283263917962596 ADAMTSL4 F - Protein Fate interstitial matrix IEA positive regulation of apoptosis IDA extracellular matrix organization and biogenesis IEA apoptosis IEA metalloendopeptidase activity IEA ADAMTS-like protein 4; ADAMTSL-4; Thrombospondin repeat-containing protein 1; Precursor 12706885 12975309 15489334 15498874 16335952 16364318 16710414 19200529 21989719 NA ATL4 -1 ADAMTS-like protein 4 ADAMTSL-4 Thrombospondin repeat-containing protein 1 Precursor gene 1782 0.00150036516911254 ADAMTSL3 F - Protein Fate extracellular matrix (sensu Metazoa) IEA zinc ion binding IEA metallopeptidase activity IEA ADAMTS-like protein 3; ADAMTSL-3; Punctin-2; Precursor 10574462 12508121 14667842 15489334 16959974 17597111 NA ATL3 -1 ADAMTS-like protein 3 ADAMTSL-3 Punctin-2 Precursor gene 5042 4.66954698211986E-4 CBFA2T3 C - Cellular Fate and Organization Golgi membrane IEA nucleolus IEA nucleoplasm IEA cell proliferation TAS positive regulation of transcription from RNA polymerase II promoter IEA granulocyte differentiation IDA transcription, DNA-dependent IEA transcription factor activity IEA chromatin binding IEA zinc ion binding IEA Protein CBFA2T3; MTG8-related protein 2; Myeloid translocation gene on chromosome 16 protein; hMTG16; Zinc finger MYND domain-containing protein 4 10995019 11224496 11533236 11823486 12183414 12242670 15231665 15470020 15489334 15676213 16815842 16959974 16966434 17203973 19690332 20138877 9596646 9790752 NA MTG16 -1 Protein CBFA2T3 MTG8-related protein 2 Myeloid translocation gene on chromosome 16 protein hMTG16 Zinc finger MYND domain-containing protein 4 gene 3527 0.0586146050434715 C - Cellular Fate and Organization mitochondrion IEA plasma membrane IEA blood vessel remodeling IEA elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) IEA positive regulation of inflammatory response IEA apoptotic cell clearance IDA isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine IEA protein homooligomerization IEA induction of apoptosis IEA positive regulation of I-kappaB kinase/NF-kappaB cascade IEA positive regulation of smooth muscle cell proliferation IEA positive regulation of cell adhesion ISS protein-glutamine gamma-glutamyltransferase activity ISS GTP binding IEA metal ion binding IEA Protein-glutamine gamma-glutamyltransferase 2; 2.3.2.13; Tissue transglutaminase; Transglutaminase C; TG(C); TGC; TGase C; Transglutaminase H; TGase H; Transglutaminase-2; TGase-2 11780052 1358880 14702039 15489334 1670766 16959974 17939176 18092889 21269460 8611626 NA TGM2 -1 Protein-glutamine gamma-glutamyltransferase 2 2.3.2.13 Tissue transglutaminase Transglutaminase C TG(C) TGC TGase C Transglutaminase H TGase H Transglutaminase-2 TGase-2 gene 1291 0.117179770282665 COX20 N - Not Matched mitochondrion IDA mitochondrial membrane IEA integral to membrane IEA Cytochrome c oxidase protein 20 homolog 15489334 16710414 21269460 22356826 NA COX20 1 Cytochrome c oxidase protein 20 homolog gene 1291 0.14228945765784 MRPS16 P - Translation mitochondrial small ribosomal subunit IDA translation NAS structural constituent of ribosome NAS 28S ribosomal protein S16, mitochondrial; MRP-S16; S16mt; Precursor 10810093 11279123 11402041 11543634 15489334 15505824 18669648 19690332 20068231 21269460 21406692 NA RT16 1 28S ribosomal protein S16, mitochondrial MRP-S16 S16mt Precursor gene 1291 1.0 T - Transcription cytoplasm IDA spliceosome IEA transcription elongation factor complex TAS RNA splicing IEA mRNA processing IEA transcription termination from RNA polymerase II promoter TAS regulation of transcription, DNA-dependent IEA ATP-dependent helicase activity IEA zinc ion binding IEA ATP binding IEA DNA binding IEA DNA-dependent ATPase activity TAS Transcription termination factor 2; 3.6.4.-; Lodestar homolog; RNA polymerase II termination factor; Transcription release factor 2; F2; HuF2 10455150 12927788 14702039 15125840 15489334 16710414 18669648 18691976 20068231 21269460 9748214 NA TTF2 0 Transcription termination factor 2 3.6.4.- Lodestar homolog RNA polymerase II termination factor Transcription release factor 2 F2 HuF2 TF 1291 0.0050181180805082 WISP2 C - Cellular Fate and Organization plasma membrane IEA extracellular space IDA signal transduction TAS cell-cell signaling TAS cell adhesion IEA regulation of cell growth IEA WNT1-inducible-signaling pathway protein 2; WISP-2; CCN family member 5; Connective tissue growth factor-like protein; CTGF-L; Connective tissue growth factor-related protein 58; Precursor 10358067 11780052 12975309 14702039 15340161 15489334 9843955 NA WISP2 -1 WNT1-inducible-signaling pathway protein 2 WISP-2 CCN family member 5 Connective tissue growth factor-like protein CTGF-L Connective tissue growth factor-related protein 58 Precursor gene 1291 0.103206130668939 CXCL2 R - Stress and Defence extracellular space TAS immune response IEA inflammatory response TAS chemotaxis TAS response to molecule of bacterial origin IDA chemokine activity TAS C-X-C motif chemokine 2; Growth-regulated protein beta; Gro-beta; Macrophage inflammatory protein 2-alpha; MIP2-alpha; GRO-beta(5-73); GRO-beta-T; Hematopoietic synergistic factor; HSF; SB-251353; Precursor 10600366 10725737 15489334 2078213 2201751 2217207 2341726 NA CXCL2 -1 C-X-C motif chemokine 2 Growth-regulated protein beta Gro-beta Macrophage inflammatory protein 2-alpha MIP2-alpha GRO-beta(5-73) GRO-beta-T Hematopoietic synergistic factor HSF SB-251353 Precursor gene 1291 0.274618126864437 STK10 D - Genome Maintenance plasma membrane IDA cell cycle IEA protein amino acid autophosphorylation IDA polo kinase kinase activity TAS ATP binding IEA protein homodimerization activity IDA Serine/threonine-protein kinase 10; 2.7.11.1; Lymphocyte-oriented kinase 10199912 11903060 12639966 14702039 15372022 15489334 16175573 16964243 17344846 17974005 18088087 18239682 18669648 18691976 19255442 19367720 19369195 19690332 20068231 21269460 21406692 21606217 NA STK10 -1 Serine/threonine-protein kinase 10 2.7.11.1 Lymphocyte-oriented kinase gene 17199 7.04690428322635E-7 PNRC2 T - Transcription cytoplasmic mRNA processing body IDA nucleus IDA deadenylation-independent decapping TAS regulation of transcription, DNA-dependent IEA mRNA catabolic process, nonsense-mediated decay IDA transcription, DNA-dependent IEA Proline-rich nuclear receptor coactivator 2 11042152 11574675 14651967 14702039 15489334 16710414 19150429 NA PNRC2 -1 Proline-rich nuclear receptor coactivator 2 gene 1291 0.408965318196766 MOCS1 M - Other Metabolism nucleus NAS molybdopterin synthase complex IEA cytosol TAS Mo-molybdopterin cofactor biosynthetic process IDA water-soluble vitamin metabolic process TAS 4 iron, 4 sulfur cluster binding IDA GTP binding IEA lyase activity IEA metal ion binding IEA Molybdenum cofactor biosynthesis protein 1; Cell migration-inducing gene 11 protein; Molybdenum cofactor synthesis-step 1 protein A-B; Cyclic pyranopterin monophosphate synthase; 4.1.99.18; Molybdenum cofactor biosynthesis protein A; Cyclic pyranopterin monophosphate synthase accessory protein; Molybdenum cofactor biosynthesis protein C 10917590 11891227 12208140 12754701 14574404 14702039 15180982 15489334 16021469 19608861 9731530 9921896 NA MOCS1 -1 Molybdenum cofactor biosynthesis protein 1 Cell migration-inducing gene 11 protein Molybdenum cofactor synthesis-step 1 protein A-B Cyclic pyranopterin monophosphate synthase 4.1.99.18 Molybdenum cofactor biosynthesis protein A Cyclic pyranopterin monophosphate synthase accessory protein Molybdenum cofactor biosynthesis protein C gene 5798 0.00298885354381607 LRRC32 C - Cellular Fate and Organization integral to plasma membrane TAS negative regulation of activated T cell proliferation IEA negative regulation of cytokine secretion IEA Leucine-rich repeat-containing protein 32; Garpin; Glycoprotein A repetitions predominant; GARP; Precursor 15489334 19159218 21615933 8180135 NA LRC32 -1 Leucine-rich repeat-containing protein 32 Garpin Glycoprotein A repetitions predominant GARP Precursor gene 1291 0.0021046852814931 NAT9 N - Not Matched protein complex IDA N-acetyltransferase activity IEA N-acetyltransferase 9; 2.3.1.-; Embryo brain-specific protein 14702039 15489334 17974005 NA NAT9 1 N-acetyltransferase 9 2.3.1.- Embryo brain-specific protein gene 2188 0.0223969271822838 SEC61A1 F - Protein Fate rough endoplasmic reticulum IEA integral to endoplasmic reticulum membrane ISS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS protein targeting to ER ISS ribosome binding ISS Protein transport protein Sec61 subunit alpha isoform 1; Sec61 alpha-1 14702039 17974005 21269460 NA S61A1 1 Protein transport protein Sec61 subunit alpha isoform 1 Sec61 alpha-1 gene 2329 6.70900233782731E-4 SLC16A3 E - Energy Production nuclear membrane IDA integral to plasma membrane TAS actin cytoskeleton IDA blood coagulation TAS pyruvate metabolic process TAS leukocyte migration TAS monocarboxylic acid transporter activity TAS monocarboxylate porter activity IEA symporter activity IEA Monocarboxylate transporter 4; MCT 4; Solute carrier family 16 member 3 14702039 15489334 17081983 18669648 18691976 20068231 21269460 9425115 NA MOT4 1 Monocarboxylate transporter 4 MCT 4 Solute carrier family 16 member 3 gene 1291 0.0233296160147592 NAT6 N - Not Matched mitochondrion IDA N-acetyltransferase activity IEA N-acetyltransferase 6; 2.3.1.-; Protein fusion-2; Protein fus-2 10644992 11085536 15489334 16641997 NA NAT6 -1 N-acetyltransferase 6 2.3.1.- Protein fusion-2 Protein fus-2 gene 6123 1.87817528533192E-5 PLCL2 A - Transport and Sensing cytoplasm IEA lipid metabolic process IEA phospholipid binding IEA phosphoinositide phospholipase C activity IEA calcium ion binding IEA signal transducer activity IEA Inactive phospholipase C-like protein 2; PLC-L(2); PLC-L2; Phospholipase C-L2; Phospholipase C-epsilon-2; PLC-epsilon-2 10470851 14702039 15489334 17974005 18669648 19690332 20068231 NA PLCL2 -1 Inactive phospholipase C-like protein 2 PLC-L(2) PLC-L2 Phospholipase C-L2 Phospholipase C-epsilon-2 PLC-epsilon-2 gene 1291 0.00106232178122635 C - Cellular Fate and Organization alpha-ketoglutarate dehydrogenase complex (sensu Eukaryota) ISS branched chain family amino acid catabolic process ISS protein serine/threonine kinase activity ISS [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] kinase activity IEA ATP binding ISS [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial; 2.7.11.4; Branched-chain alpha-ketoacid dehydrogenase kinase; BCKD-kinase; BCKDHKIN; Precursor 15489334 17081983 18220336 18691976 19608861 20068231 21406692 22956686 NA BCKD 1 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial 2.7.11.4 Branched-chain alpha-ketoacid dehydrogenase kinase BCKD-kinase BCKDHKIN Precursor gene 1291 0.139183686231134 NETO2 N - Not Matched integral to membrane IEA Neuropilin and tolloid-like protein 2; Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2; Precursor 12975309 14702039 15340161 15489334 17974005 NA NETO2 1 Neuropilin and tolloid-like protein 2 Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2 Precursor gene 1291 2.86417363433285E-4 AIFM1 C - Cellular Fate and Organization mitochondrial intermembrane space IDA perinuclear region IEA mitochondrial membrane part IMP mitochondrial inner membrane IEA nucleus ISS cytosol ISS caspase activation IDA DNA fragmentation during apoptosis TAS neuron differentiation IDA cell redox homeostasis IEA neuron apoptosis IEA FAD binding IEA oxidoreductase activity IEA electron carrier activity TAS DNA binding IEA Apoptosis-inducing factor 1, mitochondrial; 1.-.-.-; Programmed cell death protein 8; Precursor 10913597 12198487 14702039 15489334 15772651 15775970 16365034 16644725 17094969 17967870 18669648 18691976 19418225 20362274 21269460 22019070 22103349 9989411 NA AIFM1 1 Apoptosis-inducing factor 1, mitochondrial 1.-.-.- Programmed cell death protein 8 Precursor gene 1291 7.91637519637533E-4 D - Genome Maintenance cytoplasm IDA DNA-directed RNA polymerase II, core complex IDA nucleolus IEA RNA elongation from RNA polymerase II promoter TAS transcription termination from RNA polymerase III promoter TAS transcription initiation from RNA polymerase II promoter TAS RNA elongation from RNA polymerase III promoter TAS transcription termination from RNA polymerase I promoter TAS RNA elongation from RNA polymerase I promoter TAS transcription initiation from RNA polymerase I promoter TAS mRNA capping TAS positive regulation of viral transcription TAS nuclear mRNA splicing, via spliceosome TAS transcription-coupled nucleotide-excision repair TAS viral reproduction TAS protein amino acid phosphorylation IDA DNA-directed RNA polymerase activity NAS zinc ion binding NAS DNA binding IEA DNA-directed RNA polymerases I, II, and III subunit RPABC3; RNA polymerases I, II, and III subunit ABC3; DNA-directed RNA polymerase II subunit H; DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide; RPB17; RPB8 homolog; hRPB8 15489334 16632472 16809778 21269460 7651387 8524256 9852112 NA RPAB3 1 DNA-directed RNA polymerases I, II, and III subunit RPABC3 RNA polymerases I, II, and III subunit ABC3 DNA-directed RNA polymerase II subunit H DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide RPB17 RPB8 homolog hRPB8 gene 1291 0.00583307464264129 D - Genome Maintenance DNA-directed RNA polymerase II, core complex IDA RNA elongation from RNA polymerase II promoter TAS transcription initiation from RNA polymerase II promoter TAS nuclear mRNA splicing, via spliceosome TAS transcription-coupled nucleotide-excision repair TAS mRNA capping TAS viral reproduction TAS protein amino acid phosphorylation IDA positive regulation of viral transcription TAS nucleotide binding IEA DNA-directed RNA polymerase activity IMP DNA-directed RNA polymerase II subunit RPB4; RNA polymerase II subunit B4; DNA-directed RNA polymerase II subunit D; RNA polymerase II 16 kDa subunit; RPB16 15489334 16282592 21269460 9528765 9852112 NA RPB4 1 DNA-directed RNA polymerase II subunit RPB4 RNA polymerase II subunit B4 DNA-directed RNA polymerase II subunit D RNA polymerase II 16 kDa subunit RPB16 gene 1291 0.0031988344380112 C - Cellular Fate and Organization endoplasmic reticulum IEA integral to plasma membrane ISS extracellular matrix (sensu Metazoa) IEA extracellular space TAS external side of plasma membrane IDA response to hypoxia IEA blood vessel development IEA ventricular cardiac muscle morphogenesis ISS organ regeneration IEA blastocyst development IEA negative regulation of epithelial cell proliferation ISS regulation of protein binding IEA BMP signaling pathway IDA protein kinase cascade IMP liver development ISS immune response IMP activation of NF-kappaB transcription factor IEA transforming growth factor beta receptor complex assembly IEA cell migration ISS cell growth ISS palate development ISS transforming growth factor beta receptor signaling pathway IDA negative regulation of cell motility IDA negative regulation of transforming growth factor beta receptor signaling pathway IEA response to follicle-stimulating hormone stimulus IDA positive regulation of transforming growth factor beta receptor signaling pathway IEA transforming growth factor beta binding IDA SMAD binding IMP coreceptor activity IDA PDZ domain binding ISS heparin binding ISS punt binding IDA Transforming growth factor beta receptor type 3; TGF-beta receptor type 3; TGFR-3; Betaglycan; Transforming growth factor beta receptor III; TGF-beta receptor type III; Precursor 10944857 1333192 14702039 15489334 16710414 16982625 NA TGBR3 -1 Transforming growth factor beta receptor type 3 TGF-beta receptor type 3 TGFR-3 Betaglycan Transforming growth factor beta receptor III TGF-beta receptor type III Precursor gene 1291 0.457101664569587 LRRK2 C - Cellular Fate and Organization Golgi trans face IEA plasma membrane IEA cell soma IDA dendrite cytoplasm IDA lipid raft IEA synaptic vesicle IEA external side of mitochondrial outer membrane IDA intracellular distribution of mitochondria IMP small GTPase mediated signal transduction IEA autophagy IEA positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS negative regulation of neuron maturation IMP determination of adult life span IMP negative regulation of neuroblast proliferation IMP tangential migration from the subventricular zone to the olfactory bulb IMP regulation of locomotion IMP positive regulation of programmed cell death IDA activation of MAPKK activity IDA protein amino acid autophosphorylation IDA peptidyl-serine phosphorylation IDA neuromuscular junction development IMP peptidyl-threonine phosphorylation IDA regulation of membrane potential IMP positive regulation of protein ubiquitination IDA response to oxidative stress IMP tubulin binding IDA GTPase activity IDA GTP binding IDA ATP binding IEA MAP kinase kinase activity IDA GTPase activator activity IDA Leucine-rich repeat serine/threonine-protein kinase 2; 2.7.11.1; Dardarin 15541308 15541309 15680455 15680456 15680457 15726496 15732108 15811454 15852371 15880653 15925109 15929036 16001413 16081470 16087219 16102999 16157901 16157908 16157909 16172858 16240353 16247070 16250030 16251215 16269541 16272164 16272257 16298482 16321986 16333314 16352719 16532471 16533964 16541075 17019612 17344846 17974005 18213618 20949042 21248752 21641266 21850687 22012985 22415848 22952686 NA LRRK2 -1 Leucine-rich repeat serine/threonine-protein kinase 2 2.7.11.1 Dardarin gene 3965 0.0017563292320489 C - Cellular Fate and Organization caveola IDA external side of plasma membrane IDA cytosol IEA response to estrogen stimulus IEA gastrulation IEA cartilage development IEA organ regeneration IEA embryonic cranial skeleton morphogenesis ISS positive regulation of B cell tolerance induction ISS smoothened signaling pathway IEA heart development ISS activation of protein kinase activity ISS peptidyl-serine phosphorylation IDA lens development (sensu Vertebrata) IEA positive regulation of NK T cell differentiation ISS peptidyl-threonine phosphorylation IDA palate development ISS transforming growth factor beta receptor signaling pathway IDA myeloid dendritic cell differentiation ISS embryonic hemopoiesis ISS negative regulation of transforming growth factor beta receptor signaling pathway TAS positive regulation of tolerance induction to self antigen ISS patterning of blood vessels ISS embryo implantation IEA response to nutrient IEA response to drug IDA aging IEA apoptosis IEA positive regulation of mesenchymal cell proliferation ISS gut development IEA embryonic development (sensu Mammalia) IEA positive regulation of smooth muscle cell proliferation IEA receptor-mediated endocytosis IEA response to glucose stimulus IEA response to mechanical stimulus IEA positive regulation of T cell tolerance induction ISS common-partner SMAD protein phosphorylation IEA brain development ISS wound healing IEA positive regulation of skeletal muscle regeneration IEA vasculogenesis ISS transforming growth factor beta binding IDA receptor signaling protein serine/threonine kinase activity IEA transforming growth factor beta receptor activity IDA SMAD binding IDA glycosaminoglycan binding IDA ATP binding IEA metal ion binding IEA transforming growth factor beta receptor activity, type II IEA TGF-beta receptor type-2; TGFR-2; 2.7.11.30; TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TGF-beta receptor type II; TbetaR-II; Precursor 10789724 11212236 11483955 11850637 12121646 12202987 12939140 12941698 1310899 14702039 15235604 1525823 15340161 15731757 16027248 16251899 16959974 16982625 17344846 18243111 18691976 19369195 19883511 20101701 20207738 20358619 21441952 21949523 22113417 7774578 7959019 8812462 8840968 8973329 9472030 9590282 9865696 NA TGFR2 -1 TGF-beta receptor type-2 TGFR-2 2.7.11.30 TGF-beta type II receptor Transforming growth factor-beta receptor type II TGF-beta receptor type II TbetaR-II Precursor gene 1863 1.0 ELF5 C - Cellular Fate and Organization cytoplasm IEA nucleus IEA transcription from RNA polymerase II promoter TAS cell proliferation TAS ectoderm development IEA sequence-specific DNA binding IEA transcription factor activity IEA ETS-related transcription factor Elf-5; E74-like factor 5; Epithelium-restricted ESE-1-related Ets factor; Epithelium-specific Ets transcription factor 2; ESE-2 10506207 14702039 15489334 16554811 9840936 NA ELF5 0 ETS-related transcription factor Elf-5 E74-like factor 5 Epithelium-restricted ESE-1-related Ets factor Epithelium-specific Ets transcription factor 2 ESE-2 TF 1291 0.0026513533162103 GNA11 C - Cellular Fate and Organization cytoplasm TAS heterotrimeric G-protein complex IBA protein amino acid ADP-ribosylation IEA heart development IEA skeletal development IEA platelet activation TAS regulation of melanocyte differentiation IEA G-protein signaling, coupled to cAMP nucleotide second messenger IBA regulation of action potential IBA pigmentation during development IEA G-protein-coupled receptor binding IBA GTPase activity TAS signal transducer activity IBA GTP binding IEA G-protein beta/gamma-subunit binding IBA metal ion binding IEA Guanine nucleotide-binding protein subunit alpha-11; G alpha-11; G-protein subunit alpha-11; Guanine nucleotide-binding protein G(y) subunit alpha 15057824 15489334 1902575 21044946 21269460 7492305 NA GNA11 -1 Guanine nucleotide-binding protein subunit alpha-11 G alpha-11 G-protein subunit alpha-11 Guanine nucleotide-binding protein G(y) subunit alpha gene 1291 0.0467346765150697 EFEMP1 T - Transcription extracellular matrix (sensu Metazoa) TAS extracellular space IDA regulation of transcription, DNA-dependent IDA peptidyl-tyrosine phosphorylation IDA negative regulation of chondrocyte differentiation IDA visual perception TAS epidermal growth factor receptor activity IDA epidermal growth factor receptor binding IDA calcium ion binding IEA EGF-containing fibulin-like extracellular matrix protein 1; Extracellular protein S1-5; Fibrillin-like protein; Fibulin-3; FIBL-3; Precursor 10369267 10601734 11262647 11384588 12242346 14702039 15123717 15489334 17666404 19275936 19804359 19887559 20005202 7799918 8812496 NA FBLN3 -1 EGF-containing fibulin-like extracellular matrix protein 1 Extracellular protein S1-5 Fibrillin-like protein Fibulin-3 FIBL-3 Precursor gene 1291 0.258483180591132 FSTL3 D - Genome Maintenance Golgi apparatus IEA nucleus IDA secretory granule IEA extracellular space IDA negative regulation of BMP signaling pathway IDA positive regulation of cell-cell adhesion IDA ossification IEA adrenal gland development IEA hemopoietic progenitor cell differentiation IDA kidney development IEA lung development IEA positive regulation of transcription from RNA polymerase II promoter IDA negative regulation of osteoclast differentiation IDA spermatogenesis IEA male gonad development IEA transcription, DNA-dependent IEA Follistatin-related protein 3; Follistatin-like protein 3; Follistatin-related gene protein; Precursor 11459787 11948405 12697670 12970321 12975309 14702039 15340161 15451575 15489334 15574124 16150905 16336961 17868029 17878677 18768470 22052913 9671416 NA FSTL3 -1 Follistatin-related protein 3 Follistatin-like protein 3 Follistatin-related gene protein Precursor gene 3041 0.00832015455478777 C - Cellular Fate and Organization transcription factor complex IEA nucleoplasm TAS negative regulation of apoptosis IMP response to estrogen stimulus IEA response to drug IMP apoptosis IEA positive regulation of cardioblast differentiation IEA negative regulation of transcription from RNA polymerase II promoter IDA embryonic development (sensu Mammalia) IEA positive regulation of angiogenesis IDA organ formation IEA liver development IEA endodermal cell fate determination IEA blood coagulation TAS tube morphogenesis IEA positive regulation of transcription from RNA polymerase II promoter IDA phospholipid metabolic process IEA cardiac muscle cell differentiation IEA male gonad development IEP transcription factor activity IDA chromatin binding IEA RNA polymerase II transcription factor activity, enhancer binding IEA zinc ion binding IEA Transcription factor GATA-6; GATA-binding factor 6 10608869 16177791 18669648 19666519 20068231 20581743 20631719 22158542 8975704 9294001 9315713 NA GATA6 -1 Transcription factor GATA-6 GATA-binding factor 6 gene 1291 0.0525502643359139 PPP3CB C - Cellular Fate and Organization plasma membrane ISS calcineurin complex IDA cytosol TAS axon extension TAS heart development IEA signal transduction NAS protein amino acid dephosphorylation ISS T cell differentiation IEA T cell proliferation NAS regulation of synaptic plasticity TAS calcium ion-dependent exocytosis ISS negative regulation of T cell mediated cytotoxicity IEA social behavior IEP protein amino acid phosphorylation ISS memory TAS learning TAS positive regulation of transcription, DNA-dependent NAS T cell homeostasis IEA calmodulin binding IDA protein phosphatase 2B binding IDA drug binding IDA calcium ion binding IDA Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform; 3.1.3.16; CAM-PRP catalytic subunit; Calmodulin-dependent calcineurin A subunit beta isoform 15164054 15489334 1848109 2556704 NA PP2BB -1 Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform 3.1.3.16 CAM-PRP catalytic subunit Calmodulin-dependent calcineurin A subunit beta isoform gene 1291 6.70900233782731E-4 SEC13 D - Genome Maintenance ER to Golgi transport vesicle membrane TAS Nup107-160 complex IDA endoplasmic reticulum membrane TAS cytosol TAS mitotic prometaphase TAS antigen processing and presentation of peptide antigen via MHC class I TAS antigen processing and presentation of exogenous peptide antigen via MHC class II TAS COPII coating of Golgi vesicle TAS mRNA transport IEA intracellular protein transport NAS protein amino acid N-linked glycosylation via asparagine TAS Protein SEC13 homolog; SEC13-like protein 1; SEC13-related protein 12665801 14517296 15489334 16495487 16641997 16957052 18160040 20068231 21269460 7987303 8972206 9110174 NA SEC13 1 Protein SEC13 homolog SEC13-like protein 1 SEC13-related protein gene 1291 1.0 D - Genome Maintenance nuclear chromatin IDA nucleolus IDA nucleoplasm TAS positive regulation of protein kinase B signaling cascade IMP T cell receptor signaling pathway ISS response to estrogen stimulus IEP positive regulation of interleukin-4 production ISS positive regulation of interleukin-5 production IEA negative regulation of fat cell differentiation IMP response to ethanol IEA thymus development IEA positive regulation of interleukin-13 production IEA post-embryonic development IEA ear development IMP regulation of neuron apoptosis IEA developmental growth IEA lens development (sensu Vertebrata) IEA axon guidance IEA humoral immune response IEA positive regulation of transcription from RNA polymerase II promoter IDA cell maturation IEA embryonic hemopoiesis IEA negative regulation of interferon-gamma production IEA regulation of histone H3-K4 methylation IEA positive regulation of T cell differentiation ISS negative regulation of interleukin-2 production IEA TOR signaling pathway ISS inner ear morphogenesis IEA cell fate determination ISS response to drug IEA mesonephros development ISS defense response TAS negative regulation of progression through cell cycle IMP response to virus IEP embryonic development (sensu Mammalia) IEA phosphoinositide 3-kinase cascade ISS sympathetic nervous system development ISS type IV hypersensitivity IEA regulation of CD4-positive, alpha beta T cell differentiation IEA regulation of cytokine biosynthetic process ISS parathyroid gland development IEA pro-T cell differentiation IEA T-helper 2 cell differentiation IEA blood coagulation TAS negative regulation of inflammatory response IMP thymic T cell selection IEA erythrocyte differentiation IEA norepinephrine biosynthetic process ISS neuron migration IEA male gonad development ISS transcription coactivator activity IDA zinc ion binding IEA Trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3 10935639 11389161 15164054 15489334 17224074 1827068 1871134 19690332 2017177 2050118 NA GATA3 0 Trans-acting T-cell-specific transcription factor GATA-3 GATA-binding factor 3 TF 6226 0.0296716259152738 C - Cellular Fate and Organization protein complex IEA nucleoplasm TAS ventral spinal cord interneuron differentiation IEA phagocytosis IEA cell differentiation in hindbrain IEA negative regulation of fat cell differentiation IMP pituitary gland development IEA urogenital system development IEA regulation of histone acetylation IEA positive regulation of megakaryocyte differentiation IEA positive regulation of phagocytosis ISS homeostasis of number of cells within a tissue IEA positive regulation of transcription from RNA polymerase II promoter IDA cell maturation IEA somatic stem cell maintenance IEA negative regulation of Notch signaling pathway IDA inner ear morphogenesis IEA cell fate determination IEA central nervous system neuron development IEA embryonic placenta development IEA neuron fate commitment IEA negative regulation of transcription from RNA polymerase II promoter IEA negative regulation of macrophage differentiation IEA positive regulation of angiogenesis IDA transcription, DNA-dependent IDA positive regulation of erythrocyte differentiation IEA blood coagulation TAS transcription factor activity IDA chromatin binding IDA zinc ion binding IEA Endothelial transcription factor GATA-2; GATA-binding protein 2 1370462 14702039 15489334 16641997 1714909 21670465 21892158 21892162 NA GATA2 -1 Endothelial transcription factor GATA-2 GATA-binding protein 2 TF 2423 0.00374688243165383 BRCC3 D - Genome Maintenance nuclear ubiquitin ligase complex IDA response to X-ray IDA G2/M transition DNA damage checkpoint IMP proteolysis IEA positive regulation of DNA repair IMP double-strand break repair IMP ubiquitin-specific protease activity IMP enzyme regulator activity IDA ubiquitin thiolesterase activity IMP metallopeptidase activity IMP metal ion binding IEA polyubiquitin binding IDA Lys-63-specific deubiquitinase BRCC36; 3.4.19.-; BRCA1-A complex subunit BRCC36; BRCA1/BRCA2-containing complex subunit 3; BRCA1/BRCA2-containing complex subunit 36; BRISC complex subunit BRCC36 1303175 14636569 14702039 15489334 15772651 16707425 17525341 18077395 19202061 19214193 19261746 19261748 19261749 21269460 8247530 NA BRCC3 1 Lys-63-specific deubiquitinase BRCC36 3.4.19.- BRCA1-A complex subunit BRCC36 BRCA1/BRCA2-containing complex subunit 3 BRCA1/BRCA2-containing complex subunit 36 BRISC complex subunit BRCC36 gene 1291 0.0209599656545895 PPIB P - Translation melanosome IEA endoplasmic reticulum lumen NAS protein folding IEA extracellular matrix organization and biogenesis TAS peptide binding IEA peptidyl-prolyl cis-trans isomerase activity NAS unfolded protein binding TAS Peptidyl-prolyl cis-trans isomerase B; PPIase B; 5.2.1.8; CYP-S1; Cyclophilin B; Rotamase B; S-cyclophilin; SCYLP; Precursor 1286667 14702039 1530944 15489334 16572171 17081065 1710767 19781681 2000394 20089953 2040592 21269460 21280149 8197205 NA PPIB 1 Peptidyl-prolyl cis-trans isomerase B PPIase B 5.2.1.8 CYP-S1 Cyclophilin B Rotamase B S-cyclophilin SCYLP Precursor gene 1291 0.0584361174484631 LRPPRC T - Transcription nuclear outer membrane IEA mitochondrial nucleoid IDA condensed nuclear chromosome IDA perinuclear region IDA microtubule IDA nuclear inner membrane IEA nucleoplasm IEA regulation of transcription, DNA-dependent IEA mitochondrion transport along microtubule TAS mRNA transport IEA transcription, DNA-dependent IEA microtubule binding TAS single-stranded DNA binding IEA RNA binding NAS beta-tubulin binding IDA Leucine-rich PPR motif-containing protein, mitochondrial; 130 kDa leucine-rich protein; LRP 130; GP130; Precursor 11585913 11827465 12529507 12832482 14702039 15081402 15139850 15272088 15489334 15815621 15907802 17050673 19608861 21269460 8012652 NA LPPRC 1 Leucine-rich PPR motif-containing protein, mitochondrial 130 kDa leucine-rich protein LRP 130 GP130 Precursor gene 1291 0.030922008657682 C - Cellular Fate and Organization Wnt receptor signaling pathway IEA Leucine-rich repeat flightless-interacting protein 2; LRR FLII-interacting protein 2 10366446 14702039 15489334 15677333 16641997 17081983 17693683 17974005 18220336 18669648 19265123 19367720 19690332 20068231 21220426 21269460 21406692 NA LRRF2 -1 Leucine-rich repeat flightless-interacting protein 2 LRR FLII-interacting protein 2 gene 1291 0.00121217492072079 RNPS1 T - Transcription nuclear speck IEA nucleoplasm TAS cytosol TAS transcription termination from RNA polymerase II promoter TAS mRNA export from nucleus TAS mRNA catabolic process, nonsense-mediated decay IDA nuclear mRNA splicing, via spliceosome TAS mRNA 3'-end processing TAS nucleotide binding IEA mRNA 3'-UTR binding IDA RNA-binding protein with serine-rich domain 1; SR-related protein LDC2 10449421 11118221 11477570 11546874 12944400 14517304 14625303 14702039 14729963 14752011 15489334 15592455 15616553 15684395 16209946 16314458 17081983 17586820 19324961 19608861 21269460 21406692 8543184 9580558 NA RNPS1 1 RNA-binding protein with serine-rich domain 1 SR-related protein LDC2 gene 1338 4.35853120970912E-4 NFE2L2 D - Genome Maintenance centrosome IDA plasma membrane IDA nucleus IDA chromatin IEA cytosol IDA regulation of embryonic development IEA negative regulation of apoptosis IMP transcription from RNA polymerase II promoter TAS positive regulation of blood coagulation IEA unfolded protein response IEA sequence-specific DNA binding IEA transcription factor activity TAS DNA binding IDA Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; Nuclear factor, erythroid derived 2, like 2 11035812 11256947 14702039 15489334 15815621 15983046 16888629 17974005 18387606 19424503 20068231 21196497 21597468 7937919 NA NF2L2 -1 Nuclear factor erythroid 2-related factor 2 NF-E2-related factor 2 NFE2-related factor 2 HEBP1 Nuclear factor, erythroid derived 2, like 2 TF 11557 0.419772356471037 novel -1 mir 1291 0.033540005365038 AGTPBP1 C - Cellular Fate and Organization mitochondrion ISS nucleus IEA cytosol ISS eye photoreceptor cell differentiation ISS neuromuscular process ISS olfactory bulb development ISS cerebellar Purkinje cell differentiation ISS proteolysis IEA adult walking behavior IEA mitochondrion organization and biogenesis ISS neurotransmitter metabolic process IEA tubulin binding ISS zinc ion binding IEA metallocarboxypeptidase activity ISS Cytosolic carboxypeptidase 1; 3.4.17.-; ATP/GTP-binding protein 1; Nervous system nuclear protein induced by axotomy protein 1 homolog 10470851 12168954 14702039 15164053 15489334 16959974 17974005 18669648 19690332 21269460 NA CBPC1 -1 Cytosolic carboxypeptidase 1 3.4.17.- ATP/GTP-binding protein 1 Nervous system nuclear protein induced by axotomy protein 1 homolog gene 3042 0.00287623944915697 TRIM2 F - Protein Fate cytoplasm IDA regulation of neuron apoptosis ISS ubiquitin-protein ligase activity ISS zinc ion binding NAS Tripartite motif-containing protein 2; 6.3.2.-; E3 ubiquitin-protein ligase TRIM2; RING finger protein 86 11331580 15489334 17974005 21478148 9628581 NA TRIM2 1 Tripartite motif-containing protein 2 6.3.2.- E3 ubiquitin-protein ligase TRIM2 RING finger protein 86 gene 1656 1.0 RXRB C - Cellular Fate and Organization nucleoplasm TAS nucleus IEA transcription initiation from RNA polymerase II promoter TAS ventricular cardiac muscle cell differentiation IEA positive regulation of transcription from RNA polymerase II promoter IEA maternal placenta development IEA embryonic development (sensu Mammalia) IEA transcription, DNA-dependent IEA sequence-specific DNA binding IEA transcription factor activity IEA transcription coactivator activity TAS steroid hormone receptor activity IEA zinc ion binding IEA retinoid-X receptor activity TAS Retinoic acid receptor RXR-beta; Nuclear receptor subfamily 2 group B member 2; Retinoid X receptor beta 11782480 12970175 1310259 1315958 1330328 14574404 15489334 8381386 NA RXRB 0 Retinoic acid receptor RXR-beta Nuclear receptor subfamily 2 group B member 2 Retinoid X receptor beta TF 1569 0.0637649345461735 RXRA C - Cellular Fate and Organization nuclear chromatin IDA nucleoplasm TAS transcription initiation from RNA polymerase II promoter TAS ventricular cardiac muscle morphogenesis IEA vitamin metabolic process TAS embryo implantation IEA virus-host interaction IDA positive regulation of transcription from RNA polymerase II promoter IDA ventricular cardiac muscle cell differentiation IEA maternal placenta development IEA negative regulation of transcription from RNA polymerase II promoter IDA embryonic development (sensu Mammalia) IEA cellular lipid metabolic process TAS cholesterol metabolic process TAS sequence-specific DNA binding IEA protein heterodimerization activity IDA transcription coactivator activity TAS steroid hormone receptor activity IEA zinc ion binding IEA retinoid-X receptor activity TAS chromatin DNA binding IEA Retinoic acid receptor RXR-alpha; Nuclear receptor subfamily 2 group B member 1; Retinoid X receptor alpha 10195690 10567404 10669605 10698945 10835357 10882139 10970886 11162439 11259580 11698662 11915042 12039952 1310260 14981089 15047147 15164053 15489334 15610733 16574651 16912044 17205979 18619963 18669648 20068231 20215566 2159111 7746322 7760929 7925381 9267036 9698548 NA RXRA -1 Retinoic acid receptor RXR-alpha Nuclear receptor subfamily 2 group B member 1 Retinoid X receptor alpha gene 1291 0.0684467560661034 B4GALT4 F - Protein Fate Golgi membrane TAS integral to membrane TAS keratan sulfate biosynthetic process TAS membrane lipid metabolic process TAS protein amino acid N-linked glycosylation via asparagine TAS N-acetyllactosamine synthase activity IEA galactosyltransferase activity TAS metal ion binding IEA Beta-1,4-galactosyltransferase 4; Beta-1,4-GalTase 4; Beta4Gal-T4; b4Gal-T4; 2.4.1.-; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4; N-acetyllactosamine synthase; 2.4.1.90; Nal synthase; Lactotriaosylceramide beta-1,4-galactosyltransferase; 2.4.1.275; Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase 10580128 11588157 12975309 15489334 17974005 9597550 9792633 NA B4GT4 1 Beta-1,4-galactosyltransferase 4 Beta-1,4-GalTase 4 Beta4Gal-T4 b4Gal-T4 2.4.1.- UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4 UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4 N-acetyllactosamine synthase 2.4.1.90 Nal synthase Lactotriaosylceramide beta-1,4-galactosyltransferase 2.4.1.275 Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase gene 1291 0.21126419773979 FXYD6 N - Not Matched plasma membrane IDA membrane IEA integral to membrane IEA ion channel activity IEA FXYD domain-containing ion transport regulator 6; Phosphohippolin; Precursor 11230166 12975309 14702039 15146197 15489334 16554811 17357072 17974005 NA FXYD6 -1 FXYD domain-containing ion transport regulator 6 Phosphohippolin Precursor gene 1291 0.258483180591132 BCL2L2 D - Genome Maintenance mitochondrial membrane IEA cytosol IEA negative regulation of apoptosis IMP apoptosis IEA spermatogenesis TAS Sertoli cell proliferation IEA Bcl-2-like protein 2; Bcl2-L-2; Apoptosis regulator Bcl-W 11423909 12508121 12651847 12660157 12952938 14702039 15489334 18669648 19690332 20068231 21269460 21406692 8761287 9039502 NA B2CL2 -1 Bcl-2-like protein 2 Bcl2-L-2 Apoptosis regulator Bcl-W gene 1577 6.56952031458719E-4 GNAQ C - Cellular Fate and Organization nuclear membrane IEA cytoplasm TAS heterotrimeric G-protein complex IBA protein stabilization IMP platelet activation TAS glutamate signaling pathway IBA phospholipase C activation TAS post-embryonic development IEA neuron remodeling IEA heart development IEA protein amino acid ADP-ribosylation IEA skeletal development IEA behavior IEA regulation of melanocyte differentiation IEA regulation of action potential IBA G-protein signaling, adenylate cyclase activating pathway IBA negative regulation of protein kinase activity IMP forebrain neuron development IEA embryonic digit morphogenesis IEA pigmentation during development IEA G-protein-coupled receptor binding IBA GTPase activity TAS signal transducer activity IBA G-protein beta/gamma-subunit binding IBA GTP binding IEA metal ion binding IEA GTPase activator activity IDA Guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding protein alpha-q 12193606 1333286 15164053 15489334 18672896 19078957 21269460 21923740 22307269 7492305 8664309 8825633 8836152 9700850 NA GNAQ -1 Guanine nucleotide-binding protein G(q) subunit alpha Guanine nucleotide-binding protein alpha-q gene 1291 0.00770313866763899 TJP2 C - Cellular Fate and Organization plasma membrane IDA adherens junction IEA nucleoplasm TAS tight junction IDA cytosol TAS cell structure disassembly during apoptosis TAS guanylate kinase activity TAS Tight junction protein ZO-2; Tight junction protein 2; Zona occludens protein 2; Zonula occludens protein 2 10360833 10495427 11018256 12704386 14702039 15164053 15489334 15975580 17081983 17897942 18088087 18318008 18669648 18823282 19690332 20068231 21269460 21406692 7951235 NA ZO2 -1 Tight junction protein ZO-2 Tight junction protein 2 Zona occludens protein 2 Zonula occludens protein 2 gene 1291 0.0109363272005778 M - Other Metabolism Golgi apparatus IDA nucleus IDA lysosome IDA cell death IDA positive regulation of TOR signaling pathway NAS positive regulation of cytolysis IDA virus-host interaction IDA apoptosis IEA phosphoprotein binding IDA GTP binding IDA protein homodimerization activity IDA Ras-related GTP-binding protein A; Rag A; RagA; Adenovirus E3 14.7 kDa-interacting protein 1; FIP-1 11073942 14660641 14702039 15164053 15489334 18497260 20381137 7499430 8995684 9394008 NA RRAGA -1 Ras-related GTP-binding protein A Rag A RagA Adenovirus E3 14.7 kDa-interacting protein 1 FIP-1 gene 2081 2.71420993408912E-4 UBE2I D - Genome Maintenance cytoplasm IEA synaptonemal complex TAS PML body IDA fibrillar center IEA synapse IEA dendrite IEA ubiquitin-dependent protein catabolic process TAS mitosis IEA positive regulation of transcription factor activity IEA chromosome segregation IEA protein sumoylation IDA virus-host interaction IEA proteasomal ubiquitin-dependent protein catabolic process IEA negative regulation of transcription from RNA polymerase II promoter IMP cell division IEA ubiquitin-protein ligase activity TAS SUMO ligase activity IEA ATP binding IEA SUMO-conjugating enzyme UBC9; 6.3.2.-; SUMO-protein ligase; Ubiquitin carrier protein 9; Ubiquitin carrier protein I; Ubiquitin-conjugating enzyme E2 I; Ubiquitin-protein ligase I; p18 10383460 11085938 11157797 11451954 11853669 12072434 12641448 12924945 15378033 15489334 15608651 15616553 15809060 15931224 16620772 16631117 16732283 17005699 17466333 17704809 17956732 18781797 19450230 19608861 19638400 19744555 20077568 20543865 21139563 21269460 8565643 8610150 8668125 8668529 8798754 8824223 9067428 9197546 9261152 9333025 9334332 NA UBC9 -1 SUMO-conjugating enzyme UBC9 6.3.2.- SUMO-protein ligase Ubiquitin carrier protein 9 Ubiquitin carrier protein I Ubiquitin-conjugating enzyme E2 I Ubiquitin-protein ligase I p18 gene 1291 0.00896578061676545 TJP1 C - Cellular Fate and Organization basolateral plasma membrane IDA intercellular canaliculus IEA cell-cell adherens junction TAS gap junction IEA apical part of cell IDA nucleus IEA tight junction IDA apicolateral plasma membrane IEA cytosol TAS response to drug IEA response to ethanol IEA blastocyst formation IEA intercellular junction assembly TAS response to lipopolysaccharide IEA cell structure disassembly during apoptosis TAS negative regulation of vascular permeability IEA Tight junction protein ZO-1; Tight junction protein 1; Zona occludens protein 1; Zonula occludens protein 1 11734628 12023291 12154091 14702039 15183511 15489334 16572171 16737969 17081983 17928286 18220336 18636092 18669648 18823282 19332538 20068231 20093627 20200156 21240187 21269460 21387411 21406692 8395056 NA ZO1 -1 Tight junction protein ZO-1 Tight junction protein 1 Zona occludens protein 1 Zonula occludens protein 1 gene 1291 0.068148169631386 CSRNP1 C - Cellular Fate and Organization nucleus ISS positive regulation of transcription from RNA polymerase II promoter ISS apoptosis NAS skeletal morphogenesis IEA palate development IEA platelet-derived growth factor receptor signaling pathway IEA post-embryonic development IEA transcription, DNA-dependent IEA transcription factor activity ISS DNA binding IEA Cysteine/serine-rich nuclear protein 1; CSRNP-1; Axin-1 up-regulated gene 1 protein; Protein URAX1; TGF-beta-induced apoptosis protein 3; TAIP-3 11526492 15489334 16641997 17974005 NA CSRN1 -1 Cysteine/serine-rich nuclear protein 1 CSRNP-1 Axin-1 up-regulated gene 1 protein Protein URAX1 TGF-beta-induced apoptosis protein 3 TAIP-3 gene 3243 0.0117275879781976 D - Genome Maintenance cytoplasm IEA intercellular junction IEA lateral plasma membrane IEA activation of MAPK activity IEA regulation of cell size IEA G1/S transition of mitotic cell cycle IEA positive regulation of Ras GTPase activity IEA Ras protein signal transduction IEA Ras GTPase activator activity IEA Ras GTPase-activating-like protein IQGAP3 14702039 16710414 18669648 18691976 20068231 21269460 NA IQGA3 1 Ras GTPase-activating-like protein IQGAP3 gene 1507 1.0 C - Cellular Fate and Organization microtubule organizing center IEA nucleus IEA cytosol IEA T-helper 1 cell differentiation IEA antigen processing and presentation IEA myeloid dendritic cell differentiation IEA transcription, DNA-dependent IEA transcription factor activity TAS transcription corepressor activity TAS DNA binding IEA Transcription factor RelB; I-Rel 15489334 1577270 1732739 18669648 19690332 20068231 20873783 22565310 7925301 8441398 NA RELB 0 Transcription factor RelB I-Rel TF 1291 0.00238951736395554 FAM208A Protein FAM208A; CTCL tumor antigen se89-1; Retinoblastoma-associated protein RAP140 10470851 11149944 14702039 15489334 16335952 16641997 16964243 17081983 18669648 18691976 18726359 19690332 20068231 21406692 NA F208A -1 Protein FAM208A CTCL tumor antigen se89-1 Retinoblastoma-associated protein RAP140 gene 14923 1.0 RELA C - Cellular Fate and Organization transcription factor complex IDA cytosol TAS T cell receptor signaling pathway TAS response to hydrogen peroxide IEA positive regulation of cell proliferation IEA membrane protein intracellular domain proteolysis TAS cytokine and chemokine mediated signaling pathway IDA response to cAMP IEA defense response to virus NAS activation of NF-kappaB transcription factor IDA inflammatory response IDA positive regulation of transcription from RNA polymerase II promoter IDA MyD88-dependent toll-like receptor signaling pathway TAS organ morphogenesis IEA positive regulation of interferon type I production TAS positive regulation of chondrocyte differentiation IEA positive regulation of I-kappaB kinase/NF-kappaB cascade IEP response to amino acid stimulus IEA hair follicle development IEA negative regulation of apoptosis IDA nerve growth factor receptor signaling pathway TAS positive regulation of Schwann cell differentiation IEA negative regulation of protein catabolic process IEA response to drug IEA negative regulation of insulin receptor signaling pathway IEA aging IEA regulation of inflammatory response ISS response to morphine IEA response to mechanical stimulus IEA liver development IEA Toll signaling pathway TAS cellular defense response NAS positive regulation of interleukin-12 biosynthetic process IEA response to UV-B IDA innate immune response TAS acetaldehyde metabolic process IEA virus-host interaction IEA response to muramyl dipeptide IEA negative regulation of transcription, DNA-dependent IDA sequence-specific DNA binding IEA RNA polymerase II transcription factor activity, enhancer binding IDA chromatin binding IDA phosphate binding IDA identical protein binding IDA Transcription factor p65; Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 10498867 10521409 10660609 10928981 10938077 11526476 11533489 11931769 12398897 12419806 12456660 12628924 12748188 12871932 14690596 14769797 1493333 15029197 15073167 15125834 15226358 15489334 15516339 15629770 15775976 15799966 16046471 16135789 16214042 16407239 16452207 16477006 16497732 17000776 1732726 1740106 17467953 17620405 18178962 18405956 19058135 19608861 2006423 20164180 20547752 21081649 21269460 22649547 7907305 8152812 8281153 9056676 9315679 9751059 9865693 NA TF65 0 Transcription factor p65 Nuclear factor NF-kappa-B p65 subunit Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 TF 1291 0.0617829085001869 DTX2 F - Protein Fate cytoplasm IEA nuclear membrane IDA protein ubiquitination IEA Notch signaling pathway IEA ligase activity IEA zinc ion binding IEA Probable E3 ubiquitin-protein ligase DTX2; 6.3.2.-; Protein deltex-2; Deltex2; hDTX2; RING finger protein 58 10819331 11564735 12670957 12853948 14702039 15489334 NA DTX2 1 Probable E3 ubiquitin-protein ligase DTX2 6.3.2.- Protein deltex-2 Deltex2 hDTX2 RING finger protein 58 gene 1291 0.166801148888521 NAA40 N - Not Matched N-acetyltransferase activity IEA N-alpha-acetyltransferase 40; 2.3.1.-; N-acetyltransferase 11; NatD catalytic subunit 14702039 15489334 17974005 19660095 21935442 NA NAA40 1 N-alpha-acetyltransferase 40 2.3.1.- N-acetyltransferase 11 NatD catalytic subunit gene 1291 0.00616644798288088 MED20 T - Transcription Srb-mediator complex NAS transcription initiation from RNA polymerase II promoter TAS regulation of transcription from RNA polymerase II promoter TAS DNA-directed RNA polymerase activity NAS Mediator of RNA polymerase II transcription subunit 20; Mediator complex subunit 20; TRF-proximal protein homolog; hTRFP 12584197 14574404 14702039 15175163 15489334 15989967 17974005 21269460 9933582 NA MED20 1 Mediator of RNA polymerase II transcription subunit 20 Mediator complex subunit 20 TRF-proximal protein homolog hTRFP gene 1291 0.0024163096682039 D - Genome Maintenance proteasome core complex (sensu Eukaryota) NAS nucleoplasm TAS cytosol TAS protein polyubiquitination TAS mRNA metabolic process TAS regulation of amino acid metabolic process TAS positive regulation of ubiquitin ligase activity during mitotic cell cycle TAS apoptosis TAS M/G1 transition of mitotic cell cycle TAS regulation of apoptosis TAS negative regulation of ubiquitin ligase activity during mitotic cell cycle TAS anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS S phase of mitotic cell cycle TAS G1/S transition of mitotic cell cycle TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS viral reproduction TAS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS endopeptidase inhibitor activity NAS Proteasome inhibitor PI31 subunit; hPI31 10764772 11780052 15489334 18669648 19690332 20068231 21269460 21406692 NA PSMF1 -1 Proteasome inhibitor PI31 subunit hPI31 gene 1291 0.0183151903166334 DIEXF N - Not Matched nucleolus IEA multicellular organismal development IEA Digestive organ expansion factor homolog 15489334 16710414 17974005 21269460 22002106 NA DIEXF 1 Digestive organ expansion factor homolog gene 1291 0.0979480891694494 MTHFD2 M - Other Metabolism mitochondrion ISS response to heat IEA tetrahydrofolate metabolic process IDA folic acid and derivative biosynthetic process IEA one-carbon compound metabolic process IBA methylenetetrahydrofolate dehydrogenase (NADP+) activity IDA methylenetetrahydrofolate dehydrogenase (NAD+) activity IDA magnesium ion binding IDA nucleotide binding IEA phosphate binding IDA methenyltetrahydrofolate cyclohydrolase activity ISS Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; NAD-dependent methylenetetrahydrofolate dehydrogenase; 1.5.1.15; Methenyltetrahydrofolate cyclohydrolase; 3.5.4.9; Precursor 15489334 15815621 19608861 21269460 2587219 NA MTDC 1 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial NAD-dependent methylenetetrahydrofolate dehydrogenase 1.5.1.15 Methenyltetrahydrofolate cyclohydrolase 3.5.4.9 Precursor gene 1660 0.0367251672414937 D - Genome Maintenance PCNA complex IEA cytoplasm IDA microtubule cytoskeleton IDA nucleoplasm TAS DNA replication factor C complex TAS replication fork (sensu Eukaryota) IDA cell proliferation TAS phosphoinositide-mediated signaling NAS positive regulation of deoxyribonuclease activity IDA bypass DNA synthesis IDA S phase of mitotic cell cycle TAS heart development IEA DNA strand elongation during DNA replication TAS G1/S-specific transcription in mitotic cell cycle TAS transcription-coupled nucleotide-excision repair TAS base-excision repair TAS telomere maintenance via recombination TAS nucleotide-excision repair, DNA gap filling TAS mismatch repair IDA regulation of DNA replication IEA telomere maintenance via semi-conservative replication TAS response to cadmium ion IEA MutLalpha complex binding IDA purine-specific mismatch base pair DNA N-glycosylase activity IDA dinucleotide insertion or deletion binding IDA DNA polymerase processivity factor activity IEA Proliferating cell nuclear antigen; PCNA; Cyclin 11376153 11780052 11784855 12522211 12786946 14702039 15149598 15225546 15489334 15543136 15616578 16510448 16949367 17108083 17115032 17130289 18316726 18499658 18703516 18719106 18794347 18948756 19419956 19443450 19608861 20129063 21269460 21549307 21628590 22153967 22634751 22681887 22704558 22705370 22759634 23000965 2565339 2882422 2882507 8861913 9302295 9305916 9566895 NA PCNA 1 Proliferating cell nuclear antigen PCNA Cyclin gene 1291 0.0146035958550651 MTHFD1 M - Other Metabolism mitochondrion TAS cytosol IBA methionine biosynthetic process IEA folic acid metabolic process TAS folic acid and derivative biosynthetic process IEA one-carbon compound metabolic process IBA histidine biosynthetic process IEA purine nucleotide biosynthetic process IEA methylenetetrahydrofolate dehydrogenase (NADP+) activity IBA methylenetetrahydrofolate dehydrogenase activity TAS formate-tetrahydrofolate ligase activity IBA methenyltetrahydrofolate cyclohydrolase activity IBA ATP binding IEA C-1-tetrahydrofolate synthase, cytoplasmic; C1-THF synthase; Methylenetetrahydrofolate dehydrogenase; 1.5.1.5; Methenyltetrahydrofolate cyclohydrolase; 3.5.4.9; Formyltetrahydrofolate synthetase; 6.3.4.3 10828945 12384833 12665801 14702039 15489334 16552426 17000706 18767138 21269460 3053686 9519408 9611072 NA C1TC 1 C-1-tetrahydrofolate synthase, cytoplasmic C1-THF synthase Methylenetetrahydrofolate dehydrogenase 1.5.1.5 Methenyltetrahydrofolate cyclohydrolase 3.5.4.9 Formyltetrahydrofolate synthetase 6.3.4.3 gene 8693 0.0031988344380112 C - Cellular Fate and Organization integral to plasma membrane TAS extracellular region IEA positive regulation of cell proliferation IDA leukemia inhibitory factor receptor activity IDA Leukemia inhibitory factor receptor; LIF receptor; LIF-R; CD118; Precursor 14740318 16959974 18669648 18775332 1915266 9525740 NA LIFR -1 Leukemia inhibitory factor receptor LIF receptor LIF-R CD118 Precursor gene 8925 1.0 BRCA1 D - Genome Maintenance plasma membrane IDA chromosome ISS ribonucleoprotein complex IDA nucleoplasm TAS BRCA1-BARD1 complex IDA ruffle IDA gamma-tubulin ring complex NAS response to estrogen stimulus IDA DNA damage response, signal transduction resulting in induction of apoptosis IDA regulation of transcription from RNA polymerase III promoter TAS G2/M transition DNA damage checkpoint IMP negative regulation of fatty acid biosynthetic process IMP positive regulation of DNA repair IMP postreplication repair IDA negative regulation of centriole replication NAS protein autoubiquitination IDA cell cycle IEA chromosome segregation IMP positive regulation of histone H3-K4 methylation IDA double-strand break repair via homologous recombination IDA negative regulation of histone H3-K9 methylation IDA positive regulation of transcription from RNA polymerase II promoter IDA response to ionizing radiation IMP regulation of cell proliferation TAS positive regulation of protein ubiquitination IDA fatty acid biosynthetic process IEA DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator TAS negative regulation of transcription, DNA-dependent IDA androgen receptor signaling pathway NAS ubiquitin-protein ligase activity IDA tubulin binding NAS RNA binding IDA transcription coactivator activity NAS zinc ion binding TAS androgen receptor binding NAS Breast cancer type 1 susceptibility protein; 6.3.2.-; RING finger protein 53 10196379 10323242 10486320 10500182 10724175 10783165 10851077 11114888 11239454 11301010 11573085 11573086 11739404 11751867 11836499 11877377 12183412 12215251 12360400 12419185 12427738 12442274 12442275 12887909 12890688 12938098 14636569 14722926 14746861 14976165 14990569 15026808 15096610 15133502 15365993 15456891 15489334 15609993 16101277 16326698 16625196 16698035 16818604 16959974 17081983 17525332 17525340 17643121 17643122 17924331 18056443 18285836 18452305 18669648 18762988 19261746 19261748 19261749 19369211 19690332 20068231 20159462 20351172 20364141 20513136 21406692 21673012 7545954 7894491 7894493 7939630 8554067 8723683 8776600 8807330 8938427 8968716 8972225 9010228 9482581 9528852 9609997 9760198 9811458 NA BRCA1 0 Breast cancer type 1 susceptibility protein 6.3.2.- RING finger protein 53 TF 1291 0.0599310847282657 KAZN N - Not Matched desmosome IDA cytoplasm IDA nuclear membrane IDA cornified envelope IDA keratinization IEA Kazrin 10470851 14702039 15337775 15489334 16710414 9853615 NA KAZRN -1 Kazrin gene 1291 0.18479937517545 MED14 C - Cellular Fate and Organization Srb-mediator complex IDA transcription initiation from RNA polymerase II promoter IDA stem cell maintenance IEA positive regulation of transcription from RNA polymerase II promoter IDA androgen receptor signaling pathway IDA thyroid hormone receptor binding IDA ligand-dependent nuclear receptor transcription coactivator activity NAS vitamin D receptor binding NAS receptor activity IDA Mediator of RNA polymerase II transcription subunit 14; Activator-recruited cofactor 150 kDa component; ARC150; Cofactor required for Sp1 transcriptional activation subunit 2; CRSP complex subunit 2; Mediator complex subunit 14; RGR1 homolog; hRGR1; Thyroid hormone receptor-associated protein complex 170 kDa component; Trap170; Transcriptional coactivator CRSP150; Vitamin D3 receptor-interacting protein complex 150 kDa component; DRIP150 10024883 10235266 10235267 11867769 12218053 12509459 15175163 15340088 15489334 15625066 15989967 16595664 16959974 18669648 18691976 19369195 19690332 20068231 21269460 9598311 9734358 9989412 NA MED14 1 Mediator of RNA polymerase II transcription subunit 14 Activator-recruited cofactor 150 kDa component ARC150 Cofactor required for Sp1 transcriptional activation subunit 2 CRSP complex subunit 2 Mediator complex subunit 14 RGR1 homolog hRGR1 Thyroid hormone receptor-associated protein complex 170 kDa component Trap170 Transcriptional coactivator CRSP150 Vitamin D3 receptor-interacting protein complex 150 kDa component DRIP150 gene 1291 5.87900750477386E-4 SH3BP5 C - Cellular Fate and Organization mitochondrion IEA cytoplasm TAS protein kinase inhibitor activity IDA SH3 domain-binding protein 5; SH3BP-5; SH3 domain-binding protein that preferentially associates with BTK 10339589 12167088 14702039 15489334 16641997 16964243 17974005 18669648 20068231 9571151 NA 3BP5 -1 SH3 domain-binding protein 5 SH3BP-5 SH3 domain-binding protein that preferentially associates with BTK gene 1291 0.111579324401302 C - Cellular Fate and Organization mitochondrion IEA plasma membrane IDA postsynaptic density IEA nucleus IEA endosome IDA cytosol TAS T cell receptor signaling pathway IDA feeding behavior TAS negative regulation of protein catabolic process IEA response to ethanol IEA response to drug IEA regulation of cell shape IEA T cell costimulation TAS platelet activation TAS peptidyl-tyrosine phosphorylation IEA leukocyte migration TAS protein kinase cascade TAS regulation of antiviral response by virus TAS dendrite morphogenesis IEA protein amino acid autophosphorylation IEA axon guidance TAS virus-host interaction IEA viral reproduction TAS calcium ion transport NAS activated T cell proliferation IEA detection of mechanical stimulus during sensory perception of pain IEA forebrain development IEA learning TAS neuron migration IEA non-membrane spanning protein tyrosine kinase activity NAS ATP binding IEA metal ion binding IEA Tyrosine-protein kinase Fyn; 2.7.10.2; Proto-oncogene Syn; Proto-oncogene c-Fyn; Src-like kinase; SLK; p59-Fyn 10196263 10498895 10790433 11005864 11162638 11518702 11536198 12218089 12545174 12788081 14574404 14707117 14761972 1533589 15489334 15489916 15536091 15537652 15557120 16387660 16841086 1699196 17194753 17344846 17925405 18056706 18088087 18258597 18669648 18691976 19054851 19179337 19369195 19652227 19807924 20068231 20100835 3099169 3526330 7568038 7664083 7687536 7822789 8206991 8394019 8681387 8805554 8961927 9038210 9207119 9351806 9741627 NA FYN -1 Tyrosine-protein kinase Fyn 2.7.10.2 Proto-oncogene Syn Proto-oncogene c-Fyn Src-like kinase SLK p59-Fyn gene 1291 2.28100181273671E-4 KIF2A D - Genome Maintenance centrosome IDA spindle pole IEA microtubule associated complex IEA microtubule IEA cytosol TAS antigen processing and presentation of exogenous peptide antigen via MHC class II TAS mitotic prometaphase TAS blood coagulation TAS mitotic spindle organization and biogenesis IDA cell differentiation IEA cell division IEA nervous system development IEA microtubule-based movement TAS motor activity TAS microtubule motor activity IEA ATP binding IEA Kinesin-like protein KIF2A; Kinesin-2; hK2 14702039 15489334 15843429 17538014 17974005 18411309 19351716 19690332 21269460 9177777 NA KIF2A 1 Kinesin-like protein KIF2A Kinesin-2 hK2 gene 1291 4.66954698211986E-4 MAP3K8 D - Genome Maintenance cytosol TAS activation of MAPKK activity IEA cell cycle IEA MAPKKK cascade IEA T cell costimulation TAS magnesium ion binding IEA protein serine/threonine kinase activity TAS MAP kinase kinase kinase activity IEA ATP binding IEA Mitogen-activated protein kinase kinase kinase 8; 2.7.11.25; Cancer Osaka thyroid oncogene; Proto-oncogene c-Cot; Serine/threonine-protein kinase cot; Tumor progression locus 2; TPL-2 10896655 14702039 15164054 15169888 15489334 17472361 1833717 18669648 2072910 8226782 8479752 NA M3K8 -1 Mitogen-activated protein kinase kinase kinase 8 2.7.11.25 Cancer Osaka thyroid oncogene Proto-oncogene c-Cot Serine/threonine-protein kinase cot Tumor progression locus 2 TPL-2 gene 1291 0.0449492875329337 SPINT1 F - Protein Fate membrane TAS extracellular region TAS extracellular matrix organization and biogenesis IEA serine-type endopeptidase inhibitor activity TAS Kunitz-type protease inhibitor 1; Hepatocyte growth factor activator inhibitor type 1; HAI-1; Precursor 10373425 12975309 15340161 15489334 15713485 18669648 9045658 NA SPIT1 1 Kunitz-type protease inhibitor 1 Hepatocyte growth factor activator inhibitor type 1 HAI-1 Precursor gene 1346 0.0374812373281861 SRM N - Not Matched cytosol TAS spermidine biosynthetic process IDA spermidine synthase activity IDA protein homodimerization activity IDA Spermidine synthase; SPDSY; 2.5.1.16; Putrescine aminopropyltransferase 15489334 16710414 17585781 2069720 21269460 2344393 NA SPEE 1 Spermidine synthase SPDSY 2.5.1.16 Putrescine aminopropyltransferase gene 1291 0.379666317727118 SYNM C - Cellular Fate and Organization intermediate filament IDA adherens junction IDA membrane IEA costamere IDA intermediate filament cytoskeleton organization and biogenesis TAS vinculin binding IDA structural constituent of cytoskeleton IDA structural constituent of muscle IDA intermediate filament binding ISS Synemin; Desmuslin 11353857 11454237 11737198 14552890 15489334 16777071 17081983 18028034 18342854 18669648 18691976 20068231 9205841 NA SYNEM -1 Synemin Desmuslin gene 1291 0.300262688080211 PCDHGC3 C - Cellular Fate and Organization plasma membrane IEA membrane NAS integral to membrane IEA calcium-dependent cell-cell adhesion NAS homophilic cell adhesion IEA calcium ion binding IEA Protocadherin gamma-C3; PCDH-gamma-C3; Protocadherin-2; Protocadherin-43; PC-43; Precursor 10380929 15489334 8508762 9360932 NA PCDGK -1 Protocadherin gamma-C3 PCDH-gamma-C3 Protocadherin-2 Protocadherin-43 PC-43 Precursor gene 1291 0.0107333449193607 GFOD1 N - Not Matched extracellular region IEA nucleotide binding IEA oxidoreductase activity IEA Glucose-fructose oxidoreductase domain-containing protein 1; 1.-.-.-; Precursor 14574404 14702039 15489334 NA GFOD1 -1 Glucose-fructose oxidoreductase domain-containing protein 1 1.-.-.- Precursor gene 9929 0.00208005594674944 F - Protein Fate basement membrane IEA negative regulation of membrane protein ectodomain proteolysis IMP visual perception IEA metalloendopeptidase inhibitor activity TAS metal ion binding IEA Metalloproteinase inhibitor 3; Protein MIG-5; Tissue inhibitor of metalloproteinases 3; TIMP-3; Precursor 10591208 14702039 15123717 15461802 15489334 18638486 7550309 7772252 7795886 7894485 8034652 8163205 8174111 8188246 8634721 8666262 8728699 8806658 8808469 8981947 NA TIMP3 -1 Metalloproteinase inhibitor 3 Protein MIG-5 Tissue inhibitor of metalloproteinases 3 TIMP-3 Precursor gene 1291 0.0134562520322556 NEDD4L C - Cellular Fate and Organization nucleoplasm TAS cytosol TAS excretion NAS transcription initiation from RNA polymerase II promoter TAS response to salt stress IEA regulation of protein catabolic process NAS sodium ion homeostasis NAS negative regulation of transcription from RNA polymerase II promoter TAS positive regulation of endocytosis NAS water homeostasis NAS protein ubiquitination during ubiquitin-dependent protein catabolic process IBA response to metal ion IDA virus-host interaction IEA regulation of membrane potential IDA transforming growth factor beta receptor signaling pathway TAS sodium ion transport NAS ubiquitin-dependent protein catabolic process via the multivesicular body pathway IEA negative regulation of transforming growth factor beta receptor signaling pathway TAS ubiquitin-protein ligase activity NAS sodium channel inhibitor activity IEA sodium channel regulator activity IDA E3 ubiquitin-protein ligase NEDD4-like; 6.3.2.-; NEDD4.2; Nedd4-2 11046148 11696533 11748237 11840194 12911626 14556380 14615060 15040001 15140763 15217910 15328345 15489223 15489334 15496141 15548568 15576372 15677482 16177791 17081983 17974005 18669648 18691976 18819914 19144635 19343052 19664597 19690332 20068231 20086093 20525693 20730100 21269460 21406692 9455477 NA NED4L -1 E3 ubiquitin-protein ligase NEDD4-like 6.3.2.- NEDD4.2 Nedd4-2 gene 14898 4.483224160382E-5 NEGR1 C - Cellular Fate and Organization plasma membrane IEA anchored to membrane IEA cell adhesion IEA Neuronal growth regulator 1; IgLON family member 4; Precursor 12975309 14702039 16602701 16710414 17974005 NA NEGR1 -1 Neuronal growth regulator 1 IgLON family member 4 Precursor gene 5632 0.0295255373814214 D - Genome Maintenance cell surface IEA cell soma IEA extracellular region TAS extracellular space IEA basement membrane IEA growth cone IEA negative regulation of cell proliferation IEA response to drug IEA aging IEA regulation of Rap protein signal transduction IEA positive regulation of adenylate cyclase activity IEA central nervous system development IEA negative regulation of proteolysis IEA negative regulation of Ras protein signal transduction IEA extracellular matrix disassembly TAS positive regulation of neuron differentiation IEA negative regulation of progression through mitotic cell cycle IEA positive regulation of MAPKKK cascade IEA metalloendopeptidase inhibitor activity TAS enzyme activator activity IEA metal ion binding IEA Metalloproteinase inhibitor 2; CSC-21K; Tissue inhibitor of metalloproteinases 2; TIMP-2; Precursor 11710594 12032297 1480041 15489334 1655733 1730286 2157214 2380196 2554304 2793861 7918391 8112602 8810321 9705310 9837731 NA TIMP2 1 Metalloproteinase inhibitor 2 CSC-21K Tissue inhibitor of metalloproteinases 2 TIMP-2 Precursor gene 1291 0.123513886575145 TIMP1 C - Cellular Fate and Organization extracellular region NAS platelet alpha granule lumen TAS basement membrane IEA positive regulation of cell proliferation TAS negative regulation of apoptosis IEA erythrocyte maturation IEA negative regulation of membrane protein ectodomain proteolysis IDA extracellular matrix disassembly TAS platelet degranulation TAS aging IEA platelet activation TAS response to peptide hormone stimulus IEA metalloendopeptidase inhibitor activity IDA metal ion binding IEA Metalloproteinase inhibitor 1; Erythroid-potentiating activity; EPA; Fibroblast collagenase inhibitor; Collagenase inhibitor; Tissue inhibitor of metalloproteinases 1; TIMP-1; Precursor 10623524 12834347 1420137 15340161 15489334 16263699 16335952 1653055 16740002 17050530 1730286 21269460 2163605 2171551 3010309 3839290 3903517 7507419 9286280 9288970 NA TIMP1 1 Metalloproteinase inhibitor 1 Erythroid-potentiating activity EPA Fibroblast collagenase inhibitor Collagenase inhibitor Tissue inhibitor of metalloproteinases 1 TIMP-1 Precursor gene 4888 0.150510689252597 C - Cellular Fate and Organization nuclear chromatin IEA cytoplasm TAS nucleus IDA contractile actin filament bundle formation IEA positive regulation of cell differentiation IDA stress fiber formation IEA cell migration during sprouting angiogenesis IMP positive regulation of filopodium formation IEA regulation of cell adhesion IEA neurite development IEA muscle maintenance ISS tangential migration from the subventricular zone to the olfactory bulb IEA heart looping ISS positive regulation of transcription factor activity IDA developmental growth IEA neuron development TAS positive regulation of smooth muscle contraction IDA erythrocyte development IEA cardiac myofibril assembly IEA mRNA transcription from RNA polymerase II promoter ISS response to hormone stimulus IDA platelet formation IEA associative learning IEA response to hypoxia IEP patterning of blood vessels IEA mesoderm formation IEA regulation of smooth muscle cell differentiation TAS morphogenesis of an epithelial sheet IEA sarcomere organization IEA platelet activation IEA response to toxin TAS trophectodermal cell differentiation IDA positive thymic T cell selection IEA hippocampus development IEA cell-matrix adhesion IEA skin morphogenesis IEA neuron migration IEA RNA polymerase II transcription factor activity, enhancer binding IEA chromatin DNA binding IEA Serum response factor; SRF 14574404 1512232 1547771 15489334 16054032 17081983 18497331 18669648 19350017 20068231 21406692 3203386 7637780 8375385 8407951 NA SRF -1 Serum response factor SRF TF 3295 0.0117275879781976 HS3ST1 N - Not Matched Golgi lumen TAS integral to membrane TAS carbohydrate metabolic process TAS glycosaminoglycan biosynthetic process TAS sulfotransferase activity TAS heparin-glucosamine 3-O-sulfotransferase activity IEA Heparan sulfate glucosamine 3-O-sulfotransferase 1; 2.8.2.23; Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1; 3-OST-1; Heparan sulfate 3-O-sulfotransferase 1; h3-OST-1; Precursor 14702039 15489334 8900198 9346953 9988767 9988768 NA HS3S1 1 Heparan sulfate glucosamine 3-O-sulfotransferase 1 2.8.2.23 Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1 3-OST-1 Heparan sulfate 3-O-sulfotransferase 1 h3-OST-1 Precursor gene 1291 0.283263917962596 C - Cellular Fate and Organization integral to plasma membrane TAS extracellular space IEA immune response TAS inflammatory response TAS neuropeptide signaling pathway IEA cell-cell signaling TAS cell motility TAS cell adhesion TAS G-protein coupled receptor activity TAS calcium ion binding IEA CD97 antigen; Leukocyte antigen CD97; CD97; CD97 antigen subunit alpha; CD97 antigen subunit beta; Precursor 11297558 12829604 14647991 14702039 15057824 15489334 18669648 18691976 19159218 19349973 20068231 7636245 8786105 8955192 NA CD97 -1 CD97 antigen Leukocyte antigen CD97 CD97 CD97 antigen subunit alpha CD97 antigen subunit beta Precursor gene 1291 0.00675092610057069 FCN1 C - Cellular Fate and Organization collagen IEA extracellular space IEA signal transduction IEA innate immune response IEA opsonization TAS calcium ion binding TAS carbohydrate binding TAS antigen binding TAS Ficolin-1; Collagen/fibrinogen domain-containing protein 1; Ficolin-A; Ficolin-alpha; M-ficolin; Precursor 14702039 15164053 15340161 15489334 16959974 17148457 17897951 20032467 20400674 8573080 8947836 NA FCN1 -1 Ficolin-1 Collagen/fibrinogen domain-containing protein 1 Ficolin-A Ficolin-alpha M-ficolin Precursor gene 1291 0.0335786645917271 SYNC N - Not Matched intermediate filament IEA sarcolemma IEA Z disc IEA perinuclear region IEA neuromuscular junction IEA cytosol IEA intermediate filament-based process IEA structural molecule activity IEA Syncoilin; Syncoilin intermediate filament 1; Syncoilin-1 14702039 15489334 16124004 16710414 20068231 NA SYNCI -1 Syncoilin Syncoilin intermediate filament 1 Syncoilin-1 gene 2194 0.024546100231356 CD93 C - Cellular Fate and Organization plasma membrane IDA cell surface IEA cytoplasmic membrane-bound vesicle IEA integral to membrane IC phagocytosis NAS cell-cell adhesion IDA macrophage activation NAS virus-host interaction IEA complement component C1q binding IDA calcium ion binding IEA carbohydrate binding IEA receptor activity NAS Complement component C1q receptor; C1q/MBL/SPA receptor; C1qR; C1qR(p); C1qRp; CDw93; Complement component 1 q subcomponent receptor 1; Matrix-remodeling-associated protein 4; CD93; Precursor 10092817 11086025 11780052 11781389 11994479 15489334 16959974 9047234 9233640 NA C1QR1 -1 Complement component C1q receptor C1q/MBL/SPA receptor C1qR C1qR(p) C1qRp CDw93 Complement component 1 q subcomponent receptor 1 Matrix-remodeling-associated protein 4 CD93 Precursor gene 1291 5.71729576935814E-4 ABI3BP C - Cellular Fate and Organization interstitial matrix IEA extracellular space IDA extracellular matrix organization and biogenesis IEA heparin binding IEA Target of Nesh-SH3; Tarsh; ABI gene family member 3-binding protein; Nesh-binding protein; NeshBP; Precursor 11501947 14702039 15489334 17974005 19159218 NA TARSH -1 Target of Nesh-SH3 Tarsh ABI gene family member 3-binding protein Nesh-binding protein NeshBP Precursor gene 1291 0.0550793834643225 D - Genome Maintenance nucleoplasm TAS cytosol TAS protein polyubiquitination TAS regulation of protein catabolic process IEA mRNA metabolic process TAS regulation of amino acid metabolic process TAS positive regulation of ubiquitin ligase activity during mitotic cell cycle TAS apoptosis TAS M/G1 transition of mitotic cell cycle TAS regulation of apoptosis TAS negative regulation of ubiquitin ligase activity during mitotic cell cycle TAS anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS S phase of mitotic cell cycle TAS G1/S transition of mitotic cell cycle TAS viral reproduction TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS enzyme regulator activity IEA 26S proteasome non-ATPase regulatory subunit 3; 26S proteasome regulatory subunit RPN3; 26S proteasome regulatory subunit S3; Proteasome subunit p58 14702039 15489334 17323924 21269460 9017604 NA PSMD3 1 26S proteasome non-ATPase regulatory subunit 3 26S proteasome regulatory subunit RPN3 26S proteasome regulatory subunit S3 Proteasome subunit p58 gene 1291 0.0783685434449873 SEL1L3 N - Not Matched integral to membrane IEA Protein sel-1 homolog 3; Suppressor of lin-12-like protein 3; Sel-1L3 14702039 15489334 15815621 17974005 18669648 9872452 NA SE1L3 1 Protein sel-1 homolog 3 Suppressor of lin-12-like protein 3 Sel-1L3 gene 1291 0.02695851979802 NR4A3 D - Genome Maintenance transcription factor complex IEA nucleoplasm TAS hippocampus development IEA negative regulation of neuron apoptosis IEA mesoderm formation IEA transcription initiation from RNA polymerase II promoter TAS axon guidance IEA vestibular reflex IEA organ regeneration IEA regulation of balance IEA response to peptide hormone stimulus IEA adult behavior IEA semicircular canal morphogenesis IEA positive regulation of progression through cell cycle IEA sequence-specific DNA binding IEA steroid hormone receptor activity TAS zinc ion binding IEA thyroid hormone receptor activity TAS DNA binding NAS Nuclear receptor subfamily 4 group A member 3; Mitogen-induced nuclear orphan receptor; Neuron-derived orphan receptor 1; Nuclear hormone receptor NOR-1 15164053 8570200 8614405 8634690 8809112 9573341 NA NR4A3 -1 Nuclear receptor subfamily 4 group A member 3 Mitogen-induced nuclear orphan receptor Neuron-derived orphan receptor 1 Nuclear hormone receptor NOR-1 gene 1699 0.00551430130139407 EOGT F - Protein Fate endoplasmic reticulum lumen IEA protein amino acid O-linked glycosylation ISS protein N-acetylglucosaminyltransferase activity ISS EGF domain-specific O-linked N-acetylglucosamine transferase; 2.4.1.255; Extracellular O-linked N-acetylglucosamine transferase; Precursor 14702039 15489334 17974005 NA EOGT -1 EGF domain-specific O-linked N-acetylglucosamine transferase 2.4.1.255 Extracellular O-linked N-acetylglucosamine transferase Precursor gene 1291 0.146300477807647 NR4A1 C - Cellular Fate and Organization transcription factor complex IEA nucleoplasm TAS nerve growth factor receptor signaling pathway TAS transcription initiation from RNA polymerase II promoter TAS positive regulation of endothelial cell proliferation IMP epidermal growth factor receptor signaling pathway TAS fibroblast growth factor receptor signaling pathway TAS phosphoinositide-mediated signaling TAS cell migration during sprouting angiogenesis IDA induction of apoptosis IEA negative regulation of caspase activity IEA sequence-specific DNA binding IEA steroid hormone receptor activity IEA zinc ion binding IEA ligand-dependent nuclear receptor activity TAS DNA binding ISS Nuclear receptor subfamily 4 group A member 1; Early response protein NAK1; Nuclear hormone receptor NUR/77; Nur77; Orphan nuclear receptor HMR; Orphan nuclear receptor TR3; ST-59; Testicular receptor 3 14702039 15459248 15466594 15489334 1651101 16541075 17360704 18669648 18691976 2283997 2626032 NA NR4A1 -1 Nuclear receptor subfamily 4 group A member 1 Early response protein NAK1 Nuclear hormone receptor NUR/77 Nur77 Orphan nuclear receptor HMR Orphan nuclear receptor TR3 ST-59 Testicular receptor 3 gene 1343 0.0651197801949104 DAP3 P - Translation mitochondrion IDA nucleolus IDA mitochondrial ribosome IEA small ribosomal subunit IEA apoptotic mitochondrial changes IEA 28S ribosomal protein S29, mitochondrial; MRP-S29; S29mt; Death-associated protein 3; DAP-3; Ionizing radiation resistance conferring protein; Precursor 11162496 11279123 11543634 14702039 15489334 16710414 17974005 19103604 19608861 20563667 21269460 7499268 NA RT29 1 28S ribosomal protein S29, mitochondrial MRP-S29 S29mt Death-associated protein 3 DAP-3 Ionizing radiation resistance conferring protein Precursor gene 1291 0.0218918562607483 MPP1 C - Cellular Fate and Organization intracellular IDA integral to plasma membrane TAS stereocilium IEA cortical cytoskeleton IEA signal transduction TAS guanylate kinase activity TAS 55 kDa erythrocyte membrane protein; p55; Membrane protein, palmitoylated 1 1301163 14702039 15489334 15772651 16741958 1713685 17584769 18669648 19144871 20068231 21269460 22496366 NA EM55 -1 55 kDa erythrocyte membrane protein p55 Membrane protein, palmitoylated 1 gene 7129 0.188280548365469 ZMIZ1 T - Transcription cytoplasm IEA nuclear speck IEA heart morphogenesis IEA developmental growth IEA cell aging IEA positive regulation of transcription from RNA polymerase II promoter IEA artery morphogenesis IEA positive regulation of fibroblast proliferation IEA vasculogenesis IEA embryonic development (sensu Mammalia) IEA transcription, DNA-dependent IEA vitellogenesis IEA zinc ion binding IEA Zinc finger MIZ domain-containing protein 1; PIAS-like protein Zimp10; Retinoic acid-induced protein 17 10574462 14609956 15164054 16959974 NA ZMIZ1 -1 Zinc finger MIZ domain-containing protein 1 PIAS-like protein Zimp10 Retinoic acid-induced protein 17 gene 1291 0.145385885608534 OLA1 M - Other Metabolism cytoplasm IDA nucleolus IEA ATP catabolic process IDA hydrolase activity IEA GTP binding IEA ATP binding IDA Obg-like ATPase 1; DNA damage-regulated overexpressed in cancer 45; DOC45; GTP-binding protein 9 11230166 14702039 15489334 16959974 17430889 19608861 20053727 21269460 NA OLA1 1 Obg-like ATPase 1 DNA damage-regulated overexpressed in cancer 45 DOC45 GTP-binding protein 9 gene 1291 0.274618126864437 RHOJ C - Cellular Fate and Organization plasma membrane TAS cytosol TAS regulation of small GTPase mediated signal transduction TAS actin cytoskeleton organization and biogenesis IMP small GTPase mediated signal transduction TAS regulation of cell shape IEA Rho protein signal transduction IEA GTPase activity NAS GTP binding IEA Rho-related GTP-binding protein RhoJ; Ras-like protein family member 7B; Tc10-like GTP-binding protein; Precursor 10967094 14702039 15489334 NA RHOJ -1 Rho-related GTP-binding protein RhoJ Ras-like protein family member 7B Tc10-like GTP-binding protein Precursor gene 1291 0.146300477807647 VWF N - Not Matched extracellular matrix IDA endoplasmic reticulum IDA extracellular matrix (sensu Metazoa) IEA extracellular region IDA platelet alpha granule lumen TAS external side of plasma membrane IEA liver development IEA blood coagulation, intrinsic pathway TAS platelet degranulation TAS cell-substrate adhesion IDA platelet activation IDA protein homooligomerization IDA placenta development IEA glycoprotein binding IDA immunoglobulin binding IDA collagen binding IDA chaperone binding IDA protease binding IDA protein homodimerization activity IDA von Willebrand factor; vWF; von Willebrand antigen 2; von Willebrand antigen II; Precursor 10887119 10961880 11698279 12406074 12665801 12871266 1409710 1419803 1419804 1420817 1429668 14760718 15755288 16541075 1672694 1673047 16959974 1729889 17370265 1761120 1832934 1906179 19159218 1988024 2010538 2011604 21592258 2584182 2786201 2828057 2864688 3019665 3089784 3488076 3489923 3495266 3496594 3502076 3524673 3873280 3874428 3875078 7620154 7734373 7789955 7989040 8011991 8088787 8123843 8123844 8338947 8348943 8376405 8435341 8486782 8547152 8622978 9218428 9312128 9331419 9373253 9553097 NA VWF -1 von Willebrand factor vWF von Willebrand antigen 2 von Willebrand antigen II Precursor gene 6540 9.49660655125939E-5 EDNRB C - Cellular Fate and Organization nuclear membrane IEA integral to plasma membrane TAS lipid raft IEA positive regulation of cell proliferation IEA neural crest cell migration IEA G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) TAS cGMP-mediated signaling IEA negative regulation of adenylate cyclase activity TAS elevation of cytosolic calcium ion concentration IEA regulation of pH IEA epithelial fluid transport IEA vasodilation IEA regulation of epithelial cell proliferation IEA negative regulation of apoptosis IEA aging IEA negative regulation of neuron maturation ISS melanocyte differentiation IEA negative regulation of transcription from RNA polymerase II promoter IMP sensory perception of pain IEA negative regulation of cellular protein metabolic process IMP enteric nervous system development ISS peripheral nervous system development IEA blood pressure regulation IEA positive regulation of protein amino acid phosphorylation IEA posterior midgut development IEA response to pain IEA macrophage chemotaxis IMP regulation of sensory perception of pain IEA endothelin receptor activity IDA peptide hormone binding IPI Endothelin B receptor; ET-B; ET-BR; Endothelin receptor non-selective type; Precursor 10072757 11471546 11891690 12189494 12628594 1282938 1291713 14702039 15057823 15489334 1648908 1710450 1713452 7536888 8001158 8429023 8440682 8630503 8634719 8810293 8852659 8852660 9261180 9284755 9359036 9760196 NA EDNRB -1 Endothelin B receptor ET-B ET-BR Endothelin receptor non-selective type Precursor gene 1291 0.13818482481767 SH2B3 C - Cellular Fate and Organization cytosol TAS blood coagulation TAS embryonic hemopoiesis IEA cell differentiation IEA phospholipid binding IEA phosphate binding IEA signal transducer activity IEA SH2B adapter protein 3; Lymphocyte adapter protein; Lymphocyte-specific adapter protein Lnk; Signal transduction protein Lnk 10799879 15489334 17554260 18311140 21406692 NA SH2B3 -1 SH2B adapter protein 3 Lymphocyte adapter protein Lymphocyte-specific adapter protein Lnk Signal transduction protein Lnk gene 1291 0.166801148888521 P - Translation endoplasmic reticulum membrane IEA integral to membrane IEA SRP-dependent cotranslational protein targeting to membrane TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS translation TAS protein translocase activity IEA protein transporter activity ISS Protein transport protein Sec61 subunit gamma 11042152 14702039 15489334 NA SC61G 1 Protein transport protein Sec61 subunit gamma gene 1291 0.123513886575145 TIMM17A F - Protein Fate mitochondrial inner membrane presequence translocase complex IDA integral to mitochondrial inner membrane IDA protein targeting to mitochondrion TAS cellular protein metabolic process TAS protein translocase activity IEA Mitochondrial import inner membrane translocase subunit Tim17-A; Inner membrane preprotein translocase Tim17a 10339406 14702039 15489334 21269460 8893850 NA TI17A 1 Mitochondrial import inner membrane translocase subunit Tim17-A Inner membrane preprotein translocase Tim17a gene 1576 0.416055235370773 D - Genome Maintenance basolateral plasma membrane IDA perinuclear region IDA cell surface IDA nucleus IEA integral to membrane IEA cytoplasmic vesicle IDA extracellular space IDA positive regulation of epithelial cell proliferation IDA negative regulation of apoptosis IEA epidermal growth factor receptor signaling pathway IEA cell proliferation TAS response to drug IEA positive regulation of epidermal growth factor receptor activity IDA wound healing IEA positive regulation of mitosis IDA positive regulation of cell division IEA angiogenesis IEA epidermal growth factor receptor binding IDA growth factor activity IDA MAP kinase kinase activity IDA Protransforming growth factor alpha; Transforming growth factor alpha; TGF-alpha; EGF-like TGF; ETGF; TGF type 1; Precursor 10066034 10230395 10523832 10552925 14702039 15489334 15815621 1632509 17607000 18757723 2050136 2261437 2464748 2907605 6088071 8100397 8224876 8338831 8910478 NA TGFA 1 Protransforming growth factor alpha Transforming growth factor alpha TGF-alpha EGF-like TGF ETGF TGF type 1 Precursor gene 1291 0.0550793834643225 PLA2G12A N - Not Matched Golgi apparatus IEA endoplasmic reticulum IEA extracellular region NAS lipid catabolic process IEA phosphatidic acid biosynthetic process TAS calcium ion binding IEA calcium-dependent phospholipase A2 activity NAS Group XIIA secretory phospholipase A2; GXII sPLA2; sPLA2-XII; 3.1.1.4; Phosphatidylcholine 2-acylhydrolase 12A; Precursor 11031251 12522102 12975309 15489334 NA PG12A 1 Group XIIA secretory phospholipase A2 GXII sPLA2 sPLA2-XII 3.1.1.4 Phosphatidylcholine 2-acylhydrolase 12A Precursor gene 1291 3.95044798301106E-4 STEAP3 D - Genome Maintenance plasma membrane IEA multivesicular body IDA integral to membrane IEA endosome membrane TAS iron ion homeostasis TAS cell cycle IEA protein secretion IMP apoptosis IEA induction of apoptosis IEA nucleotide binding IEA ferric-chelate reductase activity IEA metal ion binding IEA Metalloreductase STEAP3; 1.16.1.-; Dudulin-2; Six-transmembrane epithelial antigen of prostate 3; Tumor suppressor-activated pathway protein 6; hTSAP6; pHyde; hpHyde 10969787 12606722 12866033 14702039 15319436 15489334 15815621 15885357 15897894 16227996 16651434 17974005 18495927 22624035 NA STEA3 1 Metalloreductase STEAP3 1.16.1.- Dudulin-2 Six-transmembrane epithelial antigen of prostate 3 Tumor suppressor-activated pathway protein 6 hTSAP6 pHyde hpHyde gene 1291 0.00150790326259068 PKNOX2 T - Transcription cytoplasm IEA microtubule cytoskeleton IEA nucleus IEA actin cytoskeleton IEA regulation of transcription from RNA polymerase II promoter IEA sequence-specific DNA binding IEA transcription factor activity IEA DNA binding IDA Homeobox protein PKNOX2; Homeobox protein PREP-2; PBX/knotted homeobox 2 11549286 11972344 15489334 17974005 NA PKNX2 -1 Homeobox protein PKNOX2 Homeobox protein PREP-2 PBX/knotted homeobox 2 gene 2239 0.00964032494266694 YPEL5 Protein yippee-like 5 10810093 11240639 15489334 15556292 15815621 21269460 NA YPEL5 -1 Protein yippee-like 5 gene 1291 0.0584361174484631 CASP6 F - Protein Fate nucleoplasm TAS cytosol IDA proteolysis IDA induction of apoptosis TAS cell structure disassembly during apoptosis TAS cysteine-type endopeptidase activity TAS Caspase-6; CASP-6; 3.4.22.59; Apoptotic protease Mch-2; Caspase-6 subunit p18; Caspase-6 subunit p11; Precursor 15200957 15273717 15489334 21269460 7796396 8900201 NA CASP6 1 Caspase-6 CASP-6 3.4.22.59 Apoptotic protease Mch-2 Caspase-6 subunit p18 Caspase-6 subunit p11 Precursor gene 1328 0.154619333409719 VPS72 T - Transcription protein complex IDA nucleus TAS negative regulation of transcription from RNA polymerase II promoter TAS somatic stem cell maintenance IEA transcription, DNA-dependent IEA chromatin modification IEA DNA binding IEA Vacuolar protein sorting-associated protein 72 homolog; Protein YL-1; Transcription factor-like 1 14966270 15489334 15647280 16710414 16959974 7702631 NA VPS72 1 Vacuolar protein sorting-associated protein 72 homolog Protein YL-1 Transcription factor-like 1 gene 1291 0.0439244987968563 GLIPR2 N - Not Matched Golgi membrane IEA extracellular region IEA Golgi-associated plant pathogenesis-related protein 1; GAPR-1; Golgi-associated PR-1 protein; Glioma pathogenesis-related protein 2; GliPR 2 11865038 12137952 14702039 15123429 15164053 15489334 NA GAPR1 -1 Golgi-associated plant pathogenesis-related protein 1 GAPR-1 Golgi-associated PR-1 protein Glioma pathogenesis-related protein 2 GliPR 2 gene 1291 0.00323169906125048 D - Genome Maintenance proteasome core complex (sensu Eukaryota) ISS nucleoplasm TAS cytosol TAS protein polyubiquitination TAS mRNA metabolic process TAS regulation of amino acid metabolic process TAS positive regulation of ubiquitin ligase activity during mitotic cell cycle TAS apoptosis TAS response to organic nitrogen IEA regulation of apoptosis TAS M/G1 transition of mitotic cell cycle TAS negative regulation of ubiquitin ligase activity during mitotic cell cycle TAS anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS S phase of mitotic cell cycle TAS G1/S transition of mitotic cell cycle TAS virus-host interaction IEA viral reproduction TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS threonine endopeptidase activity IEA Proteasome subunit beta type-2; 3.4.25.1; Macropain subunit C7-I; Multicatalytic endopeptidase complex subunit C7-I; Proteasome component C7-I 1286667 14550573 15489334 16710414 17323924 19787249 20068231 21269460 7811265 7918633 NA PSB2 1 Proteasome subunit beta type-2 3.4.25.1 Macropain subunit C7-I Multicatalytic endopeptidase complex subunit C7-I Proteasome component C7-I gene 7973 1.0 C - Cellular Fate and Organization transcriptional repressor complex IEA PML body IEA nucleus IC lung development IEA embryonic skeletal development IEA embryonic placenta development IEA trophectodermal cell differentiation IEA enucleate erythrocyte differentiation IEA embryonic eye morphogenesis (sensu Actinopterygii) IEA liver development IEA ossification IEA T cell differentiation IEA megakaryocyte differentiation IEA B cell differentiation IEA natural killer cell differentiation IEA monocyte differentiation IEA granulocyte differentiation IEA positive regulation of transcription, DNA-dependent IDA negative regulation of transcription, DNA-dependent IMP double-stranded DNA binding IEA chromatin binding IEA zinc ion binding IEA Transcription factor Sp3; SPR-2 10391891 11812829 12176973 12297010 12411611 12419227 12837748 1341900 1454515 14702039 15247228 15474306 15489334 15494207 15554904 16781829 17548428 18187045 18617891 18669648 19690332 20068231 21406692 21746878 9278495 NA SP3 0 Transcription factor Sp3 SPR-2 TF 10325 1.0 SP1 C - Cellular Fate and Organization cytoplasm IEA nucleoplasm TAS transcription initiation from RNA polymerase II promoter TAS lung development IEA embryonic skeletal development IEA embryonic placenta development IEA trophectodermal cell differentiation IEA enucleate erythrocyte differentiation IEA embryonic eye morphogenesis (sensu Actinopterygii) IEA liver development IEA ossification IEA virus-host interaction IEA megakaryocyte differentiation IEA positive regulation of transcription from RNA polymerase II promoter IDA transforming growth factor beta receptor signaling pathway TAS double-stranded DNA binding IDA transcription factor activity IDA bHLH transcription factor binding ISS zinc ion binding IEA protein homodimerization activity IDA Transcription factor Sp1 10391891 10973950 10976766 11371615 11904305 12021324 12847090 12855699 14593115 15489334 15691849 16332679 16377629 16407261 16478997 16943418 16964243 17049555 18171990 18199680 18239466 18258854 18513490 18619531 18669648 19106100 19193796 19285002 19302979 19666599 20068231 20091743 20121949 21269460 21406692 21746878 3139301 3142690 3319186 7592727 8626793 9065444 9343410 9466902 NA SP1 0 Transcription factor Sp1 TF 1291 0.0816080920104172 CLDN5 C - Cellular Fate and Organization Schmidt-Lanterman cleft IEA plasma membrane IEA tight junction ISS integral to membrane TAS calcium-independent cell-cell adhesion ISS myelination IEA structural molecule activity IEA identical protein binding ISS Claudin-5; Transmembrane protein deleted in VCFS; TMDVCF 10591208 14702039 15461802 15489334 9192844 NA CLD5 -1 Claudin-5 Transmembrane protein deleted in VCFS TMDVCF gene 2634 1.33498047652627E-5 CLDN4 C - Cellular Fate and Organization apical plasma membrane IEA basal plasma membrane IEA integral to plasma membrane TAS tight junction ISS lateral plasma membrane IEA apicolateral plasma membrane IEA pregnancy IEA calcium-independent cell-cell adhesion ISS structural molecule activity IEA identical protein binding ISS transmembrane receptor activity TAS Claudin-4; Clostridium perfringens enterotoxin receptor; CPE-R; CPE-receptor; Williams-Beuren syndrome chromosomal region 8 protein 15489334 16236711 21269460 9334247 NA CLD4 1 Claudin-4 Clostridium perfringens enterotoxin receptor CPE-R CPE-receptor Williams-Beuren syndrome chromosomal region 8 protein gene 1291 0.00550844870783072 ADAM8 C - Cellular Fate and Organization cell surface IDA integral to plasma membrane IDA specific granule IDA dense core granule membrane IDA phagolysosome IDA positive regulation of protein kinase B signaling cascade ISS regulation of cell-cell adhesion IDA positive regulation of membrane protein ectodomain proteolysis IDA leukocyte migration during inflammatory response ISS positive regulation of protein secretion IC angiogenesis ISS positive regulation of cell adhesion ISS cell morphogenesis ISS cell-cell adhesion IEA negative regulation of neuron apoptosis ISS activation of NF-kappaB transcription factor ISS positive regulation of acute inflammatory response ISS positive regulation of bone resorption ISS proteolysis IEA lymphocyte chemotaxis ISS calcium ion binding ISS zinc ion binding TAS metalloendopeptidase activity IEA protein self-association TAS metallopeptidase activity IDA Disintegrin and metalloproteinase domain-containing protein 8; ADAM 8; 3.4.24.-; Cell surface antigen MS2; CD156a; Precursor 14702039 15164054 15489334 15574124 22684055 9126482 NA ADAM8 1 Disintegrin and metalloproteinase domain-containing protein 8 ADAM 8 3.4.24.- Cell surface antigen MS2 CD156a Precursor gene 1291 5.44352849390009E-6 RCBTB2 C - Cellular Fate and Organization Ran guanyl-nucleotide exchange factor activity TAS RCC1 and BTB domain-containing protein 2; Chromosome condensation 1-like; CHC1-L; RCC1-like G exchanging factor; Regulator of chromosome condensation and BTB domain-containing protein 2 14702039 15057823 15489334 9806834 NA RCBT2 -1 RCC1 and BTB domain-containing protein 2 Chromosome condensation 1-like CHC1-L RCC1-like G exchanging factor Regulator of chromosome condensation and BTB domain-containing protein 2 gene 1291 0.0449492875329337 EIF4E2 P - Translation mRNA cap complex IDA cytosol TAS cytokine and chemokine mediated signaling pathway TAS regulation of translation IEA RNA cap binding TAS translation initiation factor activity IEA translation factor activity, nucleic acid binding TAS Eukaryotic translation initiation factor 4E type 2; eIF-4E type 2; eIF4E type 2; Eukaryotic translation initiation factor 4E homologous protein; Eukaryotic translation initiation factor 4E-like 3; eIF4E-like protein 4E-LP; mRNA cap-binding protein 4EHP; mRNA cap-binding protein type 3 14623119 15153109 15489334 17368478 19608861 21269460 9582349 9653160 NA IF4E2 1 Eukaryotic translation initiation factor 4E type 2 eIF-4E type 2 eIF4E type 2 Eukaryotic translation initiation factor 4E homologous protein Eukaryotic translation initiation factor 4E-like 3 eIF4E-like protein 4E-LP mRNA cap-binding protein 4EHP mRNA cap-binding protein type 3 gene 1291 0.117179770282665 SUV39H2 D - Genome Maintenance nuclear heterochromatin IEA chromatin IDA chromosome, pericentric region IEA regulation of transcription, DNA-dependent IEA chromatin remodeling IDA transcription, DNA-dependent IEA cell differentiation IEA male meiosis IEA chromatin assembly or disassembly IMP chromatin binding IEA histone lysine N-methyltransferase activity (H3-K9 specific) IDA zinc ion binding IEA Histone-lysine N-methyltransferase SUV39H2; 2.1.1.43; Histone H3-K9 methyltransferase 2; H3-K9-HMTase 2; Lysine N-methyltransferase 1B; Suppressor of variegation 3-9 homolog 2; Su(var)3-9 homolog 2 14702039 14765126 15107829 15164054 15489334 16959974 17974005 18669648 21406692 NA SUV92 1 Histone-lysine N-methyltransferase SUV39H2 2.1.1.43 Histone H3-K9 methyltransferase 2 H3-K9-HMTase 2 Lysine N-methyltransferase 1B Suppressor of variegation 3-9 homolog 2 Su(var)3-9 homolog 2 gene 1291 0.015193707803644 CD69 A - Transport and Sensing integral to plasma membrane TAS external side of plasma membrane IEA carbohydrate binding IEA transmembrane receptor activity TAS Early activation antigen CD69; Activation inducer molecule; AIM; BL-AC/P26; C-type lectin domain family 2 member C; EA1; Early T-cell activation antigen p60; GP32/28; Leukocyte surface antigen Leu-23; MLR-3; CD69 11036086 11101293 15489334 18959746 8026529 8100776 8340758 8496594 NA CD69 -1 Early activation antigen CD69 Activation inducer molecule AIM BL-AC/P26 C-type lectin domain family 2 member C EA1 Early T-cell activation antigen p60 GP32/28 Leukocyte surface antigen Leu-23 MLR-3 CD69 gene 1899 3.03122960232047E-4 PLCE1 C - Cellular Fate and Organization Golgi membrane IEA plasma membrane IDA cytosol IDA calcium-mediated signaling NAS cell proliferation NAS inositol phosphate-mediated signaling TAS G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) IDA Ras protein signal transduction TAS regulation of Ras protein signal transduction IDA regulation of smooth muscle contraction TAS regulation of cell growth TAS elevation of cytosolic calcium ion concentration TAS glomerulus development IMP protein kinase C activation NAS lipid catabolic process IEA heart development TAS activation of MAPK activity IDA regulation of G-protein coupled receptor protein signaling pathway IDA epidermal growth factor receptor signaling pathway NAS cytoskeleton organization and biogenesis NAS diacylglycerol biosynthetic process TAS phospholipid metabolic process IC guanyl-nucleotide exchange factor activity TAS phosphoinositide phospholipase C activity IDA calcium ion binding IEA receptor signaling protein activity TAS Ras GTPase binding TAS 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; 3.1.4.11; Pancreas-enriched phospholipase C; Phosphoinositide phospholipase C-epsilon-1; Phospholipase C-epsilon-1; PLC-epsilon-1 10819331 11022047 11022048 11395506 11715024 11877431 12444546 12721365 14702039 15157671 15164054 15489334 15558028 16293787 16483931 16537651 17086182 NA PLCE1 -1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 3.1.4.11 Pancreas-enriched phospholipase C Phosphoinositide phospholipase C-epsilon-1 Phospholipase C-epsilon-1 PLC-epsilon-1 gene 1291 0.0381457414750155 NUPL2 A - Transport and Sensing nuclear membrane IEA nuclear pore IEA nucleus TAS cytosol TAS glucose transport TAS carbohydrate metabolic process TAS cytokine and chemokine mediated signaling pathway TAS viral reproduction TAS mRNA transport IEA nuclear export signal receptor activity TAS zinc ion binding IEA nucleic acid binding IEA Nucleoporin-like protein 2; NLP-1; NUP42 homolog; Nucleoporin hCG1 10228171 10358091 10610322 12228227 12690205 14702039 15489334 16000379 18669648 20068231 9450185 NA NUPL2 1 Nucleoporin-like protein 2 NLP-1 NUP42 homolog Nucleoporin hCG1 gene 1291 0.068148169631386 C - Cellular Fate and Organization cytoplasm IDA nucleus IDA positive regulation of caspase activity IDA endoderm formation IDA negative regulation of cell proliferation IDA positive regulation of transcription, DNA-dependent IEA negative regulation of transcription, DNA-dependent IDA sequence-specific DNA binding IEA transcription factor activity IDA RNA polymerase II transcription factor activity, enhancer binding IEA Transcription factor SOX-7 11691915 14702039 15489334 18819930 NA SOX7 -1 Transcription factor SOX-7 gene 1291 0.0550793834643225 SLC50A1 D - Genome Maintenance Golgi apparatus IDA Golgi membrane IEA plasma membrane IDA nucleus IC integral to membrane IEA endomembrane system ISS positive regulation of gene expression, epigenetic ISS carbohydrate transport IEA DNA recombination IEA glucoside transporter activity IDA Sugar transporter SWEET1; HsSWEET1; RAG1-activating protein 1; Solute carrier family 50 member 1; Stromal cell protein 10931946 14702039 15489334 16710414 21107422 NA SWET1 1 Sugar transporter SWEET1 HsSWEET1 RAG1-activating protein 1 Solute carrier family 50 member 1 Stromal cell protein gene 1291 0.228382662965278 D - Genome Maintenance mitochondrion IDA nucleus IDA negative regulation of apoptosis IMP positive regulation of cell proliferation IMP positive regulation of apoptosis IMP negative regulation of cell proliferation IMP spinal cord motor neuron differentiation ISS protein stabilization IMP positive regulation of protein biosynthetic process IMP sympathetic nervous system development ISS neural tube formation ISS glial cell proliferation ISS negative regulation of protein export from nucleus IMP skeletal development ISS glial cell development ISS T cell differentiation ISS DNA damage response, detection of DNA damage IDA endocrine pancreas development IEA positive regulation of insulin secretion ISS pro-B cell differentiation ISS negative regulation of protein ubiquitination IMP somatic stem cell maintenance IEA DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IMP Transcription factor SOX-4 14574404 15489334 1614875 16631117 8268656 NA SOX4 1 Transcription factor SOX-4 gene 15102 1.0 D - Genome Maintenance transcription factor complex TAS cytosol IDA adenohypophysis development IEA cerebral cortex development IEA eye development IEP pituitary gland development IEP negative regulation of epithelial cell proliferation IDA establishment and/or maintenance of chromatin architecture NAS glial cell fate commitment NAS endodermal cell fate specification IDA male genitalia development IEA positive regulation of epithelial cell differentiation IEA diencephalon morphogenesis IEA positive regulation of transcription from RNA polymerase II promoter IDA cell cycle arrest IDA somatic stem cell maintenance IDA positive regulation of Notch signaling pathway IEA olfactory placode formation IEA inner ear development IEP inner ear morphogenesis IEA alveolus development IEA forebrain neuron differentiation IEA response to wounding IEP positive regulation of neuroblast proliferation IEA negative regulation of transcription from RNA polymerase II promoter ISS neuron fate commitment IEA osteoblast differentiation IDA regulation of caspase activity IDA negative regulation of osteoblast differentiation IEA negative regulation of neuron differentiation ISS positive regulation of neuron differentiation IEA detection of mechanical stimulus during sensory perception of sound IEA pigment biosynthetic process IEA detection of mechanical stimulus during equilibrioception IEA positive regulation of MAPKKK cascade IDA tongue development IEA sequence-specific DNA binding IDA miRNA binding IDA transcription factor activity IDA chromatin binding IEA Transcription factor SOX-2 12612584 15489334 18035408 21406692 7849401 NA SOX2 0 Transcription factor SOX-2 TF 1291 0.0886312797080639 SETBP1 N - Not Matched nucleus IEA DNA binding IEA SET-binding protein; SEB 11231286 12168954 15489334 16177791 16959974 19690332 20436468 9455477 NA SETBP -1 SET-binding protein SEB gene 1291 0.00278859755477853 CD59 C - Cellular Fate and Organization sarcolemma IEA compact myelin IEA extracellular space IEA anchored to external side of plasma membrane IDA negative regulation of apoptosis IEA blood coagulation TAS negative regulation of activation of membrane attack complex IEA positive regulation of T cell proliferation IEA cell surface receptor linked signal transduction TAS CD59 glycoprotein; 1F5 antigen; 20 kDa homologous restriction factor; HRF-20; HRF20; MAC-inhibitory protein; MAC-IP; MEM43 antigen; Membrane attack complex inhibition factor; MACIF; Membrane inhibitor of reactive lysis; MIRL; Protectin; CD59; Precursor 10805801 1377690 1381503 1382994 1383553 14517339 15489334 16602701 1689664 1692709 17566972 18780401 21269460 2475111 2475570 2476718 2606909 7512825 7520819 8276756 8670172 9053451 9054419 9235986 NA CD59 -1 CD59 glycoprotein 1F5 antigen 20 kDa homologous restriction factor HRF-20 HRF20 MAC-inhibitory protein MAC-IP MEM43 antigen Membrane attack complex inhibition factor MACIF Membrane inhibitor of reactive lysis MIRL Protectin CD59 Precursor gene 1291 0.0321939181165794 PITPNA A - Transport and Sensing cytoplasm IEA lipid metabolic process NAS axon guidance TAS visual perception TAS phosphatidylinositol transporter activity TAS phosphatidylcholine transporter activity TAS phosphoinositide binding IEA acyl-CoA binding IEA Phosphatidylinositol transfer protein alpha isoform; PI-TP-alpha; PtdIns transfer protein alpha; PtdInsTP alpha 14962392 15489334 19608861 21269460 8194769 NA PIPNA -1 Phosphatidylinositol transfer protein alpha isoform PI-TP-alpha PtdIns transfer protein alpha PtdInsTP alpha gene 1531 0.0121869290946382 D - Genome Maintenance integral to plasma membrane IDA mitochondrial inner membrane TAS nucleoplasm IDA DNA replication IEA progesterone receptor signaling pathway IDA histone deacetylation IDA negative regulation of cell growth IMP negative regulation of cell proliferation IMP regulation of apoptosis TAS negative regulation of transcription from RNA polymerase II promoter IDA positive regulation of transcription, DNA-dependent IDA Prohibitin 11302691 1540973 15489334 19608861 21269460 21746876 8244394 NA PHB 1 Prohibitin gene 1291 0.205578617641417 DAZAP2 N - Not Matched cytoplasm IEA nucleus IEA DAZ-associated protein 2; Deleted in azoospermia-associated protein 2 10857750 14702039 15489334 16541075 17935665 22070932 22771904 7584044 NA DAZP2 -1 DAZ-associated protein 2 Deleted in azoospermia-associated protein 2 gene 1512 0.00298885354381607 FAM63B Protein FAM63B 10574461 14702039 15489334 18669648 NA FA63B -1 Protein FAM63B gene 1291 4.71216325971068E-4 C - Cellular Fate and Organization integral to plasma membrane TAS extracellular region TAS integral to membrane TAS extracellular space TAS insulin receptor signaling pathway TAS acute inflammatory response IEA energy reserve metabolic process IEA positive regulation of bone mineralization IMP carbohydrate metabolic process IEA fibroblast growth factor receptor signaling pathway TAS aging IMP beta-glucuronidase activity IEA cation binding IEA vitamin D binding IEA signal transducer activity TAS beta-glucosidase activity TAS Klotho; 3.2.1.31; Klotho peptide; Precursor 10631108 11043382 11162628 11792841 15057823 15135068 15677572 16959974 17710231 9363890 9464267 NA KLOT -1 Klotho 3.2.1.31 Klotho peptide Precursor gene 3206 1.0 MAZ T - Transcription nucleus IEA transcription termination from RNA polymerase II promoter IDA regulation of transcription, DNA-dependent IEA transcription initiation from RNA polymerase II promoter IDA RNA binding IEA zinc ion binding IEA Myc-associated zinc finger protein; MAZI; Pur-1; Purine-binding transcription factor; Serum amyloid A-activating factor-1; SAF-1; Transcription factor Zif87; ZF87; Zinc finger protein 801 10727212 12270922 1502157 15616553 1567856 20068231 21269460 21406692 8626793 8831693 9685418 NA MAZ 0 Myc-associated zinc finger protein MAZI Pur-1 Purine-binding transcription factor Serum amyloid A-activating factor-1 SAF-1 Transcription factor Zif87 ZF87 Zinc finger protein 801 TF 1291 0.0425429100466392 HEG1 N - Not Matched intercellular junction IEA extracellular region IEA integral to membrane IEA external side of plasma membrane IEA body growth IEA endothelial cell morphogenesis IEA lung development IEA venous blood vessel morphogenesis IEA post-embryonic development IEA vasculogenesis IEA embryonic development (sensu Mammalia) IEA lymph vessel development IEA intercellular junction assembly and maintenance IEA regulation of body fluids IEA calcium ion binding IEA Protein HEG homolog 1; Precursor 10574462 14702039 15489334 16335952 16641997 22171320 23007647 NA HEG1 -1 Protein HEG homolog 1 Precursor gene 1291 7.32214560611605E-4 FTO N - Not Matched nucleus ISS thermoregulation IEA DNA dealkylation IDA regulation of body size IEA RNA repair IDA oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA ferrous iron binding IDA Alpha-ketoglutarate-dependent dioxygenase FTO; 1.14.11.-; Fat mass and obesity-associated protein 11214970 15489334 15616553 17434869 17496892 18775698 19559399 19608861 20376003 21269460 NA FTO -1 Alpha-ketoglutarate-dependent dioxygenase FTO 1.14.11.- Fat mass and obesity-associated protein gene 1291 0.00414069547142654 RAB11FIP1 A - Transport and Sensing cytoplasm IDA phagocytic vesicle membrane IEA intracellular membrane-bound organelle IDA protein transport IEA Rab11 family-interacting protein 1; Rab11-FIP1; Rab-coupling protein 11495908 11786538 11944901 14702039 15181150 15280022 15355514 15489334 18669648 18691976 19690332 20068231 21269460 21406692 NA RFIP1 -1 Rab11 family-interacting protein 1 Rab11-FIP1 Rab-coupling protein gene 2240 0.0206031870155919 PPAT D - Genome Maintenance cytosol TAS purine ribonucleoside monophosphate biosynthetic process TAS kidney development IEA organ regeneration IEA G1/S transition of mitotic cell cycle IEA lactation IEA purine base metabolic process TAS protein homotetramerization IEA glutamine catabolic process IEA nucleoside metabolic process IEA purine base biosynthetic process IEA purine nucleotide biosynthetic process TAS 'de novo' IMP biosynthetic process IEA 4 iron, 4 sulfur cluster binding IEA amidophosphoribosyltransferase activity TAS metal ion binding IEA Amidophosphoribosyltransferase; ATase; 2.4.2.14; Glutamine phosphoribosylpyrophosphate amidotransferase; GPAT; Precursor 15489334 21269460 8106516 8380692 NA PUR1 1 Amidophosphoribosyltransferase ATase 2.4.2.14 Glutamine phosphoribosylpyrophosphate amidotransferase GPAT Precursor gene 1349 7.06952309527374E-4 PGR C - Cellular Fate and Organization cytoplasm IEA nucleoplasm TAS progesterone receptor signaling pathway IEA regulation of epithelial cell proliferation IEA transcription initiation from RNA polymerase II promoter TAS cell-cell signaling TAS epithelial cell maturation IEA ovulation (sensu Mammalia) IEA sequence-specific DNA binding IEA steroid hormone receptor activity TAS zinc ion binding IEA ligand-dependent nuclear receptor activity IEA steroid binding IEA DNA binding TAS Progesterone receptor; PR; Nuclear receptor subfamily 3 group C member 3 10628747 10655479 11110801 12039952 12917342 15572662 15798179 15937332 16478993 16554811 17020914 17173941 17347654 17717077 18202149 18375150 22031296 2328727 3551956 7476977 8702648 9171245 9620806 NA PRGR -1 Progesterone receptor PR Nuclear receptor subfamily 3 group C member 3 gene 1291 0.443742622063426 GAB2 C - Cellular Fate and Organization plasma membrane IDA cytosol TAS positive regulation of cell proliferation IDA phosphoinositide-mediated signaling ISS osteoclast differentiation IMP positive regulation of mast cell degranulation ISS phosphatidylinositol-3,4-bisphosphate binding ISS phosphatidylinositol-3,4,5-triphosphate binding ISS transmembrane receptor protein tyrosine kinase adaptor protein activity IDA GRB2-associated-binding protein 2; GRB2-associated binder 2; Growth factor receptor bound protein 2-associated protein 2; pp100 10068651 15010462 15489334 15750601 16554811 18669648 19172738 19523899 19690332 21269460 9628581 NA GAB2 -1 GRB2-associated-binding protein 2 GRB2-associated binder 2 Growth factor receptor bound protein 2-associated protein 2 pp100 gene 1291 1.00753096415065E-7 SLC2A3 A - Transport and Sensing plasma membrane TAS integral to membrane IEA L-ascorbic acid metabolic process TAS glucose transporter activity TAS Solute carrier family 2, facilitated glucose transporter member 3; Glucose transporter type 3, brain; GLUT-3 14702039 15489334 3170580 9477959 NA GTR3 -1 Solute carrier family 2, facilitated glucose transporter member 3 Glucose transporter type 3, brain GLUT-3 gene 3861 0.112246793770588 SLC2A1 A - Transport and Sensing basolateral plasma membrane IEA melanosome IEA female pronucleus IEA plasma membrane TAS intercellular junction IEA caveola IEA midbody IDA integral to membrane IEA L-ascorbic acid metabolic process TAS energy reserve metabolic process TAS regulation of insulin secretion TAS response to osmotic stress IEA cellular response to glucose starvation IEA xenobiotic transporter activity IEA glucose transporter activity TAS Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1; HepG2 glucose transporter 10227690 10980529 11136715 11603379 12325075 14605501 14702039 15489334 15622525 17081065 18451999 18691976 19349973 19630075 19798636 19901175 20068231 20129935 20221955 20574033 20621801 20830593 21204808 21269460 21406692 21832227 22282645 2834252 3839598 NA GTR1 1 Solute carrier family 2, facilitated glucose transporter member 1 Glucose transporter type 1, erythrocyte/brain GLUT-1 HepG2 glucose transporter gene 1291 0.015193707803644 MSR1 A - Transport and Sensing collagen IEA integral to plasma membrane TAS cytoplasmic vesicle IEA cytosol IEA lipoprotein transport IEA cholesterol transport ISS response to chemical stimulus IEA low-density lipoprotein binding ISS scavenger receptor activity TAS Macrophage scavenger receptor types I and II; Macrophage acetylated LDL receptor I and II; Scavenger receptor class A member 1; CD204 12244320 14759258 15489334 16421571 19159218 21791690 2251254 8093617 8900177 9548586 NA MSRE -1 Macrophage scavenger receptor types I and II Macrophage acetylated LDL receptor I and II Scavenger receptor class A member 1 CD204 gene 1291 0.223079106692603 PGAP1 A - Transport and Sensing endoplasmic reticulum membrane TAS intrinsic to endoplasmic reticulum membrane IEA integral to membrane IEA C-terminal protein lipidation TAS embryonic pattern specification IEA anterior/posterior axis specification IEA sensory perception of sound IEA attachment of GPI anchor to protein TAS intracellular protein transport IEA myo-inositol transport ISS forebrain regionalization IEA phosphoric ester hydrolase activity ISS nuclease activity ISS GPI inositol-deacylase; 3.1.-.-; Post-GPI attachment to proteins factor 1; hPGAP1 12975309 14702039 14734546 15489334 15815621 17974005 NA PGAP1 -1 GPI inositol-deacylase 3.1.-.- Post-GPI attachment to proteins factor 1 hPGAP1 gene 1291 0.0474423100358454 WDR47 C - Cellular Fate and Organization cytoplasm IEA microtubule IEA multicellular organismal development IEA WD repeat-containing protein 47; Neuronal enriched MAP interacting protein; Nemitin 10048485 14702039 15489334 16710414 18220336 18669648 20068231 NA WDR47 -1 WD repeat-containing protein 47 Neuronal enriched MAP interacting protein Nemitin gene 1291 0.122062164231375 C - Cellular Fate and Organization receptor complex IDA cell surface IDA integral to plasma membrane TAS lysosome TAS receptor internalization IDA regulation of G-protein coupled receptor protein signaling pathway IEA G-protein coupled receptor protein signaling pathway IEA positive regulation of receptor recycling IDA calcium ion transport IDA intracellular protein transport IEA negative regulation of transcription, DNA-dependent IMP protein transporter activity IDA receptor activity IDA coreceptor activity IEA Receptor activity-modifying protein 3; Calcitonin-receptor-like receptor activity-modifying protein 3; CRLR activity-modifying protein 3; Precursor 12853948 15489334 9620797 NA RAMP3 -1 Receptor activity-modifying protein 3 Calcitonin-receptor-like receptor activity-modifying protein 3 CRLR activity-modifying protein 3 Precursor gene 1291 0.00914305577801058 Protein FAM98A 14702039 15489334 15815621 17974005 21269460 NA FA98A 1 Protein FAM98A gene 1291 0.160728659329178 C - Cellular Fate and Organization endoplasmic reticulum lumen TAS collagen type V IMP skeletal development IEA axon guidance TAS collagen fibril organization IMP skin development IMP eye morphogenesis IMP metal ion binding IEA extracellular matrix structural constituent IEA Collagen alpha-2(V) chain; Precursor 11566270 11940702 15489334 1571108 15815621 1820205 21757687 2411731 2914927 2985598 3029669 3224983 3858826 8181482 9425231 9783710 NA CO5A2 1 Collagen alpha-2(V) chain Precursor gene 1892 3.69471430987001E-4 MFAP3L N - Not Matched plasma membrane IEA integral to membrane IEA Microfibrillar-associated protein 3-like; Testis development protein NYD-SP9; Precursor 14702039 15489334 15815621 9734811 NA MFA3L -1 Microfibrillar-associated protein 3-like Testis development protein NYD-SP9 Precursor gene 1291 0.181822379588751 C - Cellular Fate and Organization endoplasmic reticulum lumen TAS collagen type V IMP basement membrane IEA heart morphogenesis IEA blood vessel development IEA wound healing, spreading of epidermal cells IMP axon guidance TAS collagen fibril organization IMP regulation of cell organization and biogenesis IEA skin development IMP integrin biosynthetic process IMP eye morphogenesis IMP fibril organization and biogenesis IMP cell adhesion IMP integrin binding NAS platelet-derived growth factor binding IDA heparin binding IDA metal ion binding IEA extracellular matrix structural constituent IEA Collagen alpha-1(V) chain; Precursor 10471441 10602121 11992482 15164053 15580559 1571108 1722213 18972565 2071595 21248752 2203476 2496661 8181482 9042913 9099729 NA CO5A1 1 Collagen alpha-1(V) chain Precursor gene 1291 0.00675092610057069 MT2A N - Not Matched perinuclear region ISS nucleus ISS cytosol TAS copper ion homeostasis TAS negative regulation of growth ISS drug binding IDA zinc ion binding IDA Metallothionein-2; MT-2; Metallothionein-2A; Metallothionein-II; MT-II 1339282 15489334 1593628 2388267 2780570 6896577 7133118 913597 NA MT2 -1 Metallothionein-2 MT-2 Metallothionein-2A Metallothionein-II MT-II gene 1291 0.0409712296333968 C - Cellular Fate and Organization cytoplasm IEA terminal button IEA actin cytoskeleton NAS actin cytoskeleton organization and biogenesis IEA positive regulation of actin filament polymerization IEA regulation of actin polymerization and/or depolymerization NAS negative regulation of actin filament polymerization IEA phosphatidylinositol-4,5-bisphosphate binding NAS actin binding NAS Profilin-2; Profilin II 10600384 11027290 14702039 15489334 21269460 7758455 8365484 NA PROF2 -1 Profilin-2 Profilin II gene 1291 5.81161821789828E-5 SSFA2 N - Not Matched cytoplasm IEA plasma membrane NAS Sperm-specific antigen 2; Cleavage signal-1 protein; CS-1; Ki-ras-induced actin-interacting protein 11572484 14673706 14702039 15489334 1555770 15815621 17081983 17974005 18669648 19369195 19690332 20068231 NA SSFA2 -1 Sperm-specific antigen 2 Cleavage signal-1 protein CS-1 Ki-ras-induced actin-interacting protein gene 1291 0.00955317868538724 GINS2 D - Genome Maintenance nucleoplasm TAS S phase of mitotic cell cycle TAS DNA strand elongation during DNA replication TAS DNA replication complex GINS protein PSF2; GINS complex subunit 2 10810093 11042152 14702039 15489334 17417653 17525332 17545466 17557111 17652513 18669648 19690332 20068231 21269460 21406692 NA PSF2 1 DNA replication complex GINS protein PSF2 GINS complex subunit 2 gene 1291 0.00834791357145082 SIPA1L3 C - Cellular Fate and Organization intracellular IEA positive regulation of GTPase activity IEA regulation of small GTPase mediated signal transduction IEA GTPase activator activity IEA Signal-induced proliferation-associated 1-like protein 3; SIPA1-like protein 3; SPA-1-like protein 3 12168954 18669648 19608861 19690332 9628581 NA SI1L3 1 Signal-induced proliferation-associated 1-like protein 3 SIPA1-like protein 3 SPA-1-like protein 3 gene 1291 0.0882021116002911 GINS1 D - Genome Maintenance cytoplasm IDA nucleoplasm TAS S phase of mitotic cell cycle TAS DNA strand elongation during DNA replication TAS inner cell mass cell proliferation IEA DNA replication complex GINS protein PSF1; GINS complex subunit 1 11780052 15489334 17417653 17545466 17557111 17611626 17652513 21269460 8724849 NA PSF1 1 DNA replication complex GINS protein PSF1 GINS complex subunit 1 gene 1857 0.00385421984586471 YY1 D - Genome Maintenance PcG protein complex IEA transcription factor complex IEA INO80 complex IDA plasma membrane IDA nuclear matrix IEA response to UV-C IMP chromosome organization and biogenesis IEA double-strand break repair via homologous recombination IMP spermatogenesis IEA eye morphogenesis (sensu Vertebrata) IEA anterior/posterior pattern formation IEA RNA localization IEA cell differentiation IEA four-way junction DNA binding IDA transcription corepressor activity TAS RNA binding IDA transcription coactivator activity TAS zinc ion binding TAS Transcriptional repressor protein YY1; Delta transcription factor; INO80 complex subunit S; NF-E1; Yin and yang 1; YY-1 11158321 11437367 15489334 16314846 1655281 17721549 18026119 18669648 18691976 18922472 18950698 1946405 19690332 20068231 21076407 21269460 21303910 21406692 8942976 9016636 9493912 9642075 NA TYY1 1 Transcriptional repressor protein YY1 Delta transcription factor INO80 complex subunit S NF-E1 Yin and yang 1 YY-1 TF 1913 0.0947091236009375 ERI2 D - Genome Maintenance intracellular IEA exonuclease activity IEA zinc ion binding IEA nucleic acid binding IEA ERI1 exoribonuclease 2; 3.1.-.-; Exonuclease domain-containing protein 1 10493829 10819331 14702039 15489334 16959974 NA ERI2 1 ERI1 exoribonuclease 2 3.1.-.- Exonuclease domain-containing protein 1 gene 122344 0.973304229946361 reported -1 mir 1291 0.018030555180901 FRY C - Cellular Fate and Organization spindle pole IEA cytoplasm IEA microtubule organizing center IEA Protein furry homolog 15057823 19369195 19690332 22753416 NA FRY -1 Protein furry homolog gene 1291 0.0160033796822725 CD36 C - Cellular Fate and Organization phagocytic vesicle TAS Golgi apparatus IEA cell surface IDA integral to plasma membrane TAS platelet alpha granule membrane TAS lipid raft IEA external side of plasma membrane IEA positive regulation of interleukin-6 production IEA nitric oxide mediated signal transduction IDA defense response to Gram-positive bacterium IEA sequestering of lipid IMP positive regulation of peptidyl-tyrosine phosphorylation IEA positive regulation of interleukin-12 production IEA cholesterol transport ISS cGMP-mediated signaling IDA negative regulation of transcription factor import into nucleus IEA plasma membrane long-chain fatty acid transport IDA lipoprotein transport IMP positive regulation of I-kappaB kinase/NF-kappaB cascade IEA cell adhesion TAS cellular lipid metabolic process TAS positive regulation of tumor necrosis factor-alpha production IEA platelet activation TAS apoptotic cell clearance IEA negative regulation of transcription from RNA polymerase II promoter IEA phagocytosis, recognition IEA positive regulation of blood coagulation IEA platelet degranulation TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS positive regulation of MAPKKK cascade IEA cell surface receptor linked signal transduction IEA positive regulation of cell-matrix adhesion IDA low-density lipoprotein receptor activity IMP high-density lipoprotein binding IEA Gram-negative bacterial cell surface binding IEA transforming growth factor beta binding ISS Gram-positive bacterial cell surface binding IEA low-density lipoprotein binding IDA lipid binding IDA Platelet glycoprotein 4; Fatty acid translocase; FAT; Glycoprotein IIIb; GPIIIB; Leukocyte differentiation antigen CD36; PAS IV; PAS-4; Platelet collagen receptor; Platelet glycoprotein IV; GPIV; Thrombospondin receptor; CD36 10391209 10890433 11668637 11950861 12506336 1371676 15242332 15282206 15489334 16263699 18780401 19159218 2468669 2473841 7503937 7505064 7518447 7533783 7693552 8798390 NA CD36 -1 Platelet glycoprotein 4 Fatty acid translocase FAT Glycoprotein IIIb GPIIIB Leukocyte differentiation antigen CD36 PAS IV PAS-4 Platelet collagen receptor Platelet glycoprotein IV GPIV Thrombospondin receptor CD36 gene 1291 0.0118402561230045 AATK C - Cellular Fate and Organization mitochondrion IDA perinuclear region IEA integral to membrane IEA protein amino acid autophosphorylation IEA apoptosis IEA protein serine/threonine kinase activity IEA protein-tyrosine kinase activity IEA ATP binding IEA Serine/threonine-protein kinase LMTK1; 2.7.11.1; Apoptosis-associated tyrosine kinase; AATYK; Brain apoptosis-associated tyrosine kinase; CDK5-binding protein; Lemur tyrosine kinase 1; p35-binding protein; p35BP 10837911 12168954 14521924 14702039 15489334 17344846 9734811 NA LMTK1 -1 Serine/threonine-protein kinase LMTK1 2.7.11.1 Apoptosis-associated tyrosine kinase AATYK Brain apoptosis-associated tyrosine kinase CDK5-binding protein Lemur tyrosine kinase 1 p35-binding protein p35BP gene 1291 0.364504426934328 C - Cellular Fate and Organization apical plasma membrane ISS perinuclear region IDA basal plasma membrane ISS integral to plasma membrane TAS lysosome ISS external side of plasma membrane IDA intercellular bridge IDA glutamate metabolic process IDA positive regulation of interleukin-10 production IDA positive regulation of odontogenesis IDA negative regulation of tumor necrosis factor-alpha production IDA leukocyte migration ISS positive regulation of angiogenesis IDA signal transduction IEP cell-cell adhesion IDA tissue homeostasis IDA negative regulation of nitric oxide biosynthetic process IDA negative regulation of blood coagulation IDA endothelial cell proliferation IDA regulation of immune response TAS blood pressure regulation IDA carbohydrate binding IDA sulfate binding IEA Hematopoietic progenitor cell antigen CD34; CD34; Precursor 1370171 1374051 14702039 15489334 16710414 1694174 2462139 7678811 NA CD34 -1 Hematopoietic progenitor cell antigen CD34 CD34 Precursor gene 1374 1.76064085886393E-4 FNBP1 A - Transport and Sensing coated pit IEA plasma membrane IEA cytoplasmic membrane-bound vesicle IEA cytoskeleton IEA cell cortex IEA lysosome IEA endocytosis IEA lipid binding IEA Formin-binding protein 1; Formin-binding protein 17; hFBP17 11431473 11438682 12023017 14596906 14702039 15047863 15144186 15164053 15252009 15489334 16318909 16326391 16418535 16630611 16964243 17512409 18669648 19367720 19608861 19690332 20068231 21269460 21406692 9628581 NA FNBP1 -1 Formin-binding protein 1 Formin-binding protein 17 hFBP17 gene 1291 0.0816080920104172 ST6GALNAC6 F - Protein Fate cytoplasm ISS integral to Golgi membrane IEA plasma membrane NAS integral to membrane TAS glycosylceramide metabolic process IDA glycoprotein metabolic process IDA oligosaccharide biosynthetic process ISS cell-cell recognition IC ganglioside biosynthetic process ISS protein amino acid glycosylation IEA alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity ISS Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; 2.4.99.-; GalNAc alpha-2,6-sialyltransferase VI; ST6GalNAc VI; ST6GalNAcVI; hST6GalNAc VI; Sialyltransferase 7F; SIAT7-F 12668675 12975309 14702039 15164053 15489334 15843597 16207893 17123352 17760270 NA SIA7F -1 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 2.4.99.- GalNAc alpha-2,6-sialyltransferase VI ST6GalNAc VI ST6GalNAcVI hST6GalNAc VI Sialyltransferase 7F SIAT7-F gene 1291 5.81161821789828E-5 MSMO1 N - Not Matched plasma membrane TAS endoplasmic reticulum membrane TAS integral to membrane TAS cholesterol biosynthetic process TAS fatty acid metabolic process TAS fatty acid biosynthetic process IEA iron ion binding IEA C-4 methylsterol oxidase activity TAS Methylsterol monooxygenase 1; 1.14.13.72; C-4 methylsterol oxidase 14702039 15489334 15815621 21269460 8663358 NA MSMO1 -1 Methylsterol monooxygenase 1 1.14.13.72 C-4 methylsterol oxidase gene 1291 4.01310661322713E-4 ST6GALNAC5 F - Protein Fate integral to Golgi membrane IEA oligosaccharide biosynthetic process ISS glycosphingolipid biosynthetic process ISS protein amino acid glycosylation IEA alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity ISS Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; 2.4.99.-; GD1 alpha synthase; GalNAc alpha-2,6-sialyltransferase V; ST6GalNAc V; ST6GalNAcV; Sialyltransferase 7E; SIAT7-E 14702039 15489334 16710414 NA SIA7E -1 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 2.4.99.- GD1 alpha synthase GalNAc alpha-2,6-sialyltransferase V ST6GalNAc V ST6GalNAcV Sialyltransferase 7E SIAT7-E gene 82870 0.00588921677523368 novel 1 mir 1291 0.341099895440387 Coiled-coil domain-containing protein 69 14702039 15372022 NA CCD69 -1 Coiled-coil domain-containing protein 69 gene 1291 0.300262688080211 OLFML1 N - Not Matched extracellular region IEA Olfactomedin-like protein 1; Precursor 12975309 14702039 15340161 15489334 16554811 18708057 NA OLFL1 -1 Olfactomedin-like protein 1 Precursor gene 1291 0.0747763912235243 NCOA4 C - Cellular Fate and Organization nucleus TAS positive regulation of transcription, DNA-dependent NAS transcription, DNA-dependent IEA male gonad development TAS androgen receptor signaling pathway NAS transcription coactivator activity NAS androgen receptor binding NAS Nuclear receptor coactivator 4; NCoA-4; Androgen receptor coactivator 70 kDa protein; 70 kDa AR-activator; 70 kDa androgen receptor coactivator; Androgen receptor-associated protein of 70 kDa; Ret-activating protein ELE1 10347167 14702039 15164054 15489334 17974005 8187085 8290261 8643607 9892017 NA NCOA4 -1 Nuclear receptor coactivator 4 NCoA-4 Androgen receptor coactivator 70 kDa protein 70 kDa AR-activator 70 kDa androgen receptor coactivator Androgen receptor-associated protein of 70 kDa Ret-activating protein ELE1 gene 1907 0.050860863154566 INO80 D - Genome Maintenance INO80 complex IDA microtubule IEA mitotic sister chromatid segregation IMP double-strand break repair via homologous recombination IMP positive regulation of cell growth IMP positive regulation of transcription from RNA polymerase II promoter IMP chromatin remodeling IDA spindle assembly IMP cell division IEA alpha-tubulin binding IMP DNA binding IDA ATP binding IEA ATPase activity IDA DNA helicase activity IDA DNA helicase INO80; hINO80; 3.6.4.12; INO80 complex subunit A; Putative DNA helicase INO80 complex homolog 1 10574462 15489334 16230350 16298340 17721549 17974005 18026119 18669648 18922472 19608861 19690332 20237820 20687897 20855601 20971067 21303910 NA INO80 -1 DNA helicase INO80 hINO80 3.6.4.12 INO80 complex subunit A Putative DNA helicase INO80 complex homolog 1 gene 1498 0.0355829069477402 NCOA1 C - Cellular Fate and Organization nuclear chromatin IDA nucleoplasm TAS positive regulation of apoptosis IEA positive regulation of neuron differentiation IEA androgen receptor signaling pathway NAS cellular lipid metabolic process TAS positive regulation of transcription from RNA polymerase II promoter by galactose IDA ligand-dependent nuclear receptor transcription coactivator activity IDA chromatin binding IEA signal transducer activity IEA androgen receptor binding NAS DNA binding IEA histone acetyltransferase activity IEA Nuclear receptor coactivator 1; NCoA-1; 2.3.1.48; Class E basic helix-loop-helix protein 74; bHLHe74; Protein Hin-2; RIP160; Renal carcinoma antigen NY-REN-52; Steroid receptor coactivator 1; SRC-1 10449719 10508479 10567404 10594042 10660621 10722692 11250900 11698662 11773079 11831720 11864604 12039952 12138096 12529333 12917342 12954634 14757047 15313887 15367689 15489334 15815621 16606617 16957778 17116691 17525332 20068231 7481822 8754792 9223281 9223431 9296499 9427757 9575154 9744270 NA NCOA1 -1 Nuclear receptor coactivator 1 NCoA-1 2.3.1.48 Class E basic helix-loop-helix protein 74 bHLHe74 Protein Hin-2 RIP160 Renal carcinoma antigen NY-REN-52 Steroid receptor coactivator 1 SRC-1 gene 2244 3.11597142828092E-4 RECK F - Protein Fate plasma membrane IEA membrane TAS anchored to membrane IEA embryo implantation IEA extracellular matrix organization and biogenesis IEA blood vessel maturation IEA serine-type endopeptidase inhibitor activity IEA metalloendopeptidase inhibitor activity TAS Reversion-inducing cysteine-rich protein with Kazal motifs; hRECK; Suppressor of tumorigenicity 15 protein; Precursor 15164053 15489334 9789069 NA RECK -1 Reversion-inducing cysteine-rich protein with Kazal motifs hRECK Suppressor of tumorigenicity 15 protein Precursor gene 1291 0.0783685434449873 C - Cellular Fate and Organization endoplasmic reticulum membrane TAS integral to membrane IEA androgen biosynthetic process TAS sex differentiation IEA cell differentiation IEA sex determination NAS 3-oxo-5-alpha-steroid 4-dehydrogenase activity IDA electron carrier activity TAS cholestenone 5-alpha-reductase activity IEA 3-oxo-5-alpha-steroid 4-dehydrogenase 1; 1.3.1.22; SR type 1; Steroid 5-alpha-reductase 1; S5AR 1 10931946 11678334 14702039 15489334 1686016 2339109 NA S5A1 1 3-oxo-5-alpha-steroid 4-dehydrogenase 1 1.3.1.22 SR type 1 Steroid 5-alpha-reductase 1 S5AR 1 gene 1291 0.157678612058417 SAR1B C - Cellular Fate and Organization ER to Golgi transport vesicle membrane TAS endoplasmic reticulum membrane TAS cytosol TAS antigen processing and presentation of peptide antigen via MHC class I TAS antigen processing and presentation of exogenous peptide antigen via MHC class II TAS COPII coating of Golgi vesicle TAS intracellular protein transport IEA protein amino acid N-linked glycosylation via asparagine TAS GTPase activity TAS GTP binding IEA metal ion binding IEA GTP-binding protein SAR1b; GTP-binding protein B; GTBPB 12692552 15489334 17309654 19274794 21269460 NA SAR1B 1 GTP-binding protein SAR1b GTP-binding protein B GTBPB gene 1291 0.443742622063426 SAR1A C - Cellular Fate and Organization Golgi apparatus IEA sarcoplasmic reticulum IEA endoplasmic reticulum IDA ER to Golgi vesicle-mediated transport NAS intracellular protein transport IEA GTPase activity NAS GTP binding IEA GTP-binding protein SAR1a; COPII-associated small GTPase 10871277 11230166 15489334 17005010 18669648 20068231 21269460 NA SAR1A -1 GTP-binding protein SAR1a COPII-associated small GTPase gene 1291 0.0914604721306057 GORASP2 N - Not Matched Golgi apparatus IDA Golgi membrane IEA membrane TAS organelle organization and biogenesis IMP Golgi reassembly-stacking protein 2; GRS2; Golgi phosphoprotein 6; GOLPH6; Golgi reassembly-stacking protein of 55 kDa; GRASP55; p59 10487747 11101516 11408587 11739401 11739402 14702039 15489334 15815621 16964243 17081983 17607000 17974005 18669648 19361449 19690332 20068231 21269460 21406692 21515684 NA GORS2 1 Golgi reassembly-stacking protein 2 GRS2 Golgi phosphoprotein 6 GOLPH6 Golgi reassembly-stacking protein of 55 kDa GRASP55 p59 gene 1291 0.136068548786856 D - Genome Maintenance contractile ring IDA nucleus IEA cytokinesis IDA mitosis IEA septin ring assembly TAS regulation of exit from mitosis TAS phospholipid binding IEA actin binding IDA Actin-binding protein anillin 10931866 12479805 12637748 14702039 15489334 15496454 15616196 15800069 16040610 16129829 16203764 16357138 16964243 17924679 17974005 18220336 18669648 19608861 19690332 20068231 21269460 21406692 NA ANLN 1 Actin-binding protein anillin gene 1291 0.00298781153961145 PFKP C - Cellular Fate and Organization 6-phosphofructokinase complex NAS fructose 6-phosphate metabolic process IEA glycolysis NAS ATP binding IEA metal ion binding IEA 6-phosphofructokinase activity ISS 6-phosphofructokinase type C; 2.7.1.11; 6-phosphofructokinase, platelet type; Phosphofructo-1-kinase isozyme C; PFK-C; Phosphofructokinase 1; Phosphohexokinase 14702039 15164054 15489334 15592455 16964243 1834056 18669648 18691976 19608861 19690332 20068231 21269460 21406692 8117307 NA K6PP 1 6-phosphofructokinase type C 2.7.1.11 6-phosphofructokinase, platelet type Phosphofructo-1-kinase isozyme C PFK-C Phosphofructokinase 1 Phosphohexokinase gene 1291 0.122062164231375 NDNF C - Cellular Fate and Organization extracellular matrix ISS extracellular region IDA peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan ISS negative regulation of neuron apoptosis IDA extracellular matrix organization and biogenesis ISS cell growth IDA neuron migration IDA heparin binding ISS Protein NDNF; Neuron-derived neurotrophic factor; Precursor 12975309 14702039 15489334 20969804 NA NDNF -1 Protein NDNF Neuron-derived neurotrophic factor Precursor gene 1291 7.72294705747797E-4 HHIP C - Cellular Fate and Organization cytoplasm IEA cell surface IEA integral to plasma membrane ISS extracellular region IEA regulation of fibroblast growth factor receptor signaling pathway IEA carbohydrate metabolic process IEA skeletal morphogenesis ISS negative regulation of smoothened signaling pathway ISS dorsal/ventral pattern formation IEA neuroblast proliferation IEA smoothened signaling pathway IEA quinone binding IEA oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor IEA zinc ion binding IDA Hedgehog-interacting protein; HHIP; HIP; Precursor 11435703 11472839 12975309 14702039 15489334 15815621 19561609 19561611 NA HHIP -1 Hedgehog-interacting protein HHIP HIP Precursor gene 1291 0.157678612058417 CDCA7 C - Cellular Fate and Organization nucleus IDA regulation of transcription, DNA-dependent IEA regulation of cell proliferation IDA transcription, DNA-dependent IEA Cell division cycle-associated protein 7; Protein JPO1 11598121 12188893 14702039 15489334 15815621 15994934 16580749 17974005 21406692 NA CDCA7 1 Cell division cycle-associated protein 7 Protein JPO1 gene 1291 0.0394304743082529 NEDD9 D - Genome Maintenance spindle pole IEA cytoplasm TAS Golgi apparatus IEA spindle TAS nucleus TAS focal adhesion IEA cell cortex IEA lamellipodium IEA mitosis IEA integrin-mediated signaling pathway NAS cell adhesion NAS actin filament bundle formation NAS regulation of growth IEA cell division IEA Enhancer of filamentation 1; hEF1; CRK-associated substrate-related protein; CAS-L; CasL; Cas scaffolding protein family member 2; Neural precursor cell expressed developmentally down-regulated protein 9; NEDD-9; Renal carcinoma antigen NY-REN-12; p105; Enhancer of filamentation 1 p55 10502414 10508479 11054566 11827972 12522270 14574404 14702039 15144186 15489334 19539609 8668148 8879209 9020138 9360983 9497377 9584194 NA CASL -1 Enhancer of filamentation 1 hEF1 CRK-associated substrate-related protein CAS-L CasL Cas scaffolding protein family member 2 Neural precursor cell expressed developmentally down-regulated protein 9 NEDD-9 Renal carcinoma antigen NY-REN-12 p105 Enhancer of filamentation 1 p55 gene 1291 0.0146035958550651 D - Genome Maintenance nuclear chromatin ISS cytoplasm ISS cohesin complex IEA plasma membrane IDA mitotic chromosome condensation IMP G1/S transition of mitotic cell cycle IDA mitotic metaphase plate congression IMP double-strand break repair IMP mitotic sister chromatid cohesion IMP cell division IEA chromatin binding TAS Sororin; Cell division cycle-associated protein 5; p35 12188893 14702039 15489334 15837422 16964243 17081983 17349791 18220336 18669648 19690332 20068231 21111234 21406692 NA CDCA5 1 Sororin Cell division cycle-associated protein 5 p35 gene 1291 0.00341877596436688 HECA N - Not Matched respiratory tube development NAS Headcase protein homolog; hHDC 11696983 14574404 15489334 18669648 19690332 NA HDC -1 Headcase protein homolog hHDC gene 1291 9.22356489088168E-6 SAMHD1 R - Stress and Defence nucleus IDA immune response NAS defense response to virus IMP innate immune response IEA metabolic process IEA regulation of innate immune response IMP phosphoric diester hydrolase activity IEA RNA binding IDA metal ion binding IEA SAM domain and HD domain-containing protein 1; 3.1.4.-; Dendritic cell-derived IFNG-induced protein; DCIP; Monocyte protein 5; MOP-5 11064105 11230166 11780052 14702039 15489334 17081983 18546154 18669648 18691976 19369195 19525956 20068231 20842748 21204240 21269460 NA SAMH1 -1 SAM domain and HD domain-containing protein 1 3.1.4.- Dendritic cell-derived IFNG-induced protein DCIP Monocyte protein 5 MOP-5 gene 1291 6.17614106217859E-5 C - Cellular Fate and Organization plasma membrane TAS cell surface IEA extracellular region TAS lipid raft IEA anchored to membrane IEA extracellular space IEA endosome membrane TAS phagocytosis TAS positive regulation of endocytosis IEA Toll signaling pathway TAS inflammatory response IEA response to heat IEA positive regulation of tumor necrosis factor-alpha production IDA innate immune response TAS I-kappaB kinase/NF-kappaB cascade TAS apoptosis TAS positive regulation of cytokine secretion IEA lipopolysaccharide binding IDA peptidoglycan receptor activity TAS opsonin receptor activity TAS Monocyte differentiation antigen CD14; Myeloid cell-specific leucine-rich glycoprotein; CD14; Monocyte differentiation antigen CD14, urinary form; Monocyte differentiation antigen CD14, membrane-bound form; Precursor 15489334 16335952 18810425 19159218 19838169 23264655 2453848 2462937 2472171 2779588 3385210 NA CD14 1 Monocyte differentiation antigen CD14 Myeloid cell-specific leucine-rich glycoprotein CD14 Monocyte differentiation antigen CD14, urinary form Monocyte differentiation antigen CD14, membrane-bound form Precursor gene 1291 0.265873318267263 LRP1 C - Cellular Fate and Organization cytoplasm IEA coated pit IEA integral to plasma membrane ISS nucleus IEA regulation of phospholipase A2 activity ISS negative regulation of Wnt receptor signaling pathway ISS apoptotic cell clearance ISS receptor-mediated endocytosis IEA cholesterol metabolic process IEA calcium ion binding ISS receptor activity TAS protein complex binding IDA lipoprotein transporter activity NAS Prolow-density lipoprotein receptor-related protein 1; LRP-1; Alpha-2-macroglobulin receptor; A2MR; Apolipoprotein E receptor; APOER; CD91; Low-density lipoprotein receptor-related protein 1 85 kDa subunit; LRP-85; Low-density lipoprotein receptor-related protein 1 515 kDa subunit; LRP-515; Low-density lipoprotein receptor-related protein 1 intracellular domain; LRPICD; Precursor 10318830 10652313 11729193 11735395 11854294 11907044 12713657 12888553 15272003 15769472 1618748 16335952 16541075 16938309 16959974 1698775 1702392 17124247 19159218 2112085 21269460 2597675 3266596 7534747 9782078 NA LRP1 -1 Prolow-density lipoprotein receptor-related protein 1 LRP-1 Alpha-2-macroglobulin receptor A2MR Apolipoprotein E receptor APOER CD91 Low-density lipoprotein receptor-related protein 1 85 kDa subunit LRP-85 Low-density lipoprotein receptor-related protein 1 515 kDa subunit LRP-515 Low-density lipoprotein receptor-related protein 1 intracellular domain LRPICD Precursor gene 1291 0.00467601827977754 ANKS1A C - Cellular Fate and Organization neuron projection ISS cytoplasm IDA nucleus IDA neuron remodeling ISS ephrin receptor signaling pathway ISS substrate-bound cell migration ISS Ankyrin repeat and SAM domain-containing protein 1A; Odin 12439753 14574404 15489334 17875921 18088087 18669648 19690332 20068231 21269460 21406692 9039502 NA ANS1A -1 Ankyrin repeat and SAM domain-containing protein 1A Odin gene 3080 0.0677139781813563 MEIS2 C - Cellular Fate and Organization nucleus IEA transcription from RNA polymerase II promoter TAS negative regulation of myeloid cell differentiation ISS eye development IEA positive regulation of transcription from RNA polymerase II promoter IEA negative regulation of transcription from RNA polymerase II promoter TAS sequence-specific DNA binding IDA transcription factor activity NAS transcription corepressor activity TAS transcription factor binding ISS Homeobox protein Meis2; Meis1-related protein 1 10764806 11279116 14702039 15489334 16572171 19559479 20523026 20553494 21746878 9383298 NA MEIS2 -1 Homeobox protein Meis2 Meis1-related protein 1 gene 1291 0.0103440759589067 C - Cellular Fate and Organization transcription factor complex IEA lens morphogenesis (sensu Vertebrata) IEA negative regulation of neuron differentiation IEA negative regulation of myeloid cell differentiation ISS angiogenesis IEA sequence-specific DNA binding IEA chromatin binding IEA RNA polymerase II transcription factor activity, enhancer binding IEA Homeobox protein Meis1 12609849 15489334 15815621 17081983 19620614 9226379 NA MEIS1 -1 Homeobox protein Meis1 gene 8249 4.01696623728864E-4 ZNF423 C - Cellular Fate and Organization nucleus IDA positive regulation of BMP signaling pathway ISS Notch signaling pathway ISS positive regulation of transcription, DNA-dependent IDA negative regulation of transcription, DNA-dependent IDA transcription, DNA-dependent IEA cell differentiation IEA nervous system development IEA zinc ion binding IEA DNA binding IEA Zinc finger protein 423; Olf1/EBF-associated zinc finger protein; hOAZ; Smad- and Olf-interacting zinc finger protein 10660046 12168954 15489334 21406692 22863007 9872452 NA ZN423 -1 Zinc finger protein 423 Olf1/EBF-associated zinc finger protein hOAZ Smad- and Olf-interacting zinc finger protein gene 1291 4.69519573603869E-5 GNG11 C - Cellular Fate and Organization plasma membrane TAS heterotrimeric G-protein complex IEA signal transduction TAS energy reserve metabolic process TAS G-protein coupled receptor protein signaling pathway IEA GTPase activity TAS signal transducer activity IEA Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11; Precursor 12853948 15489334 7665596 NA GBG11 -1 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 Precursor gene 1291 0.00374688243165383 N - Not Matched mitochondrial membrane IEA membrane IDA motile secondary cilium ISS extracellular space TAS fructose biosynthetic process IDA L-xylitol catabolic process IDA glucose metabolic process TAS sorbitol catabolic process IDA sperm motility ISS NAD binding IDA L-iditol 2-dehydrogenase activity IDA carbohydrate binding NAS zinc ion binding IDA Sorbitol dehydrogenase; 1.1.1.14; L-iditol 2-dehydrogenase 12665801 12962626 14702039 15489334 16278369 16572171 19423711 20372835 21269460 2691249 7782086 8088829 9183016 NA DHSO 1 Sorbitol dehydrogenase 1.1.1.14 L-iditol 2-dehydrogenase gene 1291 0.136068548786856 Protein LSM12 homolog 14702039 15489334 19690332 21269460 NA LSM12 1 Protein LSM12 homolog gene 6425 0.0194442451726304 D - Genome Maintenance nuclear heterochromatin IEA cytoplasm IDA euchromatin IDA chromosome, pericentric region IEA nuclear matrix IDA methylation-dependent chromatin silencing IEA imprinting TAS S-adenosylhomocysteine metabolic process IEA negative regulation of transcription from RNA polymerase II promoter IEA spermatogenesis IEA DNA methylation during embryonic development IEA S-adenosylmethioninamine metabolic process IEA DNA methylation during gametogenesis IEA unmethylated CpG binding IEA DNA (cytosine-5-)-methyltransferase activity IDA chromatin binding IEA DNA binding IDA DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates IEA metal ion binding IEA DNA (cytosine-5)-methyltransferase 3A; Dnmt3a; 2.1.1.37; DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; M.HsaIIIA 10325416 10433969 12138111 12145218 15489334 15815621 16357870 16682412 17081983 17200670 17713477 18669648 19834512 20068231 20871592 21406692 21720545 21828135 22086334 NA DNM3A 1 DNA (cytosine-5)-methyltransferase 3A Dnmt3a 2.1.1.37 DNA methyltransferase HsaIIIA DNA MTase HsaIIIA M.HsaIIIA gene 1291 0.0244174348753505 D - Genome Maintenance endoplasmic reticulum IDA endoplasmic reticulum membrane IEA cell cycle IEA G2/M transition DNA damage checkpoint IMP protein transport IEA vesicle-mediated transport IEA RAD50-interacting protein 1; RAD50 interactor 1; HsRINT-1; RINT-1 11096100 12853948 14702039 15029241 15272311 15489334 16600870 21269460 NA RINT1 1 RAD50-interacting protein 1 RAD50 interactor 1 HsRINT-1 RINT-1 gene 1291 0.0235879342825634 A - Transport and Sensing basolateral plasma membrane IDA apical plasma membrane IEA Z disc ISS perinuclear region IEA integral to plasma membrane IEA postsynaptic membrane IEA costamere ISS T-tubule ISS cytoskeleton IEA M line ISS cytosol TAS axon guidance TAS positive regulation of calcium ion transport ISS calcium ion homeostasis ISS protein stabilization ISS positive regulation of potassium ion transport ISS potassium channel regulator activity IEA ATPase binding ISS protein binding, bridging ISS Ankyrin-2; ANK-2; Ankyrin-B; Brain ankyrin; Non-erythroid ankyrin 12571597 15178757 15262991 15489334 15611082 15815621 16959974 17974005 1830053 1833308 19007774 21269460 21406692 22411828 8253844 NA ANK2 -1 Ankyrin-2 ANK-2 Ankyrin-B Brain ankyrin Non-erythroid ankyrin gene 3969 1.12241996998781E-7 FOS C - Cellular Fate and Organization neuron projection IEA transcription factor complex IEA membrane IEA nucleoplasm TAS transcription from RNA polymerase II promoter TAS response to cold IEA response to cAMP IEA stress-activated MAPK cascade TAS regulation of transcription factor activity TAS inflammatory response TAS MyD88-dependent toll-like receptor signaling pathway TAS cellular response to extracellular stimulus IEA positive regulation of transcription from RNA polymerase II promoter IEA response to lipopolysaccharide IEA response to light stimulus IEA transforming growth factor beta receptor signaling pathway IDA conditioned taste aversion IEA response to corticosterone stimulus IEA pregnancy IEA regulation of transcription from RNA polymerase II promoter TAS response to drug IEA aging IEA response to toxin IEA sleep IEA response to mechanical stimulus IEA nervous system development IEA DNA methylation TAS Toll signaling pathway TAS response to gravity IEA innate immune response TAS positive regulation of transcription, DNA-dependent IDA sequence-specific DNA binding IEA transcription factor activity IDA double-stranded DNA binding IEA Proto-oncogene c-Fos; Cellular oncogene fos; G0/G1 switch regulatory protein 7 12134156 12508121 15489334 16055710 1658710 17203973 17709345 19690332 2511004 2516827 6574479 7588633 7816143 9732876 NA FOS -1 Proto-oncogene c-Fos Cellular oncogene fos G0/G1 switch regulatory protein 7 TF 1291 0.00126547566422802 PHF19 T - Transcription nucleus IEA regulation of transcription, DNA-dependent IEA transcription, DNA-dependent IEA zinc ion binding IEA PHD finger protein 19; Polycomb-like protein 3; hPCL3 15164053 15489334 15563832 17974005 18691976 21143197 22487681 23104054 23160351 23228662 23273982 NA PHF19 1 PHD finger protein 19 Polycomb-like protein 3 hPCL3 gene 1291 0.0599310847282657 AKAP2 N - Not Matched enzyme binding NAS A-kinase anchor protein 2; AKAP-2; AKAP-KL; Protein kinase A-anchoring protein 2; PRKA2 10231032 11478809 14702039 15164053 15489334 17081983 17974005 18220336 18669648 19690332 20068231 21406692 NA AKAP2 -1 A-kinase anchor protein 2 AKAP-2 AKAP-KL Protein kinase A-anchoring protein 2 PRKA2 gene 1291 0.0035102842708369 ALOX5AP R - Stress and Defence nuclear membrane IDA endoplasmic reticulum IDA endoplasmic reticulum membrane IEA integral to membrane IEA cytosol IEA leukotriene biosynthetic process IDA leukotriene production during acute inflammatory response IEA positive regulation of acute inflammatory response IEA glutathione biosynthetic process IBA positive regulation of enzyme activity IEA glutathione peroxidase activity IBA arachidonate 5-lipoxygenase activity IBA arachidonic acid binding IDA glutathione transferase activity IBA enzyme activator activity IEA Arachidonate 5-lipoxygenase-activating protein; FLAP; MK-886-binding protein 14770184 15057823 15489334 1673682 17304054 17600184 19233132 21269460 2300173 8245774 8440384 NA AL5AP -1 Arachidonate 5-lipoxygenase-activating protein FLAP MK-886-binding protein gene 2117 0.0136131056747202 MARVELD3 N - Not Matched tight junction IDA integral to membrane IEA intercellular junction assembly and maintenance IMP MARVEL domain-containing protein 3 14702039 15489334 15616553 20028514 NA MALD3 1 MARVEL domain-containing protein 3 gene 1291 0.0902558525606445 PHF11 T - Transcription nucleus IEA regulation of transcription, DNA-dependent IEA transcription, DNA-dependent IEA zinc ion binding IEA PHD finger protein 11; BRCA1 C-terminus-associated protein; Renal carcinoma antigen NY-REN-34 10508479 12754510 15057823 15489334 15674390 18405956 NA PHF11 -1 PHD finger protein 11 BRCA1 C-terminus-associated protein Renal carcinoma antigen NY-REN-34 gene 1662 0.207918265807285 novel 1 mir 1291 0.0747763912235243 F8 C - Cellular Fate and Organization plasma membrane TAS extracellular region NAS platelet alpha granule lumen TAS extracellular space IEA blood coagulation, intrinsic pathway TAS platelet degranulation TAS platelet activation TAS acute-phase response IEA cell adhesion IEA copper ion binding IEA oxidoreductase activity IEA Coagulation factor VIII; Antihemophilic factor; AHF; Procoagulant component; Factor VIIIa heavy chain, 200 kDa isoform; Factor VIIIa heavy chain, 92 kDa isoform; Factor VIII B chain; Factor VIIIa light chain; Precursor 10215414 10338101 10368977 10404764 10408784 10554831 10612839 10691849 10800171 10886198 10896236 10910910 10910913 11298607 11341489 11410838 11442643 11442647 11554935 11748850 11857744 11858487 12195713 12199686 12203998 12325022 12351418 12406074 12614369 12871415 12930394 1301194 1301932 1301960 1303178 1349567 1356412 1427887 14702039 15489334 1554716 15682412 15772651 15810915 16335952 1639429 16805874 18184865 1851341 1898735 1902642 1908096 1908817 1924291 1973901 2104766 2105106 2105906 2106480 2107542 21371196 2491949 2495245 2498882 2499363 2506948 2510835 2833855 2835904 3012775 3122181 3935400 6438526 6438528 7579394 7613471 7728145 7759074 7794769 7893714 8322269 8449505 8639447 8644728 8759905 9029040 9218428 9326186 9341862 9450898 9452104 9569180 9569189 9603440 9792405 9829908 9886318 NA FA8 -1 Coagulation factor VIII Antihemophilic factor AHF Procoagulant component Factor VIIIa heavy chain, 200 kDa isoform Factor VIIIa heavy chain, 92 kDa isoform Factor VIII B chain Factor VIIIa light chain Precursor gene 1291 0.0285443010498714 T - Transcription integral to endoplasmic reticulum membrane IDA dendrite ISS ER overload response TAS positive regulation of calcium ion transport IDA kidney development IMP sensory perception of sound IMP endoplasmic reticulum calcium ion homeostasis IDA protein stabilization ISS glucose homeostasis IMP ER-associated protein catabolic process ISS negative regulation of transcription factor activity ISS positive regulation of proteolysis ISS protein maturation via protein folding IC negative regulation of neuron apoptosis IMP positive regulation of protein ubiquitination ISS unfolded protein response, activation of signaling protein activity TAS visual perception IMP positive regulation of growth ISS transporter activity ISS ubiquitin protein ligase binding ISS Wolframin 10521293 10624825 10679252 10760554 11161832 11295831 11317350 11709537 11709538 12181639 14702039 15489334 15605410 15815621 16648378 16989814 18688868 20069065 21269460 21538838 22226368 9771706 9817917 NA WFS1 -1 Wolframin gene 1291 0.110735761722654 ADIPOR2 A - Transport and Sensing integral to membrane IEA fatty acid oxidation ISS hormone-mediated signaling ISS hormone binding ISS receptor activity IEA Adiponectin receptor protein 2; Progestin and adipoQ receptor family member II 12802337 14702039 15489334 16044242 NA ADR2 -1 Adiponectin receptor protein 2 Progestin and adipoQ receptor family member II gene 1291 0.00955317868538724 C - Cellular Fate and Organization transcription factor complex IEA negative regulation of cytokinesis ISS cell proliferation IEA positive regulation of transcription from RNA polymerase II promoter IMP sprouting angiogenesis IMP negative regulation of transcription from RNA polymerase II promoter ISS transcription, DNA-dependent IEA transcription factor activity IMP transcription corepressor activity ISS Transcription factor E2F8; E2F-8 14702039 15489334 15897886 16179649 18194653 18202719 18220336 22802528 22903062 NA E2F8 1 Transcription factor E2F8 E2F-8 gene 3257 1.0 C - Cellular Fate and Organization transcription factor complex IEA negative regulation of cytokinesis ISS negative regulation of cell proliferation IMP DNA damage response, signal transduction by p53 class mediator IDA positive regulation of transcription from RNA polymerase II promoter IMP sprouting angiogenesis IMP transcription, DNA-dependent IEA transcription factor activity IDA transcription corepressor activity ISS Transcription factor E2F7; E2F-7 14633988 14702039 15133492 15489334 16541075 18194653 18202719 18669648 19223542 20068231 21248772 22802528 22802529 22903062 NA E2F7 0 Transcription factor E2F7 E2F-7 TF 1291 0.0151106267335785 D - Genome Maintenance transcription factor complex IEA cytoplasm IEA nucleoplasm TAS transcription initiation from RNA polymerase II promoter TAS positive regulation of transcription from RNA polymerase II promoter TAS organ morphogenesis IEA transforming growth factor beta receptor signaling pathway TAS G1 phase of mitotic cell cycle TAS transcription factor activity NAS DNA binding IEA Transcription factor E2F5; E2F-5 16360038 16421571 17531812 7760804 7892279 8589754 9464260 NA E2F5 1 Transcription factor E2F5 E2F-5 gene 22824 1.0 D - Genome Maintenance transcription factor complex IEA nucleoplasm TAS regulation of cell size IEA transcription initiation from RNA polymerase II promoter TAS circulation IEA regulation of cell volume IEA cilium biogenesis IEA G1/S-specific transcription in mitotic cell cycle IEA regulation of cell proliferation IEA positive regulation of transcription from RNA polymerase II promoter TAS epithelial cell development IEA organ morphogenesis IEA transforming growth factor beta receptor signaling pathway TAS G1 phase of mitotic cell cycle TAS transcription factor activity IDA DNA binding IMP Transcription factor E2F4; E2F-4 10090723 10679953 10797289 11418595 14532282 15489334 15616553 16360038 17531812 17671431 19054851 7892279 7958924 7958925 9074408 NA E2F4 0 Transcription factor E2F4 E2F-4 TF 1291 0.00865292886199414 E2F3 D - Genome Maintenance transcription factor complex IEA nucleoplasm TAS G2 phase of mitotic cell cycle TAS positive regulation of cell proliferation IEA transcription initiation from RNA polymerase II promoter TAS G1 phase of mitotic cell cycle TAS positive regulation of transcription, DNA-dependent IEA transcription factor activity TAS Transcription factor E2F3; E2F-3 14574404 15716352 17974005 7584044 8246996 NA E2F3 1 Transcription factor E2F3 E2F-3 gene 28156 1.0 E2F1 D - Genome Maintenance cytoplasm IEA Rb-E2F complex IDA G2 phase of mitotic cell cycle TAS cell proliferation TAS positive regulation of transcription from RNA polymerase II promoter IMP apoptosis IMP DNA damage checkpoint IMP spermatogenesis IEA forebrain development IEA positive regulation of fibroblast proliferation IMP mRNA stabilization IDA G1 phase of mitotic cell cycle TAS transcription, DNA-dependent IEA sequence-specific DNA binding IEA transcription factor activity IDA transcription corepressor activity TAS Transcription factor E2F1; E2F-1; PBR3; Retinoblastoma-associated protein 1; RBAP-1; Retinoblastoma-binding protein 3; RBBP-3; pRB-binding protein E2F-1 10675335 11418595 11780052 12501191 12598654 12697828 12717439 1448092 15489334 15716352 16360038 1638634 1638635 17081983 17704056 18669648 19690332 21653699 7494286 7838523 7958836 7958856 7969176 8033208 8170954 8413249 8964493 9199321 9780002 NA E2F1 0 Transcription factor E2F1 E2F-1 PBR3 Retinoblastoma-associated protein 1 RBAP-1 Retinoblastoma-binding protein 3 RBBP-3 pRB-binding protein E2F-1 TF 1291 0.0349947638172555 A - Transport and Sensing protein complex IEA basolateral plasma membrane IEA cytoplasm IDA integral to plasma membrane TAS intercellular junction IEA T-tubule IEA external side of plasma membrane IDA response to radiation IEA excretion TAS pregnancy IEA body fluid osmoregulation IEP sensory perception of sound IEA hyperosmotic salinity response IEA protein homooligomerization IEA response to glucocorticoid stimulus IEA carbon dioxide transport IEA nervous system development TAS water channel activity EXP porin activity IEA Aquaporin-4; AQP-4; Mercurial-insensitive water channel; MIWC; WCH4 15489334 16177791 19383790 22328087 7559426 8601457 8855281 NA AQP4 -1 Aquaporin-4 AQP-4 Mercurial-insensitive water channel MIWC WCH4 gene 1291 0.0385082947407456 GIMAP8 M - Other Metabolism mitochondrion IEA cytoplasm IDA Golgi apparatus IEA endoplasmic reticulum IEA nucleus IDA GTP binding IEA GTPase IMAP family member 8; Immune-associated nucleotide-binding protein 9; IAN-9; Protein IanT 15489334 16103028 17974005 NA GIMA8 -1 GTPase IMAP family member 8 Immune-associated nucleotide-binding protein 9 IAN-9 Protein IanT gene 1291 0.0262453699169434 AQP1 F - Protein Fate sarcolemma IDA parasitophorous vacuole ISS cytoplasm IDA apical plasma membrane IDA nuclear membrane IDA basal plasma membrane IDA integral to plasma membrane TAS brush border membrane IDA negative regulation of apoptosis IDA establishment and/or maintenance of actin cytoskeleton polarity IMP ammonium transport IDA response to drug IDA positive regulation of fibroblast proliferation IDA pancreatic juice secretion IEP positive regulation of angiogenesis IMP regulation of cell volume IMP positive regulation of saliva secretion IMP lateral ventricle development IEP cGMP biosynthetic process IDA odontogenesis IEP bicarbonate transport TAS negative regulation of caspase activity IMP intracellular cGMP activated cation channel activity IDA glycerol transporter activity IDA nitric oxide transporter activity IDA water channel activity IDA ammonia transporter activity IDA potassium channel activity IMP Aquaporin-1; AQP-1; Aquaporin-CHIP; Urine water channel; Water channel protein for red blood cells and kidney proximal tubule 11034202 11171962 11532455 12853948 1373524 14702039 15489334 1722319 19054851 2007592 7507481 7517253 7518771 7521540 7521882 7677994 8340403 8703970 9177353 NA AQP1 -1 Aquaporin-1 AQP-1 Aquaporin-CHIP Urine water channel Water channel protein for red blood cells and kidney proximal tubule gene 1291 0.0816080920104172 GIMAP6 M - Other Metabolism GTP binding IEA GTPase IMAP family member 6; Immunity-associated nucleotide 2 protein; IAN-2; hIAN2; Immunity-associated nucleotide 6 protein; IAN-6; hIAN6 11964296 12097339 12853948 14702039 15474311 15489334 17974005 NA GIMA6 -1 GTPase IMAP family member 6 Immunity-associated nucleotide 2 protein IAN-2 hIAN2 Immunity-associated nucleotide 6 protein IAN-6 hIAN6 gene 1291 0.00137163971806715 MCM7 D - Genome Maintenance MCM complex IDA nucleoplasm TAS chromatin TAS cytosol IEA S phase of mitotic cell cycle TAS regulation of phosphorylation IMP G1/S transition of mitotic cell cycle TAS DNA strand elongation during DNA replication TAS DNA replication initiation IEA cell proliferation IEA response to drug IEA DNA unwinding during replication IEA cell cycle checkpoint TAS M/G1 transition of mitotic cell cycle TAS response to DNA damage stimulus IMP single-stranded DNA binding IEA ATP binding IEA DNA helicase activity IEA DNA replication licensing factor MCM7; 3.6.4.12; CDC47 homolog; P1.1-MCM3 12690205 12853948 14702039 15210935 15489334 15538388 16899510 17116885 17296731 18669648 18691976 19690332 20068231 21269460 22967762 7842741 8265339 8626784 9305914 NA MCM7 1 DNA replication licensing factor MCM7 3.6.4.12 CDC47 homolog P1.1-MCM3 gene 1291 0.101177391952852 D - Genome Maintenance MCM complex IDA nucleoplasm TAS S phase of mitotic cell cycle TAS G1/S transition of mitotic cell cycle TAS DNA strand elongation during DNA replication TAS DNA replication initiation IEA DNA unwinding during replication IEA cell cycle checkpoint TAS M/G1 transition of mitotic cell cycle TAS single-stranded DNA binding IEA ATP binding NAS DNA helicase activity IEA DNA replication licensing factor MCM6; 3.6.4.12; p105MCM 11095689 11788828 14702039 15489334 16899510 16964243 17116885 17159977 17296731 17525332 18669648 19690332 20068231 20202939 21269460 22967762 8977093 9286856 9305914 9516426 NA MCM6 1 DNA replication licensing factor MCM6 3.6.4.12 p105MCM gene 3109 0.00317765522633011 SPTBN1 D - Genome Maintenance spectrin TAS nucleolus IDA cuticular plate IEA axolemma ISS M line IEA cytosol TAS common-partner SMAD protein phosphorylation IEA cytokinesis after mitosis IMP axon guidance TAS Golgi to plasma membrane protein transport IMP SMAD protein nuclear translocation IEA actin filament capping IEA phospholipid binding IEA structural constituent of cytoskeleton IMP ankyrin binding NAS actin binding TAS Spectrin beta chain, non-erythrocytic 1; Beta-II spectrin; Fodrin beta chain; Spectrin, non-erythroid beta chain 1 10806113 11665863 15262991 1527002 15489334 15815621 17081983 17924679 18088087 18669648 18691976 19369195 19608861 19690332 20068231 21269460 21406692 8406479 9164454 9817844 NA SPTB2 -1 Spectrin beta chain, non-erythrocytic 1 Beta-II spectrin Fodrin beta chain Spectrin, non-erythroid beta chain 1 gene 1291 0.0483359921870727 MCM4 D - Genome Maintenance MCM complex IDA nucleoplasm TAS S phase of mitotic cell cycle TAS G1/S transition of mitotic cell cycle TAS DNA strand elongation during DNA replication TAS DNA replication initiation IEA DNA unwinding during replication IEA cell cycle checkpoint TAS M/G1 transition of mitotic cell cycle TAS single-stranded DNA binding IEA ATP binding NAS DNA helicase activity IEA DNA replication licensing factor MCM4; 3.6.4.12; CDC21 homolog; P1-CDC21 15489334 16899510 17081983 17296731 18669648 18691976 19608861 19690332 20068231 21269460 21406692 7601140 8265339 9284934 9305914 9465298 NA MCM4 1 DNA replication licensing factor MCM4 3.6.4.12 CDC21 homolog P1-CDC21 gene 1291 0.0781675657111357 CHRDL1 C - Cellular Fate and Organization extracellular region TAS compound eye development (sensu Endopterygota) IMP ossification IEA BMP signaling pathway TAS cell differentiation IEA nervous system development IEA Chordin-like protein 1; Neuralin-1; Neurogenesin-1; Ventroptin; Precursor 14702039 15489334 15772651 18587495 22284829 NA CRDL1 -1 Chordin-like protein 1 Neuralin-1 Neurogenesin-1 Ventroptin Precursor gene 1291 0.0849340188103281 SLC5A6 A - Transport and Sensing vesicle membrane IEA integral to plasma membrane TAS brush border membrane IEA pantothenate transport IEA pantothenate metabolic process TAS biotin metabolic process TAS biotin transport IEA sodium-dependent multivitamin transporter activity TAS Sodium-dependent multivitamin transporter; Na(+)-dependent multivitamin transporter; Solute carrier family 5 member 6 10329687 10334869 14702039 15489334 15815621 NA SC5A6 1 Sodium-dependent multivitamin transporter Na(+)-dependent multivitamin transporter Solute carrier family 5 member 6 gene 1291 0.0413570303508753 N - Not Matched integral to plasma membrane TAS myo-inositol metabolic process IEA regulation of respiratory gaseous exchange IEA peripheral nervous system development IEA myo-inositol:sodium symporter activity TAS Sodium/myo-inositol cotransporter; Na(+)/myo-inositol cotransporter; Sodium/myo-inositol transporter 1; SMIT1; Solute carrier family 5 member 3 10830953 7789985 9441750 NA SC5A3 1 Sodium/myo-inositol cotransporter Na(+)/myo-inositol cotransporter Sodium/myo-inositol transporter 1 SMIT1 Solute carrier family 5 member 3 gene 1291 0.00323169906125048 D - Genome Maintenance condensed chromosome kinetochore IEA kinetochore IDA nucleus IEA dendrite IEA cytosol TAS mitotic prometaphase TAS mitotic sister chromatid segregation IDA mitotic checkpoint IDA phosphoinositide-mediated signaling NAS establishment of cellular localization IDA spindle organization and biogenesis NAS cell division IEA ZW10 interactor; ZW10-interacting protein 1; Zwint-1 10806105 15094189 15485811 15489334 15502821 15824131 16732327 21269460 NA ZWINT 1 ZW10 interactor ZW10-interacting protein 1 Zwint-1 gene 3057 0.00602036665382763 MYCBP D - Genome Maintenance mitochondrion IEA cytoplasm IDA centrosome IDA nucleus IDA regulation of transcription, DNA-dependent IDA spermatogenesis IEP transcription, DNA-dependent IEA transcription coactivator activity IDA C-Myc-binding protein; Associate of Myc 1; AMY-1 11483602 12151104 12665801 14702039 15489334 16710414 19054851 21269460 9797456 NA MYCBP -1 C-Myc-binding protein Associate of Myc 1 AMY-1 gene 1291 0.0947091236009375 ORC5 D - Genome Maintenance cytoplasm IDA nucleoplasm TAS nuclear origin of replication recognition complex IDA S phase of mitotic cell cycle TAS G1/S transition of mitotic cell cycle TAS DNA replication initiation TAS cell cycle checkpoint TAS M/G1 transition of mitotic cell cycle TAS nucleotide binding TAS DNA replication origin binding TAS ATP binding IEA Origin recognition complex subunit 5 12690205 12853948 12909626 15489334 17716973 21269460 9417919 9765232 9829972 NA ORC5 1 Origin recognition complex subunit 5 gene 1291 0.100977645694874 CALHM2 N - Not Matched integral to membrane IEA Calcium homeostasis modulator protein 2; Protein FAM26B 14702039 15164054 15489334 18585350 NA CAHM2 -1 Calcium homeostasis modulator protein 2 Protein FAM26B gene 70877 0.0390028437147506 novel 1 mir 50312 0.0423963122458846 novel 1 mir 1291 0.0151106267335785 MRPL42 P - Translation plasma membrane IDA mitochondrial small ribosomal subunit IDA translation NAS structural constituent of ribosome NAS 39S ribosomal protein L42, mitochondrial; L42mt; MRP-L42; 28S ribosomal protein S32, mitochondrial; MRP-S32; S32mt; 39S ribosomal protein L31, mitochondrial; L31mt; MRP-L31; Precursor 11042152 11230166 11279123 11543634 11551941 14702039 15489334 21269460 NA RM42 1 39S ribosomal protein L42, mitochondrial L42mt MRP-L42 28S ribosomal protein S32, mitochondrial MRP-S32 S32mt 39S ribosomal protein L31, mitochondrial L31mt MRP-L31 Precursor gene 3700 0.627945026924428 novel -1 mir 1291 9.22127029133089E-4 TMEM186 N - Not Matched mitochondrion IDA integral to membrane IEA Transmembrane protein 186 11230166 14702039 15489334 NA TM186 1 Transmembrane protein 186 gene 1647 0.0994998451839461 ZFP36 C - Cellular Fate and Organization nucleus IDA cytosol IDA RNA destabilization IEA regulation of tumor necrosis factor-alpha production IDA negative regulation of myeloid cell differentiation IEA negative regulation of inflammatory response IEA response to stress IDA negative regulation of transcription from RNA polymerase II promoter IMP mRNA catabolic process IDA poly(A) tail shortening IEA protein kinase cascade IEA single-stranded RNA binding TAS AU-specific RNA binding IDA zinc ion binding IEA mRNA binding IDA DNA binding IEA Tristetraprolin; TTP; G0/G1 switch regulatory protein 24; Growth factor-inducible nuclear protein NUP475; Protein TIS11A; TIS11; Zinc finger protein 36 homolog; Zfp-36 14702039 15014438 15489334 16262601 18669648 19369195 2062660 21406692 NA TTP -1 Tristetraprolin TTP G0/G1 switch regulatory protein 24 Growth factor-inducible nuclear protein NUP475 Protein TIS11A TIS11 Zinc finger protein 36 homolog Zfp-36 gene 1291 0.00896578061676545 MPDZ C - Cellular Fate and Organization Schmidt-Lanterman cleft IEA cytoplasm IDA apical plasma membrane IEA postsynaptic membrane IEA postsynaptic density IEA tight junction IEA cytoplasmic vesicle IEA apicolateral plasma membrane IDA virus-host interaction IEA myelination IEA cell adhesion IEA Multiple PDZ domain protein; Multi-PDZ domain protein 1 11000240 11150294 11802782 14702039 15164053 15312654 15316081 15364909 15489334 17384233 17974005 18669648 21406692 9537516 NA MPDZ -1 Multiple PDZ domain protein Multi-PDZ domain protein 1 gene 1291 6.86433599827297E-4 SVEP1 C - Cellular Fate and Organization cytoplasm IEA membrane IEA extracellular region IEA cell adhesion IEA chromatin binding IEA calcium ion binding IEA Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1; CCP module-containing protein 22; Polydom; Selectin-like osteoblast-derived protein; SEL-OB; Serologically defined breast cancer antigen NY-BR-38; Precursor 11062057 12747765 14702039 15164053 15489334 16206243 17974005 22171320 NA SVEP1 -1 Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 CCP module-containing protein 22 Polydom Selectin-like osteoblast-derived protein SEL-OB Serologically defined breast cancer antigen NY-BR-38 Precursor gene 1291 0.00375315258666234 ADH1B N - Not Matched cytosol TAS xenobiotic metabolic process TAS ethanol oxidation IDA nucleotide binding IEA alcohol dehydrogenase activity, zinc-dependent IDA zinc ion binding IDA Alcohol dehydrogenase 1B; 1.1.1.1; Alcohol dehydrogenase subunit beta 10733556 11274460 15489334 1896463 2547609 2679216 2935533 2935875 2986130 3000832 3397059 3619918 6374651 6391920 8201622 8663387 NA ADH1B -1 Alcohol dehydrogenase 1B 1.1.1.1 Alcohol dehydrogenase subunit beta gene 1291 0.307481760683889 MCL1 C - Cellular Fate and Organization mitochondrial matrix IEA nucleus IDA nucleoplasm IEA mitochondrial outer membrane TAS integral to membrane IEA cell homeostasis NAS cell fate determination NAS apoptosis IDA multicellular organismal development IEA protein channel activity TAS Induced myeloid leukemia cell differentiation protein Mcl-1; Bcl-2-like protein 3; Bcl2-L-3; Bcl-2-related protein EAT/mcl1; mcl1/EAT 10634649 10766760 10837489 11130466 12149273 12223490 14702039 15077116 15122313 15241487 15489334 15989957 16710414 17389404 18669648 18987736 20562877 23024798 23055042 7682708 8790944 9671497 NA MCL1 -1 Induced myeloid leukemia cell differentiation protein Mcl-1 Bcl-2-like protein 3 Bcl2-L-3 Bcl-2-related protein EAT/mcl1 mcl1/EAT gene 1291 0.101177391952852 A - Transport and Sensing Golgi cis face IEA Golgi membrane TAS endoplasmic reticulum membrane IEA Golgi cisterna IEA integral to membrane IEA ER to Golgi vesicle-mediated transport TAS vesicle fusion with Golgi apparatus IEA protein transport IEA BET1 homolog; hBET1; Golgi vesicular membrane-trafficking protein p18 12853948 15489334 17081983 18669648 20068231 21269460 21406692 9382863 NA BET1 1 BET1 homolog hBET1 Golgi vesicular membrane-trafficking protein p18 gene 1291 0.00401808768260578 SFN C - Cellular Fate and Organization cytoplasm IDA nucleus IEA extracellular space TAS positive regulation of protein export from nucleus IEA negative regulation of cell proliferation IEA DNA damage response, signal transduction resulting in induction of apoptosis IDA keratinocyte differentiation IEA positive regulation of cell growth IEA release of cytochrome c from mitochondria IDA skin development IEA regulation of cyclin-dependent protein kinase activity IEA negative regulation of caspase activity IDA keratinocyte proliferation IEA protein kinase C inhibitor activity TAS 14-3-3 protein sigma; Epithelial cell marker protein 1; Stratifin 1286667 1390337 15282546 15489334 15731107 16710414 16964243 18669648 18691976 19172738 19592491 20068231 21269460 21625211 8515476 9659898 NA 1433S 1 14-3-3 protein sigma Epithelial cell marker protein 1 Stratifin gene 1291 0.015193707803644 FERMT2 C - Cellular Fate and Organization stress fiber NAS filamentous actin IEA nucleus IDA focal adhesion IDA cell cortex IEA cytosol TAS actin cytoskeleton organization and biogenesis NAS regulation of cell shape IEA cell adhesion NAS phospholipid binding IEA Fermitin family homolog 2; Kindlin-2; Mitogen-inducible gene 2 protein; MIG-2; Pleckstrin homology domain-containing family C member 1; PH domain-containing family C member 1 12508121 12679033 12697302 15489334 18669648 18691976 19690332 20068231 21269460 21406692 8175911 NA FERM2 -1 Fermitin family homolog 2 Kindlin-2 Mitogen-inducible gene 2 protein MIG-2 Pleckstrin homology domain-containing family C member 1 PH domain-containing family C member 1 gene 1291 0.158667429513406 PRELP C - Cellular Fate and Organization Golgi lumen TAS extracellular matrix (sensu Metazoa) TAS lysosomal lumen TAS skeletal development TAS keratan sulfate biosynthetic process TAS carbohydrate metabolic process TAS cell aging IEA keratan sulfate catabolic process TAS heparin binding IEA extracellular matrix structural constituent TAS Prolargin; Proline-arginine-rich end leucine-rich repeat protein; Precursor 15489334 16710414 19159218 7592739 8954791 NA PRELP -1 Prolargin Proline-arginine-rich end leucine-rich repeat protein Precursor gene 1291 0.219825059936691 M - Other Metabolism extracellular space IDA iron ion homeostasis TAS copper ion transport IEA ferroxidase activity TAS copper ion binding IEA Ceruloplasmin; 1.16.3.1; Ferroxidase; Precursor 12055353 14760718 15084671 15557511 16150804 16335952 17242517 19159218 19838169 2355023 2873574 3486416 3755405 6571985 6582496 6940148 6987229 6987230 7702601 NA CERU 1 Ceruloplasmin 1.16.3.1 Ferroxidase Precursor gene 1291 0.401766357395265 PTGIS T - Transcription caveola IDA endoplasmic reticulum membrane TAS nucleus IDA integral to membrane IEA extracellular space ISS xenobiotic metabolic process TAS positive regulation of apoptosis IDA prostaglandin biosynthetic process IDA negative regulation of nitric oxide biosynthetic process IDA negative regulation of inflammatory response IDA inhibition of NF-kappaB transcription factor IDA positive regulation of angiogenesis IMP monooxygenase activity IEA iron ion binding IEA prostaglandin-I synthase activity IDA electron carrier activity IEA oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA heme binding NAS Prostacyclin synthase; 5.3.99.4; Prostaglandin I2 synthase 11281454 11780052 15489334 8185632 NA PTGIS -1 Prostacyclin synthase 5.3.99.4 Prostaglandin I2 synthase gene 1291 0.229882269744199 PTGIR C - Cellular Fate and Organization integral to plasma membrane TAS cytosol IDA blood coagulation TAS positive regulation of cAMP biosynthetic process IMP cell-cell signaling TAS response to lipopolysaccharide IEA negative regulation of smooth muscle cell proliferation IDA G-protein signaling, adenylate cyclase activating pathway IMP guanyl-nucleotide exchange factor activity TAS G-protein coupled receptor activity IEA Prostacyclin receptor; Prostaglandin I2 receptor; PGI receptor; PGI2 receptor; Prostanoid IP receptor; Precursor 11895442 12488443 15194446 15489334 7512962 7514139 7665161 7923647 NA PI2R -1 Prostacyclin receptor Prostaglandin I2 receptor PGI receptor PGI2 receptor Prostanoid IP receptor Precursor gene 2149 0.0379207494027276 FLT1 C - Cellular Fate and Organization Golgi apparatus IDA integral to plasma membrane IDA nucleus IDA extracellular space TAS endosome IEA positive regulation of vascular endothelial growth factor receptor signaling pathway IDA patterning of blood vessels IEA positive regulation of cell proliferation TAS positive regulation of cell migration IDA blood vessel morphogenesis ISS sprouting angiogenesis IEA positive regulation of phosphoinositide 3-kinase cascade IMP peptidyl-tyrosine phosphorylation IDA embryonic morphogenesis ISS cell differentiation IEA positive regulation of angiogenesis IMP monocyte chemotaxis IDA protein amino acid autophosphorylation IDA positive regulation of phosphoinositide 3-kinase activity IMP positive regulation of MAPK activity IDA ATP binding IEA Vascular endothelial growth factor receptor 1; VEGFR-1; 2.7.10.1; Fms-like tyrosine kinase 1; FLT-1; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; FLT; Vascular permeability factor receptor; Precursor 10471394 10543948 11141500 11312102 11513746 11811792 12796773 14633857 14684734 14702039 15001553 15057823 15489334 15735759 16286478 16685275 17002866 17344846 18079407 18515749 18583712 18593464 18680722 19230644 19761875 20127948 20501651 20512933 20551949 21212275 21558755 2158038 21711246 21752276 22016384 3040650 7824266 8248162 8605350 9299537 9393862 9600074 9722576 NA VGFR1 -1 Vascular endothelial growth factor receptor 1 VEGFR-1 2.7.10.1 Fms-like tyrosine kinase 1 FLT-1 Tyrosine-protein kinase FRT Tyrosine-protein kinase receptor FLT FLT Vascular permeability factor receptor Precursor gene 9888 0.00406779176081695 C - Cellular Fate and Organization nucleus IEA cerebral cortex development IEA sebaceous gland development IEA regulation of epidermis development IEA cell-cell signaling TAS forebrain neuron fate commitment IEA skin development IEA trophectodermal cell differentiation IEA somatic stem cell maintenance IEA germ-line stem cell maintenance IEA hair follicle development IEA male gonad development IEP protein dimerization activity IDA DNA binding IDA Transcription factor AP-2 gamma; AP2-gamma; Activating enhancer-binding protein 2 gamma; Transcription factor ERF-1 11694877 11744733 11780052 12072434 12586840 15489334 15548692 18669648 19115315 21406692 8661133 9113991 NA AP2C 1 Transcription factor AP-2 gamma AP2-gamma Activating enhancer-binding protein 2 gamma Transcription factor ERF-1 TF 8501 1.0 TFAP2A D - Genome Maintenance centrosome IDA Golgi apparatus IDA nucleus IDA negative regulation of cell proliferation IDA sensory perception of sound IMP trigeminal nerve development ISS embryonic cranial skeleton morphogenesis ISS epidermis morphogenesis IEA embryonic pattern specification IEA positive regulation of neuron apoptosis IDA neural crest cell development IEA palate development IMP oculomotor nerve formation ISS embryonic body morphogenesis IEA negative regulation of apoptosis IDA positive regulation of bone mineralization IDA positive regulation of cell migration IEA inner ear morphogenesis IMP kidney development IMP negative regulation of epidermal growth factor receptor signaling pathway IEA sympathetic nervous system development IEA anterior neuropore closure IEA regulation of neuron differentiation IEA regulation of cell differentiation IDA skin development IEA embryonic forelimb morphogenesis ISS forebrain neuron development IEA sequence-specific DNA binding IDA chromatin binding ISS transcription coactivator activity IDA protein homodimerization activity TAS Transcription factor AP-2-alpha; AP2-alpha; AP-2 transcription factor; Activating enhancer-binding protein 2-alpha; Activator protein 2; AP-2 10037142 11694877 11744733 12072434 12586840 12775724 14574404 15489334 15548692 18423521 18669648 19115315 1998122 2010091 3063603 8190633 8321221 NA AP2A 0 Transcription factor AP-2-alpha AP2-alpha AP-2 transcription factor Activating enhancer-binding protein 2-alpha Activator protein 2 AP-2 TF 1291 0.192219042941373 R - Stress and Defence membrane attack complex TAS extracellular region TAS complement activation, alternative pathway IEA complement activation TAS innate immune response TAS complement activation, classical pathway IEA cytolysis IEA Complement component C7; Precursor 10551839 14760718 15489334 16335952 19419965 22028381 22171320 3335508 7730625 8871666 9218625 9856499 NA CO7 -1 Complement component C7 Precursor gene 1299 0.0206031870155919 CFB F - Protein Fate plasma membrane TAS extracellular region TAS complement activation, alternative pathway NAS regulation of complement activation TAS proteolysis IEA complement binding TAS serine-type endopeptidase activity TAS Complement factor B; 3.4.21.47; C3/C5 convertase; Glycine-rich beta glycoprotein; GBG; PBF2; Properdin factor B; Complement factor B Ba fragment; Complement factor B Bb fragment; Precursor 10637221 14574404 14656967 15489334 16335952 16518403 17182750 19159218 19574954 2006911 20513133 2249879 3643061 6308626 6323161 6342610 6546754 6957884 8181962 8225386 8247029 NA CFAB 1 Complement factor B 3.4.21.47 C3/C5 convertase Glycine-rich beta glycoprotein GBG PBF2 Properdin factor B Complement factor B Ba fragment Complement factor B Bb fragment Precursor gene 1291 0.0347288524571649 F - Protein Fate extracellular space TAS regulation of complement activation TAS innate immune response TAS complement activation, classical pathway TAS proteolysis IEA serine-type endopeptidase activity IEA Complement C2; 3.4.21.43; C3/C5 convertase; Complement C2b fragment; Complement C2a fragment; Precursor 10734221 14574404 14702039 15489334 16335952 16518403 19159218 19237749 2493504 2949737 2997031 3643061 6149575 6199794 6555044 6922702 8326124 8621452 9670930 NA CO2 1 Complement C2 3.4.21.43 C3/C5 convertase Complement C2b fragment Complement C2a fragment Precursor gene 1291 0.0125304158240803 NA -1 gene 1291 0.257028418487351 GPX3 T - Transcription extracellular space IDA response to lipid hydroperoxide TAS protein homotetramerization IDA hydrogen peroxide catabolic process TAS glutathione peroxidase activity IDA selenium binding IDA transcription factor binding TAS Glutathione peroxidase 3; GPx-3; GSHPx-3; 1.11.1.9; Extracellular glutathione peroxidase; Plasma glutathione peroxidase; GPx-P; GSHPx-P; Precursor 10970826 1339300 15489334 16641997 1897960 2229017 8056346 NA GPX3 -1 Glutathione peroxidase 3 GPx-3 GSHPx-3 1.11.1.9 Extracellular glutathione peroxidase Plasma glutathione peroxidase GPx-P GSHPx-P Precursor gene 1291 0.0550793834643225 P - Translation mitochondrion IEA ribosome IEA translation IEA structural constituent of ribosome IEA 39S ribosomal protein L24, mitochondrial; L24mt; MRP-L24; Precursor 11543634 14702039 15489334 16710414 21269460 NA RM24 1 39S ribosomal protein L24, mitochondrial L24mt MRP-L24 Precursor gene 1291 0.110735761722654 PSIP1 T - Transcription nuclear heterochromatin IDA nucleoplasm IDA cytosol TAS nuclear mRNA 5'-splice site recognition IDA regulation of transcription, DNA-dependent IEA response to heat ISS virus-host interaction IEA viral reproduction TAS response to oxidative stress ISS transcription, DNA-dependent IEA chromatin binding IDA PC4 and SFRS1-interacting protein; CLL-associated antigen KW-7; Dense fine speckles 70 kDa protein; DFS 70; Lens epithelium-derived growth factor; Transcriptional coactivator p75/p52 10623627 10721720 10856157 12200376 15164053 15475359 15489334 15642333 15725483 15749713 15797927 15895093 16260736 17081983 17525332 18318008 18669648 19244240 19367720 19690332 20068231 21269460 21406692 9822615 9885563 NA PSIP1 -1 PC4 and SFRS1-interacting protein CLL-associated antigen KW-7 Dense fine speckles 70 kDa protein DFS 70 Lens epithelium-derived growth factor Transcriptional coactivator p75/p52 gene 2327 9.7502512336004E-4 N - Not Matched cytoplasm IEA polysome IEA stem cell development IEA poly(U) binding IEA nucleotide binding IEA RNA-binding protein Musashi homolog 2; Musashi-2 12649177 14702039 15489334 18691976 20068231 21269460 NA MSI2H 1 RNA-binding protein Musashi homolog 2 Musashi-2 gene 1291 0.0170539940032999 LEPR A - Transport and Sensing plasma membrane IEA extracellular region IEA integral to membrane IEA energy reserve metabolic process TAS negative regulation of hydrolase activity IEA cytokine and chemokine mediated signaling pathway IEA multicellular organismal development TAS cholesterol metabolic process IEA hematopoietin/interferon-class (D200-domain) cytokine receptor activity IEA transmembrane receptor activity TAS Leptin receptor; LEP-R; HuB219; OB receptor; OB-R; CD295; Precursor 16335952 18987736 19159218 22405007 8548812 8616721 8666155 8805376 9061609 9144432 9158141 9175732 9287054 9600917 9786864 9860295 9929394 NA LEPR -1 Leptin receptor LEP-R HuB219 OB receptor OB-R CD295 Precursor gene 3851 1.0 AR C - Cellular Fate and Organization axon IEA protein complex IDA cytoplasm IDA nuclear chromatin IDA plasma membrane IEA nucleoplasm TAS dendrite IEA cell death IEA positive regulation of cell proliferation IDA transcription initiation from RNA polymerase II promoter TAS cell proliferation NAS cell-cell signaling TAS negative regulation of epithelial cell proliferation IEA protein oligomerization IDA organ formation IEA activation of NF-kappaB transcription factor IMP positive regulation of transcription from RNA polymerase II promoter IDA positive regulation of transcription from RNA polymerase III promoter IDA transport TAS male genitalia morphogenesis IEA sex differentiation NAS prostate gland development NAS negative regulation of integrin biosynthetic process IDA negative regulation of apoptosis IDA positive regulation of integrin biosynthetic process IDA embryonic development (sensu Mammalia) IEA male somatic sex determination IEA regulation of catalytic activity IEA positive regulation of insulin-like growth factor receptor signaling pathway IEA regulation of developmental growth IEA cell growth NAS positive regulation of MAPKKK cascade IEA male gonad development IEA positive regulation of phosphorylation IMP sequence-specific DNA binding IEA androgen receptor activity IDA beta-catenin binding IDA chromatin binding IDA protein dimerization activity NAS zinc ion binding IEA androgen binding NAS Androgen receptor; Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4 10022458 10075738 10092153 10221692 10221770 10332029 10363963 10383460 10400640 10404311 10458483 10470409 10502786 10543676 10569618 10571951 10590024 10598582 10625666 10629558 10690872 10706109 10840043 10930412 11121022 11231320 11587068 11744994 11906285 12039962 12361945 12415108 12612053 12958311 1303262 1307250 1316540 1424203 1426313 1430233 14573606 1458719 14609956 1464650 14664718 1480178 1487249 15489334 15525515 15563469 1561105 1562539 15634333 1569163 15772651 15851746 15902657 16027218 16051670 1609793 16129672 1631125 16595706 16641486 16951154 17045208 17311914 17494760 17550981 17587566 17591767 17711855 1775137 17911242 18007036 18084323 18222118 18451096 18451177 1856263 19345326 19909775 1999491 2010552 20501646 20623637 2062380 2082179 20980437 21406692 21512132 22031296 22334387 2260966 2293020 2342476 2546571 2594783 2911578 2917688 3174628 3216866 3353726 3353727 3377788 7511268 7537149 7581399 7591265 7626493 7633398 7641413 7649358 7671849 7673412 7712463 7723794 7909256 7910529 7929841 7937057 7962294 7970939 7981687 7981689 7993455 8033918 8040309 8096390 8097257 8103398 8126121 8145761 8162033 8187068 8205256 8213813 8224266 8240973 8274409 8281139 8281140 8292051 8325932 8325950 8339746 8413310 8446106 8530589 8550758 8626869 8628719 8647313 8683794 8723113 8768864 8809734 8823308 8824883 8827083 8830623 8918984 8990010 9000575 9001799 9007482 9016528 9039340 9096391 9106550 9160185 9184448 9196614 9252933 9255042 9302173 9328206 9329414 9438000 9543136 9544375 9554754 9554755 9607727 9610419 9627582 9698822 9768671 9788719 9816170 9851768 9856504 NA ANDR 0 Androgen receptor Dihydrotestosterone receptor Nuclear receptor subfamily 3 group C member 4 TF 2099 0.0562140580053808 D - Genome Maintenance nucleoplasm TAS cytosol TAS transcription from RNA polymerase II promoter IEA isoleucine metabolic process ISS sequestering of lipid IEA taurine metabolic process ISS cytokine and chemokine mediated signaling pathway IEA luteinization IEA positive regulation of natural killer cell proliferation IEA regulation of cell adhesion IEA Peyer's patch development IEA response to lipopolysaccharide IEA T cell homeostasis IEA response to estradiol stimulus IDA development of secondary female sexual characteristics IEA pregnancy IEA development of secondary male sexual characteristics IEA positive regulation of gamma-delta T cell differentiation IEA creatinine metabolic process ISS positive regulation of natural killer cell differentiation IEA acute-phase response IEA regulation of steroid metabolic process IEA liver development IEA positive regulation of interleukin-2 biosynthetic process IEA positive regulation of progression through mitotic cell cycle IEA negative regulation of erythrocyte differentiation IEA creatine metabolic process ISS progesterone metabolic process IEA allantoin metabolic process ISS response to ethanol IEA positive regulation of B cell differentiation IEA citrate metabolic process ISS positive regulation of activated T cell proliferation IEA regulation of epithelial cell differentiation IEA succinate metabolic process ISS positive regulation of transcription from RNA polymerase II promoter ISS 2-oxoglutarate metabolic process ISS regulation of body size ISS fatty acid metabolic process ISS natural killer cell differentiation IEA valine metabolic process ISS positive regulation of body size IEA response to hypoxia IEA negative regulation of apoptosis IEA oxaloacetate metabolic process ISS positive regulation of smooth muscle cell proliferation IEA lactation IEA positive regulation of natural killer cell mediated cytotoxicity IEA positive regulation of inflammatory response IEA positive regulation of cell motility IEA double-stranded DNA binding IEA transcription factor activity TAS calcium ion binding IEA signal transducer activity IEA Signal transducer and activator of transcription 5B 12039059 12411494 12954634 13679528 14504097 15121872 15489334 15526160 15677474 15827093 16964243 17997837 18669648 18691976 19690332 20068231 21135090 21269460 22419735 8631883 8732682 9428692 9989503 NA STA5B -1 Signal transducer and activator of transcription 5B TF 1291 0.0126543239549583 MRPL19 P - Translation mitochondrion IEA nuclear membrane IDA ribosome IEA translation IEA structural constituent of ribosome IEA 39S ribosomal protein L19, mitochondrial; L19mt; MRP-L19; 39S ribosomal protein L15, mitochondrial; L15mt; MRP-L15; Precursor 10600119 11543634 15489334 15815621 21269460 7788527 NA RM19 1 39S ribosomal protein L19, mitochondrial L19mt MRP-L19 39S ribosomal protein L15, mitochondrial L15mt MRP-L15 Precursor gene 1291 0.0783685434449873 MRPL17 P - Translation mitochondrial inner membrane IEA ribosome IEA translation IEA structural constituent of ribosome IEA 39S ribosomal protein L17, mitochondrial; L17mt; MRP-L17; LYST-interacting protein 2; Precursor 10931946 11543634 11984006 14702039 15489334 21269460 NA RM17 1 39S ribosomal protein L17, mitochondrial L17mt MRP-L17 LYST-interacting protein 2 Precursor gene 1291 0.0285443010498714 TBC1D2 C - Cellular Fate and Organization cell junction IDA cytoplasmic membrane-bound vesicle IEA nucleus IDA cytoplasmic vesicle IDA phospholipid binding IEA Rab GTPase activator activity IDA TBC1 domain family member 2A; Armus; Prostate antigen recognized and identified by SEREX 1; PARIS-1 11785977 14702039 15164053 15489334 17081983 17974005 18669648 19077034 20116244 21269460 NA TBD2A -1 TBC1 domain family member 2A Armus Prostate antigen recognized and identified by SEREX 1 PARIS-1 gene 1291 0.132427427935845 TMEM88 N - Not Matched integral to membrane IEA Transmembrane protein 88 15489334 NA TMM88 -1 Transmembrane protein 88 gene 1291 0.0649142228704888 KAL1 C - Cellular Fate and Organization plasma membrane IEA extracellular matrix (sensu Metazoa) TAS extracellular space TAS axon guidance TAS cell motility TAS cell adhesion TAS serine-type endopeptidase inhibitor activity IEA heparin binding IEA extracellular matrix structural constituent TAS Anosmin-1; Adhesion molecule-like X-linked; Kallmann syndrome protein; Precursor 11297579 12007408 1303284 15001591 15471890 15489334 15605412 15772651 17054399 17213338 17223984 1913827 1922361 19696444 20530987 21168128 7590336 8504298 8832397 8842728 8989261 9589672 NA KALM -1 Anosmin-1 Adhesion molecule-like X-linked Kallmann syndrome protein Precursor gene 1291 0.0651197801949104 CTHRC1 N - Not Matched collagen IEA cytoplasm IEA extracellular space IDA positive regulation of osteoblast differentiation IEA cell migration IEA positive regulation of protein binding IEA Collagen triple helix repeat-containing protein 1; Protein NMTC1; Precursor 12975309 15340161 15489334 15618538 21791690 NA CTHR1 1 Collagen triple helix repeat-containing protein 1 Protein NMTC1 Precursor gene 3344 0.00914305577801058 N - Not Matched late endosome membrane IEA integral to membrane IEA lysosomal membrane IEA Transmembrane protein 106B 12690205 12853948 14702039 15489334 17081983 19159218 20068231 20154673 22511793 NA T106B 1 Transmembrane protein 106B gene 1291 0.00375315258666234 PTPRZ1 C - Cellular Fate and Organization integral to plasma membrane TAS extracellular matrix (sensu Metazoa) IEA axonogenesis IEA central nervous system development TAS transmembrane receptor protein tyrosine phosphatase activity TAS protein tyrosine/threonine phosphatase activity NAS Receptor-type tyrosine-protein phosphatase zeta; R-PTP-zeta; 3.1.3.48; Protein-tyrosine phosphatase receptor type Z polypeptide 1; Protein-tyrosine phosphatase receptor type Z polypeptide 2; R-PTP-zeta-2; Precursor 12690205 12853948 1323835 16335952 21406692 2169617 2170109 8387522 9653645 NA PTPRZ -1 Receptor-type tyrosine-protein phosphatase zeta R-PTP-zeta 3.1.3.48 Protein-tyrosine phosphatase receptor type Z polypeptide 1 Protein-tyrosine phosphatase receptor type Z polypeptide 2 R-PTP-zeta-2 Precursor gene 1291 0.00106232178122635 GGCT N - Not Matched cytosol IDA xenobiotic metabolic process TAS glutathione biosynthetic process TAS release of cytochrome c from mitochondria IMP gamma-glutamylcyclotransferase activity IDA protein homodimerization activity IDA Gamma-glutamylcyclotransferase; 2.3.2.4; Cytochrome c-releasing factor 21 14702039 15489334 16765912 17932939 18515354 21269460 NA GGCT 1 Gamma-glutamylcyclotransferase 2.3.2.4 Cytochrome c-releasing factor 21 gene 2405 0.00103201999785003 C - Cellular Fate and Organization intermediate filament IDA cell projection IEA leading edge IEA peroxisome IDA cytosol IDA muscle filament sliding TAS intermediate filament organization IEA astrocyte development IEA virus-host interaction IEA Bergmann glial cell differentiation IEA cell structure disassembly during apoptosis TAS structural constituent of eye lens IEA structural constituent of cytoskeleton IDA Vimentin 11243787 11889032 12458200 14702039 14762106 14996095 15164054 15489334 15592455 15846844 16964243 17081983 17924679 18220336 18669648 18691976 18811945 19270731 19608861 19690332 20068231 20176112 21269460 21406692 21465480 21746880 22119849 2251132 2323579 2472876 3371665 3467175 9150946 9175763 NA VIME -1 Vimentin gene 1291 0.0126331677876299 DAB2 C - Cellular Fate and Organization clathrin coated vesicle membrane IEA coated pit IDA apical plasma membrane IEA clathrin coat of coated pit IEA nucleus IEA negative regulation of protein binding IMP excretion IEA negative regulation of apoptosis IDA pinocytosis IEA positive regulation of cell migration IEA cell proliferation TAS positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP apoptosis IEA activation of JNK activity IEA protein transport IEA embryonic development (sensu Mammalia) IEA cellular morphogenesis during differentiation IEA endoderm development IEA positive regulation of receptor recycling IEA myeloid cell differentiation IEA Wnt receptor signaling pathway IEA positive regulation of transcription, DNA-dependent IMP negative regulation of transcription, DNA-dependent IMP positive regulation of transforming growth factor beta receptor signaling pathway IDA clathrin cage assembly IEA phosphatidylinositol-4,5-bisphosphate binding IEA SMAD binding IDA Disabled homolog 2; DOC-2; Differentially-expressed protein 2 10340382 10769163 11161789 11387212 11967127 12805222 14596919 15134832 15372022 15489334 16267015 16964243 16984970 18669648 19306879 20068231 21097498 21269460 21995445 22323290 22484487 22491013 8314147 8660969 9620555 NA DAB2 -1 Disabled homolog 2 DOC-2 Differentially-expressed protein 2 gene 1291 0.423117088320965 N - Not Matched integral to Golgi membrane IEA extracellular space TAS positive regulation of Notch signaling pathway IEA pattern specification process TAS positive regulation of protein binding IEA metal ion binding IEA Beta-1,3-N-acetylglucosaminyltransferase manic fringe; 2.4.1.222; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 10591208 10935626 14702039 15461802 15489334 9187150 NA MFNG -1 Beta-1,3-N-acetylglucosaminyltransferase manic fringe 2.4.1.222 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase gene 4292 1.0 MITF C - Cellular Fate and Organization protein complex IDA nucleus NAS negative regulation of apoptosis IEA cell fate commitment IEA protein complex assembly IDA bone remodeling IEA regulation of cell proliferation IEA osteoclast differentiation IEA eye development (sensu Vertebrata) IEA melanocyte differentiation NAS regulation of osteoclast differentiation IEA Wnt receptor signaling pathway IEA RNA polymerase II transcription factor activity, enhancer binding IEA chromatin binding IEA DNA binding IEA Microphthalmia-associated transcription factor; Class E basic helix-loop-helix protein 32; bHLHe32 10578055 10587587 10673502 10760582 10851256 11230166 14975237 15489334 15507434 16641997 18220336 18669648 20068231 20163701 22012259 22080950 22647378 8069297 8589691 9647758 NA MITF 0 Microphthalmia-associated transcription factor Class E basic helix-loop-helix protein 32 bHLHe32 TF 2154 0.00401808768260578 N - Not Matched Golgi apparatus IEA Protein PRRC1; Proline-rich and coiled-coil-containing protein 1 14702039 15489334 15541471 17974005 18669648 21269460 NA PRRC1 1 Protein PRRC1 Proline-rich and coiled-coil-containing protein 1 gene 1291 0.122303416601617 SIRPA C - Cellular Fate and Organization plasma membrane TAS integral to membrane IEA blood coagulation TAS cell adhesion TAS leukocyte migration TAS Tyrosine-protein phosphatase non-receptor type substrate 1; SHP substrate 1; SHPS-1; Brain Ig-like molecule with tyrosine-based activation motifs; Bit; CD172 antigen-like family member A; Inhibitory receptor SHPS-1; Macrophage fusion receptor; MyD-1 antigen; Signal-regulatory protein alpha-1; Sirp-alpha-1; Signal-regulatory protein alpha-2; Sirp-alpha-2; Signal-regulatory protein alpha-3; Sirp-alpha-3; p84; CD172a; Precursor 10469599 10585853 10842184 11509594 11780052 14702039 15489334 16335952 17369261 18657508 19159218 9062191 9070220 9485180 NA SHPS1 -1 Tyrosine-protein phosphatase non-receptor type substrate 1 SHP substrate 1 SHPS-1 Brain Ig-like molecule with tyrosine-based activation motifs Bit CD172 antigen-like family member A Inhibitory receptor SHPS-1 Macrophage fusion receptor MyD-1 antigen Signal-regulatory protein alpha-1 Sirp-alpha-1 Signal-regulatory protein alpha-2 Sirp-alpha-2 Signal-regulatory protein alpha-3 Sirp-alpha-3 p84 CD172a Precursor gene 1291 0.0198413639010022 TPPP3 C - Cellular Fate and Organization cytoplasm IEA microtubule IEA microtubule bundle formation IDA tubulin binding IDA Tubulin polymerization-promoting protein family member 3; TPPP/p20 10810093 10931946 15489334 17105200 19633818 NA TPPP3 -1 Tubulin polymerization-promoting protein family member 3 TPPP/p20 gene 1291 0.0178778291877126 N - Not Matched integral to membrane IEA Transmembrane protein 140 12690205 12853948 14702039 15489334 16959974 NA TM140 -1 Transmembrane protein 140 gene 1291 0.00997161185978084 NPAS2 T - Transcription transcription factor complex IPI cytosol TAS locomotor rhythm IEA circadian sleep/wake cycle IEA positive regulation of transcription from RNA polymerase II promoter IGI central nervous system development TAS transcription, DNA-dependent IEA cellular lipid metabolic process TAS transcription factor activity TAS Hsp90 protein binding IDA signal transducer activity IEA DNA binding IPI Neuronal PAS domain-containing protein 2; Neuronal PAS2; Basic-helix-loop-helix-PAS protein MOP4; Class E basic helix-loop-helix protein 9; bHLHe9; Member of PAS protein 4; PAS domain-containing protein 4 12655319 15489334 15815621 9012850 9079689 NA NPAS2 1 Neuronal PAS domain-containing protein 2 Neuronal PAS2 Basic-helix-loop-helix-PAS protein MOP4 Class E basic helix-loop-helix protein 9 bHLHe9 Member of PAS protein 4 PAS domain-containing protein 4 gene 1291 0.0586146050434715 A - Transport and Sensing Golgi trans face IEA Golgi membrane TAS SNARE complex IEA integral to membrane IEA lysosome TAS endosome TAS Golgi to plasma membrane protein transport IEA regulation of Golgi to plasma membrane protein transport IEA Vesicle-associated membrane protein 4; VAMP-4 15489334 16710414 17081983 18318008 18669648 18691976 19690332 20068231 21269460 21406692 9553086 NA VAMP4 -1 Vesicle-associated membrane protein 4 VAMP-4 gene 1291 0.020077089894473 MEOX2 T - Transcription cytoplasm IDA nuclear speck IEA somite specification IEA striated muscle development IEA circulation TAS palate development IEA multicellular organismal development TAS angiogenesis IEA sequence-specific DNA binding IDA transcription factor activity IEA Homeobox protein MOX-2; Growth arrest-specific homeobox; Mesenchyme homeobox 2 12853948 15489334 16335786 19266028 7607679 7713505 NA MEOX2 -1 Homeobox protein MOX-2 Growth arrest-specific homeobox Mesenchyme homeobox 2 gene 1291 0.0118402561230045 VAMP3 F - Protein Fate clathrin coated vesicle membrane IEA neuron projection IEA apical plasma membrane IEA cell junction IEA plasma membrane ISS clathrin-coated vesicle IDA synapse IEA SNARE complex IEA integral to membrane TAS secretory granule IEA protein complex assembly TAS membrane fusion TAS Golgi to plasma membrane protein transport IEA calcium ion-dependent exocytosis IEA positive regulation of receptor recycling ISS retrograde transport, endosome to Golgi IDA vesicle docking during exocytosis TAS Vesicle-associated membrane protein 3; VAMP-3; Cellubrevin; CEB; Synaptobrevin-3 12665801 15489334 16710414 18195106 21269460 9885218 NA VAMP3 -1 Vesicle-associated membrane protein 3 VAMP-3 Cellubrevin CEB Synaptobrevin-3 gene 1291 0.373620399551778 NFASC C - Cellular Fate and Organization intracellular ISS initial segment ISS plasma membrane TAS integral to membrane IEA paranodal junction assembly IEA synapse organization and biogenesis IEA axon guidance TAS myelination ISS peripheral nervous system development ISS cell adhesion IEA Neurofascin; Precursor 12168954 14702039 15489334 15491607 16710414 17974005 18669648 21047790 9872452 NA NFASC -1 Neurofascin Precursor gene 1291 0.0580578706980573 DIAPH2 C - Cellular Fate and Organization mitochondrion IDA Golgi apparatus IDA nucleolus IDA early endosome IEA cytosol IEA cytokinesis TAS oogenesis IEA actin filament polymerization IEA multicellular organismal development IEA female gamete generation TAS cell differentiation IEA receptor binding TAS Protein diaphanous homolog 2; Diaphanous-related formin-2; DRF2 12577064 15772651 21269460 9497258 NA DIAP2 -1 Protein diaphanous homolog 2 Diaphanous-related formin-2 DRF2 gene 1946 1.0 POU3F2 C - Cellular Fate and Organization transcription factor complex IEA neurohypophysis development IEA positive regulation of cell proliferation IDA epidermis development IEA astrocyte development IEA neuron differentiation IEA myelination in the peripheral nervous system IEA forebrain ventricular zone progenitor cell division IEA cerebral cortex radially oriented migration IEA hypothalamus cell differentiation IEA positive regulation of body size IEA regulation of axonogenesis IEA sequence-specific DNA binding IEA transcription factor activity TAS POU domain, class 3, transcription factor 2; Brain-specific homeobox/POU domain protein 2; Brain-2; Brn-2; Nervous system-specific octamer-binding transcription factor N-Oct-3; Octamer-binding protein 7; Oct-7; Octamer-binding transcription factor 7; OTF-7 10332029 14574404 15489334 19690332 2739723 7651733 8441633 NA PO3F2 0 POU domain, class 3, transcription factor 2 Brain-specific homeobox/POU domain protein 2 Brain-2 Brn-2 Nervous system-specific octamer-binding transcription factor N-Oct-3 Octamer-binding protein 7 Oct-7 Octamer-binding transcription factor 7 OTF-7 TF 1291 0.163769497520013 PTGES C - Cellular Fate and Organization perinuclear region IEA nuclear envelope lumen IEA integral to membrane IDA signal transduction NAS response to calcium ion IEA acute inflammatory response IEA negative regulation of cell proliferation IEA prostaglandin biosynthetic process IDA response to lipopolysaccharide IEA chronic inflammatory response IEA glutathione binding IDA prostaglandin-E synthase activity IDA Prostaglandin E synthase; 5.3.99.3; Microsomal glutathione S-transferase 1-like 1; MGST1-L1; Microsomal prostaglandin E synthase 1; MPGES-1; p53-induced gene 12 protein 10377395 10760517 12460774 12672824 14702039 15164053 15489334 18682561 21269460 9305847 NA PTGES 1 Prostaglandin E synthase 5.3.99.3 Microsomal glutathione S-transferase 1-like 1 MGST1-L1 Microsomal prostaglandin E synthase 1 MPGES-1 p53-induced gene 12 protein gene 1291 0.0244174348753505 D - Genome Maintenance nucleoplasm TAS cytosol TAS protein complex assembly IEA organ morphogenesis IEA M/G1 transition of mitotic cell cycle TAS negative regulation of DNA replication IDA negative regulation of progression through cell cycle IDA negative regulation of transcription, DNA-dependent IDA transcription corepressor activity IEA Geminin 14574404 14702039 14993212 15260975 15313623 15378034 15489334 18669648 19608861 19906994 20068231 21543332 22615398 9635433 NA GEMI 1 Geminin gene 1291 0.0347288524571649 ILF2 T - Transcription cytoplasm IEA ribonucleoprotein complex IDA nucleolus IDA immune response IEA positive regulation of transcription, DNA-dependent IDA transcription, DNA-dependent IDA double-stranded RNA binding IDA ATP binding IEA DNA binding IDA transferase activity IEA Interleukin enhancer-binding factor 2; Nuclear factor of activated T-cells 45 kDa 10574923 11739746 11790298 12429849 14702039 15489334 16710414 17289661 17525332 17890166 21269460 7519613 9442054 NA ILF2 1 Interleukin enhancer-binding factor 2 Nuclear factor of activated T-cells 45 kDa gene 1291 7.91637519637533E-4 ODR4 N - Not Matched integral to membrane IEA oxidoreductase activity IEA zinc ion binding IEA Protein odr-4 homolog; hODR-4; LAG1-interacting protein; Transactivated by transforming growth factor beta protein 1 14702039 15489334 15718105 16710414 NA ODR4 1 Protein odr-4 homolog hODR-4 LAG1-interacting protein Transactivated by transforming growth factor beta protein 1 gene 1291 0.0278647230913388 FKBP3 P - Translation membrane IBA nucleus IBA protein folding IEA peptidyl-prolyl cis-trans isomerase activity IBA FK506 binding IBA receptor activity TAS Peptidyl-prolyl cis-trans isomerase FKBP3; PPIase FKBP3; 5.2.1.8; 25 kDa FK506-binding protein; 25 kDa FKBP; FKBP-25; FK506-binding protein 3; FKBP-3; Immunophilin FKBP25; Rapamycin-selective 25 kDa immunophilin; Rotamase 1374240 1375932 1376117 14702039 15489334 17081983 18669648 19608861 20068231 21269460 NA FKBP3 1 Peptidyl-prolyl cis-trans isomerase FKBP3 PPIase FKBP3 5.2.1.8 25 kDa FK506-binding protein 25 kDa FKBP FKBP-25 FK506-binding protein 3 FKBP-3 Immunophilin FKBP25 Rapamycin-selective 25 kDa immunophilin Rotamase gene 1291 0.0714360801321983 CLDN18 C - Cellular Fate and Organization plasma membrane IEA tight junction ISS integral to membrane IEA calcium-independent cell-cell adhesion ISS structural molecule activity IEA identical protein binding ISS Claudin-18 11585919 12975309 15489334 NA CLD18 -1 Claudin-18 gene 1291 0.51353529755696 MYRF T - Transcription nucleus ISS integral to membrane IEA myelin maintenance in the central nervous system ISS positive regulation of transcription, DNA-dependent ISS transcription, DNA-dependent IEA positive regulation of myelination ISS transcription factor activity IEA DNA binding IEA Myelin regulatory factor; Myelin gene regulatory factor 10231032 10828591 12168954 19608861 9615227 NA MRF -1 Myelin regulatory factor Myelin gene regulatory factor gene 1291 0.123378846497975 C1orf21 Uncharacterized protein C1orf21; Cell proliferation-inducing gene 13 protein 11318611 14702039 15489334 16710414 18669648 19690332 NA CA021 -1 Uncharacterized protein C1orf21 Cell proliferation-inducing gene 13 protein gene 1749 0.0657251629046597 PDE5A C - Cellular Fate and Organization cytosol TAS signal transduction NAS blood coagulation TAS positive regulation of MAPK activity IEA cGMP catabolic process IDA negative regulation of T cell proliferation IEA cGMP binding TAS 3',5'-cyclic-nucleotide phosphodiesterase activity NAS 3',5'-cyclic-GMP phosphodiesterase activity IEA zinc ion binding NAS cGMP-specific 3',5'-cyclic phosphodiesterase; 3.1.4.35; cGMP-binding cGMP-specific phosphodiesterase; CGB-PDE 10393044 11723116 12955149 14702039 15489334 15815621 9642111 9714779 9716380 NA PDE5A -1 cGMP-specific 3',5'-cyclic phosphodiesterase 3.1.4.35 cGMP-binding cGMP-specific phosphodiesterase CGB-PDE gene 1291 0.0617829085001869 HPRT1 M - Other Metabolism cytosol IBA central nervous system neuron development IEA positive regulation of dopamine metabolic process IMP guanine salvage IDA dendrite morphogenesis IEA purine ribonucleoside salvage IMP striatum development IEA response to amphetamine IEA adenine salvage IBA dopamine metabolic process IEA protein homotetramerization IDA IMP salvage IBA cytolysis IEA GMP salvage IBA GMP catabolic process IDA behavior IMP hypoxanthine salvage IDA lymphocyte proliferation IEA grooming behavior IEA cerebral cortex neuron differentiation IEA magnesium ion binding IDA nucleotide binding IEA hypoxanthine phosphoribosyltransferase activity IDA Hypoxanthine-guanine phosphoribosyltransferase; HGPRT; HGPRTase; 2.4.2.8 10338013 10360366 1301916 14702039 1487231 15489334 1551676 15772651 15990111 1840476 1937471 19527031 2018042 2071157 21269460 2246854 2341149 2347587 2358296 2572141 2738157 2896620 2909537 2910902 2928313 3023844 3148064 3198771 3265398 3358423 3384338 6300847 6572373 6706936 6853490 6853716 7107641 7627191 8044844 9003484 9452051 NA HPRT 1 Hypoxanthine-guanine phosphoribosyltransferase HGPRT HGPRTase 2.4.2.8 gene 1291 0.00401808768260578 DGKZ D - Genome Maintenance cytoplasm IEA plasma membrane TAS nucleus IDA lamellipodium IDA negative regulation of Ras protein signal transduction IEA cell migration NAS negative regulation of progression through mitotic cell cycle IGI platelet activation TAS G1 DNA damage checkpoint IGI protein kinase C activation IEA enzyme inhibitor activity IEA diacylglycerol kinase activity IEA lipid kinase activity IDA protein C-terminus binding IDA ATP binding TAS metal ion binding IEA Diacylglycerol kinase zeta; DAG kinase zeta; 2.7.1.107; Diglyceride kinase zeta; DGK-zeta 11257115 11352924 14702039 15489334 16554811 17351151 8626588 9159104 9716136 NA DGKZ 1 Diacylglycerol kinase zeta DAG kinase zeta 2.7.1.107 Diglyceride kinase zeta DGK-zeta gene 1291 0.0781675657111357 HBEGF C - Cellular Fate and Organization cell surface NAS integral to plasma membrane TAS extracellular space TAS negative regulation of elastin biosynthetic process IEA positive regulation of protein kinase B signaling cascade IMP muscle development TAS positive regulation of cell migration IMP wound healing, spreading of epidermal cells IEA epidermal growth factor receptor signaling pathway IMP positive regulation of keratinocyte migration IEA positive regulation of cell growth IEA regulation of heart contraction IEA positive regulation of smooth muscle cell proliferation IEA epidermal growth factor receptor binding TAS eukaryotic cell surface binding IDA heparin binding IMP Proheparin-binding EGF-like growth factor; Heparin-binding EGF-like growth factor; HB-EGF; HBEGF; Diphtheria toxin receptor; DT-R; Precursor 14702039 15372022 15489334 1556128 16508205 1840698 22171320 23234360 7836353 9135143 9659904 NA HBEGF -1 Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor HB-EGF HBEGF Diphtheria toxin receptor DT-R Precursor gene 1291 0.00323169906125048 ARL6IP1 P - Translation translocon complex IEA endoplasmic reticulum IDA integral to membrane IEA cytosol IEA cotranslational protein targeting to membrane IEA ADP-ribosylation factor-like protein 6-interacting protein 1; ARL-6-interacting protein 1; Aip-1 10995579 15489334 7584044 NA AR6P1 1 ADP-ribosylation factor-like protein 6-interacting protein 1 ARL-6-interacting protein 1 Aip-1 gene 1291 0.00348473781211124 GPT2 N - Not Matched mitochondrial matrix TAS L-alanine metabolic process IDA 2-oxoglutarate metabolic process IDA L-alanine catabolic process IEA amino acid biosynthetic process TAS alanine transaminase activity IDA pyridoxal phosphate binding IEA Alanine aminotransferase 2; ALT2; 2.6.1.2; Glutamate pyruvate transaminase 2; GPT 2; Glutamic--alanine transaminase 2; Glutamic--pyruvic transaminase 2 11863375 14702039 15489334 15616553 21269460 NA ALAT2 1 Alanine aminotransferase 2 ALT2 2.6.1.2 Glutamate pyruvate transaminase 2 GPT 2 Glutamic--alanine transaminase 2 Glutamic--pyruvic transaminase 2 gene 1291 0.00556253733701826 C - Cellular Fate and Organization cytoplasm IDA plasma membrane IDA microtubule IDA protein polymerization IEA posttranslational protein folding TAS microtubule-based movement IEA structural molecule activity IEA GTPase activity IEA GTP binding IEA Tubulin beta-6 chain 14702039 15489334 19524510 19690332 20191564 21269460 21406692 NA TBB6 -1 Tubulin beta-6 chain gene 2871 1.0 RARB C - Cellular Fate and Organization cytoplasm IEA nucleoplasm TAS ureteric bud development IEA positive regulation of apoptosis IEA negative regulation of cell proliferation IEA transcription initiation from RNA polymerase II promoter TAS ventricular cardiac muscle cell differentiation IEA embryonic gut development IMP negative regulation of transcription from RNA polymerase II promoter IEA striatum development IEA body growth IEA positive regulation of transcription from RNA polymerase II promoter IEA embryonic hindlimb morphogenesis IEA negative regulation of chondrocyte differentiation IEA neurogenesis IEA embryonic eye morphogenesis IEA sequence-specific DNA binding IEA steroid hormone receptor activity IEA zinc ion binding IEA retinoic acid receptor activity TAS DNA binding TAS Retinoic acid receptor beta; RAR-beta; HBV-activated protein; Nuclear receptor subfamily 1 group B member 2; RAR-epsilon 10411930 12554770 1321662 15489334 1663808 16959974 2170809 2825037 2833708 2836738 3014347 8275470 8383553 NA RARB 0 Retinoic acid receptor beta RAR-beta HBV-activated protein Nuclear receptor subfamily 1 group B member 2 RAR-epsilon TF 1741 1.0 RARA D - Genome Maintenance cytoplasm IDA nuclear chromatin IDA cell surface IC cell soma IEA nucleoplasm TAS dendrite IEA ureteric bud development IEA positive regulation of protein kinase B signaling cascade IEA positive regulation of cell proliferation IMP positive regulation of interleukin-4 production IDA transcription initiation from RNA polymerase II promoter TAS positive regulation of interleukin-5 production IDA ventricular cardiac muscle cell differentiation IEA spermatogenesis IEA positive regulation of interleukin-13 production IDA germ cell development IEA body growth IEA positive regulation of transcription from RNA polymerase II promoter IDA negative regulation of translational initiation IEA negative regulation of granulocyte differentiation IDA positive regulation of T-helper 2 cell differentiation IDA response to estradiol stimulus IDA negative regulation of interferon-gamma production IDA positive regulation of binding IMP apoptotic cell clearance IMP negative regulation of tumor necrosis factor-alpha production IDA positive regulation of phosphoinositide 3-kinase cascade IEA negative regulation of transcription from RNA polymerase II promoter IEA positive regulation of progression through cell cycle IMP protein amino acid phosphorylation IMP Sertoli cell fate commitment IEA negative regulation of transcription, DNA-dependent IDA estrogen receptor signaling pathway IDA sequence-specific DNA binding IEA protein heterodimerization activity IDA phosphoinositide 3-kinase regulator activity IEA transcription corepressor activity IDA transcription coactivator activity IDA retinoic acid binding IDA receptor binding IDA steroid hormone receptor activity IEA zinc ion binding IEA retinoic acid receptor activity IDA protein kinase A binding IDA chromatin DNA binding IDA Retinoic acid receptor alpha; RAR-alpha; Nuclear receptor subfamily 1 group B member 1 10337631 10567404 10698945 10882070 11812818 11971969 12039952 12691149 15489334 15809060 16179254 16417524 16606617 16625196 17455211 19377461 19850744 20215566 20543827 2175878 2825025 2825036 8302850 8562957 9267036 NA RARA 0 Retinoic acid receptor alpha RAR-alpha Nuclear receptor subfamily 1 group B member 1 TF 1291 0.033765772778368 TPI1 E - Energy Production cytosol TAS glyceraldehyde-3-phosphate metabolic process IEA gluconeogenesis TAS embryonic development IEA pentose-phosphate shunt IEA glycolysis TAS triose-phosphate isomerase activity NAS Triosephosphate isomerase; TIM; 5.3.1.1; Triose-phosphate isomerase 1339398 14702039 15489334 16511037 16541075 16807684 17081983 17693683 17924679 18562316 18669648 19367720 19608861 19690332 20068231 21269460 21406692 2579079 2876430 2925688 4022011 6434534 8061610 8503454 8571957 8723724 9074930 9150946 9150948 9338582 NA TPIS 1 Triosephosphate isomerase TIM 5.3.1.1 Triose-phosphate isomerase gene 1291 0.0109363272005778 C - Cellular Fate and Organization mitochondrial intermembrane space IEA Golgi apparatus IEA peroxisomal matrix TAS plasma membrane IEA endoplasmic reticulum IEA lysosome IEA peroxisomal membrane ISS cytosol IEA response to hypoxia IEA UV protection IMP negative regulation of apoptosis IMP hemoglobin metabolic process IEA positive regulation of phosphoinositide 3-kinase cascade IEA inhibition of NF-kappaB transcription factor IEA menopause IEA aerobic respiration IEA purine nucleotide catabolic process TAS activation of NF-kappaB transcription factor IEA protein homotetramerization IDA purine base metabolic process TAS triacylglycerol metabolic process IEA positive regulation of cell division IEA hydrogen peroxide catabolic process IDA cholesterol metabolic process IEA NADP binding IDA catalase activity IDA aminoacylase activity IEA protein homodimerization activity IDA metal ion binding IEA heme binding IDA Catalase; 1.11.1.6 10656833 10666617 11134921 11728823 12665801 14702039 15489334 16554811 18088087 19608861 21269460 2308162 3755525 3755526 6548744 7882369 8282800 NA CATA -1 Catalase 1.11.1.6 gene 1291 0.136068548786856 DHTKD1 E - Energy Production mitochondrion IEA tricarboxylic acid cycle IEA glycolysis IEA thiamin pyrophosphate binding IEA oxoglutarate dehydrogenase (succinyl-transferring) activity IEA Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial; 1.2.4.2; Dehydrogenase E1 and transketolase domain-containing protein 1; Precursor 10997877 15164054 15489334 17974005 NA DHTK1 1 Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial 1.2.4.2 Dehydrogenase E1 and transketolase domain-containing protein 1 Precursor gene 6571 1.0 HIF1A C - Cellular Fate and Organization transcription factor complex IPI nucleolus IDA cytosol TAS hemoglobin biosynthetic process IEA positive regulation of vascular endothelial growth factor receptor signaling pathway IC negative regulation of TOR signaling pathway IEA cerebral cortex development IEA cartilage development IEA neural crest cell migration IEA epithelial to mesenchymal transition ISS elastin metabolic process ISS muscle maintenance IEA heart looping IEA iron ion homeostasis IEA negative regulation of neuron apoptosis IEA Notch signaling pathway TAS positive regulation of hormone biosynthetic process IDA mRNA transcription from RNA polymerase II promoter IC B-1 B cell homeostasis IEA positive regulation of glycolysis IC embryonic hemopoiesis IEA negative regulation of growth IEA lactate metabolic process IEA neural fold elevation formation IEA positive regulation of neuroblast proliferation IEA embryonic placenta development IEA regulation of transcription from RNA polymerase II promoter in response to oxidative stress IDA connective tissue replacement during inflammatory response ISS glucose homeostasis IEA positive regulation of chemokine production TAS angiogenesis IEA negative regulation of bone mineralization IEA digestive tract morphogenesis IEA positive regulation of angiogenesis IC positive regulation of endothelial cell proliferation IC lactation IEA positive regulation of erythrocyte differentiation IC positive regulation of nitric-oxide synthase activity TAS visual learning IEA axon transport of mitochondrion IMP oxygen homeostasis IDA sequence-specific DNA binding IEA protein heterodimerization activity TAS RNA polymerase II transcription factor activity, enhancer binding IDA Hsp90 protein binding IDA signal transducer activity IEA Hypoxia-inducible factor 1-alpha; HIF-1-alpha; HIF1-alpha; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; Class E basic helix-loop-helix protein 78; bHLHe78; Member of PAS protein 1; PAS domain-containing protein 8 10202154 10594042 10758161 10944113 11006129 11089639 11292861 11389899 11566883 11959977 11959990 12004076 12050673 12080085 12351678 12446723 12464182 12508121 12560087 12778114 12914934 14757845 15465032 15489334 15776016 16288748 16543236 16862177 16973622 17244529 17610843 17956732 18638657 18658046 18781797 19046997 19528298 20624928 20699359 20889502 22128162 22286099 7539918 8917528 9079689 9235919 9653127 9782081 9822602 9887100 NA HIF1A 0 Hypoxia-inducible factor 1-alpha HIF-1-alpha HIF1-alpha ARNT-interacting protein Basic-helix-loop-helix-PAS protein MOP1 Class E basic helix-loop-helix protein 78 bHLHe78 Member of PAS protein 1 PAS domain-containing protein 8 TF 3473 0.00440280112467335 PDE4B C - Cellular Fate and Organization perinuclear region IEA nucleus IEA cytosol TAS neutrophil homeostasis IEA signal transduction IEA neutrophil chemotaxis IEA cAMP catabolic process IEA 3',5'-cyclic-AMP phosphodiesterase activity TAS metal ion binding IEA cAMP-specific 3',5'-cyclic phosphodiesterase 4B; 3.1.4.17; DPDE4; PDE32 10846163 14702039 15003452 15260978 15489334 15576036 15685167 16710414 17727341 18539455 8384210 8392015 8413254 9371714 NA PDE4B -1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B 3.1.4.17 DPDE4 PDE32 gene 1291 0.0994998451839461 CSF3 C - Cellular Fate and Organization extracellular space TAS positive regulation of protein kinase B signaling cascade IDA immune response IEA positive regulation of cell proliferation TAS positive regulation of actin filament polymerization IDA positive regulation of transcription from RNA polymerase II promoter IDA cytokine and chemokine mediated signaling pathway NAS positive regulation of peptidyl-tyrosine phosphorylation IDA positive regulation of phosphoinositide 3-kinase cascade IDA granulocyte differentiation NAS positive regulation of transcription factor import into nucleus IDA positive regulation of protein binding IDA granulocyte colony-stimulating factor receptor binding TAS cytokine activity NAS Granulocyte colony-stimulating factor; G-CSF; Pluripoietin; Filgrastim; Lenograstim; Precursor 10537111 1281794 15028279 16492764 16625196 2420009 2423327 3484805 3494801 7518249 7685117 7685769 8554326 NA CSF3 -1 Granulocyte colony-stimulating factor G-CSF Pluripoietin Filgrastim Lenograstim Precursor gene 1291 0.274618126864437 SLCO2B1 A - Transport and Sensing apical plasma membrane IEA plasma membrane TAS integral to membrane IEA sodium-independent organic anion transport TAS sodium-independent organic anion transporter activity IDA Solute carrier organic anion transporter family member 2B1; Organic anion transporter B; OATP-B; Organic anion transporter polypeptide-related protein 2; OATP-RP2; OATPRP2; Solute carrier family 21 member 9 10048485 10873595 15489334 16554811 16754786 16959974 17974005 NA SO2B1 -1 Solute carrier organic anion transporter family member 2B1 Organic anion transporter B OATP-B Organic anion transporter polypeptide-related protein 2 OATP-RP2 OATPRP2 Solute carrier family 21 member 9 gene 1291 0.00231151180858288 C - Cellular Fate and Organization membrane IEA chromosome IEA nucleus IDA extracellular space IDA basement membrane ISS response to hypoxia ISS aging TAS histone modification IDA sprouting angiogenesis IMP epithelial to mesenchymal transition IDA transcription, DNA-dependent IEA endothelial cell migration IMP collagen fibril organization IMP endothelial cell proliferation IMP positive regulation of chondrocyte differentiation ISS response to copper ion IDA cell adhesion TAS negative regulation of transcription, DNA-dependent IDA protein amino acid deamination IDA copper ion binding IEA chromatin binding IDA transcription corepressor activity IDA protein-lysine 6-oxidase activity IDA electron carrier activity TAS methylated histone residue binding IDA scavenger receptor activity IEA Lysyl oxidase homolog 2; 1.4.3.13; Lysyl oxidase-like protein 2; Lysyl oxidase-related protein 2; Lysyl oxidase-related protein WS9-14; Precursor 10212285 14702039 15489334 16096638 16421571 20026874 20306300 20439985 20818376 21233336 21732535 21835952 22157764 22483618 23319596 9079631 NA LOXL2 1 Lysyl oxidase homolog 2 1.4.3.13 Lysyl oxidase-like protein 2 Lysyl oxidase-related protein 2 Lysyl oxidase-related protein WS9-14 Precursor gene 1291 1.08611405269208E-5 C - Cellular Fate and Organization protein complex IEA terminal button ISS cell soma ISS nuclear matrix IDA cytosol IDA pregnancy IEA drug metabolic process ISS organ regeneration IEA embryonic development IEA response to cortisol stimulus IEA UTP biosynthetic process IEA protein amino acid autophosphorylation ISS pyrimidine nucleoside biosynthetic process TAS response to caffeine IEA lactation IEA peptidyl-threonine phosphorylation ISS glutamine catabolic process IEA 'de novo' pyrimidine base biosynthetic process ISS glutamine metabolic process ISS aspartate carbamoyltransferase activity ISS protein kinase activity ISS dihydroorotase activity ISS carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity ISS ATP binding ISS metal ion binding IEA identical protein binding ISS CAD protein; Glutamine-dependent carbamoyl-phosphate synthase; 6.3.5.5; Aspartate carbamoyltransferase; 2.1.3.2; Dihydroorotase; 3.5.2.3 15489334 16959974 16964243 17081983 18669648 18691976 19608861 19690332 1979741 20068231 21269460 21406692 8619816 NA PYR1 1 CAD protein Glutamine-dependent carbamoyl-phosphate synthase 6.3.5.5 Aspartate carbamoyltransferase 2.1.3.2 Dihydroorotase 3.5.2.3 gene 1291 0.199549309027409 N - Not Matched Golgi membrane TAS integral to membrane IEA O-glycan processing TAS polypeptide N-acetylgalactosaminyltransferase activity IEA metal ion binding IEA Polypeptide N-acetylgalactosaminyltransferase 10; 2.4.1.41; Polypeptide GalNAc transferase 10; GalNAc-T10; pp-GaNTase 10; Protein-UDP acetylgalactosaminyltransferase 10; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10 12417297 12693554 14702039 15489334 16650853 17974005 NA GLT10 1 Polypeptide N-acetylgalactosaminyltransferase 10 2.4.1.41 Polypeptide GalNAc transferase 10 GalNAc-T10 pp-GaNTase 10 Protein-UDP acetylgalactosaminyltransferase 10 UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10 gene 1291 0.495374170526184 SORBS1 D - Genome Maintenance zonula adherens TAS stress fiber ISS centrosome IDA plasma membrane IDA nucleus IDA lipid raft ISS focal adhesion IDA nuclear matrix IEA cytosol ISS insulin receptor signaling pathway ISS positive regulation of lipid biosynthetic process ISS muscle contraction TAS glucose transport ISS positive regulation of glycogen biosynthetic process ISS positive regulation of glucose import ISS focal adhesion formation ISS stress fiber formation ISS SH3/SH2 adaptor activity ISS insulin receptor binding IDA actin binding TAS Sorbin and SH3 domain-containing protein 1; Ponsin; SH3 domain protein 5; SH3P12; c-Cbl-associated protein; CAP 10718198 11230166 11371513 11374898 11532984 12504111 15164054 15489334 16959974 17462669 17784760 18669648 20068231 21406692 NA SRBS1 -1 Sorbin and SH3 domain-containing protein 1 Ponsin SH3 domain protein 5 SH3P12 c-Cbl-associated protein CAP gene 1291 0.00137163971806715 SNTA1 N - Not Matched intracellular IDA sarcolemma IEA cytoplasm IEA cell junction IEA postsynaptic membrane IEA cytoskeleton IEA muscle contraction TAS neuromuscular junction development IEA phospholipid binding IEA Alpha-1-syntrophin; 59 kDa dystrophin-associated protein A1 acidic component 1; Pro-TGF-alpha cytoplasmic domain-interacting protein 1; TACIP1; Syntrophin-1 10212242 10230395 11163757 11780052 14702039 15489334 17081983 18591664 18669648 19684871 20068231 8576247 8612778 NA SNTA1 1 Alpha-1-syntrophin 59 kDa dystrophin-associated protein A1 acidic component 1 Pro-TGF-alpha cytoplasmic domain-interacting protein 1 TACIP1 Syntrophin-1 gene 1291 0.364504426934328 KAT6B D - Genome Maintenance nucleosome NAS nucleosome assembly NAS positive regulation of transcription, DNA-dependent IDA negative regulation of transcription, DNA-dependent IDA transcription, DNA-dependent IEA zinc ion binding IEA DNA binding IEA histone acetyltransferase activity IDA transcription factor binding IDA Histone acetyltransferase KAT6B; 2.3.1.48; Histone acetyltransferase MOZ2; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4; MYST-4; Monocytic leukemia zinc finger protein-related factor 10497217 11157802 11965546 12168954 15489334 16387653 16959974 18794358 19608861 22077973 22265014 9205841 NA KAT6B -1 Histone acetyltransferase KAT6B 2.3.1.48 Histone acetyltransferase MOZ2 MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4 MYST-4 Monocytic leukemia zinc finger protein-related factor gene 1291 8.8149238852397E-5 HOXA5 C - Cellular Fate and Organization nucleus IDA positive regulation of apoptosis IDA alveolus development IEA embryonic skeletal morphogenesis IEA thyroid gland development IEA anterior/posterior pattern formation IEA transcription, DNA-dependent IEA cell migration IEA body growth IEA positive regulation of myeloid cell differentiation IDA negative regulation of erythrocyte differentiation IDA positive regulation of transcription from RNA polymerase II promoter IDA negative regulation of angiogenesis IMP sequence-specific DNA binding IEA transcription factor activity IDA DNA binding IDA Homeobox protein Hox-A5; Homeobox protein Hox-1C 12690205 12853948 15489334 18669648 2568583 2576652 NA HXA5 -1 Homeobox protein Hox-A5 Homeobox protein Hox-1C TF 1291 0.0750711142623216 C - Cellular Fate and Organization collagen TAS endoplasmic reticulum lumen TAS cell cortex IEA skeletal development TAS extracellular matrix organization and biogenesis TAS metal ion binding IEA Collagen alpha-1(X) chain; Precursor 11839302 1397333 14574404 15489334 1587271 15880705 1743401 1764025 2037056 7607655 7876225 8004099 8304336 8782043 9067753 9101290 9837818 9852679 NA COAA1 1 Collagen alpha-1(X) chain Precursor gene 2070 0.0020013975967909 C - Cellular Fate and Organization perinuclear region IDA endoplasmic reticulum IDA B cell differentiation IEP anatomical structure morphogenesis TAS secretion TAS protein heterodimerization activity IDA calcium ion binding IDA protein homodimerization activity IDA Tumor protein D52; Protein N8 14702039 14996714 15489334 16421571 17081983 17974005 18669648 20068231 21269460 21406692 7796418 8632896 9484778 NA TPD52 1 Tumor protein D52 Protein N8 gene 1291 0.308617760461342 A - Transport and Sensing rough endoplasmic reticulum IDA Golgi trans face IDA ER-Golgi intermediate compartment IDA perinuclear region IDA Golgi apparatus IDA brush border membrane IDA anchored to external side of plasma membrane IDA sarcolemma IEA apical plasma membrane IDA sarcoplasmic reticulum IEA transport vesicle membrane IDA secretory granule membrane IDA response to drug IEA bicarbonate transport IMP organ development IEA response to steroid hormone stimulus IEA one-carbon compound metabolic process IEA zinc ion binding IEA carbonate dehydratase activity TAS Carbonic anhydrase 4; 4.2.1.1; Carbonate dehydratase IV; Carbonic anhydrase IV; CA-IV; Precursor 1311094 15489334 15563508 16686544 16807956 17127057 17314045 17705204 18618712 19186056 19206230 20363633 2111324 7625839 8325641 8809084 8942978 NA CAH4 -1 Carbonic anhydrase 4 4.2.1.1 Carbonate dehydratase IV Carbonic anhydrase IV CA-IV Precursor gene 1291 0.00448150748680999 A - Transport and Sensing cytosol TAS bicarbonate transport TAS one-carbon compound metabolic process IEA response to oxidative stress IEA zinc ion binding IEA carbonate dehydratase activity TAS nickel ion binding IEA Carbonic anhydrase 3; 4.2.1.1; Carbonate dehydratase III; Carbonic anhydrase III; CA-III 14702039 15489334 16042381 17427958 18618712 19186056 19206230 2824285 3086182 3099285 9651514 NA CAH3 -1 Carbonic anhydrase 3 4.2.1.1 Carbonate dehydratase III Carbonic anhydrase III CA-III gene 1291 0.126227128319971 TMEM47 N - Not Matched plasma membrane IDA intercellular junction IEA integral to membrane IEA Transmembrane protein 47; Brain cell membrane protein 1; Transmembrane 4 superfamily member 10 11230166 15489334 15772651 NA TMM47 -1 Transmembrane protein 47 Brain cell membrane protein 1 Transmembrane 4 superfamily member 10 gene 1291 0.00448150748680999 A - Transport and Sensing microvillus IEA basolateral plasma membrane IEA axon IEA apical part of cell IDA extracellular space IEA cytosol TAS response to estrogen stimulus IEA kidney development IEA response to stress IEA positive regulation of osteoclast differentiation IEA carbon dioxide transport IEA response to zinc ion IEA secretion IEA positive regulation of bone resorption IEA bicarbonate transport TAS odontogenesis (sensu Vertebrata) IEA morphogenesis of an epithelium IEA one-carbon compound metabolic process IEA response to pH IEA zinc ion binding IDA carbonate dehydratase activity TAS Carbonic anhydrase 2; 4.2.1.1; Carbonate dehydratase II; Carbonic anhydrase C; CAC; Carbonic anhydrase II; CA-II 10550681 11015219 11076507 11327835 11572683 11802772 11818565 11831900 12056894 12166932 12171926 12499545 1336460 1433293 14567693 14702039 14736236 14736710 1474587 15218065 15299481 15299482 15300855 1542674 15453828 15489334 15667203 15865431 16106378 16134940 16214338 16290146 16506782 16511248 16686544 16759856 16787097 16807956 16820676 16942027 17000110 17071654 17125255 17127057 17181151 17251017 17314045 17319692 17330962 17346964 17407288 17540563 17588751 17705204 18024029 18161740 18162396 18260615 18266323 18359629 18374572 18461940 18481843 18618712 18640037 18723489 18768466 18942852 1909891 1910042 19115843 19170619 19186056 19206230 1928091 1932029 19520834 19583303 19731956 19778001 19827837 21269460 3000449 3108857 3121496 3151019 3151020 4207120 4621826 6407977 6817747 7608893 7696263 7761440 7803386 7901850 8070585 8142888 8218160 823150 8262987 8331673 8399159 8431430 8451242 8482389 8485129 8557623 8639494 8834238 8987974 9143915 9265618 9398308 9541386 9865942 NA CAH2 -1 Carbonic anhydrase 2 4.2.1.1 Carbonate dehydratase II Carbonic anhydrase C CAC Carbonic anhydrase II CA-II gene 1291 0.0517126829303475 CCDC167 N - Not Matched integral to membrane IEA Coiled-coil domain-containing protein 167 14574404 15489334 21269460 NA CC167 1 Coiled-coil domain-containing protein 167 gene 1291 0.00138693266328751 FIGF C - Cellular Fate and Organization membrane IEA platelet alpha granule lumen TAS extracellular space TAS induction of positive chemotaxis IDA vascular endothelial growth factor receptor signaling pathway TAS positive regulation of cell proliferation TAS cell proliferation IEA platelet degranulation TAS platelet activation TAS positive regulation of cell division IEA angiogenesis IEA cell differentiation IEA platelet-derived growth factor receptor binding TAS chemoattractant activity IDA Vascular endothelial growth factor D; VEGF-D; c-Fos-induced growth factor; FIGF; Precursor 10542248 14702039 15489334 21148085 9205122 9435229 9479493 NA VEGFD -1 Vascular endothelial growth factor D VEGF-D c-Fos-induced growth factor FIGF Precursor gene 1291 0.624335689084079 SYNPO C - Cellular Fate and Organization stress fiber IEA cytoplasm IEA plasma membrane IEA dendritic spine TAS postsynaptic membrane IEA postsynaptic density IEA perikaryon IEA tight junction IEA actin cytoskeleton ISS positive regulation of actin filament bundle formation IEA regulation of stress fiber formation IEA actin binding ISS Synaptopodin 10470851 12042308 14702039 15489334 15592455 17081983 17974005 18220336 18596123 18669648 19159218 20068231 9314539 NA SYNPO -1 Synaptopodin gene 1291 0.106951875741358 SLCO2A1 A - Transport and Sensing integral to plasma membrane TAS sodium-independent organic anion transport TAS prostaglandin transporter activity IEA lipid transporter activity TAS Solute carrier organic anion transporter family member 2A1; Prostaglandin transporter; PGT; Solute carrier family 21 member 2 15489334 22197487 22331663 22553128 22696055 8787677 9618293 NA SO2A1 -1 Solute carrier organic anion transporter family member 2A1 Prostaglandin transporter PGT Solute carrier family 21 member 2 gene 1291 0.158667429513406 ARAP2 C - Cellular Fate and Organization cytosol TAS positive regulation of GTPase activity IEA regulation of small GTPase mediated signal transduction TAS small GTPase mediated signal transduction TAS regulation of ARF GTPase activity IEA ARF GTPase activator activity IEA phosphatidylinositol-3,4,5-triphosphate binding IDA zinc ion binding IEA Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2; Centaurin-delta-1; Cnt-d1; Protein PARX 11804590 15815621 9628581 NA ARAP2 -1 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 Centaurin-delta-1 Cnt-d1 Protein PARX gene 1291 6.43402690293247E-6 ACYP1 C - Cellular Fate and Organization phosphate metabolic process TAS acylphosphatase activity TAS Acylphosphatase-1; 3.6.1.7; Acylphosphatase, erythrocyte isozyme; Acylphosphatase, organ-common type isozyme; Acylphosphate phosphohydrolase 1 12508121 14702039 15489334 16511269 19196981 21269460 3026468 7796909 NA ACYP1 -1 Acylphosphatase-1 3.6.1.7 Acylphosphatase, erythrocyte isozyme Acylphosphatase, organ-common type isozyme Acylphosphate phosphohydrolase 1 gene 1619 4.34914176439703E-6 FOSB T - Transcription nucleus IEA behavior TAS multicellular organismal development TAS negative regulation of transcription from RNA polymerase II promoter TAS sequence-specific DNA binding IEA transcription factor activity IEA DNA binding TAS transcription factor binding TAS Protein fosB; G0/G1 switch regulatory protein 3 1301997 14702039 15057824 15489334 8985116 NA FOSB -1 Protein fosB G0/G1 switch regulatory protein 3 gene 1291 1.0 CDC5L D - Genome Maintenance cytoplasm IEA nuclear speck IDA nucleolus IDA cell cycle IEA regulation of transcription, DNA-dependent NAS nuclear mRNA splicing, via spliceosome IC transcription, DNA-dependent IEA RNA binding IEA chromatin binding IEA DNA binding NAS Cell division cycle 5-like protein; Cdc5-like protein; Pombe cdc5-related protein 10570151 10827081 11082045 11101529 11544257 11991638 12168954 12927788 14574404 15489334 17081983 18220336 18583928 18669648 18722174 19690332 20068231 20176811 21269460 21385873 21406692 8917598 9038199 9455477 9468527 9598309 9632794 9731529 NA CDC5L 0 Cell division cycle 5-like protein Cdc5-like protein Pombe cdc5-related protein TF 1291 0.00458749974480071 EIF2AK1 C - Cellular Fate and Organization cytoplasm IEA response to external stimulus IEP negative regulation of translational initiation by iron NAS negative regulation of cell proliferation IEA protein amino acid autophosphorylation ISS response to stress IEP protoporphyrinogen IX metabolic process IEA negative regulation of hemoglobin biosynthetic process ISS ATP binding IEA eukaryotic translation initiation factor 2alpha kinase activity IDA protein homodimerization activity ISS heme binding ISS Eukaryotic translation initiation factor 2-alpha kinase 1; 2.7.11.1; Heme-controlled repressor; HCR; Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase; Heme-regulated inhibitor; Hemin-sensitive initiation factor 2-alpha kinase 10718198 10931946 11036079 11101152 11230166 12391722 12690205 14702039 15489334 17344846 17974005 18691976 20071449 21269460 NA E2AK1 1 Eukaryotic translation initiation factor 2-alpha kinase 1 2.7.11.1 Heme-controlled repressor HCR Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase Heme-regulated inhibitor Hemin-sensitive initiation factor 2-alpha kinase gene 1736 0.00146672727586885 IL6 D - Genome Maintenance interleukin-6 receptor complex IDA extracellular space IDA external side of plasma membrane IEA positive regulation of interleukin-6 production IDA response to heat IEA defense response to Gram-positive bacterium IEP negative regulation of fat cell differentiation NAS regulation of cell shape IEA response to cold IEA positive regulation of transmission of nerve impulse IEA neurite development IMP negative regulation of hormone secretion IEA defense response to virus IDA bone remodeling IEA response to electrical stimulus IEA negative regulation of chemokine biosynthetic process ISS response to lipopolysaccharide IEA response to nutrient levels IEA response to antibiotic IEA positive regulation of epithelial cell proliferation IEA positive regulation of DNA replication IEA aging IEA defense response to protozoan IEA platelet activation TAS response to glucocorticoid stimulus IDA acute-phase response TAS positive regulation of chemokine production IDA response to calcium ion IEA negative regulation of muscle development IEA T cell activation IEA positive regulation of B cell activation IDA cell growth IEA cell redox homeostasis IEA neutrophil apoptosis IDA positive regulation of protein kinase B signaling cascade IEA negative regulation of cell proliferation TAS regulation of circadian sleep/wake cycle, non-REM sleep IEA negative regulation of cytokine secretion IEA muscle maintenance IEA positive regulation of nitric oxide biosynthetic process IEA positive regulation of transcription factor activity IDA response to caffeine IEA positive regulation of acute inflammatory response IDA hepatic immune response IDA humoral immune response IC positive regulation of transcription from RNA polymerase II promoter IDA positive regulation of T cell proliferation IDA negative regulation of caspase activity IEA response to amino acid stimulus IEA positive regulation of T-helper 2 cell differentiation IEA negative regulation of gluconeogenesis IEA negative regulation of apoptosis IDA neutrophil mediated immunity IC positive regulation of tyrosine phosphorylation of Stat3 protein IDA response to drug IEA regulation of angiogenesis IC positive regulation of protein biosynthetic process IDA positive regulation of smooth muscle cell proliferation IDA positive regulation of leukocyte chemotaxis IC monocyte chemotaxis IC response to mechanical stimulus IEA positive regulation of osteoblast differentiation TAS defense response to Gram-negative bacterium IEP positive regulation of neuron differentiation IEA endocrine pancreas development ISS positive regulation of immunoglobulin secretion IDA response to peptidoglycan IEP negative regulation of protein kinase activity IEA positive regulation of MAPKKK cascade IDA interleukin-6 receptor binding NAS cytokine activity IDA growth factor activity IDA Interleukin-6; IL-6; B-cell stimulatory factor 2; BSF-2; CTL differentiation factor; CDF; Hybridoma growth factor; Interferon beta-2; IFN-beta-2; Precursor 11001912 11355017 12768442 1291290 15489334 1883960 2037043 2472117 2610854 2789513 3023045 3266463 3279116 3320204 3491322 3500852 3538015 3758081 7851440 8555185 9118960 9159484 9769329 NA IL6 -1 Interleukin-6 IL-6 B-cell stimulatory factor 2 BSF-2 CTL differentiation factor CDF Hybridoma growth factor Interferon beta-2 IFN-beta-2 Precursor gene 1405 3.04127469753928E-4 ADAM28 D - Genome Maintenance plasma membrane IEA extracellular region IEA integral to membrane IEA proteolysis IEA spermatogenesis TAS zinc ion binding IEA metalloendopeptidase activity IEA metallopeptidase activity IDA Disintegrin and metalloproteinase domain-containing protein 28; ADAM 28; 3.4.24.-; Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II; eMDC II; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L; MDC-L; Precursor 10506182 10587367 15489334 16421571 21618342 NA ADA28 1 Disintegrin and metalloproteinase domain-containing protein 28 ADAM 28 3.4.24.- Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II eMDC II Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L MDC-L Precursor gene 1291 0.0134562520322556 N - Not Matched integral to membrane IEA Transmembrane protein 100 14702039 15489334 NA TM100 -1 Transmembrane protein 100 gene 1291 0.348990914656669 T - Transcription axon IEA presynaptic membrane ISS perinuclear region IDA Golgi apparatus ISS plasma membrane IDA endoplasmic reticulum ISS mitochondrial matrix ISS nucleus IDA dendrite IEA cytosol IDA blood coagulation TAS negative regulation of cAMP biosynthetic process ISS cAMP-mediated signaling IMP positive regulation of inflammatory response ISS protein targeting to mitochondrion ISS monocyte differentiation IEP cGMP catabolic process IDA negative regulation of transcription from RNA polymerase II promoter IDA cGMP-mediated signaling IMP positive regulation of vascular permeability IMP negative regulation of vascular permeability IMP cAMP catabolic process IDA calcium channel activity TAS cAMP binding IMP cGMP binding IDA cGMP-stimulated cyclic-nucleotide phosphodiesterase activity IDA drug binding IDA metal ion binding IEA cGMP-dependent 3',5'-cyclic phosphodiesterase; 3.1.4.17; Cyclic GMP-stimulated phosphodiesterase; CGS-PDE; cGSPDE 15938621 16554811 19369195 19632989 19828435 20213681 9210593 NA PDE2A -1 cGMP-dependent 3',5'-cyclic phosphodiesterase 3.1.4.17 Cyclic GMP-stimulated phosphodiesterase CGS-PDE cGSPDE gene 1505 4.69960616844173E-4 VDR T - Transcription nucleoplasm TAS cell morphogenesis IMP decidualization IEP transcription initiation from RNA polymerase II promoter TAS positive regulation of keratinocyte differentiation IMP positive regulation of transcription from RNA polymerase II promoter IMP negative regulation of transcription from RNA polymerase II promoter IDA sequence-specific DNA binding IEA steroid hormone receptor activity IEA zinc ion binding IEA DNA binding IDA vitamin D3 receptor activity IDA Vitamin D3 receptor; VDR; 1,25-dihydroxyvitamin D3 receptor; Nuclear receptor subfamily 1 group I member 1 10678179 10866662 11344298 11980721 1324736 14702039 15032981 15055995 15225774 15489334 15728261 16252006 16252240 1652893 16913708 1850412 2177843 2835767 2849209 7828346 8106618 8381803 8392085 8675579 8961271 9005998 9212063 9267036 9632709 NA VDR 1 Vitamin D3 receptor VDR 1,25-dihydroxyvitamin D3 receptor Nuclear receptor subfamily 1 group I member 1 TF 1671 1.0 CTNNB1 D - Genome Maintenance desmosome IBA transcription factor complex IDA Z disc IBA centrosome IDA perinuclear region IDA beta-catenin destruction complex IDA catenin complex IDA synapse IBA microvillus membrane IBA apical part of cell IEA lateral plasma membrane IDA lamellipodium IBA cytosol IDA fascia adherens IBA zonula adherens IBA basolateral plasma membrane IEA spindle pole IEA dendritic shaft IBA internal side of plasma membrane IBA cell-substrate adherens junction IDA cell cortex IDA ureteric bud branching IBA bone resorption IEA thymus development IBA oocyte development IBA endodermal cell fate commitment IBA hair follicle morphogenesis IBA male genitalia development IBA cell-cell adhesion IMP embryonic axis specification IBA regulation of T cell proliferation IBA myoblast differentiation IEA positive regulation of I-kappaB kinase/NF-kappaB cascade IBA response to estradiol stimulus IDA positive regulation of fibroblast growth factor receptor signaling pathway IBA cell fate specification IEA synaptic vesicle transport IBA negative regulation of transcription from RNA polymerase II promoter IBA neural plate development IEA embryonic development (sensu Mammalia) IEA gastrulation (sensu Deuterostomia) IBA liver development IBA regulation of centriole-centriole cohesion IDA positive regulation of muscle cell differentiation TAS synapse organization and biogenesis IBA skin development IEA tongue morphogenesis IBA positive regulation of endothelial cell differentiation IEA embryonic digit morphogenesis IEA response to cadmium ion IEA smooth muscle cell differentiation IBA hair cell differentiation TAS negative regulation of cell proliferation IDA genitalia morphogenesis IEA regulation of fibroblast proliferation TAS proximal/distal pattern formation IBA epithelial to mesenchymal transition TAS protein heterooligomerization IEA cell structure disassembly during apoptosis TAS dorsal/ventral axis specification IBA Schwann cell proliferation IBA lens morphogenesis (sensu Vertebrata) IEA anterior/posterior axis specification IEA positive regulation of transcription from RNA polymerase II promoter IDA odontogenesis (sensu Vertebrata) IBA regulation of myelination IEA cell maturation IEA negative regulation of chondrocyte differentiation IBA cytoskeletal anchoring IBA central nervous system vasculogenesis IBA patterning of blood vessels IC positive regulation of apoptosis IDA embryonic heart tube development IEA response to drug IEP osteoclast differentiation IEA regulation of angiogenesis TAS positive regulation of neuroblast proliferation IEA negative regulation of osteoclast differentiation IBA positive regulation of mesenchymal cell proliferation IEA regulation of smooth muscle cell proliferation IMP ectoderm development IBA transcription, DNA-dependent IEA positive regulation of osteoblast differentiation IBA cell-matrix adhesion IBA pancreas development IBA midgut development IEA glial cell fate determination IBA negative regulation of oligodendrocyte differentiation IEA embryonic foregut morphogenesis IBA embryonic hindlimb morphogenesis IEA determination of dorsoventral asymmetry IBA forebrain development IEA embryonic forelimb morphogenesis IEA positive regulation of MAPKKK cascade IBA neuron migration IEA hindbrain development IBA androgen receptor signaling pathway NAS transcription factor activity IEA double-stranded DNA binding IEA protein kinase binding IBA structural molecule activity IBA chromatin binding IEA transcription coactivator activity IMP androgen receptor binding NAS signal transducer activity NAS transcription factor binding TAS Catenin beta-1; Beta-catenin 10029085 10187801 10192393 10391090 10398436 10435629 10655994 10666372 10679188 10966653 11136974 11279024 11389839 11389840 11464291 11590244 11703283 11713475 11713476 11751639 11834740 12019147 12027456 12051714 12077367 12297051 12370829 12408824 12420223 12501215 12640114 12830000 14595118 14702039 15489334 16641997 16858403 17009320 17047063 17081983 17289029 17524503 18077326 18086858 18220336 18378692 18669648 18819930 18957423 19690332 19693690 19816403 19996314 20026641 20068231 20164195 20307497 21132015 21247902 21262353 21269460 21406692 22647378 7806582 7982500 9020842 9065402 9927029 NA CTNB1 0 Catenin beta-1 Beta-catenin TF 1291 0.00150790326259068 NCKAP5 Nck-associated protein 5; NAP-5; Peripheral clock protein 14702039 15489334 15815621 19690332 9344857 NA NCKP5 -1 Nck-associated protein 5 NAP-5 Peripheral clock protein gene 1291 0.0359059239895385 NACC2 C - Cellular Fate and Organization nuclear body ISS nuclear chromatin IDA positive regulation of cell proliferation ISS negative regulation of cell proliferation IDA DNA damage response, signal transduction resulting in induction of apoptosis IDA protein homooligomerization ISS histone deacetylase activity IDA protein homodimerization activity IDA Nucleus accumbens-associated protein 2; NAC-2; BTB/POZ domain-containing protein 14A 15164053 15489334 NA NACC2 -1 Nucleus accumbens-associated protein 2 NAC-2 BTB/POZ domain-containing protein 14A gene 1291 0.0240272120400372 AKAP12 C - Cellular Fate and Organization cytoplasm IDA plasma membrane IDA cytoskeleton IEA cell cortex IEA G-protein coupled receptor protein signaling pathway TAS positive regulation of cAMP biosynthetic process IMP protein targeting IEA protein kinase A binding TAS A-kinase anchor protein 12; AKAP-12; A-kinase anchor protein 250 kDa; AKAP 250; Gravin; Myasthenia gravis autoantigen 14574404 1522245 15496411 16959974 17081983 17525332 17974005 19369195 20213681 21269460 21406692 9000000 9604001 NA AKA12 -1 A-kinase anchor protein 12 AKAP-12 A-kinase anchor protein 250 kDa AKAP 250 Gravin Myasthenia gravis autoantigen gene 2745 1.0 PBX1 C - Cellular Fate and Organization transcription factor complex IEA cytoplasm IDA nucleus IDA positive regulation of cell proliferation IEA steroid biosynthetic process IEA ureteric bud branching IEA adrenal gland development IEA embryonic skeletal development IEA proximal/distal pattern formation IEA thymus development IEA embryonic limb morphogenesis IEA anterior/posterior pattern formation IEA spleen development IEA negative regulation of transcription factor activity IDA transcription, DNA-dependent IEA regulation of ossification IEA negative regulation of neuron differentiation IEA positive regulation of transcription from RNA polymerase II promoter IEA organ morphogenesis IEA sex differentiation IEA embryonic hemopoiesis IEA sequence-specific DNA binding IEA transcription factor activity NAS DNA binding IDA Pre-B-cell leukemia transcription factor 1; Homeobox protein PBX1; Homeobox protein PRL 10052460 10825160 11267683 12609849 14702039 15489334 16710414 1671560 1682799 19559479 1967983 20553494 21269460 21746878 7910944 8327485 NA PBX1 0 Pre-B-cell leukemia transcription factor 1 Homeobox protein PBX1 Homeobox protein PRL TF 3579 8.75335308225391E-4 F - Protein Fate melanosome IEA coated pit IDA perinuclear region IEA integral to plasma membrane TAS cytoplasmic membrane-bound vesicle IDA extracellular region IDA external side of plasma membrane IEA endosome IDA iron ion homeostasis NAS positive regulation of bone resorption IEA virus-host interaction IEA proteolysis IEA osteoclast differentiation IEA transferrin receptor activity NAS peptidase activity IEA Transferrin receptor protein 1; TR; TfR; TfR1; Trfr; T9; p90; CD71; Transferrin receptor protein 1, serum form; sTfR 10377239 10531064 11702220 11800564 1380674 1421756 1421757 15489334 15592455 16325581 16335952 17081065 17287727 18669648 1871153 19159218 19349973 19690332 20068231 21269460 2229063 2298808 2327986 2507316 3568132 3582362 6090955 6094009 7780197 7864799 8408022 8631371 9358047 9782058 NA TFR1 -1 Transferrin receptor protein 1 TR TfR TfR1 Trfr T9 p90 CD71 Transferrin receptor protein 1, serum form sTfR gene 1291 1.0 NFKB2 C - Cellular Fate and Organization nucleoplasm TAS cytosol TAS Toll signaling pathway TAS activation of NF-kappaB transcription factor TAS extracellular matrix organization and biogenesis IEA follicular dendritic cell differentiation IEA innate immune response TAS MyD88-dependent toll-like receptor signaling pathway TAS positive regulation of interferon type I production TAS spleen development IEA germinal center formation IEA transcription, DNA-dependent IEA transcription factor activity TAS transcription coactivator activity TAS DNA binding IEA Nuclear factor NF-kappa-B p100 subunit; DNA-binding factor KBF2; H2TF1; Lymphocyte translocation chromosome 10 protein; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; Oncogene Lyt-10; Lyt10; Nuclear factor NF-kappa-B p52 subunit 10597218 11239468 11526476 14676825 14702039 15164054 1531086 15489334 16477006 1760839 18669648 1876189 20068231 21269460 7541912 7925301 7949142 7969113 8036016 8152812 8360178 8453667 8887665 9315679 9384586 NA NFKB2 0 Nuclear factor NF-kappa-B p100 subunit DNA-binding factor KBF2 H2TF1 Lymphocyte translocation chromosome 10 protein Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 Oncogene Lyt-10 Lyt10 Nuclear factor NF-kappa-B p52 subunit TF 1936 1.0 C - Cellular Fate and Organization mitochondrion IDA nucleoplasm TAS cytosol TAS negative regulation of cholesterol transport IC T cell receptor signaling pathway TAS nerve growth factor receptor signaling pathway TAS negative regulation of apoptosis TAS transcription from RNA polymerase II promoter TAS membrane protein intracellular domain proteolysis TAS apoptosis IEA negative regulation of cytokine production IEA negative regulation of transcription from RNA polymerase II promoter IMP negative regulation of cellular protein metabolic process IC response to bacterium IEA negative regulation of interleukin-12 biosynthetic process IEA Toll signaling pathway TAS inflammatory response TAS activation of NF-kappaB transcription factor TAS MyD88-dependent toll-like receptor signaling pathway TAS innate immune response TAS positive regulation of transcription from RNA polymerase II promoter IEA positive regulation of interferon type I production TAS positive regulation of transcription, DNA-dependent IDA response to copper ion IEA response to oxidative stress IEA double-stranded DNA binding IEA transcription factor activity TAS Nuclear factor NF-kappa-B p105 subunit; DNA-binding factor KBF1; EBP-1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; Nuclear factor NF-kappa-B p50 subunit 10469655 10970863 11094166 11297557 11327828 11466314 11468175 11526476 11739381 12393603 12471036 12482991 12871932 13679070 14702039 14743216 14769797 15102766 15169888 15485931 15489334 17003112 1740106 17974005 18669648 19690332 1992489 21269460 2203531 2234062 7830764 8087845 8152812 8628291 8710491 8825636 9315679 9529257 9865693 9950430 NA NFKB1 0 Nuclear factor NF-kappa-B p105 subunit DNA-binding factor KBF1 EBP-1 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Nuclear factor NF-kappa-B p50 subunit TF 1291 0.0411817672141367 LPL N - Not Matched extracellular matrix IEA plasma membrane IEA cell surface IEA chylomicron IEA anchored to membrane IEA extracellular space IDA response to drug IEA triacylglycerol biosynthetic process IEA lipoprotein metabolic process TAS fatty acid biosynthetic process IDA triacylglycerol catabolic process IDA phospholipid metabolic process ISS triacylglycerol lipase activity IDA phospholipase activity ISS lipoprotein lipase activity IDA heparin binding IDA triglyceride binding IEA Lipoprotein lipase; LPL; 3.1.1.34; Precursor 10391209 10660334 10787434 11068186 11099402 11134145 11342582 11441134 12204001 12641539 12966036 1371284 1400331 1406652 14702039 1479292 14984478 15185149 1521525 15256764 1537564 15489334 15877202 1598907 1619366 1639392 1674945 1702428 1730727 1752947 17997385 18780401 1907278 1969408 1975597 2010533 2038366 2110364 2121025 2243796 2340307 2701938 3823907 7647785 7806969 7906986 7912254 7999071 8077845 8096693 8135797 8288243 8301230 8308035 8325986 8486765 8728326 8778602 8858123 8872057 8956048 8956052 9279761 9298816 9401010 9498099 9662394 9714430 9719626 NA LIPL -1 Lipoprotein lipase LPL 3.1.1.34 Precursor gene 1291 3.6767342038056E-4 D - Genome Maintenance protein complex IEA nucleus IDA cytosol TAS insulin receptor signaling pathway TAS TOR signaling pathway IDA G1/S transition of mitotic cell cycle IMP positive regulation of progression through mitotic cell cycle IMP negative regulation of protein complex assembly IEA lung development IEA response to ethanol IEA negative regulation of translational initiation IEA translational initiation TAS Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I 12150926 12588975 12665801 12747827 14702039 15489334 16271312 17081983 17368478 17487921 17525332 17631896 18220336 18669648 19690332 20068231 21269460 21406692 7935836 8521827 9465032 9684899 NA 4EBP1 1 Eukaryotic translation initiation factor 4E-binding protein 1 4E-BP1 eIF4E-binding protein 1 Phosphorylated heat- and acid-stable protein regulated by insulin 1 PHAS-I gene 1291 0.00171921799516021 DEPTOR C - Cellular Fate and Organization intracellular IDA negative regulation of TOR signaling pathway IMP negative regulation of cell size IMP regulation of apoptosis IMP negative regulation of protein kinase activity IMP DEP domain-containing mTOR-interacting protein; DEP domain-containing protein 6 11230166 14702039 15489334 16421571 19446321 21269460 NA DPTOR 1 DEP domain-containing mTOR-interacting protein DEP domain-containing protein 6 gene 2228 2.1413867831316E-5 Coiled-coil domain-containing protein 141 14702039 15489334 15815621 NA CC141 -1 Coiled-coil domain-containing protein 141 gene 1291 0.0359059239895385 RNH1 N - Not Matched cytoplasm IDA angiogenin-PRI complex IPI regulation of angiogenesis IDA mRNA catabolic process NAS ribonuclease inhibitor activity IDA Ribonuclease inhibitor; Placental ribonuclease inhibitor; Placental RNase inhibitor; Ribonuclease/angiogenin inhibitor 1; RAI 10413501 12578357 14515218 15489334 15755456 1633192 17292889 17350650 17974005 18669648 19690332 20068231 21269460 3219362 3243277 8037455 9050852 9311977 NA RINI -1 Ribonuclease inhibitor Placental ribonuclease inhibitor Placental RNase inhibitor Ribonuclease/angiogenin inhibitor 1 RAI gene 1595 5.95130677841297E-6 B3GNT1 F - Protein Fate integral to Golgi membrane NAS keratan sulfate biosynthetic process TAS poly-N-acetyllactosamine biosynthetic process IDA protein amino acid glycosylation IEA N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity IDA N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase; 2.4.1.149; I-beta-1,3-N-acetylglucosaminyltransferase; iGnT; Poly-N-acetyllactosamine extension enzyme; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 15489334 9405606 NA B3GN1 -1 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2.4.1.149 I-beta-1,3-N-acetylglucosaminyltransferase iGnT Poly-N-acetyllactosamine extension enzyme UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 gene 1291 0.00401808768260578 CSNK2A1 D - Genome Maintenance plasma membrane TAS NuRD complex IDA Sin3 complex IDA cytosol TAS signal transduction TAS regulation of transcription, DNA-dependent IEA cell cycle IEA protein amino acid autophosphorylation IEA axon guidance TAS positive regulation of Wnt receptor signaling pathway IMP Wnt receptor signaling pathway IEA negative regulation of caspase activity IMP transcription, DNA-dependent IEA protein phosphatase regulator activity IEA protein serine/threonine kinase activity IDA Hsp90 protein binding TAS ATP binding IEA Casein kinase II subunit alpha; CK II alpha; 2.7.11.1 11092945 11239457 11574463 11704824 11780052 12393879 12631575 12860116 14646071 14702039 15489334 15684395 16193064 19054851 19188443 19369195 19387549 19387550 19387551 19387552 19387553 19608861 19923321 21269460 2174700 2752008 7592773 8420794 NA CSK21 1 Casein kinase II subunit alpha CK II alpha 2.7.11.1 gene 1291 0.193676256758731 IGF2BP3 P - Translation nucleus IEA cytosol TAS negative regulation of protein biosynthetic process ISS regulation of cytokine biosynthetic process IC translation TAS anatomical structure morphogenesis TAS mRNA 5'-UTR binding IDA nucleotide binding IEA mRNA 3'-UTR binding IDA translation regulator activity ISS Insulin-like growth factor 2 mRNA-binding protein 3; IGF2 mRNA-binding protein 3; IMP-3; IGF-II mRNA-binding protein 3; KH domain-containing protein overexpressed in cancer; hKOC; VICKZ family member 3 10525192 11465943 12161597 12853948 12921532 15489334 15601260 15644775 16049158 16541107 16814207 17192788 17289661 17974005 18669648 19690332 20080952 21269460 21406692 9178771 9891060 NA IF2B3 1 Insulin-like growth factor 2 mRNA-binding protein 3 IGF2 mRNA-binding protein 3 IMP-3 IGF-II mRNA-binding protein 3 KH domain-containing protein overexpressed in cancer hKOC VICKZ family member 3 gene 1291 0.0517126829303475 EPCAM C - Cellular Fate and Organization basolateral plasma membrane IDA apical plasma membrane IDA cell surface IEA tight junction IDA integral to membrane IEA lateral plasma membrane IDA ureteric bud development IEA positive regulation of cell proliferation IDA Epithelial cell adhesion molecule; Ep-CAM; Adenocarcinoma-associated antigen; Cell surface glycoprotein Trop-1; Epithelial cell surface antigen; Epithelial glycoprotein; EGP; Epithelial glycoprotein 314; EGP314; hEGP314; KS 1/4 antigen; KSA; Major gastrointestinal tumor-associated protein GA733-2; Tumor-associated calcium signal transducer 1; CD326; Precursor 11080501 15195135 15489334 15815621 15922867 16054130 18508581 18572020 19098912 19159218 19785009 20064925 2108441 21269460 2333300 2463074 2469722 2911574 7693697 8382772 NA EPCAM 1 Epithelial cell adhesion molecule Ep-CAM Adenocarcinoma-associated antigen Cell surface glycoprotein Trop-1 Epithelial cell surface antigen Epithelial glycoprotein EGP Epithelial glycoprotein 314 EGP314 hEGP314 KS 1/4 antigen KSA Major gastrointestinal tumor-associated protein GA733-2 Tumor-associated calcium signal transducer 1 CD326 Precursor gene 1291 0.0586146050434715 PTPRM C - Cellular Fate and Organization perinuclear region IDA cell-cell adherens junction IDA integral to plasma membrane NAS lamellipodium IDA retinal ganglion cell axon guidance IDA negative regulation of endothelial cell proliferation IMP response to drug IDA positive regulation of vasodilation IEA negative regulation of angiogenesis IMP homophilic cell adhesion IDA cadherin binding IDA transmembrane receptor protein tyrosine phosphatase activity IDA Receptor-type tyrosine-protein phosphatase mu; Protein-tyrosine phosphatase mu; R-PTP-mu; 3.1.3.48; Precursor 16177791 16335952 16456543 1655529 18669648 9346878 NA PTPRM -1 Receptor-type tyrosine-protein phosphatase mu Protein-tyrosine phosphatase mu R-PTP-mu 3.1.3.48 Precursor gene 1291 0.0461415698267577 A - Transport and Sensing endocytic vesicle membrane TAS plasma membrane TAS cytoskeleton IEA regulation of nitric-oxide synthase activity TAS nitric oxide metabolic process TAS endocytosis IEA Nostrin; BM247 homolog; Nitric oxide synthase traffic inducer; Nitric oxide synthase trafficker; eNOS-trafficking inducer 11489260 12446846 14702039 15489334 15815621 15847871 16234328 16376344 16807357 NA NOSTN -1 Nostrin BM247 homolog Nitric oxide synthase traffic inducer Nitric oxide synthase trafficker eNOS-trafficking inducer gene 1291 0.00691815401314746 PID1 C - Cellular Fate and Organization mitochondrion IDA nucleus IDA energy reserve metabolic process IC positive regulation of transcription from RNA polymerase II promoter IMP negative regulation of insulin receptor signaling pathway IDA regulation of mitochondrial membrane potential ISS negative regulation of protein amino acid phosphorylation IDA PTB-containing, cubilin and LRP1-interacting protein; P-CLI1; Phosphotyrosine interaction domain-containing protein 1; Protein NYGGF4 14702039 15221005 15489334 16815647 17124247 NA PCLI1 -1 PTB-containing, cubilin and LRP1-interacting protein P-CLI1 Phosphotyrosine interaction domain-containing protein 1 Protein NYGGF4 gene 1291 0.00616644798288088 PTPRF C - Cellular Fate and Organization integral to plasma membrane TAS transmembrane receptor protein tyrosine phosphatase signaling pathway TAS cell adhesion TAS transmembrane receptor protein tyrosine phosphatase activity TAS heparin binding IEA Receptor-type tyrosine-protein phosphatase F; 3.1.3.48; Leukocyte common antigen related; LAR; Precursor 10338209 15489334 15491607 16335952 16710414 1695146 19349973 21269460 2554325 2972792 8995282 9624153 NA PTPRF 1 Receptor-type tyrosine-protein phosphatase F 3.1.3.48 Leukocyte common antigen related LAR Precursor gene 1599 0.00133051464757286 MCAM C - Cellular Fate and Organization integral to membrane IEA external side of plasma membrane IDA cell adhesion TAS Cell surface glycoprotein MUC18; Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen; CD146; Precursor 11036077 11709656 14702039 15489334 18669648 19159218 20068231 21269460 2602381 8162602 8292890 8378324 8573133 NA MUC18 -1 Cell surface glycoprotein MUC18 Cell surface glycoprotein P1H12 Melanoma cell adhesion molecule Melanoma-associated antigen A32 Melanoma-associated antigen MUC18 S-endo 1 endothelial-associated antigen CD146 Precursor gene 2207 4.45149968674447E-6 C - Cellular Fate and Organization integral to plasma membrane TAS neuron differentiation ISS positive regulation of dendrite morphogenesis ISS transmembrane receptor protein tyrosine phosphatase signaling pathway TAS heterophilic cell adhesion ISS transmembrane receptor protein tyrosine phosphatase activity TAS receptor binding ISS cell adhesion molecule binding ISS Receptor-type tyrosine-protein phosphatase delta; Protein-tyrosine phosphatase delta; R-PTP-delta; 3.1.3.48; Precursor 14759258 15164053 15489334 16959974 2170109 7896816 9624153 NA PTPRD -1 Receptor-type tyrosine-protein phosphatase delta Protein-tyrosine phosphatase delta R-PTP-delta 3.1.3.48 Precursor gene 1643 3.64200105952225E-5 CDC34 D - Genome Maintenance cytoplasm IDA nucleus NAS G1/S transition of mitotic cell cycle NAS DNA replication initiation NAS proteasomal ubiquitin-dependent protein catabolic process IDA ubiquitin-protein ligase activity IDA ATP binding IEA Ubiquitin-conjugating enzyme E2 R1; 6.3.2.19; Ubiquitin-conjugating enzyme E2-32 kDa complementing; Ubiquitin-conjugating enzyme E2-CDC34; Ubiquitin-protein ligase R1 10329681 10373550 10769200 10871850 10918611 11447293 11546811 11675391 11805320 12037680 12060736 14702039 15489334 15652359 17461777 17698585 18851830 19112177 19126550 19945379 20061386 20347421 21269460 8248134 NA UB2R1 1 Ubiquitin-conjugating enzyme E2 R1 6.3.2.19 Ubiquitin-conjugating enzyme E2-32 kDa complementing Ubiquitin-conjugating enzyme E2-CDC34 Ubiquitin-protein ligase R1 gene 1291 0.00298781153961145 ERO1L C - Cellular Fate and Organization membrane TAS endoplasmic reticulum membrane IEA endoplasmic reticulum lumen TAS response to temperature stimulus TAS release of sequestered calcium ion into cytosol ISS brown fat cell differentiation IEA chaperone cofactor-dependent protein folding IDA protein modification TAS unfolded protein response IEA FAD binding IEA oxidoreductase activity IDA oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor IEA ERO1-like protein alpha; ERO1-L; ERO1-L-alpha; 1.8.4.-; Endoplasmic oxidoreductin-1-like protein; Oxidoreductin-1-L-alpha; Precursor 10671517 10818100 10970843 11707280 11707400 11847130 12403808 12508121 12752442 12975309 14517240 14702039 15136577 15161913 15475357 15489334 18833192 18971943 19159218 20068231 20834232 21269460 NA ERO1A 1 ERO1-like protein alpha ERO1-L ERO1-L-alpha 1.8.4.- Endoplasmic oxidoreductin-1-like protein Oxidoreductin-1-L-alpha Precursor gene 1291 0.0379207494027276 PTPRB C - Cellular Fate and Organization integral to plasma membrane TAS angiogenesis IEA transmembrane receptor protein tyrosine phosphatase activity TAS Receptor-type tyrosine-protein phosphatase beta; Protein-tyrosine phosphatase beta; R-PTP-beta; 3.1.3.48; Vascular endothelial protein tyrosine phosphatase; VE-PTP; Precursor 15144186 15489334 16541075 16759857 17139078 17974005 19116766 19136612 19167335 19451274 2170109 NA PTPRB -1 Receptor-type tyrosine-protein phosphatase beta Protein-tyrosine phosphatase beta R-PTP-beta 3.1.3.48 Vascular endothelial protein tyrosine phosphatase VE-PTP Precursor gene 1291 0.00978843737578061 KAT2B D - Genome Maintenance actomyosin IEA PCAF complex NAS chromatin remodeling complex IDA kinetochore IEA Ada2/Gcn5/Ada3 transcription activator complex IDA A band IEA I band IEA transcription initiation from RNA polymerase II promoter TAS negative regulation of cell proliferation IDA Notch signaling pathway TAS virus-host interaction IEA negative regulation of cyclin-dependent protein kinase activity IEA positive regulation of transcription from RNA polymerase II promoter IDA transcription initiation from RNA polymerase I promoter TAS chromatin remodeling NAS cell cycle arrest TAS N-terminal peptidyl-lysine acetylation IDA lysine N-acetyltransferase activity ISS protein kinase binding ISS transcription coactivator activity IDA cyclin-dependent protein kinase inhibitor activity ISS histone acetyltransferase activity IEA Histone acetyltransferase KAT2B; 2.3.1.48; Histone acetyltransferase PCAF; Histone acetylase PCAF; Lysine acetyltransferase 2B; P300/CBP-associated factor; P/CAF 10365964 10675335 10766811 11568182 11931765 12486002 14767476 15273251 15489334 16887930 17226766 17707232 22464331 8684459 8945521 9296499 9346901 9707565 NA KAT2B -1 Histone acetyltransferase KAT2B 2.3.1.48 Histone acetyltransferase PCAF Histone acetylase PCAF Lysine acetyltransferase 2B P300/CBP-associated factor P/CAF gene 1291 0.00847698171552547 MYLK C - Cellular Fate and Organization stress fiber IDA plasma membrane IDA cleavage furrow IDA lamellipodium IDA cytosol TAS positive regulation of cell migration IDA positive regulation of calcium ion transport IDA bleb formation IMP myosin light chain kinase activity IDA ATP binding IEA metal ion binding IEA Myosin light chain kinase, smooth muscle; MLCK; smMLCK; 2.7.11.18; Kinase-related protein; KRP; Telokin; Myosin light chain kinase, smooth muscle, deglutamylated form 10198165 10536370 11113114 11976941 12408982 14702039 14741352 15020676 15489334 15507455 15825080 16284075 16641997 16723733 16835238 17344846 18088087 18318008 18462678 18587400 18710790 19011151 19429448 19826488 20053363 20139351 20181817 20375339 20453870 20861316 21055718 21918590 8575746 9160829 NA MYLK -1 Myosin light chain kinase, smooth muscle MLCK smMLCK 2.7.11.18 Kinase-related protein KRP Telokin Myosin light chain kinase, smooth muscle, deglutamylated form gene 1291 0.14228945765784 SGPL1 D - Genome Maintenance integral to endoplasmic reticulum membrane NAS hemopoiesis IEA kidney development IEA ceramide metabolic process IDA androgen metabolic process IEA sphingolipid biosynthetic process TAS sphingolipid catabolic process NAS luteinization IEA skeletal morphogenesis IEA apoptosis IDA spermatogenesis IEA post-embryonic development IEA estrogen metabolic process IEA regulation of body size IEA palate development IEA platelet-derived growth factor receptor signaling pathway IEA phospholipid metabolic process TAS carboxylic acid metabolic process IEA vasculogenesis IEA sphinganine-1-phosphate aldolase activity NAS pyridoxal phosphate binding IEA carboxy-lyase activity IEA Sphingosine-1-phosphate lyase 1; S1PL; SP-lyase 1; SPL 1; hSPL; 4.1.2.27; Sphingosine-1-phosphate aldolase 10574462 11018465 14570870 14702039 15489334 16777052 18691976 19608861 19690332 20068231 21269460 NA SGPL1 1 Sphingosine-1-phosphate lyase 1 S1PL SP-lyase 1 SPL 1 hSPL 4.1.2.27 Sphingosine-1-phosphate aldolase gene 1291 0.0313018543002082 INTS8 T - Transcription integrator complex IDA snRNA processing IDA Integrator complex subunit 8; Int8; Protein kaonashi-1 14702039 15489334 16239144 17081983 17974005 NA INT8 1 Integrator complex subunit 8 Int8 Protein kaonashi-1 gene 1291 0.0381457414750155 INTS7 T - Transcription chromosome IDA integrator complex IDA DNA damage checkpoint IMP snRNA processing IDA Integrator complex subunit 7; Int7 11230166 14702039 15489334 16239144 16710414 17974005 18691976 20068231 21269460 21659603 NA INT7 1 Integrator complex subunit 7 Int7 gene 1291 0.00121217492072079 AACS C - Cellular Fate and Organization cytosol IEA liver development IEA response to starvation IEA white fat cell differentiation IEA response to nutrient IEA response to drug IEA response to ethanol IEA fatty acid metabolic process IEA positive regulation of insulin secretion IEA ATP binding IEA butyrate-CoA ligase activity IEA acetoacetate-CoA ligase activity IEA Acetoacetyl-CoA synthetase; 6.2.1.16; Acyl-CoA synthetase family member 1; Protein sur-5 homolog 12623130 14702039 15489334 17762044 17974005 21269460 9671465 NA AACS 1 Acetoacetyl-CoA synthetase 6.2.1.16 Acyl-CoA synthetase family member 1 Protein sur-5 homolog gene 1291 0.265873318267263 N - Not Matched endoplasmic reticulum membrane TAS xenobiotic metabolic process TAS glutathione metabolic process IDA glutathione transferase activity IDA Glutathione S-transferase Mu 5; 2.5.1.18; GST class-mu 5; GSTM5-5 10587441 14702039 15489334 8473333 NA GSTM5 -1 Glutathione S-transferase Mu 5 2.5.1.18 GST class-mu 5 GSTM5-5 gene 1291 0.325044433804753 T - Transcription cytoplasm IEA nucleus IEA extracellular space IDA negative regulation of transcription from RNA polymerase II promoter IEA transcription, DNA-dependent IEA transcription corepressor activity ISS zinc ion binding IEA LIM and cysteine-rich domains protein 1; Dyxin 10662546 14702039 15489334 16199866 20026769 NA LMCD1 -1 LIM and cysteine-rich domains protein 1 Dyxin gene 1291 0.0618335061845588 CYLD D - Genome Maintenance perinuclear region IEA microtubule IEA cytosol IDA extrinsic to internal side of plasma membrane IDA ubiquitin-dependent protein catabolic process IEA regulation of progression through mitotic cell cycle IMP cell cycle IEA negative regulation of NF-kappaB import into nucleus IDA innate immune response TAS inhibition of NF-kappaB transcription factor IDA induction of apoptosis IDA Wnt receptor signaling pathway IEA negative regulation of interferon type I production TAS ubiquitin-specific protease activity IDA zinc ion binding IDA ubiquitin thiolesterase activity IEA Ubiquitin carboxyl-terminal hydrolase CYLD; 3.4.19.12; Deubiquitinating enzyme CYLD; Ubiquitin thioesterase CYLD; Ubiquitin-specific-processing protease CYLD 10048485 10835629 11042152 12168954 12190880 12917689 12917690 12917691 12950348 14632188 14676304 15341735 15489334 15854031 15870263 16307661 16922728 17495026 18222923 18313383 18636086 18669648 19893491 20194890 20227366 NA CYLD -1 Ubiquitin carboxyl-terminal hydrolase CYLD 3.4.19.12 Deubiquitinating enzyme CYLD Ubiquitin thioesterase CYLD Ubiquitin-specific-processing protease CYLD gene 1291 1.57388085976951E-4 MARC2 N - Not Matched mitochondrion ISS mitochondrial inner membrane IEA mitochondrial outer membrane IEA peroxisome IEA detoxification of nitrogen compound NAS nitrate metabolic process IDA molybdopterin cofactor binding IDA nitrate reductase activity IDA pyridoxal phosphate binding IEA molybdenum ion binding IDA MOSC domain-containing protein 2, mitochondrial; 1.-.-.-; Mitochondrial amidoxime reducing component 2; mARC2; Moco sulfurase C-terminal domain-containing protein 2; Molybdenum cofactor sulfurase C-terminal domain-containing protein 2; Precursor 11230166 14702039 15489334 16710414 17974005 21029045 21269460 NA MOSC2 -1 MOSC domain-containing protein 2, mitochondrial 1.-.-.- Mitochondrial amidoxime reducing component 2 mARC2 Moco sulfurase C-terminal domain-containing protein 2 Molybdenum cofactor sulfurase C-terminal domain-containing protein 2 Precursor gene 9134 0.0445476935312808 T - Transcription nucleus IEA hemostasis TAS circulation IEA organ morphogenesis TAS transcription, DNA-dependent IEA transcription factor activity TAS DNA binding TAS Friend leukemia integration 1 transcription factor; Proto-oncogene Fli-1; Transcription factor ERGB 1394211 1445800 14702039 1522903 15489334 16554811 1765382 19690332 7542907 7773776 8439553 9751743 NA FLI1 -1 Friend leukemia integration 1 transcription factor Proto-oncogene Fli-1 Transcription factor ERGB TF 1291 0.0517126829303475 F - Protein Fate cell junction IEA lamellipodium membrane IEA integral to membrane NAS extracellular space IDA lamellipodium IDA endothelial cell migration IDA proteolysis IEA regulation of fibrinolysis IC serine-type endopeptidase activity IEA serine-type peptidase activity IDA metalloendopeptidase activity TAS dipeptidyl-peptidase activity NAS protein homodimerization activity NAS Seprase; 3.4.21.-; 170 kDa melanoma membrane-bound gelatinase; Fibroblast activation protein alpha; Integral membrane serine protease 10644713 15489334 15809306 15815621 16335952 16651416 7519584 7911242 9065413 9247085 NA SEPR 1 Seprase 3.4.21.- 170 kDa melanoma membrane-bound gelatinase Fibroblast activation protein alpha Integral membrane serine protease gene 1291 0.0517126829303475 SEC24D F - Protein Fate perinuclear region IEA COPII vesicle coat NAS Golgi membrane IEA endoplasmic reticulum membrane TAS cytosol TAS antigen processing and presentation of peptide antigen via MHC class I TAS antigen processing and presentation of exogenous peptide antigen via MHC class II TAS COPII coating of Golgi vesicle TAS intracellular protein transport IEA protein amino acid N-linked glycosylation via asparagine TAS zinc ion binding IEA Protein transport protein Sec24D; SEC24-related protein D 10329445 15489334 20427317 21269460 9872452 NA SC24D 1 Protein transport protein Sec24D SEC24-related protein D gene 1291 0.192219042941373 N - Not Matched mitochondrion IBA Golgi trans face IEA extracellular matrix IEA nucleus IBA extracellular space IDA cytosol IBA response to hypoxia IEA removal of superoxide radicals IBA response to copper ion IEA copper ion binding IBA zinc ion binding IBA heparin binding IEA superoxide dismutase activity IBA Extracellular superoxide dismutase [Cu-Zn]; EC-SOD; 1.15.1.1; Precursor 1505778 15489334 16087389 16335952 19159218 19289127 3476950 7662997 7959763 8034674 8546689 8864862 NA SODE -1 Extracellular superoxide dismutase [Cu-Zn] EC-SOD 1.15.1.1 Precursor gene 1291 0.0206031870155919 F - Protein Fate perinuclear region IEA COPII vesicle coat NAS Golgi membrane IEA endoplasmic reticulum membrane TAS cytosol TAS antigen processing and presentation of peptide antigen via MHC class I TAS antigen processing and presentation of exogenous peptide antigen via MHC class II TAS COPII coating of Golgi vesicle TAS intracellular protein transport IEA protein amino acid N-linked glycosylation via asparagine TAS zinc ion binding IEA Protein transport protein Sec24A; SEC24-related protein A 10075675 15489334 20427317 21269460 NA SC24A 1 Protein transport protein Sec24A SEC24-related protein A gene 1333 0.114556492608207 EHD1 C - Cellular Fate and Organization lipid particle ISS perinuclear region IEA plasma membrane IEA early endosome membrane IDA endocytic vesicle IEA platelet dense tubular network membrane ISS GTP catabolic process IEA cholesterol homeostasis ISS blood coagulation TAS endocytic recycling IMP protein homooligomerization IPI intracellular protein transport IMP endocytosis IEA calcium ion binding IEA GTPase activity IEA GTP binding IEA ATP binding IEA EH domain-containing protein 1; PAST homolog 1; hPAST1; Testilin 10395801 12665801 15020713 15489334 15592455 17233914 17899392 18331452 18669648 18691976 19690332 20068231 21269460 21406692 9253601 NA EHD1 -1 EH domain-containing protein 1 PAST homolog 1 hPAST1 Testilin gene 1523 0.00964032494266694 C - Cellular Fate and Organization plasma membrane IEA endoplasmic reticulum IEA nucleus IEA polysome IDA cytosol IDA glycogen metabolic process NAS behavior IEA nervous system development IEA protein serine/threonine phosphatase activity IDA protein tyrosine/serine/threonine phosphatase activity IEA protein tyrosine phosphatase activity IDA Laforin; 3.1.3.16; 3.1.3.48; Lafora PTPase; LAFPTPase 14574404 22036712 11001928 11175283 11220751 11735300 11739371 11883934 12019207 12560877 12782127 12915448 14532330 14574404 14702039 14706656 14722920 15009235 15489334 15930137 16021330 17908927 18070875 18311786 18617530 19036738 21728993 22036712 9771710 9931343 NA EPM2A -1 Laforin 3.1.3.16 3.1.3.48 Lafora PTPase LAFPTPase gene 1291 0.152810214692298 A - Transport and Sensing integral to plasma membrane TAS gap junction TAS connexon complex IEA blood vessel development IEA transport TAS intercellular junction assembly TAS cell-cell signaling IEA calcium ion transport IEA response to pain IEA Gap junction alpha-4 protein; Connexin-37; Cx37 10447790 10728596 14702039 15489334 16710414 7680674 8761439 NA CXA4 -1 Gap junction alpha-4 protein Connexin-37 Cx37 gene 1291 0.020077089894473 GJA1 C - Cellular Fate and Organization fascia adherens IEA integral to plasma membrane TAS multivesicular body IEA Golgi-associated vesicle membrane TAS endoplasmic reticulum membrane TAS mitochondrial outer membrane IEA connexon complex TAS lipid raft ISS lysosome IEA early endosome IEA positive regulation of protein catabolic process IEA negative regulation of cell proliferation IEA apoptosis IEA response to peptide hormone stimulus IEA vascular transport IEA gap junction assembly TAS protein oligomerization IEA heart development TAS muscle contraction TAS neurite morphogenesis IEA regulation of calcium ion transport IEA ATP transport IEA positive regulation of I-kappaB kinase/NF-kappaB cascade IMP membrane organization and biogenesis TAS response to pH IEA gap-junction forming channel activity IDA ion transporter activity TAS signal transducer activity IMP Gap junction alpha-1 protein; Connexin-43; Cx43; Gap junction 43 kDa heart protein 10581143 10764404 11470490 11741837 12270943 12457340 14574404 14702039 14702389 14729836 14974090 15108203 15489334 15605363 15637728 15757815 15978203 16112082 16219735 16222672 16378922 1646158 16709485 16813608 16816024 1696265 17509830 18161618 19338053 21406692 22411987 7715640 8873667 9155619 9430691 9443444 NA CXA1 -1 Gap junction alpha-1 protein Connexin-43 Cx43 Gap junction 43 kDa heart protein gene 1291 0.0125304158240803 C - Cellular Fate and Organization plasma membrane TAS intercellular junction IEA endoplasmic reticulum lumen TAS collagen type XIII TAS integral to membrane IEA endochondral ossification ISS cell-cell adhesion IEP cell-matrix adhesion IPI extracellular matrix organization and biogenesis TAS cell differentiation IEA morphogenesis of a branching structure ISS heparin binding IDA extracellular matrix structural constituent NAS Collagen alpha-1(XIII) chain; COLXIIIA1 10865988 11013208 11956183 1447209 1447210 15164054 15489334 1698771 2459707 3547403 8246446 NA CODA1 -1 Collagen alpha-1(XIII) chain COLXIIIA1 gene 1291 0.122062164231375 ARID5A T - Transcription transcription factor complex IEA nucleolus IDA chondrocyte differentiation IEA positive regulation of transcription from RNA polymerase II promoter IEA positive regulation of histone acetylation IEA negative regulation of transcription, DNA-dependent TAS transcription, DNA-dependent IEA chromatin binding IEA DNA binding TAS AT-rich interactive domain-containing protein 5A; ARID domain-containing protein 5A; Modulator recognition factor 1; MRF-1 8649988 NA ARI5A -1 AT-rich interactive domain-containing protein 5A ARID domain-containing protein 5A Modulator recognition factor 1 MRF-1 gene 1291 3.6767342038056E-4 TMEM132A N - Not Matched Golgi membrane IEA endoplasmic reticulum membrane IEA integral to membrane IEA Transmembrane protein 132A; HSPA5-binding protein 1; Precursor 10997877 14702039 15489334 17974005 NA T132A 1 Transmembrane protein 132A HSPA5-binding protein 1 Precursor gene 1291 6.86433599827297E-4 SOBP N - Not Matched inner ear morphogenesis IEA sensory perception of sound IEA locomotory behavior IEA SUMO polymer binding IDA metal ion binding IEA Sine oculis-binding protein homolog; Jackson circler protein 1 14574404 14702039 15489334 21035105 23086935 NA SOBP -1 Sine oculis-binding protein homolog Jackson circler protein 1 gene 1291 0.152810214692298 C - Cellular Fate and Organization cytoplasm IEA extracellular region IEA inflammatory response TAS lipoprotein metabolic process IEA positive regulation of I-kappaB kinase/NF-kappaB cascade IMP signal transducer activity IMP lipid transporter activity TAS lipid binding IEA Apolipoprotein L3; Apolipoprotein L-III; ApoL-III; TNF-inducible protein CG12-1; CG12_1 10233894 10591208 11290834 11374903 15461802 15489334 NA APOL3 -1 Apolipoprotein L3 Apolipoprotein L-III ApoL-III TNF-inducible protein CG12-1 CG12_1 gene 1291 3.66743880664044E-4 R - Stress and Defence endoplasmic reticulum membrane TAS cytosol TAS arachidonic acid metabolic process NAS inflammatory response NAS parturition NAS glycerophospholipid catabolic process IDA phospholipid catabolic process IEA glycerophospholipid biosynthetic process TAS phospholipid binding NAS calcium-independent phospholipase A2 activity IDA phospholipase activity IEA Cytosolic phospholipase A2 gamma; cPLA2-gamma; 3.1.1.4; Phospholipase A2 group IVC; Precursor 10085124 14529291 14702039 15057824 15489334 17974005 18088087 9705332 NA PA24C -1 Cytosolic phospholipase A2 gamma cPLA2-gamma 3.1.1.4 Phospholipase A2 group IVC Precursor gene 1463 0.0998405528812485 ENO1 T - Transcription plasma membrane IEA nucleus IC phosphopyruvate hydratase complex IEA M line IEA cytosol TAS negative regulation of cell growth IDA gluconeogenesis TAS negative regulation of transcription from RNA polymerase II promoter TAS response to virus IEP glycolysis TAS transcription, DNA-dependent IEA magnesium ion binding IEA transcription factor activity TAS transcription corepressor activity TAS DNA binding IEA phosphopyruvate hydratase activity TAS Alpha-enolase; 4.2.1.11; 2-phospho-D-glycerate hydro-lyase; C-myc promoter-binding protein; Enolase 1; MBP-1; MPB-1; Non-neural enolase; NNE; Phosphopyruvate hydratase; Plasminogen-binding protein 10082554 10681589 10802057 11134351 11497239 12297304 12666133 1369209 14702039 15489334 15592455 16139798 16548883 16710414 16815975 17974005 18669648 19608861 19690332 2005901 20068231 21269460 21908771 2373081 3529090 7787969 8824716 9110174 9150948 9308760 9653645 9878089 NA ENOA 1 Alpha-enolase 4.2.1.11 2-phospho-D-glycerate hydro-lyase C-myc promoter-binding protein Enolase 1 MBP-1 MPB-1 Non-neural enolase NNE Phosphopyruvate hydratase Plasminogen-binding protein gene 1300 1.0 SREBF2 T - Transcription ER to Golgi transport vesicle membrane IEA Golgi membrane IEA nucleus IDA lipid metabolic process TAS positive regulation of transcription from RNA polymerase II promoter IDA transcription, DNA-dependent IEA cholesterol metabolic process IEA transcription factor activity IEA Sterol regulatory element-binding protein 2; SREBP-2; Class D basic helix-loop-helix protein 2; bHLHd2; Sterol regulatory element-binding transcription factor 2; Processed sterol regulatory element-binding protein 2 10591208 10805775 14645851 15461802 15489334 16959974 19706601 7903453 8402897 8626610 8643593 9651382 NA SRBP2 0 Sterol regulatory element-binding protein 2 SREBP-2 Class D basic helix-loop-helix protein 2 bHLHd2 Sterol regulatory element-binding transcription factor 2 Processed sterol regulatory element-binding protein 2 TF 1363 9.91614934069764E-7 PLA2G4A C - Cellular Fate and Organization Golgi apparatus IEA mitochondrial inner membrane TAS endoplasmic reticulum membrane TAS cytoplasmic membrane-bound vesicle IEA cytosol NAS icosanoid biosynthetic process IEA platelet activating factor biosynthetic process NAS regulation of cell proliferation IEA platelet activation TAS phosphatidic acid biosynthetic process TAS phospholipid catabolic process IEA icosanoid metabolic process NAS arachidonic acid secretion IEA calcium-dependent phospholipid binding IDA lysophospholipase activity IEA phospholipase A2 activity IDA calcium ion binding IDA Cytosolic phospholipase A2; cPLA2; Phospholipase A2 group IVA; Phospholipase A2; 3.1.1.4; Phosphatidylcholine 2-acylhydrolase; Lysophospholipase; 3.1.1.5 10319815 11416127 15489334 16710414 16959974 16964243 17081983 18088087 18669648 1869522 1904318 20068231 21269460 21406692 8083230 8381049 8619991 8702602 9430701 9468497 9665851 NA PA24A 1 Cytosolic phospholipase A2 cPLA2 Phospholipase A2 group IVA Phospholipase A2 3.1.1.4 Phosphatidylcholine 2-acylhydrolase Lysophospholipase 3.1.1.5 gene 1291 0.0244174348753505 C - Cellular Fate and Organization mitochondrion IDA cellular respiration IMP protein amino acid phosphorylation IEA protein kinase activity IEA FAST kinase domain-containing protein 3 15372022 15489334 16959974 NA FAKD3 1 FAST kinase domain-containing protein 3 gene 1351 1.0 D - Genome Maintenance transcription factor complex IDA cytoplasm IDA positive regulation of cell proliferation IDA positive regulation of cell growth IMP negative regulation of interleukin-5 production IDA somitogenesis IBA negative regulation of interleukin-4 production IDA neural crest cell migration IBA mammary gland development IBA sprouting angiogenesis IBA formation of radial glial scaffolds IBA epithelial to mesenchymal transition ISS embryonic limb morphogenesis IBA radial glial cell differentiation in the forebrain IBA muscle fiber development IBA sensory perception of taste IEA B cell proliferation IBA positive regulation of granulocyte differentiation IDA eye pigmentation IBA regulation of striated muscle development IBA odontogenesis (sensu Vertebrata) IEA palate development ISS neutrophil differentiation IMP regulation of cell-cell adhesion IEA dentate gyrus development IBA negative regulation of cell-cell adhesion IDA patterning of blood vessels IBA anatomical structure regression IEA positive regulation of cell-cell adhesion IDA positive regulation of cell migration IDA forebrain neuron differentiation IBA induction of apoptosis IBA negative regulation of transcription from RNA polymerase II promoter IEA BMP signaling pathway IBA hypothalamus development IBA forebrain neuroblast division IBA osteoblast differentiation IEP negative regulation of striated muscle development IEA negative regulation of DNA binding IDA T-helper 1 cell differentiation ISS negative regulation of interleukin-13 production IDA paraxial mesoderm formation IBA positive regulation of transcription, DNA-dependent IDA tongue development IEA negative regulation of transcription, DNA-dependent IDA beta-catenin binding IDA DNA bending activity ISS RNA polymerase II transcription factor activity, enhancer binding IBA chromatin binding IBA estrogen receptor binding IDA estrogen receptor activity IDA caspase inhibitor activity IMP Lymphoid enhancer-binding factor 1; LEF-1; T cell-specific transcription factor 1-alpha; TCF1-alpha 10756202 11266540 11326276 12192039 12556497 14702039 14759258 15489334 15815621 16959974 19653274 19690332 2010090 9119228 9488439 9751710 NA LEF1 0 Lymphoid enhancer-binding factor 1 LEF-1 T cell-specific transcription factor 1-alpha TCF1-alpha TF 1291 0.0079629809758649 KRT80 N - Not Matched keratin filament IEA structural molecule activity IEA Keratin, type II cytoskeletal 80; Cytokeratin-80; CK-80; Keratin-80; K80; Type-II keratin Kb20 15489334 15737194 17974005 18669648 18691976 21269460 NA K2C80 1 Keratin, type II cytoskeletal 80 Cytokeratin-80 CK-80 Keratin-80 K80 Type-II keratin Kb20 gene 1291 0.00551430130139407 CD302 N - Not Matched microvillus IEA integral to membrane IEA filopodium IDA cell cortex IDA phagocytosis IDA carbohydrate binding IEA CD302 antigen; C-type lectin BIMLEC; C-type lectin domain family 13 member A; DEC205-associated C-type lectin 1; Type I transmembrane C-type lectin receptor DCL-1; CD302; Precursor 12824192 14702039 15489334 15815621 17947679 7584026 NA CD302 -1 CD302 antigen C-type lectin BIMLEC C-type lectin domain family 13 member A DEC205-associated C-type lectin 1 Type I transmembrane C-type lectin receptor DCL-1 CD302 Precursor gene 1291 0.00106232178122635 APEX2 D - Genome Maintenance mitochondrial inner membrane IEA nucleus IEA cell cycle IEA DNA repair IEA DNA recombination IEA DNA-(apurinic or apyrimidinic site) lyase activity IEA exonuclease activity IEA endonuclease activity IEA zinc ion binding IEA DNA binding IEA DNA-(apurinic or apyrimidinic site) lyase 2; 3.1.-.-; 4.2.99.18; AP endonuclease XTH2; APEX nuclease 2; APEX nuclease-like 2; Apurinic-apyrimidinic endonuclease 2; AP endonuclease 2 11376153 15489334 15772651 16687656 18669648 19443450 20843780 NA APEX2 1 DNA-(apurinic or apyrimidinic site) lyase 2 3.1.-.- 4.2.99.18 AP endonuclease XTH2 APEX nuclease 2 APEX nuclease-like 2 Apurinic-apyrimidinic endonuclease 2 AP endonuclease 2 gene 1291 0.0211472487140471 PLEKHO2 N - Not Matched phospholipid binding IEA Pleckstrin homology domain-containing family O member 2; PH domain-containing family O member 2; Pleckstrin homology domain-containing family Q member 1; PH domain-containing family Q member 1 15489334 15498874 16572171 NA PKHO2 -1 Pleckstrin homology domain-containing family O member 2 PH domain-containing family O member 2 Pleckstrin homology domain-containing family Q member 1 PH domain-containing family Q member 1 gene 1578 0.0382437203323004 SYNJ2 C - Cellular Fate and Organization membrane IEA cytosol TAS phosphoinositide phosphorylation IEA phosphatidylinositol biosynthetic process TAS phosphoinositide 5-phosphatase activity IEA nucleotide binding IEA RNA binding IEA Synaptojanin-2; 3.1.3.36; Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2 11084340 11498538 14574404 15489334 19690332 21269460 9205841 NA SYNJ2 1 Synaptojanin-2 3.1.3.36 Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2 gene 2528 0.408965318196766 SUN2 D - Genome Maintenance condensed nuclear chromosome IEA nuclear membrane IDA nuclear inner membrane IEA integral to membrane IEA nuclear chromosome, telomeric region IEA endosome membrane IEA centrosome localization ISS positive regulation of cell migration ISS nuclear migration along microfilament ISS nuclear membrane organization and biogenesis IGI mitotic spindle organization and biogenesis TAS microtubule binding TAS lamin binding IDA SUN domain-containing protein 2; Protein unc-84 homolog B; Rab5-interacting protein; Rab5IP; Sad1/unc-84 protein-like 2 10375507 10591208 10818110 12239280 12393179 12958361 15082709 15461802 15489334 17081983 17132086 17724119 17974005 18396275 18845190 19159218 19690332 21269460 9734811 NA SUN2 -1 SUN domain-containing protein 2 Protein unc-84 homolog B Rab5-interacting protein Rab5IP Sad1/unc-84 protein-like 2 gene 1291 0.00184563327097497 SRGN C - Cellular Fate and Organization zymogen granule IEA Golgi apparatus IDA platelet alpha granule lumen TAS extracellular space IDA mast cell granule ISS protein processing ISS platelet degranulation TAS apoptosis IDA platelet activation TAS negative regulation of bone mineralization IDA negative regulation of cytokine secretion ISS biomineral formation IEA Serglycin; Hematopoietic proteoglycan core protein; Platelet proteoglycan core protein; P.PG; Secretory granule proteoglycan core protein; Precursor 11154222 11911826 12388539 1377686 14702039 15136585 15164054 15489334 16420477 16870619 2180935 2798108 2835370 3214420 3402609 NA SRGN -1 Serglycin Hematopoietic proteoglycan core protein Platelet proteoglycan core protein P.PG Secretory granule proteoglycan core protein Precursor gene 1291 3.6767342038056E-4 PPP1R14B C - Cellular Fate and Organization cytoplasm IEA regulation of phosphorylation IEA protein phosphatase type 1 regulator activity IEA protein phosphatase inhibitor activity IEA Protein phosphatase 1 regulatory subunit 14B; Phospholipase C-beta-3 neighbouring gene protein 15489334 16964243 18669648 19690332 20068231 21269460 8838322 NA PP14B 1 Protein phosphatase 1 regulatory subunit 14B Phospholipase C-beta-3 neighbouring gene protein gene 1291 0.0117302052785924 PPP1R14A C - Cellular Fate and Organization cytoplasm IEA regulation of phosphorylation IEA protein phosphatase inhibitor activity IEA Protein phosphatase 1 regulatory subunit 14A; 17 kDa PKC-potentiated inhibitory protein of PP1; Protein kinase C-potentiated inhibitor protein of 17 kDa; CPI-17 11467857 12974676 15003508 15489334 18088087 20068231 21269460 21406692 NA PP14A -1 Protein phosphatase 1 regulatory subunit 14A 17 kDa PKC-potentiated inhibitory protein of PP1 Protein kinase C-potentiated inhibitor protein of 17 kDa CPI-17 gene 1291 0.0244174348753505 PHLDA2 C - Cellular Fate and Organization cytoplasm IEA membrane IEA apoptosis TAS organ morphogenesis IEA phospholipid binding IEA Pleckstrin homology-like domain family A member 2; Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein; Imprinted in placenta and liver protein; Tumor-suppressing STF cDNA 3 protein; Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein; p17-Beckwith-Wiedemann region 1 C; p17-BWR1C 10594239 10749982 13129680 15314611 15457853 15489334 16584773 17303335 18669648 18691976 19203586 19369195 20068231 9328465 9403053 9520460 NA PHLA2 1 Pleckstrin homology-like domain family A member 2 Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein Imprinted in placenta and liver protein Tumor-suppressing STF cDNA 3 protein Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein p17-Beckwith-Wiedemann region 1 C p17-BWR1C gene 1291 0.0347288524571649 N - Not Matched cytoplasm IC Notch signaling pathway ISS GDP-mannose metabolic process IDA 'de novo' GDP-L-fucose biosynthetic process IDA GDP-mannose 4,6-dehydratase activity IDA GDP-mannose 4,6 dehydratase; 4.2.1.47; GDP-D-mannose dehydratase; GMD 14574404 15489334 21269460 9525924 9603974 NA GMDS 1 GDP-mannose 4,6 dehydratase 4.2.1.47 GDP-D-mannose dehydratase GMD gene 1291 0.192219042941373 HYAL1 D - Genome Maintenance cytoplasmic vesicle IDA extracellular space IDA lysosomal lumen TAS positive regulation of epithelial cell proliferation IDA negative regulation of cell growth IDA cartilage development IEP carbohydrate metabolic process TAS positive regulation of cell growth IMP response to virus IDA positive regulation of angiogenesis IDA positive regulation of cell adhesion IMP chondroitin sulfate catabolic process TAS inflammatory response IDA hyaluronan biosynthetic process IDA positive regulation of S phase of mitotic cell cycle IDA hyaluronan catabolic process IDA response to reactive oxygen species IDA response to antibiotic IDA hyalurononglucosaminidase activity IDA hyaluronan synthase activity IDA transcription factor binding IDA Hyaluronidase-1; Hyal-1; 3.2.1.35; Hyaluronoglucosaminidase-1; Lung carcinoma protein 1; LuCa-1; Precursor 10339581 10702795 12084718 15489334 16641997 17503783 8603390 9223416 NA HYAL1 -1 Hyaluronidase-1 Hyal-1 3.2.1.35 Hyaluronoglucosaminidase-1 Lung carcinoma protein 1 LuCa-1 Precursor gene 1291 0.00650852447032351 C - Cellular Fate and Organization integrin complex TAS hemidesmosome IDA basal plasma membrane IEA cell surface IDA leading edge IDA basement membrane IEA cell-matrix adhesion IEA integrin-mediated signaling pathway IEA cell motility involved in cell locomotion IMP response to wounding IDA hemidesmosome assembly IDA multicellular organismal development IEA filopodium formation IEA cell adhesion NAS receptor activity IEA Integrin beta-4; GP150; CD104; Precursor 10428948 10637308 10792571 10873890 11251584 11289717 11328943 11375975 12482924 15489334 16335952 16625196 16964243 18691976 19369195 19403692 1976638 21269460 2311577 2311578 2542022 7982032 9166594 9194858 9207246 9422533 9546354 9792864 9892956 NA ITB4 1 Integrin beta-4 GP150 CD104 Precursor gene 1291 0.300262688080211 PTPN1 C - Cellular Fate and Organization endoplasmic reticulum IDA endoplasmic reticulum membrane IEA cytoplasmic vesicle IEA early endosome IDA cytosol TAS insulin receptor signaling pathway IEA actin cytoskeleton reorganization IMP regulation of endocytosis IDA negative regulation of insulin receptor signaling pathway NAS platelet activation TAS unfolded protein response IDA zinc ion binding IDA protein tyrosine phosphatase activity IDA Tyrosine-protein phosphatase non-receptor type 1; 3.1.3.48; Protein-tyrosine phosphatase 1B; PTP-1B 10480872 11579209 11780052 12802338 12802339 15489334 15592455 15919835 1739967 18691976 20068231 21135139 21269460 21406692 2157211 2164224 22169477 2546149 8128219 8491187 9355745 9391040 9553104 9922143 NA PTN1 -1 Tyrosine-protein phosphatase non-receptor type 1 3.1.3.48 Protein-tyrosine phosphatase 1B PTP-1B gene 1470 1.0 C - Cellular Fate and Organization nucleolus IDA nucleoplasm TAS positive regulation of cell proliferation IEA gluconeogenesis IEA unfolded protein response, activation of signaling protein activity TAS negative regulation of transcription, DNA-dependent IEA transcription, DNA-dependent IEA sequence-specific DNA binding IEA transcription factor activity TAS transcription corepressor activity TAS Cyclic AMP-dependent transcription factor ATF-3; cAMP-dependent transcription factor ATF-3; Activating transcription factor 3 12034827 12881527 14702039 14759258 15489334 16710414 2516827 7515060 NA ATF3 0 Cyclic AMP-dependent transcription factor ATF-3 cAMP-dependent transcription factor ATF-3 Activating transcription factor 3 TF 1291 0.00655360402115204 ITGAL C - Cellular Fate and Organization immunological synapse IEA integrin complex NAS external side of plasma membrane IEA positive regulation of cell-cell adhesion IEA leukocyte migration TAS positive regulation of calcium-mediated signaling IEA signal transduction NAS inflammatory response NAS integrin-mediated signaling pathway IEA blood coagulation TAS T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IMP positive regulation of T cell proliferation IEA regulation of immune response TAS leukocyte adhesion IMP activated T cell proliferation IEA heterophilic cell adhesion IMP metal ion binding IEA Integrin alpha-L; CD11 antigen-like family member A; Leukocyte adhesion glycoprotein LFA-1 alpha chain; LFA-1A; Leukocyte function-associated molecule 1 alpha chain; CD11a; Precursor 10493829 10493852 12526797 15489334 15616553 19349973 2537322 7479767 8097887 8099450 8103515 8805579 NA ITAL -1 Integrin alpha-L CD11 antigen-like family member A Leukocyte adhesion glycoprotein LFA-1 alpha chain LFA-1A Leukocyte function-associated molecule 1 alpha chain CD11a Precursor gene 1291 0.0385082947407456 PTPRN2 C - Cellular Fate and Organization integral to plasma membrane TAS terminal button IEA endoplasmic reticulum lumen IEA secretory granule IEA transport vesicle membrane IEA transmembrane receptor protein tyrosine phosphatase activity TAS Receptor-type tyrosine-protein phosphatase N2; R-PTP-N2; 3.1.3.48; Islet cell autoantigen-related protein; IAR; ICAAR; Phogrin; Precursor 12168954 12853948 15489334 16959974 19167335 19608861 8798755 8878534 8954911 9205841 NA PTPR2 -1 Receptor-type tyrosine-protein phosphatase N2 R-PTP-N2 3.1.3.48 Islet cell autoantigen-related protein IAR ICAAR Phogrin Precursor gene 1291 0.17273753523313 TNFSF12 C - Cellular Fate and Organization perinuclear region IDA integral to plasma membrane TAS extracellular space IEA signal transduction TAS immune response IEA positive regulation of endothelial cell proliferation TAS endothelial cell migration TAS apoptosis IEA angiogenesis IEA induction of apoptosis TAS cell differentiation IEA positive regulation of angiogenesis TAS receptor binding TAS cytokine activity TAS Tumor necrosis factor ligand superfamily member 12; APO3 ligand; TNF-related weak inducer of apoptosis; TWEAK; Tumor necrosis factor ligand superfamily member 12, membrane form; Tumor necrosis factor ligand superfamily member 12, secreted form 10085077 12411489 12787562 12975309 14961121 15489334 16625196 9405449 9560343 NA TNF12 -1 Tumor necrosis factor ligand superfamily member 12 APO3 ligand TNF-related weak inducer of apoptosis TWEAK Tumor necrosis factor ligand superfamily member 12, membrane form Tumor necrosis factor ligand superfamily member 12, secreted form gene 1358 0.0394304743082529 BICD2 C - Cellular Fate and Organization Golgi apparatus IDA plasma membrane IDA cytoplasmic vesicle ISS cytoskeleton IEA Rab GTPase binding ISS Protein bicaudal D homolog 2; Bic-D 2 11864968 15144186 15164053 15489334 17081983 18669648 18691976 19690332 20068231 21269460 21406692 9734811 NA BICD2 -1 Protein bicaudal D homolog 2 Bic-D 2 gene 1291 0.00364891215556536 TNFSF10 C - Cellular Fate and Organization integral to plasma membrane TAS extracellular region TAS extracellular space IEA signal transduction TAS immune response IEA caspase activation TAS cell-cell signaling TAS induction of apoptosis TAS positive regulation of I-kappaB kinase/NF-kappaB cascade IEP receptor binding TAS metal ion binding IEA Tumor necrosis factor ligand superfamily member 10; Apo-2 ligand; Apo-2L; TNF-related apoptosis-inducing ligand; Protein TRAIL; CD253 10485660 10542098 10549288 14702039 15489334 16641997 21859711 8663110 8777713 NA TNF10 -1 Tumor necrosis factor ligand superfamily member 10 Apo-2 ligand Apo-2L TNF-related apoptosis-inducing ligand Protein TRAIL CD253 gene 1291 0.0156254591014239 TRRAP D - Genome Maintenance PCAF complex NAS STAGA complex IDA NuA4 histone acetyltransferase complex IDA histone deubiquitination IDA regulation of transcription, DNA-dependent IEA mitotic checkpoint IEA transcription, DNA-dependent IEA transcription cofactor activity IDA transcription coactivator activity IEA phosphotransferase activity, alcohol group as acceptor IEA Transformation/transcription domain-associated protein; 350/400 kDa PCAF-associated factor; PAF350/400; STAF40; Tra1 homolog 10373431 10611234 10966108 11418595 11445536 11564863 11839798 12138177 12660246 12690205 12743606 12853948 14966270 17344846 17967892 18206972 18669648 18691976 19608861 20068231 20427287 21269460 21499247 9708738 9885574 NA TRRAP 1 Transformation/transcription domain-associated protein 350/400 kDa PCAF-associated factor PAF350/400 STAF40 Tra1 homolog gene 1291 0.0717764875999394 CRIM1 F - Protein Fate plasma membrane IEA extracellular region IEA integral to membrane TAS regulation of cell growth IEA negative regulation of enzyme activity IEA nervous system development TAS serine-type endopeptidase inhibitor activity IEA insulin-like growth factor receptor activity TAS Cysteine-rich motor neuron 1 protein; CRIM-1; Cysteine-rich repeat-containing protein S52; Processed cysteine-rich motor neuron 1 protein; Precursor 10642437 12464430 12805376 12975309 15340161 15489334 18669648 NA CRIM1 -1 Cysteine-rich motor neuron 1 protein CRIM-1 Cysteine-rich repeat-containing protein S52 Processed cysteine-rich motor neuron 1 protein Precursor gene 1291 5.31464159820238E-4 PPP2R5C D - Genome Maintenance protein phosphatase type 2A complex IDA nucleus IDA chromosome, pericentric region IDA signal transduction NAS DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis IMP negative regulation of cell proliferation IDA proteasomal ubiquitin-dependent protein catabolic process IMP DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IDA protein phosphatase type 2A regulator activity IDA Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform; PP2A B subunit isoform B'-gamma; PP2A B subunit isoform B56-gamma; PP2A B subunit isoform PR61-gamma; PP2A B subunit isoform R5-gamma; Renal carcinoma antigen NY-REN-29 10508479 12508121 14702039 16456541 16541025 16580887 17086192 17174897 17245430 17967874 18618707 19054851 19716788 7584044 7592815 8617797 8694763 8703017 NA 2A5G 1 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform PP2A B subunit isoform B'-gamma PP2A B subunit isoform B56-gamma PP2A B subunit isoform PR61-gamma PP2A B subunit isoform R5-gamma Renal carcinoma antigen NY-REN-29 gene 3445 0.164796102445872 TCF4 T - Transcription transcription factor complex ISS transcription initiation from RNA polymerase II promoter ISS positive regulation of neuron differentiation ISS negative regulation of transcription from RNA polymerase II promoter IEA protein-DNA complex assembly ISS protein heterodimerization activity ISS transcription corepressor activity IEA Transcription factor 4; TCF-4; Class B basic helix-loop-helix protein 19; bHLHb19; Immunoglobulin transcription factor 2; ITF-2; SL3-3 enhancer factor 2; SEF-2 14702039 15489334 16177791 1681116 17436254 17436255 17467953 18728071 19235238 2105528 21406692 21789225 22045651 2308860 9302263 NA ITF2 -1 Transcription factor 4 TCF-4 Class B basic helix-loop-helix protein 19 bHLHb19 Immunoglobulin transcription factor 2 ITF-2 SL3-3 enhancer factor 2 SEF-2 TF 1291 0.0390125786123686 RAB22A C - Cellular Fate and Organization phagocytic vesicle IDA plasma membrane IDA actin cytoskeleton IEA ruffle IEA early endosome IDA endosome membrane IEA small GTPase mediated signal transduction IEA endosome organization and biogenesis IEP protein transport IEA endocytosis IDA GTPase activity TAS GTP binding IEA GDP binding IDA Ras-related protein Rab-22A; Rab-22 10887961 11780052 14702039 15489334 16537905 21255211 21419809 21849477 NA RB22A 1 Ras-related protein Rab-22A Rab-22 gene 1291 0.068148169631386 AHNAK N - Not Matched nucleus NAS nervous system development NAS Neuroblast differentiation-associated protein AHNAK; Desmoyokin 15489334 1608957 16554811 16964243 17081983 17185750 17924679 18318008 18669648 18691976 19367720 19369195 19690332 20068231 21269460 21406692 NA AHNK -1 Neuroblast differentiation-associated protein AHNAK Desmoyokin gene 1291 0.0714360801321983 RTN1 A - Transport and Sensing integral to endoplasmic reticulum membrane TAS neuron differentiation IEP signal transducer activity NAS Reticulon-1; Neuroendocrine-specific protein 15489334 15922294 18088087 21269460 7685762 8833145 9560466 NA RTN1 -1 Reticulon-1 Neuroendocrine-specific protein gene 1291 0.0160033796822725 TMEM74B N - Not Matched integral to membrane IEA Transmembrane protein 74B 11780052 14702039 NA TM74B -1 Transmembrane protein 74B gene 1291 0.0240272120400372 ATP13A4 M - Other Metabolism integral to membrane IEA ATP biosynthetic process IEA ATP catabolic process IEA cation transport IEA ATP binding IEA metal ion binding IEA ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism IEA Probable cation-transporting ATPase 13A4; 3.6.3.-; P5-ATPase isoform 4 12975309 14702039 15489334 15925480 16641997 17974005 NA AT134 -1 Probable cation-transporting ATPase 13A4 3.6.3.- P5-ATPase isoform 4 gene 1291 0.0886312797080639 ITGA5 C - Cellular Fate and Organization integrin complex TAS synapse IEA ruffle TAS external side of plasma membrane IEA positive regulation of vascular endothelial growth factor receptor signaling pathway TAS wound healing, spreading of epidermal cells IEP positive regulation of peptidyl-tyrosine phosphorylation IMP angiogenesis TAS leukocyte migration TAS integrin-mediated signaling pathway IEA axon guidance TAS blood coagulation TAS virus-host interaction IEA leukocyte adhesion IEA cell-substrate junction assembly IEA memory IEA cell adhesion TAS heterophilic cell adhesion IEA vascular endothelial growth factor receptor 2 binding TAS platelet-derived growth factor receptor binding TAS metal ion binding IEA Integrin alpha-5; CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD49e; Integrin alpha-5 heavy chain; Integrin alpha-5 light chain; Precursor 10397733 11912194 14596610 15489334 16051604 16754960 1834647 19159218 19349973 21269460 22451694 22740495 2450560 2944883 2958481 3033641 NA ITA5 -1 Integrin alpha-5 CD49 antigen-like family member E Fibronectin receptor subunit alpha Integrin alpha-F VLA-5 CD49e Integrin alpha-5 heavy chain Integrin alpha-5 light chain Precursor gene 2657 0.0367251672414937 C - Cellular Fate and Organization mitochondrion IEA protein complex IEA melanosome IEA perinuclear region IEA postsynaptic density IEA nucleoplasm TAS leading edge IEA cytosol TAS signal transduction TAS negative regulation of apoptosis TAS histamine secretion by mast cell IEA mRNA metabolic process TAS protein targeting to mitochondrion IEA platelet activation TAS 14-3-3 protein zeta/delta; Protein kinase C inhibitor protein 1; KCIP-1 10455159 10488331 11336675 11427721 11956222 12665801 12865427 14578935 14702039 14970201 15071501 15159416 15489334 15644438 15660133 15696159 1577711 15883165 16114898 16246723 16376338 17081065 17081983 17235285 17913709 18691976 19172738 19608861 19690332 20068231 21269460 21406692 9360956 9512661 NA 1433Z 1 14-3-3 protein zeta/delta Protein kinase C inhibitor protein 1 KCIP-1 gene 1291 0.145385885608534 ESRP1 T - Transcription plasma membrane IDA nucleus IDA mRNA processing IEA RNA splicing IEA regulation of RNA splicing IDA nucleotide binding IEA mRNA binding IDA Epithelial splicing regulatory protein 1; RNA-binding motif protein 35A; RNA-binding protein 35A 14702039 15489334 16421571 17974005 19285943 NA ESRP1 1 Epithelial splicing regulatory protein 1 RNA-binding motif protein 35A RNA-binding protein 35A gene 1291 0.00415489084742234 SELP C - Cellular Fate and Organization platelet dense granule membrane TAS integral to plasma membrane TAS platelet alpha granule membrane IDA nucleus IDA extracellular space IDA external side of plasma membrane IDA defense response to Gram-negative bacterium IC inflammatory response IEA platelet degranulation TAS positive regulation of leukocyte migration IEA leukocyte adhesion IDA response to lipopolysaccharide IC platelet activation TAS positive regulation of phosphoinositide 3-kinase cascade IDA leukocyte migration TAS leukocyte tethering or rolling IEA heterophilic cell adhesion IEA lipopolysaccharide binding IMP glycosphingolipid binding TAS fucose binding IDA heparin binding IDA P-selectin; CD62 antigen-like family member P; Granule membrane protein 140; GMP-140; Leukocyte-endothelial cell adhesion molecule 3; LECAM3; Platelet activation dependent granule-external membrane protein; PADGEM; CD62P; Precursor 10391209 11081633 11237770 14681304 15769472 16263699 16710414 18606703 2466574 7505680 7559387 7585949 7585950 7684381 8901515 9668170 NA LYAM3 -1 P-selectin CD62 antigen-like family member P Granule membrane protein 140 GMP-140 Leukocyte-endothelial cell adhesion molecule 3 LECAM3 Platelet activation dependent granule-external membrane protein PADGEM CD62P Precursor gene 1291 0.00458201074186734 ID4 D - Genome Maintenance cytoplasm IEA nucleus IC positive regulation of cell proliferation IEA regulation of transcription from RNA polymerase II promoter TAS myelination in the central nervous system IEA negative regulation of fat cell differentiation IEA negative regulation of transcription from RNA polymerase II promoter IEA neuroblast proliferation IEA negative regulation of astrocyte differentiation IEA positive regulation of osteoblast differentiation IEA hippocampus development IEA G1/S transition of mitotic cell cycle IEA negative regulation of neuron differentiation IEA positive regulation of transcription from RNA polymerase II promoter IEA negative regulation of oligodendrocyte differentiation IEA fat cell differentiation IEA negative regulation of transcription, DNA-dependent IDA cerebral cortex neuron differentiation IEA transcription corepressor activity TAS DNA-binding protein inhibitor ID-4; Class B basic helix-loop-helix protein 27; bHLHb27; Inhibitor of DNA binding 4 14574404 15489334 7665172 9872455 NA ID4 -1 DNA-binding protein inhibitor ID-4 Class B basic helix-loop-helix protein 27 bHLHb27 Inhibitor of DNA binding 4 gene 1361 0.0677139781813563 ID3 D - Genome Maintenance cytoplasm IEA nucleus IC metanephros development IEA positive regulation of apoptosis IEA response to wounding IEA multicellular organismal development TAS negative regulation of transcription from RNA polymerase II promoter IEA central nervous system development IEA negative regulation of transcription factor activity IDA transcription, DNA-dependent IEA heart development IEA negative regulation of osteoblast differentiation IEA neuron differentiation IEA epithelial cell differentiation IEA odontogenesis IEA regulation of cell cycle IEA notochord development IEA negative regulation of transcription, DNA-dependent IDA regulation of DNA replication IEA transcription factor activity IEA transcription corepressor activity TAS DNA-binding protein inhibitor ID-3; Class B basic helix-loop-helix protein 25; bHLHb25; Helix-loop-helix protein HEIR-1; ID-like protein inhibitor HLH 1R21; Inhibitor of DNA binding 3 14702039 15489334 1628620 16710414 7828896 8437843 NA ID3 -1 DNA-binding protein inhibitor ID-3 Class B basic helix-loop-helix protein 25 bHLHb25 Helix-loop-helix protein HEIR-1 ID-like protein inhibitor HLH 1R21 Inhibitor of DNA binding 3 gene 1640 0.0344958125629485 KDM5B T - Transcription nucleolus IDA negative regulation of transcription, DNA-dependent IDA transcription, DNA-dependent IEA transcription factor activity TAS transcription corepressor activity IDA oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IEA zinc ion binding IEA oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA DNA binding IDA Lysine-specific demethylase 5B; 1.14.11.-; Cancer/testis antigen 31; CT31; Histone demethylase JARID1B; Jumonji/ARID domain-containing protein 1B; PLU-1; Retinoblastoma-binding protein 2 homolog 1; RBP2-H1 10336460 10616211 10878660 12237901 12657635 15803180 16645588 16710414 17311883 17320161 17363312 17373667 18669648 NA KDM5B 1 Lysine-specific demethylase 5B 1.14.11.- Cancer/testis antigen 31 CT31 Histone demethylase JARID1B Jumonji/ARID domain-containing protein 1B PLU-1 Retinoblastoma-binding protein 2 homolog 1 RBP2-H1 gene 1291 0.0947091236009375 PPIL1 P - Translation protein peptidyl-prolyl isomerization IEA nuclear mRNA splicing, via spliceosome IC protein folding IEA peptidyl-prolyl cis-trans isomerase activity IEA Peptidyl-prolyl cis-trans isomerase-like 1; PPIase; 5.2.1.8; Rotamase PPIL1 10810093 11991638 12975309 14574404 15489334 16595688 20368803 21269460 8978786 NA PPIL1 1 Peptidyl-prolyl cis-trans isomerase-like 1 PPIase 5.2.1.8 Rotamase PPIL1 gene 1291 0.0947091236009375 CEACAM5 N - Not Matched basolateral plasma membrane IDA integral to plasma membrane TAS anchored to membrane IEA Carcinoembryonic antigen-related cell adhesion molecule 5; Carcinoembryonic antigen; CEA; Meconium antigen 100; CD66e; Precursor 10854848 10864933 15057824 16740002 18086185 19159218 2342461 3033671 3220478 3670312 3814146 NA CEAM5 1 Carcinoembryonic antigen-related cell adhesion molecule 5 Carcinoembryonic antigen CEA Meconium antigen 100 CD66e Precursor gene 1291 9.55249387324179E-6 PPP1R12B C - Cellular Fate and Organization cytoplasm IEA plasma membrane IDA actin cytoskeleton IDA signal transduction TAS regulation of muscle contraction TAS enzyme activator activity TAS Protein phosphatase 1 regulatory subunit 12B; Myosin phosphatase-targeting subunit 2; Myosin phosphatase target subunit 2 11067852 12923170 15489334 16710414 9570949 NA MYPT2 -1 Protein phosphatase 1 regulatory subunit 12B Myosin phosphatase-targeting subunit 2 Myosin phosphatase target subunit 2 gene 2124 0.0441454008772677 SELE C - Cellular Fate and Organization coated pit IDA perinuclear region IDA caveola IDA cortical cytoskeleton IDA integral to membrane IEA extracellular space IDA actin filament-based process IDA calcium-mediated signaling TAS leukocyte migration during inflammatory response TAS positive regulation of leukocyte migration IEA response to lipopolysaccharide TAS regulation of inflammatory response TAS phospholipase C activation IMP leukocyte tethering or rolling IMP positive regulation of receptor internalization IDA heterophilic cell adhesion IMP phospholipase binding IDA transmembrane receptor activity IMP E-selectin; CD62 antigen-like family member E; Endothelial leukocyte adhesion molecule 1; ELAM-1; Leukocyte-endothelial cell adhesion molecule 2; LECAM2; CD62E; Precursor 10391210 10982036 11081633 15489334 16710414 1689848 1701274 1703529 18606703 2466335 7509040 7533025 7681016 8557254 9933738 NA LYAM2 -1 E-selectin CD62 antigen-like family member E Endothelial leukocyte adhesion molecule 1 ELAM-1 Leukocyte-endothelial cell adhesion molecule 2 LECAM2 CD62E Precursor gene 1291 0.245263346839975 XPR1 A - Transport and Sensing integral to plasma membrane TAS response to virus IEA G-protein coupled receptor activity TAS Xenotropic and polytropic retrovirus receptor 1; Protein SYG1 homolog; Xenotropic and polytropic murine leukemia virus receptor X3; X-receptor 15489334 16710414 17081983 17974005 18669648 20068231 9927670 9988277 9990033 NA XPR1 1 Xenotropic and polytropic retrovirus receptor 1 Protein SYG1 homolog Xenotropic and polytropic murine leukemia virus receptor X3 X-receptor gene 1291 6.70900233782731E-4 DNAH14 M - Other Metabolism dynein complex IEA microtubule IEA cilium axoneme IEA microtubule-based movement IEA microtubule motor activity IEA ATP binding IEA Dynein heavy chain 14, axonemal; Axonemal beta dynein heavy chain 14; Ciliary dynein heavy chain 14 15489334 16710414 NA DYH14 1 Dynein heavy chain 14, axonemal Axonemal beta dynein heavy chain 14 Ciliary dynein heavy chain 14 gene 1291 8.71248705947511E-4 D - Genome Maintenance nuclear heterochromatin IEA PML body IDA nuclear matrix IEA histone methylation IEA establishment and/or maintenance of chromatin architecture TAS CD4-positive, alpha beta T cell differentiation IEA negative regulation of transcription from RNA polymerase II promoter IMP transcription, DNA-dependent IEA cell structure disassembly during apoptosis TAS epidermis development IEA CD8-positive, alpha-beta T cell differentiation IEA virus-host interaction IEA reflex process IEA chromatin remodeling IEA activated T cell proliferation IEA sequence-specific DNA binding IEA double-stranded DNA binding TAS transcription factor activity IEA chromatin binding IEA DNA-binding protein SATB1; Special AT-rich sequence-binding protein 1 10595394 10800076 11463840 12036295 12374985 12692553 14605447 14702039 1505028 15489334 15561718 15618465 15713622 15851481 15970696 16079286 16371359 16377216 16630892 16641997 17173041 17376900 17512569 17652321 18187506 18337816 18408014 19103759 19247486 19332023 19430959 9111059 9548713 NA SATB1 -1 DNA-binding protein SATB1 Special AT-rich sequence-binding protein 1 gene 2512 2.54441958951364E-6 ADCY9 C - Cellular Fate and Organization integral to plasma membrane TAS nerve growth factor receptor signaling pathway TAS energy reserve metabolic process TAS epidermal growth factor receptor signaling pathway TAS fibroblast growth factor receptor signaling pathway TAS synaptic transmission TAS water transport TAS G-protein signaling, adenylate cyclase activating pathway TAS phospholipase C activation TAS G-protein signaling, adenylate cyclase inhibiting pathway TAS adenylate cyclase activity TAS ATP binding IEA metal ion binding IEA Adenylate cyclase type 9; 4.6.1.1; ATP pyrophosphate-lyase 9; Adenylate cyclase type IX; Adenylyl cyclase 9 12168954 12972952 15489334 15879435 18669648 20068231 9628581 9628827 NA ADCY9 -1 Adenylate cyclase type 9 4.6.1.1 ATP pyrophosphate-lyase 9 Adenylate cyclase type IX Adenylyl cyclase 9 gene 1291 0.00550844870783072 CEACAM1 C - Cellular Fate and Organization integral to plasma membrane NAS extracellular region IEA cell migration NAS integrin-mediated signaling pathway NAS angiogenesis NAS homophilic cell adhesion NAS Carcinoembryonic antigen-related cell adhesion molecule 1; Biliary glycoprotein 1; BGP-1; CD66a; Precursor 11501563 15057824 15489334 16335952 16929097 19159218 2025273 21269460 2457922 2537311 7628460 8018919 8055923 8423792 NA CEAM1 1 Carcinoembryonic antigen-related cell adhesion molecule 1 Biliary glycoprotein 1 BGP-1 CD66a Precursor gene 1291 0.0031988344380112 RUNX1T1 C - Cellular Fate and Organization nucleus IEA nuclear matrix IDA regulation of DNA binding IEA fat cell differentiation IEA generation of precursor metabolites and energy TAS transcription, DNA-dependent IEA transcription factor activity TAS zinc ion binding IEA DNA binding IEA Protein CBFA2T1; Cyclin-D-related protein; Eight twenty one protein; Protein ETO; Protein MTG8; Zinc finger MYND domain-containing protein 2 10973986 12242670 1423235 14702039 15489334 16421571 16616331 16803958 16959974 17560331 17572682 21406692 7541640 7919324 8137293 8334990 8353289 9661669 NA MTG8 -1 Protein CBFA2T1 Cyclin-D-related protein Eight twenty one protein Protein ETO Protein MTG8 Zinc finger MYND domain-containing protein 2 gene 1291 0.122062164231375 DUSP7 C - Cellular Fate and Organization nucleoplasm TAS cytosol IDA Toll signaling pathway TAS nerve growth factor receptor signaling pathway TAS MyD88-dependent toll-like receptor signaling pathway TAS innate immune response TAS stress-activated MAPK cascade TAS protein tyrosine phosphatase activity IEA MAP kinase phosphatase activity IDA Dual specificity protein phosphatase 7; 3.1.3.16; 3.1.3.48; Dual specificity protein phosphatase PYST2 14576828 14603440 15489334 16641997 8670865 NA DUS7 -1 Dual specificity protein phosphatase 7 3.1.3.16 3.1.3.48 Dual specificity protein phosphatase PYST2 gene 1467 1.0 IRF8 C - Cellular Fate and Organization nucleus IEA cytosol TAS positive regulation of interferon-gamma production IEA phagocytosis IEA defense response to protozoan IEA myeloid cell differentiation IEA positive regulation of interleukin-12 production IEA negative regulation of transcription from RNA polymerase II promoter TAS positive regulation of transcription, DNA-dependent IEA defense response to bacterium IEA RNA polymerase II transcription factor activity, enhancer binding TAS Interferon regulatory factor 8; IRF-8; Interferon consensus sequence-binding protein; H-ICSBP; ICSBP 10991940 1460054 15489334 16959974 NA IRF8 0 Interferon regulatory factor 8 IRF-8 Interferon consensus sequence-binding protein H-ICSBP ICSBP TF 1291 0.0994998451839461 N - Not Matched plasma membrane IEA integral to membrane IEA Uroplakin-3b; UP3b; Uroplakin IIIb; UPIIIb; p35; Precursor 12446744 12853948 14702039 15489334 NA UPK3B -1 Uroplakin-3b UP3b Uroplakin IIIb UPIIIb p35 Precursor gene 1291 0.0160033796822725 DUSP1 D - Genome Maintenance nucleoplasm IBA response to hydrogen peroxide IEA response to calcium ion IEA endoderm formation IBA cell cycle IEA positive regulation of apoptosis IEA response to light stimulus IEA regulation of apoptosis IBA response to glucocorticoid stimulus IEA response to oxidative stress TAS response to estradiol stimulus IEA response to cAMP IEA protein tyrosine/threonine phosphatase activity IEA MAP kinase phosphatase activity IBA non-membrane spanning protein tyrosine phosphatase activity TAS Dual specificity protein phosphatase 1; 3.1.3.16; 3.1.3.48; Dual specificity protein phosphatase hVH1; Mitogen-activated protein kinase phosphatase 1; MAP kinase phosphatase 1; MKP-1; Protein-tyrosine phosphatase CL100 1406996 15489334 8106404 NA DUS1 -1 Dual specificity protein phosphatase 1 3.1.3.16 3.1.3.48 Dual specificity protein phosphatase hVH1 Mitogen-activated protein kinase phosphatase 1 MAP kinase phosphatase 1 MKP-1 Protein-tyrosine phosphatase CL100 gene 1508 0.20829202017642 P - Translation rough endoplasmic reticulum membrane IEA endoplasmic reticulum membrane TAS response to hypoxia IEP extracellular matrix organization and biogenesis TAS protein modification TAS L-ascorbic acid binding IEA iron ion binding IEA procollagen-lysine 5-dioxygenase activity TAS oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2; 1.14.11.4; Lysyl hydroxylase 2; LH2; Precursor 10372558 12881513 15489334 15523624 16641997 18088087 19159218 21269460 9054364 NA PLOD2 1 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 1.14.11.4 Lysyl hydroxylase 2 LH2 Precursor gene 1291 2.86417363433285E-4 SMYD3 N - Not Matched cytoplasm IEA nucleus IEA zinc ion binding IEA histone-lysine N-methyltransferase activity ISS Histone-lysine N-methyltransferase SMYD3; 2.1.1.43; SET and MYND domain-containing protein 3; Zinc finger MYND domain-containing protein 1 14702039 15235609 15489334 16710414 21269460 22419068 NA SMYD3 1 Histone-lysine N-methyltransferase SMYD3 2.1.1.43 SET and MYND domain-containing protein 3 Zinc finger MYND domain-containing protein 1 gene 1291 0.00287623944915697 PLOD1 P - Translation rough endoplasmic reticulum membrane IEA endoplasmic reticulum membrane TAS response to hypoxia IEP epidermis development IMP extracellular matrix organization and biogenesis TAS hydroxylysine biosynthetic process TAS protein modification NAS L-ascorbic acid binding IEA iron ion binding IEA procollagen-lysine 5-dioxygenase activity IEA oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA protein homodimerization activity TAS Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1; 1.14.11.4; Lysyl hydroxylase 1; LH1; Precursor 10686424 15489334 15666309 1577494 15854030 15979919 16710414 16959974 21269460 7713497 8163671 8621606 9617436 NA PLOD1 1 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 1.14.11.4 Lysyl hydroxylase 1 LH1 Precursor gene 4261 1.0 D - Genome Maintenance nuclear chromatin IDA nucleoplasm TAS cytosol TAS positive regulation of interferon-beta production IMP negative regulation of cell proliferation TAS transcription from RNA polymerase II promoter TAS induction of apoptosis IDA regulation of adaptive immune response TAS defense response to virus IDA positive regulation of interleukin-12 biosynthetic process IEA CD8-positive, alpha-beta T cell differentiation IEA blood coagulation TAS positive regulation of transcription from RNA polymerase II promoter IEA regulation of innate immune response TAS cell cycle arrest IDA protein amino acid phosphorylation IDA positive regulation of transcription, DNA-dependent IDA negative regulation of transcription, DNA-dependent IMP negative regulation of regulatory T cell differentiation ISS protein amino acid acetylation IDA transcription factor activity IEA Interferon regulatory factor 1; IRF-1 10094406 10395927 11244049 11846971 11846974 1382447 15226432 15489334 15509808 16932750 17516545 17942705 18084608 18497060 18641303 19404407 19851330 20049431 21389130 22200613 22367195 2726461 3409321 8438156 9679752 NA IRF1 0 Interferon regulatory factor 1 IRF-1 TF 1291 0.0714360801321983 NPR3 C - Cellular Fate and Organization integral to plasma membrane IC integral to membrane IEA skeletal development ISS positive regulation of nitric-oxide synthase activity ISS blood pressure regulation ISS G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) IEA negative regulation of adenylate cyclase activity IEA G-protein signaling, adenylate cyclase inhibiting pathway IEA natriuretic peptide receptor activity IDA peptide receptor activity, G-protein coupled ISS peptide hormone binding ISS Atrial natriuretic peptide receptor 3; Atrial natriuretic peptide clearance receptor; Atrial natriuretic peptide receptor type C; ANP-C; ANPR-C; NPR-C; Precursor 11533490 14702039 15372022 15489334 1660465 16870210 2162522 2169733 7727388 NA ANPRC -1 Atrial natriuretic peptide receptor 3 Atrial natriuretic peptide clearance receptor Atrial natriuretic peptide receptor type C ANP-C ANPR-C NPR-C Precursor gene 1291 0.152810214692298 NPR1 C - Cellular Fate and Organization integral to plasma membrane IC fluid secretion TAS regulation of vasodilation NAS negative regulation of cell growth NAS dopamine metabolic process IEA regulation of blood vessel size IEA negative regulation of angiogenesis TAS blood pressure regulation NAS regulation of vascular permeability TAS positive regulation of cGMP biosynthetic process IEA negative regulation of smooth muscle cell proliferation IEA receptor guanylyl cyclase signaling pathway IDA natriuretic peptide receptor activity IDA protein kinase activity IEA hormone binding IPI peptide receptor activity, G-protein coupled NAS guanylate cyclase activity IDA GTP binding IEA peptide hormone binding IEA ATP binding IEA Atrial natriuretic peptide receptor 1; 4.6.1.2; Atrial natriuretic peptide receptor type A; ANP-A; ANPR-A; NPR-A; Guanylate cyclase A; GC-A; Precursor 15489334 1660465 16710414 1672777 17344846 20977274 2569967 7954658 9618281 NA ANPRA -1 Atrial natriuretic peptide receptor 1 4.6.1.2 Atrial natriuretic peptide receptor type A ANP-A ANPR-A NPR-A Guanylate cyclase A GC-A Precursor gene 1291 0.0364421506327492 ITPR1 C - Cellular Fate and Organization platelet dense granule membrane IDA endoplasmic reticulum membrane TAS integral to membrane IEA platelet dense tubular network membrane TAS response to hypoxia IDA nerve growth factor receptor signaling pathway TAS energy reserve metabolic process TAS release of sequestered calcium ion into cytosol ISS epidermal growth factor receptor signaling pathway TAS regulation of insulin secretion TAS fibroblast growth factor receptor signaling pathway TAS platelet activation TAS phospholipase C activation TAS inositol 1,4,5-triphosphate-sensitive calcium-release channel activity ISS phosphoinositide binding ISS intracellular ligand-gated calcium channel activity ISS Inositol 1,4,5-trisphosphate receptor type 1; IP3 receptor isoform 1; IP3R 1; InsP3R1; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptor 12032348 14685260 15652484 16641997 16990611 17081983 17590087 18669648 19159218 20068231 7500840 7852357 7945203 8648241 NA ITPR1 -1 Inositol 1,4,5-trisphosphate receptor type 1 IP3 receptor isoform 1 IP3R 1 InsP3R1 Type 1 inositol 1,4,5-trisphosphate receptor Type 1 InsP3 receptor gene 69111 0.0316785435941804 novel 1 mir 1291 0.030922008657682 C - Cellular Fate and Organization cytoplasm IDA cytoplasmic vesicle IEA protein amino acid autophosphorylation TAS anoikis IMP induction of apoptosis IMP protein kinase cascade IDA calmodulin binding IDA calmodulin regulated protein kinase activity TAS ATP binding IDA Death-associated protein kinase 2; DAP kinase 2; 2.7.11.1; DAP-kinase-related protein 1; DRP-1 10376525 10629061 11230133 11980920 12445458 15489334 16756490 17344846 17347302 18669648 18957423 21408167 NA DAPK2 -1 Death-associated protein kinase 2 DAP kinase 2 2.7.11.1 DAP-kinase-related protein 1 DRP-1 gene 1421 2.50507620897504E-5 DAPK1 C - Cellular Fate and Organization cytoplasm IEA actin cytoskeleton IDA negative regulation of protein biosynthetic process IDA negative regulation of apoptosis IEA protein amino acid autophosphorylation TAS induction of apoptosis IMP protein kinase cascade IDA calmodulin binding IDA protein serine/threonine kinase activity TAS ATP binding IDA Death-associated protein kinase 1; DAP kinase 1; 2.7.11.1 10629061 11573098 11579085 11980920 12730201 14505650 14702039 15164053 15367680 15489334 15616583 15729359 16132846 16213824 16756490 17056602 17344846 17703233 17895359 17974005 18195017 18422656 18974095 18995835 19180116 19878313 20389280 21406692 21408167 21497122 7828849 NA DAPK1 -1 Death-associated protein kinase 1 DAP kinase 1 2.7.11.1 gene 1291 0.0958343609500199 C - Cellular Fate and Organization cytoplasm IDA plasma membrane IBA signal transduction IEA regulation of G-protein coupled receptor protein signaling pathway TAS GTPase activator activity IBA Regulator of G-protein signaling 5; RGS5 10471929 15489334 15670159 16710414 17974005 9747037 NA RGS5 -1 Regulator of G-protein signaling 5 RGS5 gene 1291 0.00874128630945346 C - Cellular Fate and Organization plasma membrane IBA nucleus IEA cytosol TAS inactivation of MAPK activity TAS regulation of G-protein coupled receptor protein signaling pathway TAS GTPase activator activity IBA Regulator of G-protein signaling 3; RGP3; RGS3 10749886 11294858 12036301 14702039 15164053 15489334 16884686 17487921 8602223 9858594 NA RGS3 1 Regulator of G-protein signaling 3 RGP3 RGS3 gene 1291 0.0555521932186291 PRNP D - Genome Maintenance Golgi apparatus ISS plasma membrane ISS endoplasmic reticulum ISS nucleolus IDA lipid raft ISS anchored to membrane IEA extrinsic to membrane TAS negative regulation of interleukin-2 production ISS negative regulation of apoptosis IEA negative regulation of activated T cell proliferation ISS negative regulation of T cell receptor signaling pathway ISS negative regulation of transcription factor activity ISS negative regulation of interleukin-17 production ISS copper ion homeostasis NAS axon guidance TAS metabolic process TAS learning and/or memory IEA negative regulation of protein amino acid phosphorylation ISS protein homooligomerization IEA cell cycle arrest IEA response to copper ion IEA negative regulation of interferon-gamma production ISS response to oxidative stress ISS response to cadmium ion IEA microtubule binding IDA copper ion binding IDA Major prion protein; PrP; ASCR; PrP27-30; PrP33-35C; CD230; Precursor 10581485 10618385 10631141 10790216 10900000 10954699 10987652 11524679 11709001 11780052 11900542 12732622 1347910 1363802 1363810 14623188 15489334 16144413 1671440 1672107 1678248 1683708 17468747 18034490 19059915 19204296 19349973 19381258 1975028 19927125 19936054 20375014 20564047 21153684 2564168 2783132 3014653 3755672 7485229 7699395 7783876 7902693 7902972 7906019 7913755 8105771 8364585 8461023 8797472 8909447 9266722 9384372 9786248 9799790 NA PRIO -1 Major prion protein PrP ASCR PrP27-30 PrP33-35C CD230 Precursor gene 1291 0.0385082947407456 RGS2 D - Genome Maintenance mitochondrion IEA nucleolus IEA internal side of plasma membrane ISS cytosol ISS cell cycle IEA negative regulation of G-protein coupled receptor protein signaling pathway ISS brown fat cell differentiation IEA negative regulation of MAPK activity ISS spermatogenesis IEA regulation of translation IEA calmodulin binding TAS GTPase activator activity IBA Regulator of G-protein signaling 2; RGS2; Cell growth-inhibiting gene 31 protein; G0/G1 switch regulatory protein 8 11063746 11278586 14608379 14702039 15489334 16710414 17901199 18434541 19736320 7643615 8179820 NA RGS2 -1 Regulator of G-protein signaling 2 RGS2 Cell growth-inhibiting gene 31 protein G0/G1 switch regulatory protein 8 gene 1291 0.132944022742685 R3HDM1 N - Not Matched nucleic acid binding IEA R3H domain-containing protein 1 15144186 15489334 18669648 19690332 20068231 21406692 7584026 NA R3HD1 1 R3H domain-containing protein 1 gene 1291 3.37587041563912E-5 WIF1 C - Cellular Fate and Organization extracellular region IEA signal transduction NAS positive regulation of fat cell differentiation IEA multicellular organismal development IEA Wnt receptor signaling pathway IEA Wnt inhibitory factor 1; WIF-1; Precursor 10201374 12975309 15489334 16476441 NA WIF1 -1 Wnt inhibitory factor 1 WIF-1 Precursor gene 1291 0.619654513870173 PPM1F T - Transcription protein complex IDA perinuclear region IEA cytosol IDA positive regulation of caspase activity IDA positive regulation of chemotaxis IMP positive regulation of stress fiber formation IDA positive regulation of focal adhesion formation IMP negative regulation of transcription, DNA-dependent IMP positive regulation of growth IMP metal ion binding IEA Protein phosphatase 1F; 3.1.3.16; Ca(2+)/calmodulin-dependent protein kinase phosphatase; CaM-kinase phosphatase; CaMKPase; Partner of PIX 2; Protein fem-2 homolog; hFem-2 11559703 11864573 14702039 16959974 20068231 21269460 7584026 NA PPM1F -1 Protein phosphatase 1F 3.1.3.16 Ca(2+)/calmodulin-dependent protein kinase phosphatase CaM-kinase phosphatase CaMKPase Partner of PIX 2 Protein fem-2 homolog hFem-2 gene 1291 0.325044433804753 ADD1 C - Cellular Fate and Organization perinuclear region IEA plasma membrane IEA postsynaptic density IEA nucleus IDA F-actin capping protein complex IDA cytosol TAS hemoglobin metabolic process IEA embryonic development (sensu Mammalia) IEA cell structure disassembly during apoptosis TAS positive regulation of angiogenesis IEA regulation of cell volume IEA positive regulation of protein binding IDA positive regulation of endocytosis IEA cell morphogenesis IEA barbed-end actin filament capping IDA homeostasis of number of cells within a tissue IEA body growth IEA erythrocyte differentiation IEA unfolded protein response, activation of signaling protein activity TAS actin filament bundle formation IDA actin filament binding IDA structural molecule activity IEA spectrin binding IDA metal ion binding IEA Alpha-adducin; Erythrocyte adducin subunit alpha 10209029 10391210 1345173 15815621 17081983 18088087 1840603 18669648 19690332 20068231 21269460 21406692 7774961 8810272 9674650 NA ADDA -1 Alpha-adducin Erythrocyte adducin subunit alpha gene 1291 0.00997161185978084 CCNE1 D - Genome Maintenance cyclin-dependent protein kinase holoenzyme complex IEA nucleoplasm TAS cytosol TAS G1/S-specific transcription in mitotic cell cycle TAS DNA replication initiation IEA protein amino acid phosphorylation IMP regulation of cyclin-dependent protein kinase activity IEA Wnt receptor signaling pathway IEA positive regulation of transcription, DNA-dependent NAS androgen receptor signaling pathway NAS cell division IEA kinase activity IEA transcription coactivator activity NAS cyclin-dependent protein kinase regulator activity IEA androgen receptor binding NAS G1/S-specific cyclin-E1 14536078 14702039 15178429 15489334 1833066 1833068 18669648 18691976 19369195 21952639 7739542 8207080 8649818 8833152 8861947 9840943 NA CCNE1 1 G1/S-specific cyclin-E1 gene 5274 0.00374688243165383 C - Cellular Fate and Organization plasma membrane TAS cell surface IDA extracellular space IDA response to hypoxia IEA signal transduction TAS chemotaxis TAS blood coagulation TAS regulation of cell proliferation IEA proteolysis TAS fibrinolysis TAS serine-type endopeptidase activity TAS Urokinase-type plasminogen activator; U-plasminogen activator; uPA; 3.4.21.73; Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B; Precursor 10340997 10636902 10805774 11384978 1327118 14696115 14702039 15164054 15489334 15988036 16456079 18987736 20007542 2023947 2415429 2536903 2987867 3501295 3888571 6589620 6749491 6754569 6754572 8107091 8591045 8652631 9065988 9151681 9194591 NA UROK 1 Urokinase-type plasminogen activator U-plasminogen activator uPA 3.4.21.73 Urokinase-type plasminogen activator long chain A Urokinase-type plasminogen activator short chain A Urokinase-type plasminogen activator chain B Precursor gene 1291 0.0994998451839461 IP6K1 C - Cellular Fate and Organization cytoplasm IEA nucleolus IDA phosphoinositide phosphorylation IDA inositol trisphosphate 3-kinase activity IEA ATP binding IEA Inositol hexakisphosphate kinase 1; InsP6 kinase 1; 2.7.4.21; Inositol hexaphosphate kinase 1 11502751 14702039 15489334 16641997 18669648 9039502 NA IP6K1 -1 Inositol hexakisphosphate kinase 1 InsP6 kinase 1 2.7.4.21 Inositol hexaphosphate kinase 1 gene 1405 0.0160033796822725 BTK C - Cellular Fate and Organization plasma membrane IDA nucleus TAS lipid raft IDA cytoplasmic vesicle IEA cytosol IDA B cell receptor signaling pathway TAS calcium-mediated signaling TAS positive regulation of B cell differentiation TAS I-kappaB kinase/NF-kappaB cascade IEA peptidyl-tyrosine phosphorylation IEA regulation of B cell cytokine production TAS transcription, DNA-dependent IEA adaptive immune response TAS B cell activation TAS Toll signaling pathway TAS activation of NF-kappaB transcription factor TAS MyD88-dependent toll-like receptor signaling pathway TAS innate immune response TAS regulation of B cell apoptosis TAS mesoderm development TAS cell maturation IEA phosphatidylinositol-3,4,5-triphosphate binding IDA non-membrane spanning protein tyrosine kinase activity TAS ATP binding TAS metal ion binding IEA Tyrosine-protein kinase BTK; 2.7.10.2; Agammaglobulinemia tyrosine kinase; ATK; B-cell progenitor kinase; BPK; Bruton tyrosine kinase 10196129 10196179 10220140 10339589 10602036 10612838 10678660 10826882 11016936 11527964 11577348 11598012 11606584 11751885 12573241 15375214 15489334 15772651 16415872 16517732 16644721 16738337 16969585 17344846 17932028 19290921 19369195 19807924 20052711 21269460 21280133 7626884 7627183 7633420 7633429 7711734 7809124 7849006 7849697 7849721 7880320 7897635 7927535 8013627 8070576 8090769 8162018 8162056 8380905 8425221 8594569 8630736 8634718 8695804 8723128 8834236 9012831 9016530 9218782 9260159 9280283 9445504 9485443 9545398 9571151 9751072 NA BTK -1 Tyrosine-protein kinase BTK 2.7.10.2 Agammaglobulinemia tyrosine kinase ATK B-cell progenitor kinase BPK Bruton tyrosine kinase gene 1291 0.13818482481767 CRY2 D - Genome Maintenance cytoplasm IDA extracellular region IDA nucleus ISS protein-chromophore linkage IEA DNA repair IEA negative regulation of transcription from RNA polymerase II promoter IDA rhythmic process IEA transcription, DNA-dependent IEA damaged DNA binding IDA blue light photoreceptor activity NAS nucleotide binding IEA single-stranded DNA binding IDA DNA photolyase activity IEA Cryptochrome-2 10531061 14702039 15489334 16554811 17463251 8909283 9734811 9801304 NA CRY2 -1 Cryptochrome-2 gene 1605 0.443742622063426 C - Cellular Fate and Organization integral to plasma membrane TAS blood coagulation TAS cell adhesion TAS leukocyte tethering or rolling IEA leukocyte adhesive activation ISS bacterial cell surface binding TAS receptor binding NAS P-selectin glycoprotein ligand 1; PSGL-1; Selectin P ligand; CD162; Precursor 10713099 11081633 11566773 12387735 12403782 12736247 14702039 15489334 16541075 18196517 18669648 7505206 7521878 7541799 7559387 7585949 7585950 8702529 NA SELPL -1 P-selectin glycoprotein ligand 1 PSGL-1 Selectin P ligand CD162 Precursor gene 3559 0.034897023954615 NR3C1 T - Transcription membrane IEA mitochondrial matrix TAS nucleoplasm TAS cytosol IEA regulation of gluconeogenesis IEA transcription initiation from RNA polymerase II promoter TAS positive regulation of neuron apoptosis IEA adrenal gland development IEA glucocorticoid metabolic process IEA regulation of glucocorticoid biosynthetic process IEA chromatin modification IEA sequence-specific DNA binding IEA transcription factor activity TAS glucocorticoid receptor activity TAS zinc ion binding IEA steroid binding IEA Glucocorticoid receptor; GR; Nuclear receptor subfamily 3 group C member 1 10391209 10477749 10566686 10639135 10866662 10898924 10902803 11238589 11344238 11435610 11555652 11589680 11701741 11932321 12000743 12050230 12144530 12151000 12351458 12415108 12686538 15211577 15265776 15276593 15292341 15372022 15489334 15941832 16478993 16964243 1704018 1707881 17404046 17974005 18669648 18691976 1958537 19690332 20068231 2026589 20843780 21269460 21664385 21730050 2867473 3841189 7683692 8316249 8358712 8358735 8445027 9150737 9154805 9590696 NA GCR -1 Glucocorticoid receptor GR Nuclear receptor subfamily 3 group C member 1 TF 1377 1.0 ETV4 C - Cellular Fate and Organization nucleolus IDA nucleus IEA stem cell differentiation IEA motor axon guidance IEA positive regulation of transcription, DNA-dependent IEA transcription, DNA-dependent IEA sequence-specific DNA binding IEA transcription factor activity IEA ETS translocation variant 4; Adenovirus E1A enhancer-binding protein; E1A-F; Polyomavirus enhancer activator 3 homolog; Protein PEA3 10564827 14702039 15489334 16625196 18669648 19307308 7774926 8441666 NA ETV4 0 ETS translocation variant 4 Adenovirus E1A enhancer-binding protein E1A-F Polyomavirus enhancer activator 3 homolog Protein PEA3 TF 1291 0.00656102737184934 DPYSL2 C - Cellular Fate and Organization mitochondrion IEA protein complex IEA axon IEA cell soma IEA dendrite IEA cytosol TAS growth cone IEA spinal cord development IEA response to drug IEA synaptic vesicle transport IEA response to cocaine IEA positive regulation of glutamate secretion IEA signal transduction TAS response to amphetamine IEA nucleobase, nucleoside, nucleotide and nucleic acid metabolic process TAS olfactory bulb development IEA axon guidance TAS cytoskeleton organization and biogenesis ISS regulation of neuron differentiation IEA pyrimidine base catabolic process IEA dihydropyrimidinase activity TAS Dihydropyrimidinase-related protein 2; DRP-2; Collapsin response mediator protein 2; CRMP-2; N2A3; Unc-33-like phosphoprotein 2; ULIP-2 10574455 10757975 11477421 14685275 14702039 15466863 15489334 16260607 16421571 16959974 16964243 17250651 18669648 19235893 19652227 20068231 21269460 21406692 7637782 8973361 NA DPYL2 -1 Dihydropyrimidinase-related protein 2 DRP-2 Collapsin response mediator protein 2 CRMP-2 N2A3 Unc-33-like phosphoprotein 2 ULIP-2 gene 1291 0.218687921200834 ETV1 T - Transcription nucleus IEA muscle development IEA transcription from RNA polymerase II promoter TAS axon guidance IEA peripheral nervous system neuron development TAS mechanosensory behavior IEA positive regulation of transcription, DNA-dependent IEA sequence-specific DNA binding IEA transcription factor activity TAS ETS translocation variant 1; Ets-related protein 81 12213813 12569367 12690205 12853948 14702039 15489334 15561718 17974005 7651741 7700648 NA ETV1 -1 ETS translocation variant 1 Ets-related protein 81 gene 1291 0.00503499461286295 N - Not Matched integral to membrane IEA DNA binding TAS Lipoma HMGIC fusion partner; Precursor 10329012 14702039 15057823 15489334 NA LHFP -1 Lipoma HMGIC fusion partner Precursor gene 1601 0.0020013975967909 C - Cellular Fate and Organization endoplasmic reticulum lumen TAS extracellular space IDA collagen type I IMP response to hydrogen peroxide IEA blood vessel development IMP positive regulation of cell migration IDA response to nutrient IEA sensory perception of sound IMP embryonic skeletal development IMP response to peptide hormone stimulus IEA platelet activation TAS response to corticosteroid stimulus IEA leukocyte migration TAS protein transport IEA response to cAMP IEA osteoblast differentiation IEA endochondral ossification IEA intramembranous ossification IEA axon guidance TAS collagen fibril organization IMP skin morphogenesis IMP positive regulation of transcription, DNA-dependent IDA visual perception IMP platelet-derived growth factor binding IDA metal ion binding IEA extracellular matrix structural constituent IEA identical protein binding IDA Collagen alpha-1(I) chain; Alpha-1 type I collagen; Precursor 10408781 10627137 10739762 12660034 1460047 14749390 1511982 15489334 15864348 1613761 1634225 16566045 16638323 16705691 16786509 16879195 1718984 17206620 17211858 1737847 1770532 17875077 18272325 18670065 1870989 1874719 1895312 18996919 1939261 1953667 1988452 1995349 2010058 2035536 2036375 2037280 2116413 21344539 2169412 2211725 2295701 2318855 2339700 2374517 2470760 2511192 2745420 2767050 2777764 2794057 2822714 2843432 2857713 2913053 2981843 3016737 3108247 3170557 3178743 3244312 3340531 3403550 3480516 3667599 3857621 4319110 5529814 6183642 6462220 6689127 7520724 7679635 7691343 7881420 7961597 7982948 8019571 8094076 8100209 8223589 8339541 8349697 8349698 8364588 8456808 8456809 8669434 8723681 8786074 8841196 8988177 9101290 9101304 9143923 9443882 9535665 9600458 NA CO1A1 1 Collagen alpha-1(I) chain Alpha-1 type I collagen Precursor gene 1291 0.148472992584061 TYMS D - Genome Maintenance mitochondrial matrix IDA nucleolus IEA mitochondrial inner membrane IDA nucleoplasm TAS cytosol TAS response to organophosphorus IEP cartilage development IEA response to ethanol IEA organ regeneration IEA uracil metabolic process IEA developmental growth IEA pyrimidine nucleoside biosynthetic process TAS G1/S-specific transcription in mitotic cell cycle TAS tetrahydrofolate metabolic process IEA deoxyribonucleoside monophosphate biosynthetic process TAS immortalization of host cell by virus IEA polysaccharide metabolic process IEA response to drug IEA phosphoinositide-mediated signaling NAS aging IEA response to toxin IEA dTMP biosynthetic process IEA dUMP metabolic process IEA response to glucocorticoid stimulus IEA dTTP biosynthetic process IEA DNA replication NAS response to folic acid IEA DNA repair NAS circadian rhythm IEA pyrimidine base metabolic process TAS folic acid binding IEA cofactor binding IEA nucleotide binding IEA drug binding IEA mRNA binding IEA thymidylate synthase activity TAS Thymidylate synthase; TS; TSase; 2.1.1.45 11278511 11329255 15489334 19690332 21269460 21876188 2243092 2532645 2656695 2987839 3839505 8845352 NA TYSY 1 Thymidylate synthase TS TSase 2.1.1.45 gene 1511 0.0122601782364482 C - Cellular Fate and Organization cytoplasm IEA membrane IEA cyclin-dependent protein kinase holoenzyme complex IDA nucleus IEA signal transduction IEA T cell proliferation IEA positive regulation of cyclin-dependent protein kinase activity IDA cell division IEA cyclin-dependent protein kinase activity IEA G1/S-specific cyclin-D3 1383201 1386335 1386336 14574404 14702039 15327989 15358120 15489334 16782892 18669648 19237555 19690332 22020328 9106657 NA CCND3 -1 G1/S-specific cyclin-D3 gene 1291 0.0684467560661034 FUT6 F - Protein Fate Golgi apparatus TAS integral to membrane IEA L-fucose catabolic process NAS protein amino acid glycosylation TAS 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity IEA alpha(1,3)-fucosyltransferase activity TAS Alpha-(1,3)-fucosyltransferase; 2.4.1.65; Fucosyltransferase 6; Fucosyltransferase VI; Fuc-TVI; FucT-VI; Galactoside 3-L-fucosyltransferase 11102976 1339443 15057824 1520296 7650030 8175676 NA FUT6 1 Alpha-(1,3)-fucosyltransferase 2.4.1.65 Fucosyltransferase 6 Fucosyltransferase VI Fuc-TVI FucT-VI Galactoside 3-L-fucosyltransferase gene 1493 4.95158714970261E-4 D - Genome Maintenance nuclear membrane IDA cyclin-dependent protein kinase holoenzyme complex IDA nucleolus IDA chromatin IDA cytosol IDA cell cycle IEA positive regulation of cyclin-dependent protein kinase activity IDA cell division IEA G1/S-specific cyclin-D2 1386335 1386336 14702039 15489334 18827403 22323446 8455931 NA CCND2 -1 G1/S-specific cyclin-D2 gene 2976 0.0031988344380112 CYYR1 N - Not Matched integral to membrane NAS Cysteine and tyrosine-rich protein 1; Proline-rich domain-containing protein; Precursor 10830953 12036297 12062809 14702039 15489334 17442112 17974005 NA CYYR1 -1 Cysteine and tyrosine-rich protein 1 Proline-rich domain-containing protein Precursor gene 1291 0.00159110698483979 T - Transcription nucleus IEA regulation of transcription, DNA-dependent IEA transcription, DNA-dependent IEA Transcription cofactor vestigial-like protein 3; Vgl-3 12376544 15489334 16641997 NA VGLL3 -1 Transcription cofactor vestigial-like protein 3 Vgl-3 gene 1291 0.0882021116002911 FUT3 F - Protein Fate membrane IDA integral to membrane IEA oligosaccharide biosynthetic process IDA cell-cell recognition IC protein amino acid glycosylation IEA biopolymer glycosylation IDA 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity IEA alpha(1,3)-fucosyltransferase activity IDA Galactoside 3(4)-L-fucosyltransferase; 2.4.1.65; Blood group Lewis alpha-4-fucosyltransferase; Lewis FT; Fucosyltransferase 3; Fucosyltransferase III; FucT-III 15057824 15489334 1977660 7650030 7961897 8063716 8219240 8240322 8240337 8801770 9268337 9703429 NA FUT3 1 Galactoside 3(4)-L-fucosyltransferase 2.4.1.65 Blood group Lewis alpha-4-fucosyltransferase Lewis FT Fucosyltransferase 3 Fucosyltransferase III FucT-III gene 1291 0.47015555163257 FUT1 F - Protein Fate Golgi apparatus TAS integral to plasma membrane TAS L-fucose catabolic process NAS protein amino acid glycosylation TAS galactoside 2-alpha-L-fucosyltransferase activity TAS Galactoside 2-alpha-L-fucosyltransferase 1; 2.4.1.69; Alpha(1,2)FT 1; Blood group H alpha 2-fucosyltransferase; Fucosyltransferase 1; GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1 15489334 2118655 7912436 9122901 9226185 9299444 NA FUT1 -1 Galactoside 2-alpha-L-fucosyltransferase 1 2.4.1.69 Alpha(1,2)FT 1 Blood group H alpha 2-fucosyltransferase Fucosyltransferase 1 GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1 gene 1291 0.0126331677876299 SYNE1 C - Cellular Fate and Organization nuclear outer membrane IEA nuclear membrane IDA Golgi apparatus IDA postsynaptic membrane IDA integral to membrane IDA cytoskeleton IEA sarcomere IDA muscle cell differentiation IDA cell death IEA Golgi organization and biogenesis IDA actin binding IDA protein homodimerization activity ISS Nesprin-1; Enaptin; Myocyte nuclear envelope protein 1; Myne-1; Nuclear envelope spectrin repeat protein 1; Synaptic nuclear envelope protein 1; Syne-1 10574462 11214970 11792814 11801724 12163176 12168954 12408964 12808039 14574404 14702039 15093733 16959974 17081983 17159980 17761684 17974005 18396275 19690332 21269460 22518138 9872452 NA SYNE1 -1 Nesprin-1 Enaptin Myocyte nuclear envelope protein 1 Myne-1 Nuclear envelope spectrin repeat protein 1 Synaptic nuclear envelope protein 1 Syne-1 gene 1291 0.443742622063426 C - Cellular Fate and Organization integral to plasma membrane TAS integral to membrane IEA cell surface receptor linked signal transduction TAS Signal-regulatory protein beta-1 isoform 3; SIRP-beta-1 isoform 3; Precursor 10604985 10940905 11780052 14702039 15489334 16081415 16335952 18657508 9062191 11780052 14702039 17974005 18657508 NA SIRBL -1 Signal-regulatory protein beta-1 isoform 3 SIRP-beta-1 isoform 3 Precursor gene 1291 0.182533419955059 DCHS1 C - Cellular Fate and Organization plasma membrane IEA membrane NAS integral to membrane IEA calcium-dependent cell-cell adhesion NAS homophilic cell adhesion IEA calcium ion binding IEA Protocadherin-16; Cadherin-19; Cadherin-25; Fibroblast cadherin-1; Protein dachsous homolog 1; Precursor 11597768 16959974 9199196 NA PCD16 -1 Protocadherin-16 Cadherin-19 Cadherin-25 Fibroblast cadherin-1 Protein dachsous homolog 1 Precursor gene 1485 0.00116321476413408 ADAR T - Transcription cytoplasm IDA nucleolus IEA nucleus IDA nucleoplasm TAS mRNA processing IEA negative regulation of apoptosis IEA defense response to virus IEA mRNA modification TAS protein export from nucleus IDA RNA-mediated gene silencing IEA protein import into nucleus IDA response to virus IMP adenosine to inosine editing IDA positive regulation of viral genome replication IDA double-stranded RNA binding IEA double-stranded RNA adenosine deaminase activity NAS DNA binding IEA metal ion binding IEA Double-stranded RNA-specific adenosine deaminase; DRADA; 3.5.4.-; 136 kDa double-stranded RNA-binding protein; p136; Interferon-inducible protein 4; IFI-4; K88DSRBP 10200312 10364558 10535945 12618436 12665561 12916015 15146470 15489334 15556947 15659327 15858013 16055709 16120648 16475990 16710414 16959974 16964243 17079286 17924679 17974005 18178553 18220336 18362360 18669648 19124606 19605474 19651874 19690332 19710021 19908260 20068231 20192758 21182352 21211811 21269460 21289159 21406692 21490091 21769729 22022963 22113393 22278222 22988838 7565688 7972084 9020165 NA DSRAD 1 Double-stranded RNA-specific adenosine deaminase DRADA 3.5.4.- 136 kDa double-stranded RNA-binding protein p136 Interferon-inducible protein 4 IFI-4 K88DSRBP gene 1291 0.0278647230913388 Uncharacterized protein C1orf109 14702039 15489334 NA CA109 1 Uncharacterized protein C1orf109 gene 1889 1.0 MYCN C - Cellular Fate and Organization nucleus IDA chromatin TAS negative regulation of astrocyte differentiation IEA regulation of transcription from RNA polymerase II promoter TAS lung development IEA cartilage condensation IEA positive regulation of transcription from RNA polymerase II promoter IEA embryonic skeletal morphogenesis IEA positive regulation of mesenchymal cell proliferation IEA branching morphogenesis of a tube IEA embryonic digit morphogenesis IEA transcription factor activity TAS DNA binding TAS N-myc proto-oncogene protein; Class E basic helix-loop-helix protein 37; bHLHe37 1425701 15489334 15821734 16906565 17311883 18488021 2834684 2869488 2987858 3008339 3437890 3510398 NA MYCN 0 N-myc proto-oncogene protein Class E basic helix-loop-helix protein 37 bHLHe37 TF 84395 1.55152589626848E-4 novel 1 mir 1291 0.018030555180901 T - Transcription heterochromatin IEA PRC1 complex ISS nuclear chromatin IDA negative regulation of transcription from RNA polymerase II promoter IMP transcription, DNA-dependent IEA chromatin modification IEA single-stranded RNA binding IEA Chromobox protein homolog 7 10591208 14647293 15489334 19636380 19791798 20696397 21047797 21060834 21282530 NA CBX7 -1 Chromobox protein homolog 7 gene 1291 0.0750711142623216 F - Protein Fate cytoplasm IDA plasma membrane IDA nucleus IDA proteolysis TAS aminopeptidase activity IEA zinc ion binding IEA dipeptidyl-peptidase activity TAS metallopeptidase activity IEA Dipeptidyl peptidase 3; 3.4.14.4; Dipeptidyl aminopeptidase III; Dipeptidyl arylamidase III; Dipeptidyl peptidase III; DPP III 11209758 14702039 14759258 15489334 16554811 21269460 9425109 NA DPP3 1 Dipeptidyl peptidase 3 3.4.14.4 Dipeptidyl aminopeptidase III Dipeptidyl arylamidase III Dipeptidyl peptidase III DPP III gene 1291 9.22127029133089E-4 Uncharacterized protein C1orf106 14702039 15489334 16710414 NA CA106 1 Uncharacterized protein C1orf106 gene 1291 0.0714360801321983 TNNC1 N - Not Matched troponin complex IDA cytosol TAS muscle filament sliding TAS ventricular cardiac muscle morphogenesis IMP regulation of ATPase activity ISS troponin I binding IDA actin filament binding ISS calcium ion binding IDA protein homodimerization activity IDA Troponin C, slow skeletal and cardiac muscles; TN-C 11385718 12732641 15489334 15542288 16302972 18572189 19439414 2250022 3166492 3951483 9219516 9315850 NA TNNC1 -1 Troponin C, slow skeletal and cardiac muscles TN-C gene 1291 0.0849340188103281 D - Genome Maintenance nuclear euchromatin IDA spindle IDA nuclear inner membrane NAS condensed chromosome, pericentric region ISS nuclear centric heterochromatin ISS chromatin remodeling NAS negative regulation of transcription, DNA-dependent IDA transcription, DNA-dependent IEA Chromobox protein homolog 3; HECH; Heterochromatin protein 1 homolog gamma; HP1 gamma; Modifier 2 protein 10330177 10460410 10664448 11242053 12004135 15489334 15502821 16964243 17081983 18318008 18669648 18691976 19608861 19880879 20068231 20562864 20850016 21269460 21406692 8663349 9169472 9636146 9864353 NA CBX3 1 Chromobox protein homolog 3 HECH Heterochromatin protein 1 homolog gamma HP1 gamma Modifier 2 protein gene 1291 0.0958343609500199 NPNT C - Cellular Fate and Organization membrane IEA extracellular matrix (sensu Metazoa) ISS basement membrane IEA smooth muscle contractile fiber IEA positive regulation of osteoblast differentiation IEA ureteric bud branching IEA cell-matrix adhesion IEA extracellular matrix organization and biogenesis IEA positive regulation of smooth muscle contraction IEA cell differentiation IEA positive regulation of transforming growth factor beta receptor signaling pathway IEA establishment of protein localization IEA integrin binding ISS calcium ion binding IEA Nephronectin; Preosteoblast EGF-like repeat protein with MAM domain; Protein EGFL6-like; Precursor 12975309 14702039 15754038 15815621 NA NPNT -1 Nephronectin Preosteoblast EGF-like repeat protein with MAM domain Protein EGFL6-like Precursor gene 1291 0.0684467560661034 F - Protein Fate plasma membrane IDA integral to membrane IEA proteolysis IEA serine-type endopeptidase activity IDA Rhomboid-related protein 2; RRP2; 3.4.21.105; Rhomboid-like protein 2; Rhomboid-related protein 2, N-terminal fragment; NTF; Rhomboid-related protein 2, C-terminal fragment; CTF 11672525 14702039 15047175 15489334 16710414 19850051 NA RHBL2 1 Rhomboid-related protein 2 RRP2 3.4.21.105 Rhomboid-like protein 2 Rhomboid-related protein 2, N-terminal fragment NTF Rhomboid-related protein 2, C-terminal fragment CTF gene 42470 0.238122143568515 novel 1 mir 13775 0.309532302208021 novel 1 mir 1291 0.0136131056747202 KDM1A C - Cellular Fate and Organization transcription factor complex ISS nuclear chromatin IDA negative regulation of protein binding IMP negative regulation of apoptosis IMP cell proliferation IEA pituitary gland development IEA negative regulation of transcription from RNA polymerase II promoter IMP embryonic development (sensu Mammalia) IEA transcription, DNA-dependent IEA negative regulation of transcription factor activity IDA negative regulation of DNA binding IC positive regulation of transcription factor activity IDA positive regulation of megakaryocyte differentiation IEA blood coagulation TAS positive regulation of erythrocyte differentiation IEA positive regulation of transcription from RNA polymerase II promoter IDA positive regulation of hormone biosynthetic process IEA negative regulation of histone H3-K9 methylation IEA negative regulation of histone H3-K4 methylation IEA negative regulation of DNA damage response, signal transduction by p53 class mediator IMP granulocyte differentiation IEA muscle cell development ISS histone demethylase activity (H3-K9 specific) IDA transcription factor activity IEA ligand-dependent nuclear receptor transcription coactivator activity IMP chromatin binding IDA FAD binding IDA oxidoreductase activity IDA MRF binding IDA androgen receptor binding IDA Lysine-specific histone demethylase 1A; 1.-.-.-; BRAF35-HDAC complex protein BHC110; Flavin-containing amine oxidase domain-containing protein 2 11102443 12032298 12493763 15489334 15620353 15811342 16079794 16079795 16140033 16223729 16531230 16710414 16885027 16956976 17081983 17805299 17974005 18220336 18669648 18691976 19369195 19690332 19880879 20068231 20228790 20562920 21269460 21406692 9628581 NA KDM1A 1 Lysine-specific histone demethylase 1A 1.-.-.- BRAF35-HDAC complex protein BHC110 Flavin-containing amine oxidase domain-containing protein 2 gene 1625 0.0050181180805082 ZHX3 C - Cellular Fate and Organization cytoplasm IDA nucleolus IDA positive regulation of osteoblast differentiation IMP negative regulation of transcription from RNA polymerase II promoter IEA negative regulation of transcription, DNA-dependent IDA transcription, DNA-dependent IEA cell differentiation IEA sequence-specific DNA binding IEA transcription factor activity IDA protein heterodimerization activity IDA transcription corepressor activity IEA zinc ion binding IEA protein homodimerization activity IDA Zinc fingers and homeoboxes protein 3; Triple homeobox protein 1; Zinc finger and homeodomain protein 3 11780052 12168954 12659632 18669648 19690332 20068231 21174497 9455477 NA ZHX3 -1 Zinc fingers and homeoboxes protein 3 Triple homeobox protein 1 Zinc finger and homeodomain protein 3 gene 1291 9.22127029133089E-4 PRDX2 C - Cellular Fate and Organization cytoplasm TAS cytosol IEA negative regulation of apoptosis TAS negative regulation of neuron apoptosis IEA removal of superoxide radicals IDA hydrogen peroxide catabolic process TAS thioredoxin peroxidase activity IDA Peroxiredoxin-2; 1.11.1.15; Natural killer cell-enhancing factor B; NKEF-B; PRP; Thiol-specific antioxidant protein; TSA; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1 10873855 11904290 12853451 1286667 14702039 15057824 15489334 17141802 21269460 8026862 8144038 8313871 8554614 9150948 NA PRDX2 1 Peroxiredoxin-2 1.11.1.15 Natural killer cell-enhancing factor B NKEF-B PRP Thiol-specific antioxidant protein TSA Thioredoxin peroxidase 1 Thioredoxin-dependent peroxide reductase 1 gene 1291 0.272713668154894 C - Cellular Fate and Organization intermediate filament TAS sarcolemma IEA Z disc IEA dystrophin-associated glycoprotein complex IEA costamere IDA response to estrogen stimulus IEP virus-host interaction IEA sarcomere organization IDA structural constituent of cytoskeleton TAS structural constituent of muscle IDA Keratin, type I cytoskeletal 19; Cytokeratin-19; CK-19; Keratin-19; K19 10212274 10623642 10809736 11682035 1286667 14702039 15489334 16000376 16625196 21049038 21269460 2447559 2448790 2468493 2469734 NA K1C19 1 Keratin, type I cytoskeletal 19 Cytokeratin-19 CK-19 Keratin-19 K19 gene 1291 0.00955317868538724 NT5E R - Stress and Defence cytoplasm IDA plasma membrane IDA anchored to membrane IEA AMP catabolic process IEA purine nucleotide catabolic process TAS pyrimidine nucleoside catabolic process TAS purine base metabolic process TAS negative regulation of inflammatory response IEA DNA metabolic process TAS adenosine biosynthetic process IEA pyrimidine base metabolic process TAS nucleotide binding IEA 5'-nucleotidase activity EXP metal ion binding IEA 5'-nucleotidase; 5'-NT; 3.1.3.5; Ecto-5'-nucleotidase; CD73; Precursor 14574404 16303743 19159218 19349973 21288095 2129526 2173922 8566797 NA 5NTD 1 5'-nucleotidase 5'-NT 3.1.3.5 Ecto-5'-nucleotidase CD73 Precursor gene 1291 0.00275312073119889 CKS1B D - Genome Maintenance nucleoplasm TAS S phase of mitotic cell cycle TAS G1/S transition of mitotic cell cycle TAS cell proliferation TAS regulation of cyclin-dependent protein kinase activity TAS G1 phase of mitotic cell cycle TAS cell division IEA cyclin-dependent protein kinase regulator activity IEA Cyclin-dependent kinases regulatory subunit 1; CKS-1 15489334 21269460 2227411 7791211 8601310 NA CKS1 1 Cyclin-dependent kinases regulatory subunit 1 CKS-1 gene 1291 0.0914604721306057 RAD51AP1 D - Genome Maintenance nucleus IC double-strand break repair via homologous recombination NAS double-stranded DNA binding IDA single-stranded DNA binding IDA RNA binding IDA RAD51-associated protein 1; RAD51-interacting protein 14702039 15489334 16990250 18669648 20068231 20871616 21269460 21406692 9396801 NA R51A1 1 RAD51-associated protein 1 RAD51-interacting protein gene 1291 4.58870887597033E-4 PPP4C D - Genome Maintenance protein phosphatase 4 complex IEA cytoplasm IDA centrosome NAS plasma membrane IDA nucleus NAS microtubule cytoskeleton organization and biogenesis NAS NF-kappaB-inducing kinase activity NAS protein serine/threonine phosphatase activity IDA metal ion binding NAS Serine/threonine-protein phosphatase 4 catalytic subunit; PP4C; Pp4; 3.1.3.16; Protein phosphatase X; PP-X 11698396 12668731 12934076 1336397 15331607 15489334 15805470 16085932 18347064 18487071 18614045 18715871 18758438 20154705 21269460 9837938 NA PP4C 1 Serine/threonine-protein phosphatase 4 catalytic subunit PP4C Pp4 3.1.3.16 Protein phosphatase X PP-X gene 4393 0.201233002005417 SPOCK2 C - Cellular Fate and Organization extracellular matrix (sensu Metazoa) NAS signal transduction IEA peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan IEA extracellular matrix organization and biogenesis NAS regulation of cell differentiation NAS synaptogenesis NAS calcium ion binding IDA extracellular matrix binding IEA glycosaminoglycan binding IEA Testican-2; SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2; Precursor 10386950 12975309 14702039 15164054 15340161 15489334 9039502 NA TICN2 -1 Testican-2 SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2 Precursor gene 1291 0.00190723864225319 CCNB1 D - Genome Maintenance spindle pole IDA centrosome IDA outer kinetochore of condensed nuclear chromosome IDA membrane IEA nucleoplasm TAS cytosol TAS mitotic prometaphase IDA positive regulation of attachment of spindle microtubules to kinetochore IMP response to drug IEA mitotic spindle stabilization IMP response to DDT IEA positive regulation of ubiquitin ligase activity during mitotic cell cycle TAS gut development IEA regulation of cyclin-dependent protein kinase activity IEA oocyte maturation IEA spermatogenesis IEA tissue regeneration IEA anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS embryonic development (sensu Mammalia) IEA response to mechanical stimulus IEA positive regulation of progression through mitotic cell cycle IMP G1/S transition of mitotic cell cycle TAS protein complex assembly IEA G2/M transition of mitotic cell cycle NAS ventricular cardiac muscle cell development IEA negative regulation of protein amino acid phosphorylation IEA protein amino acid phosphorylation IEA mitotic metaphase plate congression IMP positive regulation of mRNA 3'-end processing IEA cell division IEA kinase activity IEA G2/mitotic-specific cyclin-B1 10716937 12447691 12524548 12612082 12775724 15181148 15489334 16009132 17495531 17495533 18691976 19608861 21269460 2570636 7843284 NA CCNB1 1 G2/mitotic-specific cyclin-B1 gene 1291 0.0035102842708369 PXDC1 N - Not Matched cell communication IEA phosphoinositide binding IEA PX domain-containing protein 1 14574404 14702039 15489334 16959974 17974005 NA PXDC1 -1 PX domain-containing protein 1 gene 1291 0.134169009163847 PLEKHH2 C - Cellular Fate and Organization plasma membrane IDA integral to membrane IEA cortical actin cytoskeleton ISS lamellipodium IDA negative regulation of actin filament depolymerization ISS phospholipid binding IEA actin binding ISS Pleckstrin homology domain-containing family H member 2 15489334 17974005 22832517 NA PKHH2 -1 Pleckstrin homology domain-containing family H member 2 gene 1291 0.00458201074186734 N - Not Matched mitochondrion IEA integral to membrane IEA negative regulation of cell migration IEA metabolic process IEA acylglycerol lipase activity IEA Monoacylglycerol lipase ABHD6; 3.1.1.23; 2-arachidonoylglycerol hydrolase; Abhydrolase domain-containing protein 6 14702039 15489334 16641997 NA ABHD6 -1 Monoacylglycerol lipase ABHD6 3.1.1.23 2-arachidonoylglycerol hydrolase Abhydrolase domain-containing protein 6 gene 1291 5.92958462028696E-4 MTMR9 N - Not Matched cytoplasm IEA phosphoric monoester hydrolase activity IEA enzyme regulator activity IEA Myotubularin-related protein 9 11472061 14702039 15489334 16787938 18669648 19690332 20068231 21269460 21406692 NA MTMR9 -1 Myotubularin-related protein 9 gene 1638 1.0 C - Cellular Fate and Organization nucleus IDA skeletal development TAS positive regulation of transcription from RNA polymerase II promoter IEA positive regulation of transcription, DNA-dependent IDA transcription factor activity IDA DNA binding TAS Protein C-ets-2 10830953 14702039 15489334 18691976 2250910 2847145 2997781 NA ETS2 0 Protein C-ets-2 TF 4781 1.0 ETS1 D - Genome Maintenance transcription factor complex IEA nucleus IDA response to hypoxia IEA pregnancy IEA positive regulation of cell proliferation IEA negative regulation of cell proliferation TAS positive regulation of cell migration IEA transcription from RNA polymerase II promoter IDA pituitary gland development IEA induction of apoptosis IDA negative regulation of progression through cell cycle IDA hypothalamus development IEA positive regulation of angiogenesis IEA transcription, DNA-dependent IEA response to mechanical stimulus IEA immune response TAS PML body organization and biogenesis IDA positive regulation of erythrocyte differentiation IDA positive regulation of transcription from RNA polymerase II promoter IDA cell motility involved in cell locomotion IMP positive regulation of transcription, DNA-dependent IDA response to estradiol stimulus IEA positive regulation of cell motility IMP response to antibiotic IDA sequence-specific DNA binding IEA transcription factor activity IDA DNA binding ISS transcription factor binding NAS Protein C-ets-1; p54 10698492 15592455 1614856 16554811 17974005 18566588 19377509 19608861 19690332 20378371 2847145 2997781 3060801 8231246 8521493 9333025 NA ETS1 0 Protein C-ets-1 p54 TF 1616 0.00224379899444303 C - Cellular Fate and Organization nuclear envelope IEA cytosol TAS phosphatidylinositol biosynthetic process TAS protein serine/threonine phosphatase activity NAS calcium-activated potassium channel activity IDA protein tyrosine phosphatase activity NAS Myotubularin-related protein 6; 3.1.3.- 12890864 14702039 15057823 15489334 15831468 16787938 16847315 17974005 18669648 9736772 NA MTMR6 -1 Myotubularin-related protein 6 3.1.3.- gene 1291 0.00118778412475103 PRKCQ C - Cellular Fate and Organization immunological synapse IEA plasma membrane TAS cytosol TAS T cell receptor signaling pathway TAS positive regulation of interleukin-17 production ISS positive regulation of interleukin-4 production ISS negative regulation of insulin receptor signaling pathway IMP platelet activation TAS regulation of cell growth NAS cell structure disassembly during apoptosis TAS positive regulation of interleukin-2 biosynthetic process IEA inflammatory response IEA activation of NF-kappaB transcription factor IDA axon guidance TAS positive regulation of T cell proliferation IEA membrane protein ectodomain proteolysis ISS protein serine/threonine kinase activity NAS protein kinase C activity IEA ATP binding NAS metal ion binding IEA Protein kinase C theta type; 2.7.11.13; nPKC-theta 10636891 10652356 11342610 11772397 11861617 12473184 14988727 15164054 15254234 15282562 15364919 15364937 15489334 16252004 16356855 16709830 16978534 17344846 17544292 18328786 18691976 19369195 19549985 19690332 21269460 21406692 21944869 7686153 7983077 8444877 8657160 NA KPCT -1 Protein kinase C theta type 2.7.11.13 nPKC-theta gene 1291 0.00758653205488051 TOX3 T - Transcription nucleus IEA negative regulation of neuron apoptosis IDA apoptosis IEA positive regulation of transcription, DNA-dependent IDA transcription, DNA-dependent IEA chromatin binding IDA protein homodimerization activity IDA TOX high mobility group box family member 3; CAG trinucleotide repeat-containing gene F9 protein; Trinucleotide repeat-containing gene 9 protein 14702039 15616553 21172805 9225980 NA TOX3 1 TOX high mobility group box family member 3 CAG trinucleotide repeat-containing gene F9 protein Trinucleotide repeat-containing gene 9 protein gene 1291 0.0491364547454246 CALD1 C - Cellular Fate and Organization plasma membrane IDA actin cap IEA actin cytoskeleton IDA myofibril IEA cytosol TAS muscle contraction TAS cell motility TAS calmodulin binding TAS actin binding TAS tropomyosin binding TAS Caldesmon; CDM 12853948 1465449 14702039 15489334 1555769 17081983 17924679 18669648 1885618 20068231 21269460 21406692 8227296 NA CALD1 -1 Caldesmon CDM gene 2318 7.69044721408744E-4 CYBB A - Transport and Sensing mitochondrion IEA phagocytic vesicle membrane TAS NADPH oxidase complex IDA respiratory burst IMP superoxide release IDA inflammatory response TAS interaction with host TAS innate immune response IMP antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS hydrogen peroxide biosynthetic process IEA voltage-gated ion channel activity IEA superoxide-generating NADPH oxidase activity TAS FAD binding IMP metal ion binding IEA heme binding IMP Cytochrome b-245 heavy chain; 1.-.-.-; CGD91-phox; Cytochrome b(558) subunit beta; Cytochrome b558 subunit beta; Heme-binding membrane glycoprotein gp91phox; NADPH oxidase 2; Neutrophil cytochrome b 91 kDa polypeptide; Superoxide-generating NADPH oxidase heavy chain subunit; gp91-1; gp91-phox; p22 phagocyte B-cytochrome 10089913 10578014 10914676 11462241 11997083 12139950 14702039 15338276 15489334 1710153 18773283 19159218 21278736 22125116 2425263 2556453 3600768 3600769 7927345 8101486 8182143 8916969 9111587 9585602 9667376 9790760 9794433 9856476 9888386 NA CY24B 1 Cytochrome b-245 heavy chain 1.-.-.- CGD91-phox Cytochrome b(558) subunit beta Cytochrome b558 subunit beta Heme-binding membrane glycoprotein gp91phox NADPH oxidase 2 Neutrophil cytochrome b 91 kDa polypeptide Superoxide-generating NADPH oxidase heavy chain subunit gp91-1 gp91-phox p22 phagocyte B-cytochrome gene 1291 0.122303416601617 PRKCH C - Cellular Fate and Organization plasma membrane IDA cytosol ISS signal transduction TAS positive regulation of keratinocyte differentiation ISS activation of NF-kappaB transcription factor IMP platelet activation TAS positive regulation of B cell receptor signaling pathway IMP calcium-independent protein kinase C activity IEA protein kinase C activity TAS ATP binding IEA metal ion binding IEA Protein kinase C eta type; 2.7.11.13; PKC-L; nPKC-eta 10806212 11112424 11772428 12473186 12508121 14702039 1545821 15489334 15489897 15632189 16973127 17146445 17206144 17344846 18780722 19114660 1986216 20558593 21820409 7988719 NA KPCL -1 Protein kinase C eta type 2.7.11.13 PKC-L nPKC-eta gene 1291 0.0105262313493477 C3orf14 Uncharacterized protein C3orf14 10931946 14702039 15489334 NA CC014 1 Uncharacterized protein C3orf14 gene 1291 0.0409712296333968 PRKCE D - Genome Maintenance mitochondrion IEA perinuclear region ISS Golgi apparatus IEA plasma membrane IDA endoplasmic reticulum IDA nucleus IEA cytoskeleton IEA cytosol IDA positive regulation of lipid catabolic process IEA nerve growth factor receptor signaling pathway TAS release of sequestered calcium ion into cytosol IEA regulation of peptidyl-tyrosine phosphorylation IEA platelet activation TAS response to morphine IEA induction of apoptosis TAS phospholipase C activation TAS positive regulation of synaptic transmission, GABAergic IEA cell cycle IEA epidermal growth factor receptor signaling pathway TAS positive regulation of actin filament polymerization ISS fibroblast growth factor receptor signaling pathway TAS macrophage activation during immune response IEA positive regulation of insulin secretion IEA positive regulation of I-kappaB kinase/NF-kappaB cascade IEA cell adhesion IEA positive regulation of MAPKKK cascade IEA lipopolysaccharide-mediated signaling pathway ISS cell division IEA actin monomer binding ISS calcium-independent protein kinase C activity IEA ethanol binding IEA receptor activator activity IEA protein kinase C activity IDA signal transducer activity TAS enzyme activator activity IMP ATP binding IEA metal ion binding IEA Protein kinase C epsilon type; 2.7.11.13; nPKC-epsilon 11884385 11964154 12473185 1374067 1382605 15355962 15489334 15632189 15815621 16584980 16757566 16959974 17344846 17603037 17875639 17875724 18637120 18637121 18669648 18691976 19662078 20350291 21681677 21810427 NA KPCE -1 Protein kinase C epsilon type 2.7.11.13 nPKC-epsilon gene 1291 0.0021046852814931 ERAL1 P - Translation mitochondrial matrix IDA mitochondrial inner membrane IEA ribosomal small subunit assembly and maintenance IMP rRNA binding IDA ribosomal small subunit binding IDA GTP binding NAS GTPase Era, mitochondrial; H-ERA; hERA; Conserved ERA-like GTPase; CEGA; ERA-W; ERA-like protein 1; Precursor 10945472 11733036 14702039 14759258 15489334 16625196 20068231 20430825 20604745 21269460 NA ERAL1 1 GTPase Era, mitochondrial H-ERA hERA Conserved ERA-like GTPase CEGA ERA-W ERA-like protein 1 Precursor gene 1921 0.175841204030756 NPM1 D - Genome Maintenance cytoplasm IDA ribonucleoprotein complex IDA nucleolus IDA nucleoplasm IDA spindle pole centrosome IDA negative regulation of apoptosis NAS negative regulation of cell proliferation IMP centrosome cycle IMP ribosome assembly TAS cell aging IMP regulation of endodeoxyribonuclease activity IDA regulation of centriole replication IMP protein oligomerization IDA intracellular protein transport TAS nucleocytoplasmic transport IDA signal transduction NAS DNA repair IDA activation of NF-kappaB transcription factor IMP virus-host interaction IEA histone binding IDA protein heterodimerization activity IMP NF-kappaB binding IDA RNA binding IDA transcription coactivator activity IDA ribosomal large subunit binding IDA ribosomal small subunit binding IDA unfolded protein binding IDA Tat protein binding IDA protein homodimerization activity IDA Nucleophosmin; NPM; Nucleolar phosphoprotein B23; Nucleolar protein NO38; Numatrin 11051553 11309377 12058066 12214246 12429849 14702039 15190079 15388344 15489334 15659725 15772089 15897463 16107701 16574551 16916647 17015463 17081983 17215513 17879352 17924679 18024471 18220336 18259216 18318008 18511415 18669648 18691976 18809582 19015314 19054851 19188445 19369195 19608861 19690332 20068231 20159986 20333249 20352051 21084279 21269460 21406692 22002061 2429957 2478125 2602120 2713355 2775293 3944116 7631008 8122112 8314759 8562957 8570204 8633037 9092633 9150948 NA NPM 1 Nucleophosmin NPM Nucleolar phosphoprotein B23 Nucleolar protein NO38 Numatrin gene 1291 1.0 TFEB T - Transcription transcription factor complex IEA cytoplasm IDA nucleus IDA positive regulation of transcription from RNA polymerase II promoter IDA humoral immune response ISS embryonic placenta development ISS transcription, DNA-dependent IEA transcription factor activity IDA Transcription factor EB; Class E basic helix-loop-helix protein 35; bHLHe35 14574404 15118077 15489334 15507434 1748288 18669648 19556463 19690332 20068231 2115126 NA TFEB 0 Transcription factor EB Class E basic helix-loop-helix protein 35 bHLHe35 TF 1291 0.00190723864225319 LYPLA2 N - Not Matched cytoplasm IEA fatty acid metabolic process IEA hydrolase activity IEA Acyl-protein thioesterase 2; APT-2; 3.1.2.-; Lysophospholipase II; LPL-II; LysoPLA II 15489334 16710414 21152083 21269460 NA LYPA2 1 Acyl-protein thioesterase 2 APT-2 3.1.2.- Lysophospholipase II LPL-II LysoPLA II gene 1291 0.00556456523555154 GAPVD1 C - Cellular Fate and Organization membrane IEA endosome IEA cytosol IDA positive regulation of GTPase activity IEA signal transduction IEA regulation of small GTPase mediated signal transduction IEA endocytosis IEA regulation of protein transport IMP guanyl-nucleotide exchange factor activity IMP GTPase activating protein binding IMP GTPase activator activity IEA GTPase-activating protein and VPS9 domain-containing protein 1; GAPex-5; Rab5-activating protein 6 10819331 12168954 14702039 15164053 15489334 16410077 16964243 17525332 17974005 18220336 18669648 18691976 19690332 20068231 21269460 21406692 NA GAPD1 -1 GTPase-activating protein and VPS9 domain-containing protein 1 GAPex-5 Rab5-activating protein 6 gene 1291 0.107607101424208 LYPLA1 N - Not Matched mitochondrion IEA cytosol TAS regulation of nitric-oxide synthase activity TAS fatty acid metabolic process IEA nitric oxide metabolic process TAS palmitoyl-(protein) hydrolase activity IMP lysophospholipase activity TAS Acyl-protein thioesterase 1; APT-1; hAPT1; 3.1.2.-; Lysophospholipase 1; Lysophospholipase I; LPL-I; LysoPLA I 11042152 11080636 15489334 20418879 21269460 NA LYPA1 1 Acyl-protein thioesterase 1 APT-1 hAPT1 3.1.2.- Lysophospholipase 1 Lysophospholipase I LPL-I LysoPLA I gene 1291 2.70321713234621E-5 M - Other Metabolism cytoplasmic vesicle IEA integral to membrane IEA lysosomal membrane IEA response to pH IEA antiporter activity IEA voltage-gated chloride channel activity IEA chloride channel activity TAS ATP binding IEA H(+)/Cl(-) exchange transporter 7; Chloride channel 7 alpha subunit; Chloride channel protein 7; ClC-7 11207362 11741829 14584882 14702039 15489334 15616553 17033731 17081983 17897319 18449189 18669648 19690332 19953639 21406692 21527911 8543009 9565675 NA CLCN7 1 H(+)/Cl(-) exchange transporter 7 Chloride channel 7 alpha subunit Chloride channel protein 7 ClC-7 gene 2403 1.58993537789209E-4 T - Transcription CCAAT-binding factor complex IDA transcription from RNA polymerase II promoter TAS positive regulation of transcription from RNA polymerase II promoter IEA transcription factor activity TAS DNA binding IDA Nuclear transcription factor Y subunit alpha; CAAT box DNA-binding protein subunit A; Nuclear transcription factor Y subunit A; NF-YA 10441475 10571058 12659632 12741956 14574404 15489334 1549471 18669648 19302979 2000400 NA NFYA 1 Nuclear transcription factor Y subunit alpha CAAT box DNA-binding protein subunit A Nuclear transcription factor Y subunit A NF-YA TF 1291 4.53647777058396E-4 N4BP2L1 NEDD4-binding protein 2-like 1 15057823 15489334 NA N42L1 -1 NEDD4-binding protein 2-like 1 gene 1526 1.0 MYOD1 C - Cellular Fate and Organization transcription factor complex ISS nuclear chromatin ISS myofibril IEA myoblast cell fate determination IEA positive regulation of muscle cell differentiation IDA regulation of alternative nuclear mRNA splicing, via spliceosome IEA positive regulation of transcription from RNA polymerase II promoter ISS skeletal muscle fiber plasticity IEA skeletal muscle fiber development IEA positive regulation of skeletal muscle regeneration IEA regulation of RNA splicing IDA protein amino acid phosphorylation TAS cardiac muscle cell differentiation IEA muscle cell fate commitment ISS cellular response to starvation IEA protein heterodimerization activity ISS RNA polymerase II transcription factor activity, enhancer binding TAS transcription coactivator activity TAS Myoblast determination protein 1; Class C basic helix-loop-helix protein 1; bHLHc1; Myogenic factor 3; Myf-3 11532390 12037670 15489334 16858404 16959974 1850513 2583111 9546368 9774340 NA MYOD1 0 Myoblast determination protein 1 Class C basic helix-loop-helix protein 1 bHLHc1 Myogenic factor 3 Myf-3 TF 1291 0.0439244987968563 SNX2 A - Transport and Sensing early endosome membrane IEA endosome membrane IDA cell communication IEA intracellular protein transport IEA endocytosis TAS protein transporter activity IEA phosphoinositide binding IEA Sorting nexin-2; Transformation-related gene 9 protein; TRG-9 11438682 14596906 14702039 15489334 16179610 16964243 17101778 18669648 19608861 19690332 19935774 20068231 21269460 21406692 9819414 NA SNX2 -1 Sorting nexin-2 Transformation-related gene 9 protein TRG-9 gene 1291 0.110807554138766 DEPDC1 C - Cellular Fate and Organization transcriptional repressor complex IDA positive regulation of GTPase activity IEA negative regulation of transcription, DNA-dependent IDA transcription, DNA-dependent IEA GTPase activator activity IEA DEP domain-containing protein 1A 14702039 15489334 16710414 17452976 18669648 20587513 NA DEP1A 1 DEP domain-containing protein 1A gene 72350 3.5812260926079E-5 novel 1 mir 1291 0.220626047024778 MYOCD C - Cellular Fate and Organization nucleus IDA response to hypoxia IEP positive regulation of cell proliferation IEA negative regulation of cell proliferation IDA alveolus development IEA ventricular cardiac muscle cell differentiation IEA negative regulation of cyclin-dependent protein kinase activity IDA gut development IEA regulation of histone acetylation ISS negative regulation of transcription from RNA polymerase II promoter IEA regulation of myoblast differentiation IEA positive regulation of transcription factor activity IDA regulation of cell growth by extracellular stimulus IEA positive regulation of smooth muscle contraction IDA positive regulation of DNA binding IEA vasculogenesis IEA cardiac muscle cell differentiation ISS positive regulation of transforming growth factor beta receptor signaling pathway IEA transcription coactivator activity IEA protein domain specific binding IDA Myocardin 12397177 12640126 12920479 14702039 15489334 15907818 16054032 16625196 20385216 NA MYCD -1 Myocardin gene 1291 0.117179770282665 HDGF C - Cellular Fate and Organization cytoplasm TAS transcriptional repressor complex IDA extracellular space IDA cell proliferation TAS unfolded protein response, activation of signaling protein activity TAS nucleotide binding IEA DNA binding IEA heparin binding TAS Hepatoma-derived growth factor; HDGF; High mobility group protein 1-like 2; HMG-1L2 11751870 14702039 15302935 15489334 15491618 16710414 16807684 16964243 17081983 17270212 17487921 17974029 18088087 18318008 18331345 18669648 18691976 19367720 19369195 19608861 19690332 20068231 21269460 21406692 7929202 NA HDGF 1 Hepatoma-derived growth factor HDGF High mobility group protein 1-like 2 HMG-1L2 gene 1291 0.00128050315194328 HSPB11 C - Cellular Fate and Organization cilium IEA intraflagellar transport particle B IEA response to stress IEA cell adhesion IEA Heat shock protein beta-11; Hspb11; Placental protein 25; PP25 11042152 15489334 16710414 18816799 2018407 21269460 NA HSB11 -1 Heat shock protein beta-11 Hspb11 Placental protein 25 PP25 gene 1291 0.280751209954178 C - Cellular Fate and Organization positive regulation of alpha-beta T cell differentiation IEA signal transduction TAS MAPKKK cascade IEA positive regulation of Ras protein signal transduction IEA cell surface receptor linked signal transduction IEA positive thymic T cell selection IEA inositol trisphosphate 3-kinase activity TAS ATP binding IEA Inositol-trisphosphate 3-kinase B; 2.7.1.127; Inositol 1,4,5-trisphosphate 3-kinase B; IP3 3-kinase B; IP3K B; InsP 3-kinase B 11846419 15489334 1654894 16710414 18088087 18669648 19690332 NA IP3KB -1 Inositol-trisphosphate 3-kinase B 2.7.1.127 Inositol 1,4,5-trisphosphate 3-kinase B IP3 3-kinase B IP3K B InsP 3-kinase B gene 1584 0.0169618782683539 MEF2A C - Cellular Fate and Organization nuclear chromatin ISS nucleoplasm TAS mitochondrion distribution ISS nerve growth factor receptor signaling pathway TAS apoptosis IEA negative regulation of transcription from RNA polymerase II promoter IDA stress-activated MAPK cascade TAS dendrite morphogenesis ISS Toll signaling pathway TAS muscle development NAS positive regulation of muscle cell differentiation TAS MyD88-dependent toll-like receptor signaling pathway TAS innate immune response TAS ventricular cardiac myofibril development ISS mitochondrial genome maintenance ISS chromatin binding IEA RNA polymerase II transcription factor activity, enhancer binding IEA DNA binding IEA Myocyte-specific enhancer factor 2A; Serum response factor-like protein 1 10330143 10487761 10715212 10835359 10849446 11904443 12586839 12691662 14630949 14702039 1516833 15489334 15496429 15834131 15888658 15958500 16371476 16484498 16563226 16572171 1748287 17785444 18086930 18669648 18697823 19608861 21269460 9753748 9858528 NA MEF2A -1 Myocyte-specific enhancer factor 2A Serum response factor-like protein 1 TF 1291 0.00556253733701826 N - Not Matched cytosol TAS xenobiotic metabolic process IDA glutathione metabolic process IDA glutathione transferase activity IDA Glutathione S-transferase A4; 2.5.1.18; GST class-alpha member 4; Glutathione S-transferase A4-4 10329152 14574404 14702039 15489334 20085333 9461507 9480897 9587421 9820822 NA GSTA4 -1 Glutathione S-transferase A4 2.5.1.18 GST class-alpha member 4 Glutathione S-transferase A4-4 gene 1291 0.118412794759788 N - Not Matched mitochondrial outer membrane IEA integral to membrane TAS nucleotide binding IEA oxidoreductase activity IEA zinc ion binding IEA Synaptic vesicle membrane protein VAT-1 homolog; 1.-.-.- 12898150 14702039 15489334 16625196 16964243 17105775 18669648 19508442 20068231 21269460 7774926 8938427 NA VAT1 -1 Synaptic vesicle membrane protein VAT-1 homolog 1.-.-.- gene 1291 2.88755051520404E-5 FRMD4B N - Not Matched cytoplasm IEA cytoskeleton IEA ruffle IEA FERM domain-containing protein 4B; GRP1-binding protein GRSP1 10231032 14702039 15489334 16641997 18088087 NA FRM4B -1 FERM domain-containing protein 4B GRP1-binding protein GRSP1 gene 1291 1.53920060472355E-4 PAGR1 N - Not Matched histone methyltransferase complex IDA PAXIP1-associated glutamate-rich protein 1; PAXIP1-associated protein 1; PTIP-associated protein 1 15489334 15616553 17500065 NA PAGR1 1 PAXIP1-associated glutamate-rich protein 1 PAXIP1-associated protein 1 PTIP-associated protein 1 gene 1291 0.00685925996823963 NME4 C - Cellular Fate and Organization mitochondrial intermembrane space IEA mitochondrial inner membrane TAS UTP biosynthetic process IEA CTP biosynthetic process IEA GTP biosynthetic process IEA nucleobase, nucleoside and nucleotide interconversion TAS nucleoside metabolic process TAS nucleoside diphosphate kinase activity EXP ATP binding IEA metal ion binding IEA Nucleoside diphosphate kinase, mitochondrial; NDK; NDP kinase, mitochondrial; 2.7.4.6; Nucleoside diphosphate kinase D; NDPKD; nm23-H4; Precursor 10799505 11157797 15489334 15616553 9099850 NA NDKM 1 Nucleoside diphosphate kinase, mitochondrial NDK NDP kinase, mitochondrial 2.7.4.6 Nucleoside diphosphate kinase D NDPKD nm23-H4 Precursor gene 1291 0.00186355744930036 NME1 D - Genome Maintenance centrosome IEA perinuclear region IEA membrane IEA nucleus TAS cytosol TAS UTP biosynthetic process IEA CTP biosynthetic process IEA positive regulation of epithelial cell proliferation IMP GTP biosynthetic process IEA hippocampus development IEA negative regulation of cell proliferation TAS nucleobase, nucleoside and nucleotide interconversion TAS positive regulation of DNA binding IDA regulation of apoptosis TAS negative regulation of myeloid leukocyte differentiation IEA response to cAMP IEA endocytosis IEA deoxyribonuclease activity IDA magnesium ion binding IDA single-stranded DNA binding IEA nucleoside diphosphate kinase activity IDA GTP binding IDA ATP binding IDA Nucleoside diphosphate kinase A; NDK A; NDP kinase A; 2.7.4.6; Granzyme A-activated DNase; GAAD; Metastasis inhibition factor nm23; Tumor metastatic process-associated protein; nm23-H1 10512675 11835509 12601555 12628186 12972261 14702039 15489334 16442775 16625196 17906697 1851158 18781797 2056128 21269460 2509941 7916650 8047138 8270257 8810265 NA NDKA 1 Nucleoside diphosphate kinase A NDK A NDP kinase A 2.7.4.6 Granzyme A-activated DNase GAAD Metastasis inhibition factor nm23 Tumor metastatic process-associated protein nm23-H1 gene 1291 0.0347996146522839 TPSB2 F - Protein Fate extracellular region NAS proteolysis NAS serine-type endopeptidase activity NAS Tryptase beta-2; Tryptase-2; 3.4.21.59; Tryptase II; Precursor 10500112 14670919 15489334 15616553 18039527 19748655 2187193 2203827 8434231 9521329 9920877 NA TRYB2 -1 Tryptase beta-2 Tryptase-2 3.4.21.59 Tryptase II Precursor gene 1291 1.53920060472355E-4 BUB1B D - Genome Maintenance outer kinetochore of condensed chromosome IDA perinuclear region IDA microtubule organizing center IEA anaphase-promoting complex TAS condensed nuclear chromosome kinetochore IEA spindle midzone NAS cytosol TAS mitotic prometaphase TAS mitotic spindle checkpoint TAS cell proliferation TAS phosphoinositide-mediated signaling NAS apoptosis IEA spindle organization and biogenesis NAS negative regulation of ubiquitin ligase activity during mitotic cell cycle TAS mitotic metaphase/anaphase transition IEA anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS cell division IEA protein kinase activity NAS protein serine/threonine kinase activity IEA ATP binding IEA Mitotic checkpoint serine/threonine-protein kinase BUB1 beta; 2.7.11.1; MAD3/BUB1-related protein kinase; hBUBR1; Mitotic checkpoint kinase MAD3L; Protein SSK1 10366450 10477750 10593653 11702782 12925705 14702039 14706340 15020684 15475955 15489334 16227576 16411201 16760428 16964243 17344846 17376779 17785528 17981135 18374647 18669648 18691976 19015317 19407811 19411850 19503101 19625775 20068231 21269460 21406692 9521327 9618306 9660858 9763420 9889005 NA BUB1B 1 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta 2.7.11.1 MAD3/BUB1-related protein kinase hBUBR1 Mitotic checkpoint kinase MAD3L Protein SSK1 gene 1291 0.0714360801321983 MAPRE2 D - Genome Maintenance cytoplasm IEA microtubule IEA microtubule cytoskeleton IDA signal transduction TAS mitosis IEA cell proliferation TAS cell division IEA Microtubule-associated protein RP/EB family member 2; APC-binding protein EB2; End-binding protein 2; EB2 10188731 14514668 14702039 15489334 15592455 16177791 17081983 18088087 18669648 20068231 21269460 21406692 9233623 NA MARE2 -1 Microtubule-associated protein RP/EB family member 2 APC-binding protein EB2 End-binding protein 2 EB2 gene 1291 0.00224379899444303 C - Cellular Fate and Organization cell junction IEA plasma membrane IEA postsynaptic membrane IEA cell soma IEA postsynaptic density IEA calcium-dependent protein kinase inhibitor activity IEA Calcium/calmodulin-dependent protein kinase II inhibitor 1; CaMKII inhibitory protein alpha; CaMKIIN-alpha 16710414 18305109 NA CK2N1 -1 Calcium/calmodulin-dependent protein kinase II inhibitor 1 CaMKII inhibitory protein alpha CaMKIIN-alpha gene 1291 0.00896578061676545 KCNT2 M - Other Metabolism voltage-gated potassium channel complex IBA voltage-gated potassium channel activity IBA ATP binding IEA calcium-activated potassium channel activity IBA Potassium channel subfamily T member 2; Sequence like an intermediate conductance potassium channel subunit; Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1 14684870 14702039 15489334 16687497 16710414 16959974 17974005 NA KCNT2 -1 Potassium channel subfamily T member 2 Sequence like an intermediate conductance potassium channel subunit Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1 gene 1291 0.178836329879221 SUCO N - Not Matched rough endoplasmic reticulum ISS membrane ISS rough endoplasmic reticulum membrane IEA integral to membrane IEA positive regulation of osteoblast differentiation ISS regulation of bone remodeling ISS ossification IEA multicellular organismal development IEA SUN domain-containing ossification factor; Membrane protein CH1; Protein osteopotentia homolog; SUN-like protein 1; Precursor 10673381 11158380 15489334 16710414 18669648 NA SUCO 1 SUN domain-containing ossification factor Membrane protein CH1 Protein osteopotentia homolog SUN-like protein 1 Precursor gene 1291 0.245263346839975 SLC1A4 A - Transport and Sensing intermediate filament ISS melanosome IEA integral to plasma membrane IC cell soma IEA dendrite IEA cognition IMP synaptic transmission, glutamatergic NAS L-alanine transporter activity IDA L-proline transporter activity IDA L-threonine transporter activity IDA L-serine transporter activity IDA L-cystine transporter activity IDA L-glutamine transporter activity TAS sodium:dicarboxylate symporter activity IEA chloride channel activity IDA Neutral amino acid transporter A; Alanine/serine/cysteine/threonine transporter 1; ASCT-1; SATT; Solute carrier family 1 member 4 14702039 15489334 15815621 17081065 18669648 19349973 19690332 20068231 21269460 7896285 8101838 8340364 NA SATT 1 Neutral amino acid transporter A Alanine/serine/cysteine/threonine transporter 1 ASCT-1 SATT Solute carrier family 1 member 4 gene 1291 0.0599310847282657 RGL1 C - Cellular Fate and Organization cytosol TAS regulation of small GTPase mediated signal transduction IEA small GTPase mediated signal transduction NAS cellular lipid metabolic process TAS Ral guanyl-nucleotide exchange factor activity NAS Ral guanine nucleotide dissociation stimulator-like 1; RalGDS-like 1 10231032 10760592 15489334 16710414 16959974 17974005 NA RGL1 -1 Ral guanine nucleotide dissociation stimulator-like 1 RalGDS-like 1 gene 1291 1.26260240728011E-6 SLC1A1 A - Transport and Sensing integral to plasma membrane TAS L-glutamate import IDA synaptic transmission TAS protein homooligomerization IEA glutamate:sodium symporter activity IEA L-glutamate transporter activity TAS glutamate binding IEA sodium:dicarboxylate symporter activity IEA Excitatory amino acid transporter 3; Excitatory amino-acid carrier 1; Neuronal and epithelial glutamate transporter; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1 11317217 15164053 15489334 7521911 7859077 7914198 NA EAA3 -1 Excitatory amino acid transporter 3 Excitatory amino-acid carrier 1 Neuronal and epithelial glutamate transporter Sodium-dependent glutamate/aspartate transporter 3 Solute carrier family 1 member 1 gene 1291 0.0580578706980573 VASH1 D - Genome Maintenance endoplasmic reticulum IDA apical part of cell IDA extracellular space IDA negative regulation of endothelial cell proliferation IDA negative regulation of angiogenesis IDA cell cycle arrest IEA angiogenesis IDA negative regulation of blood vessel endothelial cell migration IDA Vasohibin-1 10470851 12508121 15467828 15489334 15649403 16488400 16707096 17974005 NA VASH1 -1 Vasohibin-1 gene 2094 0.0112763430619318 MARCKSL1 C - Cellular Fate and Organization cytoplasm IEA plasma membrane IDA positive regulation of cell proliferation IEA MARCKS-related protein; MARCKS-like protein 1; Macrophage myristoylated alanine-rich C kinase substrate; Mac-MARCKS; MacMARCKS 15489334 16710414 17081983 17525332 17974005 18669648 19690332 20068231 21269460 21406692 NA MRP 1 MARCKS-related protein MARCKS-like protein 1 Macrophage myristoylated alanine-rich C kinase substrate Mac-MARCKS MacMARCKS gene 1291 0.00273821266996665 FBLN1 C - Cellular Fate and Organization extracellular matrix (sensu Metazoa) TAS extracellular space IDA basement membrane IEA embryo implantation IEA extracellular matrix organization and biogenesis IEA virus-host interaction IEA protease activator activity IEA calcium ion binding IEA extracellular matrix structural constituent TAS Fibulin-1; FIBL-1; Precursor 10318851 10591208 11238726 11792823 11829738 11836357 11850827 12200142 12644824 1400330 15489334 15498874 2269669 2527614 7534784 7642629 8552629 8737292 9106159 9278415 9393974 9466671 9811350 9927660 NA FBLN1 -1 Fibulin-1 FIBL-1 Precursor gene 1443 0.020077089894473 TP63 D - Genome Maintenance transcription factor complex IBA nuclear chromatin IDA Golgi apparatus IDA nucleoplasm IDA dendrite IBA cytosol IBA establishment of planar polarity IEA response to X-ray IBA multicellular organismal aging IEA proximal/distal pattern formation IEA embryonic limb morphogenesis IEA neuron apoptosis IEA hair follicle morphogenesis IEA negative regulation of keratinocyte differentiation IEA regulation of neuron apoptosis IBA polarized epithelial cell differentiation IEA Notch signaling pathway IEA protein homotetramerization IPI smooth muscle development IEA positive regulation of transcription from RNA polymerase II promoter IDA epithelial cell development IEA odontogenesis (sensu Vertebrata) IEA female genitalia morphogenesis IEA chromatin remodeling IEA DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IBA positive regulation of Notch signaling pathway IDA negative regulation of apoptosis IEA cell aging IEA positive regulation of mesenchymal cell proliferation IEA induction of apoptosis TAS negative regulation of transcription from RNA polymerase II promoter IBA keratinocyte proliferation IEA sympathetic nervous system development IEA positive regulation of osteoblast differentiation IMP DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis IBA skeletal development IEA keratinocyte differentiation IEA skin morphogenesis IEA G1 DNA damage checkpoint IBA ectoderm and mesoderm interaction IEA damaged DNA binding IBA sequence-specific DNA binding IBA p53 binding IBA double-stranded DNA binding IBA transcription factor activity IBA chromatin binding IBA metal ion binding IEA Tumor protein 63; p63; Chronic ulcerative stomatitis protein; CUSP; Keratinocyte transcription factor KET; Transformation-related protein 63; TP63; Tumor protein p73-like; p73L; p40; p51 10373484 10469295 10485447 10535733 10839977 10935472 11159940 11248048 11336476 11462173 11477076 11528512 11641404 11925430 11929852 12374749 12446779 12446784 12766194 12838557 12939657 15200513 15489334 16740912 17846787 18806757 20123734 22197488 9662346 9662378 9703973 9774969 9799841 NA P63 -1 Tumor protein 63 p63 Chronic ulcerative stomatitis protein CUSP Keratinocyte transcription factor KET Transformation-related protein 63 TP63 Tumor protein p73-like p73L p40 p51 TF 1291 0.154520757008592 PDGFB D - Genome Maintenance basolateral plasma membrane ISS Golgi membrane TAS cell surface IDA endoplasmic reticulum lumen TAS extracellular region NAS platelet alpha granule lumen TAS actin cytoskeleton organization and biogenesis IEA substrate-bound cell migration IEA blood vessel morphogenesis IEA positive regulation of cyclin-dependent protein kinase activity IDA positive regulation of fibroblast proliferation IDA heart development ISS positive regulation of phosphoinositide 3-kinase activity IDA peptidyl-serine phosphorylation IDA positive regulation of chemotaxis IDA positive regulation of MAPK activity IDA activation of protein kinase B IDA transforming growth factor beta receptor signaling pathway ISS positive regulation of cell division IEA response to estradiol stimulus IEA positive regulation of protein amino acid autophosphorylation IDA response to hypoxia IEA negative regulation of cell migration IEA positive regulation of fibroblast growth factor receptor signaling pathway IEA response to drug IEA positive regulation of DNA replication IDA embryonic placenta development ISS platelet activation TAS positive regulation of mitosis IDA peptidyl-tyrosine phosphorylation IDA positive regulation of phosphoinositide 3-kinase cascade IDA positive regulation of smooth muscle cell proliferation IDA monocyte chemotaxis IDA DNA replication IEA positive regulation of blood vessel endothelial cell migration IDA positive regulation of endothelial cell proliferation IDA cell projection biogenesis IEA platelet degranulation TAS cell growth IEA positive regulation of transcription, DNA-dependent IDA negative regulation of transcription, DNA-dependent IDA eukaryotic cell surface binding IDA superoxide-generating NADPH oxidase activator activity IDA collagen binding IDA platelet-derived growth factor receptor binding NAS chemoattractant activity IDA protein homodimerization activity IDA Platelet-derived growth factor subunit B; PDGF subunit B; PDGF-2; Platelet-derived growth factor B chain; Platelet-derived growth factor beta polypeptide; Proto-oncogene c-Sis; Becaplermin; Precursor 10591208 11331882 12660034 1317862 1396586 15461802 15489334 1661670 18483217 20534510 2991848 3456904 3472769 3517869 4033772 6306471 6327048 6329745 6740330 6844921 7659502 8988177 NA PDGFB -1 Platelet-derived growth factor subunit B PDGF subunit B PDGF-2 Platelet-derived growth factor B chain Platelet-derived growth factor beta polypeptide Proto-oncogene c-Sis Becaplermin Precursor gene 1291 0.21126419773979 PDGFA D - Genome Maintenance microvillus ISS Golgi membrane TAS cell surface IDA endoplasmic reticulum lumen TAS platelet alpha granule lumen TAS extracellular space IDA positive regulation of protein kinase B signaling cascade IDA actin cytoskeleton organization and biogenesis ISS regulation of peptidyl-tyrosine phosphorylation ISS positive regulation of fibroblast proliferation IDA embryonic development TAS response to inorganic substance IEA positive regulation of MAPK activity IDA organ morphogenesis ISS positive regulation of cell division IEA transforming growth factor beta receptor signaling pathway IEA response to estradiol stimulus IEA hair follicle development ISS positive regulation of protein amino acid autophosphorylation IDA response to hypoxia IEA inner ear development IEA alveolus development ISS response to drug IEA positive regulation of DNA replication IDA negative chemotaxis IDA platelet activation TAS positive regulation of phosphoinositide 3-kinase cascade IDA positive regulation of mesenchymal cell proliferation ISS angiogenesis ISS cell projection biogenesis ISS platelet degranulation TAS skin development ISS eukaryotic cell surface binding IDA collagen binding IDA platelet-derived growth factor receptor binding IDA protein homodimerization activity IDA Platelet-derived growth factor subunit A; PDGF subunit A; PDGF-1; Platelet-derived growth factor A chain; Platelet-derived growth factor alpha polypeptide; Precursor 10358027 12853948 1317862 1612586 18483217 19054851 20534510 2832727 3422746 3614363 3614364 3666150 3754619 8486521 NA PDGFA -1 Platelet-derived growth factor subunit A PDGF subunit A PDGF-1 Platelet-derived growth factor A chain Platelet-derived growth factor alpha polypeptide Precursor gene 2291 1.0 CUX1 C - Cellular Fate and Organization integral to Golgi membrane IEA Golgi membrane IEA nucleus IDA cytosol TAS auditory receptor cell differentiation IEA lung development IEA intra-Golgi vesicle-mediated transport IEA multicellular organismal development TAS negative regulation of transcription from RNA polymerase II promoter TAS retrograde transport, vesicle recycling within Golgi IEA transcription, DNA-dependent IEA sequence-specific DNA binding IEA transcription factor activity IEA chromatin binding IEA Protein CASP 10607901 12853948 1301999 14702039 15489334 17525332 18669648 19690332 20068231 21269460 9799793 10607901 12429822 12853948 14702039 15489334 15718469 16959974 17525332 21269460 9332351 NA CASP 0 Protein CASP TF 1291 0.199549309027409 ENC1 F - Protein Fate cytoplasm IEA nucleus TAS cytoskeleton IEA nuclear matrix IEA protein ubiquitination IEA nervous system development TAS Ectoderm-neural cortex protein 1; ENC-1; Kelch-like protein 37; Nuclear matrix protein NRP/B; p53-induced gene 10 protein 14702039 15372022 15489334 15983046 19424503 19690332 9305847 9566959 9683534 NA ENC1 1 Ectoderm-neural cortex protein 1 ENC-1 Kelch-like protein 37 Nuclear matrix protein NRP/B p53-induced gene 10 protein gene 1291 0.0112763430619318 C - Cellular Fate and Organization cytoplasm IDA endoplasmic reticulum IEA nucleus IDA signal transduction TAS regulation of transcription, DNA-dependent TAS epidermis development TAS retinoic acid metabolic process IEA embryonic forelimb morphogenesis IEA transporter activity IEA retinoic acid binding IEA retinoid binding TAS retinal binding IEA retinol binding IEA Cellular retinoic acid-binding protein 2; Cellular retinoic acid-binding protein II; CRABP-II 10531482 11909957 1309505 1334086 14702039 15489334 15866176 1654334 16710414 16979656 17447762 21269460 21697133 21998312 7704533 9600845 9737849 9737883 NA RABP2 1 Cellular retinoic acid-binding protein 2 Cellular retinoic acid-binding protein II CRABP-II gene 1291 0.00125118998116012 TRHDE C - Cellular Fate and Organization integral to plasma membrane TAS signal transduction TAS proteolysis IEA cell-cell signaling TAS aminopeptidase activity TAS zinc ion binding IEA metalloendopeptidase activity IEA Thyrotropin-releasing hormone-degrading ectoenzyme; TRH-DE; TRH-degrading ectoenzyme; 3.4.19.6; Pyroglutamyl-peptidase II; PAP-II; TRH-specific aminopeptidase; Thyroliberinase 10491199 12975309 15489334 NA TRHDE -1 Thyrotropin-releasing hormone-degrading ectoenzyme TRH-DE TRH-degrading ectoenzyme 3.4.19.6 Pyroglutamyl-peptidase II PAP-II TRH-specific aminopeptidase Thyroliberinase gene 1291 0.00874128630945346 TFAM D - Genome Maintenance mitochondrial nucleoid IDA DNA-dependent DNA replication TAS regulation of transcription from RNA polymerase I promoter TAS transcription initiation from mitochondrial promoter IDA positive regulation of transcription, DNA-dependent IDA transcription factor activity IMP DNA bending activity IDA chromatin binding IDA Transcription factor A, mitochondrial; mtTFA; Mitochondrial transcription factor 1; MtTF1; Transcription factor 6; TCF-6; Transcription factor 6-like 2; Precursor 12897151 14702039 15164054 15489334 1610904 1737790 18063578 18669648 19054851 19304746 2035027 20410300 21269460 21406692 22037171 22037172 NA TFAM 1 Transcription factor A, mitochondrial mtTFA Mitochondrial transcription factor 1 MtTF1 Transcription factor 6 TCF-6 Transcription factor 6-like 2 Precursor gene 22944 1.0 TP53 D - Genome Maintenance mitochondrion IDA cytoplasm IDA nuclear chromatin IDA chromatin assembly complex IDA endoplasmic reticulum IEA PML body IDA replication fork IBA nucleolus IDA nucleus IDA nuclear matrix IDA cytosol IDA negative regulation of cell growth IMP response to salt stress IEA ER overload response IDA rRNA transcription IEA somitogenesis IEA positive regulation of peptidyl-tyrosine phosphorylation ISS neuron apoptosis IEA negative regulation of neuroblast proliferation IEA cell differentiation TAS positive regulation of neuron apoptosis IBA T cell lineage commitment IEA transforming growth factor beta receptor signaling pathway IEA DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IMP B cell lineage commitment IEA positive regulation of protein oligomerization IDA response to antibiotic IEP DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS protein import into nucleus, translocation IEA negative regulation of transcription from RNA polymerase II promoter IDA central nervous system development IEA embryonic development (sensu Mammalia) IEA DNA strand renaturation IDA DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis IDA base-excision repair TAS nucleotide-excision repair IMP chromosome organization and biogenesis IEA gastrulation IEA response to X-ray IBA cell proliferation TAS negative regulation of fibroblast proliferation IMP release of cytochrome c from mitochondria IEA Ras protein signal transduction IEP determination of adult life span ISS double-strand break repair IEA T cell proliferation during immune response IEA protein localization IDA body growth IEA positive regulation of transcription from RNA polymerase II promoter IDA cell cycle arrest IMP cellular response to glucose starvation IDA negative regulation of transforming growth factor beta receptor signaling pathway IEA regulation of mitochondrial membrane permeability TAS negative regulation of apoptosis IDA protein tetramerization TAS negative regulation of helicase activity TAS induction of apoptosis IEA positive regulation of histone deacetylation IBA blood coagulation TAS virus-host interaction IEA negative regulation of DNA replication IEA damaged DNA binding IBA p53 binding IBA histone deacetylase regulator activity IEA copper ion binding IDA chromatin binding IDA zinc ion binding TAS ATP binding IDA Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53 10484981 10549356 10551826 10570149 10606744 10644996 10656795 10722742 10884347 10951572 11007800 11023613 11025664 11058590 11124955 11239457 11447225 11481490 11546806 11551930 11554448 11554766 11672523 11706030 11740489 11780126 11925430 12085209 12507430 12702766 12724314 12750254 12810724 12851404 12944468 1303181 1327751 1394225 1437144 14534297 1459726 14660794 14702039 14702041 15053879 15053880 15109303 15186775 15340061 15489334 15525938 1565144 15701641 15855171 15866171 16131611 16219768 1631151 16322561 16376338 16377624 16402859 16415881 16474402 1647768 16625196 16704422 1672732 16793544 16845383 1694291 16959974 1699228 17015838 1705009 17108107 17108971 17170702 17224074 17245430 17254968 17311302 17317671 17349958 1737852 17467953 17525332 17591690 17707234 17805299 17904127 17967874 18022393 18206965 18453682 1848668 1849234 18650397 1868473 18996393 1905840 1915267 1933902 19473992 19509332 19515728 19536131 19556538 19608861 19776115 1978757 19880522 1999338 20041275 20096447 20118233 20124405 20142040 20173098 20228809 20364130 20385133 20660729 20673990 20870725 20959462 21269460 21317932 2141171 2156209 21946351 21952639 2259385 2263646 22726440 22864287 2905688 2946935 3025664 3894933 4006916 6396087 7682763 7773777 7878469 7887414 8013454 8023157 8023159 8118819 8266092 8316628 8336944 8402617 8632903 8632915 8718514 8825920 8829627 8829653 8875926 8875929 9101296 9321402 9372954 9419979 9450901 9452042 9840937 NA P53 0 Cellular tumor antigen p53 Antigen NY-CO-13 Phosphoprotein p53 Tumor suppressor p53 TF 1291 0.0783685434449873 FEN1 D - Genome Maintenance mitochondrion IDA nucleolus IEA nucleoplasm TAS S phase of mitotic cell cycle TAS UV protection TAS base-excision repair TAS phosphoinositide-mediated signaling NAS telomere maintenance via recombination TAS memory IEA DNA replication, removal of RNA primer IDA telomere maintenance via semi-conservative replication TAS double-strand break repair TAS damaged DNA binding TAS magnesium ion binding IEA double-stranded DNA binding TAS 5'-3' exonuclease activity IDA manganese ion binding IEA ribonuclease H activity IDA 5'-flap endonuclease activity IDA double-stranded DNA specific exodeoxyribonuclease activity TAS Flap endonuclease 1; FEN-1; 3.1.-.-; DNase IV; Flap structure-specific endonuclease 1; Maturation factor 1; MF1; hFEN-1 10744741 11430825 11986308 15489334 15576034 15616578 16554811 18443037 18499658 19608861 20068231 20729856 21269460 7774922 7961795 8007985 8621570 9305916 NA FEN1 1 Flap endonuclease 1 FEN-1 3.1.-.- DNase IV Flap structure-specific endonuclease 1 Maturation factor 1 MF1 hFEN-1 gene 1291 0.110735761722654 ACVRL1 D - Genome Maintenance cell surface IDA integral to plasma membrane IDA cell soma IEA dendrite IEA negative regulation of cell growth IDA wound healing, spreading of epidermal cells IMP negative regulation of cell proliferation IMP blood vessel endothelial cell proliferation during sprouting angiogenesis TAS BMP signaling pathway IMP protein heterooligomerization IEA embryonic development (sensu Mammalia) IEA negative regulation of focal adhesion formation IMP positive regulation of BMP signaling pathway IDA lymphangiogenesis ISS positive regulation of endothelial cell proliferation IEA negative regulation of endothelial cell proliferation IEA blood vessel remodeling ISS regulation of endothelial cell proliferation TAS positive regulation of transcription from RNA polymerase II promoter IDA blood pressure regulation IMP transforming growth factor beta receptor signaling pathway IDA positive regulation of chondrocyte differentiation TAS blood vessel maturation TAS positive regulation of endothelial cell differentiation IEA regulation of DNA replication TAS negative regulation of blood vessel endothelial cell migration IMP negative regulation of endothelial cell differentiation IEA activin receptor activity, type I IDA receptor signaling protein serine/threonine kinase activity IEA activin binding IDA transforming growth factor beta receptor activity IDA SMAD binding IDA ATP binding IDA transforming growth factor beta receptor activity, type I IEA metal ion binding IEA Serine/threonine-protein kinase receptor R3; SKR3; 2.7.11.30; Activin receptor-like kinase 1; ALK-1; TGF-B superfamily receptor type I; TSR-I; Precursor 10694922 10767348 11170071 11484689 14684682 15024723 15489334 15712270 16541075 22718755 22799562 8242742 8397373 8640225 9245985 NA ACVL1 -1 Serine/threonine-protein kinase receptor R3 SKR3 2.7.11.30 Activin receptor-like kinase 1 ALK-1 TGF-B superfamily receptor type I TSR-I Precursor gene 4315 0.0169618782683539 C - Cellular Fate and Organization cytoplasm IEA ribonucleoprotein complex IDA nucleus TAS cell proliferation TAS protein amino acid phosphorylation TAS multicellular organismal development TAS transcription, DNA-dependent IEA sequence-specific DNA binding IEA transcription factor activity IEA signal transducer activity TAS DNA binding TAS Transcriptional regulator ERG; Transforming protein ERG 14693372 14702039 15351649 15489334 16303180 17289661 3299708 3476934 8076344 8187069 8290279 NA ERG -1 Transcriptional regulator ERG Transforming protein ERG TF 35331 0.730732290367467 known -1 mir 1291 0.0684467560661034 COLEC12 A - Transport and Sensing collagen IEA integral to membrane TAS carbohydrate mediated signaling NAS innate immune response TAS protein homooligomerization NAS phagocytosis, recognition IDA galactose binding NAS low-density lipoprotein binding IDA metal ion binding IEA scavenger receptor activity TAS pattern recognition receptor activity IDA Collectin-12; Collectin placenta protein 1; CL-P1; hCL-P1; Nurse cell scavenger receptor 2; Scavenger receptor class A member 4; Scavenger receptor with C-type lectin 11162630 11564734 12601552 12761161 15489334 15845541 16177791 16868960 17420244 17974005 NA COL12 1 Collectin-12 Collectin placenta protein 1 CL-P1 hCL-P1 Nurse cell scavenger receptor 2 Scavenger receptor class A member 4 Scavenger receptor with C-type lectin gene 1291 0.00650852447032351 SCRN1 F - Protein Fate cytoplasm IEA nuclear membrane IDA proteolysis IEA exocytosis ISS dipeptidase activity IEA Secernin-1 11921445 12168954 12853948 14702039 15489334 16630140 21269460 8724849 NA SCRN1 1 Secernin-1 gene 1291 0.00106232178122635 C - Cellular Fate and Organization mitochondrial nucleoid IDA mitochondrial intermembrane space IEA microtubule cytoskeleton IDA mitochondrial inner membrane IDA positive regulation of cell proliferation IEA protein homotetramerization IEA L-serine biosynthetic process IEA one-carbon compound metabolic process IDA glycine biosynthetic process from serine IEA chromatin binding IDA methyltransferase activity IEA pyridoxal phosphate binding IEA glycine hydroxymethyltransferase activity IDA L-allo-threonine aldolase activity IEA amino acid binding IEA Serine hydroxymethyltransferase, mitochondrial; SHMT; 2.1.2.1; Glycine hydroxymethyltransferase; Serine methylase; Precursor 10828359 14702039 15489334 16541075 18063578 19608861 21269460 21876188 8505317 8999870 NA GLYM 1 Serine hydroxymethyltransferase, mitochondrial SHMT 2.1.2.1 Glycine hydroxymethyltransferase Serine methylase Precursor gene 1530 2.78062840772495E-6 RTKN2 C - Cellular Fate and Organization intracellular IEA plasma membrane IEA hemopoiesis IEA signal transduction IEA positive regulation of cell proliferation IEA phospholipid binding IEA Rhotekin-2; Pleckstrin homology domain-containing family K member 1; PH domain-containing family K member 1 14702039 15120425 15164054 15489334 15504364 17974005 NA RTKN2 -1 Rhotekin-2 Pleckstrin homology domain-containing family K member 1 PH domain-containing family K member 1 gene 54903 0.994810733858276 novel -1 mir 1291 4.58870887597033E-4 FAM50A D - Genome Maintenance nucleus NAS spermatogenesis NAS Protein FAM50A; Protein HXC-26; Protein XAP-5 14702039 15489334 15772651 21269460 8733135 9039504 9339379 NA FA50A 1 Protein FAM50A Protein HXC-26 Protein XAP-5 gene 1291 0.0269693795303448 DACH1 C - Cellular Fate and Organization transcription factor complex IEA cytoplasm IEA nucleolus IDA development of primary female sexual characteristics IEA negative regulation of cell migration IDA suckling behavior IEA respiratory gaseous exchange IEA cell proliferation IEA negative regulation of fibroblast proliferation IEA nucleotide binding IEA DNA binding IEA Dachshund homolog 1; Dach1 10502110 11543628 12057194 14525983 15057823 15489334 9651501 NA DACH1 -1 Dachshund homolog 1 Dach1 gene 1291 0.0218918562607483 D - Genome Maintenance transcription factor complex IDA positive regulation of protein catabolic process IEA negative regulation of cell growth IMP positive regulation of cell differentiation IEA protein stabilization IMP negative regulation of mesodermal cell fate specification IEA negative regulation of transcription from RNA polymerase II promoter IEA angiogenesis ISS inner cell mass cellular morphogenesis IEA spermatogenesis IEA positive regulation of skeletal muscle development IEA stem cell fate specification IEA heart looping ISS protein destabilization IMP regulation of embryonic development ISS cell migration involved in gastrulation IEA endodermal cell fate determination IEA positive regulation of transcription from RNA polymerase II promoter IDA embryonic organ development IEA embryonic foregut morphogenesis ISS mRNA transcription from RNA polymerase II promoter IDA rostrocaudal neural tube patterning IEA vasculogenesis ISS sequence-specific DNA binding IEA RNA polymerase II transcription factor activity, enhancer binding ISS transcription coactivator activity IEA Transcription factor SOX-17 11786926 14702039 20960469 NA SOX17 -1 Transcription factor SOX-17 gene 1697 0.0474423100358454 PIK3R1 C - Cellular Fate and Organization plasma membrane TAS membrane IEA phosphoinositide 3-kinase complex IEA 1-phosphatidylinositol-4-phosphate kinase, class IA complex ISS insulin receptor signaling pathway IPI T cell receptor signaling pathway TAS nerve growth factor receptor signaling pathway TAS negative regulation of apoptosis IEA positive regulation of cell migration IEA positive regulation of apoptosis IEA phosphatidylinositol biosynthetic process TAS T cell costimulation TAS platelet activation TAS negative regulation of osteoclast differentiation IEA NFAT protein import into nucleus IEA leukocyte migration TAS phosphoinositide 3-kinase cascade IDA phosphoinositide phosphorylation ISS epidermal growth factor receptor signaling pathway TAS fibroblast growth factor receptor signaling pathway TAS regulation of phosphoinositide 3-kinase activity IEA virus-host interaction IEA positive regulation of glucose import ISS positive regulation of transcription from RNA polymerase II promoter IEA B cell differentiation IEA protein amino acid phosphorylation IEA insulin-like growth factor receptor signaling pathway IPI negative regulation of cell-matrix adhesion IEA phosphatidylinositol binding NAS kinase activity IEA phosphoinositide 3-kinase regulator activity IEA transmembrane receptor protein tyrosine kinase adaptor protein activity ISS insulin receptor substrate binding ISS insulin binding IDA ErbB-3 class receptor binding IDA phosphoinositide 3-kinase binding ISS Phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha 10086340 10528161 10739672 10768093 10867024 11087752 11526404 11567151 11912194 12009866 12186904 12359715 14702039 15302586 15372022 15488758 15489334 15526160 15561106 15592455 15863030 17626883 18079394 18348712 1849461 18721752 19286672 19369195 19690332 19805105 19807924 19919182 7518429 7537849 7541045 7681364 7692233 8276809 8599763 8628286 8648629 8670861 8940081 8961927 8962058 9032108 9038210 9178760 9489702 9553137 9687533 NA P85A -1 Phosphatidylinositol 3-kinase regulatory subunit alpha PI3-kinase regulatory subunit alpha PI3K regulatory subunit alpha PtdIns-3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha PI3-kinase subunit p85-alpha PtdIns-3-kinase regulatory subunit p85-alpha gene 1291 0.0125304158240803 STXBP6 A - Transport and Sensing cytoplasm IEA integral to membrane IEA vesicle-mediated transport IEA Syntaxin-binding protein 6; Amisyn 11042152 12145319 12508121 14702039 15489334 17974005 NA STXB6 -1 Syntaxin-binding protein 6 Amisyn gene 1307 0.270006647068622 D - Genome Maintenance cytoplasm IDA filamentous actin IDA plasma membrane IDA nucleolus IDA ruffle IDA substrate-bound cell migration, cell extension TAS signal transduction NAS mitosis IEA protein complex assembly TAS cell division IEA structural constituent of cytoskeleton TAS CD2-associated protein; Adapter protein CMS; Cas ligand with multiple SH3 domains 10339567 11067845 12764198 14574404 15489334 15800069 16678097 16895919 17020880 17188587 17853893 17974005 18088087 18220336 18669648 19690332 20068231 21269460 21406692 NA CD2AP 1 CD2-associated protein Adapter protein CMS Cas ligand with multiple SH3 domains gene 1291 0.0151106267335785 SOX12 N - Not Matched nucleus IEA cell fate commitment IEP spinal cord development ISS protein-DNA complex assembly IEA Transcription factor SOX-12; Protein SOX-22 11780052 15489334 9215677 NA SOX12 1 Transcription factor SOX-12 Protein SOX-22 gene 2683 1.0 C - Cellular Fate and Organization cytoplasm IDA nucleus IDA spinal cord development ISS kidney development IEA embryonic skeletal morphogenesis ISS negative regulation of transcription from RNA polymerase II promoter IDA positive regulation of ossification IMP sympathetic nervous system development ISS glial cell proliferation ISS neural tube formation ISS negative regulation of lymphocyte proliferation IMP positive regulation of osteoblast differentiation IMP positive regulation of BMP signaling pathway ISS glial cell development ISS embryonic digestive tract morphogenesis ISS lens morphogenesis (sensu Vertebrata) ISS neural crest cell development ISS positive regulation of neurogenesis ISS positive regulation of neuron differentiation IMP oligodendrocyte development IEA positive regulation of hormone secretion ISS regulation of transforming growth factor beta receptor signaling pathway IEP hard palate development ISS soft palate development ISS translation factor activity, nucleic acid binding IDA Transcription factor SOX-11 10574465 15815621 18669648 8332506 8666406 NA SOX11 0 Transcription factor SOX-11 TF 2626 0.00720864440325071 D - Genome Maintenance cytoplasm IDA extracellular space IDA calcium-mediated signaling IDA cartilage development IEA regulation of pH IEA protein kinase cascade IEA regulation of vasoconstriction IEA heart development IEA negative regulation of hormone secretion IEA glucose transport IEA neural crest cell development IEA prostaglandin biosynthetic process IDA elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) IEA positive regulation of hormone secretion IDA response to lipopolysaccharide IEA G-protein signaling, phospholipase D activating pathway IEA rhythmic excitation IEA positive regulation of mitosis IDA negative regulation of transcription from RNA polymerase II promoter IDA embryonic development (sensu Mammalia) IEA phosphoinositide 3-kinase cascade IDA negative regulation of cellular protein metabolic process IDA positive regulation of cell size IDA leukocyte activation TAS G-protein coupled receptor protein signaling pathway IDA cell growth IEA peptide hormone secretion IDA regulation of sensory perception of pain IEA membrane depolarization IEA positive regulation of odontogenesis IEA negative regulation of cAMP biosynthetic process IEA multicellular organismal aging IEA dorsal/ventral pattern formation IEA elevation of cytosolic calcium ion concentration IDA protein kinase C activation IEA positive regulation of nitric oxide biosynthetic process TAS epithelial fluid transport IEA protein kinase C deactivation IDA nitric oxide transport IDA positive regulation of smooth muscle contraction IEA middle ear morphogenesis IEA positive regulation of JNK activity IDA response to amino acid stimulus IEA fluid secretion IEA superoxide release IEA response to hypoxia IEA patterning of blood vessels IEA histamine secretion IEA respiratory gaseous exchange IEA inositol phosphate-mediated signaling IDA positive regulation of smooth muscle cell proliferation IDA sensory perception of pain IEA negative regulation of blood coagulation TAS negative regulation of nitric-oxide synthase biosynthetic process IDA response to nicotine IEA hormone activity IDA endothelin A receptor binding IDA endothelin B receptor binding IDA cytokine activity IDA Endothelin-1; Preproendothelin-1; PPET1; Endothelin-1; ET-1; Big endothelin-1; Precursor 10231710 10334806 10391210 10438732 1422154 14574404 1515112 15489334 1736987 1859417 1864385 2649896 2659594 2670930 3282927 7664037 7773179 8450044 9284755 NA EDN1 -1 Endothelin-1 Preproendothelin-1 PPET1 Endothelin-1 ET-1 Big endothelin-1 Precursor gene 1291 0.0586146050434715 ZNF331 T - Transcription nucleus NAS regulation of transcription, DNA-dependent NAS transcription, DNA-dependent IEA zinc ion binding NAS DNA binding NAS Zinc finger protein 331; C2H2-like zinc finger protein rearranged in thyroid adenomas; Zinc finger protein 361; Zinc finger protein 463 10502321 11267678 15489334 NA ZN331 -1 Zinc finger protein 331 C2H2-like zinc finger protein rearranged in thyroid adenomas Zinc finger protein 361 Zinc finger protein 463 gene 1291 0.0886312797080639 LAMP3 C - Cellular Fate and Organization integral to membrane IEA lysosomal membrane TAS cell proliferation TAS Lysosome-associated membrane glycoprotein 3; LAMP-3; Lysosomal-associated membrane protein 3; DC-lysosome-associated membrane glycoprotein; DC LAMP; Protein TSC403; CD208; Precursor 15489334 21930964 22809326 9721848 9768752 NA LAMP3 -1 Lysosome-associated membrane glycoprotein 3 LAMP-3 Lysosomal-associated membrane protein 3 DC-lysosome-associated membrane glycoprotein DC LAMP Protein TSC403 CD208 Precursor gene 1291 2.15150330025378E-4 T - Transcription nucleus IEA regulation of transcription, DNA-dependent IEA transcription, DNA-dependent IEA zinc ion binding IEA DNA binding IEA Zinc finger protein 692 14702039 15489334 16710414 17974005 NA ZN692 1 Zinc finger protein 692 gene 1291 1.75534659494616E-4 PCDH17 C - Cellular Fate and Organization plasma membrane IEA integral to membrane IEA homophilic cell adhesion IEA calcium ion binding IEA Protocadherin-17; Protocadherin-68; Precursor 14702039 15057823 15489334 17978184 NA PCD17 -1 Protocadherin-17 Protocadherin-68 Precursor gene 1291 0.0244174348753505 F - Protein Fate cytosol TAS amino acid metabolic process IEA proteolysis IEA aminoacylase activity TAS metallopeptidase activity IEA metal ion binding IEA Aminoacylase-1; ACY-1; 3.5.1.14; N-acyl-L-amino-acid amidohydrolase 12933810 15489334 16274666 16465618 16959974 17562838 21269460 21414403 8357837 8394326 NA ACY1 1 Aminoacylase-1 ACY-1 3.5.1.14 N-acyl-L-amino-acid amidohydrolase gene 1291 0.0244174348753505 MOGS F - Protein Fate endoplasmic reticulum membrane TAS integral to membrane IEA oligosaccharide metabolic process IEA protein folding TAS protein amino acid N-linked glycosylation via asparagine TAS mannosyl-oligosaccharide glucosidase activity IEA glucosidase activity TAS Mannosyl-oligosaccharide glucosidase; 3.2.1.106; Processing A-glucosidase I 10788335 12145188 14702039 15489334 21269460 7635146 NA MOGS 1 Mannosyl-oligosaccharide glucosidase 3.2.1.106 Processing A-glucosidase I gene 1291 0.0457785783868501 SNRK C - Cellular Fate and Organization nucleus ISS myeloid cell differentiation TAS magnesium ion binding IDA protein serine/threonine kinase activity IDA ATP binding IDA SNF-related serine/threonine-protein kinase; 2.7.11.1; SNF1-related kinase 12168954 12234663 14702039 15489334 15733851 17344846 17974005 19690332 7788527 8654423 NA SNRK -1 SNF-related serine/threonine-protein kinase 2.7.11.1 SNF1-related kinase gene 1912 4.65023783551767E-6 C - Cellular Fate and Organization transcription factor complex IEA cytoplasm IDA nucleoplasm TAS pattern specification process IEA negative regulation of cell migration IDA transcription initiation from RNA polymerase II promoter TAS lung development IEA positive regulation of transcription from RNA polymerase II promoter IMP cell-cell signaling IDA induction of apoptosis IDA embryonic forelimb morphogenesis IMP positive regulation of cardioblast differentiation IDA morphogenesis of an epithelium IEA cardiac muscle cell differentiation IEA sequence-specific DNA binding IDA transcription factor activity IDA T-box transcription factor TBX5; T-box protein 5 10077612 10842287 11183182 15489334 15735645 20450920 8988164 8988165 NA TBX5 -1 T-box transcription factor TBX5 T-box protein 5 gene 1291 0.0467346765150697 D - Genome Maintenance nucleus IDA positive regulation of cell proliferation IDA mammary gland development IMP negative regulation of myoblast differentiation IDA heart looping IEA male genitalia development IMP follicle-stimulating hormone secretion IMP negative regulation of epithelial cell differentiation IEA organ morphogenesis IDA palate development IEA mesoderm morphogenesis IMP determination of anterior/posterior axis, embryo IMP specification of organ position IEA negative regulation of apoptosis IDA blood vessel development IEA regulation of transcription from RNA polymerase II promoter TAS cell aging IDA negative regulation of transcription from RNA polymerase II promoter IEA embryonic development (sensu Mammalia) IEA positive regulation of progression through cell cycle IDA transcription, DNA-dependent IEA skeletal development IMP luteinizing hormone secretion IMP stem cell maintenance IEA limbic system development IEA embryonic forelimb morphogenesis IMP positive regulation of transcription, DNA-dependent IEA negative regulation of transcription, DNA-dependent IDA female genitalia development IMP embryonic digit morphogenesis IMP sequence-specific DNA binding IDA transcription factor activity IEA T-box transcription factor TBX3; T-box protein 3 10330342 10468588 12005433 15489334 18220336 18669648 9207801 NA TBX3 -1 T-box transcription factor TBX3 T-box protein 3 gene 1291 0.0439244987968563 T - Transcription transcription factor complex IEA nucleus IDA cardiac muscle development ISS cell aging IDA palate development IEA negative regulation of transcription from RNA polymerase II promoter IEA muscle cell fate determination ISS negative regulation of transcription, DNA-dependent IDA transcription, DNA-dependent IEA embryonic digit morphogenesis ISS embryonic eye morphogenesis (sensu Actinopterygii) ISS sequence-specific DNA binding IDA transcription factor activity IEA T-box transcription factor TBX2; T-box protein 2 15489334 16625196 8530034 8597636 NA TBX2 -1 T-box transcription factor TBX2 T-box protein 2 gene 1291 0.0684467560661034 A - Transport and Sensing mitochondrion IDA mitochondrial inner membrane IEA integral to membrane IEA erythrocyte differentiation IEA iron ion transport IEA cation transporter activity IEA Sideroflexin-1; Tricarboxylate carrier protein; TCC 14702039 15372022 15489334 17974005 21269460 NA SFXN1 1 Sideroflexin-1 Tricarboxylate carrier protein TCC gene 1291 0.0262453699169434 TIE1 C - Cellular Fate and Organization integral to plasma membrane TAS negative regulation of cell migration IEA negative regulation of angiogenesis IEA plasma membrane fusion IEA mesoderm development TAS angiogenesis IEA embryonic development (sensu Mammalia) IEA transmembrane receptor protein tyrosine kinase activity TAS ATP binding IEA Tyrosine-protein kinase receptor Tie-1; 2.7.10.1; Precursor 1312667 15340161 15489334 15851516 17344846 20227369 NA TIE1 -1 Tyrosine-protein kinase receptor Tie-1 2.7.10.1 Precursor gene 1291 0.00955317868538724 TLK1 D - Genome Maintenance nucleus IDA cell cycle IEA regulation of chromatin assembly or disassembly IDA intracellular protein transport IDA response to DNA damage stimulus IEA chromatin modification IEA protein serine/threonine kinase activity IDA ATP binding IDA Serine/threonine-protein kinase tousled-like 1; 2.7.11.1; PKU-beta; Tousled-like kinase 1 10523312 10588641 11314006 11470414 12168954 12660173 14702039 15489334 15815621 17344846 18669648 19369195 19690332 20068231 21269460 8590280 9427565 NA TLK1 1 Serine/threonine-protein kinase tousled-like 1 2.7.11.1 PKU-beta Tousled-like kinase 1 gene 1291 0.0979480891694494 NFS1 F - Protein Fate mitochondrial matrix IDA nucleus IDA cytosol IDA molybdopterin cofactor biosynthetic process TAS sulfur amino acid metabolic process TAS protein complex assembly TAS cysteine metabolic process IEA Mo-molybdopterin cofactor biosynthetic process IEA water-soluble vitamin metabolic process TAS iron incorporation into metallo-sulfur cluster IDA pyridoxal phosphate binding IEA cysteine desulfurase activity IDA catalytic activity IEA protein homodimerization activity IDA Cysteine desulfurase, mitochondrial; 2.8.1.7; Precursor 11060020 11124703 11780052 14702039 15489334 18650437 19454487 21269460 9885568 NA NFS1 1 Cysteine desulfurase, mitochondrial 2.8.1.7 Precursor gene 1291 0.0849340188103281 DDOST P - Translation integral to membrane IEA oligosaccharyl transferase complex ISS T cell activation IDA SRP-dependent cotranslational protein targeting to membrane TAS innate immune response TAS translation TAS protein amino acid N-linked glycosylation via asparagine IC dolichyl-diphosphooligosaccharide-protein glycotransferase activity IEA Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; DDOST 48 kDa subunit; Oligosaccharyl transferase 48 kDa subunit; 2.4.99.18; Precursor 14702039 15489334 16710414 21269460 22305527 7788527 9367678 NA OST48 1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit DDOST 48 kDa subunit Oligosaccharyl transferase 48 kDa subunit 2.4.99.18 Precursor gene 1291 9.22127029133089E-4 SLC52A2 A - Transport and Sensing integral to plasma membrane IDA riboflavin transporter activity IDA Solute carrier family 52, riboflavin transporter, member 2; Porcine endogenous retrovirus A receptor 1; PERV-A receptor 1; Protein GPR172A; Riboflavin transporter 3; hRFT3 12740431 14702039 15489334 16421571 19307586 20463145 22740598 NA S52A2 1 Solute carrier family 52, riboflavin transporter, member 2 Porcine endogenous retrovirus A receptor 1 PERV-A receptor 1 Protein GPR172A Riboflavin transporter 3 hRFT3 gene 1291 0.0109363272005778 ARMCX1 N - Not Matched integral to membrane IEA Armadillo repeat-containing X-linked protein 1; ARM protein lost in epithelial cancers on chromosome X 1; Protein ALEX1 11162520 14702039 15489334 15772651 NA ARMX1 -1 Armadillo repeat-containing X-linked protein 1 ARM protein lost in epithelial cancers on chromosome X 1 Protein ALEX1 gene 1291 0.00896578061676545 GABARAPL1 C - Cellular Fate and Organization autophagic vacuole IDA Golgi apparatus IEA endoplasmic reticulum IEA microtubule IEA cytoplasmic vesicle membrane IEA autophagy IEA beta-tubulin binding ISS GABA receptor binding ISS Gamma-aminobutyric acid receptor-associated protein-like 1; Early estrogen-regulated protein; GABA(A) receptor-associated protein-like 1; Glandular epithelial cell protein 1; GEC-1; Precursor 11230166 11374880 11414770 14702039 15489334 16431922 16541075 17580304 20404487 21269460 22470510 NA GBRL1 -1 Gamma-aminobutyric acid receptor-associated protein-like 1 Early estrogen-regulated protein GABA(A) receptor-associated protein-like 1 Glandular epithelial cell protein 1 GEC-1 Precursor gene 1291 0.664073298138274 N - Not Matched Z disc ISS nucleus ISS actin cytoskeleton IDA muscle alpha-actinin binding ISS Synaptopodin-2; Genethonin-2; Myopodin 11297942 11673475 15489334 15815621 17974005 18371299 NA SYNP2 -1 Synaptopodin-2 Genethonin-2 Myopodin gene 19508 5.76812752287377E-4 EGR1 C - Cellular Fate and Organization cytoplasm ISS nucleoplasm TAS transcription from RNA polymerase II promoter IDA oligodendrocyte differentiation IEA response to ethanol IEA BMP signaling pathway IEA negative regulation of transcription from RNA polymerase II promoter IEA response to cocaine IEA response to glucose stimulus IEA response to amphetamine IEA positive regulation of neuron apoptosis IEA T cell differentiation IEA positive regulation of transcription from RNA polymerase II promoter IDA regulation of long-term neuronal synaptic plasticity IEA response to electrical stimulus IEA learning and/or memory IEA circadian rhythm IEA response to nutrient levels IEA transcription factor activity IDA double-stranded DNA binding IEA zinc ion binding IEA Early growth response protein 1; EGR-1; AT225; Nerve growth factor-induced protein A; NGFI-A; Transcription factor ETR103; Transcription factor Zif268; Zinc finger protein 225; Zinc finger protein Krox-24 15489334 1569051 19690332 20121949 2110381 2377485 NA EGR1 -1 Early growth response protein 1 EGR-1 AT225 Nerve growth factor-induced protein A NGFI-A Transcription factor ETR103 Transcription factor Zif268 Zinc finger protein 225 Zinc finger protein Krox-24 TF 1291 0.00375315258666234 ADAMTS8 C - Cellular Fate and Organization extracellular matrix (sensu Metazoa) IEA negative regulation of cell proliferation TAS proteolysis IEA integrin binding TAS low affinity phosphate transporter activity TAS zinc ion binding IEA metalloendopeptidase activity IEA heparin binding IEA metallopeptidase activity TAS A disintegrin and metalloproteinase with thrombospondin motifs 8; ADAM-TS 8; ADAM-TS8; ADAMTS-8; 3.4.24.-; METH-2; METH-8; Precursor 10438512 10610729 16554811 NA ATS8 -1 A disintegrin and metalloproteinase with thrombospondin motifs 8 ADAM-TS 8 ADAM-TS8 ADAMTS-8 3.4.24.- METH-2 METH-8 Precursor gene 1291 0.0421510155284426 ATP2A2 M - Other Metabolism integral to plasma membrane TAS platelet dense tubular network membrane TAS ATP biosynthetic process IEA ER-nuclear signaling pathway IEA epidermis development TAS cardiac inotropy IEA blood coagulation TAS calcium ion homeostasis TAS cell adhesion TAS negative regulation of heart contraction IEA ATP binding IEA metal ion binding IEA Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; SERCA2; SR Ca(2+)-ATPase 2; 3.6.3.8; Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase 10080178 10441323 10441324 10441325 12542527 12659872 14702039 14749390 15489334 16399855 16402920 16541075 17081983 18669648 18691976 18971376 19690332 19995371 21269460 2844796 NA AT2A2 1 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 SERCA2 SR Ca(2+)-ATPase 2 3.6.3.8 Calcium pump 2 Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform Endoplasmic reticulum class 1/2 Ca(2+) ATPase gene 1291 0.0134562520322556 SEC14L1 A - Transport and Sensing Golgi apparatus TAS membrane TAS integral to membrane IEA transport IEA SEC14-like protein 1 14702039 15489334 16625196 20068231 8697811 9110174 NA S14L1 -1 SEC14-like protein 1 gene 1291 0.100977645694874 ALDH1L1 N - Not Matched mitochondrion IEA biosynthetic process IEA one-carbon compound metabolic process IEA methylation IEA 10-formyltetrahydrofolate catabolic process TAS formyltetrahydrofolate dehydrogenase activity IEA methyltransferase activity IEA oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA catalytic activity TAS hydroxymethyl-, formyl- and related transferase activity IEA Cytosolic 10-formyltetrahydrofolate dehydrogenase; 10-FTHFDH; FDH; 1.5.1.6; Aldehyde dehydrogenase family 1 member L1 14702039 16641997 16959974 17057331 17974005 20498374 NA AL1L1 -1 Cytosolic 10-formyltetrahydrofolate dehydrogenase 10-FTHFDH FDH 1.5.1.6 Aldehyde dehydrogenase family 1 member L1 gene 1291 0.0295186898975597 ADAMTS1 C - Cellular Fate and Organization cytoplasmic vesicle IEA basement membrane IEA negative regulation of cell proliferation TAS kidney development IEA integrin-mediated signaling pathway TAS proteolysis IEA ovulation (sensu Mammalia) IEA zinc ion binding IEA metalloendopeptidase activity IEA heparin binding IEA metallopeptidase activity TAS A disintegrin and metalloproteinase with thrombospondin motifs 1; ADAM-TS 1; ADAM-TS1; ADAMTS-1; 3.4.24.-; METH-1; Precursor 10438512 10718198 10785405 10830953 17974005 NA ATS1 -1 A disintegrin and metalloproteinase with thrombospondin motifs 1 ADAM-TS 1 ADAM-TS1 ADAMTS-1 3.4.24.- METH-1 Precursor gene 1291 0.113998436121522 C - Cellular Fate and Organization integral to plasma membrane IDA endoplasmic reticulum membrane IEA nuclear envelope IEA protein ubiquitination during ubiquitin-dependent protein catabolic process IDA Wnt receptor signaling pathway IEA ubiquitin-protein ligase activity IDA zinc ion binding IEA E3 ubiquitin-protein ligase RNF43; 6.3.2.-; RING finger protein 43; Precursor 14702039 15489334 15492824 15623641 17974005 18313049 18655028 22575959 22895187 NA RNF43 1 E3 ubiquitin-protein ligase RNF43 6.3.2.- RING finger protein 43 Precursor gene 1291 2.40714615952985E-5 FAM83A Protein FAM83A; Tumor antigen BJ-TSA-9; Tumor-specific gene expressed in prostate protein 14702039 15489334 18669648 NA FA83A 1 Protein FAM83A Tumor antigen BJ-TSA-9 Tumor-specific gene expressed in prostate protein gene 1291 0.0617358293036639 C - Cellular Fate and Organization membrane NAS phosphoinositide phosphorylation IEA cell communication NAS inositol-polyphosphate 5-phosphatase activity NAS Type I inositol 1,4,5-trisphosphate 5-phosphatase; 5PTase; 3.1.3.56; Precursor 15164054 15489334 8006039 8013665 NA I5P1 -1 Type I inositol 1,4,5-trisphosphate 5-phosphatase 5PTase 3.1.3.56 Precursor gene 1291 0.0080442634822031 SPTAN1 C - Cellular Fate and Organization fascia adherens IEA spectrin TAS Z disc IEA membrane TAS microtubule cytoskeleton IDA cuticular plate IEA lateral plasma membrane IEA cytosol TAS intracellular membrane-bound organelle IDA axon guidance TAS cell structure disassembly during apoptosis TAS actin filament capping IEA calcium ion binding IEA structural constituent of cytoskeleton TAS actin binding TAS Spectrin alpha chain, non-erythrocytic 1; Alpha-II spectrin; Fodrin alpha chain; Spectrin, non-erythroid alpha subunit 10625438 11971983 15164053 15328537 15489334 16945920 16959974 17081983 18048348 18669648 19608861 19690332 20068231 20493457 21269460 21406692 2307671 3038643 3691949 7607240 8993318 NA SPTN1 -1 Spectrin alpha chain, non-erythrocytic 1 Alpha-II spectrin Fodrin alpha chain Spectrin, non-erythroid alpha subunit gene 1291 0.018030555180901 CEP68 D - Genome Maintenance cytoplasm IEA centrosome IDA centrosome organization and biogenesis IMP Centrosomal protein of 68 kDa; Cep68 12168954 14654843 14702039 15489334 15815621 18669648 9628581 NA CEP68 -1 Centrosomal protein of 68 kDa Cep68 gene 1291 0.0525502643359139 A - Transport and Sensing cell junction IEA plasma membrane IEA postsynaptic membrane IEA extracellular ligand-gated ion channel activity IEA GABA-A receptor activity TAS chloride channel activity IEA Gamma-aminobutyric acid receptor subunit pi; GABA(A) receptor subunit pi; Precursor 14702039 15489334 16959974 9182563 NA GBRP -1 Gamma-aminobutyric acid receptor subunit pi GABA(A) receptor subunit pi Precursor gene 1291 0.0584361174484631 KCNN4 C - Cellular Fate and Organization voltage-gated potassium channel complex IC stabilization of membrane potential IDA positive regulation of protein secretion IEA synaptic transmission TAS calcium ion transport IDA defense response TAS positive regulation of T cell receptor signaling pathway IDA phospholipid translocation IEA regulation of cell volume IEA saliva secretion IEA calcium-activated potassium channel activity IDA small conductance calcium-activated potassium channel activity IEA Intermediate conductance calcium-activated potassium channel protein 4; SK4; SKCa 4; SKCa4; IKCa1; IK1; KCa3.1; KCa4; Putative Gardos channel 10026195 10961988 11425865 15489334 15831468 17157250 18796614 9326665 9380751 9407042 9693050 NA KCNN4 1 Intermediate conductance calcium-activated potassium channel protein 4 SK4 SKCa 4 SKCa4 IKCa1 IK1 KCa3.1 KCa4 Putative Gardos channel gene 1291 0.0586146050434715 ENG C - Cellular Fate and Organization cytoplasm IDA cell surface IDA nucleus IDA extracellular space IDA external side of plasma membrane IDA patterning of blood vessels ISS negative regulation of cell migration IDA artery morphogenesis ISS venous blood vessel morphogenesis ISS negative regulation of transcription from RNA polymerase II promoter IDA BMP signaling pathway TAS regulation of cell adhesion TAS negative regulation of protein amino acid autophosphorylation IDA heart looping ISS positive regulation of BMP signaling pathway IDA negative regulation of nitric-oxide synthase activity IMP extracellular matrix disassembly IMP negative regulation of endothelial cell proliferation IMP regulation of cell proliferation TAS positive regulation of transcription from RNA polymerase II promoter IDA smooth muscle development ISS wound healing IMP chronological cell aging IEA transforming growth factor beta receptor signaling pathway IDA regulation of transforming growth factor beta receptor signaling pathway IDA cell adhesion IEA central nervous system vasculogenesis IMP negative regulation of transforming growth factor beta receptor signaling pathway TAS transforming growth factor beta receptor, cytoplasmic mediator activity IDA galactose binding IDA activin binding TAS transforming growth factor beta receptor activity IDA glycosaminoglycan binding IDA transmembrane receptor activity NAS punt binding ISS Endoglin; CD105; Precursor 10545596 10625079 10982033 15024723 15164053 15712270 1692830 16982625 17540773 19159218 7894484 8370410 9157574 9245986 9554745 NA EGLN -1 Endoglin CD105 Precursor gene 1291 0.257028418487351 GAS2L1 D - Genome Maintenance stress fiber IEA cytoplasm IDA microtubule IEA negative regulation of cell growth IDA negative regulation of erythrocyte differentiation IDA microtubule bundle formation IMP negative regulation of microtubule depolymerization IMP regulation of cell cycle IDA cell cycle arrest ISS cellular response to starvation ISS microtubule binding IDA thyroid hormone receptor binding IDA cytoskeletal adaptor activity IDA GAS2-like protein 1; GAS2-related protein on chromosome 22; Growth arrest-specific protein 2-like 1 12584248 15489334 18088087 18220336 18669648 19690332 20068231 8975699 NA GA2L1 -1 GAS2-like protein 1 GAS2-related protein on chromosome 22 Growth arrest-specific protein 2-like 1 gene 1291 0.126227128319971 CGNL1 N - Not Matched tight junction IEA myosin complex IEA motor activity IEA Cingulin-like protein 1; Junction-associated coiled-coil protein; Paracingulin 11214970 12736278 14702039 15489334 21406692 NA CGNL1 -1 Cingulin-like protein 1 Junction-associated coiled-coil protein Paracingulin gene 1291 0.00711440475029733 GLT25D2 C - Cellular Fate and Organization endoplasmic reticulum lumen TAS extracellular matrix organization and biogenesis TAS lipopolysaccharide biosynthetic process IEA procollagen galactosyltransferase activity IEA Procollagen galactosyltransferase 2; 2.4.1.50; Glycosyltransferase 25 family member 2; Hydroxylysine galactosyltransferase 2; Precursor 11318611 15489334 16710414 16959974 19075007 21269460 9628581 NA GT252 -1 Procollagen galactosyltransferase 2 2.4.1.50 Glycosyltransferase 25 family member 2 Hydroxylysine galactosyltransferase 2 Precursor gene 1291 0.106951875741358 AMOTL2 C - Cellular Fate and Organization apical plasma membrane IEA tight junction IEA cytoplasmic vesicle IEA cytosol TAS Wnt receptor signaling pathway IEA Angiomotin-like protein 2; Leman coiled-coil protein; LCCP 10231032 12406577 14702039 15489334 16641997 17293535 20068231 21937427 22362771 NA AMOL2 -1 Angiomotin-like protein 2 Leman coiled-coil protein LCCP gene 1291 0.0617358293036639 RCAN2 C - Cellular Fate and Organization calcium-mediated signaling IEA central nervous system development NAS protein phosphatase 2B binding NAS nucleotide binding IEA Calcipressin-2; Down syndrome candidate region 1-like 1; Myocyte-enriched calcineurin-interacting protein 2; MCIP2; Regulator of calcineurin 2; Thyroid hormone-responsive protein ZAKI-4 12102656 14574404 14702039 8662924 NA RCAN2 -1 Calcipressin-2 Down syndrome candidate region 1-like 1 Myocyte-enriched calcineurin-interacting protein 2 MCIP2 Regulator of calcineurin 2 Thyroid hormone-responsive protein ZAKI-4 gene 1291 0.239033995593941 RCAN1 C - Cellular Fate and Organization cytoplasm IEA nucleus TAS signal transduction TAS response to estrogen stimulus IEA calcium-mediated signaling IEA negative regulation of smooth muscle cell differentiation IEA circulation TAS skeletal muscle fiber development IEA regulation of phosphoprotein phosphatase activity IEA central nervous system development TAS response to mechanical stimulus IEA transcription factor activity TAS DNA binding TAS Calcipressin-1; Adapt78; Down syndrome critical region protein 1; Myocyte-enriched calcineurin-interacting protein 1; MCIP1; Regulator of calcineurin 1 10830953 10861295 12809556 14702039 15489334 15935327 8595418 9325060 NA RCAN1 -1 Calcipressin-1 Adapt78 Down syndrome critical region protein 1 Myocyte-enriched calcineurin-interacting protein 1 MCIP1 Regulator of calcineurin 1 gene 1291 6.70900233782731E-4 SCRIB D - Genome Maintenance basolateral plasma membrane IEA cell-cell adherens junction IDA plasma membrane IDA synaptic vesicle targeting IEA positive regulation of apoptosis IMP cell proliferation IDA establishment of apical/basal cell polarity IMP neural tube closure IMP synaptic vesicle endocytosis IEA positive chemotaxis IMP cell-cell adhesion IGI asymmetric protein localization IEA cell migration IMP negative regulation of progression through mitotic cell cycle IDA virus-host interaction IEA wound healing IEA positive regulation of receptor recycling IMP Protein scribble homolog; Scribble; hScrib; Protein LAP4 11027293 12168954 15144186 15182672 15489334 15649318 15775968 15806148 15975580 16137684 16344308 16421571 16611247 16965391 17081983 18042258 18220336 18641685 18669648 18716323 19041750 19369195 19555689 19690332 20068231 21269460 21406692 22095531 8590280 NA SCRIB 1 Protein scribble homolog Scribble hScrib Protein LAP4 gene 1291 0.172836979987125 CEP55 D - Genome Maintenance centrosome IDA centriole IEA midbody IDA cleavage furrow IEA intercellular bridge IEA cytokinesis IGI mitosis IEA Centrosomal protein of 55 kDa; Cep55; Up-regulated in colon cancer 6 14702039 15164054 15489334 16198290 16406728 17081983 17556548 17853893 17974005 18669648 18691976 18948538 19690332 20068231 21269460 21406692 NA CEP55 1 Centrosomal protein of 55 kDa Cep55 Up-regulated in colon cancer 6 gene 1291 5.10247191475308E-4 GLRX N - Not Matched mitochondrion IEA nucleus IEA cytosol TAS nucleobase, nucleoside and nucleotide interconversion TAS cell redox homeostasis IEA protein disulfide oxidoreductase activity IEA electron carrier activity IEA glutathione disulfide oxidoreductase activity TAS Glutaredoxin-1; Thioltransferase-1; TTase-1 11222536 14702039 15489334 21269460 7851394 8018729 8019414 8645179 9332366 9677297 9860827 NA GLRX1 -1 Glutaredoxin-1 Thioltransferase-1 TTase-1 gene 1291 0.0244174348753505 FAM220A N - Not Matched nucleus IEA Protein FAM220A; STAT3-interacting protein as a repressor 12853948 14702039 15489334 NA F220A 1 Protein FAM220A STAT3-interacting protein as a repressor gene 1291 0.196900869837261 PEG3 T - Transcription intracellular IEA cytoplasm IDA nucleus IDA body growth IEA apoptosis IEA viral reproduction IEA embryonic development (sensu Mammalia) IEA transcription factor activity IEA zinc ion binding IEA nucleic acid binding IEA Paternally-expressed gene 3 protein; Zinc finger and SCAN domain-containing protein 24 11260267 11331620 11677152 14702039 15489334 16959974 17974005 21269460 9149948 NA PEG3 -1 Paternally-expressed gene 3 protein Zinc finger and SCAN domain-containing protein 24 gene 1291 0.0914604721306057 KPNA2 D - Genome Maintenance nucleoplasm TAS cytosol TAS G2 phase of mitotic cell cycle TAS virus-host interaction IEA cytokine and chemokine mediated signaling pathway TAS DNA metabolic process TAS regulation of DNA recombination TAS M phase specific microtubule process TAS NLS-bearing substrate import into nucleus IDA protein transporter activity IEA nuclear localization sequence binding IDA Importin subunit alpha-2; Karyopherin subunit alpha-2; RAG cohort protein 1; SRP1-alpha 10353244 10980193 11735022 11840567 11882654 15489334 15942031 16188882 16964243 17081983 18220336 18669648 18691976 19386897 19690332 20068231 21269460 21385873 21406692 21454664 7604027 7754385 8016130 8617227 9323134 9463369 9786944 NA IMA2 1 Importin subunit alpha-2 Karyopherin subunit alpha-2 RAG cohort protein 1 SRP1-alpha gene 1291 4.58870887597033E-4 CDKN3 D - Genome Maintenance perinuclear region IDA G1/S transition of mitotic cell cycle TAS negative regulation of cell proliferation TAS cell cycle arrest IDA regulation of cyclin-dependent protein kinase activity TAS protein serine/threonine phosphatase activity IDA protein tyrosine/serine/threonine phosphatase activity TAS protein tyrosine phosphatase activity IDA Cyclin-dependent kinase inhibitor 3; 3.1.3.16; 3.1.3.48; CDK2-associated dual-specificity phosphatase; Cyclin-dependent kinase interactor 1; Cyclin-dependent kinase-interacting protein 2; Kinase-associated phosphatase 10669749 10987270 11463386 11781350 12745075 15489334 15671017 7569954 8127873 8242750 NA CDKN3 1 Cyclin-dependent kinase inhibitor 3 3.1.3.16 3.1.3.48 CDK2-associated dual-specificity phosphatase Cyclin-dependent kinase interactor 1 Cyclin-dependent kinase-interacting protein 2 Kinase-associated phosphatase gene 1291 0.0526153778724936 N - Not Matched cytoplasm IDA nuclear membrane IEA lateral plasma membrane IEA apicolateral plasma membrane IEA neurite development IEA establishment and/or maintenance of epithelial cell polarity IEA zinc ion binding IEA Prickle-like protein 2; Precursor 12525887 15489334 17411337 17974005 21276947 NA PRIC2 -1 Prickle-like protein 2 Precursor gene 1291 0.00192483829616325 OSTM1 N - Not Matched integral to membrane IEA lysosomal membrane IEA cytosol IEA osteoclast differentiation IEA Osteopetrosis-associated transmembrane protein 1; Chloride channel 7 beta subunit; Precursor 11042152 12079282 12627228 12975309 14574404 14702039 15489334 16813530 17081983 18669648 19690332 20068231 21406692 21527911 NA OSTM1 -1 Osteopetrosis-associated transmembrane protein 1 Chloride channel 7 beta subunit Precursor gene 1291 3.39594595387442E-4 N - Not Matched cytoplasm IEA plasma membrane IDA stereocilium IEA apical part of cell IEA filopodium IEA cytoskeleton IEA ruffle IEA cleavage furrow IEA lamellipodium IEA extrinsic to membrane IEA microvillus biogenesis IEA apical protein localization IEA actin filament capping IEA Radixin 15489334 16554811 17226784 21269460 8486357 9430655 NA RADI -1 Radixin gene 1291 0.171241071829117 PDZD2 C - Cellular Fate and Organization endoplasmic reticulum ISS intercellular junction ISS extracellular region ISS nucleus ISS cell adhesion IEA PDZ domain-containing protein 2; Activated in prostate cancer protein; PDZ domain-containing protein 3; Processed PDZ domain-containing protein 2 11289102 9205841 NA PDZD2 -1 PDZ domain-containing protein 2 Activated in prostate cancer protein PDZ domain-containing protein 3 Processed PDZ domain-containing protein 2 gene 1291 0.0525502643359139 KCNK3 A - Transport and Sensing integral to plasma membrane TAS brain development IEA response to drug IEA reduction of cytosolic calcium ion concentration IEA synaptic transmission TAS potassium channel activity TAS open rectifier potassium channel activity IEA Potassium channel subfamily K member 3; Acid-sensitive potassium channel protein TASK-1; TWIK-related acid-sensitive K(+) channel 1; Two pore potassium channel KT3.1; Two pore K(+) channel KT3.1 10321245 10748056 11680614 15815621 9312005 NA KCNK3 -1 Potassium channel subfamily K member 3 Acid-sensitive potassium channel protein TASK-1 TWIK-related acid-sensitive K(+) channel 1 Two pore potassium channel KT3.1 Two pore K(+) channel KT3.1 gene 1291 0.231217754221989 KCNK1 A - Transport and Sensing apical plasma membrane IEA voltage-gated potassium channel complex TAS brush border membrane IEA endosome IEA synaptic transmission TAS response to nicotine IEA inward rectifier potassium channel activity TAS Potassium channel subfamily K member 1; Inward rectifying potassium channel protein TWIK-1; Potassium channel KCNO1 15489334 16710414 22282804 8605869 9362344 9462864 NA KCNK1 1 Potassium channel subfamily K member 1 Inward rectifying potassium channel protein TWIK-1 Potassium channel KCNO1 gene 1291 0.0143097055158031 IQSEC1 C - Cellular Fate and Organization cytoplasm IEA cell junction IDA nucleolus IDA actin cytoskeleton organization and biogenesis IBA regulation of ARF protein signal transduction IEA ARF guanyl-nucleotide exchange factor activity IBA phospholipid binding IEA IQ motif and SEC7 domain-containing protein 1; ADP-ribosylation factors guanine nucleotide-exchange protein 100; ADP-ribosylation factors guanine nucleotide-exchange protein 2; Brefeldin-resistant Arf-GEF 2 protein 11226253 15489334 16461286 18669648 19690332 21269460 21406692 9872452 NA IQEC1 -1 IQ motif and SEC7 domain-containing protein 1 ADP-ribosylation factors guanine nucleotide-exchange protein 100 ADP-ribosylation factors guanine nucleotide-exchange protein 2 Brefeldin-resistant Arf-GEF 2 protein gene 1291 0.00896578061676545 PMP22 C - Cellular Fate and Organization plasma membrane IEA compact myelin IEA tight junction IEA integral to membrane IEA negative regulation of cell proliferation IEA peripheral nervous system development TAS synaptic transmission TAS myelin formation IEA Peripheral myelin protein 22; PMP-22; Growth arrest-specific protein 3; GAS-3 10211478 10330345 10489052 10632107 10663978 10737979 11140841 11438991 11835375 12090401 12402337 12439896 12497641 12578939 12796555 1303210 1303228 1303281 1497668 15099592 15205993 15489334 16437560 21827951 7518101 7675244 7728152 7762451 8252046 8275092 8482547 8510709 8615087 8655153 8777804 8988161 8995589 9004143 9040744 9055797 9187667 9452053 9452099 9544841 9585367 9633821 9748013 9888385 NA PMP22 -1 Peripheral myelin protein 22 PMP-22 Growth arrest-specific protein 3 GAS-3 gene 1291 0.110807554138766 IRAK1 C - Cellular Fate and Organization lipid particle ISS interleukin-1 receptor complex NAS nucleus IEA endosome membrane TAS cytosol TAS nerve growth factor receptor signaling pathway TAS activation of NF-kappaB-inducing kinase IDA JNK cascade TAS inhibition of NF-kappaB transcription factor IMP protein oligomerization IMP positive regulation of smooth muscle cell proliferation IEA activation of MAPK activity TAS regulation of cytokine and chemokine mediated signaling pathway IMP Toll signaling pathway TAS activation of NF-kappaB transcription factor IDA protein amino acid autophosphorylation NAS MyD88-dependent toll-like receptor signaling pathway TAS innate immune response TAS positive regulation of transcription from RNA polymerase II promoter IEA transmembrane receptor protein serine/threonine kinase signaling pathway NAS response to peptidoglycan IEA positive regulation of transcription, DNA-dependent NAS positive regulation of I-kappaB kinase/NF-kappaB cascade TAS lipopolysaccharide-mediated signaling pathway IMP NF-kappaB-inducing kinase activity TAS ubiquitin-protein ligase activity TAS ATP binding IEA protein homodimerization activity NAS Interleukin-1 receptor-associated kinase 1; IRAK-1; 2.7.11.1 10723722 10854325 11397809 11960013 12496252 12538665 12860405 12874243 14625308 14684752 15084582 15465816 15489334 15767370 15772651 16024789 16286016 16690127 16951688 17344846 17890055 17997719 18347055 18669648 18691976 19022706 19675569 20400509 21269460 8599092 9430229 NA IRAK1 1 Interleukin-1 receptor-associated kinase 1 IRAK-1 2.7.11.1 gene 1291 0.0257419865106196 CARD8 C - Cellular Fate and Organization cytoplasm IDA nucleus IDA positive regulation of interleukin-1 beta secretion IDA negative regulation of I-kappaB kinase/NF-kappaB cascade IDA caspase activator activity IDA protein homodimerization activity IDA Caspase recruitment domain-containing protein 8; Apoptotic protein NDPP1; CARD-inhibitor of NF-kappa-B-activating ligand; CARDINAL; DACAR; Tumor up-regulated CARD-containing antagonist of CASP9; TUCAN 10231032 11408476 11551959 11821383 11956601 12067710 14702039 15030775 15057824 15489334 18212821 NA CARD8 -1 Caspase recruitment domain-containing protein 8 Apoptotic protein NDPP1 CARD-inhibitor of NF-kappa-B-activating ligand CARDINAL DACAR Tumor up-regulated CARD-containing antagonist of CASP9 TUCAN gene 1291 0.17273753523313 FHL5 T - Transcription nucleus IEA positive regulation of transcription from RNA polymerase II promoter IEA transcription coactivator activity IEA zinc ion binding IEA Four and a half LIM domains protein 5; FHL-5; Activator of cAMP-responsive element modulator in testis; Activator of CREM in testis 11327716 14574404 14702039 15489334 NA FHL5 -1 Four and a half LIM domains protein 5 FHL-5 Activator of cAMP-responsive element modulator in testis Activator of CREM in testis gene 1291 0.308617760461342 R - Stress and Defence cytosol IDA response to toxin IEA amine metabolic process IDA methylation IEA methyltransferase activity IEA thioether S-methyltransferase activity IEA amine N-methyltransferase activity IDA Indolethylamine N-methyltransferase; Indolamine N-methyltransferase; 2.1.1.49; 2.1.1.96; Aromatic alkylamine N-methyltransferase; Amine N-methyltransferase; Arylamine N-methyltransferase; Thioether S-methyltransferase; TEMT 10552930 12853948 14702039 15014171 15489334 NA INMT -1 Indolethylamine N-methyltransferase Indolamine N-methyltransferase 2.1.1.49 2.1.1.96 Aromatic alkylamine N-methyltransferase Amine N-methyltransferase Arylamine N-methyltransferase Thioether S-methyltransferase TEMT gene 1291 0.00341877596436688 XPC D - Genome Maintenance cytoplasm IDA nucleoplasm TAS response to UV-B IEA intra-S DNA damage checkpoint IEA response to drug IEA cell cycle checkpoint IMP nucleotide-excision repair, DNA damage recognition IDA nucleotide-excision repair, DNA damage removal TAS damaged DNA binding IDA loop DNA binding TAS single-stranded DNA binding IDA bubble DNA binding TAS DNA repair protein complementing XP-C cells; Xeroderma pigmentosum group C-complementing protein; p125 10447254 10734143 10766188 10873465 11279143 12505994 12509233 12509299 12547395 1461286 1522891 15489334 15882621 15964821 16533048 16627479 16641997 17081983 17355181 17487921 17525332 17682058 17897675 18220336 18318008 18669648 18682493 19609301 19690332 19941824 20028083 20068231 20649465 20798892 21406692 8168482 8298653 8692695 9372924 9734359 NA XPC -1 DNA repair protein complementing XP-C cells Xeroderma pigmentosum group C-complementing protein p125 gene 1291 0.00551430130139407 FHL1 C - Cellular Fate and Organization cytoplasm IDA plasma membrane IDA nucleus IDA cytosol IEA negative regulation of cell growth IDA muscle development NAS organ morphogenesis NAS positive regulation of potassium ion transport IDA cell differentiation IEA zinc ion binding IEA Four and a half LIM domains protein 1; FHL-1; Skeletal muscle LIM-protein 1; SLIM; SLIM-1 10352231 10480922 10524257 11400158 12665801 14702039 15489334 15772651 18179888 18179901 18274675 19608861 21269460 7626119 8753811 9714789 NA FHL1 -1 Four and a half LIM domains protein 1 FHL-1 Skeletal muscle LIM-protein 1 SLIM SLIM-1 gene 1291 0.00252767224368014 N - Not Matched mitochondrion IEA nitrogen compound metabolic process IEA nitrilase activity TAS Nitrilase homolog 1; 3.5.-.- 15489334 16710414 21269460 9671749 NA NIT1 1 Nitrilase homolog 1 3.5.-.- gene 1291 0.0218918562607483 M - Other Metabolism mitochondrion IEA sarcolemma IEA ATP-sensitive potassium channel complex IEA voltage-gated potassium channel complex TAS myofibril IEA heart development IEA defense response to virus IEA kidney development IEA vasodilation IEA response to lipopolysaccharide IEA synaptic transmission TAS potassium ion import IEA response to exogenous dsRNA IEA response to pH IEA inward rectifier potassium channel activity TAS ATP-activated inward rectifier potassium channel activity IEA ATP binding IEA ATP-sensitive inward rectifier potassium channel 8; Inward rectifier K(+) channel Kir6.1; Potassium channel, inwardly rectifying subfamily J member 8; uKATP-1 15489334 20153265 20558321 21836131 8595887 9573340 NA IRK8 -1 ATP-sensitive inward rectifier potassium channel 8 Inward rectifier K(+) channel Kir6.1 Potassium channel, inwardly rectifying subfamily J member 8 uKATP-1 gene 1315 0.062979595093097 ALDOA E - Energy Production platelet alpha granule lumen TAS actin cytoskeleton IDA cytosol TAS I band TAS ATP biosynthetic process IMP fructose 1,6-bisphosphate metabolic process IDA protein homotetramerization ISS regulation of cell shape IDA platelet degranulation TAS gluconeogenesis TAS striated muscle contraction IMP platelet activation TAS actin filament organization TAS glycolysis IMP muscle maintenance IMP fructose metabolic process IMP fructose-bisphosphate aldolase activity IDA tubulin binding TAS actin binding TAS identical protein binding TAS Fructose-bisphosphate aldolase A; 4.1.2.13; Lung cancer antigen NY-LU-1; Muscle-type aldolase 10048322 12665801 1353685 14615364 14702039 14766013 15489334 17081983 18669648 19608861 19690332 1999195 20068231 2056525 21269460 21406692 21908771 2229018 2335208 2825199 3030757 3355497 3391172 3441006 3674018 3840020 6696436 8598869 NA ALDOA 1 Fructose-bisphosphate aldolase A 4.1.2.13 Lung cancer antigen NY-LU-1 Muscle-type aldolase gene 1291 0.265873318267263 AAMDC C - Cellular Fate and Organization cytoplasm ISS negative regulation of apoptosis IEA positive regulation of fat cell differentiation IEA Mth938 domain-containing protein; Adipogenesis associated Mth938 domain-containing protein 14702039 15489334 16554811 17850744 21269460 NA AAMDC -1 Mth938 domain-containing protein Adipogenesis associated Mth938 domain-containing protein gene 1291 0.0850964838047879 CD300LG N - Not Matched basolateral plasma membrane IEA apical plasma membrane IEA integral to membrane IEA CMRF35-like molecule 9; CLM-9; CD300 antigen-like family member G; Triggering receptor expressed on myeloid cells 4; TREM-4; CD300g; Precursor 12975309 14702039 15340161 15489334 16625196 16876123 NA CLM9 -1 CMRF35-like molecule 9 CLM-9 CD300 antigen-like family member G Triggering receptor expressed on myeloid cells 4 TREM-4 CD300g Precursor gene 1291 0.00896578061676545 LPHN2 A - Transport and Sensing plasma membrane IEA integral to membrane NAS neuropeptide signaling pathway IEA G-protein coupled receptor activity TAS latrotoxin receptor activity NAS carbohydrate binding IEA Latrophilin-2; Calcium-independent alpha-latrotoxin receptor 2; CIRL-2; Latrophilin homolog 1; Lectomedin-1; Precursor 10030676 10760572 16710414 17456239 19159218 21269460 21406692 9872452 NA LPHN2 -1 Latrophilin-2 Calcium-independent alpha-latrotoxin receptor 2 CIRL-2 Latrophilin homolog 1 Lectomedin-1 Precursor gene 1291 0.00525668008115833 TLE4 C - Cellular Fate and Organization nucleoplasm TAS Notch signaling pathway TAS negative regulation of transcription from RNA polymerase II promoter IEA Wnt receptor signaling pathway IEA chromatin binding IEA RNA polymerase II transcription factor activity, enhancer binding IEA transcription corepressor activity IEA Transducin-like enhancer protein 4 10574462 1303260 15164053 15489334 17081983 17974005 18669648 19608861 19690332 21406692 22304967 NA TLE4 -1 Transducin-like enhancer protein 4 gene 1291 0.0550793834643225 DSG2 C - Cellular Fate and Organization desmosome IEA plasma membrane IDA intercellular junction TAS integral to membrane IEA cell adhesion IDA homophilic cell adhesion IEA cell structure disassembly during apoptosis TAS calcium ion binding IEA Desmoglein-2; Cadherin family member 5; HDGC; Precursor 12754519 15489334 16335952 16773573 17081983 18669648 18678517 18691976 19159218 19349973 1935985 19690332 19863551 20031617 20068231 21062920 21269460 21406692 8143788 NA DSG2 1 Desmoglein-2 Cadherin family member 5 HDGC Precursor gene 1291 0.0385082947407456 ARHGAP31 C - Cellular Fate and Organization focal adhesion IEA lamellipodium IEA cytosol TAS regulation of small GTPase mediated signal transduction TAS small GTPase mediated signal transduction TAS GTPase activator activity IEA Rho GTPase-activating protein 31; Cdc42 GTPase-activating protein 10574462 12192056 15489334 16519628 16641997 21565175 21565291 NA RHG31 -1 Rho GTPase-activating protein 31 Cdc42 GTPase-activating protein gene 1291 0.0747763912235243 PDLIM2 N - Not Matched cytoplasm IEA cell surface IDA nucleus IEA actin cytoskeleton IDA focal adhesion IDA zinc ion binding IEA PDZ and LIM domain protein 2; PDZ-LIM protein mystique 11214971 14702039 15489334 15498874 15659642 19690332 NA PDLI2 -1 PDZ and LIM domain protein 2 PDZ-LIM protein mystique gene 1291 0.00556253733701826 PDLIM1 T - Transcription transcription factor complex IEA cytoplasm IEA cytoskeleton IEA response to hypoxia IEA regulation of transcription, DNA-dependent IEA response to oxidative stress TAS transcription coactivator activity IEA zinc ion binding IEA PDZ and LIM domain protein 1; C-terminal LIM domain protein 1; Elfin; LIM domain protein CLP-36 10022510 10753915 10861853 11110697 12665801 14702039 15144186 15164054 15489334 15592455 17924679 18088087 18669648 19690332 20068231 21269460 21406692 NA PDLI1 -1 PDZ and LIM domain protein 1 C-terminal LIM domain protein 1 Elfin LIM domain protein CLP-36 gene 1291 0.00210659302119923 A - Transport and Sensing perinuclear region IEA early endosome membrane IEA SNARE complex IBA integral to membrane IEA post-Golgi vesicle-mediated transport TAS intracellular protein transport IBA synaptic vesicle exocytosis IBA SNAP receptor activity IBA SNARE binding IBA Syntaxin-7 10564279 10692457 12665801 14574404 15489334 18669648 19690332 21269460 21406692 9358037 NA STX7 -1 Syntaxin-7 gene 1291 0.0816080920104172 METTL7A N - Not Matched lipid particle IEA membrane IEA endoplasmic reticulum IEA methyltransferase activity IEA Methyltransferase-like protein 7A; 2.1.1.-; Protein AAM-B; Precursor 12975309 14702039 15489334 17974005 18477614 19773358 21269460 NA MET7A -1 Methyltransferase-like protein 7A 2.1.1.- Protein AAM-B Precursor gene 1291 0.0550793834643225 C - Cellular Fate and Organization desmosome IEA intercellular junction TAS nucleus IEA cell adhesion IEA Plakophilin-3 10374265 10381383 15489334 16964243 18669648 18691976 19369195 20068231 21269460 21406692 NA PKP3 1 Plakophilin-3 gene 1291 0.00298781153961145 MEN1 D - Genome Maintenance histone methyltransferase complex IDA chromatin IDA cleavage furrow IDA nuclear matrix IDA cytosol IDA negative regulation of telomerase activity IMP transcription initiation from RNA polymerase II promoter TAS negative regulation of cell proliferation IDA negative regulation of cyclin-dependent protein kinase activity IMP embryonic skeletal morphogenesis IEA negative regulation of transcription factor activity IDA positive regulation of protein binding IDA negative regulation of JNK cascade IDA MAPKKK cascade IDA positive regulation of transcription from RNA polymerase II promoter TAS palate development IEA positive regulation of cell division IEA transforming growth factor beta receptor signaling pathway TAS chromatin remodeling IEA cell cycle arrest IEA response to UV IDA leukocyte homeostasis IEA positive regulation of transforming growth factor beta receptor signaling pathway IMP negative regulation of organ size IEA hemopoiesis IEA positive regulation of apoptosis IEA osteoblast fate commitment IEA negative regulation of transcription from RNA polymerase II promoter IDA positive regulation of caspase activity IEA positive regulation of osteoblast differentiation IEA negative regulation of osteoblast differentiation IGI DNA repair NAS osteoblast development IGI brain development IEA positive regulation of histone methylation IEA four-way junction DNA binding IDA sequence-specific DNA binding IEA double-stranded DNA binding IDA chromatin binding IEA Y-form DNA binding IDA protein binding, bridging IDA Menin 10090472 10229909 10534569 10576763 10617276 10634381 10647896 10660339 10664520 10664521 10849016 10993647 11034102 11102994 11134142 11241849 11274402 11526476 12016470 12050235 12112656 12417605 12652570 12699448 12746426 12791038 12837246 12874027 14686752 14992727 15199122 15205994 15374998 15489334 15714081 15730416 16554811 17500065 17525332 17555499 17555500 18669648 19690332 20068231 9103196 9215689 9215690 9241276 9463336 9506756 9671267 9683585 9709921 9709976 9709985 9740255 9747036 9792884 9820618 9832038 9843042 9888389 9989505 NA MEN1 1 Menin gene 1291 0.00231151180858288 F - Protein Fate protein folding IEA social behavior IEP DnaJ homolog subfamily C member 9; DnaJ protein SB73 14702039 18669648 19690332 20068231 21269460 NA DNJC9 1 DnaJ homolog subfamily C member 9 DnaJ protein SB73 gene 1291 0.0359059239895385 STX2 C - Cellular Fate and Organization basolateral plasma membrane IDA cell surface IEA intercellular junction IEA lipid raft IEA integral to membrane IEA cytoplasmic vesicle IEA intracellular membrane-bound organelle TAS signal transduction TAS organ morphogenesis TAS acrosome reaction ISS ectoderm development TAS intracellular protein transport IEA cell differentiation IEA calcium-dependent protein binding ISS Syntaxin-2; Epimorphin 15489334 16541075 8466509 NA STX2 -1 Syntaxin-2 Epimorphin gene 1291 0.0457785783868501 ADARB1 D - Genome Maintenance nucleolus IDA nucleus IDA nucleoplasm TAS mRNA processing IEA RNA processing IDA negative regulation of cell migration IDA defense response to virus IEA negative regulation of cell proliferation IDA mRNA modification TAS base conversion or substitution editing IC innate immune response IEA regulation of cell cycle IDA adenosine to inosine editing IDA positive regulation of viral genome replication IMP double-stranded RNA binding IDA double-stranded RNA adenosine deaminase activity IDA adenosine deaminase activity IEA RNA binding IDA mRNA binding TAS metal ion binding IEA Double-stranded RNA-specific editase 1; 3.5.-.-; RNA-editing deaminase 1; RNA-editing enzyme 1; dsRNA adenosine deaminase 10830953 12459255 14759258 16141067 16297572 18178553 18669648 19156214 19690332 19908260 20068231 20192758 21182352 21211811 21289159 21769729 22022963 22113393 22988838 9111310 9143496 9149227 9330641 NA RED1 -1 Double-stranded RNA-specific editase 1 3.5.-.- RNA-editing deaminase 1 RNA-editing enzyme 1 dsRNA adenosine deaminase gene 1291 0.122062164231375 ASPA N - Not Matched cytoplasm IDA nucleus IEA aspartate catabolic process TAS myelination in the central nervous system IEA positive regulation of oligodendrocyte differentiation IEA aspartoacylase activity IEA hydrolase activity, acting on ester bonds IEA aminoacylase activity TAS metal ion binding IEA Aspartoacylase; 3.5.1.15; Aminoacylase-2; ACY-2 10407784 10564886 10909858 12205125 12638939 12706335 15489334 17027983 17194761 18293939 7599639 7668285 8023850 8252036 8659549 9452117 NA ACY2 -1 Aspartoacylase 3.5.1.15 Aminoacylase-2 ACY-2 gene 1846 1.0 POU2F1 T - Transcription nucleoplasm TAS negative regulation of transcription, DNA-dependent IDA transcription from RNA polymerase III promoter TAS sequence-specific DNA binding IDA transcription factor activity TAS POU domain, class 2, transcription factor 1; NF-A1; Octamer-binding protein 1; Oct-1; Octamer-binding transcription factor 1; OTF-1 10480874 10629049 12663137 12826401 14612514 14702039 15489334 16710414 1684878 16959974 16964243 18669648 20068231 21269460 21406692 2905684 7663141 8156594 8462099 8479524 NA PO2F1 0 POU domain, class 2, transcription factor 1 NF-A1 Octamer-binding protein 1 Oct-1 Octamer-binding transcription factor 1 OTF-1 TF 1291 0.00458201074186734 ARHGAP29 C - Cellular Fate and Organization cytosol TAS Rho protein signal transduction TAS Rho GTPase activator activity TAS metal ion binding IEA Rho GTPase-activating protein 29; PTPL1-associated RhoGAP protein 1; Rho-type GTPase-activating protein 29 11716068 15489334 15752761 16710414 16959974 17081983 17488656 18669648 20068231 9305890 NA RHG29 -1 Rho GTPase-activating protein 29 PTPL1-associated RhoGAP protein 1 Rho-type GTPase-activating protein 29 gene 1291 0.106951875741358 ARHGAP24 C - Cellular Fate and Organization plasma membrane IDA cell projection IEA cytoskeleton IEA focal adhesion IEA cytosol TAS positive regulation of GTPase activity IEA regulation of small GTPase mediated signal transduction TAS small GTPase mediated signal transduction TAS angiogenesis IEA cell differentiation IEA phospholipid binding IEA GTPase activator activity IEA Rho GTPase-activating protein 24; Filamin-A-associated RhoGAP; FilGAP; RAC1- and CDC42-specific GTPase-activating protein of 72 kDa; RC-GAP72; Rho-type GTPase-activating protein 24; RhoGAP of 73 kDa; Sarcoma antigen NY-SAR-88; p73RhoGAP 11230166 12601173 14702039 15254788 15302923 15489334 15611138 16862148 NA RHG24 -1 Rho GTPase-activating protein 24 Filamin-A-associated RhoGAP FilGAP RAC1- and CDC42-specific GTPase-activating protein of 72 kDa RC-GAP72 Rho-type GTPase-activating protein 24 RhoGAP of 73 kDa Sarcoma antigen NY-SAR-88 p73RhoGAP gene 1291 1.0 FOXP3 D - Genome Maintenance transcription factor complex IBA cytoplasm IBA nucleus NAS regulation of isotype switching to IgG isotypes IBA T cell receptor signaling pathway IBA pattern specification process IBA positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IBA positive regulation of interleukin-4 production IEA B cell homeostasis IBA negative regulation of interleukin-10 production IDA negative regulation of interleukin-6 production IBA tolerance induction to self antigen IBA negative regulation of interleukin-5 production IBA negative regulation of activated T cell proliferation NAS negative regulation of interleukin-4 production IDA inhibition of CREB transcription factor IDA embryonic development IBA negative regulation of isotype switching to IgE isotypes IBA post-embryonic development IBA cytokine production IEA negative regulation of histone acetylation IBA negative regulation of cytokine secretion IDA positive regulation of histone acetylation IMP negative regulation of interferon-gamma biosynthetic process IBA negative regulation of chronic inflammatory response IBA positive regulation of transcription from RNA polymerase II promoter IMP CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IEA chromatin remodeling NAS T cell homeostasis NAS myeloid cell homeostasis IBA negative regulation of interferon-gamma production IDA negative regulation of interleukin-2 production IDA positive regulation of peripheral T cell tolerance induction IBA negative regulation of tumor necrosis factor-alpha production IBA negative regulation of T cell cytokine production IDA cerebellum development IBA inhibition of NF-kappaB transcription factor IDA response to virus IEP negative regulation of interleukin-2 biosynthetic process IMP T cell activation IDA negative regulation of histone deacetylation IGI positive regulation of T cell anergy IBA negative regulation of transcription, DNA-dependent IDA T cell mediated immunity IEA sequence-specific DNA binding IDA double-stranded DNA binding IBA NF-kappaB binding NAS protein heterodimerization activity IBA DNA bending activity IBA transcription corepressor activity IBA RNA polymerase II transcription factor activity, enhancer binding IBA chromatin binding IBA zinc ion binding IEA Forkhead box protein P3; Scurfin 11120765 11137992 11137993 11138001 11768393 15489334 15772651 20676092 22312127 NA FOXP3 0 Forkhead box protein P3 Scurfin TF 4626 1.0 FOXP1 D - Genome Maintenance transcription factor complex IBA cytoplasm IBA pattern specification process IBA lung development IEA sarcomere organization IEA positive regulation of mesenchymal cell proliferation IBA embryonic development IBA ventral spinal cord development IEA embryonic development (sensu Mammalia) IEA regulation of transcription factor activity IBA motor axon guidance IEA striated muscle development IBA positive regulation of immunoglobulin production IBA positive regulation of transcription from RNA polymerase II promoter IEA smooth muscle development IBA pre-B cell differentiation IBA cardiac muscle cell differentiation IBA negative regulation of transcription, DNA-dependent IDA sequence-specific DNA binding IEA double-stranded DNA binding IBA protein heterodimerization activity IBA DNA bending activity IBA RNA polymerase II transcription factor activity, enhancer binding IBA chromatin binding IBA zinc ion binding IEA protein homodimerization activity IBA transcription factor binding IBA Forkhead box protein P1 11042152 11751404 14702039 15489334 16641997 17344859 18220336 19352412 20848658 20950788 NA FOXP1 0 Forkhead box protein P1 TF 1291 0.182533419955059 RMDN3 C - Cellular Fate and Organization spindle pole IEA microtubule IEA nucleus IEA mitochondrial outer membrane IDA integral to membrane IEA calcium ion homeostasis IMP apoptosis IEA cell differentiation IEA Regulator of microtubule dynamics protein 3; RMD-3; hRMD-3; Cerebral protein 10; Protein FAM82A2; Protein FAM82C; Protein tyrosine phosphatase-interacting protein 51; TCPTP-interacting protein 51 12975309 14702039 15489334 15609043 16820967 17081983 17361080 18070910 18220336 18669648 18691976 19690332 20068231 21269460 21406692 22131369 NA RMD3 -1 Regulator of microtubule dynamics protein 3 RMD-3 hRMD-3 Cerebral protein 10 Protein FAM82A2 Protein FAM82C Protein tyrosine phosphatase-interacting protein 51 TCPTP-interacting protein 51 gene 1291 0.0359059239895385 SHANK3 A - Transport and Sensing cytoplasm IEA cell junction IEA postsynaptic membrane IEA postsynaptic density ISS negative regulation of cell volume ISS striatal medium spiny neuron differentiation ISS social behavior ISS positive regulation of synapse structural plasticity ISS positive regulation of synaptic transmission, glutamatergic ISS regulation of balance ISS memory ISS learning ISS positive regulation of long-term neuronal synaptic plasticity ISS brain morphogenesis ISS GKAP/Homer scaffold activity ISS ionotropic glutamate receptor binding ISS protein C-terminus binding ISS SH3 and multiple ankyrin repeat domains protein 3; Shank3; Proline-rich synapse-associated protein 2; ProSAP2 10591208 10806096 11258795 11431708 12504591 17173049 18088087 19690332 20385823 NA SHAN3 -1 SH3 and multiple ankyrin repeat domains protein 3 Shank3 Proline-rich synapse-associated protein 2 ProSAP2 gene 1398 1.0 D - Genome Maintenance SWI/SNF complex TAS PML body IDA Rb-E2F complex TAS spindle IEA chromatin TAS negative regulation of cell growth TAS G1/S transition checkpoint TAS negative regulation of epithelial cell proliferation IEA Ras protein signal transduction IEP negative regulation of smoothened signaling pathway IEA neuron apoptosis IEA enucleate erythrocyte differentiation IEA neurite development IEA negative regulation of transcription factor activity TAS S phase of mitotic cell cycle TAS G1/S-specific transcription in mitotic cell cycle TAS neuron morphogenesis during differentiation IEA positive regulation of transcription from RNA polymerase II promoter IEA myoblast differentiation IMP chromatin remodeling TAS cell cycle arrest TAS G1 phase of mitotic cell cycle TAS neuron maturation IEA positive regulation of mitotic metaphase/anaphase transition IMP regulation of lipid kinase activity IDA gut development IEA sister chromatid biorientation IMP positive regulation of macrophage differentiation IEA negative regulation of S phase of mitotic cell cycle TAS transcription, DNA-dependent IEA virus-host interaction IEA negative regulation of protein kinase activity IPI positive regulation of transcription, DNA-dependent NAS negative regulation of transcription, DNA-dependent IDA striated muscle cell differentiation IEA androgen receptor signaling pathway NAS cell division IEA transcription factor activity TAS transcription coactivator activity NAS androgen receptor binding NAS kinase binding IDA Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110 10409732 10446990 10499802 10671068 10779342 10869426 10888886 11223246 11484059 11524739 11571652 12450794 12466551 12475961 12682072 12695505 1316611 1352398 1352883 14702039 15057823 15084261 15489334 15538385 15542589 15803180 15809340 15927959 15949438 16214886 16337594 16360038 16645588 17380128 1756735 17974914 17996702 18220336 18669648 19608861 19690332 20068231 20870719 20940255 21269460 21406692 21952639 22787429 2594029 2701949 2717184 2839300 3413073 3480530 3657987 3823889 7525595 7704558 7795591 7881418 7902321 7927327 7935440 8114739 8346255 8414517 8605116 8776589 8892909 9140452 9145110 9311732 9495340 9858607 9973307 NA RB 0 Retinoblastoma-associated protein p105-Rb pRb Rb pp110 TF 1291 0.0107333449193607 ZEB2 C - Cellular Fate and Organization cytoplasm IDA nucleolus IDA hippocampus development IEA cell proliferation in the forebrain IEA somitogenesis IEA neural crest cell migration IEA neural tube closure IEA positive regulation of Wnt receptor signaling pathway IEA positive regulation of JNK activity IEA transcription, DNA-dependent IEA nervous system development NAS sequence-specific DNA binding IEA transcription factor activity IEA phosphatase regulator activity NAS zinc ion binding IEA SMAD binding NAS Zinc finger E-box-binding homeobox 2; Smad-interacting protein 1; SMADIP1; Zinc finger homeobox protein 1b 11279515 11448942 12451214 14702039 15384097 15489334 15815621 16061479 16688751 16959974 19608861 9628581 9853615 NA ZEB2 -1 Zinc finger E-box-binding homeobox 2 Smad-interacting protein 1 SMADIP1 Zinc finger homeobox protein 1b gene 1291 0.00503499461286295 ZEB1 C - Cellular Fate and Organization cytoplasm IDA nucleus IDA immune response TAS cell proliferation TAS positive regulation of neuron differentiation ISS negative regulation of transcription from RNA polymerase II promoter TAS transcription, DNA-dependent IEA sequence-specific DNA binding IEA transcription factor activity TAS transcription corepressor activity TAS transcription coactivator activity TAS zinc ion binding TAS Zinc finger E-box-binding homeobox 1; NIL-2-A zinc finger protein; Negative regulator of IL2; Transcription factor 8; TCF-8 15164054 15489334 16061479 16252232 17081983 1840704 18669648 19690332 19935649 20036349 20068231 20175752 20418909 21269460 8138542 NA ZEB1 -1 Zinc finger E-box-binding homeobox 1 NIL-2-A zinc finger protein Negative regulator of IL2 Transcription factor 8 TCF-8 gene 1291 0.0261796027264088 SLC44A5 N - Not Matched plasma membrane TAS integral to membrane IEA phosphatidylcholine biosynthetic process TAS Choline transporter-like protein 5; Solute carrier family 44 member 5 14702039 15489334 15715662 16710414 NA CTL5 1 Choline transporter-like protein 5 Solute carrier family 44 member 5 gene 1291 0.214076169236591 N - Not Matched Golgi membrane TAS integral to membrane IEA O-glycan processing TAS polypeptide N-acetylgalactosaminyltransferase activity TAS N-acetylgalactosaminyltransferase 7; 2.4.1.-; Polypeptide GalNAc transferase 7; GalNAc-T7; pp-GaNTase 7; Protein-UDP acetylgalactosaminyltransferase 7; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7 10544240 15489334 16303743 21269460 NA GALT7 1 N-acetylgalactosaminyltransferase 7 2.4.1.- Polypeptide GalNAc transferase 7 GalNAc-T7 pp-GaNTase 7 Protein-UDP acetylgalactosaminyltransferase 7 UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7 gene 1291 0.00106232178122635 MELK D - Genome Maintenance plasma membrane IDA cell cortex IDA hemopoiesis ISS positive regulation of apoptosis ISS protein amino acid autophosphorylation IDA G2/M transition of mitotic cell cycle TAS apoptosis IDA protein serine/threonine kinase activity IEA calcium ion binding IDA non-membrane spanning protein tyrosine kinase activity IDA ATP binding IEA lipid binding IEA Maternal embryonic leucine zipper kinase; hMELK; 2.7.11.1; Protein kinase Eg3; pEg3 kinase; Protein kinase PK38; hPK38; Tyrosine-protein kinase MELK; 2.7.10.2 11802789 12400006 14699119 14702039 14976552 15164053 15489334 15908796 16159311 16216881 16266996 16628004 17081983 17280616 17344846 17722061 17960622 18669648 18691976 19369195 19671159 19690332 20420823 20861186 21145462 21558073 21806965 8724849 NA MELK 1 Maternal embryonic leucine zipper kinase hMELK 2.7.11.1 Protein kinase Eg3 pEg3 kinase Protein kinase PK38 hPK38 Tyrosine-protein kinase MELK 2.7.10.2 gene 1291 0.0525502643359139 DNAJB4 F - Protein Fate cytoplasm IDA plasma membrane IDA nucleus IDA response to unfolded protein TAS response to heat TAS protein folding IEA unfolded protein binding TAS DnaJ homolog subfamily B member 4; Heat shock 40 kDa protein 1 homolog; HSP40 homolog; Heat shock protein 40 homolog; Human liver DnaJ-like protein 14702039 15489334 15661747 16542645 18669648 18837411 20068231 21255413 21269460 9546042 NA DNJB4 -1 DnaJ homolog subfamily B member 4 Heat shock 40 kDa protein 1 homolog HSP40 homolog Heat shock protein 40 homolog Human liver DnaJ-like protein gene 1291 1.15745475909427E-4 A - Transport and Sensing endoplasmic reticulum membrane TAS integral to membrane IEA protein retention in ER IEA unfolded protein response, activation of signaling protein activity TAS protein transport IEA vesicle-mediated transport IEA ER retention sequence binding IEA ER lumen protein retaining receptor 3; KDEL endoplasmic reticulum protein retention receptor 3; KDEL receptor 3 10591208 12529303 14702039 15461802 15489334 NA ERD23 1 ER lumen protein retaining receptor 3 KDEL endoplasmic reticulum protein retention receptor 3 KDEL receptor 3 gene 2072 5.41764344545204E-5 DECR2 N - Not Matched peroxisomal membrane IEA fatty acid desaturation IDA 2,4-dienoyl-CoA reductase (NADPH) activity IDA trans-2-enoyl-CoA reductase (NADPH) activity IDA nucleotide binding IEA Peroxisomal 2,4-dienoyl-CoA reductase; pDCR; 1.3.1.34; 2,4-dienoyl-CoA reductase 2 11157797 11514237 14702039 15489334 15616553 19608861 22745130 NA DECR2 1 Peroxisomal 2,4-dienoyl-CoA reductase pDCR 1.3.1.34 2,4-dienoyl-CoA reductase 2 gene 1291 9.42399042257415E-6 SLC7A5 C - Cellular Fate and Organization apical plasma membrane IEA plasma membrane TAS integral to membrane IEA cytosol IEA amino acid metabolic process TAS blood coagulation TAS leukocyte migration TAS cell differentiation IEA nervous system development IEA peptide antigen binding ISS neutral amino acid transporter activity TAS L-amino acid transporter activity IEA Large neutral amino acids transporter small subunit 1; 4F2 light chain; 4F2 LC; 4F2LC; CD98 light chain; Integral membrane protein E16; L-type amino acid transporter 1; hLAT1; Solute carrier family 7 member 5; y+ system cationic amino acid transporter 10049700 10072483 10391915 10574970 11311135 11389679 11557028 11564694 11742812 12117417 12225859 12824232 15489334 15769744 1597461 16027961 16496379 18262359 18669648 18691976 18781797 19369195 20068231 21269460 21406692 9751058 NA LAT1 1 Large neutral amino acids transporter small subunit 1 4F2 light chain 4F2 LC 4F2LC CD98 light chain Integral membrane protein E16 L-type amino acid transporter 1 hLAT1 Solute carrier family 7 member 5 y+ system cationic amino acid transporter gene 1291 5.59962278657706E-4 KDELR1 A - Transport and Sensing Golgi cis face IEA ER-Golgi intermediate compartment IDA Golgi apparatus IEA endoplasmic reticulum membrane IEA integral to membrane TAS protein retention in ER IEA vesicle-mediated transport IEA intracellular protein transport TAS KDEL sequence binding TAS ER lumen protein retaining receptor 1; KDEL endoplasmic reticulum protein retention receptor 1; KDEL receptor 1; Putative MAPK-activating protein PM23 12761501 14702039 15489334 2172835 8392934 NA ERD21 1 ER lumen protein retaining receptor 1 KDEL endoplasmic reticulum protein retention receptor 1 KDEL receptor 1 Putative MAPK-activating protein PM23 gene 1291 4.46465071551715E-4 F - Protein Fate integral to Golgi membrane NAS perinuclear region IDA Golgi stack IDA extracellular region IEA protein amino acid O-linked glycosylation via serine IDA O-glycan processing TAS protein amino acid O-linked glycosylation via threonine IDA immunoglobulin biosynthetic process IDA polypeptide N-acetylgalactosaminyltransferase activity IDA manganese ion binding IDA Polypeptide N-acetylgalactosaminyltransferase 2; 2.4.1.41; Polypeptide GalNAc transferase 2; GalNAc-T2; pp-GaNTase 2; Protein-UDP acetylgalactosaminyltransferase 2; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2; Polypeptide N-acetylgalactosaminyltransferase 2 soluble form 12438318 14702039 15489334 16710414 21269460 7592619 9295285 9394011 NA GALT2 1 Polypeptide N-acetylgalactosaminyltransferase 2 2.4.1.41 Polypeptide GalNAc transferase 2 GalNAc-T2 pp-GaNTase 2 Protein-UDP acetylgalactosaminyltransferase 2 UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2 Polypeptide N-acetylgalactosaminyltransferase 2 soluble form gene 1291 0.0717638596053337 ZDHHC13 C - Cellular Fate and Organization Golgi-associated vesicle membrane ISS integral to membrane IEA positive regulation of I-kappaB kinase/NF-kappaB cascade IMP magnesium ion transporter activity ISS palmitoyltransferase activity ISS zinc ion binding IEA signal transducer activity IMP Palmitoyltransferase ZDHHC13; 2.3.1.-; Huntingtin-interacting protein 14-related protein; HIP14-related protein; Huntingtin-interacting protein HIP3RP; Putative MAPK-activating protein PM03; Putative NF-kappa-B-activating protein 209; Zinc finger DHHC domain-containing protein 13; DHHC-13 12393793 12761501 14702039 15489334 16554811 NA ZDH13 1 Palmitoyltransferase ZDHHC13 2.3.1.- Huntingtin-interacting protein 14-related protein HIP14-related protein Huntingtin-interacting protein HIP3RP Putative MAPK-activating protein PM03 Putative NF-kappa-B-activating protein 209 Zinc finger DHHC domain-containing protein 13 DHHC-13 gene 1291 0.00298781153961145 A - Transport and Sensing plasma membrane IDA mitochondrial matrix TAS mitochondrial inner membrane IEA aspartate biosynthetic process IEA glutamate metabolic process ISS 4-hydroxyproline catabolic process TAS aspartate catabolic process IDA response to ethanol IDA 2-oxoglutarate metabolic process ISS gluconeogenesis TAS oxaloacetate metabolic process IEA amino acid biosynthetic process TAS fatty acid transport IEP glutamate catabolic process to 2-oxoglutarate IEA glutamate catabolic process to aspartate IEA pyridoxal phosphate binding IEA kynurenine-oxoglutarate transaminase activity IEA aspartate transaminase activity IDA Aspartate aminotransferase, mitochondrial; mAspAT; 2.6.1.1; 2.6.1.7; Fatty acid-binding protein; FABP-1; Glutamate oxaloacetate transaminase 2; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynurenine--oxoglutarate transaminase IV; Plasma membrane-associated fatty acid-binding protein; FABPpm; Transaminase A; Precursor 15489334 15616553 19608861 21269460 3207426 4052435 9537447 NA AATM 1 Aspartate aminotransferase, mitochondrial mAspAT 2.6.1.1 2.6.1.7 Fatty acid-binding protein FABP-1 Glutamate oxaloacetate transaminase 2 Kynurenine aminotransferase 4 Kynurenine aminotransferase IV Kynurenine--oxoglutarate transaminase 4 Kynurenine--oxoglutarate transaminase IV Plasma membrane-associated fatty acid-binding protein FABPpm Transaminase A Precursor gene 1291 0.0051926145583678 N - Not Matched integral to membrane IEA Transmembrane protein C5orf28 14702039 15489334 NA CE028 1 Transmembrane protein C5orf28 gene 1291 9.49969283820029E-5 E - Energy Production cytosol TAS glycogen biosynthetic process TAS glucose metabolic process TAS glycogen catabolic process TAS glycogenin glucosyltransferase activity TAS Glycogenin-2; GN-2; GN2; 2.4.1.186 10721716 11840567 15489334 15772651 21248752 9346895 9857012 NA GLYG2 1 Glycogenin-2 GN-2 GN2 2.4.1.186 gene 1291 0.00415489084742234 SDCBP C - Cellular Fate and Organization melanosome IEA adherens junction NAS endoplasmic reticulum membrane IEA interleukin-5 receptor complex ISS nucleus NAS cytoskeleton NAS focal adhesion IEA cytosol TAS substrate-bound cell migration, cell extension NAS actin cytoskeleton organization and biogenesis NAS axon guidance TAS protein targeting to membrane NAS positive regulation of JNK cascade IC synaptic transmission NAS Ras protein signal transduction IEA positive regulation of phosphorylation IDA interleukin-5 receptor binding ISS syndecan binding NAS cytoskeletal adaptor activity NAS Syntenin-1; Melanoma differentiation-associated protein 9; MDA-9; Pro-TGF-alpha cytoplasmic domain-interacting protein 18; TACIP18; Scaffold protein Pbp1; Syndecan-binding protein 1 10230395 10770943 11179419 11432873 11498591 12643545 12679023 12842047 14702039 15081807 15489334 16421571 16533050 17081065 21269460 9391086 9511750 9883737 NA SDCB1 -1 Syntenin-1 Melanoma differentiation-associated protein 9 MDA-9 Pro-TGF-alpha cytoplasmic domain-interacting protein 18 TACIP18 Scaffold protein Pbp1 Syndecan-binding protein 1 gene 1391 0.0146035958550651 ASNS D - Genome Maintenance cytosol TAS negative regulation of apoptosis IMP response to methotrexate IEA response to toxin IEA response to mechanical stimulus IEA liver development IEA positive regulation of progression through mitotic cell cycle IDA response to light stimulus IEA cellular response to glucose starvation IDA unfolded protein response, activation of signaling protein activity TAS asparagine biosynthetic process IC response to amino acid stimulus IEA response to follicle-stimulating hormone stimulus IEA glutamine metabolic process IEA cofactor binding IEA asparagine synthase (glutamine-hydrolyzing) activity IEA ATP binding IEA Asparagine synthetase [glutamine-hydrolyzing]; 6.3.5.4; Cell cycle control protein TS11; Glutamine-dependent asparagine synthetase 12690205 12853948 14702039 15489334 19608861 21269460 2564390 2565875 2569668 2573597 2886907 3470743 NA ASNS 1 Asparagine synthetase [glutamine-hydrolyzing] 6.3.5.4 Cell cycle control protein TS11 Glutamine-dependent asparagine synthetase gene 2969 0.130182721566302 FOXO3 D - Genome Maintenance transcription factor complex IBA membrane IEA cytosol IBA insulin receptor signaling pathway IBA pattern specification process IBA nerve growth factor receptor signaling pathway TAS DNA damage response, signal transduction by p53 class mediator IEA phosphoinositide-mediated signaling TAS initiation of primordial ovarian follicle growth IBA apoptosis IDA ovulation (sensu Mammalia) IBA glucose homeostasis IBA embryonic development IBA negative regulation of transcription from RNA polymerase II promoter IMP oocyte maturation IBA induction of apoptosis IBA response to DNA damage stimulus IBA regulation of translation IDA antral ovarian follicle growth IBA regulation of transcription factor activity IBA epidermal growth factor receptor signaling pathway TAS fibroblast growth factor receptor signaling pathway TAS positive regulation of erythrocyte differentiation IDA regulation of cell proliferation IBA positive regulation of transcription from RNA polymerase II promoter IDA tissue development IBA sequence-specific DNA binding IDA double-stranded DNA binding IBA DNA bending activity IBA RNA polymerase II transcription factor activity, enhancer binding IBA transcription factor binding IBA Forkhead box protein O3; AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1 10102273 11154281 14574404 15489334 16751106 17711846 17940099 18220336 18593906 18669648 19690332 20068231 21269460 21329882 22761832 22820736 9345057 9479491 NA FOXO3 -1 Forkhead box protein O3 AF6q21 protein Forkhead in rhabdomyosarcoma-like 1 TF 1401 0.123378846497975 FOXO1 D - Genome Maintenance transcription factor complex IBA mitochondrial part ISS cytosol ISS insulin receptor signaling pathway ISS pattern specification process IBA negative regulation of apoptosis IDA nerve growth factor receptor signaling pathway TAS thermoregulation ISS blood vessel development IBA cell glucose homeostasis ISS negative regulation of fat cell differentiation ISS phosphoinositide-mediated signaling TAS positive regulation of gluconeogenesis IEA apoptosis IEA embryonic development IBA response to DNA damage stimulus ISS regulation of transcription factor activity IBA epidermal growth factor receptor signaling pathway TAS fibroblast growth factor receptor signaling pathway TAS endocrine pancreas development TAS positive regulation of transcription from RNA polymerase II promoter IDA regulation of cell proliferation IBA tissue development IBA fat cell differentiation ISS negative regulation of transcription, DNA-dependent ISS protein amino acid acetylation ISS cellular response to starvation ISS sequence-specific DNA binding IDA double-stranded DNA binding IBA protein kinase binding IBA DNA bending activity IBA chromatin binding ISS RNA polymerase II transcription factor activity, enhancer binding IBA protein phosphatase 2A binding ISS transcription factor binding IBA Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma 10358075 10358076 11237865 11311120 11980723 12228231 15057823 15220471 15489334 15668399 15890677 18356527 18669648 18786403 18951090 19221179 20068231 20668652 21245099 21406692 8187070 8275086 9479491 NA FOXO1 -1 Forkhead box protein O1 Forkhead box protein O1A Forkhead in rhabdomyosarcoma gene 1291 0.169823635651924 HN1 N - Not Matched nucleus IEA Hematological and neurological expressed 1 protein; Androgen-regulated protein 2 14702039 15094197 15489334 16602700 17081983 17924679 18088087 18669648 19608861 19690332 20068231 21269460 21406692 NA HN1 1 Hematological and neurological expressed 1 protein Androgen-regulated protein 2 gene 1291 0.0178778291877126 SAMD4A P - Translation cytoplasm IEA cell junction IEA synapse IEA dendrite IEA positive regulation of protein biosynthetic process IDA translation repressor activity IDA Protein Smaug homolog 1; Smaug 1; hSmaug1; Sterile alpha motif domain-containing protein 4A; SAM domain-containing protein 4A 10470851 12508121 14702039 15489334 16221671 18669648 NA SMAG1 -1 Protein Smaug homolog 1 Smaug 1 hSmaug1 Sterile alpha motif domain-containing protein 4A SAM domain-containing protein 4A gene 1291 0.00401808768260578 DNAJA3 D - Genome Maintenance mitochondrial nucleoid IDA cell junction IEA neuromuscular junction ISS mitochondrial matrix IDA postsynaptic membrane ISS nucleus IDA extrinsic to plasma membrane ISS cytosol IEA negative regulation of apoptosis IDA positive regulation of apoptosis IDA negative regulation of cell proliferation IDA response to heat IEA caspase activation IDA small GTPase mediated signal transduction IEA cell aging IEA protein stabilization IDA inhibition of NF-kappaB transcription factor IDA negative regulation of transcription from RNA polymerase II promoter IDA embryonic development IEA activated T cell apoptosis IEA neuromuscular junction development IDA protein folding IDA positive regulation of T cell proliferation IEA positive regulation of protein ubiquitination IDA negative regulation of protein kinase activity IDA mitochondrial DNA replication IEA negative regulation of caspase activity IDA negative regulation of I-kappaB kinase/NF-kappaB cascade IDA small GTPase regulator activity IEA interferon-gamma receptor binding IDA ATP binding IEA metal ion binding IEA DnaJ homolog subfamily A member 3, mitochondrial; DnaJ protein Tid-1; hTid-1; Hepatocellular carcinoma-associated antigen 57; Tumorous imaginal discs protein Tid56 homolog; Precursor 10411904 11679576 12097419 14702039 15489334 15616553 21269460 9683573 NA DNJA3 1 DnaJ homolog subfamily A member 3, mitochondrial DnaJ protein Tid-1 hTid-1 Hepatocellular carcinoma-associated antigen 57 Tumorous imaginal discs protein Tid56 homolog Precursor gene 1291 0.0248901662006841 UBFD1 Ubiquitin domain-containing protein UBFD1; Ubiquitin-binding protein homolog 10493829 14702039 15616553 19285159 19690332 21269460 NA UBFD1 1 Ubiquitin domain-containing protein UBFD1 Ubiquitin-binding protein homolog gene 1291 0.167028605541731 A - Transport and Sensing coated pit IDA Golgi apparatus IDA late endosome IDA integral to plasma membrane TAS integral to membrane IEA lysosome IDA clathrin-coated endocytic vesicle membrane TAS early endosome IDA external side of plasma membrane IDA endosome membrane TAS lipid metabolic process TAS cholesterol absorption IMP cholesterol homeostasis IMP phospholipid transport ISS virus-host interaction IEA lipoprotein metabolic process TAS lipoprotein catabolic process IEA cholesterol metabolic process IEA low-density lipoprotein receptor activity IDA very-low-density lipoprotein receptor activity IDA calcium ion binding IEA low-density lipoprotein binding IEA Low-density lipoprotein receptor; LDL receptor; Precursor 10090484 10206683 10391209 10422803 10447263 10660340 10882754 10933493 10978268 10980548 11100124 11298688 12221107 12459547 12615904 12754519 12944399 1301956 1446662 1464748 14702039 14739284 15057824 15489334 15592455 16335952 17142622 17461796 1867200 19159218 19319977 19520913 21149300 21269460 21418584 22160468 2318961 2569482 2726768 2988123 3005267 3104336 3263645 3955657 6091915 7550239 7573037 7578052 7583548 7603991 7635461 7635482 7649546 7649549 8127891 8168830 8347689 8462973 8664907 8740918 9016531 9026534 9104431 9143924 9254862 9259195 9262405 9452094 9452095 9452118 9654205 9678702 9852677 NA LDLR -1 Low-density lipoprotein receptor LDL receptor Precursor gene 1291 0.0107333449193607 MVB12B A - Transport and Sensing late endosome membrane IEA protein transport IEA Multivesicular body subunit 12B; ESCRT-I complex subunit MVB12B; Protein FAM125B 14702039 15489334 18005716 NA MB12B -1 Multivesicular body subunit 12B ESCRT-I complex subunit MVB12B Protein FAM125B gene 1973 1.4089862236171E-5 CTDSPL C - Cellular Fate and Organization nucleus IEA dephosphorylation IEA phosphoprotein phosphatase activity IEA metal ion binding IEA CTD small phosphatase-like protein; CTDSP-like; 3.1.3.16; Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3; NIF-like protein; Nuclear LIM interactor-interacting factor 1; NLI-interacting factor 1; Protein YA22; hYA22; RBSP3; Small C-terminal domain phosphatase 3; SCP3; Small CTD phosphatase 3 12721286 15051889 15681389 16533400 18058037 9179494 NA CTDSL -1 CTD small phosphatase-like protein CTDSP-like 3.1.3.16 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3 NIF-like protein Nuclear LIM interactor-interacting factor 1 NLI-interacting factor 1 Protein YA22 hYA22 RBSP3 Small C-terminal domain phosphatase 3 SCP3 Small CTD phosphatase 3 gene 1291 0.104397055026454 SLC33A1 A - Transport and Sensing Golgi membrane TAS integral to plasma membrane TAS endoplasmic reticulum membrane TAS cell death IEA acetyl-CoA transporter activity TAS Acetyl-coenzyme A transporter 1; AT-1; Acetyl-CoA transporter 1; Solute carrier family 33 member 1 14702039 15489334 16959974 19061983 22243965 9096318 NA ACATN 1 Acetyl-coenzyme A transporter 1 AT-1 Acetyl-CoA transporter 1 Solute carrier family 33 member 1 gene 1291 0.0262453699169434 HLX C - Cellular Fate and Organization nucleus IEA liver development IEA positive regulation of cell proliferation IEA positive regulation of organ size IEA embryonic digestive tract morphogenesis IEA striated muscle development IEA negative regulation of T-helper 2 cell differentiation IEA positive regulation of T-helper 1 cell differentiation IEA multicellular organismal development TAS transcription, DNA-dependent IEA cell differentiation IEA enteric nervous system development IEA sequence-specific DNA binding IDA transcription factor activity IEA H2.0-like homeobox protein; Homeobox protein HB24; Homeobox protein HLX1 14702039 15489334 16710414 1676597 7806220 8095486 NA HLX -1 H2.0-like homeobox protein Homeobox protein HB24 Homeobox protein HLX1 gene 1291 0.229882269744199 MATN2 N - Not Matched extracellular matrix (sensu Metazoa) NAS basement membrane IEA dendrite regeneration IEA glial cell migration IEA axon guidance IEA neuron migration IEA response to axon injury IEA calcium ion binding IEA Matrilin-2; Precursor 11124542 12975309 14702039 15489334 16421571 17974005 9083061 NA MATN2 -1 Matrilin-2 Precursor gene 1291 0.0145073523432895 FOXN3 D - Genome Maintenance transcription factor complex IBA G2 phase of mitotic cell cycle TAS pattern specification process IBA regulation of transcription factor activity IBA tissue development IBA DNA damage checkpoint TAS embryonic development IBA negative regulation of transcription, DNA-dependent IDA sequence-specific DNA binding IEA double-stranded DNA binding IBA DNA bending activity IBA RNA polymerase II transcription factor activity, enhancer binding IBA transcription factor binding IBA Forkhead box protein N3; Checkpoint suppressor 1 12508121 15489334 16102918 19690332 21406692 9154802 NA FOXN3 -1 Forkhead box protein N3 Checkpoint suppressor 1 gene 1291 2.16798577752803E-4 TRAK2 T - Transcription mitochondrion ISS plasma membrane ISS nucleus IEA early endosome IEA regulation of transcription from RNA polymerase II promoter IEA protein amino acid O-linked glycosylation IEA protein targeting IEA GABA receptor binding NAS Trafficking kinesin-binding protein 2; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein 11161814 14702039 15489334 16630562 9628581 NA TRAK2 -1 Trafficking kinesin-binding protein 2 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein gene 1291 0.011077302875147 SIDT2 A - Transport and Sensing integral to membrane IEA lysosomal membrane IDA RNA interference IEA RNA transporter activity IEA SID1 transmembrane family member 2; Precursor 10810093 12975309 14702039 15340161 16303743 17081983 17897319 18669648 NA SIDT2 -1 SID1 transmembrane family member 2 Precursor gene 1291 0.145385885608534 CERS6 T - Transcription nuclear membrane IEA endoplasmic reticulum membrane TAS integral to membrane IEA sphingolipid biosynthetic process TAS phospholipid metabolic process TAS ceramide biosynthetic process IEA sequence-specific DNA binding IEA transcription factor activity IEA sphingosine N-acyltransferase activity IEA Ceramide synthase 6; CerS5; LAG1 longevity assurance homolog 6 14702039 15489334 15815621 19159218 NA CERS6 1 Ceramide synthase 6 CerS5 LAG1 longevity assurance homolog 6 gene 1291 0.401766357395265 PEAK1 C - Cellular Fate and Organization cytoplasm IEA actin cytoskeleton IDA focal adhesion IDA protein amino acid autophosphorylation IDA cell migration IDA non-membrane spanning protein tyrosine kinase activity IDA ATP binding IEA Pseudopodium-enriched atypical kinase 1; 2.7.10.2; Sugen kinase 269; Tyrosine-protein kinase SgK269 12056414 12471243 14702039 16572171 17344846 20534451 NA PEAK1 -1 Pseudopodium-enriched atypical kinase 1 2.7.10.2 Sugen kinase 269 Tyrosine-protein kinase SgK269 gene 1894 1.0 NFIC D - Genome Maintenance nucleus IEA DNA replication IEA transcription from RNA polymerase II promoter TAS positive regulation of transcription from RNA polymerase II promoter IDA negative regulation of transcription from RNA polymerase II promoter IDA transcription factor activity IDA DNA binding IEA Nuclear factor 1 C-type; NF1-C; Nuclear factor 1/C; CCAAT-box-binding transcription factor; CTF; Nuclear factor I/C; NF-I/C; NFI-C; TGGCA-binding protein 14702039 15057824 15489334 17081983 18220336 18669648 18691976 19690332 20068231 3398920 8710515 NA NFIC 0 Nuclear factor 1 C-type NF1-C Nuclear factor 1/C CCAAT-box-binding transcription factor CTF Nuclear factor I/C NF-I/C NFI-C TGGCA-binding protein TF 1291 0.0126543239549583 ATP6V1C1 C - Cellular Fate and Organization plasma membrane ISS proton-transporting two-sector ATPase complex TAS apical part of cell IEA cytoplasmic vesicle IEA cytosol TAS iron ion homeostasis TAS insulin receptor signaling pathway TAS interaction with host TAS ATP hydrolysis coupled proton transport IEA hydrogen-exporting ATPase activity, phosphorylative mechanism IEA hydrogen ion transporting ATPase activity, rotational mechanism TAS V-type proton ATPase subunit C 1; V-ATPase subunit C 1; Vacuolar proton pump subunit C 1 11707601 12384298 15489334 21269460 2147024 8250920 NA VATC1 1 V-type proton ATPase subunit C 1 V-ATPase subunit C 1 Vacuolar proton pump subunit C 1 gene 1291 2.84038421336394E-4 T - Transcription nucleus TAS transcription from RNA polymerase II promoter TAS multicellular organismal development TAS rhythmic process IEA sequence-specific DNA binding IEA double-stranded DNA binding TAS transcription factor activity IEA Hepatic leukemia factor 1386162 1516826 15489334 NA HLF -1 Hepatic leukemia factor gene 1291 0.0714360801321983 ARHGEF6 C - Cellular Fate and Organization lamellipodium ISS cytosol TAS regulation of small GTPase mediated signal transduction TAS nerve growth factor receptor signaling pathway TAS small GTPase mediated signal transduction TAS regulation of Rho protein signal transduction IEA lamellipodium biogenesis ISS JNK cascade NAS apoptosis NAS phospholipid binding IEA Rho guanyl-nucleotide exchange factor activity NAS GTPase activator activity NAS Rho guanine nucleotide exchange factor 6; Alpha-Pix; COOL-2; PAK-interacting exchange factor alpha; Rac/Cdc42 guanine nucleotide exchange factor 6 11017088 11337747 14702039 15005707 15144186 15489334 15772651 17974005 19690332 23285027 7584026 NA ARHG6 -1 Rho guanine nucleotide exchange factor 6 Alpha-Pix COOL-2 PAK-interacting exchange factor alpha Rac/Cdc42 guanine nucleotide exchange factor 6 gene 1291 0.0781675657111357 KCNAB1 A - Transport and Sensing cytoplasm IEA plasma membrane TAS integral to membrane IEA synaptic transmission TAS potassium ion transport TAS voltage-gated potassium channel activity IEA potassium channel regulator activity TAS Voltage-gated potassium channel subunit beta-1; K(+) channel subunit beta-1; Kv-beta-1 14702039 15489334 7499366 7603988 7649300 7890032 7890764 8938711 NA KCAB1 -1 Voltage-gated potassium channel subunit beta-1 K(+) channel subunit beta-1 Kv-beta-1 gene 1582 0.00102007200152899 LGR4 C - Cellular Fate and Organization plasma membrane IEA integral to membrane IEA male genitalia development IEA positive regulation of transcription, DNA-dependent IEA negative regulation of transcription, DNA-dependent IEA epithelial cell proliferation IEA G-protein coupled receptor activity TAS protein-hormone receptor activity IEA Leucine-rich repeat-containing G-protein coupled receptor 4; G-protein coupled receptor 48; Precursor 11401528 16554811 NA LGR4 1 Leucine-rich repeat-containing G-protein coupled receptor 4 G-protein coupled receptor 48 Precursor gene 1291 4.71216325971068E-4 C - Cellular Fate and Organization cytosol TAS regulation of small GTPase mediated signal transduction TAS nerve growth factor receptor signaling pathway TAS regulation of Rho protein signal transduction IEA apoptosis TAS Rho protein signal transduction TAS phospholipid binding IEA Rho guanyl-nucleotide exchange factor activity TAS Rho guanine nucleotide exchange factor 3; Exchange factor found in platelets and leukemic and neuronal tissues; XPLN 10873612 11230166 12221096 14702039 15489334 NA ARHG3 -1 Rho guanine nucleotide exchange factor 3 Exchange factor found in platelets and leukemic and neuronal tissues XPLN gene 1291 0.00323169906125048 PDZD11 N - Not Matched basolateral plasma membrane IDA extracellular region IEA cytosol IDA PDZ domain-containing protein 11 11042152 12975309 15489334 15772651 17974005 21269460 NA PDZ11 1 PDZ domain-containing protein 11 gene 1550 0.00210737770799206 ZCCHC24 N - Not Matched zinc ion binding IEA nucleic acid binding IEA Zinc finger CCHC domain-containing protein 24 14702039 15164054 15489334 17081983 18669648 19690332 NA ZCH24 -1 Zinc finger CCHC domain-containing protein 24 gene 1291 9.22127029133089E-4 CHPF N - Not Matched Golgi membrane TAS integral to membrane IEA chondroitin sulfate biosynthetic process TAS carbohydrate metabolic process TAS glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IEA N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity IEA metal ion binding IEA Chondroitin sulfate synthase 2; 2.4.1.175; 2.4.1.226; Chondroitin glucuronyltransferase 2; Chondroitin-polymerizing factor; ChPF; Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase II; N-acetylgalactosaminyltransferase 2 11230166 12716890 12761225 12975309 14702039 15489334 15815621 NA CHSS2 1 Chondroitin sulfate synthase 2 2.4.1.175 2.4.1.226 Chondroitin glucuronyltransferase 2 Chondroitin-polymerizing factor ChPF Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase II N-acetylgalactosaminyltransferase 2 gene 1291 0.0178778291877126 MRC1 A - Transport and Sensing integral to plasma membrane TAS endosome membrane IDA receptor-mediated endocytosis IDA receptor activity IDA mannose binding TAS Macrophage mannose receptor 1; MMR; C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; Macrophage mannose receptor 1-like protein 1; CD206; Precursor 10779515 1294118 15164054 15489334 1730714 18780401 20035344 2258707 2373685 NA MRC1 -1 Macrophage mannose receptor 1 MMR C-type lectin domain family 13 member D C-type lectin domain family 13 member D-like Macrophage mannose receptor 1-like protein 1 CD206 Precursor gene 1507 5.02057586636155E-4 RMI2 D - Genome Maintenance cytoplasm IDA nucleus IDA DNA replication IEA DNA binding IEA RecQ-mediated genome instability protein 2; hRMI2; BLM-associated protein of 18 kDa; BLAP18 14702039 15489334 15616553 18923082 18923083 20068231 NA RMI2 1 RecQ-mediated genome instability protein 2 hRMI2 BLM-associated protein of 18 kDa BLAP18 gene 1291 0.0849340188103281 UHRF1 D - Genome Maintenance heterochromatin IDA nuclear chromatin IDA euchromatin IDA replication fork IDA nuclear matrix ISS positive regulation of cellular protein metabolic process IDA cell cycle IEA maintenance of DNA methylation IMP DNA repair IEA protein ubiquitination during ubiquitin-dependent protein catabolic process IDA cell proliferation IEP positive regulation of transcription from RNA polymerase II promoter IC negative regulation of transcription from RNA polymerase II promoter IDA transcription, DNA-dependent IEA protein autoubiquitination IDA ubiquitin-protein ligase activity IDA methyl-CpG binding IDA transcription factor activity TAS zinc ion binding IDA nucleosomal histone binding ISS methylated histone residue binding IDA identical protein binding ISS E3 ubiquitin-protein ligase UHRF1; 6.3.2.-; Inverted CCAAT box-binding protein of 90 kDa; Nuclear protein 95; Nuclear zinc finger protein Np95; HuNp95; hNp95; RING finger protein 106; Transcription factor ICBP90; Ubiquitin-like PHD and RING finger domain-containing protein 1; hUHRF1; Ubiquitin-like-containing PHD and RING finger domains protein 1 10646863 12838312 14702039 15009091 15057824 15178447 15361834 15489334 16964243 17067204 17081983 17370265 17673620 17967883 17974005 18220336 18669648 18772889 18931436 18945682 19056828 19491893 19608861 19690332 20026581 20068231 21269460 21406692 21489993 21731699 21745816 21777816 21808299 21808300 22096602 22100450 22286757 22330138 22411829 22837395 22945642 NA UHRF1 1 E3 ubiquitin-protein ligase UHRF1 6.3.2.- Inverted CCAAT box-binding protein of 90 kDa Nuclear protein 95 Nuclear zinc finger protein Np95 HuNp95 hNp95 RING finger protein 106 Transcription factor ICBP90 Ubiquitin-like PHD and RING finger domain-containing protein 1 hUHRF1 Ubiquitin-like-containing PHD and RING finger domains protein 1 gene 1567 0.0261796027264088 S100A2 N - Not Matched endothelial cell migration IMP calcium ion binding NAS Protein S100-A2; CAN19; Protein S-100L; S100 calcium-binding protein A2 1286667 1372446 15489334 16710414 18394645 20188096 21269460 9481475 NA S10A2 1 Protein S100-A2 CAN19 Protein S-100L S100 calcium-binding protein A2 gene 1291 0.00348473781211124 C - Cellular Fate and Organization apical plasma membrane IDA endoplasmic reticulum IDA integral to plasma membrane TAS lipid raft NAS anchored to external side of plasma membrane IEA external side of plasma membrane ISS dendrite IEA cytosol IEA growth cone ISS T cell receptor signaling pathway ISS cell-cell adhesion ISS negative regulation of cell migration ISS retinal cone cell development ISS focal adhesion formation ISS positive regulation of T cell activation ISS cytoskeleton organization and biogenesis ISS negative regulation of axonogenesis ISS negative regulation of protein kinase activity ISS angiogenesis ISS positive regulation of release of sequestered calcium ion into cytosol ISS negative regulation of T cell receptor signaling pathway ISS Rho GTPase activator activity ISS Thy-1 membrane glycoprotein; CDw90; Thy-1 antigen; CD90; Precursor 10944468 15489334 17974005 19159218 19349973 2864690 7683034 NA THY1 1 Thy-1 membrane glycoprotein CDw90 Thy-1 antigen CD90 Precursor gene 1291 0.262932179481671 SEMA6A D - Genome Maintenance axon NAS integral to plasma membrane IEA integral to membrane NAS centrosome localization IEA axon guidance NAS cytoskeleton organization and biogenesis NAS apoptosis NAS organ morphogenesis NAS neuron migration IEA cell surface receptor linked signal transduction NAS transmembrane receptor activity IEA Semaphorin-6A; Semaphorin VIA; Sema VIA; Semaphorin-6A-1; SEMA6A-1; Precursor 10718198 10993894 15372022 21406692 NA SEM6A -1 Semaphorin-6A Semaphorin VIA Sema VIA Semaphorin-6A-1 SEMA6A-1 Precursor gene 1291 0.0849340188103281 BZW2 C - Cellular Fate and Organization RNA metabolic process IEA cell differentiation IEA nervous system development IEA Basic leucine zipper and W2 domain-containing protein 2 11042152 12690205 14702039 15489334 17081983 18669648 18691976 19608861 19690332 20068231 21269460 21406692 NA BZW2 1 Basic leucine zipper and W2 domain-containing protein 2 gene 1291 0.193676256758731 BZW1 T - Transcription cytoplasm IDA regulation of transcription, DNA-dependent IEA transcription, DNA-dependent IEA Basic leucine zipper and W2 domain-containing protein 1; Protein Orf 11524015 14702039 15489334 15815621 16964243 17081983 18318008 18669648 19690332 20068231 21269460 21406692 7584026 NA BZW1 1 Basic leucine zipper and W2 domain-containing protein 1 Protein Orf gene 1358 1.0 T - Transcription nucleoplasm ISS ureteric bud branching IEP inner ear morphogenesis ISS positive regulation of transcription from RNA polymerase II promoter IDA mesonephros development ISS thyroid gland development IMP positive regulation of transcription, DNA-dependent IDA central nervous system development IEP transcription, DNA-dependent IDA transcription factor activity IDA thyroid-stimulating hormone receptor activity TAS Paired box protein Pax-8 11232006 11502839 1337742 14702039 15489334 15815621 19010321 7737192 8413205 9590296 NA PAX8 0 Paired box protein Pax-8 TF 1291 0.142676365585747 C - Cellular Fate and Organization extracellular matrix (sensu Metazoa) IDA extracellular space IDA regulation of proteolysis IDA protein folding TAS transforming growth factor beta receptor signaling pathway IEA multicellular organismal development TAS growth hormone secretion TAS regulation of cell differentiation TAS regulation of transforming growth factor beta receptor signaling pathway TAS regulation of cell growth TAS transforming growth factor beta binding IDA integrin binding NAS calcium ion binding NAS transforming growth factor beta receptor activity NAS glycosaminoglycan binding NAS Latent-transforming growth factor beta-binding protein 4; LTBP-4; Precursor 14702039 15057824 16157329 19836010 9271198 9660815 NA LTBP4 -1 Latent-transforming growth factor beta-binding protein 4 LTBP-4 Precursor gene 1299 1.0 C - Cellular Fate and Organization protein complex ISS nucleus IDA lysosome IEA positive regulation of epithelial cell proliferation IDA ureteric bud branching IEP transcription from RNA polymerase II promoter TAS cell fate determination ISS mesonephros development ISS aging IEA neural tube closure ISS axonogenesis TAS negative regulation of transcription from RNA polymerase II promoter IEA vestibulocochlear nerve formation ISS brain morphogenesis ISS stem cell differentiation ISS mesodermal cell fate specification ISS pancreas development IEA positive regulation of transcription from RNA polymerase II promoter IDA negative regulation of cytolysis IMP protein kinase B signaling cascade ISS optic cup morphogenesis (sensu Mammalia) ISS response to nutrient levels IEA glial cell differentiation ISS optic nerve structural organization ISS negative regulation of caspase activity IDA negative regulation of transcription, DNA-dependent IMP visual perception TAS superoxide-generating NADPH oxidase activity ISS Paired box protein Pax-2 11168927 11180607 1378753 15164054 15652857 19690332 19954729 21380624 21575608 22213154 7819127 7981748 8661132 9760197 NA PAX2 0 Paired box protein Pax-2 TF 1291 0.0584361174484631 N - Not Matched methyltransferase activity IEA Methyltransferase-like protein 2B; 2.1.1.- 12853948 14702039 15489334 18669648 19690332 20068231 21269460 NA MET2B 1 Methyltransferase-like protein 2B 2.1.1.- gene 1291 0.0483359921870727 METTL2A N - Not Matched methyltransferase activity IEA Methyltransferase-like protein 2A; 2.1.1.- 11042152 14702039 15489334 16625196 NA MET2A 1 Methyltransferase-like protein 2A 2.1.1.- gene 1291 0.300262688080211 C - Cellular Fate and Organization membrane TAS extracellular matrix (sensu Metazoa) TAS basement membrane IEA cellular morphogenesis during differentiation IEA astrocyte development IEA cell adhesion IEA visual perception IEA structural molecule activity TAS Laminin subunit gamma-3; Laminin-12 subunit gamma; Laminin-14 subunit gamma; Laminin-15 subunit gamma; Precursor 10225960 15164053 21572413 NA LAMC3 -1 Laminin subunit gamma-3 Laminin-12 subunit gamma Laminin-14 subunit gamma Laminin-15 subunit gamma Precursor gene 1291 0.00323169906125048 LAD1 N - Not Matched actin cytoskeleton IDA basement membrane IEA structural molecule activity TAS Ladinin-1; Lad-1; Linear IgA disease antigen; LADA 14702039 15489334 21269460 21406692 NA LAD1 1 Ladinin-1 Lad-1 Linear IgA disease antigen LADA gene 1291 0.0684467560661034 TBL2 Transducin beta-like protein 2; WS beta-transducin repeats protein; WS-betaTRP; Williams-Beuren syndrome chromosomal region 13 protein 10575226 11230166 12975309 17525332 21269460 9860302 NA TBL2 1 Transducin beta-like protein 2 WS beta-transducin repeats protein WS-betaTRP Williams-Beuren syndrome chromosomal region 13 protein gene 1291 0.00944017613702838 D - Genome Maintenance septin complex IEA cell cycle IEA cell division IEA GTP binding IEA Septin-10 12711328 14702039 15489334 15815621 15915442 21269460 NA SEP10 -1 Septin-10 gene 1291 0.0947091236009375 MTFR1 E - Energy Production mitochondrion ISS plasma membrane IDA aerobic respiration ISS mitochondrial fission ISS Mitochondrial fission regulator 1; Chondrocyte protein with a poly-proline region; Precursor 15489334 18669648 20068231 7584026 NA MTFR1 1 Mitochondrial fission regulator 1 Chondrocyte protein with a poly-proline region Precursor gene 1291 0.0222487677836032 SLC11A1 C - Cellular Fate and Organization integral to plasma membrane NAS late endosome membrane TAS outer membrane (sensu ProteoBacteria) IEA phagocytic vesicle membrane IDA lysosome ISS respiratory burst ISS phagocytosis ISS L-arginine import ISS antigen processing and presentation of peptide antigen ISS negative regulation of cytokine production ISS activation of protein kinase activity ISS iron ion homeostasis IMP positive regulation of phagocytosis ISS T cell proliferation during immune response ISS inflammatory response ISS vacuolar acidification ISS positive regulation of transcription from RNA polymerase II promoter ISS positive regulation of T-helper 1 type immune response ISS response to lipopolysaccharide ISS interleukin-2 production ISS mRNA stabilization ISS protein import into nucleus, translocation IEA positive regulation of interferon-gamma production ISS T cell cytokine production ISS interaction with host TAS defense response to protozoan ISS cadmium ion homeostasis IGI positive regulation of dendritic cell antigen processing and presentation ISS MHC class II biosynthetic process ISS defense response to Gram-negative bacterium ISS nitrite transport ISS macrophage activation ISS wound healing ISS iron ion transport IMP interleukin-3 production ISS metal ion:hydrogen antiporter activity IGI manganese ion transporter activity ISS protein homodimerization activity IDA Natural resistance-associated macrophage protein 1; NRAMP 1 10967134 16103355 16395392 7717395 7964458 7980580 8529098 8537108 NA NRAM1 -1 Natural resistance-associated macrophage protein 1 NRAMP 1 gene 1291 7.10291946619602E-4 OTUD1 OTU domain-containing protein 1; DUBA-7 15164054 NA OTUD1 -1 OTU domain-containing protein 1 DUBA-7 gene 1447 0.0599310847282657 SEMA5A C - Cellular Fate and Organization plasma membrane TAS integral to membrane IEA patterning of blood vessels IEA axon guidance TAS cell-cell signaling TAS cell adhesion TAS axon guidance receptor activity IEA Semaphorin-5A; Semaphorin-F; Sema F; Precursor 15218527 15372022 15489334 19850054 20696765 21706053 9464278 NA SEM5A -1 Semaphorin-5A Semaphorin-F Sema F Precursor gene 1291 0.0449492875329337 MCCC2 M - Other Metabolism mitochondrial matrix IEA mitochondrial inner membrane TAS coenzyme A metabolic process IEA leucine catabolic process TAS methylcrotonoyl-CoA carboxylase activity NAS ATP binding IEA Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial; MCCase subunit beta; 6.4.1.4; 3-methylcrotonyl-CoA carboxylase 2; 3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta; Precursor 11170888 11181649 11406611 15372022 15489334 16023992 21269460 22150417 NA MCCB 1 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCase subunit beta 6.4.1.4 3-methylcrotonyl-CoA carboxylase 2 3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit 3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta Precursor gene 1291 0.00728811177281109 DNAJC27 C - Cellular Fate and Organization mitochondrion IEA protein folding IEA small GTPase mediated signal transduction IEA GTP binding IEA DnaJ homolog subfamily C member 27; Rab and DnaJ domain-containing protein 14980719 15489334 17974005 NA DJC27 -1 DnaJ homolog subfamily C member 27 Rab and DnaJ domain-containing protein gene 1291 0.169823635651924 C - Cellular Fate and Organization cytoplasm IDA endoplasmic reticulum IEA nucleus IDA nuclear matrix IEA mRNA processing IEA RNA splicing TAS regulation of nuclear mRNA splicing, via spliceosome TAS chromosome segregation IDA virus-host interaction IEA innate immune response IC sperm chromatin condensation TAS protein kinase cascade IDA positive regulation of viral genome replication IDA negative regulation of viral genome replication IDA magnesium ion binding IDA protein serine/threonine kinase activity IDA ATP binding IDA SRSF protein kinase 1; 2.7.11.1; SFRS protein kinase 1; Serine/arginine-rich protein-specific kinase 1; SR-protein-specific kinase 1 10049757 10390541 11509566 12134018 12565829 14555757 14574404 15034300 15489334 16122776 16209947 17081983 17223538 18155240 18342604 18669648 18687337 18691976 19240134 19477182 19553338 19674106 19690332 19886675 20708644 21157427 21205200 21205204 21269460 21406692 8208298 9237760 NA SRPK1 1 SRSF protein kinase 1 2.7.11.1 SFRS protein kinase 1 Serine/arginine-rich protein-specific kinase 1 SR-protein-specific kinase 1 gene 1291 2.15150330025378E-4 SNF8 T - Transcription transcription factor complex IDA late endosome membrane IEA cytosol TAS regulation of transcription from RNA polymerase II promoter IDA endosome transport TAS protein transport IEA transcription, DNA-dependent IEA membrane organization and biogenesis TAS transcription factor binding IDA Vacuolar-sorting protein SNF8; ELL-associated protein of 30 kDa; ESCRT-II complex subunit VPS22; hVps22 10419521 14505570 14519844 15489334 16260042 16857164 16973552 17010938 17714434 17959629 18031739 18539118 21269460 NA SNF8 1 Vacuolar-sorting protein SNF8 ELL-associated protein of 30 kDa ESCRT-II complex subunit VPS22 hVps22 gene 1291 0.00955317868538724 FOXK2 D - Genome Maintenance transcription factor complex IBA pattern specification process IBA regulation of transcription factor activity IBA tissue development IBA embryonic development IBA sequence-specific DNA binding IDA magnesium ion binding IDA double-stranded DNA binding IBA DNA bending activity IBA RNA polymerase II transcription factor activity, enhancer binding IBA transcription factor binding IBA Forkhead box protein K2; Cellular transcription factor ILF-1; FOXK1; Interleukin enhancer-binding factor 1 12402362 1339390 16624804 16625196 17525332 18220336 18669648 1909027 19690332 20068231 21406692 NA FOXK2 1 Forkhead box protein K2 Cellular transcription factor ILF-1 FOXK1 Interleukin enhancer-binding factor 1 gene 1291 2.35764706008124E-4 M - Other Metabolism unconventional myosin complex NAS filamentous actin IEA cortical actin cytoskeleton IEA negative regulation of cell adhesion IEA positive regulation of cell migration IEA defense response to Gram-positive bacterium IEA neutrophil degranulation IEA regulation of innate immune response IEA calmodulin binding NAS motor activity IEA actin binding NAS ATP binding NAS Unconventional myosin-If; Myosin-Ie 11804589 14702039 15057824 15489334 19367720 9119401 NA MYO1F -1 Unconventional myosin-If Myosin-Ie gene 1291 0.0496105166462564 TSC22D1 C - Cellular Fate and Organization cytoplasm IEA nucleus IEA positive regulation of cell proliferation IEA negative regulation of apoptosis IEA positive regulation of apoptosis IEA transcription from RNA polymerase II promoter TAS transcription factor activity IEA TSC22 domain family protein 1; Cerebral protein 2; Regulatory protein TSC-22; TGFB-stimulated clone 22 homolog; Transforming growth factor beta-1-induced transcript 4 protein 10488076 12056414 14702039 15057823 15489334 17974005 19690332 21269460 8651929 9022669 9026990 NA T22D1 -1 TSC22 domain family protein 1 Cerebral protein 2 Regulatory protein TSC-22 TGFB-stimulated clone 22 homolog Transforming growth factor beta-1-induced transcript 4 protein gene 1291 0.0617358293036639 KIAA1324L N - Not Matched integral to membrane IEA UPF0577 protein KIAA1324-like; Estrogen-induced gene 121-like protein; hEIG121L; Precursor 12690205 12853948 14702039 15489334 17475571 NA K132L -1 UPF0577 protein KIAA1324-like Estrogen-induced gene 121-like protein hEIG121L Precursor gene 1291 0.0617358293036639 M - Other Metabolism brush border ISS cytoplasm ISS plasma membrane ISS myosin complex IEA filopodium ISS actin filament-based movement ISS actin filament bundle formation ISS microfilament motor activity ISS phosphatidylinositol-3,4,5-triphosphate binding ISS phosphatidylinositol-4,5-bisphosphate binding ISS ATP binding ISS Unconventional myosin-Ib; MYH-1c; Myosin I alpha; MMI-alpha; MMIa 15489334 16959974 21269460 NA MYO1B -1 Unconventional myosin-Ib MYH-1c Myosin I alpha MMI-alpha MMIa gene 1291 0.236305868183754 SASH1 SAM and SH3 domain-containing protein 1; Proline-glutamate repeat-containing protein 12771949 14574404 14702039 15489334 17081983 18669648 21406692 9872452 NA SASH1 -1 SAM and SH3 domain-containing protein 1 Proline-glutamate repeat-containing protein gene 1291 0.0902558525606445 LAMB2 C - Cellular Fate and Organization synapse IEA laminin-3 complex IPI laminin-11 complex TAS axon guidance IEA neuromuscular junction development IEA astrocyte development IEA Schwann cell development IEA cell adhesion IEA axon extension involved in regeneration IEA visual perception IEA structural molecule activity NAS Laminin subunit beta-2; Laminin B1s chain; Laminin-11 subunit beta; Laminin-14 subunit beta; Laminin-15 subunit beta; Laminin-3 subunit beta; Laminin-4 subunit beta; Laminin-7 subunit beta; Laminin-9 subunit beta; S-laminin subunit beta; S-LAM beta; Precursor 15367484 16912710 19159218 21236492 21269460 7698745 7795887 NA LAMB2 -1 Laminin subunit beta-2 Laminin B1s chain Laminin-11 subunit beta Laminin-14 subunit beta Laminin-15 subunit beta Laminin-3 subunit beta Laminin-4 subunit beta Laminin-7 subunit beta Laminin-9 subunit beta S-laminin subunit beta S-LAM beta Precursor gene 1291 0.274618126864437 T - Transcription nucleus IEA transcription from RNA polymerase II promoter TAS sequence-specific DNA binding IEA transcription factor activity IEA CCAAT/enhancer-binding protein delta; C/EBP delta; Nuclear factor NF-IL6-beta; NF-IL6-beta 15489334 16397300 1741402 8314590 NA CEBPD -1 CCAAT/enhancer-binding protein delta C/EBP delta Nuclear factor NF-IL6-beta NF-IL6-beta gene 1291 0.17273753523313 C - Cellular Fate and Organization signal transduction IEA negative regulation of protein import into nucleus IEA negative regulation of transcription from RNA polymerase II promoter IEA cAMP-dependent protein kinase inhibitor activity TAS cAMP-dependent protein kinase inhibitor gamma; PKI-gamma 10880337 11780052 9218452 NA IPKG -1 cAMP-dependent protein kinase inhibitor gamma PKI-gamma gene 1336 0.00429722774369012 CEBPB C - Cellular Fate and Organization nuclear chromatin IEA cytoplasm IEA nucleus IDA nuclear matrix IEA positive regulation of osteoblast differentiation IEA immune response TAS negative regulation of apoptosis IEA brown fat cell differentiation IEA neuron differentiation IEA response to lipopolysaccharide IEA embryonic placenta development IEA regulation of interleukin-6 biosynthetic process IEA induction of apoptosis IEA acute-phase response TAS negative regulation of transcription, DNA-dependent IEA sequence-specific DNA binding IEA RNA polymerase II transcription factor activity, enhancer binding ISS DNA binding TAS CCAAT/enhancer-binding protein beta; C/EBP beta; Liver activator protein; Nuclear factor NF-IL6; Transcription factor 5; TCF-5 11257229 11684016 11780052 11792321 12810706 14702039 15489334 15498874 17467953 20829347 2112087 7635140 NA CEBPB 1 CCAAT/enhancer-binding protein beta C/EBP beta Liver activator protein Nuclear factor NF-IL6 Transcription factor 5 TCF-5 gene 1462 1.0 C - Cellular Fate and Organization Rb-E2F complex IEA nucleus NAS nuclear matrix IEA negative regulation of cell proliferation IEA lung development IEA cytokine and chemokine mediated signaling pathway NAS organ regeneration IEA generation of precursor metabolites and energy TAS positive regulation of transcription from RNA polymerase II promoter IEA positive regulation of transcription from RNA polymerase III promoter IDA macrophage differentiation IEA myeloid cell differentiation NAS cell maturation IEA cholesterol metabolic process IEA inner ear development IEA embryonic placenta development IEA response to glucocorticoid stimulus IEA acute-phase response IEA negative regulation of transcription from RNA polymerase II promoter IEA liver development IEA positive regulation of osteoblast differentiation IEA white fat cell differentiation IEA brown fat cell differentiation IEA virus-host interaction IEA positive regulation of fat cell differentiation IEA urea cycle IEA mitochondrion organization and biogenesis IEA sequence-specific DNA binding IEA RNA polymerase II transcription factor activity, enhancer binding NAS CCAAT/enhancer-binding protein alpha; C/EBP alpha 10725330 15489334 19608861 7575576 9915821 NA CEBPA 0 CCAAT/enhancer-binding protein alpha C/EBP alpha TF 1291 0.00758653205488051 MYO19 M - Other Metabolism cytoplasm IDA mitochondrial outer membrane IEA myosin complex IEA motor activity IEA ATP binding IEA Unconventional myosin-XIX; Myosin head domain-containing protein 1 14702039 15489334 16625196 19932026 NA MYO19 1 Unconventional myosin-XIX Myosin head domain-containing protein 1 gene 1414 0.123513886575145 TM9SF3 N - Not Matched integral to membrane IEA Transmembrane 9 superfamily member 3; EP70-P-iso; SM-11044-binding protein; Precursor 12975309 14702039 15164054 15489334 19159218 19349973 NA TM9S3 1 Transmembrane 9 superfamily member 3 EP70-P-iso SM-11044-binding protein Precursor gene 1291 0.00323169906125048 DNAJC12 F - Protein Fate protein folding IEA DnaJ homolog subfamily C member 12; J domain-containing protein 1 10760603 15164054 15489334 18669648 21269460 NA DJC12 1 DnaJ homolog subfamily C member 12 J domain-containing protein 1 gene 1291 0.199549309027409 LDHA E - Energy Production mitochondrion IEA cytosol TAS cellular carbohydrate metabolic process IEA pyruvate metabolic process TAS cellular response to extracellular stimulus IEA glycolysis NAS L-lactate dehydrogenase activity NAS nucleotide binding IEA L-lactate dehydrogenase A chain; LDH-A; 1.1.1.27; Cell proliferation-inducing gene 19 protein; LDH muscle subunit; LDH-M; Renal carcinoma antigen NY-REN-59 10508479 11276087 1445373 14702039 15489334 15592455 16139798 16554811 1953713 1959923 19608861 19690332 21269460 2334430 3000353 3838278 7908613 NA LDHA 1 L-lactate dehydrogenase A chain LDH-A 1.1.1.27 Cell proliferation-inducing gene 19 protein LDH muscle subunit LDH-M Renal carcinoma antigen NY-REN-59 gene 1291 5.92757397109183E-5 C - Cellular Fate and Organization transport vesicle IEA extracellular region TAS signal transduction NAS regulation of blood vessel size IEA Neurotensin/neuromedin N; Large neuromedin N; NmN-125; Neuromedin N; NN; NmN; Neurotensin; NT; Tail peptide; Precursor 1436492 15489334 19122660 9530155 NA NEUT -1 Neurotensin/neuromedin N Large neuromedin N NmN-125 Neuromedin N NN NmN Neurotensin NT Tail peptide Precursor gene 1291 0.136068548786856 GOLM1 N - Not Matched Golgi apparatus IDA integral to plasma membrane TAS Golgi membrane protein 1; Golgi membrane protein GP73; Golgi phosphoprotein 2 10831838 12029628 12191016 12359426 12975309 15489334 16303743 16335952 16740002 21280149 NA GOLM1 1 Golgi membrane protein 1 Golgi membrane protein GP73 Golgi phosphoprotein 2 gene 1359 0.0146035958550651 APITD1 D - Genome Maintenance condensed chromosome kinetochore IEA cytosol TAS Fanconi anaemia nuclear complex IDA mitotic prometaphase TAS transcription initiation IEA DNA repair IDA resolution of meiotic joint molecules as recombinants IMP positive regulation of protein ubiquitination TAS collapsed replication fork processing IMP cell division IEA chromatin binding IDA DNA binding IDA Centromere protein S; CENP-S; Apoptosis-inducing TAF9-like domain-containing protein 1; FANCM-interacting histone fold protein 1; Fanconi anemia-associated polypeptide of 16 kDa .1016/j.molcel.2010.01.036 .1016/j.molcel.2010.01.039 15328517 15489334 16622419 16710414 19620631 22304917 NA CENPS 1 Centromere protein S CENP-S Apoptosis-inducing TAF9-like domain-containing protein 1 FANCM-interacting histone fold protein 1 Fanconi anemia-associated polypeptide of 16 kDa gene 1645 0.00623916627868205 FANCI D - Genome Maintenance plasma membrane IDA nucleoplasm TAS cell cycle IEA DNA repair TAS positive regulation of protein ubiquitination IDA DNA binding IEA Fanconi anemia group I protein; Protein FACI 11347906 14702039 15489334 16572171 16964243 17412408 17452773 17460694 17525332 18669648 18691976 19111657 19465922 19589784 20068231 20603015 21269460 21775430 NA FANCI 1 Fanconi anemia group I protein Protein FACI gene 1291 0.0359059239895385 C - Cellular Fate and Organization basal lamina TAS laminin-1 complex IEA regulation of cell migration IEA regulation of embryonic development IEA blood vessel development IEA brown fat cell differentiation IEA cell adhesion IEA regulation of cell adhesion IEA extracellular matrix structural constituent TAS Laminin subunit alpha-4; Laminin-14 subunit alpha; Laminin-8 subunit alpha; Laminin-9 subunit alpha; Precursor 14574404 15489334 19159218 7781776 7959779 8706685 9310354 NA LAMA4 -1 Laminin subunit alpha-4 Laminin-14 subunit alpha Laminin-8 subunit alpha Laminin-9 subunit alpha Precursor gene 1291 0.00556253733701826 LAMA2 C - Cellular Fate and Organization sarcolemma IEA laminin-1 complex IEA basement membrane IDA regulation of cell migration IEA regulation of embryonic development IEA positive regulation of synaptic transmission, cholinergic IEA muscle development TAS axon guidance IEA cell adhesion IEA regulation of cell adhesion IEA structural molecule activity TAS Laminin subunit alpha-2; Laminin M chain; Laminin-12 subunit alpha; Laminin-2 subunit alpha; Laminin-4 subunit alpha; Merosin heavy chain; Precursor 11591858 12552556 14574404 16335952 16959974 19159218 2185464 7535762 8294519 8910357 NA LAMA2 -1 Laminin subunit alpha-2 Laminin M chain Laminin-12 subunit alpha Laminin-2 subunit alpha Laminin-4 subunit alpha Merosin heavy chain Precursor gene 1291 0.379666317727118 A - Transport and Sensing membrane IEA extracellular region IEA multicellular organismal development IEA receptor activity IEA Semaphorin-3G; Semaphorin sem2; Precursor 14702039 15489334 NA SEM3G -1 Semaphorin-3G Semaphorin sem2 Precursor gene 1291 5.41764344545204E-5 SAPCD2 N - Not Matched cytoplasm IDA nucleolus IDA Suppressor APC domain-containing protein 2; Tumor specificity and mitosis phase-dependent expression protein; TS/MDEP; p42.3 15164053 15489334 17525738 NA SAPC2 1 Suppressor APC domain-containing protein 2 Tumor specificity and mitosis phase-dependent expression protein TS/MDEP p42.3 gene 1291 0.0333765276045545 ITM2B M - Other Metabolism plasma membrane IDA integral to organelle membrane IDA Golgi-associated vesicle membrane IDA nucleus IDA extracellular space IDA endosome membrane IEA apoptosis IEA induction of apoptosis IEA negative regulation of amyloid precursor protein biosynthetic process IDA nervous system development TAS beta-amyloid binding IPI ATP binding IEA Integral membrane protein 2B; Immature BRI2; imBRI2; Protein E25B; Transmembrane protein BRI; Bri; BRI2, membrane form; Mature BRI2; mBRI2; BRI2 intracellular domain; BRI2 ICD; BRI2C, soluble form; Bri23 peptide; Bri2-23; ABri23; C-terminal peptide; P23 peptide 10391242 10526337 10781099 10931946 14656991 15489334 15983050 16027166 16091362 17965014 18440095 18524908 18753367 19114711 19748705 20036644 21752865 22170863 22194595 NA ITM2B -1 Integral membrane protein 2B Immature BRI2 imBRI2 Protein E25B Transmembrane protein BRI Bri BRI2, membrane form Mature BRI2 mBRI2 BRI2 intracellular domain BRI2 ICD BRI2C, soluble form Bri23 peptide Bri2-23 ABri23 C-terminal peptide P23 peptide gene 1291 0.0947091236009375 PRMT5 D - Genome Maintenance protein complex IEA nucleus NAS cytosol TAS regulation of mitosis TAS cell proliferation TAS endothelial cell activation IMP negative regulation of transcription from RNA polymerase II promoter IEA spliceosomal snRNP biogenesis IMP transcription, DNA-dependent IEA chromatin binding IEA ribonucleoprotein binding IPI histone-arginine N-methyltransferase activity IEA protein-arginine omega-N symmetric methyltransferase activity IMP Protein arginine N-methyltransferase 5; 2.1.1.-; 72 kDa ICln-binding protein; Histone-arginine N-methyltransferase PRMT5; 2.1.1.125; Jak-binding protein 1; Shk1 kinase-binding protein 1 homolog; SKB1 homolog; SKB1Hs; Protein arginine N-methyltransferase 5, N-terminally processed 10531356 10734105 11152681 11747828 12101096 12508121 12665801 12718890 14702039 15485929 15489334 16087681 17709427 18404153 19054851 20159986 20810653 21258366 21269460 21917714 22269951 23071334 9556550 9843966 NA ANM5 1 Protein arginine N-methyltransferase 5 2.1.1.- 72 kDa ICln-binding protein Histone-arginine N-methyltransferase PRMT5 2.1.1.125 Jak-binding protein 1 Shk1 kinase-binding protein 1 homolog SKB1 homolog SKB1Hs Protein arginine N-methyltransferase 5, N-terminally processed gene 1291 2.32437802480824E-4 DOCK6 C - Cellular Fate and Organization perinuclear region IEA cytosol TAS blood coagulation TAS small GTPase mediated signal transduction IEA guanyl-nucleotide exchange factor activity IEA Dedicator of cytokinesis protein 6 10718198 12432077 15057824 15489334 17196961 18220336 18669648 21269460 21820096 NA DOCK6 -1 Dedicator of cytokinesis protein 6 gene 1291 0.0550793834643225 PRMT3 N - Not Matched cytoplasm NAS ribosome IEA cytosol IEA protein-arginine N-methyltransferase activity NAS zinc ion binding IEA protein-arginine omega-N asymmetric methyltransferase activity IEA Protein arginine N-methyltransferase 3; 2.1.1.-; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3 14702039 15489334 16554811 18669648 19690332 20068231 21269460 21406692 9642256 NA ANM3 1 Protein arginine N-methyltransferase 3 2.1.1.- Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3 gene 1291 4.29245351337125E-5 DOCK4 C - Cellular Fate and Organization membrane IDA stereocilium ISS cytosol IDA endomembrane system IEA small GTPase mediated signal transduction IEA guanyl-nucleotide exchange factor activity IEA Rac GTPase binding IDA Rac GTPase activator activity IDA Dedicator of cytokinesis protein 4 12432077 12628187 12853948 14702039 18669648 19690332 19807924 20679435 9872452 NA DOCK4 -1 Dedicator of cytokinesis protein 4 gene 1291 9.22127029133089E-4 A - Transport and Sensing transport vesicle IDA integral to membrane IEA Protein YIPF2; YIP1 family member 2 15489334 NA YIPF2 1 Protein YIPF2 YIP1 family member 2 gene 1291 0.0080442634822031 SEMA3B A - Transport and Sensing membrane IEA endoplasmic reticulum TAS extracellular region IEA axon guidance TAS cell-cell signaling TAS receptor activity IEA Semaphorin-3B; Sema A(V); Semaphorin-V; Sema V; Precursor 11085536 15489334 16641997 8633026 NA SEM3B -1 Semaphorin-3B Sema A(V) Semaphorin-V Sema V Precursor gene 1291 0.0584361174484631 A - Transport and Sensing transport vesicle IDA integral to membrane IEA Protein YIPF1; YIP1 family member 1 14702039 15489334 17974005 NA YIPF1 1 Protein YIPF1 YIP1 family member 1 gene 1291 0.1515508010446 CANT1 C - Cellular Fate and Organization endoplasmic reticulum membrane IEA integral to membrane IEA positive regulation of I-kappaB kinase/NF-kappaB cascade IMP proteoglycan biosynthetic process IMP calcium ion binding IEA uridine-diphosphatase activity IEA signal transducer activity IMP Soluble calcium-activated nucleotidase 1; SCAN-1; 3.6.1.6; Apyrase homolog; Putative MAPK-activating protein PM09; Putative NF-kappa-B-activating protein 107 12167635 12234496 12761501 14702039 15006348 15248776 15489334 19853239 20425819 21037275 21412251 21654728 22539336 NA CANT1 1 Soluble calcium-activated nucleotidase 1 SCAN-1 3.6.1.6 Apyrase homolog Putative MAPK-activating protein PM09 Putative NF-kappa-B-activating protein 107 gene 1291 0.0278647230913388 C - Cellular Fate and Organization meiosis I IEA cell proliferation TAS phosphoinositide-mediated signaling NAS regulation of cyclin-dependent protein kinase activity TAS spindle organization and biogenesis NAS cell division IEA cyclin-dependent protein kinase regulator activity IEA Cyclin-dependent kinases regulatory subunit 2; CKS-2 15164053 15489334 19608861 21269460 2227411 8211159 NA CKS2 1 Cyclin-dependent kinases regulatory subunit 2 CKS-2 gene 1902 4.53647777058396E-4 NA -1 gene 1291 0.0550793834643225 SND1 T - Transcription mitochondrion IEA melanosome IEA cytoplasm IDA nucleus TAS RNA-induced silencing complex IEA regulation of transcription, DNA-dependent IEA virus-host interaction IEA RNA-mediated gene silencing IEA transcription, DNA-dependent IEA transcription cofactor activity TAS nuclease activity IEA nucleic acid binding IEA Staphylococcal nuclease domain-containing protein 1; 100 kDa coactivator; EBNA2 coactivator p100; Tudor domain-containing protein 11; p100 co-activator 12234934 12917451 15489334 15592455 17081065 17081983 18669648 19608861 19690332 20068231 21269460 7651391 9809063 NA SND1 1 Staphylococcal nuclease domain-containing protein 1 100 kDa coactivator EBNA2 coactivator p100 Tudor domain-containing protein 11 p100 co-activator gene 1291 0.00121217492072079 NELFA T - Transcription NELF complex IDA RNA elongation from RNA polymerase II promoter TAS viral reproduction TAS multicellular organismal development TAS positive regulation of viral transcription TAS chromatin binding IEA Negative elongation factor A; NELF-A; Wolf-Hirschhorn syndrome candidate 2 protein 10199401 10409432 11150502 11280764 11387440 12563561 12612062 14702039 15489334 15815621 16964243 18669648 19690332 20068231 21269460 NA NELFA 1 Negative elongation factor A NELF-A Wolf-Hirschhorn syndrome candidate 2 protein gene 1291 0.0947091236009375 BDH1 R - Stress and Defence mitochondrial matrix NAS mitochondrial inner membrane IEA nucleus IDA response to corticosterone stimulus IEA response to nutrient IEA response to drug IEA response to ethanol IEA response to toxin IEA liver development IEA response to starvation IEA brain development IEA ketone body catabolic process TAS ketone body biosynthetic process TAS response to estradiol stimulus IEA cellular lipid metabolic process TAS response to cadmium ion IEA phospholipid binding IEA nucleotide binding IEA 3-hydroxybutyrate dehydrogenase activity IDA D-beta-hydroxybutyrate dehydrogenase, mitochondrial; BDH; 1.1.1.30; 3-hydroxybutyrate dehydrogenase; Precursor 15489334 1639787 NA BDH 1 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH 1.1.1.30 3-hydroxybutyrate dehydrogenase Precursor gene 1291 0.0849772701000822 T - Transcription nucleus IEA regulation of transcription, DNA-dependent IEA transcription, DNA-dependent IEA DNA binding TAS DNA-binding protein RFX2; Regulatory factor X 2 14702039 15057824 15489334 16959974 8289803 NA RFX2 -1 DNA-binding protein RFX2 Regulatory factor X 2 gene 1291 0.274618126864437 EMP2 C - Cellular Fate and Organization integral to membrane TAS cell proliferation TAS Epithelial membrane protein 2; EMP-2; Protein XMP 14702039 15489334 8917086 8996089 NA EMP2 -1 Epithelial membrane protein 2 EMP-2 Protein XMP gene 1291 0.308617760461342 EMP1 C - Cellular Fate and Organization plasma membrane IEA integral to membrane TAS epidermis development TAS cell proliferation TAS cell growth IEA Epithelial membrane protein 1; EMP-1; CL-20; Protein B4B; Tumor-associated membrane protein 14702039 15489334 8683158 8996089 9066625 9126480 NA EMP1 -1 Epithelial membrane protein 1 EMP-1 CL-20 Protein B4B Tumor-associated membrane protein gene 1291 2.60916519555271E-4 HGF D - Genome Maintenance platelet alpha granule lumen TAS extracellular region TAS extracellular space IEA negative regulation of apoptosis IEA positive regulation of cell migration IDA hepatocyte growth factor receptor signaling pathway IDA organ regeneration IEA platelet activation TAS positive regulation of peptidyl-tyrosine phosphorylation IDA positive regulation of phosphoinositide 3-kinase cascade IDA epithelial to mesenchymal transition TAS positive regulation of osteoblast differentiation NAS liver development IEA activation of MAPK activity IEA mitosis NAS positive regulation of transcription from RNA polymerase II promoter NAS platelet degranulation TAS myoblast proliferation IEA negative regulation of caspase activity IDA catalytic activity IEA chemoattractant activity IDA growth factor activity NAS Hepatocyte growth factor; Hepatopoietin-A; Scatter factor; SF; Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain; Precursor 12690205 1280830 12853948 1321034 1482348 15167892 15489334 1720571 1824873 1826653 1826837 1831266 1831432 1832556 19576567 20624990 2145836 2528952 2531289 8662798 9493272 9817840 NA HGF -1 Hepatocyte growth factor Hepatopoietin-A Scatter factor SF Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain Precursor gene 1291 0.00128050315194328 IGSF10 C - Cellular Fate and Organization extracellular region IEA ossification IEA multicellular organismal development IEA cell differentiation IEA Immunoglobulin superfamily member 10; IgSF10; Calvaria mechanical force protein 608; CMF608; Precursor 14702039 14962803 15489334 NA IGS10 -1 Immunoglobulin superfamily member 10 IgSF10 Calvaria mechanical force protein 608 CMF608 Precursor gene 1291 0.0079629809758649 M - Other Metabolism plasma membrane IDA cytosol TAS plasma membrane fusion TAS positive regulation of receptor recycling IDA synaptic transmission TAS exocytosis TAS protein transport IEA potassium ion transport IEA ATPase activity, coupled IEA ATP binding IEA protein complex binding IDA metal ion binding IEA Vesicle-fusing ATPase; 3.6.4.6; N-ethylmaleimide-sensitive fusion protein; NEM-sensitive fusion protein; Vesicular-fusion protein NSF 14702039 15489334 16625196 21269460 NA NSF 1 Vesicle-fusing ATPase 3.6.4.6 N-ethylmaleimide-sensitive fusion protein NEM-sensitive fusion protein Vesicular-fusion protein NSF gene 1291 0.00523697495549585 BTG2 D - Genome Maintenance associative learning IEA dentate gyrus development IEA negative regulation of apoptosis IEA negative regulation of cell proliferation TAS central nervous system neuron development IEA response to peptide hormone stimulus IEA anterior/posterior pattern formation IEA neurite development IMP response to mechanical stimulus IEA DNA repair TAS response to electrical stimulus IEA protein amino acid methylation IEA Protein BTG2; BTG family member 2; NGF-inducible anti-proliferative protein PC3 11267995 11814693 12771185 15489334 15788397 16710414 18773938 8944033 NA BTG2 -1 Protein BTG2 BTG family member 2 NGF-inducible anti-proliferative protein PC3 gene 1291 0.283263917962596 SNCA M - Other Metabolism rough endoplasmic reticulum IEA axon IDA perinuclear region IDA cell junction IEA Golgi apparatus IEA plasma membrane IDA inclusion body IDA nucleus IDA actin cytoskeleton IDA growth cone IDA cytosol IDA synaptic vesicle IEA mitochondrion IEA nuclear outer membrane IEA terminal button IEA ribosome IEA fibril IDA cell cortex IDA cytoplasmic vesicle membrane IEA adult locomotory behavior IEA regulation of macrophage activation IEA negative regulation of transporter activity IDA response to iron(II) ion IDA behavioral response to cocaine IEA negative regulation of histone acetylation IDA regulation of acyl-CoA biosynthetic process IEA regulation of dopamine secretion TAS dopamine biosynthetic process TAS protein destabilization IDA receptor internalization IDA positive regulation of endocytosis IDA negative regulation of exocytosis IMP negative regulation of norepinephrine uptake IDA dopamine uptake TAS regulation of locomotion IEA negative regulation of neuron apoptosis IEA negative regulation of dopamine uptake IDA regulation of long-term neuronal synaptic plasticity IEA negative regulation of dopamine metabolic process IEA fatty acid metabolic process IEA positive regulation of receptor recycling IDA response to magnesium ion IDA response to lipopolysaccharide IDA fibril organization and biogenesis TAS microglial cell activation IEA positive regulation of release of sequestered calcium ion into cytosol IDA neutral lipid metabolic process IEA negative regulation of microtubule polymerization IDA negative regulation of apoptosis IMP caspase activation IDA response to drug IEA aging IEA synaptic vesicle endocytosis ISS regulation of glutamate secretion IEA negative regulation of monooxygenase activity IDA synapse organization and biogenesis IEA ATP synthesis coupled electron transport (sensu Eukaryota) IEA negative regulation of serotonin uptake IDA negative regulation of protein amino acid phosphorylation IEA mitochondrial membrane organization and biogenesis IEA positive regulation of neurotransmitter secretion IEA phospholipid metabolic process IEA phosphoprotein binding IDA histone binding IDA magnesium ion binding IDA phospholipid binding IEA copper ion binding IDA calcium ion binding IDA oxidoreductase activity IDA tau protein binding IDA zinc ion binding IDA ferrous iron binding IDA caspase inhibitor activity IDA Alpha-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP 10617630 10852916 11156617 11162638 11813001 11821392 12558071 12859192 12859200 12893833 14702039 14755719 15282274 15489334 15498564 15615727 19722699 21269460 21319811 22407793 7601450 7802671 8248242 9197268 9462735 NA SYUA -1 Alpha-synuclein Non-A beta component of AD amyloid Non-A4 component of amyloid precursor NACP gene 1291 0.0126331677876299 C - Cellular Fate and Organization cell junction IEA plasma membrane IDA platelet alpha granule membrane TAS integral to membrane IEA extracellular space IDA phagocytosis IDA signal transduction TAS diapedesis IDA cell recognition TAS platelet degranulation TAS platelet activation TAS cell adhesion IEA Platelet endothelial cell adhesion molecule; PECAM-1; EndoCAM; GPIIA'; PECA1; CD31; Precursor 11791967 12110892 12433657 15489334 16625196 1690453 1700999 17139370 18088087 18388311 18672896 18710921 1874786 19159218 19342684 19349973 19690332 2351935 7994021 8226797 8532023 9298995 NA PECA1 -1 Platelet endothelial cell adhesion molecule PECAM-1 EndoCAM GPIIA' PECA1 CD31 Precursor gene 1291 0.0439244987968563 P2RY14 A - Transport and Sensing plasma membrane TAS integral to membrane NAS UDP-activated nucleotide receptor activity NAS purinergic nucleotide receptor activity, G-protein coupled IEA P2Y purinoceptor 14; P2Y14; G-protein coupled receptor 105; UDP-glucose receptor 10753868 11524702 15489334 16959974 7584026 NA P2Y14 -1 P2Y purinoceptor 14 P2Y14 G-protein coupled receptor 105 UDP-glucose receptor gene 1291 6.17614106217859E-5 D - Genome Maintenance cytoplasm TAS centrosome IEA nuclear envelope TAS positive regulation of GTPase activity IEA signal transduction TAS viral reproduction TAS positive regulation of mitotic centrosome separation IEA intracellular transport IEA spindle organization and biogenesis IEA Ran GTPase binding TAS GDP-dissociation inhibitor activity TAS GTPase activator activity IEA Ran-specific GTPase-activating protein; Ran-binding protein 1; RanBP1 15461802 16959974 18669648 19608861 19690332 20068231 21269460 21406692 7616957 7882974 NA RANG 1 Ran-specific GTPase-activating protein Ran-binding protein 1 RanBP1 gene 1291 0.0914604721306057 YTHDF1 YTH domain family protein 1; Dermatomyositis associated with cancer putative autoantigen 1; DACA-1 11780052 14702039 15489334 17974005 18669648 18691976 20068231 21269460 21406692 NA YTHD1 1 YTH domain family protein 1 Dermatomyositis associated with cancer putative autoantigen 1 DACA-1 gene 1291 3.11597142828092E-4 CHL1 C - Cellular Fate and Organization plasma membrane IEA extracellular matrix (sensu Metazoa) IEA apical part of cell IEA integral to membrane TAS dendrite IEA signal transduction TAS adult locomotory behavior IEA negative regulation of neuron apoptosis IEA cognition IEA axon guidance TAS neuron migration IEA cell adhesion TAS Neural cell adhesion molecule L1-like protein; Close homolog of L1; Processed neural cell adhesion molecule L1-like protein; Precursor 15489334 16335952 16641997 16959974 9799093 NA CHL1 -1 Neural cell adhesion molecule L1-like protein Close homolog of L1 Processed neural cell adhesion molecule L1-like protein Precursor gene 1361 5.6569030400881E-4 T - Transcription protein complex IEA nucleus IEA chromatin TAS positive regulation of osteoblast differentiation IEA osteoblast development IEA regulation of transcription from RNA polymerase II promoter TAS transcription from RNA polymerase II promoter IEA positive regulation of transcription from RNA polymerase II promoter IEA aging IEA response to lipopolysaccharide IEA circadian rhythm IEA response to peptide hormone stimulus IEA response to light stimulus IEA response to mechanical stimulus IEA sequence-specific DNA binding IEA double-stranded DNA binding IEA transcription factor activity IEA Transcription factor jun-D 18669648 1903194 19369195 19690332 20068231 2112242 9989505 NA JUND -1 Transcription factor jun-D TF 1302 1.58135607226104E-4 D - Genome Maintenance nucleoplasm TAS chromatin TAS response to corticosterone stimulus IEA transcription initiation from RNA polymerase II promoter TAS response to drug IEA positive regulation of cell differentiation IEA osteoclast differentiation IEA response to peptide hormone stimulus IEA trophectodermal cell differentiation IEA response to cAMP IEA osteoblast differentiation IEA response to mechanical stimulus IEA decidualization IEA positive regulation of transcription from RNA polymerase II promoter TAS regulation of cell cycle IEA transforming growth factor beta receptor signaling pathway TAS response to light stimulus IEA vasculogenesis IEA transcription factor activity IEA double-stranded DNA binding IEA transcription corepressor activity TAS transcription coactivator activity TAS DNA binding TAS Transcription factor jun-B 15489334 16387660 18669648 19690332 20068231 2112242 21406692 2513129 8530030 NA JUNB -1 Transcription factor jun-B gene 1291 1.0 USF2 T - Transcription nucleus IDA late viral mRNA transcription IC lactation IEA positive regulation of transcription from RNA polymerase II promoter IMP positive regulation of transcription from RNA polymerase II promoter by glucose IMP transcription, DNA-dependent IEA sequence-specific DNA binding IDA transcription factor activity TAS double-stranded DNA binding IEA RNA polymerase II transcription factor activity, enhancer binding IMP Upstream stimulatory factor 2; Class B basic helix-loop-helix protein 12; bHLHb12; FOS-interacting protein; FIP; Major late transcription factor 2; Upstream transcription factor 2 1450663 15057824 15489334 1589769 8576131 8954795 NA USF2 0 Upstream stimulatory factor 2 Class B basic helix-loop-helix protein 12 bHLHb12 FOS-interacting protein FIP Major late transcription factor 2 Upstream transcription factor 2 TF 1291 0.162830200325742 MTCH1 C - Cellular Fate and Organization mitochondrion IMP mitochondrial inner membrane IEA integral to membrane IEA positive regulation of apoptosis IEP caspase activation IMP neuronal ion channel clustering NAS transport IEA regulation of signal transduction NAS Mitochondrial carrier homolog 1; Presenilin-associated protein 10551805 12377771 12975309 14574404 14702039 15489334 21269460 NA MTCH1 -1 Mitochondrial carrier homolog 1 Presenilin-associated protein gene 1291 1.0 USF1 T - Transcription transcription factor complex IDA response to hypoxia IMP late viral mRNA transcription IDA negative regulation of fibrinolysis IC glucose metabolic process IEA positive regulation of transcription from RNA polymerase II promoter by glucose IMP glucose homeostasis TAS response to UV ISS sequence-specific DNA binding IDA double-stranded DNA binding IEA RNA polymerase II transcription factor activity, enhancer binding IDA protein homodimerization activity TAS Upstream stimulatory factor 1; Class B basic helix-loop-helix protein 11; bHLHb11; Major late transcription factor 1 14573800 14702039 14991056 15489334 16710414 17974005 2249772 8306960 NA USF1 0 Upstream stimulatory factor 1 Class B basic helix-loop-helix protein 11 bHLHb11 Major late transcription factor 1 TF 1291 0.0381457414750155 ABHD11 N - Not Matched mitochondrion IEA hydrolase activity IEA Alpha/beta hydrolase domain-containing protein 11; Abhydrolase domain-containing protein 11; 3.-.-.-; Williams-Beuren syndrome chromosomal region 21 protein 12073013 12853948 15489334 15498874 NA ABHDB 1 Alpha/beta hydrolase domain-containing protein 11 Abhydrolase domain-containing protein 11 3.-.-.- Williams-Beuren syndrome chromosomal region 21 protein gene 1291 0.0550793834643225 EZH2 D - Genome Maintenance ESC/E(Z) complex IDA pronucleus IEA S phase of mitotic cell cycle IEA negative regulation of epidermal cell differentiation IEA cerebellar cortex development IEA negative regulation of retinoic acid receptor signaling pathway IMP regulation of cell proliferation IEA regulation of gliogenesis IEA regulation of protein amino acid phosphorylation IEA negative regulation of striated muscle cell differentiation IEA negative regulation of transcription, DNA-dependent IMP transcription, DNA-dependent IEA sequence-specific DNA binding IEA chromatin binding IEA DNA binding TAS histone-lysine N-methyltransferase activity IEA histone methyltransferase activity IDA Histone-lysine N-methyltransferase EZH2; 2.1.1.43; ENX-1; Enhancer of zeste homolog 2; Lysine N-methyltransferase 6 10581039 11158321 12101246 12351676 12435631 12853948 14532106 14702039 15099518 15208672 15225548 15231737 15385962 15489334 15684044 16179254 16224021 16357870 16431907 16618801 16936726 16964243 17081983 17200670 17210787 17344414 18086877 18220336 18285464 18628979 18669648 18691976 19026781 19690332 20068231 20081860 20935635 21406692 21828135 22177091 8649418 8954776 9214638 9499421 9584199 NA EZH2 1 Histone-lysine N-methyltransferase EZH2 2.1.1.43 ENX-1 Enhancer of zeste homolog 2 Lysine N-methyltransferase 6 gene 1291 0.00458749974480071 CCT6A P - Translation chaperonin-containing T-complex IEA microtubule IDA cytosol TAS posttranslational protein folding TAS unfolded protein binding TAS ATP binding IEA T-complex protein 1 subunit zeta; TCP-1-zeta; Acute morphine dependence-related protein 2; CCT-zeta-1; HTR3; Tcp20 12665801 12853948 1352881 14532270 15489334 19608861 21269460 8034610 NA TCPZ 1 T-complex protein 1 subunit zeta TCP-1-zeta Acute morphine dependence-related protein 2 CCT-zeta-1 HTR3 Tcp20 gene 1291 0.00691815401314746 EZH1 T - Transcription ESC/E(Z) complex IDA negative regulation of transcription from RNA polymerase II promoter IEA anatomical structure morphogenesis TAS transcription, DNA-dependent IEA chromatin binding TAS histone lysine N-methyltransferase activity (H3-K27 specific) IEA Histone-lysine N-methyltransferase EZH1; 2.1.1.43; ENX-2; Enhancer of zeste homolog 1 14702039 15489334 16625196 19026781 7490091 8921387 9205841 9473645 NA EZH1 -1 Histone-lysine N-methyltransferase EZH1 2.1.1.43 ENX-2 Enhancer of zeste homolog 1 gene 1291 0.0886312797080639 N - Not Matched integral to membrane IEA UPF0668 protein C10orf76 14702039 15164054 15489334 NA CJ076 -1 UPF0668 protein C10orf76 gene 1291 0.018030555180901 FAT4 C - Cellular Fate and Organization plasma membrane IEA integral to membrane IEA homophilic cell adhesion IEA calcium ion binding IEA Protocadherin Fat 4; hFat4; Cadherin family member 14; FAT tumor suppressor homolog 4; Fat-like cadherin protein FAT-J; Precursor 12880961 14702039 15003449 15815621 16865240 17974005 NA FAT4 -1 Protocadherin Fat 4 hFat4 Cadherin family member 14 FAT tumor suppressor homolog 4 Fat-like cadherin protein FAT-J Precursor gene 1291 0.024546100231356 FAT3 C - Cellular Fate and Organization plasma membrane IEA integral to membrane IEA multicellular organismal development IEA homophilic cell adhesion IEA calcium ion binding IEA Protocadherin Fat 3; hFat3; Cadherin family member 15; FAT tumor suppressor homolog 3; Precursor 11811999 15489334 16554811 16865240 NA FAT3 -1 Protocadherin Fat 3 hFat3 Cadherin family member 15 FAT tumor suppressor homolog 3 Precursor gene 1291 0.00126810059466535 AP1S2 A - Transport and Sensing coated pit IEA Golgi membrane TAS lysosomal membrane TAS membrane coat adaptor complex TAS cytoplasmic vesicle membrane TAS cytosol TAS antigen processing and presentation of exogenous peptide antigen via MHC class II TAS post-Golgi vesicle-mediated transport TAS viral reproduction TAS intracellular protein transport IEA membrane organization and biogenesis TAS endocytosis IEA regulation of antiviral response by virus TAS protein transporter activity IEA AP-1 complex subunit sigma-2; Adapter-related protein complex 1 sigma-1B subunit; Adaptor protein complex AP-1 sigma-1B subunit; Clathrin assembly protein complex 1 sigma-1B small chain; Golgi adaptor HA1/AP1 adaptin sigma-1B subunit; Sigma 1B subunit of AP-1 clathrin; Sigma-adaptin 1B; Sigma1B-adaptin 15471854 15489334 17186471 21269460 9733768 NA AP1S2 -1 AP-1 complex subunit sigma-2 Adapter-related protein complex 1 sigma-1B subunit Adaptor protein complex AP-1 sigma-1B subunit Clathrin assembly protein complex 1 sigma-1B small chain Golgi adaptor HA1/AP1 adaptin sigma-1B subunit Sigma 1B subunit of AP-1 clathrin Sigma-adaptin 1B Sigma1B-adaptin gene 1291 0.0112763430619318 AP1S1 A - Transport and Sensing coated pit IEA AP-1 adaptor complex TAS lysosomal membrane TAS cytosol TAS antigen processing and presentation of exogenous peptide antigen via MHC class II TAS post-Golgi vesicle-mediated transport TAS viral reproduction TAS response to virus IEP intracellular protein transport IEA receptor-mediated endocytosis TAS membrane organization and biogenesis TAS regulation of antiviral response by virus TAS protein transporter activity IEA AP-1 complex subunit sigma-1A; Adapter-related protein complex 1 sigma-1A subunit; Adaptor protein complex AP-1 sigma-1A subunit; Clathrin assembly protein complex 1 sigma-1A small chain; Clathrin coat assembly protein AP19; Golgi adaptor HA1/AP1 adaptin sigma-1A subunit; HA1 19 kDa subunit; Sigma 1a subunit of AP-1 clathrin; Sigma-adaptin 1A; Sigma1A-adaptin 12853948 14702039 15489334 16548883 18691976 20068231 21269460 9733768 NA AP1S1 1 AP-1 complex subunit sigma-1A Adapter-related protein complex 1 sigma-1A subunit Adaptor protein complex AP-1 sigma-1A subunit Clathrin assembly protein complex 1 sigma-1A small chain Clathrin coat assembly protein AP19 Golgi adaptor HA1/AP1 adaptin sigma-1A subunit HA1 19 kDa subunit Sigma 1a subunit of AP-1 clathrin Sigma-adaptin 1A Sigma1A-adaptin gene 1291 0.0979480891694494 FNDC1 G - Amino Acid Metabolism mitochondrial membrane IEA plasma membrane IEA intercellular junction IEA extracellular region IEA positive regulation of protein amino acid phosphorylation IEA regulation of protein transport IEA Fibronectin type III domain-containing protein 1; Activation-associated cDNA protein; Expressed in synovial lining protein; Precursor 11347906 14574404 15489334 16098131 17974005 9704633 NA FNDC1 1 Fibronectin type III domain-containing protein 1 Activation-associated cDNA protein Expressed in synovial lining protein Precursor gene 1291 0.401766357395265 AXL D - Genome Maintenance cell surface IDA integral to plasma membrane TAS extracellular space IDA phagocytosis IDA positive regulation of protein kinase B signaling cascade IEA apoptotic cell clearance IEA platelet activation IEA negative regulation of tumor necrosis factor-alpha production IEA menstrual cycle IEA positive regulation of natural killer cell differentiation IDA spermatogenesis IEA negative regulation of neuron apoptosis IEA inflammatory response IEA positive regulation of cytokine and chemokine mediated signaling pathway IDA blood vessel remodeling IEA cellular response to extracellular stimulus IEA innate immune response IEA protein kinase B signaling cascade IEA negative regulation of lymphocyte activation IEA natural killer cell differentiation IEA cell maturation IEP forebrain cell migration IEA neuron migration IEA negative regulation of interferon-gamma production IDA enzyme linked receptor protein signaling pathway IEA phosphatidylserine binding IDA transmembrane receptor protein tyrosine kinase activity TAS ATP binding IEA Tyrosine-protein kinase receptor UFO; 2.7.10.1; AXL oncogene; Precursor 10403904 11484958 12364394 12470648 12490074 15057824 15489334 15507525 15733062 15958209 16362042 1656220 17005688 17344846 18346204 1834974 18691976 18840707 19815557 2247464 7854420 7896447 8247543 8621659 9178760 NA UFO -1 Tyrosine-protein kinase receptor UFO 2.7.10.1 AXL oncogene Precursor gene 1291 0.0118402561230045 C - Cellular Fate and Organization Golgi apparatus IDA microtubule organizing center IEA stereocilium IEA actin cytoskeleton IDA cell cortex IEA chloride transport IDA pregnancy TAS protein localization IEA sensory perception of sound IEA diet induced thermogenesis IEA regulation of balance IEA voltage-gated chloride channel activity IEA Chloride intracellular channel protein 5 10793131 12163479 14574404 14702039 15184393 15489334 16303743 18028448 20335315 NA CLIC5 -1 Chloride intracellular channel protein 5 gene 1291 0.00278826064098995 MRTO4 N - Not Matched nuclear membrane IDA nucleolus IDA ribosome biogenesis and assembly IEA mRNA turnover protein 4 homolog 12429849 14702039 15489334 16710414 21269460 NA MRT4 1 mRNA turnover protein 4 homolog gene 1396 0.0100311826516055 D - Genome Maintenance vacuole IEA perinuclear region IDA centrosome IDA plasma membrane IDA cell surface IDA midbody IDA apical part of cell IDA actin cytoskeleton TAS nuclear matrix IDA cytosol IDA mitochondrion IDA microvillus IDA intercellular junction IDA cytoplasmic vesicle membrane IEA fertilization IEA negative regulation of cell migration IDA body growth IEA regulation of cytoskeleton organization and biogenesis NAS endothelial cell morphogenesis IEA vacuolar acidification IEA keratinocyte differentiation IMP establishment and/or maintenance of apical/basal cell polarity NAS angiogenesis IEA branching morphogenesis of a tube IEA voltage-gated chloride channel activity IEA chloride channel activity TAS Chloride intracellular channel protein 4; Intracellular chloride ion channel protein p64H1 10070163 10191309 10793131 11230166 12163372 12163479 14569596 15489334 16176272 16239224 16581025 17200346 17636002 18302930 19247789 19608861 21269460 21406692 NA CLIC4 -1 Chloride intracellular channel protein 4 Intracellular chloride ion channel protein p64H1 gene 1291 5.59962278657706E-4 PPAP2C C - Cellular Fate and Organization plasma membrane TAS integral to membrane IEA sphingolipid biosynthetic process TAS phospholipid metabolic process TAS phosphoprotein phosphatase activity TAS phosphatidate phosphatase activity IEA Lipid phosphate phosphohydrolase 2; 3.1.3.4; PAP2-gamma; PAP2-G; Phosphatidate phosphohydrolase type 2c; Phosphatidic acid phosphatase 2c; PAP-2c; PAP2c 15057824 15489334 9570154 9607309 9705349 NA LPP2 1 Lipid phosphate phosphohydrolase 2 3.1.3.4 PAP2-gamma PAP2-G Phosphatidate phosphohydrolase type 2c Phosphatidic acid phosphatase 2c PAP-2c PAP2c gene 1291 0.0211472487140471 PPAP2B C - Cellular Fate and Organization Golgi apparatus IEA plasma membrane TAS adherens junction TAS integral to membrane IEA germ cell migration TAS positive regulation of transcription factor activity IDA blood vessel development IEA regulation of Wnt receptor signaling pathway IEA sphingolipid biosynthetic process TAS protein stabilization IDA negative regulation of protein amino acid phosphorylation IDA positive regulation of peptidyl-tyrosine phosphorylation IEA phospholipid metabolic process TAS gastrulation (sensu Deuterostomia) IEA lipid phosphatase activity IEA phosphoprotein phosphatase activity TAS phosphatidate phosphatase activity IEA Lipid phosphate phosphohydrolase 3; 3.1.3.4; PAP2-beta; Phosphatidate phosphohydrolase type 2b; Phosphatidic acid phosphatase 2b; PAP-2b; PAP2b; Vascular endothelial growth factor and type I collagen-inducible protein; VCIP 12660161 14702039 14725715 15489334 18669648 18691976 21406692 9110174 9305923 9705349 NA LPP3 -1 Lipid phosphate phosphohydrolase 3 3.1.3.4 PAP2-beta Phosphatidate phosphohydrolase type 2b Phosphatidic acid phosphatase 2b PAP-2b PAP2b Vascular endothelial growth factor and type I collagen-inducible protein VCIP gene 1292 0.0738497266337713 ZBTB20 N - Not Matched nucleus IDA zinc ion binding IEA DNA binding IEA Zinc finger and BTB domain-containing protein 20; Dendritic-derived BTB/POZ zinc finger protein; Zinc finger protein 288 11230166 11352661 15489334 17974005 19690332 20068231 NA ZBT20 -1 Zinc finger and BTB domain-containing protein 20 Dendritic-derived BTB/POZ zinc finger protein Zinc finger protein 288 gene 1291 0.0143097055158031 GLDN C - Cellular Fate and Organization collagen IEA plasma membrane IEA integral to membrane IEA extracellular space IEA cell differentiation IEA nervous system development IEA Gliomedin 12975309 14702039 16039564 17974005 NA GLDN -1 Gliomedin gene 1291 0.0496105166462564 GPIHBP1 A - Transport and Sensing intracellular IEA basolateral plasma membrane ISS apical plasma membrane ISS integral to membrane IEA anchored to external side of plasma membrane IDA cholesterol homeostasis ISS transcytosis ISS lipid transport IEA protein stabilization ISS protein import ISS intracellular protein transport ISS positive regulation of lipoprotein lipase activity IMP high-density lipoprotein binding IEA protein carrier activity ISS lipid binding IEA Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1; GPI-HBP1; GPI-anchored HDL-binding protein 1; High density lipoprotein-binding protein 1; Precursor 15489334 17883852 17997385 19304573 NA HDBP1 -1 Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 GPI-HBP1 GPI-anchored HDL-binding protein 1 High density lipoprotein-binding protein 1 Precursor gene 1291 0.0947091236009375 AVL9 N - Not Matched integral to membrane IEA cell migration IDA Late secretory pathway protein AVL9 homolog 12853948 14702039 18669648 21269460 22595670 9039502 NA AVL9 1 Late secretory pathway protein AVL9 homolog gene 1291 0.0103440759589067 ITIH5 F - Protein Fate extracellular region IEA hyaluronan metabolic process IEA serine-type endopeptidase inhibitor activity IEA Inter-alpha-trypsin inhibitor heavy chain H5; ITI heavy chain H5; ITI-HC5; Inter-alpha-inhibitor heavy chain 5; Precursor 11853319 12975309 14702039 14744536 15164054 15498874 17974005 NA ITIH5 -1 Inter-alpha-trypsin inhibitor heavy chain H5 ITI heavy chain H5 ITI-HC5 Inter-alpha-inhibitor heavy chain 5 Precursor gene 1291 0.300262688080211 FOXF2 D - Genome Maintenance transcription factor complex IDA regulation of transcription factor activity IBA pattern specification process IBA extracellular matrix organization and biogenesis IEA positive regulation of transcription from RNA polymerase II promoter IDA palate development IMP genitalia development IMP epithelial to mesenchymal transition NAS embryonic development IBA embryonic gut development IEA negative regulation of transcription, DNA-dependent IEA embryonic eye morphogenesis (sensu Actinopterygii) IEA establishment of polarity of embryonic epithelium IEA sequence-specific DNA binding IDA double-stranded DNA binding IBA DNA bending activity IBA RNA polymerase II transcription factor activity, enhancer binding IBA Forkhead box protein F2; Forkhead-related activator 2; FREAC-2; Forkhead-related protein FKHL6; Forkhead-related transcription factor 2 14574404 7957066 8626802 9722567 9799607 NA FOXF2 -1 Forkhead box protein F2 Forkhead-related activator 2 FREAC-2 Forkhead-related protein FKHL6 Forkhead-related transcription factor 2 gene 1291 0.00375315258666234 FOXF1 D - Genome Maintenance transcription factor complex IBA pattern specification process IBA determination of left/right symmetry IEA somitogenesis IEA smoothened signaling pathway IEA regulation of transcription factor activity IBA cell-cell adhesion IEA extracellular matrix organization and biogenesis IEA positive regulation of transcription from RNA polymerase II promoter IEA lateral mesodermal cell differentiation IEA negative regulation of mast cell degranulation IEA positive regulation of cell migration IEA regulation of smooth muscle cell differentiation IEA alveolus development IEA positive regulation of mesenchymal cell proliferation IEA negative regulation of transcription from RNA polymerase II promoter IEA embryonic development (sensu Mammalia) IMP establishment of epithelial cell polarity IEA pancreas development IMP midgut development IMP negative regulation of inflammatory response IEA embryonic foregut morphogenesis IEA positive regulation of transcription, DNA-dependent IDA embryonic ectodermal gut morphogenesis IMP vasculogenesis IEA smooth muscle cell differentiation IEA sequence-specific DNA binding ISS double-stranded DNA binding IBA DNA bending activity IBA RNA polymerase II transcription factor activity, enhancer binding IBA transcription factor binding IBA Forkhead box protein F1; Forkhead-related activator 1; FREAC-1; Forkhead-related protein FKHL5; Forkhead-related transcription factor 1 14702039 15489334 15616553 19500772 7957066 8626802 9769171 NA FOXF1 -1 Forkhead box protein F1 Forkhead-related activator 1 FREAC-1 Forkhead-related protein FKHL5 Forkhead-related transcription factor 1 gene 1291 0.110807554138766 M - Other Metabolism cytoplasm IEA microtubule associated complex IEA microtubule IEA positive regulation of cell-cell adhesion IEA establishment of cell polarity IEA microtubule-based movement IEA microtubule motor activity IEA ATP binding IEA Kinesin-like protein KIF26B 14702039 15489334 NA KI26B 1 Kinesin-like protein KIF26B gene 1291 4.01696623728864E-4 Leucine zipper transcription factor-like protein 1 11352561 15489334 17974005 21269460 NA LZTL1 -1 Leucine zipper transcription factor-like protein 1 gene 1291 0.0849340188103281 MCM10 D - Genome Maintenance cytoplasm IDA nucleolus IDA nucleoplasm TAS DNA replication TAS G1/S transition of mitotic cell cycle TAS cell cycle checkpoint TAS M/G1 transition of mitotic cell cycle TAS DNA binding IEA metal ion binding IEA Protein MCM10 homolog; HsMCM10 11095689 11230166 11602595 14702039 15136575 15164054 15489334 17370265 17525332 17699597 17761813 18669648 19608746 19690332 19696745 NA MCM10 1 Protein MCM10 homolog HsMCM10 gene 1291 4.58870887597033E-4 HMBS N - Not Matched cytosol TAS peptidyl-pyrromethane cofactor linkage IEA protoporphyrinogen IX biosynthetic process IEA heme biosynthetic process IC hydroxymethylbilane synthase activity IDA Porphobilinogen deaminase; PBG-D; 2.5.1.61; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase 10453740 10494093 10502788 10602775 10657149 10782018 11013452 11030413 11399210 11857754 12372055 12406973 1301948 1427766 14669009 14702039 1496994 14970743 15489334 15669678 1714233 18936296 19207107 21269460 2243128 2609111 2875434 3422427 3816774 7757070 7866402 7916736 7962538 8081367 8262523 8268934 8270254 8270256 8401516 8825929 9199558 9225970 9463797 9654202 NA HEM3 1 Porphobilinogen deaminase PBG-D 2.5.1.61 Hydroxymethylbilane synthase HMBS Pre-uroporphyrinogen synthase gene 1291 0.0750711142623216 PRSS22 F - Protein Fate extracellular region IEA proteolysis IEA serine-type endopeptidase activity IEA Brain-specific serine protease 4; BSSP-4; 3.4.21.-; Serine protease 22; Serine protease 26; Tryptase epsilon; Precursor 11602603 12975309 15489334 15616553 NA BSSP4 1 Brain-specific serine protease 4 BSSP-4 3.4.21.- Serine protease 22 Serine protease 26 Tryptase epsilon Precursor gene 1291 6.38402765260165E-4 S1PR1 C - Cellular Fate and Organization plasma membrane TAS integral to membrane IEA external side of plasma membrane IEA positive regulation of cell migration IEA angiogenesis IEA transmission of nerve impulse IEA G-protein signaling, adenylate cyclase inhibiting pathway IEA regulation of cell adhesion IEA positive regulation of smooth muscle cell proliferation IEA positive regulation of positive chemotaxis IEA negative regulation of stress fiber formation IEA positive regulation of Ras GTPase activity IEA brain development IEA elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) IEA neuron differentiation IEA positive regulation of transcription from RNA polymerase II promoter IEA endothelial cell differentiation IEA cell adhesion TAS sphingolipid binding IEA G-protein coupled receptor activity TAS Sphingosine 1-phosphate receptor 1; S1P receptor 1; S1P1; Endothelial differentiation G-protein coupled receptor 1; Sphingosine 1-phosphate receptor Edg-1; S1P receptor Edg-1; CD363 10383399 10982820 11230698 11583630 14702039 15489334 16710414 2160972 8626678 9409733 9488656 NA S1PR1 -1 Sphingosine 1-phosphate receptor 1 S1P receptor 1 S1P1 Endothelial differentiation G-protein coupled receptor 1 Sphingosine 1-phosphate receptor Edg-1 S1P receptor Edg-1 CD363 gene 1291 0.106951875741358 NR2F1 T - Transcription nucleoplasm TAS transcription initiation from RNA polymerase II promoter TAS negative regulation of transcription from RNA polymerase II promoter IDA forebrain development IEA neuron migration IEA sequence-specific DNA binding IDA transcription coactivator activity TAS steroid hormone receptor activity IEA zinc ion binding IEA ligand-dependent nuclear receptor activity TAS COUP transcription factor 1; COUP-TF1; COUP transcription factor I; COUP-TF I; Nuclear receptor subfamily 2 group F member 1; V-erbA-related protein 3; EAR-3 10207062 10644740 11682620 15489334 2739739 2905047 NA COT1 -1 COUP transcription factor 1 COUP-TF1 COUP transcription factor I COUP-TF I Nuclear receptor subfamily 2 group F member 1 V-erbA-related protein 3 EAR-3 gene 1291 1.53920060472355E-4 GPR89B A - Transport and Sensing Golgi membrane IEA integral to membrane IEA protein transport IEA voltage-gated ion channel activity IEA Golgi pH regulator B; Protein GPR89B 11042152 16710414 17974005 18794847 19135895 NA GPHRB 1 Golgi pH regulator B Protein GPR89B gene 1629 0.0051926145583678 BIRC5 D - Genome Maintenance cytoplasmic microtubule IDA centriole IDA microtubule IEA spindle IEA midbody IDA nuclear chromosome IDA cytosol IDA interphase microtubule organizing center IDA chromosome passenger complex IPI cytoplasm IDA condensed chromosome kinetochore IDA spindle microtubule IDA chromosome, pericentric region IDA mitotic prometaphase TAS negative regulation of apoptosis IDA positive regulation of cell proliferation TAS spindle checkpoint IMP protein complex localization IMP positive regulation of exit from mitosis IMP apoptosis IEA regulation of apoptosis IMP transcription, DNA-dependent IEA establishment of chromosome localization IMP cytokinesis IMP positive regulation of progression through mitotic cell cycle IMP mitosis TAS chromosome segregation IEA G2/M transition of mitotic cell cycle IDA protein amino acid phosphorylation IDA negative regulation of transcription, DNA-dependent IMP cell division IEA microtubule binding IDA cofactor binding IDA cysteine protease inhibitor activity IEA protein heterodimerization activity IDA zinc ion binding IDA protein homodimerization activity IDA caspase inhibitor activity IMP metal ion binding IEA cobalt ion binding NAS Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor 4; Apoptosis inhibitor survivin 10626797 10876248 10949039 11069302 11084331 12773388 14610074 14702039 14741722 15249581 15489334 15665297 16239925 16291752 16322459 16329164 16344111 16427043 16436504 16625196 16762323 16764853 17956729 17993464 18329369 18591255 18691976 19530738 20826784 21225229 21252625 21536684 9256286 9859993 NA BIRC5 1 Baculoviral IAP repeat-containing protein 5 Apoptosis inhibitor 4 Apoptosis inhibitor survivin gene 1291 5.59962278657706E-4 GPR89A C - Cellular Fate and Organization Golgi-associated vesicle membrane IDA integral to membrane IEA protein transport IEA positive regulation of I-kappaB kinase/NF-kappaB cascade IMP cellular pH reduction IDA signal transducer activity IMP voltage-gated ion-selective channel activity IDA Golgi pH regulator A; Protein GPR89A; Putative MAPK-activating protein PM01; Putative NF-kappa-B-activating protein 90 10810093 12761501 12975309 14702039 15489334 16710414 18794847 19135895 NA GPHRA 1 Golgi pH regulator A Protein GPR89A Putative MAPK-activating protein PM01 Putative NF-kappa-B-activating protein 90 gene 1291 1.61614024993302E-4 RPGR D - Genome Maintenance centrosome IDA Golgi apparatus ISS cilium axoneme IEA photoreceptor outer segment IDA cilium biogenesis IMP intraflagellar transport ISS intracellular protein transport TAS visual perception IMP response to stimulus IEA guanyl-nucleotide exchange factor activity IEA X-linked retinitis pigmentosa GTPase regulator; Precursor 10401007 10480356 10482958 10737996 10932196 10937588 10958648 10970770 10980543 11180598 11702207 11857109 11992260 12140192 12160730 12657579 12920075 14564670 14627685 15489334 15772089 15772651 16043481 19430481 21933838 8673101 8817343 9399904 9855162 9990021 NA RPGR -1 X-linked retinitis pigmentosa GTPase regulator Precursor gene 1291 0.00375315258666234 NISCH C - Cellular Fate and Organization plasma membrane IDA early endosome IEA cytosol IDA Rac protein signal transduction IEA negative regulation of cell migration IEA actin cytoskeleton organization and biogenesis IEA regulation of synaptic transmission, GABAergic IEA blood pressure regulation IEA glucose metabolic process IEA apoptosis IEA norepinephrine secretion IEA phosphoinositide binding IEA amine receptor activity IEA Nischarin; Imidazoline receptor 1; I-1; IR1; Imidazoline receptor antisera-selected protein; hIRAS; Imidazoline-1 receptor; I1R; Imidazoline-1 receptor candidate protein; I-1 receptor candidate protein; I1R candidate protein 10231032 10882231 11912194 12868002 14702039 15028619 15028621 15475348 15489334 16641997 17974005 19690332 21269460 9851558 NA NISCH -1 Nischarin Imidazoline receptor 1 I-1 IR1 Imidazoline receptor antisera-selected protein hIRAS Imidazoline-1 receptor I1R Imidazoline-1 receptor candidate protein I-1 receptor candidate protein I1R candidate protein gene 1291 0.0461415698267577 C - Cellular Fate and Organization transport vesicle IEA Golgi apparatus IEA caveola IDA nucleus IEA cell projection IEA cytoskeleton IEA lysosome IDA focal adhesion IMP cytosol TAS extrinsic to internal side of plasma membrane IMP phagocytosis IEA negative regulation of apoptosis IMP positive regulation of cell proliferation IMP leukocyte migration during immune response TAS regulation of cell shape IMP regulation of inflammatory response TAS respiratory burst after phagocytosis TAS peptidyl-tyrosine phosphorylation IMP leukocyte degranulation TAS regulation of antiviral response by virus TAS regulation of phagocytosis IMP regulation of transcription factor activity IMP inflammatory response IEA innate immune response-activating signal transduction TAS protein amino acid autophosphorylation IMP positive regulation of actin filament polymerization TAS integrin-mediated signaling pathway TAS virus-host interaction IEA viral reproduction TAS mesoderm development TAS cell adhesion TAS lipopolysaccharide-mediated signaling pathway TAS protein-tyrosine kinase activity IMP non-membrane spanning protein tyrosine kinase activity IEA ATP binding IEA Tyrosine-protein kinase HCK; 2.7.10.2; Hematopoietic cell kinase; Hemopoietic cell kinase; p59-HCK/p60-HCK; p59Hck; p61Hck 10092522 10360180 10644735 10779760 10973280 11278465 11518702 11741929 11780052 11896602 11904303 12411494 14702039 15010462 15489334 1572549 15952790 15998323 16216497 16849330 16997556 17141806 17310994 17344846 17535448 18538446 1875927 19114024 19369195 19718658 19807924 19903482 20452982 20810664 21338576 21477083 21625496 3453117 3496523 7535819 7791757 8064233 8132624 8995234 9024658 9109402 9218412 9406996 9407116 9571048 9778343 NA HCK -1 Tyrosine-protein kinase HCK 2.7.10.2 Hematopoietic cell kinase Hemopoietic cell kinase p59-HCK/p60-HCK p59Hck p61Hck gene 1291 0.0278647230913388 PPP1CA D - Genome Maintenance glycogen granule IEA dendritic spine IEA protein phosphatase type 1 complex IEA nucleolus IEA perikaryon IEA cytosol TAS regulation of glycogen biosynthetic process IEA cell cycle IEA protein amino acid dephosphorylation TAS lung development IEA glycogen metabolic process IEA transforming growth factor beta receptor signaling pathway TAS triacylglycerol catabolic process TAS branching morphogenesis of a tube IEA negative regulation of transforming growth factor beta receptor signaling pathway TAS regulation of glycogen catabolic process IEA cell division IEA ribonucleoprotein binding IEA protein serine/threonine phosphatase activity TAS metal ion binding IEA Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; PP-1A; 3.1.3.16 11564868 11739654 11839776 12226088 14702039 15489334 15705855 16263087 16554811 16732323 17283141 17626005 17890166 17965019 18088087 18669648 18992256 19377461 19581931 20068231 20305656 20424263 20516061 21269460 2161401 8384581 8392016 9023344 NA PP1A 1 Serine/threonine-protein phosphatase PP1-alpha catalytic subunit PP-1A 3.1.3.16 gene 1291 0.00551430130139407 EML1 C - Cellular Fate and Organization cytoplasm IEA microtubule associated complex TAS microtubule IEA calcium ion binding NAS Echinoderm microtubule-associated protein-like 1; EMAP-1; HuEMAP-1 10521658 15489334 9226380 NA EMAL1 -1 Echinoderm microtubule-associated protein-like 1 EMAP-1 HuEMAP-1 gene 1291 0.239033995593941 C - Cellular Fate and Organization cytoplasm IDA integral to plasma membrane TAS nucleus IDA immune response TAS positive regulation of cell proliferation TAS muscle contraction TAS G-protein signaling, coupled to cyclic nucleotide second messenger TAS digestion TAS synaptic transmission TAS vasoactive intestinal polypeptide receptor activity TAS Vasoactive intestinal polypeptide receptor 1; VIP-R-1; Pituitary adenylate cyclase-activating polypeptide type II receptor; PACAP type II receptor; PACAP-R-2; PACAP-R2; VPAC1; Precursor 14702039 14734527 15489334 16641997 18650441 7818527 7917790 8179610 8390245 8926282 9928020 NA VIPR1 -1 Vasoactive intestinal polypeptide receptor 1 VIP-R-1 Pituitary adenylate cyclase-activating polypeptide type II receptor PACAP type II receptor PACAP-R-2 PACAP-R2 VPAC1 Precursor gene 1291 0.274618126864437 LGI3 A - Transport and Sensing neuron projection IEA cell junction IEA extracellular region IEA synaptic vesicle IEA regulation of exocytosis IEA exocytosis IEA Leucine-rich repeat LGI family member 3; LGI1-like protein 4; Leucine-rich glioma-inactivated protein 3; Precursor 12023020 12095917 12217514 12975309 14702039 15489334 NA LGI3 -1 Leucine-rich repeat LGI family member 3 LGI1-like protein 4 Leucine-rich glioma-inactivated protein 3 Precursor gene 1309 1.0 FOXD3 D - Genome Maintenance transcription factor complex IBA nuclear chromatin IDA pattern specification process IBA ureteric bud branching IBA kidney development IBA cartilage development IBA neural crest cell migration IBA embryonic placenta development IBA melanocyte differentiation IBA axon extension involved in axon guidance IBA trophectodermal cell differentiation IBA sympathetic nervous system development IBA enteric nervous system development IBA regulation of transcription factor activity IBA positive regulation of transcription from RNA polymerase II promoter IDA iridophore differentiation IBA peripheral nervous system development IBA lateral line nerve glial cell development IBA double-stranded DNA binding IBA DNA bending activity IBA RNA polymerase II transcription factor activity, enhancer binding IBA transcription factor binding IBA Forkhead box protein D3; HNF3/FH transcription factor genesis 11891324 16098053 16710414 8499623 NA FOXD3 0 Forkhead box protein D3 HNF3/FH transcription factor genesis TF 1291 0.0134562520322556 PTGER4 C - Cellular Fate and Organization plasma membrane TAS integral to membrane NAS T-helper cell differentiation ISS regulation of ossification IEA negative regulation of inflammatory response IDA positive regulation of inflammatory response ISS JNK cascade ISS response to lipopolysaccharide IEA regulation of stress fiber formation ISS G-protein signaling, coupled to cAMP nucleotide second messenger IDA positive regulation of cytokine secretion ISS negative regulation of cytokine secretion ISS prostaglandin E receptor activity IDA Prostaglandin E2 receptor EP4 subtype; PGE receptor EP4 subtype; PGE2 receptor EP4 subtype; Prostanoid EP4 receptor 11597569 14709160 15489334 16424369 8163486 8250933 8661119 8862514 NA PE2R4 -1 Prostaglandin E2 receptor EP4 subtype PGE receptor EP4 subtype PGE2 receptor EP4 subtype Prostanoid EP4 receptor gene 1291 0.00192483829616325 PLSCR4 N - Not Matched plasma membrane IDA integral to membrane NAS phospholipid scrambling NAS blood coagulation NAS phospholipid scramblase activity NAS calcium ion binding NAS Phospholipid scramblase 4; PL scramblase 4; Ca(2+)-dependent phospholipid scramblase 4; Cell growth-inhibiting gene 43 protein; TRA1 10930526 14702039 15489334 16641997 17974005 18256029 23089641 NA PLS4 -1 Phospholipid scramblase 4 PL scramblase 4 Ca(2+)-dependent phospholipid scramblase 4 Cell growth-inhibiting gene 43 protein TRA1 gene 1291 0.0174922913889037 D - Genome Maintenance cytoplasm IEA cell cycle IEA Programmed cell death protein 2-like 15057824 15489334 17393540 21269460 NA PDD2L 1 Programmed cell death protein 2-like gene 1291 0.178836329879221 D - Genome Maintenance centrosome IDA nucleus TAS cytosol TAS antigen processing and presentation of exogenous peptide antigen via MHC class II TAS Dynactin subunit 4; Dyn4; Dynactin subunit p62 10671518 14702039 15372022 15489334 16554302 21269460 NA DCTN4 1 Dynactin subunit 4 Dyn4 Dynactin subunit p62 gene 1291 0.0483359921870727 KIAA0101 D - Genome Maintenance perinuclear region IDA nucleus IDA DNA replication IDA centrosome organization and biogenesis IMP regulation of cell cycle IMP response to UV IDA bypass DNA synthesis IMP chromatin binding IDA PCNA-associated factor; Hepatitis C virus NS5A-transactivated protein 9; HCV NS5A-transactivated protein 9; Overexpressed in anaplastic thyroid carcinoma 1; OEATC-1; PCNA-associated factor of 15 kDa; PAF15; p15PAF 11313979 14702039 15334068 15489334 15789362 16288740 16572171 18669648 19219066 20068231 21269460 21628590 21673012 21700221 22096502 23000965 7788527 NA PAF15 1 PCNA-associated factor Hepatitis C virus NS5A-transactivated protein 9 HCV NS5A-transactivated protein 9 Overexpressed in anaplastic thyroid carcinoma 1 OEATC-1 PCNA-associated factor of 15 kDa PAF15 p15PAF gene 1291 0.0313018543002082 C20orf24 Uncharacterized protein C20orf24; Rab5-interacting protein; RIP5 11780052 14759258 15489334 8824393 NA CT024 1 Uncharacterized protein C20orf24 Rab5-interacting protein RIP5 gene 1291 0.020077089894473 FAM13B C - Cellular Fate and Organization cytosol TAS positive regulation of GTPase activity IEA regulation of small GTPase mediated signal transduction TAS small GTPase mediated signal transduction TAS GTPase activator activity IEA Protein FAM13B; GAP-like protein N61 10931946 11087669 15372022 15489334 NA FA13B -1 Protein FAM13B GAP-like protein N61 gene 36061 0.13928531290922 reported 1 mir 1291 0.00675092610057069 N - Not Matched intracellular IDA Protein FAM49A 11230166 15489334 NA FA49A -1 Protein FAM49A gene 8158 0.114807089336956 novel 1 mir 1291 0.283263917962596 DENND3 C - Cellular Fate and Organization endosome to lysosome transport ISS cellular protein catabolic process ISS Rab guanyl-nucleotide exchange factor activity IDA DENN domain-containing protein 3 10048485 14702039 15489334 16421571 20937701 NA DEND3 -1 DENN domain-containing protein 3 gene 1291 0.0783685434449873 STIL D - Genome Maintenance centrosome IDA cytosol IEA heart looping ISS negative regulation of apoptosis ISS embryonic axis specification ISS body growth ISS cell proliferation TAS neural tube closure ISS forebrain development ISS notochord development ISS embryonic development (sensu Mammalia) ISS smoothened signaling pathway ISS SCL-interrupting locus protein; TAL-1-interrupting locus protein 11390401 12438740 12681356 1311214 14504110 15107824 15489334 16024801 16710414 17974005 18669648 19215732 1922059 19690332 2209547 2255914 9372240 NA STIL 1 SCL-interrupting locus protein TAL-1-interrupting locus protein gene 1291 0.0218918562607483 PNPLA6 N - Not Matched endoplasmic reticulum membrane IEA integral to membrane IEA lipid catabolic process IEA cell death IEA phosphatidylcholine metabolic process IEA lysophospholipase activity IEA Neuropathy target esterase; 3.1.1.5; Patatin-like phospholipase domain-containing protein 6 14702039 15044461 15057824 15489334 1666291 17974005 18313024 18669648 18691976 20068231 21269460 9576844 NA PLPL6 -1 Neuropathy target esterase 3.1.1.5 Patatin-like phospholipase domain-containing protein 6 gene 1291 0.0161084217716039 CALCRL C - Cellular Fate and Organization endoplasmic reticulum IDA integral to plasma membrane TAS lysosome IDA endosome IDA heart development IEA receptor internalization IDA regulation of muscle contraction IEA G-protein signaling, coupled to cyclic nucleotide second messenger TAS negative regulation of inflammatory response IEA positive regulation of cAMP biosynthetic process IDA cAMP biosynthetic process IDA calcium ion transport IDA angiogenesis IDA G-protein signaling, adenylate cyclase activating pathway IEA positive regulation of smooth muscle cell proliferation IEA calcitonin receptor activity IEA adrenomedullin receptor activity IDA protein transporter activity IDA calcitonin gene-related polypeptide receptor activity IEA Calcitonin gene-related peptide type 1 receptor; CGRP type 1 receptor; Calcitonin receptor-like receptor; Precursor 14702039 15340161 15815621 20826335 22102369 7818539 8626685 NA CALRL -1 Calcitonin gene-related peptide type 1 receptor CGRP type 1 receptor Calcitonin receptor-like receptor Precursor gene 1291 0.00252767224368014 T - Transcription cytoplasm IEA synapse IEA nucleus IEA dendrite IEA positive regulation of membrane potential IEA regulation of transcription, DNA-dependent IEA protein sumoylation ISS response to hormone stimulus IEA transcription, DNA-dependent IEA SUMO ligase activity IEA potassium channel regulator activity IEA zinc ion binding IEA nucleic acid binding IEA E3 SUMO-protein ligase PIAS3; 6.3.2.-; Protein inhibitor of activated STAT protein 3 10319586 11060035 11071847 14715251 15208321 15489334 17974005 9388184 NA PIAS3 1 E3 SUMO-protein ligase PIAS3 6.3.2.- Protein inhibitor of activated STAT protein 3 gene 1291 0.430071674356879 SOCS2 C - Cellular Fate and Organization cytosol TAS negative regulation of apoptosis TAS protein ubiquitination IEA aging IEA negative regulation of signal transduction IEA regulation of cell growth NAS response to estradiol stimulus IDA JAK pathway signal transduction adaptor activity TAS prolactin receptor binding NAS SH3/SH2 adaptor activity TAS growth hormone receptor binding NAS Suppressor of cytokine signaling 2; SOCS-2; Cytokine-inducible SH2 protein 2; CIS-2; STAT-induced STAT inhibitor 2; SSI-2 10512686 14702039 15489334 16675548 21269460 9266833 9344848 9727029 NA SOCS2 -1 Suppressor of cytokine signaling 2 SOCS-2 Cytokine-inducible SH2 protein 2 CIS-2 STAT-induced STAT inhibitor 2 SSI-2 gene 1291 0.106951875741358 SLC39A8 A - Transport and Sensing plasma membrane TAS organelle membrane IDA integral to membrane IEA zinc ion transport IMP metal ion transporter activity IEA Zinc transporter ZIP8; BCG-induced integral membrane protein in monocyte clone 103 protein; LIV-1 subfamily of ZIP zinc transporter 6; LZT-Hs6; Solute carrier family 39 member 8; Zrt- and Irt-like protein 8; ZIP-8 12504855 14702039 15489334 15498874 15815621 NA S39A8 -1 Zinc transporter ZIP8 BCG-induced integral membrane protein in monocyte clone 103 protein LIV-1 subfamily of ZIP zinc transporter 6 LZT-Hs6 Solute carrier family 39 member 8 Zrt- and Irt-like protein 8 ZIP-8 gene 2871 2.82934548495022E-4 known 1 mir 1291 1.04725998408334E-6 STARD9 M - Other Metabolism centriole IDA microtubule associated complex IEA nucleus IDA spindle assembly IMP microtubule-based movement IEA microtubule binding IDA microtubule motor activity IDA ATP binding IEA StAR-related lipid transfer protein 9; START domain-containing protein 9; StARD9 10718198 14702039 16572171 16964419 17974005 22153075 22453275 NA STAR9 -1 StAR-related lipid transfer protein 9 START domain-containing protein 9 StARD9 gene 1291 0.00655360402115204 STARD8 C - Cellular Fate and Organization focal adhesion IEA cytosol TAS positive regulation of GTPase activity IEA regulation of small GTPase mediated signal transduction TAS small GTPase mediated signal transduction TAS GTPase activator activity IEA StAR-related lipid transfer protein 8; Deleted in liver cancer 3 protein; DLC-3; START domain-containing protein 8; StARD8; START-GAP3 14702039 15489334 15772651 16959974 17297465 17517630 17974005 17976533 8724849 NA STAR8 -1 StAR-related lipid transfer protein 8 Deleted in liver cancer 3 protein DLC-3 START domain-containing protein 8 StARD8 START-GAP3 gene 1291 0.356792102018483 STARD7 N - Not Matched mitochondrion IEA StAR-related lipid transfer protein 7, mitochondrial; Gestational trophoblastic tumor protein 1; START domain-containing protein 7; StARD7; Precursor 15013637 15489334 15815621 21269460 NA STAR7 -1 StAR-related lipid transfer protein 7, mitochondrial Gestational trophoblastic tumor protein 1 START domain-containing protein 7 StARD7 Precursor gene 1291 0.0783685434449873 PAN2 T - Transcription cytoplasmic mRNA processing body IEA nucleus IEA cytosol TAS ubiquitin-dependent protein catabolic process IEA mRNA catabolic process, nonsense-mediated decay IEA poly(A) tail shortening TAS poly(A)-specific ribonuclease activity TAS ubiquitin thiolesterase activity IEA nucleic acid binding IEA PAB-dependent poly(A)-specific ribonuclease subunit 2; hPan2; 3.1.13.4; Inactive ubiquitin carboxyl-terminal hydrolase 52 14583602 14715245 15489334 16284618 16959974 16964243 18669648 21269460 9734811 NA PAN2 1 PAB-dependent poly(A)-specific ribonuclease subunit 2 hPan2 3.1.13.4 Inactive ubiquitin carboxyl-terminal hydrolase 52 gene 1291 4.69519573603869E-5 HSD17B6 M - Other Metabolism intracellular NAS endoplasmic reticulum IEA early endosome membrane IEA androgen biosynthetic process NAS androgen catabolic process TAS estradiol 17-beta-dehydrogenase activity IEA nucleotide binding IEA 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity IEA oxidoreductase activity NAS electron carrier activity TAS retinol dehydrogenase activity IEA 17-beta-hydroxysteroid dehydrogenase type 6; 17-beta-HSD 6; 17-beta-HSD6; 1.1.1.105; 1.1.1.239; 1.1.1.62; 3-alpha->beta-hydroxysteroid epimerase; 3-alpha->beta-HSE; Oxidative 3-alpha hydroxysteroid dehydrogenase; Precursor 10896656 11360992 11513953 15489334 9188497 NA H17B6 -1 17-beta-hydroxysteroid dehydrogenase type 6 17-beta-HSD 6 17-beta-HSD6 1.1.1.105 1.1.1.239 1.1.1.62 3-alpha->beta-hydroxysteroid epimerase 3-alpha->beta-HSE Oxidative 3-alpha hydroxysteroid dehydrogenase Precursor gene 1418 0.152810214692298 TYROBP A - Transport and Sensing integral to plasma membrane TAS cellular defense response TAS macrophage activation during immune response IEA integrin-mediated signaling pathway IEA axon guidance TAS regulation of immune response TAS neutrophil activation during immune response IEA receptor signaling protein activity TAS TYRO protein tyrosine kinase-binding protein; DNAX-activation protein 12; Killer-activating receptor-associated protein; KAR-associated protein; Precursor 10449773 10799849 10888890 11922939 12370476 14702039 15057824 15489334 15557162 16344560 16920917 17012248 17928527 19369195 20890284 9490415 NA TYOBP -1 TYRO protein tyrosine kinase-binding protein DNAX-activation protein 12 Killer-activating receptor-associated protein KAR-associated protein Precursor gene 1291 3.95044798301106E-4 HDLBP A - Transport and Sensing cytoplasm IDA plasma membrane TAS nucleus IEA lipid transport IEA cholesterol metabolic process TAS RNA binding IEA lipid binding TAS Vigilin; High density lipoprotein-binding protein; HDL-binding protein 1318310 14702039 15489334 15592455 15815621 16959974 18669648 19369195 19690332 20068231 21269460 21406692 8605996 NA VIGLN 1 Vigilin High density lipoprotein-binding protein HDL-binding protein gene 1291 0.0816080920104172 FBXL5 F - Protein Fate perinuclear region IDA SCF ubiquitin ligase complex IDA SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA ubiquitin-protein ligase activity NAS iron ion binding IDA F-box/LRR-repeat protein 5; F-box and leucine-rich repeat protein 5; F-box protein FBL4/FBL5; p45SKP2-like protein 10531035 10531037 10945468 14702039 15489334 15815621 17532294 17974005 19762596 19762597 22253436 22492618 NA FBXL5 -1 F-box/LRR-repeat protein 5 F-box and leucine-rich repeat protein 5 F-box protein FBL4/FBL5 p45SKP2-like protein gene 1291 0.14228945765784 GOLPH3L N - Not Matched lipid binding IEA Golgi phosphoprotein 3-like; GPP34-related protein 11042173 14702039 15489334 16710414 21269460 NA GLP3L 1 Golgi phosphoprotein 3-like GPP34-related protein gene 1291 0.0425429100466392 PTRF T - Transcription mitochondrion IDA endoplasmic reticulum IEA caveola IDA nucleoplasm TAS cytosol IEA regulation of transcription, DNA-dependent IEA transcription termination from RNA polymerase I promoter IDA transcription initiation from RNA polymerase I promoter IDA rRNA primary transcript binding IDA Polymerase I and transcript release factor; Cavin-1 14702039 15242332 15489334 16959974 17026959 17081983 18056712 18191225 18220336 18669648 18691976 19726876 20068231 20684003 21269460 21406692 9582279 NA PTRF -1 Polymerase I and transcript release factor Cavin-1 gene 1291 0.030922008657682 DEPP N - Not Matched mitochondrion IDA Protein DEPP; Decidual protein induced by progesterone; Fasting-induced gene protein; FIG 11230166 14702039 15164054 15489334 16123073 NA DEPP -1 Protein DEPP Decidual protein induced by progesterone Fasting-induced gene protein FIG gene 1291 2.64329064146711E-4 GREM1 C - Cellular Fate and Organization cell surface IEA extracellular space NAS positive regulation of NF-kappaB import into nucleus IEA ureteric bud branching IEA positive regulation of cell proliferation IDA negative regulation of cell growth IEA cell migration during sprouting angiogenesis ISS cell-cell signaling IEA apoptosis IEA proximal/distal pattern formation IEA embryonic limb morphogenesis IEA regulation of focal adhesion formation IEA positive regulation of angiogenesis IEA positive regulation of telomerase activity IDA negative regulation of BMP signaling pathway IMP cell morphogenesis IDA negative regulation of bone remodeling IMP activation of NF-kappaB transcription factor IEA collagen fibril organization IMP determination of dorsal identity IMP negative regulation of transcription, DNA-dependent IEA positive regulation of receptor internalization ISS morphogen activity ISS protein tyrosine kinase activator activity IEA vascular endothelial growth factor receptor 2 binding ISS receptor agonist activity ISS Gremlin-1; Cell proliferation-inducing gene 2 protein; Cysteine knot superfamily 1, BMP antagonist 1; DAN domain family member 2; Down-regulated in Mos-transformed cells protein; Increased in high glucose protein 2; IHG-2; Precursor 10744662 10894942 14702039 15340161 15489334 22561515 9660951 NA GREM1 1 Gremlin-1 Cell proliferation-inducing gene 2 protein Cysteine knot superfamily 1, BMP antagonist 1 DAN domain family member 2 Down-regulated in Mos-transformed cells protein Increased in high glucose protein 2 IHG-2 Precursor gene 1291 0.050860863154566 TNFAIP3 D - Genome Maintenance centrosome IDA nucleus IDA lysosome IEA cytosol TAS negative regulation of interleukin-2 production IMP positive regulation of protein catabolic process IDA negative regulation of B cell activation ISS negative regulation of interleukin-6 production ISS negative regulation of cyclin-dependent protein kinase activity IEA negative regulation of interleukin-1 beta production IEA negative regulation of tumor necrosis factor-alpha production ISS negative regulation of smooth muscle cell proliferation IDA inhibition of NF-kappaB transcription factor IDA protein oligomerization NAS regulation of antiviral response by host NAS negative regulation of bone resorption NAS inflammatory response IEA negative regulation of chronic inflammatory response IEA innate immune response TAS negative regulation of inflammatory response ISS proteolysis IEA response to muramyl dipeptide IEA negative regulation of protein ubiquitination IDA B-1 B cell homeostasis ISS negative regulation of interferon type I production TAS regulation of germinal center formation ISS negative regulation of I-kappaB kinase/NF-kappaB cascade IDA ubiquitin-protein ligase activity IDA ubiquitin-specific protease activity IDA zinc ion binding IEA ubiquitin thiolesterase activity IMP protein self-association IDA DNA binding IEA caspase inhibitor activity NAS Tumor necrosis factor alpha-induced protein 3; TNF alpha-induced protein 3; 3.4.19.12; 6.3.2.-; OTU domain-containing protein 7C; Putative DNA-binding protein A20; Zinc finger protein A20; A20p50; A20p37 10435631 11463333 14574404 14702039 14748687 15258597 15489334 16684768 17081983 17961127 17974005 18164316 18223652 18669648 18952128 19131965 19494296 19690332 20804738 21095585 2118515 22099304 8692885 9299557 9882303 NA TNAP3 -1 Tumor necrosis factor alpha-induced protein 3 TNF alpha-induced protein 3 3.4.19.12 6.3.2.- OTU domain-containing protein 7C Putative DNA-binding protein A20 Zinc finger protein A20 A20p50 A20p37 gene 1291 1.0 FOXA2 D - Genome Maintenance transcription factor complex IBA cytoplasm IEA cell differentiation in hindbrain IBA adult locomotory behavior IEA ectoderm formation IBA neuron fate specification IBA myelin formation in the central nervous system IBA embryonic development (sensu Mammalia) IBA negative regulation of transcription factor activity IMP regulation of blood coagulation IDA endoderm development IBA negative regulation of neuron differentiation IBA positive regulation of neuron differentiation IBA endocrine pancreas development IDA positive regulation of transcription from RNA polymerase III promoter IEA positive regulation of embryonic development ISS negative regulation of transcription from RNA polymerase II promoter by glucose ISS positive regulation of transcription from RNA polymerase II promoter by glucose ISS dorsoventral neural tube patterning IBA oligodendrocyte cell fate commitment IBA chromatin modification IEA double-stranded DNA binding IBA DNA bending activity IBA RNA polymerase II transcription factor activity, enhancer binding IBA protein domain specific binding IBA transcription factor binding IBA Hepatocyte nuclear factor 3-beta; HNF-3-beta; HNF-3B; Forkhead box protein A2; Transcription factor 3B; TCF-3B 10672453 10899756 11780052 14500912 15489334 15737987 19478084 19919681 NA FOXA2 0 Hepatocyte nuclear factor 3-beta HNF-3-beta HNF-3B Forkhead box protein A2 Transcription factor 3B TCF-3B TF 1291 0.0308405787803432 TNFAIP1 D - Genome Maintenance Cul3-RING ubiquitin ligase complex IDA nucleus IDA endosome IDA DNA replication ISS immune response IEP protein ubiquitination IDA cell migration IMP negative regulation of Rho protein signal transduction IMP stress fiber formation IMP positive regulation of DNA replication IEA apoptosis TAS proteasomal ubiquitin-dependent protein catabolic process IDA protein homooligomerization IEA embryonic development ISS GTP-Rho binding IDA BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; hBACURD2; BTB/POZ domain-containing protein TNFAIP1; Protein B12; Tumor necrosis factor, alpha-induced protein 1, endothelial 1370465 14702039 15489334 16625196 18669648 19637314 19782033 19851886 20068231 NA BACD2 -1 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 hBACURD2 BTB/POZ domain-containing protein TNFAIP1 Protein B12 Tumor necrosis factor, alpha-induced protein 1, endothelial gene 1291 0.0617829085001869 TSPAN5 N - Not Matched integral to membrane IEA Tetraspanin-5; Tspan-5; Tetraspan NET-4; Transmembrane 4 superfamily member 9 14702039 15489334 9714763 NA TSN5 1 Tetraspanin-5 Tspan-5 Tetraspan NET-4 Transmembrane 4 superfamily member 9 gene 1291 0.0882021116002911 NONO D - Genome Maintenance paraspeckles IDA nuclear speck IEA nucleolus IEA nuclear matrix IDA mRNA processing TAS RNA splicing TAS regulation of transcription, DNA-dependent IEA DNA repair IEA DNA recombination IEA transcription, DNA-dependent IEA nucleotide binding IEA RNA binding IEA nucleic acid binding IEA DNA binding IEA Non-POU domain-containing octamer-binding protein; NonO protein; 54 kDa nuclear RNA- and DNA-binding protein; 55 kDa nuclear protein; DNA-binding p52/p100 complex, 52 kDa subunit; NMT55; p54(nrb); p54nrb 10858305 11525732 11897684 12403470 14702039 15489334 15590677 15772651 16148043 16964243 17081983 17693683 17924679 18220336 18655028 18669648 18691976 19608861 19690332 20068231 21269460 21406692 22002106 22416126 8371983 8439294 9341872 9360842 9393982 9756848 NA NONO 1 Non-POU domain-containing octamer-binding protein NonO protein 54 kDa nuclear RNA- and DNA-binding protein 55 kDa nuclear protein DNA-binding p52/p100 complex, 52 kDa subunit NMT55 p54(nrb) p54nrb gene 1475 0.142229022828119 N - Not Matched plasma membrane IEA integral to membrane IEA extrinsic to membrane IEA Synaptotagmin-15; Chr10Syt; Synaptotagmin XV; SytXV 11543631 12788067 14702039 15164054 15489334 NA SYT15 -1 Synaptotagmin-15 Chr10Syt Synaptotagmin XV SytXV gene 3696 1.0 C - Cellular Fate and Organization transcription factor complex IEA nuclear euchromatin IDA nucleoplasm TAS regulation of cell size IEA nerve growth factor receptor signaling pathway TAS response to drug IEA phosphoinositide-mediated signaling TAS pituitary gland development IEA protein stabilization ISS synaptic transmission TAS phospholipase C activation TAS stress-activated MAPK cascade TAS positive regulation of lipid biosynthetic process ISS Toll signaling pathway TAS lactation IEA epidermal growth factor receptor signaling pathway TAS axon guidance TAS fibroblast growth factor receptor signaling pathway TAS innate immune response TAS MyD88-dependent toll-like receptor signaling pathway TAS virus-host interaction IEA positive regulation of hormone secretion IEA positive regulation of fat cell differentiation ISS protein amino acid phosphorylation IDA positive regulation of body size IEA transcription cofactor activity TAS RNA polymerase II transcription factor activity, enhancer binding IDA Cyclic AMP-responsive element-binding protein 1; CREB-1; cAMP-responsive element-binding protein 1 12552083 1386673 14506290 14536081 15454081 15489334 15579595 15733869 16325578 16908542 17525332 17724745 1827531 1831258 18669648 1966745 19690332 20573984 21172805 21406692 2142528 2196176 22267179 2974179 7608156 8065343 8381074 9770464 9829964 NA CREB1 0 Cyclic AMP-responsive element-binding protein 1 CREB-1 cAMP-responsive element-binding protein 1 TF 1508 8.00935275700312E-5 A - Transport and Sensing cell junction IEA synaptic vesicle membrane IEA integral to membrane IEA Synaptotagmin-12; Synaptotagmin XII; SytXII 15489334 NA SYT12 1 Synaptotagmin-12 Synaptotagmin XII SytXII gene 1291 0.0021046852814931 MMP11 F - Protein Fate Golgi lumen TAS extracellular matrix (sensu Metazoa) TAS extracellular matrix disassembly TAS collagen catabolic process IEA proteolysis TAS multicellular organismal development TAS calcium ion binding IEA zinc ion binding IEA metalloendopeptidase activity TAS Stromelysin-3; SL-3; ST3; 3.4.24.-; Matrix metalloproteinase-11; MMP-11; Precursor 10591208 15489334 16959974 1701851 7657606 7746327 NA MMP11 1 Stromelysin-3 SL-3 ST3 3.4.24.- Matrix metalloproteinase-11 MMP-11 Precursor gene 1291 0.00252767224368014 A - Transport and Sensing perinuclear region IEA clathrin-coated vesicle IEA nucleus IEA lipid binding IEA Epsin-3; EPS-15-interacting protein 3 11359770 14702039 15489334 NA EPN3 1 Epsin-3 EPS-15-interacting protein 3 gene 1291 0.0178778291877126 C - Cellular Fate and Organization mitochondrion TAS apoptosis TAS p53-regulated apoptosis-inducing protein 1; p53AIP1 11030628 15489334 16554811 NA TPIP1 -1 p53-regulated apoptosis-inducing protein 1 p53AIP1 gene 1291 0.117179770282665 SDHC E - Energy Production respiratory chain complex II (sensu Eukaryota) ISS integral to membrane TAS tricarboxylic acid cycle TAS succinate dehydrogenase activity IEA electron carrier activity IEA metal ion binding IEA heme binding ISS Succinate dehydrogenase cytochrome b560 subunit, mitochondrial; Integral membrane protein CII-3; QPs-1; QPs1; Succinate dehydrogenase complex subunit C; Succinate-ubiquinone oxidoreductase cytochrome B large subunit; CYBL; Precursor 11062460 14702039 15489334 16710414 17804857 21269460 9533030 9714607 9851882 NA C560 1 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial Integral membrane protein CII-3 QPs-1 QPs1 Succinate dehydrogenase complex subunit C Succinate-ubiquinone oxidoreductase cytochrome B large subunit CYBL Precursor gene 1291 0.0218918562607483 GRK5 C - Cellular Fate and Organization cytoplasm TAS plasma membrane IDA nucleus IEA negative regulation of apoptosis IDA regulation of G-protein coupled receptor protein signaling pathway TAS protein amino acid autophosphorylation IDA apoptosis IEA tachykinin signaling pathway IDA G-protein signaling, coupled to cAMP nucleotide second messenger TAS Wnt receptor signaling pathway IEA G-protein coupled receptor kinase activity IEA phospholipid binding TAS protein serine/threonine kinase activity IDA protein kinase C binding TAS ATP binding IEA G protein-coupled receptor kinase 5; 2.7.11.16; G protein-coupled receptor kinase GRK5 14976207 15164054 15489334 15542828 17344846 18425130 18669648 19661922 19801552 20038610 20124405 21728385 7685906 8144599 8381058 9218466 NA GRK5 -1 G protein-coupled receptor kinase 5 2.7.11.16 G protein-coupled receptor kinase GRK5 gene 1291 0.0958343609500199 Protein FAM46B 15489334 16710414 NA FA46B -1 Protein FAM46B gene 1291 0.0750711142623216 NCAPD3 D - Genome Maintenance nuclear condensin complex IDA nuclear centric heterochromatin IDA mitotic chromosome condensation IDA cell division IEA methylated histone residue binding IDA Condensin-2 complex subunit D3; Non-SMC condensin II complex subunit D3; hCAP-D3 14532007 15489334 16554811 17081983 18220336 18669648 18691976 19690332 20068231 21269460 21406692 7584044 NA CNDD3 1 Condensin-2 complex subunit D3 Non-SMC condensin II complex subunit D3 hCAP-D3 gene 1291 0.00616644798288088 H2AFV D - Genome Maintenance nucleus IEA nucleosome IEA nucleosome assembly IEA DNA binding IEA Histone H2A.V; H2A.F/Z 12853948 14702039 15489334 16457589 NA H2AV 1 Histone H2A.V H2A.F/Z gene 1291 0.00767110316326083 WAPAL D - Genome Maintenance cytoplasm IDA cohesin complex IDA synaptonemal complex IEA microtubule cytoskeleton IDA nucleus IDA chromatin IDA mitosis IEA virus-host interaction IEA response to toxin IEA negative regulation of DNA replication IMP negative regulation of sister chromatid cohesion IMP cell division IEA Wings apart-like protein homolog; Friend of EBNA2 protein 15150110 15164054 15383329 15489334 17081983 17112726 17113138 18669648 18691976 19369195 19608861 19690332 19696148 19907496 20068231 21111234 21269460 21406692 9039502 NA WAPL -1 Wings apart-like protein homolog Friend of EBNA2 protein gene 1291 0.0112763430619318 VMP1 C - Cellular Fate and Organization plasma membrane IEA endoplasmic reticulum IDA autophagic vacuole membrane ISS pre-autophagosomal structure IEA integral to membrane IEA cell-cell adhesion IMP embryo implantation IEA autophagy IEA Vacuole membrane protein 1; Transmembrane protein 49 11230166 15489334 17724469 19056683 NA VMP1 1 Vacuole membrane protein 1 Transmembrane protein 49 gene 62440 4.54614875271903E-6 novel 1 mir 1291 0.126666714321277 N - Not Matched nucleus IEA cytosol IDA virus-host interaction IEA protein homooligomerization IEA BTB/POZ domain-containing protein KCTD5 14702039 15489334 17239418 18573101 19361449 20068231 21269460 NA KCTD5 1 BTB/POZ domain-containing protein KCTD5 gene 1291 0.0461415698267577 TNXB C - Cellular Fate and Organization intracellular IDA extracellular matrix (sensu Metazoa) NAS extracellular space IDA signal transduction IEA cell-cell adhesion IEA actin cytoskeleton organization and biogenesis ISS cell-matrix adhesion IEA collagen fibril organization IEA fatty acid metabolic process IEA triacylglycerol metabolic process IEA regulation of JNK activity IEA fibril organization and biogenesis IEA cell adhesion ISS elastic fiber assembly IMP integrin binding ISS heparin binding ISS Tenascin-X; TN-X; Hexabrachion-like protein; Precursor 11642233 1373119 14574404 14656967 15489334 15733269 16335952 17033827 17263730 19159218 2475872 7686164 8530023 8923003 NA TENX -1 Tenascin-X TN-X Hexabrachion-like protein Precursor gene 2556 1.0 HNF4A C - Cellular Fate and Organization cytoplasm IDA nucleoplasm TAS lipid metabolic process IEA negative regulation of cell growth IMP negative regulation of cell proliferation IMP xenobiotic metabolic process IMP transcription initiation from RNA polymerase II promoter TAS glucose homeostasis ISS regulation of lipid metabolic process IDA response to glucose stimulus ISS regulation of insulin secretion ISS blood coagulation IDA endocrine pancreas development TAS sex differentiation IEA ornithine metabolic process IMP intracellular receptor-mediated signaling pathway IEA sequence-specific DNA binding IEA fatty acid binding IDA RNA polymerase II transcription factor activity, enhancer binding IEA receptor binding IDA steroid hormone receptor activity IEA zinc ion binding IEA ligand-dependent nuclear receptor activity IEA protein homodimerization activity IDA Hepatocyte nuclear factor 4-alpha; HNF-4-alpha; Nuclear receptor subfamily 2 group A member 1; Transcription factor 14; TCF-14; Transcription factor HNF-4 11780052 12740371 14982928 15489334 21708125 7568236 7926813 8622695 8945471 8964514 9243109 9267996 9313765 9449683 NA HNF4A 0 Hepatocyte nuclear factor 4-alpha HNF-4-alpha Nuclear receptor subfamily 2 group A member 1 Transcription factor 14 TCF-14 Transcription factor HNF-4 TF 1291 7.10291946619602E-4 USP12 F - Protein Fate ubiquitin-dependent protein catabolic process IEA protein deubiquitination IDA cysteine-type endopeptidase activity IMP ubiquitin-specific protease activity IDA ubiquitin thiolesterase activity IDA Ubiquitin carboxyl-terminal hydrolase 12; 3.4.19.12; Deubiquitinating enzyme 12; Ubiquitin thioesterase 12; Ubiquitin-hydrolyzing enzyme 1; Ubiquitin-specific-processing protease 12 14702039 15057823 15489334 19075014 9615226 NA UBP12 -1 Ubiquitin carboxyl-terminal hydrolase 12 3.4.19.12 Deubiquitinating enzyme 12 Ubiquitin thioesterase 12 Ubiquitin-hydrolyzing enzyme 1 Ubiquitin-specific-processing protease 12 gene 1291 1.0 RUNX2 C - Cellular Fate and Organization transcription factor complex IEA cytoplasm IEA nuclear chromatin ISS positive regulation of cell proliferation IEA transcription initiation from RNA polymerase II promoter TAS osteoblast fate commitment IEA negative regulation of smoothened signaling pathway IEA BMP signaling pathway ISS embryonic cranial skeleton morphogenesis IEA osteoblast differentiation IEP positive regulation of osteoblast differentiation IEA stem cell differentiation IEA endochondral ossification IEA T cell differentiation IEA osteoblast development IEA chondrocyte development IEA regulation of fibroblast growth factor receptor signaling pathway IEA odontogenesis (sensu Vertebrata) IEA cell maturation IEA positive regulation of chondrocyte differentiation IEA regulation of odontogenesis (sensu Vertebrata) IEA negative regulation of transcription, DNA-dependent IDA transcription factor activity NAS chromatin binding IEA ATP binding IEA Runt-related transcription factor 2; Acute myeloid leukemia 3 protein; Core-binding factor subunit alpha-1; CBF-alpha-1; Oncogene AML-3; Osteoblast-specific transcription factor 2; OSF-2; Polyomavirus enhancer-binding protein 2 alpha A subunit; PEA2-alpha A; PEBP2-alpha A; SL3-3 enhancer factor 1 alpha A subunit; SL3/AKV core-binding factor alpha A subunit 10521292 10545612 10689183 10980549 11857736 11965546 12081718 12145306 12196916 12424590 14574404 16270353 16407259 18220336 19744171 20082269 20648631 9182765 9207800 9233771 9434946 9651525 NA RUNX2 0 Runt-related transcription factor 2 Acute myeloid leukemia 3 protein Core-binding factor subunit alpha-1 CBF-alpha-1 Oncogene AML-3 Osteoblast-specific transcription factor 2 OSF-2 Polyomavirus enhancer-binding protein 2 alpha A subunit PEA2-alpha A PEBP2-alpha A SL3-3 enhancer factor 1 alpha A subunit SL3/AKV core-binding factor alpha A subunit TF 14540 1.0 RUNX1 C - Cellular Fate and Organization nucleus IDA basement membrane IEA regulation of signal transduction IEA central nervous system development IEA embryonic development (sensu Mammalia) IEA transcription, DNA-dependent IEA positive regulation of angiogenesis ISS hair follicle morphogenesis IEA liver development IEA skeletal development IEA positive regulation of transcription from RNA polymerase II promoter IDA positive regulation of granulocyte differentiation IMP peripheral nervous system neuron development TAS myeloid cell differentiation IDA negative regulation of granulocyte differentiation IMP myeloid progenitor cell differentiation IEA positive regulation of transcription, DNA-dependent IDA embryonic hemopoiesis IEA behavioral response to pain IEA transcription factor activity IDA protein heterodimerization activity IDA calcium ion binding IDA DNA binding IDA ATP binding NAS protein homodimerization activity IDA transcription factor binding IDA Runt-related transcription factor 1; Acute myeloid leukemia 1 protein; Core-binding factor subunit alpha-2; CBF-alpha-2; Oncogene AML-1; Polyomavirus enhancer-binding protein 2 alpha B subunit; PEA2-alpha B; PEBP2-alpha B; SL3-3 enhancer factor 1 alpha B subunit; SL3/AKV core-binding factor alpha B subunit 10207087 10404214 10508512 10545320 10830953 10856244 11276260 11742995 11965546 12217689 12377125 12917624 1423235 14970218 15489334 1560822 16652147 1720541 17431401 17532767 18280240 18669648 18695000 18925961 19608861 19690332 7533526 7541640 7651838 7761424 7780150 7795214 7835892 7891692 7919324 8313895 8334990 8353289 8395054 8413232 8490181 8634147 8700862 9119228 9199349 9596646 9751710 NA RUNX1 0 Runt-related transcription factor 1 Acute myeloid leukemia 1 protein Core-binding factor subunit alpha-2 CBF-alpha-2 Oncogene AML-1 Polyomavirus enhancer-binding protein 2 alpha B subunit PEA2-alpha B PEBP2-alpha B SL3-3 enhancer factor 1 alpha B subunit SL3/AKV core-binding factor alpha B subunit TF 1291 0.0080442634822031 Beta/gamma crystallin domain-containing protein 3 14702039 15489334 16641997 17974005 NA CRBG3 -1 Beta/gamma crystallin domain-containing protein 3 gene 1291 0.0212419471753895 AFF3 T - Transcription nucleolus IDA regulation of transcription, DNA-dependent IEA embryonic hindlimb morphogenesis IMP transcription, DNA-dependent IEA double-stranded DNA binding IDA AF4/FMR2 family member 3; Lymphoid nuclear protein related to AF4; Protein LAF-4 15489334 15815621 18669648 19369195 8555498 NA AFF3 -1 AF4/FMR2 family member 3 Lymphoid nuclear protein related to AF4 Protein LAF-4 gene 1291 0.0914604721306057 N - Not Matched lipid particle IDA perinuclear region IEA plasma membrane IEA endoplasmic reticulum membrane IEA integral to membrane TAS cytoskeleton IEA Cytoskeleton-associated protein 4; 63-kDa cytoskeleton-linking membrane protein; Climp-63; p63 15489334 15703217 16541075 17030514 17081983 17567679 18669648 19144824 20068231 21269460 8314870 NA CKAP4 1 Cytoskeleton-associated protein 4 63-kDa cytoskeleton-linking membrane protein Climp-63 p63 gene 1291 0.00691815401314746 CCSER2 Serine-rich coiled-coil domain-containing protein 2; Coiled-coil serine-rich protein 2; Protein GCAP14 homolog 10574461 14702039 15164054 15489334 NA CCSE2 -1 Serine-rich coiled-coil domain-containing protein 2 Coiled-coil serine-rich protein 2 Protein GCAP14 homolog gene 1291 0.107607101424208 CKAP2 D - Genome Maintenance cytoplasmic microtubule IDA spindle pole IEA centrosome IDA cytokinesis after mitosis IGI positive regulation of transcription from RNA polymerase II promoter IGI negative regulation of microtubule depolymerization IEA apoptosis IEA Cytoskeleton-associated protein 2; CTCL tumor antigen se20-10; Tumor- and microtubule-associated protein 11149944 11230166 11234418 12942315 14702039 15057823 15489334 17376772 17974005 18669648 19690332 20068231 21269460 9771967 NA CKAP2 1 Cytoskeleton-associated protein 2 CTCL tumor antigen se20-10 Tumor- and microtubule-associated protein gene 1291 0.0816561705194995 T - Transcription snRNP U7 IDA nucleoplasm TAS U12-dependent spliceosome IDA cytosol TAS spliceosome assembly NAS transcription termination from RNA polymerase II promoter TAS histone mRNA metabolic process TAS spliceosomal snRNP biogenesis TAS RNA binding IEA Small nuclear ribonucleoprotein E; snRNP-E; Sm protein E; Sm-E; SmE 11574479 11991638 14702039 15146077 15489334 21269460 2440864 2972723 2974536 NA RUXE 1 Small nuclear ribonucleoprotein E snRNP-E Sm protein E Sm-E SmE gene 1359 0.00193169040479819 EPHB2 M - Other Metabolism axon ISS integral to plasma membrane ISS cell soma IEA dendrite ISS positive regulation of synaptogenesis ISS retinal ganglion cell axon guidance IEA inner ear morphogenesis ISS urogenital system development ISS peptidyl-tyrosine phosphorylation ISS central nervous system projection neuron axonogenesis IEA angiogenesis ISS eye morphogenesis (sensu Vertebrata) IEA corpus callosum development ISS axonal fasciculation ISS palate development ISS negative regulation of axonogenesis IEA learning IEA optic nerve morphogenesis IEA regulation of body fluids ISS positive regulation of long-term neuronal synaptic plasticity IEA transmembrane-ephrin receptor activity ISS ATP binding IEA axon guidance receptor activity IEA Ephrin type-B receptor 2; 2.7.10.1; Developmentally-regulated Eph-related tyrosine kinase; ELK-related tyrosine kinase; EPH tyrosine kinase 3; EPH-like kinase 5; EK5; hEK5; Renal carcinoma antigen NY-REN-47; Tyrosine-protein kinase TYRO5; Tyrosine-protein kinase receptor EPH-3; Precursor 10508479 15300251 16155194 1648701 16710414 17344846 17897949 18691976 19369195 7601466 7688222 7898931 8033077 8589679 9267020 9696046 9933164 NA EPHB2 1 Ephrin type-B receptor 2 2.7.10.1 Developmentally-regulated Eph-related tyrosine kinase ELK-related tyrosine kinase EPH tyrosine kinase 3 EPH-like kinase 5 EK5 hEK5 Renal carcinoma antigen NY-REN-47 Tyrosine-protein kinase TYRO5 Tyrosine-protein kinase receptor EPH-3 Precursor gene 1291 0.0222487677836032 D - Genome Maintenance lipid particle IEA transport vesicle IDA perinuclear region IDA Golgi apparatus ISS cell surface IEA nucleus IEA cytosol IEA extrinsic to internal side of plasma membrane IDA protein complex IEA Golgi membrane IEA membrane IDA integral to plasma membrane IDA caveola IDA acrosomal membrane IEA regulation of mitosis IEP positive regulation of endothelial cell proliferation IEA negative regulation of endothelial cell proliferation ISS synaptic transmission IEA skeletal muscle fiber development ISS mitochondrion organization and biogenesis ISS vesicle fusion IDA endoplasmic reticulum organization and biogenesis ISS protein oligomerization IEA negative regulation of transforming growth factor beta receptor signaling pathway IEA vesicle docking IDA protein homodimerization activity IDA Caveolin-2 10218480 12091389 12690205 14702039 15489334 15504032 18081315 18669648 21269460 8552590 9361015 9738464 NA CAV2 -1 Caveolin-2 gene 1291 1.52120783456378E-4 C - Cellular Fate and Organization axon ISS protein complex IDA nuclear membrane ISS Z disc ISS Golgi apparatus IDA plasma membrane IDA focal adhesion IEA ruffle IDA dendrite ISS growth cone IEA cytosol TAS response to hypoxia IEA T cell receptor signaling pathway TAS actin cytoskeleton reorganization IDA T cell costimulation TAS apoptosis IEA exocytosis IEA dendrite development IEA protein amino acid autophosphorylation IDA neuromuscular junction development IEA axon guidance TAS wound healing IMP positive regulation of stress fiber formation IMP receptor clustering IEA positive regulation of JNK activity IMP branching morphogenesis of a tube IMP protein serine/threonine kinase activity IDA ATP binding IEA Serine/threonine-protein kinase PAK 1; 2.7.11.1; Alpha-PAK; p21-activated kinase 1; PAK-1; p65-PAK 10026169 10551809 10975528 10995762 11733498 11804587 12624090 12876277 14585966 15169762 15489334 15611088 15831477 15833848 15893667 16101281 16278681 16554811 16964243 17726028 17989089 18325335 18669648 18716323 19690332 21269460 21406692 22153498 22669945 8805275 9032240 9395435 9528787 9774440 NA PAK1 1 Serine/threonine-protein kinase PAK 1 2.7.11.1 Alpha-PAK p21-activated kinase 1 PAK-1 p65-PAK gene 1339 1.97105580233811E-7 PHACTR2 C - Cellular Fate and Organization protein phosphatase inhibitor activity IEA Phosphatase and actin regulator 2 14574404 14702039 15489334 17081983 17974005 9734811 NA PHAR2 -1 Phosphatase and actin regulator 2 gene 1291 0.015193707803644 APC D - Genome Maintenance cytoplasmic microtubule IEA centrosome IDA adherens junction IEA beta-catenin destruction complex IDA kinetochore IDA nucleus IDA tight junction IDA lateral plasma membrane IDA lamellipodium IDA cytosol TAS mitotic spindle checkpoint IMP positive regulation of protein catabolic process IC chromosome organization and biogenesis IEA axis specification IEA negative regulation of cell proliferation IDA regulation of nitrogen metabolic process IEA negative regulation of odontogenesis IEA negative regulation of cyclin-dependent protein kinase activity IDA cytoplasmic microtubule organization and biogenesis IEA proximal/distal pattern formation IEA thymus development IEA dorsal/ventral pattern formation IEA axonogenesis IEA anterior/posterior pattern formation IEA muscle maintenance IEA cell structure disassembly during apoptosis TAS negative regulation of MAPKKK cascade IEA positive regulation of epithelial cell differentiation IEA positive regulation of pseudopodium formation IMP positive regulation of cell division IEA cell cycle arrest IDA cell adhesion NAS mitotic metaphase/anaphase transition IEA hair follicle development IEA somatic stem cell maintenance IEA positive regulation of microtubule polymerization IEA negative regulation of apoptosis IEA positive regulation of cell migration IMP positive regulation of apoptosis IMP cytokinesis after mitosis IMP kidney development IEA regulation of attachment of spindle microtubules to kinetochore NAS regulation of osteoclast differentiation IEA response to DNA damage stimulus IDA positive regulation of cell adhesion IEA regulation of osteoblast differentiation IEA protein complex assembly IDA cell migration IMP negative regulation of microtubule depolymerization IDA skin development IEA protein kinase regulator activity IDA microtubule plus-end binding IDA Adenomatous polyposis coli protein; Protein APC; Deleted in polyposis 2.5 10470088 10666372 10782927 10811618 10926498 10947987 11691822 11707392 1310068 1338691 1338764 1338904 14514668 15355978 1651562 1651563 16611247 1678319 16959974 17081983 17599059 18220336 18281465 18669648 19151759 19632184 19690332 19893577 20068231 20509626 20937854 21406692 21498506 21871439 22128170 7661930 7833149 7833931 8111410 8259519 8638125 8764128 8940264 8990002 9188857 9419979 9724771 9731522 9731533 9950360 9973276 NA APC -1 Adenomatous polyposis coli protein Protein APC Deleted in polyposis 2.5 gene 1291 0.188280548365469 ARHGAP6 C - Cellular Fate and Organization actin filament NAS cytosol TAS negative regulation of stress fiber formation IMP focal adhesion formation IEA actin filament polymerization NAS phospholipase C activation IDA Rho protein signal transduction NAS negative regulation of focal adhesion formation IMP phospholipase activator activity IDA SH3/SH2 adaptor activity TAS Rho GTPase activator activity ISS Rho GTPase-activating protein 6; Rho-type GTPase-activating protein 6; Rho-type GTPase-activating protein RhoGAPX-1 10699171 15489334 18088087 21269460 9417914 NA RHG06 -1 Rho GTPase-activating protein 6 Rho-type GTPase-activating protein 6 Rho-type GTPase-activating protein RhoGAPX-1 gene 1317 0.00275312073119889 TOM1L1 C - Cellular Fate and Organization Golgi stack IEA lysosome TAS endosome membrane IEA endosome IDA cytosol IDA intracellular protein transport IEA ubiquitin-dependent protein catabolic process via the multivesicular body pathway NAS ubiquitin binding TAS protein kinase activator activity IEA TOM1-like protein 1; Src-activating and signaling molecule protein; Target of Myb-like protein 1 10329004 14702039 17525332 18669648 19690332 20068231 NA TM1L1 1 TOM1-like protein 1 Src-activating and signaling molecule protein Target of Myb-like protein 1 gene 1291 0.154619333409719 RIT1 C - Cellular Fate and Organization plasma membrane TAS nerve growth factor receptor signaling pathway TAS small GTPase mediated signal transduction TAS calmodulin binding TAS GTPase activity IEA GTP binding TAS GTP-binding protein Rit1; Ras-like protein expressed in many tissues; Ras-like without CAAX protein 1 10545207 14702039 15489334 15632082 16710414 8824319 8918462 NA RIT1 1 GTP-binding protein Rit1 Ras-like protein expressed in many tissues Ras-like without CAAX protein 1 gene 1580 0.106951875741358 BMP2 D - Genome Maintenance cell surface IDA extracellular region TAS extracellular space IEA ureteric bud branching ISS negative regulation of cell proliferation IDA positive regulation of odontogenesis ISS cartilage development IEA protein destabilization IEA inflammatory response ISS Notch signaling pathway ISS odontogenesis (sensu Vertebrata) ISS cardiac muscle cell differentiation IMP cardiac muscle morphogensis ISS response to hypoxia ISS inner ear development ISS positive regulation of cell migration ISS positive regulation of bone mineralization IDA positive regulation of apoptosis IDA embryonic heart tube anterior/posterior pattern formation ISS telencephalon regionalization ISS proteoglycan metabolic process IEA negative regulation of transcription from RNA polymerase II promoter IDA negative regulation of progression through cell cycle IDA embryonic development (sensu Mammalia) ISS osteoblast differentiation IDA positive regulation of osteoblast differentiation IDA positive regulation of astrocyte differentiation ISS negative regulation of insulin-like growth factor receptor signaling pathway IDA positive regulation of endothelial cell proliferation IDA positive regulation of neuron differentiation ISS positive regulation of fat cell differentiation ISS regulation of odontogenesis (sensu Vertebrata) IEA growth IEA negative regulation of aldosterone biosynthetic process IDA protein heterodimerization activity IDA phosphatase activator activity IDA SMAD binding IDA retinol dehydrogenase activity ISS Bone morphogenetic protein 2; BMP-2; Bone morphogenetic protein 2A; BMP-2A; Precursor 10074410 11780052 15020244 20555025 3201241 NA BMP2 -1 Bone morphogenetic protein 2 BMP-2 Bone morphogenetic protein 2A BMP-2A Precursor gene 1471 1.0 ESR2 C - Cellular Fate and Organization mitochondrion IDA nucleoplasm TAS extracellular region NAS positive regulation of transcription factor activity IDA negative regulation of cell growth NAS ovarian follicle development IEA positive regulation of apoptosis IEA transcription initiation from RNA polymerase II promoter TAS brain development IEA negative regulation of epithelial cell proliferation IEA cell-cell signaling TAS negative regulation of transcription from RNA polymerase II promoter IDA neuron migration IEA estrogen receptor signaling pathway TAS transcription coactivator activity TAS estrogen receptor activity TAS zinc ion binding IEA ligand-dependent nuclear receptor activity NAS receptor antagonist activity NAS steroid binding TAS Estrogen receptor beta; ER-beta; Nuclear receptor subfamily 3 group A member 2 10681503 10964723 11113208 11579095 12039952 12415108 12508121 14702039 14759258 15047147 15199063 15489334 15862947 16938840 19126643 8769313 9267036 9325313 9473491 9636657 9671811 9685228 NA ESR2 0 Estrogen receptor beta ER-beta Nuclear receptor subfamily 3 group A member 2 TF 7358 1.0 ESR1 D - Genome Maintenance Golgi apparatus IEA plasma membrane IDA chromatin remodeling complex NAS nucleoplasm TAS integral to membrane IEA transcription initiation from RNA polymerase II promoter TAS androgen metabolic process IEA regulation of apoptosis IEA positive regulation of fibroblast proliferation IEA negative regulation of transcription factor activity IDA antral ovarian follicle growth IEA positive regulation of nitric oxide biosynthetic process IDA positive regulation of transcription factor activity IDA positive regulation of retinoic acid receptor signaling pathway IDA positive regulation of nitric-oxide synthase activity IDA positive regulation of transcription from RNA polymerase II promoter IDA epithelial cell development IEA response to estradiol stimulus IDA male gonad development IEA negative regulation of I-kappaB kinase/NF-kappaB cascade IDA chromatin binding IEA zinc ion binding IEA nitric-oxide synthase regulator activity NAS steroid binding IEA Estrogen receptor; ER; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1 10359819 10409727 10428798 10567404 10619354 10681512 10816575 10942433 10970861 11075817 11113208 11265755 11358960 11477071 11581164 11682626 11875103 11971969 12039952 12093804 12415108 12554772 12682286 12917342 14574404 15047147 15078875 15199063 15489334 1577818 15891768 15940264 16043358 16165085 16427018 16603732 16684779 17006958 17043237 17085477 17224074 17311814 17347654 17587566 17658481 17914104 17932106 17974005 17998543 18247370 18563714 18657504 19117995 19339517 19350539 19383985 19423554 19636373 19712589 19718048 20705611 21104395 21330404 21937726 22031296 22083956 2247153 2792078 3753802 3754034 7476978 7539106 7651415 7838153 7916651 8221895 8600466 8961262 8999954 9195227 9328340 9338790 9600906 9619507 9627117 9875847 NA ESR1 0 Estrogen receptor ER ER-alpha Estradiol receptor Nuclear receptor subfamily 3 group A member 1 TF 1291 0.00458749974480071 RPA3 D - Genome Maintenance cytoplasm IDA nucleoplasm TAS DNA replication factor A complex TAS S phase of mitotic cell cycle TAS G1/S transition of mitotic cell cycle TAS DNA strand elongation during DNA replication TAS transcription-coupled nucleotide-excision repair TAS DNA recombinase assembly TAS telomere maintenance via recombination TAS cell cycle checkpoint TAS M/G1 transition of mitotic cell cycle TAS nucleotide-excision repair, DNA gap filling TAS nucleotide-excision repair, DNA damage removal TAS telomere maintenance via semi-conservative replication TAS single-stranded DNA binding TAS Replication protein A 14 kDa subunit; RP-A p14; Replication factor A protein 3; RF-A protein 3 11927569 12853948 15489334 19116208 19996105 21269460 7760808 8454588 NA RFA3 1 Replication protein A 14 kDa subunit RP-A p14 Replication factor A protein 3 RF-A protein 3 gene 1291 0.0922110429307214 LMO7 F - Protein Fate cytoplasm TAS ubiquitin ligase complex NAS nucleus TAS ubiquitin-protein ligase activity NAS zinc ion binding IEA LIM domain only protein 7; LMO-7; F-box only protein 20; LOMP 10048485 10531035 11935316 12168954 15057823 16959974 16964243 17081983 17924679 18220336 18669648 18691976 19690332 20068231 21269460 21406692 9826547 NA LMO7 -1 LIM domain only protein 7 LMO-7 F-box only protein 20 LOMP gene 18716 0.224298088631539 reported 1 mir 1291 0.172836979987125 DLG5 C - Cellular Fate and Organization cytoplasm TAS cell-cell adherens junction IEA plasma membrane NAS cell-cell adhesion NAS negative regulation of cell proliferation TAS regulation of apoptosis IEA cytoskeletal protein binding IDA beta-catenin binding IDA receptor signaling complex scaffold activity NAS Disks large homolog 5; Discs large protein P-dlg; Placenta and prostate DLG 11876824 12657639 15164054 15489334 18669648 18987736 20068231 21406692 9628581 9738934 NA DLG5 1 Disks large homolog 5 Discs large protein P-dlg Placenta and prostate DLG gene 1291 0.00238951736395554 DYNC2LI1 C - Cellular Fate and Organization microtubule IEA apical part of cell ISS axonemal dynein complex ISS intraflagellar transport particle IEA motile primary cilium ISS cilium axoneme ISS cytosol TAS antigen processing and presentation of exogenous peptide antigen via MHC class II TAS cilium biogenesis IEA determination of left/right symmetry IEA motor activity IEA Cytoplasmic dynein 2 light intermediate chain 1; Dynein 2 light intermediate chain 10810093 11907264 15489334 15815621 17974005 21269460 NA DC2L1 -1 Cytoplasmic dynein 2 light intermediate chain 1 Dynein 2 light intermediate chain gene 1291 0.00110324228664262 LMO2 T - Transcription transcription factor complex IDA negative regulation of erythrocyte differentiation IEA multicellular organismal development TAS mRNA transcription from RNA polymerase II promoter IDA embryonic hemopoiesis IEA cofactor binding IPI chromatin binding IEA zinc ion binding IEA Rhombotin-2; Cysteine-rich protein TTG-2; LIM domain only protein 2; LMO-2; T-cell translocation protein 2 15489334 16314316 1923511 9129143 NA RBTN2 -1 Rhombotin-2 Cysteine-rich protein TTG-2 LIM domain only protein 2 LMO-2 T-cell translocation protein 2 gene 1291 8.39665050619849E-5 WASF3 N - Not Matched cytoplasm IEA cytoskeleton IEA lamellipodium IEA regulation of cell shape IMP oligodendrocyte development IEA lamellipodium biogenesis IEA actin filament polymerization TAS positive regulation of myelination IEA Wiskott-Aldrich syndrome protein family member 3; WASP family protein member 3; Protein WAVE-3; Verprolin homology domain-containing protein 3 10048485 10381382 12168954 12856283 15057823 17623672 21834987 NA WASF3 -1 Wiskott-Aldrich syndrome protein family member 3 WASP family protein member 3 Protein WAVE-3 Verprolin homology domain-containing protein 3 gene 1291 0.187767338615346 PCBD2 T - Transcription mitochondrion IEA nucleus IEA protein homotetramerization IEA tetrahydrobiopterin biosynthetic process IEA positive regulation of transcription, DNA-dependent IDA protein heterooligomerization IEA phenylalanine 4-monooxygenase activity IEA 4-alpha-hydroxytetrahydrobiopterin dehydratase activity IEA Pterin-4-alpha-carbinolamine dehydratase 2; PHS 2; 4.2.1.96; 4-alpha-hydroxy-tetrahydropterin dehydratase 2; DcoH-like protein DCoHm; Dimerization cofactor of hepatocyte nuclear factor 1 from muscle; HNF-1-alpha dimerization cofactor 11230166 11980910 15372022 15489334 21269460 NA PHS2 1 Pterin-4-alpha-carbinolamine dehydratase 2 PHS 2 4.2.1.96 4-alpha-hydroxy-tetrahydropterin dehydratase 2 DcoH-like protein DCoHm Dimerization cofactor of hepatocyte nuclear factor 1 from muscle HNF-1-alpha dimerization cofactor gene 1291 0.0717638596053337 CHAF1A D - Genome Maintenance DNA replication IEA regulation of transcription, DNA-dependent IEA cell cycle IEA DNA repair IEA protein complex assembly TAS DNA replication-dependent nucleosome assembly TAS transcription, DNA-dependent IEA chromatin binding TAS unfolded protein binding TAS Chromatin assembly factor 1 subunit A; CAF-1 subunit A; Chromatin assembly factor I p150 subunit; CAF-I 150 kDa subunit; CAF-I p150; hp150 10052459 10648606 10893180 11250073 11296234 12697822 12771185 12837248 15057824 15327775 15489334 15882967 17081983 18220336 18669648 19690332 20068231 20562864 21406692 7600578 NA CAF1A 1 Chromatin assembly factor 1 subunit A CAF-1 subunit A Chromatin assembly factor I p150 subunit CAF-I 150 kDa subunit CAF-I p150 hp150 gene 1291 0.00655360402115204 N - Not Matched cytoskeleton IDA actomyosin structure organization and biogenesis IEA regulation of smooth muscle contraction TAS Calponin-1; Basic calponin; Calponin H1, smooth muscle 14702039 15489334 8526917 9332369 NA CNN1 -1 Calponin-1 Basic calponin Calponin H1, smooth muscle gene 1291 2.11275848469997E-4 METTL21B N - Not Matched intracellular IDA integral to membrane IEA methyltransferase activity IEA Protein-lysine methyltransferase METTL21B; 2.1.1.-; Hepatocellular carcinoma-associated antigen 557a; Methyltransferase-like protein 21B 14702039 15489334 17974005 NA MT21B 1 Protein-lysine methyltransferase METTL21B 2.1.1.- Hepatocellular carcinoma-associated antigen 557a Methyltransferase-like protein 21B gene 1291 0.0211472487140471 EPAS1 C - Cellular Fate and Organization transcription factor complex IDA cytosol TAS transcription from RNA polymerase II promoter TAS lung development IEA embryonic placenta development IEA regulation of transcription from RNA polymerase II promoter in response to oxidative stress IEA angiogenesis IEA signal transduction TAS norepinephrine metabolic process IEA cardiac chronotropy IEA blood vessel remodeling IEA positive regulation of transcription from RNA polymerase II promoter IGI erythrocyte differentiation IEA cell maturation IEA surfactant homeostasis IEA mitochondrion organization and biogenesis IEA visual perception IEA myoblast cell fate commitment ISS signal transducer activity IEA DNA binding IGI Endothelial PAS domain-containing protein 1; EPAS-1; Basic-helix-loop-helix-PAS protein MOP2; Class E basic helix-loop-helix protein 73; bHLHe73; HIF-1-alpha-like factor; HLF; Hypoxia-inducible factor 2-alpha; HIF-2-alpha; HIF2-alpha; Member of PAS protein 2; PAS domain-containing protein 2 10202154 15489334 18184961 18378852 19208626 22367913 9000051 9079689 NA EPAS1 -1 Endothelial PAS domain-containing protein 1 EPAS-1 Basic-helix-loop-helix-PAS protein MOP2 Class E basic helix-loop-helix protein 73 bHLHe73 HIF-1-alpha-like factor HLF Hypoxia-inducible factor 2-alpha HIF-2-alpha HIF2-alpha Member of PAS protein 2 PAS domain-containing protein 2 TF 1291 0.0717638596053337 DEPDC1B C - Cellular Fate and Organization cytosol TAS positive regulation of GTPase activity IEA regulation of small GTPase mediated signal transduction TAS small GTPase mediated signal transduction TAS GTPase activator activity IEA DEP domain-containing protein 1B; HBV X-transactivated gene 8 protein; HBV XAg-transactivated protein 8 14702039 15372022 15489334 19690332 21406692 NA DEP1B 1 DEP domain-containing protein 1B HBV X-transactivated gene 8 protein HBV XAg-transactivated protein 8 gene 1600 1.67504250905014E-5 SESN1 D - Genome Maintenance nucleus TAS negative regulation of cell proliferation TAS cell cycle arrest TAS response to DNA damage stimulus TAS Sestrin-1; p53-regulated protein PA26 12607115 14574404 14702039 15105503 15489334 17525332 19690332 9926927 NA SESN1 -1 Sestrin-1 p53-regulated protein PA26 gene 1291 0.12981008547549 CASK C - Cellular Fate and Organization basolateral plasma membrane IEA presynaptic membrane ISS cytoplasm IDA intercellular junction IDA nuclear lamina IDA nucleolus IDA actin cytoskeleton TAS nuclear matrix IDA basement membrane IEA cytosol IEA positive regulation of transcription from RNA polymerase II promoter IEA cell adhesion TAS negative regulation of cell-matrix adhesion IMP protein serine/threonine kinase activity IEA guanylate kinase activity TAS ATP binding IEA Peripheral plasma membrane protein CASK; hCASK; 2.7.11.1; Calcium/calmodulin-dependent serine protein kinase; Protein lin-2 homolog 11003712 15489334 15772651 17344846 18423203 19012874 19165920 19200522 19377476 9546224 9660868 NA CSKP 1 Peripheral plasma membrane protein CASK hCASK 2.7.11.1 Calcium/calmodulin-dependent serine protein kinase Protein lin-2 homolog gene 1291 0.17273753523313 HPCAL1 N - Not Matched calcium ion binding TAS Hippocalcin-like protein 1; Calcium-binding protein BDR-1; HLP2; Visinin-like protein 3; VILIP-3 15489334 21269460 8038222 NA HPCL1 -1 Hippocalcin-like protein 1 Calcium-binding protein BDR-1 HLP2 Visinin-like protein 3 VILIP-3 gene 1291 0.536786016025785 NLRP1 M - Other Metabolism nucleus IDA cytosol TAS positive regulation of interleukin-1 beta secretion ISS innate immune response TAS regulation of inflammatory response IC induction of apoptosis NAS response to muramyl dipeptide ISS neuron apoptosis IDA defense response to bacterium ISS ATP binding IDA caspase activator activity NAS NACHT, LRR and PYD domains-containing protein 1; Caspase recruitment domain-containing protein 7; Death effector filament-forming ced-4-like apoptosis protein; Nucleotide-binding domain and caspase recruitment domain 10231032 11076957 11113115 11250163 11270363 12191486 14527388 15212762 15285719 17164409 17349957 17377159 17974005 NA NALP1 -1 NACHT, LRR and PYD domains-containing protein 1 Caspase recruitment domain-containing protein 7 Death effector filament-forming ced-4-like apoptosis protein Nucleotide-binding domain and caspase recruitment domain gene 2283 1.0 ZNF263 T - Transcription cytoplasm IDA microtubule cytoskeleton IDA nucleus IDA viral reproduction IEA negative regulation of transcription, DNA-dependent IEA transcription, DNA-dependent IEA transcription factor activity TAS zinc ion binding IEA DNA binding IEA Zinc finger protein 263; Zinc finger protein FPM315; Zinc finger protein with KRAB and SCAN domains 12 14702039 15489334 15616553 9256059 NA ZN263 0 Zinc finger protein 263 Zinc finger protein FPM315 Zinc finger protein with KRAB and SCAN domains 12 TF 1400 0.017761972616051 TMEM183A N - Not Matched integral to membrane IEA Transmembrane protein 183A 14702039 15489334 NA T183A 1 Transmembrane protein 183A gene 1291 0.015193707803644 PIK3IP1 C - Cellular Fate and Organization integral to membrane IEA negative regulation of phosphoinositide 3-kinase activity IDA negative regulation of phosphoinositide 3-kinase cascade IDA Phosphoinositide-3-kinase-interacting protein 1; Kringle domain-containing protein HGFL; Precursor 10591208 14702039 15340161 15461802 15489334 22171320 NA P3IP1 -1 Phosphoinositide-3-kinase-interacting protein 1 Kringle domain-containing protein HGFL Precursor gene 1291 0.0285443010498714 NOTCH4 C - Cellular Fate and Organization Golgi membrane TAS cell surface IDA integral to plasma membrane TAS endoplasmic reticulum membrane TAS extracellular region TAS nucleoplasm TAS cytosol TAS hemopoiesis TAS patterning of blood vessels ISS transcription initiation from RNA polymerase II promoter TAS Notch receptor processing TAS cell fate determination TAS endothelial cell morphogenesis IEA mammary gland development IDA embryonic development ISS activation of Notch receptor target transcription factor TAS negative regulation of endothelial cell differentiation ISS protein heterodimerization activity TAS calcium ion binding TAS receptor activity TAS Neurogenic locus notch homolog protein 4; Notch 4; hNotch4; Notch 4 extracellular truncation; Notch 4 intracellular domain; Precursor 10079256 11101851 12370315 14574404 9168133 9693032 NA NOTC4 -1 Neurogenic locus notch homolog protein 4 Notch 4 hNotch4 Notch 4 extracellular truncation Notch 4 intracellular domain Precursor gene 1291 1.0 HSF2 D - Genome Maintenance cytoplasm IEA nucleus IDA transcription from RNA polymerase II promoter TAS positive regulation of transcription from RNA polymerase II promoter IDA response to stress IEA spermatogenesis IEA transcription factor activity TAS transcription coactivator activity TAS Heat shock factor protein 2; HSF 2; Heat shock transcription factor 2; HSTF 2 14574404 14702039 15489334 1871106 8339932 NA HSF2 0 Heat shock factor protein 2 HSF 2 Heat shock transcription factor 2 HSTF 2 TF 1291 0.0142201767149274 PLAC8 C - Cellular Fate and Organization positive regulation of cell proliferation IEA negative regulation of apoptosis IEA negative regulation of body size IEA brown fat cell differentiation IEA positive regulation of transcription from RNA polymerase II promoter IEA response to cold IEA defense response to bacterium IEA chromatin binding IEA Placenta-specific gene 8 protein; Protein C15 11042152 12384430 NA PLAC8 -1 Placenta-specific gene 8 protein Protein C15 gene 1291 0.0262453699169434 EMCN N - Not Matched plasma membrane IEA extracellular region IEA integral to membrane IEA Endomucin; Endomucin-2; Gastric cancer antigen Ga34; Mucin-14; MUC-14; Precursor 11418125 12485444 14702039 14722670 15489334 15815621 NA MUCEN -1 Endomucin Endomucin-2 Gastric cancer antigen Ga34 Mucin-14 MUC-14 Precursor gene 1291 9.22127029133089E-4 F - Protein Fate mitochondrial outer membrane TAS protein targeting to mitochondrion TAS cellular protein metabolic process TAS Metaxin-2; Mitochondrial outer membrane import complex protein 2 10381257 14702039 15489334 15815621 21269460 22114354 NA MTX2 1 Metaxin-2 Mitochondrial outer membrane import complex protein 2 gene 1291 0.00656102737184934 ELTD1 A - Transport and Sensing plasma membrane IEA integral to membrane TAS neuropeptide signaling pathway IEA G-protein coupled receptor activity TAS calcium ion binding IEA EGF, latrophilin and seven transmembrane domain-containing protein 1; EGF-TM7-latrophilin-related protein; ETL protein; Precursor 11050079 12975309 15489334 16335952 16710414 NA ELTD1 -1 EGF, latrophilin and seven transmembrane domain-containing protein 1 EGF-TM7-latrophilin-related protein ETL protein Precursor gene 1291 0.00655360402115204 LGALSL N - Not Matched intracellular IDA carbohydrate binding IEA Galectin-related protein; Lectin galactoside-binding-like protein 11042152 14702039 15489334 16682780 18320588 18433051 18669648 20068231 21269460 NA LEGL -1 Galectin-related protein Lectin galactoside-binding-like protein gene 1291 0.132427427935845 C - Cellular Fate and Organization cytosol TAS blood coagulation TAS Ras protein signal transduction IEA leukocyte migration TAS transmembrane receptor protein tyrosine kinase signaling pathway IEA cell surface receptor linked signal transduction TAS phospholipid binding IEA receptor signaling protein activity IEA Docking protein 2; Downstream of tyrosine kinase 2; p56(dok-2) 15144186 15489334 15592455 19690332 9478921 NA DOK2 -1 Docking protein 2 Downstream of tyrosine kinase 2 p56(dok-2) gene 1291 0.145385885608534 C - Cellular Fate and Organization collagen type III IMP endoplasmic reticulum lumen TAS extracellular space IDA response to radiation IDA blood vessel development IEA platelet activation NAS gut development IEA heart development IMP skeletal development IEA peptide cross-linking IDA negative regulation of immune response IMP cell-matrix adhesion IDA integrin-mediated signaling pathway IMP axon guidance TAS collagen fibril organization IMP skin development IMP transforming growth factor beta receptor signaling pathway IDA fibril organization and biogenesis IMP integrin binding IMP platelet-derived growth factor binding IDA metal ion binding IEA extracellular matrix structural constituent IMP Collagen alpha-1(III) chain; Precursor 10706896 10819545 10923041 11168790 11566270 12694234 12786757 1352273 1357232 1370809 1496983 15489334 15815621 1672129 16959974 18272325 1895316 2145268 2235526 2243125 23001006 2349939 2492273 2579949 2764886 2777083 2780304 2808425 3211760 3357782 3405773 3754462 3858826 557335 6096827 6246925 687591 7016180 7487954 7749417 7833919 7864881 7912131 8019562 8098182 8255472 8317500 8411057 8514866 8664902 8680408 8884076 8990011 9036918 9101290 9147870 9452103 NA CO3A1 1 Collagen alpha-1(III) chain Precursor gene 1291 0.089123537715456 DST D - Genome Maintenance intermediate filament IEA hemidesmosome IDA axon IEA Z disc IDA nucleus IDA nuclear envelope IEA actin cytoskeleton IDA basement membrane TAS basal plasma membrane NAS microtubule cytoskeleton IDA endoplasmic reticulum membrane IEA cytoplasmic membrane-bound vesicle IDA integral to membrane IEA intermediate filament cytoskeleton IDA cell cortex IEA leading edge IDA H zone IEA retrograde axon cargo transport IEA regulation of microtubule polymerization or depolymerization IEA intermediate filament cytoskeleton organization and biogenesis IEP response to wounding IDA microtubule cytoskeleton organization and biogenesis IDA cytoplasmic microtubule organization and biogenesis IEA axonogenesis IEA maintenance of cell polarity IMP integrin-mediated signaling pathway NAS cell motility involved in cell locomotion IMP hemidesmosome assembly IDA cell cycle arrest IEA cell adhesion IEA microtubule plus-end binding IDA calcium ion binding IEA protein homodimerization activity IDA Dystonin; 230 kDa bullous pemphigoid antigen; 230/240 kDa bullous pemphigoid antigen; Bullous pemphigoid antigen 1; BPA; Bullous pemphigoid antigen; Dystonia musculorum protein; Hemidesmosomal plaque protein 10428034 10637308 11375975 11751855 12168954 12482924 12802069 14574404 14702039 15489334 1712022 1717441 18669648 19403692 19632184 19932097 2090522 21269460 21406692 22419821 22522446 2461961 8010969 8345227 8575775 8621649 8752219 9872452 NA DYST -1 Dystonin 230 kDa bullous pemphigoid antigen 230/240 kDa bullous pemphigoid antigen Bullous pemphigoid antigen 1 BPA Bullous pemphigoid antigen Dystonia musculorum protein Hemidesmosomal plaque protein gene 1291 0.0449492875329337 C - Cellular Fate and Organization mitochondrion IEA intermediate filament IEA desmosome IEA basolateral plasma membrane IEA plasma membrane IDA cornified envelope IDA cell-cell adhesion IEA peptide cross-linking IDA intermediate filament organization ISS keratinocyte differentiation IDA skin development IEA cell structure disassembly during apoptosis TAS structural constituent of cytoskeleton TAS protein binding, bridging IDA Desmoplakin; DP; 250/210 kDa paraneoplastic pemphigus antigen 10594734 11063735 11841538 12101406 12373648 12482924 12802069 12875771 14574404 15489334 15941723 16175511 1689290 1731325 18220336 18669648 18691976 19369195 19690332 19863551 20031617 20068231 21062920 21269460 21406692 21536047 2391353 9348293 9651377 9887343 NA DESP 1 Desmoplakin DP 250/210 kDa paraneoplastic pemphigus antigen gene 1291 0.12035157949123 EMC1 ER membrane protein complex subunit 1; Precursor 14702039 15489334 16303743 16710414 17974005 19159218 19690332 21269460 22119785 7788527 NA EMC1 1 ER membrane protein complex subunit 1 Precursor gene 198304 0.473335538053235 known -1 mir 1291 1.0 CLOCK C - Cellular Fate and Organization transcription factor complex IPI chromosome IDA cytosol TAS signal transduction TAS histone acetylation IEA photoperiodism TAS DNA damage checkpoint IMP signal transducer activity IEA histone acetyltransferase activity IEA Circadian locomoter output cycles protein kaput; hCLOCK; 2.3.1.48; Class E basic helix-loop-helix protein 8; bHLHe8 10198158 14702039 15489334 16474406 21659603 9205841 NA CLOCK 0 Circadian locomoter output cycles protein kaput hCLOCK 2.3.1.48 Class E basic helix-loop-helix protein 8 bHLHe8 TF 1291 6.17614106217859E-5 GLB1L2 N - Not Matched extracellular region IEA carbohydrate metabolic process IEA beta-galactosidase activity IEA cation binding IEA Beta-galactosidase-1-like protein 2; 3.2.1.-; Precursor 12975309 14702039 15489334 16303743 16554811 NA GLBL2 1 Beta-galactosidase-1-like protein 2 3.2.1.- Precursor gene 1291 0.0714360801321983 TMOD1 N - Not Matched membrane IEA cortical cytoskeleton IEA myofibril IEA cytosol TAS adult locomotory behavior IEA muscle filament sliding TAS myofibril assembly IEA Tropomodulin-1; Erythrocyte tropomodulin; E-Tmod 11054557 1370827 14702039 15164053 15489334 21269460 8002995 NA TMOD1 -1 Tropomodulin-1 Erythrocyte tropomodulin E-Tmod gene 85694 0.00223066932345136 reported 1 mir 10477 0.08344347413064 novel 1 mir 1291 0.0716081296734786 C - Cellular Fate and Organization axon IDA cytoplasm ISS intrinsic to internal side of plasma membrane IBA nucleus ISS dendrite IDA metanephros development ISS artery morphogenesis ISS eye morphogenesis (sensu Vertebrata) ISS negative regulation of transcription factor import into nucleus ISS negative regulation of neuroblast proliferation ISS heart development ISS negative regulation of Ras protein signal transduction IBA positive regulation of neuron apoptosis ISS MAPKKK cascade ISS collagen fibril organization ISS smooth muscle development ISS regulation of long-term neuronal synaptic plasticity IEA forebrain astrocyte development ISS negative regulation of cell migration IMP phosphoinositide 3-kinase cascade ISS sympathetic nervous system development ISS negative regulation of neurotransmitter secretion IEA osteoblast differentiation ISS regulation of blood vessel endothelial cell migration IMP liver development ISS striated muscle development IEA regulation of synaptic transmission, GABAergic IEA visual learning ISS wound healing ISS regulation of cell-matrix adhesion ISS negative regulation of cell-matrix adhesion IEA actin cytoskeleton organization and biogenesis ISS cerebral cortex development ISS negative regulation of Rac protein signal transduction IEA adrenal gland development ISS spinal cord development ISS myelination in the peripheral nervous system ISS negative regulation of fibroblast proliferation IEA regulation of bone resorption ISS Ras protein signal transduction ISS negative regulation of MAPK activity ISS response to hypoxia ISS regulation of angiogenesis IMP negative regulation of osteoclast differentiation IEA positive regulation of adenylate cyclase activity ISS forebrain morphogenesis ISS negative regulation of astrocyte differentiation IEA positive regulation of endothelial cell proliferation IEA negative regulation of endothelial cell proliferation IMP negative regulation of angiogenesis IEA negative regulation of oligodendrocyte differentiation ISS neural tube development IEA pigmentation ISS Ras GTPase activator activity IDA Neurofibromin; Neurofibromatosis-related protein NF-1; Neurofibromin truncated 10220149 10336779 10607834 10712197 10980545 11258625 11704931 11727199 11735023 11857752 12522551 12552569 12707950 12746402 1302608 1339276 1457041 15060124 15146469 15520408 15523642 1568247 15948193 16380919 1662505 16625196 16959974 1783401 18220336 18669648 18691976 1923522 19369195 19690332 19845691 20068231 2114220 2116237 2121370 2121371 2125369 21269460 2134734 21406692 21838856 22108604 7570581 7774960 7904209 7981679 7981724 8081387 8317503 8417346 8544190 8602361 8807336 8825042 8834249 9002664 9003501 9101300 9150739 9298829 9668168 NA NF1 1 Neurofibromin Neurofibromatosis-related protein NF-1 Neurofibromin truncated gene 1291 0.162837055010795 ROBO2 C - Cellular Fate and Organization cell surface IDA integral to membrane IEA axolemma ISS metanephros development ISS retinal ganglion cell axon guidance ISS negative regulation of negative chemotaxis IDA ureteric bud development IMP olfactory bulb interneuron development ISS negative regulation of synaptogenesis ISS axon midline choice point recognition ISS positive regulation of axonogenesis IDA homophilic cell adhesion IDA axon guidance receptor activity ISS identical protein binding IDA Roundabout homolog 2; Precursor 10102268 10997877 11404413 15489334 16641997 16829019 17357069 9458045 NA ROBO2 -1 Roundabout homolog 2 Precursor gene 3937 1.0 D - Genome Maintenance aggresome IDA nucleolus IDA mRNA processing IEA transcription termination IEA RNA processing TAS regulation of transcription, DNA-dependent IEA cell growth ISS spermatogenesis IEP DNA catabolic process, exonucleolytic IDA RNA catabolic process TAS 5'-3' exoribonuclease activity TAS zinc ion binding IEA nucleic acid binding IEA 5'-3' exoribonuclease 2; 3.1.13.-; DHM1-like protein; DHP protein 10409438 11230166 11780052 12429849 14702039 15489334 15565158 16147866 16648491 16964243 17081983 17924679 18318008 18669648 18691976 19369195 19690332 20068231 21269460 21406692 NA XRN2 0 5'-3' exoribonuclease 2 3.1.13.- DHM1-like protein DHP protein TF 1291 0.21126419773979 FGFR4 C - Cellular Fate and Organization endoplasmic reticulum IDA integral to plasma membrane IDA extracellular region IEA nucleus IDA endosome IEA insulin receptor signaling pathway TAS positive regulation of cell proliferation IDA protein amino acid autophosphorylation IDA positive regulation of metalloenzyme activity IMP cell migration IMP peptidyl-tyrosine phosphorylation IDA induction of an organ IEA glucose homeostasis ISS positive regulation of proteolysis IMP fibroblast growth factor receptor activity IDA fibroblast growth factor binding IDA ATP binding IEA heparin binding IDA Fibroblast growth factor receptor 4; FGFR-4; 2.7.10.1; CD334; Precursor 10631118 11433297 15340161 15372022 15489334 15863030 16597617 1709094 17311277 17344846 17623664 18480409 18670643 18691976 20018895 20094046 20683963 20798051 20876804 21653700 2247464 7518429 7680645 8663044 9457674 NA FGFR4 -1 Fibroblast growth factor receptor 4 FGFR-4 2.7.10.1 CD334 Precursor gene 1291 0.118412794759788 FGFR2 D - Genome Maintenance Golgi apparatus IEA cell surface IDA integral to plasma membrane IDA cytoplasmic membrane-bound vesicle IEA extracellular region IEA nucleus IDA cell cortex IDA insulin receptor signaling pathway TAS ureteric bud development ISS neuroblast division in the ventricular zone ISS negative regulation of cell proliferation IEA ventricular cardiac muscle morphogenesis ISS cell-cell signaling ISS bone mineralization ISS axonogenesis ISS post-embryonic development ISS pyramidal neuron development ISS hair follicle morphogenesis ISS embryonic pattern specification ISS protein amino acid autophosphorylation IDA body growth ISS neuromuscular junction development IEA organ growth ISS positive regulation of transcription from RNA polymerase II promoter ISS regulation of body size ISS odontogenesis ISS positive regulation of cell division ISS regulation of smooth muscle cell differentiation ISS alveolus development ISS otic vesicle formation ISS apoptosis IEA peptidyl-tyrosine phosphorylation IDA positive regulation of mesenchymal cell proliferation ISS synaptic vesicle transport IEA negative regulation of transcription from RNA polymerase II promoter ISS angiogenesis ISS positive regulation of progression through cell cycle ISS lacrimal gland development ISS negative regulation of mitosis IEA regulation of osteoblast differentiation TAS cell fate commitment ISS regulation of fibroblast growth factor receptor signaling pathway ISS embryonic digestive tract morphogenesis ISS regulation of smoothened signaling pathway ISS midbrain development ISS branching morphogenesis of a nerve ISS fibroblast growth factor receptor activity IDA fibroblast growth factor binding IDA ATP binding IEA heparin binding IEA Fibroblast growth factor receptor 2; FGFR-2; 2.7.10.1; K-sam; KGFR; Keratinocyte growth factor receptor; CD332; Precursor 10196476 10394936 10574673 10618369 10626794 10633130 10712195 10830168 10945669 10951518 11069186 11173845 11380921 11390973 11781872 11856867 12000365 12529371 12591959 1309608 1313574 1400433 14702039 15164054 15190072 15489334 15629145 15863030 16061565 16384934 1647213 16501574 16597617 16844695 16959974 1697263 17311277 17344846 17623664 17803937 18056630 18374639 19060208 19103595 19369195 19387476 19410646 20094046 21454610 21596750 2172978 22387015 2377625 7581378 7655462 7668257 7719333 7719344 7719345 7866434 7874170 7987400 8528214 8644708 8663044 8673103 8676562 8696350 8946174 8956050 8961926 9002682 9150725 9152842 9385368 9452027 9521581 9677057 9693549 9719378 NA FGFR2 -1 Fibroblast growth factor receptor 2 FGFR-2 2.7.10.1 K-sam KGFR Keratinocyte growth factor receptor CD332 Precursor gene 1291 0.0617358293036639 TCF21 C - Cellular Fate and Organization nucleus IDA ureteric bud branching ISS Sertoli cell differentiation ISS alveolus development ISS embryonic digestive tract morphogenesis ISS gland development ISS epithelial cell differentiation ISS palate development ISS spleen development ISS sex determination ISS protein dimerization activity ISS androgen receptor binding ISS Transcription factor 21; TCF-21; Capsulin; Class A basic helix-loop-helix protein 23; bHLHa23; Epicardin; Podocyte-expressed 1; Pod-1 10572052 14574404 15489334 9733105 NA TCF21 -1 Transcription factor 21 TCF-21 Capsulin Class A basic helix-loop-helix protein 23 bHLHa23 Epicardin Podocyte-expressed 1 Pod-1 gene 1291 0.00163900605675009 C - Cellular Fate and Organization cytosol NAS signal transduction NAS metal ion binding IEA SH3 and cysteine-rich domain-containing protein; Src homology 3 and cysteine-rich domain-containing protein 14702039 8954993 NA STAC -1 SH3 and cysteine-rich domain-containing protein Src homology 3 and cysteine-rich domain-containing protein gene 1291 7.37145883925187E-4 DLC1 C - Cellular Fate and Organization caveola IDA nucleus IDA focal adhesion IDA cytosol TAS negative regulation of cell migration IDA negative regulation of cell proliferation IDA actin cytoskeleton organization and biogenesis ISS caspase activation IDA small GTPase mediated signal transduction TAS regulation of cell shape IMP negative regulation of Rho protein signal transduction IMP positive regulation of protein amino acid dephosphorylation IDA neural tube closure ISS induction of apoptosis IDA hindbrain morphogenesis ISS negative regulation of stress fiber formation IDA heart morphogenesis ISS focal adhesion formation ISS forebrain development ISS Rho GTPase activator activity IDA Rho GTPase-activating protein 7; Deleted in liver cancer 1 protein; DLC-1; HP protein; Rho-type GTPase-activating protein 7; START domain-containing protein 12; StARD12; StAR-related lipid transfer protein 12 10649492 11214970 14702039 15489334 16421571 18786931 19158340 19170769 19317456 19710422 9605766 NA RHG07 -1 Rho GTPase-activating protein 7 Deleted in liver cancer 1 protein DLC-1 HP protein Rho-type GTPase-activating protein 7 START domain-containing protein 12 StARD12 StAR-related lipid transfer protein 12 gene 1291 0.0157243800175653 TNS3 C - Cellular Fate and Organization focal adhesion IEA positive regulation of cell proliferation IEA cell migration IEA alveolus development IEA Tensin-3; Tensin-like SH2 domain-containing protein 1; Tumor endothelial marker 6 11230166 11559528 12853948 14702039 15140944 15489334 16461921 17643115 18220336 18669648 20068231 21269460 21406692 NA TENS3 -1 Tensin-3 Tensin-like SH2 domain-containing protein 1 Tumor endothelial marker 6 gene 1291 0.00141353720196018 TNS1 C - Cellular Fate and Organization cytoplasm IEA cytoskeleton IEA focal adhesion IDA cell-substrate junction assembly IEA Tensin-1 11023826 15815621 16959974 17517630 18088087 18220336 18669648 20068231 NA TENS1 -1 Tensin-1 gene 1291 0.0211937638843984 GRHL2 T - Transcription cytoplasm IDA nucleus IDA regulation of transcription, DNA-dependent IEA neural tube closure IEA embryonic development (sensu Mammalia) IEA transcription, DNA-dependent IEA DNA binding IEA Grainyhead-like protein 2 homolog; Brother of mammalian grainyhead; Transcription factor CP2-like 3 12175488 12393799 12549979 14702039 15489334 NA GRHL2 1 Grainyhead-like protein 2 homolog Brother of mammalian grainyhead Transcription factor CP2-like 3 gene 1291 2.86417363433285E-4 CKMT1A C - Cellular Fate and Organization mitochondrial inner membrane TAS creatine metabolic process TAS creatine kinase activity TAS ATP binding IEA Creatine kinase U-type, mitochondrial; 2.7.3.2; Acidic-type mitochondrial creatine kinase; Mia-CK; Ubiquitous mitochondrial creatine kinase; U-MtCK; Precursor 10737943 14702039 15489334 21269460 2914937 NA KCRU 1 Creatine kinase U-type, mitochondrial 2.7.3.2 Acidic-type mitochondrial creatine kinase Mia-CK Ubiquitous mitochondrial creatine kinase U-MtCK Precursor gene 1291 0.0278647230913388 R - Stress and Defence collagen IEA complement component C1q complex TAS inner ear development IEA innate immune response TAS complement activation, classical pathway TAS Complement C1q subcomponent subunit B; Precursor 12960167 15489334 16710414 16959974 3000358 486087 6208566 6286235 6981411 708376 9476130 9777412 NA C1QB 1 Complement C1q subcomponent subunit B Precursor gene 1291 9.22127029133089E-4 SERINC2 N - Not Matched integral to membrane IEA Serine incorporator 2; Tumor differentially expressed protein 2-like 12975309 14702039 15489334 16710414 NA SERC2 1 Serine incorporator 2 Tumor differentially expressed protein 2-like gene 1291 7.91637519637533E-4 A - Transport and Sensing collagen IEA complement component C1q complex TAS innate immune response TAS complement activation, classical pathway TAS cell-cell signaling TAS Complement C1q subcomponent subunit A; Precursor 12960167 14702039 15489334 16335952 16710414 1706597 19159218 486087 6981411 9777412 NA C1QA 1 Complement C1q subcomponent subunit A Precursor gene 1291 0.00724255134674711 D - Genome Maintenance cytoplasm IDA plasma membrane IDA microtubule associated complex TAS microtubule IEA microtubule sliding IMP mitotic spindle organization and biogenesis IMP establishment of spindle orientation IMP cell division IMP structural molecule activity TAS Microtubule-associated protein 4; MAP-4 10791892 14702039 14759258 15144186 15489334 16093351 16641997 16964243 17081983 1718985 17487921 17693683 17924679 17974005 18088087 18669648 1905296 19369195 19690332 20068231 21269460 21406692 7857940 NA MAP4 -1 Microtubule-associated protein 4 MAP-4 gene 1291 8.90961929049651E-6 SERINC1 A - Transport and Sensing plasma membrane ISS endoplasmic reticulum membrane ISS integral to membrane IEA sphingolipid metabolic process ISS positive regulation of transferase activity ISS phospholipid biosynthetic process IEA phosphatidylserine metabolic process ISS L-serine transporter activity ISS Serine incorporator 1; Tumor differentially expressed protein 1-like; Tumor differentially expressed protein 2 10574462 10931946 12975309 14574404 14702039 15489334 17081983 17974005 18669648 19159218 19690332 20213681 NA SERC1 -1 Serine incorporator 1 Tumor differentially expressed protein 1-like Tumor differentially expressed protein 2 gene 1291 0.0816080920104172 NRN1 N - Not Matched cell junction IEA plasma membrane IEA synapse IEA anchored to membrane IEA nervous system development IEA Neuritin; Precursor 14574404 14702039 15489334 9122250 NA NRN1 -1 Neuritin Precursor gene 1291 1.0277442233539E-4 CAPG F - Protein Fate melanosome IEA cytoplasm IDA nuclear membrane IDA nucleolus IDA F-actin capping protein complex TAS barbed-end actin filament capping TAS protein complex assembly NAS cell projection biogenesis IEA Macrophage-capping protein; Actin regulatory protein CAP-G 1322908 15489334 15815621 17081065 19690332 20068231 21269460 7814409 7851883 NA CAPG 1 Macrophage-capping protein Actin regulatory protein CAP-G gene 1291 0.0684467560661034 D - Genome Maintenance cytoplasm ISS nucleus ISS negative regulation of apoptosis ISS ATP metabolic process ISS regulation of cell cycle ISS osteoblast differentiation ISS nucleoside-triphosphatase activity IEA magnesium ion binding ISS hydrolase activity ISS ATP binding IEA Fidgetin-like protein 1; 3.6.4.- 12690205 12853948 14702039 15489334 17974005 19608861 20068231 21269460 NA FIGL1 1 Fidgetin-like protein 1 3.6.4.- gene 1291 0.0449492875329337 PTK6 C - Cellular Fate and Organization cytoplasm IDA plasma membrane IDA nucleus IDA ruffle IDA tyrosine phosphorylation of Stat5 protein IDA tyrosine phosphorylation of Stat3 protein IDA protein amino acid autophosphorylation IMP cell migration IDA negative regulation of growth IEA protein serine/threonine kinase activity IEA non-membrane spanning protein tyrosine kinase activity IDA ATP binding IEA Protein-tyrosine kinase 6; 2.7.10.2; Breast tumor kinase; Tyrosine-protein kinase BRK 10913193 10980601 11780052 12121988 12833144 14702039 15056653 15471878 15489334 15509496 15539407 15572663 15870689 15961400 16179349 16568091 16651629 17344846 17822667 17997837 18296648 18691976 18719096 18829532 19439179 20026641 20193745 21479203 8036022 8940083 9185712 9333026 9749526 NA PTK6 1 Protein-tyrosine kinase 6 2.7.10.2 Breast tumor kinase Tyrosine-protein kinase BRK gene 1291 0.0717638596053337 T - Transcription nucleolus IEA negative regulation of transcription from RNA polymerase II promoter TAS transcription, DNA-dependent IEA transcription corepressor activity TAS zinc ion binding IEA DNA binding IEA Zinc finger protein 593; Zinc finger protein T86 12429849 14702039 15489334 16710414 17081983 18287285 18669648 19690332 20068231 21406692 9115366 NA ZN593 1 Zinc finger protein 593 Zinc finger protein T86 gene 1291 7.02089588150674E-4 D - Genome Maintenance centrosome IEA perikaryon IEA nucleus IEA cell projection IEA cytosol IEA regulation of transcription, DNA-dependent IEA nerve growth factor receptor signaling pathway IEA negative regulation of cell proliferation TAS glial cell migration IEA axon extension involved in development IEA central nervous system development IEA post-embryonic development IEA transcription, DNA-dependent IEA sensory perception of pain IEA nervous system development TAS multicellular organismal homeostasis IEA axonal fasciculation IEA neuron migration IEA regulation of growth IEA DNA binding IEA Necdin 14702039 15489334 21543378 9354807 9630521 NA NECD -1 Necdin gene 1291 6.56952031458719E-4 STARD13 C - Cellular Fate and Organization lipid particle IEA mitochondrial membrane IEA cytosol TAS positive regulation of GTPase activity IEA regulation of small GTPase mediated signal transduction TAS small GTPase mediated signal transduction TAS GTPase activator activity IEA StAR-related lipid transfer protein 13; 46H23.2; Deleted in liver cancer 2 protein; DLC-2; Rho GTPase-activating protein; START domain-containing protein 13; StARD13 12531887 14697242 15057823 15489334 16217026 16364308 17380510 17974005 NA STA13 -1 StAR-related lipid transfer protein 13 46H23.2 Deleted in liver cancer 2 protein DLC-2 Rho GTPase-activating protein START domain-containing protein 13 StARD13 gene 1291 0.00874128630945346 RCC1 D - Genome Maintenance nuclear chromatin IDA condensed nuclear chromosome IDA cytoplasm IDA nuclear membrane IDA nucleoplasm TAS G1/S transition of mitotic cell cycle IMP mitosis IEA regulation of mitosis IDA chromosome segregation IMP viral reproduction TAS mitotic spindle organization and biogenesis IDA regulation of S phase of mitotic cell cycle IMP spindle assembly IMP cell division IEA histone binding IDA nucleosomal DNA binding IDA Ran guanyl-nucleotide exchange factor activity IDA Regulator of chromosome condensation; Cell cycle regulatory protein; Chromosome condensation protein 1 11336674 15489334 16820410 17081983 17435751 1769659 18669648 18762580 1944575 20068231 20668449 21269460 21406692 2236072 3678831 7983178 9510255 NA RCC1 1 Regulator of chromosome condensation Cell cycle regulatory protein Chromosome condensation protein 1 gene 1291 0.0385082947407456 N - Not Matched cytoplasm IDA Schwannomin-interacting protein 1; SCHIP-1 10669747 14702039 15489334 17045569 NA SCHI1 -1 Schwannomin-interacting protein 1 SCHIP-1 gene 1291 0.201795580665838 R - Stress and Defence mitochondrial inner membrane IEA mitochondrial outer membrane TAS integral to membrane IEA positive regulation of dopamine metabolic process IEA response to corticosterone stimulus IEA xenobiotic metabolic process TAS response to drug IEA response to ethanol IEA response to lipopolysaccharide IEA response to toxin IEA response to selenium ion IEA response to aluminum ion IEA negative regulation of serotonin secretion IEA amine oxidase activity TAS FAD binding IEA electron carrier activity TAS Amine oxidase [flavin-containing] B; 1.4.3.4; Monoamine oxidase type B; MAO-B 11049757 11753429 12913124 1432104 14702039 15027868 15710600 15772651 16366596 2023912 3387449 8316221 8515265 8665924 NA AOFB -1 Amine oxidase [flavin-containing] B 1.4.3.4 Monoamine oxidase type B MAO-B gene 1291 0.166801148888521 APH1A C - Cellular Fate and Organization Golgi apparatus IDA endoplasmic reticulum IDA integral to plasma membrane IDA endoplasmic reticulum membrane IEA integral to membrane IEA metanephros development IEA amyloid precursor protein catabolic process IMP nerve growth factor receptor signaling pathway TAS Notch receptor processing IMP Notch signaling pathway TAS protein processing IDA membrane protein intracellular domain proteolysis IMP apoptosis TAS membrane protein ectodomain proteolysis IDA positive regulation of enzyme activity IDA endopeptidase activity IEA Gamma-secretase subunit APH-1A; APH-1a; Aph-1alpha; Presenilin-stabilization factor 10810093 12110170 12297508 12471034 12522139 12679784 12740439 12763021 12975309 14593096 14702039 15489334 16710414 NA APH1A 1 Gamma-secretase subunit APH-1A APH-1a Aph-1alpha Presenilin-stabilization factor gene 1291 0.0108332369209013 FAF2 F - Protein Fate lipid particle IDA response to unfolded protein IEA ubiquitin binding IDA ubiquitin protein ligase binding IDA FAS-associated factor 2; Protein ETEA; UBX domain-containing protein 3B; UBX domain-containing protein 8 10048485 12372427 15489334 18711132 19608861 19773358 19818707 21269460 NA FAF2 1 FAS-associated factor 2 Protein ETEA UBX domain-containing protein 3B UBX domain-containing protein 8 gene 1291 8.71248705947511E-4 SACM1L C - Cellular Fate and Organization Golgi membrane TAS endoplasmic reticulum membrane ISS integral to endoplasmic reticulum membrane IEA phosphatidylinositol biosynthetic process TAS phosphoinositide dephosphorylation IEA phosphoric monoester hydrolase activity ISS phosphatidylinositol-3-phosphatase activity IEA Phosphatidylinositide phosphatase SAC1; 3.1.3.-; Suppressor of actin mutations 1-like protein 10048485 11230166 11352561 14702039 15489334 19608861 21269460 NA SAC1 -1 Phosphatidylinositide phosphatase SAC1 3.1.3.- Suppressor of actin mutations 1-like protein gene 1291 0.0178778291877126 C - Cellular Fate and Organization extracellular matrix (sensu Metazoa) IEA extracellular space IDA negative regulation of cell proliferation IEA collagen fibril organization IEA cell adhesion IEA Dermatopontin; Tyrosine-rich acidic matrix protein; TRAMP; Precursor 10233760 14702039 15489334 16710414 8104875 NA DERM -1 Dermatopontin Tyrosine-rich acidic matrix protein TRAMP Precursor gene 1291 0.0236291681255976 AK2 C - Cellular Fate and Organization mitochondrial intermembrane space TAS mitochondrial inner membrane IEA cytosol IEA liver development IEA AMP metabolic process IEA nucleobase, nucleoside and nucleotide interconversion TAS ATP metabolic process IEA dATP metabolic process IEA brain development IEA ADP biosynthetic process IEA oxidative phosphorylation IEA adenylate kinase activity TAS ATP binding IEA Adenylate kinase 2, mitochondrial; AK 2; 2.7.4.3; ATP-AMP transphosphorylase 2 14702039 15489334 16710414 19043416 19043417 19054851 21269460 8843353 9434148 9504408 NA KAD2 1 Adenylate kinase 2, mitochondrial AK 2 2.7.4.3 ATP-AMP transphosphorylase 2 gene 1291 0.0240272120400372 C - Cellular Fate and Organization cytoplasmic membrane-bound vesicle IEA cytoplasmic vesicle IDA early endosome IDA positive regulation of GTPase activity IEA signal transduction IEA endocytosis NAS Rab guanyl-nucleotide exchange factor activity IMP Rab GTPase binding IDA GTPase activator activity IEA Ras and Rab interactor 3; Ras interaction/interference protein 3 11733506 12508121 12972505 14702039 15489334 18486601 21586568 NA RIN3 -1 Ras and Rab interactor 3 Ras interaction/interference protein 3 gene 1291 0.00602036665382763 RIN2 C - Cellular Fate and Organization cytoplasm IEA positive regulation of GTPase activity IEA small GTPase mediated signal transduction NAS endocytosis IEA Rab guanyl-nucleotide exchange factor activity NAS GTPase activator activity IEA Ras and Rab interactor 2; Ras association domain family 4; Ras inhibitor JC265; Ras interaction/interference protein 2 11230166 11733506 11780052 14702039 18318008 1849280 19631308 NA RIN2 -1 Ras and Rab interactor 2 Ras association domain family 4 Ras inhibitor JC265 Ras interaction/interference protein 2 gene 1291 0.171241071829117 PPARG C - Cellular Fate and Organization nucleoplasm TAS cytosol ISS lipid metabolic process TAS negative regulation of telomerase activity IEA response to estrogen stimulus IEA negative regulation of cell growth IEA transcription initiation from RNA polymerase II promoter TAS organ regeneration IEA response to cold IEA heart development IEA lipoprotein transport IDA positive regulation of transcription factor activity IDA response to caffeine IEA positive regulation of transcription from RNA polymerase II promoter IDA epithelial cell differentiation ISS cell maturation IDA monocyte differentiation IDA fatty acid oxidation IEA low-density lipoprotein receptor biosynthetic process IDA response to nutrient TAS caspase activation IDA response to drug IEA positive regulation of fatty acid oxidation IEA negative regulation of smooth muscle cell proliferation IDA placenta development ISS negative regulation of transcription from RNA polymerase II promoter IDA glucose homeostasis IMP induction of apoptosis IDA negative regulation of acute inflammatory response IEA cell fate commitment ISS white fat cell differentiation TAS brown fat cell differentiation IEA innate immune response TAS positive regulation of oligodendrocyte differentiation IEA positive regulation of fat cell differentiation ISS blood pressure regulation IMP long-chain fatty acid transport ISS sequence-specific DNA binding IEA retinoid X receptor binding IDA ligand-dependent nuclear receptor transcription coactivator activity IDA arachidonic acid binding ISS chromatin binding IEA drug binding IDA steroid hormone receptor activity IEA zinc ion binding IEA ligand-dependent nuclear receptor activity IDA prostaglandin receptor activity TAS Peroxisome proliferator-activated receptor gamma; PPAR-gamma; Nuclear receptor subfamily 1 group C member 3 10394368 10407229 10523018 10622252 10681503 10851250 10882139 11587644 11698662 11788685 11971969 12039952 12453919 12672231 14569127 14702039 15047147 15056000 15258145 15356014 15489334 15562396 15687259 15974597 15976031 16150867 16239304 16451087 16640330 16641997 16842753 16919947 17101779 20829347 21047783 7787419 8702406 8706692 9065481 9144532 9356045 9425261 9744270 9753710 9806549 9813012 NA PPARG -1 Peroxisome proliferator-activated receptor gamma PPAR-gamma Nuclear receptor subfamily 1 group C member 3 gene 4174 1.0 PPARD C - Cellular Fate and Organization nucleoplasm TAS keratinocyte migration IEA positive regulation of cell proliferation IEA transcription initiation from RNA polymerase II promoter TAS cell proliferation ISS anagen IEA negative regulation of epithelial cell proliferation IEA generation of precursor metabolites and energy TAS axon ensheathment ISS cell differentiation IEA decidualization TAS glucose transport NAS glucose metabolic process NAS cholesterol metabolic process TAS fatty acid beta-oxidation ISS embryo implantation TAS cell-substrate adhesion IEA apoptosis IMP positive regulation of phosphoinositide 3-kinase cascade IEA negative regulation of transcription from RNA polymerase II promoter ISS keratinocyte proliferation IEA wound healing IEA positive regulation of fat cell differentiation NAS fatty acid transport ISS positive regulation of transcription, DNA-dependent IDA sequence-specific DNA binding IEA drug binding IDA steroid hormone receptor activity TAS zinc ion binding IEA ligand-dependent nuclear receptor activity IDA DNA binding ISS Peroxisome proliferator-activated receptor delta; PPAR-delta; NUCI; Nuclear hormone receptor 1; NUC1; Nuclear receptor subfamily 1 group C member 2; Peroxisome proliferator-activated receptor beta; PPAR-beta 10198642 10809235 10851270 1333051 14574404 14702039 15489334 15604518 16387648 16405912 16931011 17560785 18619963 18722772 19116277 19464171 19622862 NA PPARD 0 Peroxisome proliferator-activated receptor delta PPAR-delta NUCI Nuclear hormone receptor 1 NUC1 Nuclear receptor subfamily 1 group C member 2 Peroxisome proliferator-activated receptor beta PPAR-beta TF 1291 0.0714360801321983 REV3L D - Genome Maintenance chromosome IBA nucleus IBA zeta DNA polymerase complex IDA DNA-dependent DNA replication TAS bypass DNA synthesis IBA 4 iron, 4 sulfur cluster binding IEA nucleotide binding IEA DNA-directed DNA polymerase activity IBA DNA binding IEA metal ion binding IEA DNA polymerase zeta catalytic subunit; 2.7.7.7; Protein reversionless 3-like; REV3-like; hREV3 10102035 10660610 14574404 19690332 20164194 9618506 9925914 NA DPOLZ -1 DNA polymerase zeta catalytic subunit 2.7.7.7 Protein reversionless 3-like REV3-like hREV3 gene 1291 0.341099895440387 MYADM N - Not Matched integral to membrane IEA Myeloid-associated differentiation marker; Protein SB135 12075932 12975309 14702039 15489334 16303743 18669648 19690332 NA MYADM -1 Myeloid-associated differentiation marker Protein SB135 gene 1291 0.0979480891694494 F2RL1 C - Cellular Fate and Organization Golgi apparatus TAS integral to plasma membrane IDA pseudopodium ISS interleukin-1 beta secretion IDA positive regulation of eosinophil degranulation IDA positive regulation of Rho protein signal transduction IMP positive regulation of JNK cascade IDA positive regulation of phosphoinositide 3-kinase cascade ISS leukocyte migration IDA elevation of cytosolic calcium ion concentration IDA positive regulation of leukocyte chemotaxis IDA positive regulation of positive chemotaxis IDA defense response to virus IDA negative regulation of JNK cascade IDA positive regulation of cytokine secretion during immune response IDA inflammatory response IEA regulation of blood coagulation IDA blood coagulation IEA positive regulation of actin filament depolymerization IDA innate immune response IEA positive regulation of vasodilation ISS positive regulation of transcription from RNA polymerase II promoter IDA positive regulation of pseudopodium formation ISS neutrophil activation IDA positive regulation of I-kappaB kinase/NF-kappaB cascade IDA T cell activation during immune response ISS G-protein alpha-subunit binding ISS G-protein beta-subunit binding ISS G-protein coupled receptor activity IMP thrombin receptor activity IEA receptor binding TAS Proteinase-activated receptor 2; PAR-2; Coagulation factor II receptor-like 1; G-protein coupled receptor 11; Thrombin receptor-like 1; Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate cleaved 2; Precursor 10086357 10725339 10788464 10805786 10831593 11413129 11441110 11447194 11714832 11859856 12171601 12594060 12832443 14519665 14607272 15155775 15489334 15708858 15879675 15919826 16359518 16410250 16476770 16478888 16714334 17404307 17500066 17693410 18424071 18453611 18474671 18622013 19494303 19684015 19781631 19815543 19864598 19865078 20530726 20584806 20826780 21501162 21627585 7556175 8615752 8784787 9020112 NA PAR2 1 Proteinase-activated receptor 2 PAR-2 Coagulation factor II receptor-like 1 G-protein coupled receptor 11 Thrombin receptor-like 1 Proteinase-activated receptor 2, alternate cleaved 1 Proteinase-activated receptor 2, alternate cleaved 2 Precursor gene 1291 0.0117275879781976 DPY19L1 N - Not Matched integral to membrane IEA Protein dpy-19 homolog 1; Dpy-19-like protein 1 10048485 15489334 16526957 NA D19L1 1 Protein dpy-19 homolog 1 Dpy-19-like protein 1 gene 1291 0.0902558525606445 LIN7A F - Protein Fate basolateral plasma membrane IEA postsynaptic membrane IEA postsynaptic density IEA tight junction IEA inner ear development IEA protein complex assembly TAS synaptic vesicle transport IEA exocytosis TAS protein transport IEA neurotransmitter secretion IEA Protein lin-7 homolog A; Lin-7A; hLin-7; Mammalian lin-seven protein 1; MALS-1; Tax interaction protein 33; TIP-33; Vertebrate lin-7 homolog 1; Veli-1 10341223 11311936 12967566 14702039 15489334 17237226 9482110 9753324 NA LIN7A -1 Protein lin-7 homolog A Lin-7A hLin-7 Mammalian lin-seven protein 1 MALS-1 Tax interaction protein 33 TIP-33 Vertebrate lin-7 homolog 1 Veli-1 gene 1291 0.162830200325742 TTC28 Tetratricopeptide repeat protein 28; TPR repeat protein 28 10470851 10591208 12168954 15489334 17974005 18669648 18691976 19369195 20068231 21269460 NA TTC28 -1 Tetratricopeptide repeat protein 28 TPR repeat protein 28 gene 1394 0.157678612058417 ZNF217 T - Transcription histone deacetylase complex IDA negative regulation of transcription, DNA-dependent IDA transcription, DNA-dependent TAS transcription factor activity TAS zinc ion binding IEA Zinc finger protein 217 11780052 12493763 15489334 16203743 16940172 16959974 17259635 18625718 18669648 21406692 9671742 NA ZN217 1 Zinc finger protein 217 TF 1291 0.00190723864225319 FADD C - Cellular Fate and Organization neuron projection IEA CD95 death-inducing signaling complex IDA lipid raft IEA cytosol TAS induction of apoptosis via death domain receptors TAS defense response to virus IMP positive regulation of apoptosis IMP positive regulation of tumor necrosis factor-alpha production IDA caspase activation TAS virus-host interaction IEA innate immune response TAS positive regulation of transcription from RNA polymerase II promoter IDA positive regulation of I-kappaB kinase/NF-kappaB cascade IEP protein heterooligomerization IEA positive regulation of interleukin-8 production IDA death receptor binding TAS Protein FADD; FAS-associated death domain protein; FAS-associating death domain-containing protein; Growth-inhibiting gene 3 protein; Mediator of receptor induced toxicity 10442631 10825539 10964568 11034606 12702765 14702039 15489334 16127453 16762833 19118384 19690332 20068231 20935634 21109225 21269460 21406692 7536190 7538907 9582077 NA FADD 1 Protein FADD FAS-associated death domain protein FAS-associating death domain-containing protein Growth-inhibiting gene 3 protein Mediator of receptor induced toxicity gene 1291 0.00238951736395554 FILIP1 Filamin-A-interacting protein 1; FILIP 10574462 14574404 14702039 15489334 17974005 NA FLIP1 -1 Filamin-A-interacting protein 1 FILIP gene 1291 0.283263917962596 CTSO F - Protein Fate lysosome IEA proteolysis TAS cysteine-type endopeptidase activity TAS Cathepsin O; 3.4.22.42; Precursor 15489334 7929457 NA CATO -1 Cathepsin O 3.4.22.42 Precursor gene 1291 0.0102537096076595 ATP1A2 M - Other Metabolism cytoplasm IDA dendritic spine IEA caveola IEA synapse IEA T-tubule IEA sodium:potassium-exchanging ATPase complex IC endosome IEA adult locomotory behavior IEA reduction of cytosolic calcium ion concentration IEA regulation of striated muscle contraction NAS regulation of smooth muscle contraction IEA regulation of vasoconstriction IEA locomotion IEA neurological control of breathing IEA ATP biosynthetic process IEA cardiac inotropy IEA negative regulation of striated muscle contraction IEA visual learning IEA neurotransmitter uptake IEA ATP hydrolysis coupled proton transport IEA blood pressure regulation IEA negative regulation of heart contraction IEA response to nicotine IEA ATP binding IEA metal ion binding IEA sodium:potassium-exchanging ATPase activity IMP Sodium/potassium-transporting ATPase subunit alpha-2; Na(+)/K(+) ATPase alpha-2 subunit; 3.6.3.9; Sodium pump subunit alpha-2; Precursor 12539047 12953268 15174025 15489334 16710414 18669648 21352219 2477373 2537767 3035563 3036582 7711835 9872452 NA AT1A2 -1 Sodium/potassium-transporting ATPase subunit alpha-2 Na(+)/K(+) ATPase alpha-2 subunit 3.6.3.9 Sodium pump subunit alpha-2 Precursor gene 1291 0.00550844870783072 PDXDC1 N - Not Matched carboxylic acid metabolic process IEA pyridoxal phosphate binding IEA carboxy-lyase activity IEA Pyridoxal-dependent decarboxylase domain-containing protein 1; 4.1.1.- 15489334 16964243 17081983 18669648 20068231 21269460 21406692 9039502 NA PDXD1 1 Pyridoxal-dependent decarboxylase domain-containing protein 1 4.1.1.- gene 1291 0.202472439974357 SULF1 C - Cellular Fate and Organization Golgi apparatus ISS Golgi stack IEA plasma membrane ISS cell surface IDA endoplasmic reticulum IDA lipid raft IDA extracellular space IDA positive regulation of BMP signaling pathway IMP vascular endothelial growth factor receptor signaling pathway IDA negative regulation of cell migration IMP chondrocyte development ISS negative regulation of endothelial cell proliferation IDA negative regulation of angiogenesis IDA negative regulation of fibroblast growth factor receptor signaling pathway IMP embryonic skeletal development ISS apoptosis IEA positive regulation of Wnt receptor signaling pathway IDA glomerular basement membrane development ISS heparan sulfate proteoglycan metabolic process IDA calcium ion binding IEA arylsulfatase activity IDA N-acetylglucosamine-6-sulfatase activity IDA Extracellular sulfatase Sulf-1; hSulf-1; 3.1.6.-; Precursor 10470851 12368295 12686563 14702039 19159218 NA SULF1 1 Extracellular sulfatase Sulf-1 hSulf-1 3.1.6.- Precursor gene 1291 0.0555521932186291 MYH11 M - Other Metabolism melanosome IEA stress fiber IEA muscle myosin complex TAS cytosol TAS smooth muscle contractile fiber IEA smooth muscle contraction ISS cardiac muscle fiber development IMP axon guidance TAS muscle thick filament assembly ISS elastic fiber assembly IMP motor activity IEA structural constituent of muscle IMP ATP binding IEA Myosin-11; Myosin heavy chain 11; Myosin heavy chain, smooth muscle isoform; SMMHC 10048485 10493829 15489334 15616553 16000639 16444274 17081065 18318008 7684189 NA MYH11 -1 Myosin-11 Myosin heavy chain 11 Myosin heavy chain, smooth muscle isoform SMMHC gene 6527 1.0 C - Cellular Fate and Organization nuclear chromatin IEA nucleus IDA cytosol TAS signal transduction TAS negative regulation of T-helper 2 type immune response IEA regulation of transcription from RNA polymerase II promoter TAS positive regulation of isotype switching to IgE isotypes IEA regulation of cell proliferation IEA positive regulation of transcription from RNA polymerase II promoter IEA cytokine and chemokine mediated signaling pathway IEA negative regulation of transcription from RNA polymerase II promoter IEA T-helper 1 cell lineage commitment IEA transcription, DNA-dependent IEA transcription factor activity TAS calcium ion binding IEA signal transducer activity IEA Signal transducer and activator of transcription 6; IL-4 Stat 12138096 14702039 14757047 15489334 16541075 8085155 9782085 NA STAT6 0 Signal transducer and activator of transcription 6 IL-4 Stat TF 1291 0.183994147238444 RAPGEF5 C - Cellular Fate and Organization nucleus IDA regulation of small GTPase mediated signal transduction IEA small GTPase mediated signal transduction NAS nervous system development NAS Rap guanyl-nucleotide exchange factor activity IDA Rap guanine nucleotide exchange factor 5; Guanine nucleotide exchange factor for Rap1; M-Ras-regulated Rap GEF; MR-GEF; Related to Epac; Repac 10486569 10777494 10934204 12690205 15489334 9039502 NA RPGF5 -1 Rap guanine nucleotide exchange factor 5 Guanine nucleotide exchange factor for Rap1 M-Ras-regulated Rap GEF MR-GEF Related to Epac Repac gene 1291 0.00964032494266694 D - Genome Maintenance axon IEA stress fiber IDA neuromuscular junction IEA plasma membrane IEA spindle IEA midbody IDA myosin complex IEA cleavage furrow IDA growth cone IEA dendritic spine IEA cell soma IEA myosin II complex IEA cell cortex IDA actin filament-based movement IDA cytokinesis after mitosis IDA cell proliferation IEA nuclear migration IEA regulation of cell shape IEA exocytosis IEA embryonic development (sensu Mammalia) IEA third ventricle development IEA adult heart development IEA substrate-bound cell migration, cell extension IEA lateral ventricle development IEA cerebellar Purkinje cell layer development IEA axon guidance TAS fourth ventricle development IEA regulation of balance IEA ventricular cardiac muscle cell development IEA plasma membrane repair IEA cardiac myofibril assembly IEA neuron migration IEA microfilament motor activity IDA motor activity IEA actin filament binding IDA ADP binding IDA ATP binding IEA actin-dependent ATPase activity IDA Myosin-10; Cellular myosin heavy chain, type B; Myosin heavy chain 10; Myosin heavy chain, non-muscle IIb; Non-muscle myosin heavy chain B; NMMHC-B; Non-muscle myosin heavy chain IIb; NMMHC II-b; NMMHC-IIB 15489334 16625196 16721066 17081983 17525332 18318008 1860190 18669648 19608861 19690332 20068231 20603131 20682791 21269460 21406692 7499478 7782316 7916668 8690889 NA MYH10 -1 Myosin-10 Cellular myosin heavy chain, type B Myosin heavy chain 10 Myosin heavy chain, non-muscle IIb Non-muscle myosin heavy chain B NMMHC-B Non-muscle myosin heavy chain IIb NMMHC II-b NMMHC-IIB gene 1291 0.00278859755477853 RAPGEF4 C - Cellular Fate and Organization cAMP-dependent protein kinase complex IEA plasma membrane TAS cytosol IEA regulation of small GTPase mediated signal transduction IEA energy reserve metabolic process TAS G-protein coupled receptor protein signaling pathway TAS regulation of insulin secretion TAS small GTPase mediated signal transduction IEA calcium ion-dependent exocytosis IEA regulation of exocytosis IEA cAMP-mediated signaling IEA platelet activation TAS insulin secretion IEA cAMP binding ISS cAMP-dependent protein kinase regulator activity IEA Ras GTPase binding ISS Ras guanyl-nucleotide exchange factor activity ISS Rap guanine nucleotide exchange factor 4; Exchange factor directly activated by cAMP 2; Exchange protein directly activated by cAMP 2; EPAC 2; cAMP-regulated guanine nucleotide exchange factor II; cAMP-GEFII 10777494 11707077 14702039 15489334 9856955 NA RPGF4 -1 Rap guanine nucleotide exchange factor 4 Exchange factor directly activated by cAMP 2 Exchange protein directly activated by cAMP 2 EPAC 2 cAMP-regulated guanine nucleotide exchange factor II cAMP-GEFII gene 1291 0.00429830845076463 CTSA F - Protein Fate mitochondrion IEA endoplasmic reticulum TAS nucleus IDA lysosomal lumen TAS glycosphingolipid metabolic process TAS proteolysis IEA phospholipid metabolic process TAS intracellular protein transport TAS serine carboxypeptidase activity IEA carboxypeptidase activity TAS enzyme activator activity TAS Lysosomal protective protein; 3.4.16.5; Carboxypeptidase C; Carboxypeptidase L; Cathepsin A; Protective protein cathepsin A; PPCA; Protective protein for beta-galactosidase; Lysosomal protective protein 32 kDa chain; Lysosomal protective protein 20 kDa chain; Precursor 10944848 11780052 12665801 14702039 15489334 16263699 1694176 1756715 1907282 19159218 21269460 3136930 8514852 8591035 8968752 NA PPGB 1 Lysosomal protective protein 3.4.16.5 Carboxypeptidase C Carboxypeptidase L Cathepsin A Protective protein cathepsin A PPCA Protective protein for beta-galactosidase Lysosomal protective protein 32 kDa chain Lysosomal protective protein 20 kDa chain Precursor gene 3032 1.0 STAT3 C - Cellular Fate and Organization plasma membrane ISS nucleoplasm TAS cytosol TAS eye photoreceptor cell differentiation ISS positive regulation of Notch signaling pathway ISS nerve growth factor receptor signaling pathway TAS thermoregulation ISS cell proliferation IEA response to drug IEA response to ethanol IEA astrocyte differentiation ISS cell motility TAS acute-phase response IEA negative regulation of transcription from RNA polymerase II promoter TAS glucose homeostasis ISS protein import into nucleus IDA sexual reproduction ISS radial glial cell differentiation ISS positive regulation of transcription from RNA polymerase II promoter IDA virus-host interaction IEA stem cell maintenance IEA regulation of body size IEA eating behavior ISS response to estradiol stimulus IDA sequence-specific DNA binding IEA protein kinase binding ISS calcium ion binding IEA protein dimerization activity ISS ligand-dependent nuclear receptor activity IDA Signal transducer and activator of transcription 3; Acute-phase response factor 10688651 11773079 12023369 12208879 12763138 12873986 14702039 15194700 15465816 15467733 15489334 15526160 15592455 15677474 15919823 15994929 16219639 16568091 17676033 17875724 17881745 17956865 18070987 18234692 18599021 18669648 18691976 19147545 20068231 20826784 21135090 21269460 7512451 7701321 9388184 9630560 NA STAT3 0 Signal transducer and activator of transcription 3 Acute-phase response factor TF 1291 1.20641378599824E-4 RAPGEF2 C - Cellular Fate and Organization intracellular IEA integral to plasma membrane NAS MAPKKK cascade NAS small GTPase mediated signal transduction TAS regulation of synaptic plasticity ISS cAMP-mediated signaling NAS Rap GTPase activator activity IDA calcium ion binding NAS signal transducer activity TAS Rap guanyl-nucleotide exchange factor activity IDA diacylglycerol binding NAS Rap guanine nucleotide exchange factor 2; Neural RAP guanine nucleotide exchange protein; nRap GEP; PDZ domain-containing guanine nucleotide exchange factor 1; PDZ-GEF1; RA-GEF 10548487 10608883 10934204 17081983 17525332 18088087 18669648 19690332 20068231 21269460 9205841 NA RPGF2 -1 Rap guanine nucleotide exchange factor 2 Neural RAP guanine nucleotide exchange protein nRap GEP PDZ domain-containing guanine nucleotide exchange factor 1 PDZ-GEF1 RA-GEF gene 1291 1.0 T - Transcription plasma membrane IDA nucleoplasm TAS cytosol TAS defense response to virus IEA regulation of transcription from RNA polymerase II promoter TAS virus-host interaction IEA JAK-STAT cascade TAS transcription, DNA-dependent IEA transcription factor activity IEA calcium ion binding IEA signal transducer activity TAS DNA binding IEA Signal transducer and activator of transcription 2; p113 10702714 11150296 12509459 1502204 15489334 16227264 1638633 18701593 19279106 19754307 21269460 7532278 7885841 8601453 9020188 9121453 NA STAT2 0 Signal transducer and activator of transcription 2 p113 TF 1875 1.0 C - Cellular Fate and Organization axon ISS nuclear chromatin IDA nucleolus IDA nucleoplasm TAS dendrite ISS cytosol TAS circulation ISS positive regulation of mesenchymal cell proliferation ISS induction of apoptosis ISS negative regulation of transcription from RNA polymerase II promoter ISS response to cAMP ISS positive regulation of smooth muscle cell proliferation ISS defense response to virus IEA negative regulation of endothelial cell proliferation IMP positive regulation of transcription from RNA polymerase II promoter IDA virus-host interaction IEA negative regulation of angiogenesis IMP response to exogenous dsRNA IEA lipopolysaccharide-mediated signaling pathway IEA negative regulation of I-kappaB kinase/NF-kappaB cascade IMP transcription factor activity IDA double-stranded DNA binding IDA calcium ion binding IEA signal transducer activity IEA protein homodimerization activity IDA Signal transducer and activator of transcription 1-alpha/beta; Transcription factor ISGF-3 components p91/p84 10702714 11278462 11442634 11452125 12590259 12764129 12855578 14702039 1502203 15140960 15322115 15489334 15526160 15815621 15825084 16139798 1638633 16934001 16959974 17311277 17561467 17897103 17974005 18669648 18691976 18721752 19088846 19136629 19690332 20068231 20841510 21135090 21269460 21714643 21727188 22573496 7543024 7657660 7885841 8605877 9121453 9630226 9724754 NA STAT1 0 Signal transducer and activator of transcription 1-alpha/beta Transcription factor ISGF-3 components p91/p84 TF 1293 1.0 AHR D - Genome Maintenance transcription factor complex TAS cell cycle TAS xenobiotic metabolic process TAS blood vessel development NAS positive regulation of transcriptional preinitiation complex formation IEA response to stress IDA apoptosis TAS regulation of B cell proliferation IDA prostate gland development IEA negative regulation of transcription from RNA polymerase II promoter IEA sequence-specific DNA binding IEA protein heterodimerization activity TAS RNA polymerase II transcription factor activity, enhancer binding IEA Hsp90 protein binding IDA ligand-dependent nuclear receptor activity IDA Aryl hydrocarbon receptor; Ah receptor; AhR; Class E basic helix-loop-helix protein 76; bHLHe76; Precursor 10395741 10739168 11259615 11689007 11698344 12213388 12213390 12215427 12690205 12853948 15489334 16582008 16696038 7515333 7550366 7883760 7961644 8246913 8393992 NA AHR 0 Aryl hydrocarbon receptor Ah receptor AhR Class E basic helix-loop-helix protein 76 bHLHe76 Precursor TF 1291 0.154619333409719 TNFRSF21 C - Cellular Fate and Organization axon IEA cytoplasm IDA plasma membrane TAS integral to membrane IEA signal transduction IEA neuron apoptosis IEA cellular lipid metabolic process TAS Tumor necrosis factor receptor superfamily member 21; Death receptor 6; CD358; Precursor 12975309 14574404 14702039 15489334 9714541 NA TNR21 1 Tumor necrosis factor receptor superfamily member 21 Death receptor 6 CD358 Precursor gene 1291 3.25413269412582E-4 D - Genome Maintenance nucleoplasm TAS cytosol TAS S phase of mitotic cell cycle TAS DNA replication IEA G1/S-specific transcription in mitotic cell cycle TAS regulation of DNA replication initiation IDA DNA replication checkpoint IDA M/G1 transition of mitotic cell cycle TAS regulation of S phase of mitotic cell cycle IEA DNA binding ISS DNA replication factor Cdt1; Double parked homolog; DUP 10766248 11125146 14672932 14993212 15257290 15489334 15616553 16861906 16949367 17085480 18669648 19690332 21358631 21358632 21543332 21856198 NA CDT1 1 DNA replication factor Cdt1 Double parked homolog DUP gene 1291 0.162830200325742 N - Not Matched integral to membrane IEA PQ-loop repeat-containing protein 1 14702039 15489334 16959974 NA PQLC1 -1 PQ-loop repeat-containing protein 1 gene 1291 0.00224379899444303 N - Not Matched extracellular space TAS chitin catabolic process IEA carbohydrate metabolic process IEA chitin binding IDA cation binding IEA hydrolase activity, hydrolyzing O-glycosyl compounds IEA Chitinase-3-like protein 2; Chondrocyte protein 39; YKL-39; Precursor 14702039 15489334 16710414 22742450 8702629 NA CH3L2 -1 Chitinase-3-like protein 2 Chondrocyte protein 39 YKL-39 Precursor gene 1291 0.00685925996823963 TXNDC17 N - Not Matched cytosol IDA peroxidase activity IDA electron carrier activity IDA protein-disulfide reductase activity IDA Thioredoxin domain-containing protein 17; 14 kDa thioredoxin-related protein; TRP14; Protein 42-9-9; Thioredoxin-like protein 5 14607843 14607844 14702039 15355959 15489334 21269460 NA TXD17 1 Thioredoxin domain-containing protein 17 14 kDa thioredoxin-related protein TRP14 Protein 42-9-9 Thioredoxin-like protein 5 gene 1291 0.024546100231356 C - Cellular Fate and Organization stress fiber IDA cytoplasm IDA cell-cell adherens junction IDA integral to plasma membrane TAS nucleus IEA focal adhesion IDA signal transduction TAS virus-host interaction IEA cell-cell signaling TAS cell adhesion TAS zinc ion binding IEA Zyxin; Zyxin-2 10801818 11689660 12690205 12695497 12853948 15489334 16964243 17081983 17924679 18088087 18158903 18220336 18297730 18669648 19608861 19690332 20068231 21269460 21406692 8917469 8940160 NA ZYX -1 Zyxin Zyxin-2 gene 1291 6.70900233782731E-4 SHARPIN C - Cellular Fate and Organization postsynaptic density IEA cytosol IDA apoptotic nuclear changes IEA brain development IEA negative regulation of inflammatory response ISS keratinization IEA protein homooligomerization IEA mitochondrion organization and biogenesis IEA positive regulation of I-kappaB kinase/NF-kappaB cascade IDA zinc ion binding IEA polyubiquitin binding IDA Sharpin; Shank-associated RH domain-interacting protein; Shank-interacting protein-like 1; hSIPL1 11230166 12753155 14702039 15489334 16421571 18669648 20068231 20179993 21455173 21455180 21455181 22549881 NA SHRPN 1 Sharpin Shank-associated RH domain-interacting protein Shank-interacting protein-like 1 hSIPL1 gene 1507 0.0445476935312808 TNFRSF1B C - Cellular Fate and Organization perinuclear region IEA plasma membrane IEA varicosity IEA cell soma IEA extracellular region IEA nucleus IEA lipid raft IDA integral to membrane IEA immune response IEA RNA destabilization IEA positive regulation of membrane protein ectodomain proteolysis IMP inflammatory response IEA negative regulation of inflammatory response IEA apoptosis IEA tumor necrosis factor receptor activity TAS Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; TNF-RII; TNFR-II; p75; p80 TNF-alpha receptor; CD120b; Etanercept; Tumor necrosis factor receptor superfamily member 1b, membrane form; Tumor necrosis factor-binding protein 2; TBP-2; TBPII; Precursor 10206649 11197692 11762942 12161545 12370298 1328224 14688072 15489334 16710414 1966549 2153136 2160731 2166946 2172983 2173696 8015639 8069916 8661109 NA TNR1B -1 Tumor necrosis factor receptor superfamily member 1B Tumor necrosis factor receptor 2 TNF-R2 Tumor necrosis factor receptor type II TNF-RII TNFR-II p75 p80 TNF-alpha receptor CD120b Etanercept Tumor necrosis factor receptor superfamily member 1b, membrane form Tumor necrosis factor-binding protein 2 TBP-2 TBPII Precursor gene 1624 1.0 T - Transcription cytoplasm ISS nuclear speck IDA nucleolus IEA nucleoplasm IDA negative regulation of protein biosynthetic process IDA RNA splicing ISS negative regulation of cell growth IDA ureteric bud branching IGI negative regulation of apoptosis IGI thorax and anterior abdomen determination ISS induction of apoptosis IDA negative regulation of transcription from RNA polymerase II promoter IDA glomerular basement membrane development IMP germ cell development ISS sex determination IDA male genitalia development ISS eye development (sensu Vertebrata) ISS positive regulation of transcription, DNA-dependent IDA negative regulation of transcription, DNA-dependent IDA vasculogenesis ISS male gonad development IEP sequence-specific DNA binding IDA RNA binding IEA zinc ion binding IDA Wilms tumor protein; WT33 10571943 10738002 10799199 11001926 11182928 11519891 12239212 12970737 1302008 1313285 1317572 1338906 14702039 15150775 15253707 15266301 15349765 15489334 15518539 15520190 1572653 1654525 1655284 16554811 1658787 1671709 16934801 17361230 17716689 17853480 19123921 19416806 2154335 2154702 7862533 7926762 8111391 8112732 8295405 8388765 8393820 8401592 8411073 8621495 8741319 8956030 9108089 9475094 9529364 9607189 NA WT1 0 Wilms tumor protein WT33 TF 1291 0.0439244987968563 IL1RL1 C - Cellular Fate and Organization intracellular IEA extracellular region IEA integral to membrane IEA external side of plasma membrane IEA immune response NAS positive regulation of interleukin-5 production IEA positive regulation of macrophage activation IEA innate immune response IEA negative regulation of T-helper 1 type immune response IEA positive regulation of inflammatory response IEA negative regulation of interferon-gamma production IEA negative regulation of I-kappaB kinase/NF-kappaB cascade IEA hematopoietin/interferon-class (D200-domain) cytokine receptor activity TAS interleukin-1 receptor activity IEA receptor signaling protein activity TAS Interleukin-1 receptor-like 1; Protein ST2; Precursor 10527832 10936050 11478810 14702039 14759258 1482686 15340161 15489334 15815621 16286016 NA ILRL1 -1 Interleukin-1 receptor-like 1 Protein ST2 Precursor gene 1291 0.00955317868538724 CDK16 D - Genome Maintenance transport vesicle IEA neuron projection IEA cytoplasm IDA cell junction IEA synapse IEA extrinsic to internal side of plasma membrane IDA cell cycle IEA growth hormone secretion ISS spermatogenesis ISS exocytosis ISS neurite development ISS protein serine/threonine kinase activity IDA ATP binding IEA cyclin-dependent protein kinase activity IEA Cyclin-dependent kinase 16; 2.7.11.22; Cell division protein kinase 16; PCTAIRE-motif protein kinase 1; Serine/threonine-protein kinase PCTAIRE-1 14702039 15489334 15772651 1639063 17081983 18669648 18691976 19369195 20068231 21406692 22184064 22796189 22798068 NA CDK16 1 Cyclin-dependent kinase 16 2.7.11.22 Cell division protein kinase 16 PCTAIRE-motif protein kinase 1 Serine/threonine-protein kinase PCTAIRE-1 gene 1291 0.110807554138766 SPATS2 N - Not Matched cytoplasm IEA Spermatogenesis-associated serine-rich protein 2; Serine-rich spermatocytes and round spermatid 59 kDa protein; p59scr 12880961 14702039 15489334 18669648 19690332 NA SPAS2 1 Spermatogenesis-associated serine-rich protein 2 Serine-rich spermatocytes and round spermatid 59 kDa protein p59scr gene 1291 1.0277442233539E-4 HIST1H2BK D - Genome Maintenance nucleus IEA nucleosome IEA nucleosome assembly IEA defense response to bacterium IEA DNA binding IEA Histone H2B type 1-K; H2B K; HIRA-interacting protein 1 11859126 12408966 12757711 12860195 14574404 14702039 15019208 15489334 15951514 16283522 16307923 16457587 16627869 16713563 21726816 21925322 8620898 9710638 NA H2B1K 1 Histone H2B type 1-K H2B K HIRA-interacting protein 1 gene 1291 0.00116321476413408 N - Not Matched melanosome IEA Golgi apparatus TAS endoplasmic reticulum IDA extracellular region IEA platelet degranulation TAS platelet activation TAS calcium ion binding IEA Calumenin; Crocalbin; IEF SSP 9302; Precursor 10222138 12643545 12665801 12853948 14702039 15489334 16964243 17081065 18691976 19159218 20068231 21269460 9598325 9675259 NA CALU 1 Calumenin Crocalbin IEF SSP 9302 Precursor gene 1291 0.12035157949123 Protein FAM72B 15489334 16710414 NA FA72B 1 Protein FAM72B gene 1291 0.00137163971806715 SPDEF T - Transcription nucleus IEA positive regulation of apoptosis IDA positive regulation of transcription from RNA polymerase II promoter IEA multicellular organismal development TAS negative regulation of transcription from RNA polymerase II promoter IDA transcription, DNA-dependent IEA sequence-specific DNA binding IEA transcription factor activity IEA SAM pointed domain-containing Ets transcription factor; Prostate epithelium-specific Ets transcription factor; Prostate-specific Ets; Prostate-derived Ets factor 10625666 10675039 11809674 14574404 14702039 15489334 15882048 NA SPDEF 1 SAM pointed domain-containing Ets transcription factor Prostate epithelium-specific Ets transcription factor Prostate-specific Ets Prostate-derived Ets factor gene 1291 0.31687800227184 C - Cellular Fate and Organization extracellular matrix IDA collagen IEA cell adhesion IEA Collagen alpha-6(VI) chain; Precursor 16641997 17974005 18276594 19159218 NA CO6A6 -1 Collagen alpha-6(VI) chain Precursor gene 1291 0.0244174348753505 AIMP2 C - Cellular Fate and Organization nucleus IEA cytosol TAS negative regulation of cell proliferation IEA positive regulation of protein ubiquitination IEA apoptosis IEA tRNA aminoacylation for protein translation TAS Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; Multisynthase complex auxiliary component p38; Protein JTV-1 12690205 12819782 12853948 15220430 15489334 16135753 18029264 18695251 21269460 8666379 9878398 NA AIMP2 1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 Multisynthase complex auxiliary component p38 Protein JTV-1 gene 1291 1.05608763856695E-4 EPB41L3 C - Cellular Fate and Organization cytoplasm IEA plasma membrane NAS intercellular junction IDA cytoskeleton IEA extrinsic to membrane IEA cortical cytoskeleton organization and biogenesis TAS paranodal junction assembly ISS cortical actin cytoskeleton organization and biogenesis IEA regulation of cell shape ISS neurite morphogenesis ISS myelin maintenance ISS cytoskeletal anchoring TAS structural constituent of cytoskeleton TAS Band 4.1-like protein 3; 4.1B; Differentially expressed in adenocarcinoma of the lung protein 1; DAL-1 10231032 12234973 15489334 16964243 20068231 21269460 21406692 9892180 NA E41L3 -1 Band 4.1-like protein 3 4.1B Differentially expressed in adenocarcinoma of the lung protein 1 DAL-1 gene 1291 0.0922110429307214 C - Cellular Fate and Organization spectrin TAS cell junction IDA plasma membrane IDA nucleus IDA extrinsic to membrane IEA cortical actin cytoskeleton organization and biogenesis IEA structural molecule activity IEA Band 4.1-like protein 2; Generally expressed protein 4.1; 4.1G 14574404 14702039 16254212 16964243 17081983 17974005 18023480 18669648 19690332 20068231 21269460 21406692 22361696 9598318 NA E41L2 -1 Band 4.1-like protein 2 Generally expressed protein 4.1 4.1G gene 1291 3.6767342038056E-4 KRT8 C - Cellular Fate and Organization intermediate filament NAS cytoplasm IDA nucleoplasm IEA keratin filament IEA nuclear matrix IEA virus-host interaction IEA cytoskeleton organization and biogenesis NAS structural molecule activity IEA Keratin, type II cytoskeletal 8; Cytokeratin-8; CK-8; Keratin-8; K8; Type-II keratin Kb8 10809736 10973561 11781324 11788583 12724528 1371281 1374067 14702039 15489334 15731013 15846844 16000376 16541075 16608857 1691124 1692965 16964243 1705144 17081983 18669648 18691976 19188445 19369195 19608861 20068231 20729549 21269460 21406692 21908771 22967762 2434381 2471065 9054461 9150948 NA K2C8 1 Keratin, type II cytoskeletal 8 Cytokeratin-8 CK-8 Keratin-8 K8 Type-II keratin Kb8 gene 1291 3.05547532142329E-6 AGK C - Cellular Fate and Organization mitochondrial membrane IEA glycerolipid metabolic process IEA ceramide biosynthetic process IEA protein kinase C activation IEA diacylglycerol kinase activity IEA acylglycerol kinase activity IEA ATP binding IEA ceramide kinase activity IEA Acylglycerol kinase, mitochondrial; hAGK; 2.7.1.107; 2.7.1.94; Multiple substrate lipid kinase; HsMuLK; MuLK; Multi-substrate lipid kinase; Precursor 12853948 14702039 15489334 15939762 16269826 19608861 21269460 22277967 22284826 22415731 NA AGK 1 Acylglycerol kinase, mitochondrial hAGK 2.7.1.107 2.7.1.94 Multiple substrate lipid kinase HsMuLK MuLK Multi-substrate lipid kinase Precursor gene 1291 0.100977645694874 C - Cellular Fate and Organization sarcolemma IEA cytoplasm IEA sarcoglycan complex TAS integral to membrane IEA cytoskeleton IEA muscle development TAS cytoskeleton organization and biogenesis IEA Gamma-sarcoglycan; Gamma-SG; 35 kDa dystrophin-associated glycoprotein; 35DAG 10629222 10714584 15057823 15489334 7481775 8900232 8968757 NA SGCG -1 Gamma-sarcoglycan Gamma-SG 35 kDa dystrophin-associated glycoprotein 35DAG gene 1291 0.0051926145583678 TMPRSS4 F - Protein Fate integral to membrane NAS proteolysis NAS serine-type endopeptidase activity NAS scavenger receptor activity IEA Transmembrane protease serine 4; 3.4.21.-; Channel-activating protease 2; CAPH2; Membrane-type serine protease 2; MT-SP2 10825129 12975309 14702039 15489334 16554811 NA TMPS4 1 Transmembrane protease serine 4 3.4.21.- Channel-activating protease 2 CAPH2 Membrane-type serine protease 2 MT-SP2 gene 1291 0.00190723864225319 SGCE C - Cellular Fate and Organization sarcolemma IEA cytoplasm IEA integral to plasma membrane TAS sarcoglycan complex TAS cytoskeleton IEA muscle development TAS cell-matrix adhesion TAS calcium ion binding IEA Epsilon-sarcoglycan; Epsilon-SG 11528394 12402271 12853948 12975309 14702039 15079037 15193417 15258227 15489334 16227522 17853490 18175340 18362280 19066193 19159218 21796726 9405466 9475163 NA SGCE -1 Epsilon-sarcoglycan Epsilon-SG gene 1291 2.65919922758439E-4 C - Cellular Fate and Organization Z disc IEA cell-matrix junction IEA cell surface IDA nucleus IDA filopodium IDA cytosol TAS sarcolemma IDA dystrophin-associated glycoprotein complex IDA postsynaptic membrane IEA costamere IDA lipid raft IEA cytoskeleton TAS regulation of transcription, DNA-dependent IEA muscle filament sliding TAS peptide biosynthetic process IDA neurotransmitter receptor metabolic process IEA cellular protein complex assembly ISS muscle maintenance IEA olfactory nerve structural organization IEA muscle fiber development IEA muscle development NAS cardiac chronotropy IMP establishment of blood-nerve barrier IEA positive regulation of neuron differentiation IMP flagellum biogenesis TAS nucleus localization IEA nitric-oxide synthase binding ISS calcium ion binding IEA structural constituent of cytoskeleton TAS actin binding TAS zinc ion binding IEA myosin binding IDA structural constituent of muscle IDA Dystrophin 10573008 10734266 10747910 10801490 10932245 11495720 12354438 12359139 12632325 1319059 15489334 15772651 16000376 16710609 16959974 17081983 18669648 20068231 21269460 21396098 2407739 2569720 2648158 2668885 3205741 3282674 3428261 3607877 7592992 7844150 7849724 7951253 7981690 8045556 8401582 8541829 8576247 8817332 9170407 9370062 9851445 NA DMD -1 Dystrophin gene 7546 0.416234818250844 reported 1 mir 16384 0.272281784956411 novel 1 mir 1291 0.0617829085001869 REEP6 N - Not Matched integral to membrane IEA Receptor expression-enhancing protein 6; Polyposis locus protein 1-like 1 14702039 15489334 15550249 21269460 NA REEP6 1 Receptor expression-enhancing protein 6 Polyposis locus protein 1-like 1 gene 1291 0.325044433804753 PGM5 C - Cellular Fate and Organization sarcolemma IDA stress fiber IDA spot adherens junction IDA Z disc IBA dystrophin-associated glycoprotein complex ISS costamere IDA internal side of plasma membrane IDA focal adhesion IDA glucose metabolic process IEA cell adhesion IEA magnesium ion binding IEA structural molecule activity NAS intramolecular transferase activity, phosphotransferases IEA Phosphoglucomutase-like protein 5; Aciculin; Phosphoglucomutase-related protein; PGM-RP 14702039 15164053 15489334 8175905 8631316 9342213 NA PGM5 -1 Phosphoglucomutase-like protein 5 Aciculin Phosphoglucomutase-related protein PGM-RP gene 1291 5.71729576935814E-4 REEP5 N - Not Matched integral to membrane NAS Receptor expression-enhancing protein 5; Polyposis locus protein 1; Protein TB2 15489334 15550249 1651562 1678319 19608861 19665976 21269460 NA REEP5 -1 Receptor expression-enhancing protein 5 Polyposis locus protein 1 Protein TB2 gene 1291 0.0783685434449873 PGM3 F - Protein Fate cytosol IBA hemopoiesis IBA glucosamine metabolic process NAS UDP-N-acetylglucosamine biosynthetic process IBA dolichol-linked oligosaccharide biosynthetic process TAS protein amino acid N-linked glycosylation via asparagine TAS magnesium ion binding IEA phosphoacetylglucosamine mutase activity IDA Phosphoacetylglucosamine mutase; PAGM; 5.4.2.3; Acetylglucosamine phosphomutase; N-acetylglucosamine-phosphate mutase; Phosphoglucomutase-3; PGM 3 10721701 11004509 12174217 14574404 14702039 15489334 17974005 18669648 19690332 20068231 21269460 21406692 NA AGM1 1 Phosphoacetylglucosamine mutase PAGM 5.4.2.3 Acetylglucosamine phosphomutase N-acetylglucosamine-phosphate mutase Phosphoglucomutase-3 PGM 3 gene 1291 0.00259782917476168 REEP1 C - Cellular Fate and Organization mitochondrial membrane IEA membrane IDA endoplasmic reticulum IDA integral to membrane IEA cell death IEA protein insertion into membrane IDA microtubule binding IDA olfactory receptor binding IMP Receptor expression-enhancing protein 1 14702039 15489334 15550249 15815621 16826527 19690332 20200447 20718791 21618648 22703882 NA REEP1 -1 Receptor expression-enhancing protein 1 gene 1291 6.86433599827297E-4 OSBPL11 C - Cellular Fate and Organization lipid transport IEA fat cell differentiation IMP phospholipid binding IEA Oxysterol-binding protein-related protein 11; ORP-11; OSBP-related protein 11 11483621 11735225 14702039 15489334 16959974 16964243 17081983 18220336 18669648 18691976 19690332 20068231 21269460 21406692 NA OSB11 -1 Oxysterol-binding protein-related protein 11 ORP-11 OSBP-related protein 11 gene 1291 0.0257419865106196 GPM6B C - Cellular Fate and Organization plasma membrane ISS lipid raft ISS integral to membrane NAS positive regulation of bone mineralization IMP ossification IEA negative regulation of serotonin uptake ISS protein transport IEA regulation of focal adhesion formation IMP cell differentiation IEA nervous system development NAS Neuronal membrane glycoprotein M6-b; M6b 14702039 15489334 15772651 18581270 21406692 21638316 8661015 9674909 NA GPM6B -1 Neuronal membrane glycoprotein M6-b M6b gene 1291 0.167028605541731 GPM6A C - Cellular Fate and Organization plasma membrane ISS cell surface IDA dendritic spine IEA cell soma ISS integral to membrane IEA filopodium ISS stem cell differentiation IDA neurite morphogenesis ISS positive regulation of filopodium formation ISS neuron migration IDA synaptogenesis ISS calcium channel activity IEA Neuronal membrane glycoprotein M6-a; M6a 14702039 15489334 15815621 19298174 8661015 8893821 NA GPM6A -1 Neuronal membrane glycoprotein M6-a M6a gene 1291 0.220626047024778 LIMS2 N - Not Matched plasma membrane IEA nucleus IEA focal adhesion IEA cytosol TAS zinc ion binding IEA LIM and senescent cell antigen-like-containing domain protein 2; LIM-like protein 2; Particularly interesting new Cys-His protein 2; PINCH-2 12167643 14702039 15489334 15815621 18669648 19963065 NA LIMS2 -1 LIM and senescent cell antigen-like-containing domain protein 2 LIM-like protein 2 Particularly interesting new Cys-His protein 2 PINCH-2 gene 1291 0.00685925996823963 TRIM59 C - Cellular Fate and Organization endoplasmic reticulum IEA integral to membrane IEA negative regulation of I-kappaB kinase/NF-kappaB cascade IMP ubiquitin-protein ligase activity IEA zinc ion binding IEA Tripartite motif-containing protein 59; RING finger protein 104; Tumor suppressor TSBF-1 14702039 15489334 NA TRI59 1 Tripartite motif-containing protein 59 RING finger protein 104 Tumor suppressor TSBF-1 gene 1291 3.6767342038056E-4 C - Cellular Fate and Organization cytoplasm IEA cytoskeleton IEA phagocytosis IEA apoptosis IEA phospholipid binding IEA Engulfment and cell motility protein 3 14702039 15489334 15616553 NA ELMO3 1 Engulfment and cell motility protein 3 gene 1291 0.325044433804753 ELMO1 C - Cellular Fate and Organization plasma membrane IDA cytoskeleton IEA cytosol TAS Rac protein signal transduction IGI actin cytoskeleton organization and biogenesis IGI apoptosis NAS cell motility IGI viral reproduction TAS phagocytosis, engulfment IGI regulation of antiviral response by virus TAS phospholipid binding IEA Engulfment and cell motility protein 1; Protein ced-12 homolog 11230166 11595183 12029088 12134158 12690205 14702039 15489334 15952790 17881735 19608861 19690332 20869035 21269460 9179496 NA ELMO1 -1 Engulfment and cell motility protein 1 Protein ced-12 homolog gene 1291 0.201795580665838 LYPD1 N - Not Matched plasma membrane IEA anchored to membrane IEA Ly6/PLAUR domain-containing protein 1; Putative HeLa tumor suppressor; PHTS; Precursor 12975309 14702039 15489334 16303743 NA LYPD1 -1 Ly6/PLAUR domain-containing protein 1 Putative HeLa tumor suppressor PHTS Precursor gene 1291 0.0550793834643225 ALG6 F - Protein Fate endoplasmic reticulum membrane TAS integral to membrane IEA dolichol-linked oligosaccharide biosynthetic process TAS protein amino acid N-linked glycosylation via asparagine TAS glucosyltransferase activity IDA Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase; 2.4.1.267; Asparagine-linked glycosylation protein 6 homolog; Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase; Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase 10359825 10914684 10924277 11106564 11134235 11558905 11875054 12357336 14517965 14702039 15489334 16710414 NA ALG6 1 Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase 2.4.1.267 Asparagine-linked glycosylation protein 6 homolog Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase gene 1291 0.0347288524571649 LEPREL4 N - Not Matched synaptonemal complex TAS nucleolus TAS synaptonemal complex formation TAS Synaptonemal complex protein SC65; Leprecan-like protein 4; Nucleolar autoantigen No55 10952778 15489334 21269460 8862517 NA SC65 1 Synaptonemal complex protein SC65 Leprecan-like protein 4 Nucleolar autoantigen No55 gene 1291 0.0103440759589067 LIMCH1 N - Not Matched actomyosin structure organization and biogenesis IEA zinc ion binding IEA LIM and calponin homology domains-containing protein 1 10470851 12168954 15489334 15815621 16964243 17081983 17974005 18669648 20068231 21269460 21406692 NA LIMC1 -1 LIM and calponin homology domains-containing protein 1 gene 1291 0.0218918562607483 LEPREL1 C - Cellular Fate and Organization Golgi apparatus IDA endoplasmic reticulum lumen TAS basement membrane ISS negative regulation of cell proliferation IDA extracellular matrix organization and biogenesis TAS peptidyl-proline hydroxylation IDA L-ascorbic acid binding IEA iron ion binding IEA procollagen-proline 3-dioxygenase activity IDA oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA Prolyl 3-hydroxylase 2; 1.14.11.7; Leprecan-like protein 1; Myxoid liposarcoma-associated protein 4; Precursor 10449603 14702039 15063763 15489334 16959974 21885030 NA P3H2 -1 Prolyl 3-hydroxylase 2 1.14.11.7 Leprecan-like protein 1 Myxoid liposarcoma-associated protein 4 Precursor gene 1291 0.030922008657682 CALCOCO1 C - Cellular Fate and Organization nuclear chromatin IEA cytoplasm IDA nucleus IDA steroid hormone receptor signaling pathway ISS positive regulation of transcription from RNA polymerase II promoter IEA Wnt receptor signaling pathway IEA positive regulation of transcription, DNA-dependent IMP transcription, DNA-dependent ISS sequence-specific DNA binding IDA ligand-dependent nuclear receptor transcription coactivator activity IDA chromatin binding IEA Calcium-binding and coiled-coil domain-containing protein 1; Calphoglin; Coiled-coil coactivator protein; Sarcoma antigen NY-SAR-3 .1016/J.BBRC.2004.10.021 10819331 11230166 12601173 12975309 14702039 15489334 15498874 NA CACO1 -1 Calcium-binding and coiled-coil domain-containing protein 1 Calphoglin Coiled-coil coactivator protein Sarcoma antigen NY-SAR-3 gene 1291 1.20641378599824E-4 KLF9 C - Cellular Fate and Organization nucleus IEA progesterone receptor signaling pathway IEA regulation of transcription from RNA polymerase II promoter TAS embryo implantation IEA transcription, DNA-dependent IEA transcription factor activity TAS zinc ion binding IEA DNA binding IEA Krueppel-like factor 9; Basic transcription element-binding protein 1; BTE-binding protein 1; GC-box-binding protein 1; Transcription factor BTEB1 14702039 15164053 15489334 8051167 8291025 NA KLF9 -1 Krueppel-like factor 9 Basic transcription element-binding protein 1 BTE-binding protein 1 GC-box-binding protein 1 Transcription factor BTEB1 gene 1291 0.00337628959944939 KLF6 C - Cellular Fate and Organization intracellular IEA cytoplasm IEA nucleus TAS cytokine and chemokine mediated signaling pathway IEA B cell differentiation NAS positive regulation of transcription, DNA-dependent TAS transcription, DNA-dependent IEA zinc ion binding IEA nucleic acid binding IEA DNA binding IEA Krueppel-like factor 6; B-cell-derived protein 1; Core promoter element-binding protein; GC-rich sites-binding factor GBF; Proto-oncogene BCD1; Suppressor of tumorigenicity 12 protein; Transcription factor Zf9 11752579 14702039 15164054 15489334 15824733 9000136 9083102 9685731 9689109 NA KLF6 -1 Krueppel-like factor 6 B-cell-derived protein 1 Core promoter element-binding protein GC-rich sites-binding factor GBF Proto-oncogene BCD1 Suppressor of tumorigenicity 12 protein Transcription factor Zf9 gene 1907 2.62752358165506E-4 KLF4 C - Cellular Fate and Organization transcription factor complex IEA nuclear chromatin IDA negative regulation of protein kinase B signaling cascade IEA negative regulation of cell proliferation TAS negative regulation of interleukin-8 biosynthetic process IDA inhibition of NF-kappaB transcription factor IDA negative regulation of smooth muscle cell proliferation IEA negative regulation of phosphoinositide 3-kinase cascade IEA negative regulation of transcription from RNA polymerase II promoter IDA post-embryonic eye development (sensu Actinopterygii) IEA epidermal cell differentiation IEA epidermis morphogenesis IEA mesodermal cell fate determination TAS stem cell maintenance ISS negative regulation of inflammatory response TAS post-embryonic hemopoiesis IMP fat cell differentiation ISS positive regulation of hemoglobin biosynthetic process IMP negative regulation of caspase activity IDA double-stranded DNA binding IEA phosphoinositide 3-kinase regulator activity IEA zinc ion binding NAS Krueppel-like factor 4; Epithelial zinc finger protein EZF; Gut-enriched krueppel-like factor 10392904 14702039 15164053 15489334 17308127 17467953 18035408 18655026 18669648 20068231 20071344 21746878 9422764 NA KLF4 -1 Krueppel-like factor 4 Epithelial zinc finger protein EZF Gut-enriched krueppel-like factor gene 1291 0.103206130668939 C - Cellular Fate and Organization cytoplasm IEA microtubule associated complex NAS negative regulation of apoptosis IDA negative regulation of glucose import IDA transport TAS apoptosis IEA carbohydrate transport IEA response to morphine IEA Astrocytic phosphoprotein PEA-15; 15 kDa phosphoprotein enriched in astrocytes; Phosphoprotein enriched in diabetes; PED 10442631 10607908 15489334 17081983 18669648 20068231 21269460 21406692 8662970 9670003 NA PEA15 -1 Astrocytic phosphoprotein PEA-15 15 kDa phosphoprotein enriched in astrocytes Phosphoprotein enriched in diabetes PED gene 15748 1.78453951143576E-5 known 1 mir 1291 0.110807554138766 N - Not Matched mitochondrion IEA cytoplasm IDA Protein FAM136A 14702039 15489334 15815621 21269460 NA F136A 1 Protein FAM136A gene 1291 4.58870887597033E-4 MRGBP T - Transcription nucleus IDA H4/H2A histone acetyltransferase complex IEA regulation of transcription, DNA-dependent IEA transcription, DNA-dependent IEA regulation of growth IEA chromatin modification IEA MRG/MORF4L-binding protein; MRG-binding protein 11780052 12963728 14702039 15489334 16964243 18669648 19690332 20068231 21269460 NA MRGBP 1 MRG/MORF4L-binding protein MRG-binding protein gene 1291 0.00834791357145082 D - Genome Maintenance cytosol TAS liver development IEA DNA replication IEA protein homotetramerization IPI response to toxin IEA response to nutrient levels IEA thymidine metabolic process IEA gut development IEA pyrimidine nucleoside salvage TAS response to copper ion IEA pyrimidine base metabolic process TAS response to cortisol stimulus IEA zinc ion binding IDA ATP binding IEA thymidine kinase activity TAS Thymidine kinase, cytosolic; 2.7.1.21 14702039 15489334 15611477 15733844 16964243 17407781 18669648 19369195 20068231 21269460 3301530 3785218 6549046 9575153 NA KITH 1 Thymidine kinase, cytosolic 2.7.1.21 gene 1291 0.00150790326259068 BNIP2 C - Cellular Fate and Organization perinuclear region IEA nuclear envelope IDA cytosol TAS muscle cell differentiation TAS negative regulation of apoptosis TAS positive regulation of muscle cell differentiation TAS apoptosis IPI calcium ion binding TAS GTPase activator activity TAS BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 14702039 15489334 16572171 18088087 18669648 18691976 19690332 20068231 21406692 7954800 NA BNIP2 -1 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 gene 1291 0.0714360801321983 ARIH2 F - Protein Fate cytoplasm IDA nucleus IDA protein ubiquitination during ubiquitin-dependent protein catabolic process IDA developmental cell growth IDA ubiquitin-protein ligase activity IDA zinc ion binding TAS nucleic acid binding IEA E3 ubiquitin-protein ligase ARIH2; ARI-2; Protein ariadne-2 homolog; 6.3.2.-; Triad1 protein 10422847 10880484 10931946 15489334 16118314 17525332 17646546 19340006 21269460 NA ARI2 -1 E3 ubiquitin-protein ligase ARIH2 ARI-2 Protein ariadne-2 homolog 6.3.2.- Triad1 protein gene 1291 0.0141044082136543 T - Transcription perinuclear region ISS nucleus ISS integral to membrane IEA positive regulation of transcription from RNA polymerase II promoter ISS negative regulation of transcription from RNA polymerase II promoter ISS structural molecule activity IEA Motile sperm domain-containing protein 1 14702039 15489334 15772651 16959974 NA MSPD1 1 Motile sperm domain-containing protein 1 gene 1291 0.0717638596053337 N - Not Matched mitochondrial inner membrane TAS thalamus development IEA hippocampus development IEA cerebellar Purkinje cell layer development IEA midbrain development IEA pons development IEA hypothalamus development IEA pyramidal neuron development IEA subthalamus development IEA ubiquinol-cytochrome-c reductase activity IEA Cytochrome b-c1 complex subunit 8; Complex III subunit 8; Complex III subunit VIII; Ubiquinol-cytochrome c reductase complex 9.5 kDa protein; Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C 15489334 18439546 21269460 8592474 NA QCR8 1 Cytochrome b-c1 complex subunit 8 Complex III subunit 8 Complex III subunit VIII Ubiquinol-cytochrome c reductase complex 9.5 kDa protein Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C gene 1291 0.113998436121522 LAPTM4B A - Transport and Sensing integral to membrane IEA endomembrane system IEA transport IEA Lysosomal-associated transmembrane protein 4B; Lysosome-associated transmembrane protein 4-beta 11230166 12902989 15489334 16303743 NA LAP4B 1 Lysosomal-associated transmembrane protein 4B Lysosome-associated transmembrane protein 4-beta gene 1291 0.107607101424208 PGK1 C - Cellular Fate and Organization cytosol TAS gluconeogenesis TAS glycolysis TAS phosphoglycerate kinase activity ISS ATP binding ISS Phosphoglycerate kinase 1; 2.7.2.3; Cell migration-inducing gene 10 protein; Primer recognition protein 2; PRP 2 14702039 1547346 15489334 15592455 15772651 1586722 17081983 18463139 18669648 19608861 2001457 20068231 21269460 21406692 21908771 2324090 2814502 2995995 6099325 6188151 6933565 6941312 7391027 7391028 7440217 8043870 8615693 8673469 9075577 9744480 NA PGK1 1 Phosphoglycerate kinase 1 2.7.2.3 Cell migration-inducing gene 10 protein Primer recognition protein 2 PRP 2 gene 1291 0.00150790326259068 FHDC1 C - Cellular Fate and Organization actin cytoskeleton organization and biogenesis IEA FH2 domain-containing protein 1 11214970 15815621 21406692 NA FHDC1 -1 FH2 domain-containing protein 1 gene 1457 0.0136131056747202 SMARCC1 D - Genome Maintenance XY body IEA SWI/SNF complex IDA insulin receptor signaling pathway IEA regulation of transcription from RNA polymerase II promoter NAS positive regulation of transcription from RNA polymerase II promoter IEA organ morphogenesis IEA chromatin remodeling IDA nucleosome disassembly IDA positive regulation of transcription, DNA-dependent IDA transcription, DNA-dependent IEA nervous system development IEA chromatin binding IEA transcription coactivator activity NAS DNA binding IEA SWI/SNF complex subunit SMARCC1; BRG1-associated factor 155; BAF155; SWI/SNF complex 155 kDa subunit; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1 10078207 11018012 11238380 12837248 12917342 15144186 15489334 17081983 18669648 18765789 19608861 19690332 20068231 20829358 21269460 21406692 8804307 9744861 9891079 NA SMRC1 1 SWI/SNF complex subunit SMARCC1 BRG1-associated factor 155 BAF155 SWI/SNF complex 155 kDa subunit SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1 gene 1291 0.104397055026454 F - Protein Fate neuron projection IEA plasma membrane IDA nucleus IDA extracellular space IEA cytosol TAS hemostasis TAS methylglyoxal biosynthetic process IEA negative regulation of neuron apoptosis IEA humoral immune response TAS aldehyde catabolic process IEA gluconeogenesis TAS learning and/or memory IEA angiogenesis IEA negative regulation of caspase activity IEA glucose 6-phosphate metabolic process IEA glycolysis TAS intramolecular transferase activity IEA glucose-6-phosphate isomerase activity TAS monosaccharide binding IEA Glucose-6-phosphate isomerase; GPI; 5.3.1.9; Autocrine motility factor; AMF; Neuroleukin; NLK; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI; Sperm antigen 36; SA-36 10727272 11004567 11371164 11437381 12054796 12163179 12573240 12777791 14702039 15057824 15489334 15637053 16139798 18669648 19608861 19690332 21269460 21908771 2387591 3352745 7989588 8499925 8822952 8822954 9446754 9856489 NA G6PI 1 Glucose-6-phosphate isomerase GPI 5.3.1.9 Autocrine motility factor AMF Neuroleukin NLK Phosphoglucose isomerase PGI Phosphohexose isomerase PHI Sperm antigen 36 SA-36 gene 1291 0.0415525452242194 CENPK D - Genome Maintenance condensed chromosome kinetochore IEA nucleoplasm TAS cytosol TAS mitotic prometaphase TAS positive regulation of transcription from RNA polymerase II promoter IEA Centromere protein K; CENP-K; Interphase centromere complex protein 37; Protein AF-5alpha; p33 15489334 16622419 16622420 16716197 18045986 19381461 8950979 NA CENPK 1 Centromere protein K CENP-K Interphase centromere complex protein 37 Protein AF-5alpha p33 gene 1351 0.0750915366867177 LCP1 C - Cellular Fate and Organization cell junction IEA plasma membrane IDA actin filament IEA phagocytic cup IEA actin cytoskeleton IDA cytosol IDA organ regeneration IEA actin filament bundle formation IEA T cell activation during immune response IDA calcium ion binding NAS actin binding NAS Plastin-2; L-plastin; LC64P; Lymphocyte cytosolic protein 1; LCP-1 14702039 15057823 15489334 15592455 16636079 17294403 19367720 19608861 19690332 2111166 21269460 21406692 2252891 2378651 3211125 3261603 8428952 NA PLSL -1 Plastin-2 L-plastin LC64P Lymphocyte cytosolic protein 1 LCP-1 gene 1291 0.0170052773147686 EFNB2 C - Cellular Fate and Organization integral to plasma membrane TAS ephrin receptor signaling pathway IDA regulation of chemotaxis IDA virus-host interaction IEA cell migration during sprouting angiogenesis IDA cell-cell signaling TAS organ morphogenesis IEA cell adhesion IDA lymph vessel development IEA cell differentiation IEA nervous system development IEA ephrin receptor binding TAS Ephrin-B2; EPH-related receptor tyrosine kinase ligand 5; LERK-5; HTK ligand; HTK-L; Precursor 12734395 15057823 15489334 16007075 16477309 16867992 18488039 19836338 19875447 21269460 7534404 8559144 9533549 NA EFNB2 -1 Ephrin-B2 EPH-related receptor tyrosine kinase ligand 5 LERK-5 HTK ligand HTK-L Precursor gene 1291 0.00100778363875144 CYR61 C - Cellular Fate and Organization extracellular region IEA negative regulation of apoptosis IEA positive regulation of cell migration IDA positive regulation of apoptosis IEA cell proliferation TAS intussusceptive angiogenesis IEA regulation of cell growth IEA osteoblast differentiation IEA positive regulation of caspase activity IEA positive regulation of osteoblast differentiation IDA positive regulation of BMP signaling pathway IGI chemotaxis IEA extracellular matrix organization and biogenesis IEA positive regulation of transcription from RNA polymerase II promoter IDA positive regulation of protein kinase activity IDA extracellular matrix binding IEA heparin binding IEA Protein CYR61; CCN family member 1; Cysteine-rich angiogenic inducer 61; Insulin-like growth factor-binding protein 10; IBP-10; IGF-binding protein 10; IGFBP-10; Protein GIG1; Precursor 10446209 10821835 10852911 11287419 11584015 11810026 15489334 9135077 9446626 9536281 NA CYR61 -1 Protein CYR61 CCN family member 1 Cysteine-rich angiogenic inducer 61 Insulin-like growth factor-binding protein 10 IBP-10 IGF-binding protein 10 IGFBP-10 Protein GIG1 Precursor gene 1291 0.193676256758731 JUP C - Cellular Fate and Organization fascia adherens IBA intermediate filament IEA desmosome IDA zonula adherens ISS basolateral plasma membrane IBA Z disc IBA internal side of plasma membrane ISS catenin complex IDA actin cytoskeleton IBA lateral plasma membrane IEA apicolateral plasma membrane IEA cytosol ISS gastrulation IBA regulation of apoptosis IDA ectoderm development IBA protein heterooligomerization IEA oocyte development IBA nervous system development IBA cell morphogenesis IBA positive regulation of transcription factor activity IDA morphogenesis of embryonic epithelium IBA cell migration IMP detection of mechanical stimulus IDA regulation of cell proliferation IDA positive regulation of protein import into nucleus IDA skin development IBA cytoskeletal anchoring NAS protein kinase binding IBA structural constituent of cell wall IC transcription coactivator activity IDA protein homodimerization activity ISS Junction plakoglobin; Catenin gamma; Desmoplakin III; Desmoplakin-3 10902626 11016852 12370829 14517306 15489334 16625196 17081983 17924338 19759396 19863551 20031617 20068231 21062920 21269460 2726765 7982500 9139698 9152027 NA PLAK 1 Junction plakoglobin Catenin gamma Desmoplakin III Desmoplakin-3 gene 4091 0.00124362212165447 D - Genome Maintenance transcription factor complex IEA nuclear euchromatin IDA transcriptional repressor complex IEA nucleoplasm TAS cytosol IEA response to hydrogen peroxide IEA axon regeneration IEA negative regulation of cell proliferation IEA membrane depolarization IEA release of cytochrome c from mitochondria IEA positive regulation of fibroblast proliferation IEA stress-activated MAPK cascade TAS response to cAMP IEA negative regulation of protein amino acid autophosphorylation IEA regulation of transcription factor activity TAS negative regulation of neuron apoptosis IEA positive regulation of neuron apoptosis IEA positive regulation of monocyte differentiation IEA MyD88-dependent toll-like receptor signaling pathway TAS regulation of cell cycle IEA response to lipopolysaccharide IEA transforming growth factor beta receptor signaling pathway IDA monocyte differentiation IEA learning IEA microglial cell activation IEA response to radiation IEA response to drug IEA positive regulation of DNA replication IEA aging IEA angiogenesis IEA cellular response to potassium ion starvation IEA positive regulation of smooth muscle cell proliferation IEA negative regulation of DNA binding IDA response to mechanical stimulus IEA liver development IEA Toll signaling pathway TAS positive regulation of endothelial cell proliferation IEA SMAD protein nuclear translocation IDA innate immune response TAS circadian rhythm IEA negative regulation of transcription, DNA-dependent IDA leading edge cell differentiation IEA double-stranded DNA binding IEA RNA polymerase II transcription factor activity, enhancer binding IDA transcription coactivator activity IDA Rho GTPase activator activity IDA Transcription factor AP-1; Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39 10196196 10376527 10995748 11689449 12087103 15467742 15489334 16478997 16710414 17210646 17804415 1846781 18650425 18669648 19690332 20068231 20852630 21177766 21406692 22307329 2825349 3194415 7816143 8464713 8662824 8663478 8837781 8855261 9732876 NA JUN -1 Transcription factor AP-1 Activator protein 1 AP1 Proto-oncogene c-Jun V-jun avian sarcoma virus 17 oncogene homolog p39 TF 1291 0.291811754361373 ARHGEF40 C - Cellular Fate and Organization cytoplasm IEA regulation of Rho protein signal transduction IEA phospholipid binding IEA Rho guanyl-nucleotide exchange factor activity IEA Rho guanine nucleotide exchange factor 40; Protein SOLO 12508121 14702039 15489334 16143467 16964243 17974005 18669648 19369195 21406692 NA ARH40 -1 Rho guanine nucleotide exchange factor 40 Protein SOLO gene 1291 0.325044433804753 TRIM29 T - Transcription cytoplasm IEA transcription from RNA polymerase II promoter TAS negative regulation of transcription from RNA polymerase II promoter IEA transcription factor activity TAS zinc ion binding IEA Tripartite motif-containing protein 29; Ataxia telangiectasia group D-associated protein 11331580 15489334 16959974 16964243 18669648 18691976 20068231 21269460 7644499 8188213 8647648 NA TRI29 -1 Tripartite motif-containing protein 29 Ataxia telangiectasia group D-associated protein gene 1291 0.00137163971806715 TRIM27 D - Genome Maintenance cytoplasm IDA nuclear membrane IDA integral to plasma membrane TAS PML body IEA nucleoplasm IDA cell proliferation TAS negative regulation of gene expression, epigenetic IDA negative regulation of tumor necrosis factor-alpha production IMP negative regulation of transcription from RNA polymerase II promoter IDA negative regulation of protein kinase activity IDA spermatogenesis TAS negative regulation of adaptive immune response IMP transcription, DNA-dependent IEA ubiquitin-protein ligase activity IDA zinc ion binding IEA nucleic acid binding TAS transmembrane receptor protein tyrosine kinase activity TAS DNA binding IEA metal ion binding TAS Zinc finger protein RFP; 6.3.2.-; RING finger protein 76; Ret finger protein; Tripartite motif-containing protein 27 10504338 10976108 11331580 12445133 12787916 12807881 1437549 14530259 14574404 15489334 15837424 20068231 20864041 22128329 3037315 3380101 9247190 9570750 NA TRI27 1 Zinc finger protein RFP 6.3.2.- RING finger protein 76 Ret finger protein Tripartite motif-containing protein 27 gene 1392 0.0847839323828339 PTP4A2 C - Cellular Fate and Organization cytoplasm IDA plasma membrane IEA early endosome IEA prenylated protein tyrosine phosphatase activity TAS Protein tyrosine phosphatase type IVA 2; 3.1.3.48; HU-PP-1; OV-1; PTP(CAAXII); Protein-tyrosine phosphatase 4a2; Protein-tyrosine phosphatase of regenerating liver 2; PRL-2; Precursor 10940933 11447212 11734337 12235145 12516958 14643450 14702039 15489334 16710414 21269460 7490091 8529999 8661118 9018080 NA TP4A2 1 Protein tyrosine phosphatase type IVA 2 3.1.3.48 HU-PP-1 OV-1 PTP(CAAXII) Protein-tyrosine phosphatase 4a2 Protein-tyrosine phosphatase of regenerating liver 2 PRL-2 Precursor gene 1291 0.0295186898975597 TRIM25 T - Transcription cell junction IDA nucleus IDA cytosol TAS defense response to virus IEA virus-host interaction IEA innate immune response TAS negative regulation of interferon type I production TAS ubiquitin-protein ligase activity IEA transcription factor activity TAS zinc ion binding IEA E3 ubiquitin/ISG15 ligase TRIM25; 6.3.2.19; 6.3.2.n3; Estrogen-responsive finger protein; RING finger protein 147; Tripartite motif-containing protein 25; Ubiquitin/ISG15-conjugating enzyme TRIM25; Zinc finger protein 147 15130519 15489334 15592455 16352599 16625196 17069755 17222803 17392790 18669648 19454348 19608861 20068231 21269460 21406692 8248217 NA TRI25 -1 E3 ubiquitin/ISG15 ligase TRIM25 6.3.2.19 6.3.2.n3 Estrogen-responsive finger protein RING finger protein 147 Tripartite motif-containing protein 25 Ubiquitin/ISG15-conjugating enzyme TRIM25 Zinc finger protein 147 gene 1291 0.348990914656669 C - Cellular Fate and Organization cytoplasm IDA axonemal dynein complex TAS fertilization (sensu Metazoa) TAS cell motility TAS microtubule motor activity TAS Axonemal dynein light intermediate polypeptide 1; Inner dynein arm light chain, axonemal; hp28 14702039 15489334 16710414 16959974 17974005 9284741 NA IDLC -1 Axonemal dynein light intermediate polypeptide 1 Inner dynein arm light chain, axonemal hp28 gene 1291 0.0994998451839461 NFKBIA C - Cellular Fate and Organization plasma membrane IDA nucleus IDA cytosol TAS T cell receptor signaling pathway TAS negative regulation of Notch signaling pathway IEA nerve growth factor receptor signaling pathway TAS cytoplasmic sequestering of NF-kappaB IMP apoptosis TAS inhibition of NF-kappaB transcription factor IDA negative regulation of DNA binding NAS positive regulation of cellular protein metabolic process IMP Toll signaling pathway TAS activation of NF-kappaB transcription factor TAS negative regulation of myeloid cell differentiation IEA virus-host interaction IEA regulation of cell proliferation IEA MyD88-dependent toll-like receptor signaling pathway TAS innate immune response TAS positive regulation of transcription from RNA polymerase II promoter IDA positive regulation of interferon type I production TAS response to muramyl dipeptide IEA response to exogenous dsRNA IEA lipopolysaccharide-mediated signaling pathway IEA protein import into nucleus, translocation IEA NF-kappaB binding IDA nuclear localization sequence binding IPI NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3 10329681 10437795 10454581 10637284 10655476 10657303 10783893 10882136 11124955 12508121 14523047 14702039 1493333 15489334 16648481 17003112 17956732 1829648 18412279 20347421 20356841 20504922 7479976 8622692 8657102 8657113 8797825 9566872 9865693 9865694 NA IKBA -1 NF-kappa-B inhibitor alpha I-kappa-B-alpha IkB-alpha IkappaBalpha Major histocompatibility complex enhancer-binding protein MAD3 gene 1291 0.0750711142623216 BPHL R - Stress and Defence mitochondrion ISS amino acid metabolic process TAS response to toxin TAS hydrolase activity IEA Valacyclovir hydrolase; VACVase; Valacyclovirase; 3.1.-.-; Biphenyl hydrolase-like protein; Biphenyl hydrolase-related protein; Bph-rp; Breast epithelial mucin-associated antigen; MCNAA; Precursor 12732646 14574404 15489334 15832508 18256025 19608861 21269460 2393862 7759552 9721218 NA BPHL 1 Valacyclovir hydrolase VACVase Valacyclovirase 3.1.-.- Biphenyl hydrolase-like protein Biphenyl hydrolase-related protein Bph-rp Breast epithelial mucin-associated antigen MCNAA Precursor gene 1291 0.00154066956916429 N - Not Matched mitochondrial matrix TAS proline biosynthetic process IDA nucleotide binding IEA pyrroline-5-carboxylate reductase activity IDA Pyrroline-5-carboxylate reductase 1, mitochondrial; P5C reductase 1; P5CR 1; 1.5.1.2 15489334 16625196 16730026 1730675 19576563 19648921 20068231 21269460 22052856 NA P5CR1 1 Pyrroline-5-carboxylate reductase 1, mitochondrial P5C reductase 1 P5CR 1 1.5.1.2 gene 1291 0.00458749974480071 HYOU1 M - Other Metabolism endoplasmic reticulum lumen TAS unfolded protein response, activation of signaling protein activity TAS ATP binding IEA Hypoxia up-regulated protein 1; 150 kDa oxygen-regulated protein; ORP-150; 170 kDa glucose-regulated protein; GRP-170; Precursor 10037731 10965054 12475965 12754519 14702039 16263699 16335952 17131193 19159218 19349973 21269460 9020069 NA HYOU1 1 Hypoxia up-regulated protein 1 150 kDa oxygen-regulated protein ORP-150 170 kDa glucose-regulated protein GRP-170 Precursor gene 1291 0.0176700252647508 MASP1 F - Protein Fate extracellular space IDA negative regulation of complement activation IDA proteolysis IEA complement activation, lectin pathway IMP serine-type endopeptidase activity IDA calcium ion binding IDA Mannan-binding lectin serine protease 1; 3.4.21.-; Complement factor MASP-3; Complement-activating component of Ra-reactive factor; Mannose-binding lectin-associated serine protease 1; MASP-1; Mannose-binding protein-associated serine protease; Ra-reactive factor serine protease p100; RaRF; Serine protease 5; Mannan-binding lectin serine protease 1 heavy chain; Mannan-binding lectin serine protease 1 light chain; Precursor 10475605 10679061 10878362 10946292 11290788 11485744 11527969 11907111 12421953 12538697 14702039 15034049 15489334 16335952 16554018 16641997 17182967 17974005 18596036 21258343 8018603 8240317 8921412 9087411 9367419 NA MASP1 -1 Mannan-binding lectin serine protease 1 3.4.21.- Complement factor MASP-3 Complement-activating component of Ra-reactive factor Mannose-binding lectin-associated serine protease 1 MASP-1 Mannose-binding protein-associated serine protease Ra-reactive factor serine protease p100 RaRF Serine protease 5 Mannan-binding lectin serine protease 1 heavy chain Mannan-binding lectin serine protease 1 light chain Precursor gene 1291 0.0483359921870727 F - Protein Fate cytoplasm IEA nucleus IEA protein ubiquitination IEA F-box only protein 32; Atrogin-1; Muscle atrophy F-box protein; MAFbx 11679633 14702039 15531760 16421571 22249105 NA FBX32 1 F-box only protein 32 Atrogin-1 Muscle atrophy F-box protein MAFbx gene 1291 0.21126419773979 BCL6B T - Transcription nucleus IEA negative regulation of transcription from RNA polymerase II promoter IEA zinc ion binding IEA DNA binding IEA B-cell CLL/lymphoma 6 member B protein; Bcl6-associated zinc finger protein; Zinc finger protein 62 11855826 15489334 16625196 NA BCL6B -1 B-cell CLL/lymphoma 6 member B protein Bcl6-associated zinc finger protein Zinc finger protein 62 gene 1339 4.6326975573175E-4 SMARCA5 D - Genome Maintenance condensed chromosome IDA nucleolus IDA nucleoplasm TAS NURF complex IDA RSF complex IPI chromatin silencing complex IEA transcription initiation IDA regulation of transcription from RNA polymerase II promoter TAS chromatin silencing at rDNA IEA nucleosome spacing IDA embryonic development IEA double-strand break repair IEA helicase activity TAS nucleosome binding IEA DNA binding IDA ATP binding IDA ATPase activity IDA SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5; 3.6.4.-; Sucrose nonfermenting protein 2 homolog; hSNF2H 10655480 10880450 10914549 11435432 11980720 12198550 12434153 12972596 15284901 15489334 15543136 16603771 17081983 17693683 18669648 18691976 19608861 19690332 20068231 21269460 21406692 9730600 NA SMCA5 -1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5 3.6.4.- Sucrose nonfermenting protein 2 homolog hSNF2H gene 1291 1.0 SMARCA4 D - Genome Maintenance nuclear chromatin IDA SWI/SNF complex IDA positive regulation of transcription factor activity IDA negative regulation of cell growth IMP chromatin remodeling IDA nucleosome disassembly IDA negative regulation of transcription from RNA polymerase II promoter TAS negative regulation of S phase of mitotic cell cycle TAS nervous system development IEA transcription corepressor activity IDA helicase activity TAS ATP binding IEA DNA binding IEA DNA-dependent ATPase activity IGI Transcription activator BRG1; 3.6.4.-; ATP-dependent helicase SMARCA4; BRG1-associated factor 190A; BAF190A; Mitotic growth and transcription activator; Protein BRG-1; Protein brahma homolog 1; SNF2-beta; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 10204490 11085541 11839798 12837248 12917342 15057824 15075294 16051670 16964243 17081983 17274598 17525332 17582821 18386774 18669648 18765789 19571879 19608861 19690332 20068231 20137775 20418909 21269460 21406692 22426308 8208605 8232556 9590696 NA SMCA4 0 Transcription activator BRG1 3.6.4.- ATP-dependent helicase SMARCA4 BRG1-associated factor 190A BAF190A Mitotic growth and transcription activator Protein BRG-1 Protein brahma homolog 1 SNF2-beta SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 TF 1291 0.0218918562607483 KLC1 C - Cellular Fate and Organization kinesin complex ISS microtubule IEA cytosol ISS antigen processing and presentation of exogenous peptide antigen via MHC class II TAS blood coagulation TAS virus-host interaction IEA microtubule-based movement TAS motor activity TAS microtubule motor activity IEA Kinesin light chain 1; KLC 1 12508121 12839500 15489334 17081983 18220336 18669648 18691976 19690332 20068231 20074060 21406692 21925109 8274221 NA KLC1 -1 Kinesin light chain 1 KLC 1 gene 1380 0.00208005594674944 SMARCA2 D - Genome Maintenance nuclear chromatin IDA SWI/SNF complex IDA nucleoplasm TAS intermediate filament cytoskeleton IDA negative regulation of cell growth IMP negative regulation of cell proliferation IEA chromatin remodeling TAS negative regulation of transcription from RNA polymerase II promoter TAS nervous system development IEA helicase activity TAS ATP binding IEA DNA-dependent ATPase activity TAS Probable global transcription activator SNF2L2; 3.6.4.-; ATP-dependent helicase SMARCA2; BRG1-associated factor 190B; BAF190B; Protein brahma homolog; hBRM; SNF2-alpha; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 12837248 15075294 15164053 17081983 17525332 18318008 18669648 18765789 19608861 19690332 20068231 21269460 22366787 22426308 8208605 8223438 NA SMCA2 -1 Probable global transcription activator SNF2L2 3.6.4.- ATP-dependent helicase SMARCA2 BRG1-associated factor 190B BAF190B Protein brahma homolog hBRM SNF2-alpha SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 gene 1292 3.24344925183363E-4 F - Protein Fate perinuclear region IDA intrinsic to endosome membrane TAS plasma membrane IDA integral to membrane IDA external side of plasma membrane IDA early endosome IDA heart development IMP proteolysis IEA positive regulation of receptor recycling IMP embryonic digit morphogenesis IMP ear development IMP regulation of vasoconstriction IC peptide hormone binding IC metalloendopeptidase activity ISS metal ion binding IEA Endothelin-converting enzyme 1; ECE-1; 3.4.24.71 10491078 14702039 15489334 16263699 16710414 17081983 18669648 18992253 19159218 19349973 19690332 21269460 7695628 7805846 7864876 8530372 9396733 9915973 NA ECE1 1 Endothelin-converting enzyme 1 ECE-1 3.4.24.71 gene 1291 0.00171921799516021 DPAGT1 F - Protein Fate integral to endoplasmic reticulum membrane ISS dolichol biosynthetic process IDA UDP-N-acetylglucosamine metabolic process IEA dolichol-linked oligosaccharide biosynthetic process TAS protein oligomerization ISS protein amino acid N-linked glycosylation via asparagine TAS UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity IDA transferase activity, transferring glycosyl groups IEA phospho-N-acetylmuramoyl-pentapeptide-transferase activity IEA UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase; 2.7.8.15; GlcNAc-1-P transferase; G1PT; GPT; N-acetylglucosamine-1-phosphate transferase 12872255 15489334 16959974 22742743 9451016 NA GPT 1 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 2.7.8.15 GlcNAc-1-P transferase G1PT GPT N-acetylglucosamine-1-phosphate transferase gene 1317 2.14304624906491E-6 SMAD7 C - Cellular Fate and Organization transcription factor complex IEA plasma membrane IDA nucleoplasm TAS cytosol TAS ureteric bud development IEA negative regulation of cell migration TAS negative regulation of apoptosis TAS transcription initiation from RNA polymerase II promoter TAS positive regulation of cell-cell adhesion IDA ventricular cardiac muscle morphogenesis ISS protein stabilization IDA positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA artery morphogenesis ISS negative regulation of transcription from RNA polymerase II promoter IDA BMP signaling pathway TAS negative regulation of transcription factor activity IDA negative regulation of BMP signaling pathway IDA positive regulation of transcription from RNA polymerase II promoter TAS positive regulation of protein ubiquitination IDA negative regulation of ubiquitin ligase activity IDA transforming growth factor beta receptor signaling pathway TAS negative regulation of transforming growth factor beta receptor signaling pathway IDA transcription factor activity IEA transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity IDA metal ion binding IEA Mothers against decapentaplegic homolog 7; MAD homolog 7; Mothers against DPP homolog 7; Mothers against decapentaplegic homolog 8; MAD homolog 8; Mothers against DPP homolog 8; SMAD family member 7; SMAD 7; Smad7; hSMAD7 10647776 10708948 10708949 11163210 11278251 11483516 12023024 12408818 14657019 14702039 14718519 14993265 15489334 16061177 16177791 16601693 16641086 17327236 17934461 9215638 9256479 9335507 9759503 9892009 NA SMAD7 -1 Mothers against decapentaplegic homolog 7 MAD homolog 7 Mothers against DPP homolog 7 Mothers against decapentaplegic homolog 8 MAD homolog 8 Mothers against DPP homolog 8 SMAD family member 7 SMAD 7 Smad7 hSMAD7 gene 1291 0.0580578706980573 NBEA N - Not Matched Golgi trans face ISS plasma membrane ISS cytosol ISS endomembrane system ISS protein localization IEA Neurobeachin; Lysosomal-trafficking regulator 2; Protein BCL8B 10997877 12160729 12234919 14702039 15057823 17974005 21406692 NA NBEA -1 Neurobeachin Lysosomal-trafficking regulator 2 Protein BCL8B gene 1291 0.0385082947407456 SMAD6 D - Genome Maintenance transcription factor complex IEA nucleus IDA cytosol TAS ureteric bud development IEA negative regulation of apoptosis IMP response to estrogen stimulus IEA cell-substrate adhesion IMP zygotic determination of dorsal/ventral axis IMP BMP signaling pathway TAS transcription, DNA-dependent IEA negative regulation of BMP signaling pathway IDA immune response IMP positive regulation of S phase of mitotic cell cycle IMP transforming growth factor beta receptor signaling pathway IEA negative regulation of caspase activity IMP negative regulation of transforming growth factor beta receptor signaling pathway IMP transcription factor activity IEA transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity IDA chromatin binding IDA metal ion binding IEA Mothers against decapentaplegic homolog 6; MAD homolog 6; Mothers against DPP homolog 6; SMAD family member 6; SMAD 6; Smad6; hSMAD6 10647776 10708948 10708949 10722652 11284962 11483516 14657019 15489334 16491121 16601693 16951688 22275001 8673135 9436979 9712726 9759503 NA SMAD6 -1 Mothers against decapentaplegic homolog 6 MAD homolog 6 Mothers against DPP homolog 6 SMAD family member 6 SMAD 6 Smad6 hSMAD6 gene 3031 1.0 SMAD4 D - Genome Maintenance centrosome IDA activin responsive factor complex IDA cytosol TAS ureteric bud branching IEA negative regulation of cell growth IDA negative regulation of cell proliferation IEA transcription initiation from RNA polymerase II promoter TAS cell proliferation IEA positive regulation of BMP signaling pathway IMP developmental growth IEA neural crest cell differentiation IEA positive regulation of transcription from RNA polymerase II promoter IDA palate development ISS transforming growth factor beta receptor signaling pathway IDA positive regulation of transforming growth factor beta receptor signaling pathway IDA response to hypoxia IMP negative regulation of protein catabolic process IMP formation of anatomical boundary IEA regulation of binding IEA neuron fate commitment IEA BMP signaling pathway IDA negative regulation of transcription from RNA polymerase II promoter TAS embryonic development (sensu Mammalia) IEA gastrulation (sensu Deuterostomia) IEA SMAD protein complex assembly IDA endoderm development IEA sebaceous gland development IEA mesoderm development IEA regulation of hair follicle development IEA transforming growth factor beta receptor, common-partner cytoplasmic mediator activity IDA transcription factor activity IEA chromatin binding IEA metal ion binding IEA Mothers against decapentaplegic homolog 4; MAD homolog 4; Mothers against DPP homolog 4; Deletion target in pancreatic carcinoma 4; SMAD family member 4; SMAD 4; Smad4; hSMAD4 10636916 10647180 10660046 11224571 11741830 11818334 12417513 12941698 14525983 14630787 14702039 15031030 15350224 15489334 15799969 15820681 16959974 17099224 17327236 18568018 19135894 19608861 21269460 21898662 22158539 22243968 8553070 8774881 9098646 9214508 9389648 9670020 9707553 9811934 NA SMAD4 0 Mothers against decapentaplegic homolog 4 MAD homolog 4 Mothers against DPP homolog 4 Deletion target in pancreatic carcinoma 4 SMAD family member 4 SMAD 4 Smad4 hSMAD4 TF 1291 0.148472992584061 PMEPA1 C - Cellular Fate and Organization plasma membrane TAS early endosome membrane TAS integral to membrane NAS transforming growth factor beta receptor signaling pathway TAS negative regulation of transforming growth factor beta receptor signaling pathway TAS androgen receptor signaling pathway NAS Transmembrane prostate androgen-induced protein; Solid tumor-associated 1 protein 10873380 11568975 11780052 12670906 12907594 15489334 18703514 NA PMEPA 1 Transmembrane prostate androgen-induced protein Solid tumor-associated 1 protein gene 3659 1.0 SMAD3 D - Genome Maintenance receptor complex IMP transcription factor complex IDA plasma membrane IEA nuclear inner membrane IDA cytosol TAS ureteric bud development IEA negative regulation of cell growth IDA transcription initiation from RNA polymerase II promoter TAS somitogenesis IEA thyroid gland development IEA positive regulation of transcription factor import into nucleus IDA embryonic cranial skeleton morphogenesis IEA embryonic pattern specification IEA heart looping IEA developmental growth IEA transport IDA regulation of striated muscle development IEA transforming growth factor beta receptor signaling pathway IDA immune system development IEA regulation of epithelial cell proliferation IEA positive regulation of bone mineralization IEA positive regulation of cell migration IEA mesoderm formation IEA negative regulation of transcription from RNA polymerase II promoter IDA embryonic development (sensu Mammalia) IEA intercellular junction assembly and maintenance IMP liver development IEA SMAD protein complex assembly IDA T cell activation IEA osteoblast development IEA negative regulation of progression through mitotic cell cycle IMP positive regulation of stress fiber formation IEA wound healing TAS regulation of immune response IEA paraxial mesoderm morphogenesis IEA positive regulation of interleukin-1 beta production IEA release of cytochrome c from mitochondria IEA positive regulation of focal adhesion formation IEA positive regulation of positive chemotaxis IEA immune response IMP positive regulation of transcription from RNA polymerase II promoter IDA primary microRNA processing TAS cell cycle arrest IMP positive regulation of chondrocyte differentiation IEA negative regulation of transforming growth factor beta receptor signaling pathway TAS response to hypoxia IMP negative regulation of apoptosis IEA caspase activation IMP negative regulation of protein catabolic process IMP protein stabilization IMP regulation of binding IEA induction of apoptosis IMP negative regulation of osteoblast differentiation IEA endoderm development IEA negative regulation of inflammatory response IEA evasion of host defenses by virus IDA embryonic foregut morphogenesis IEA negative regulation of protein amino acid phosphorylation IMP transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity IDA ubiquitin binding IDA double-stranded DNA binding IEA transcription factor activity IDA zinc ion binding IDA chromatin DNA binding IEA Mothers against decapentaplegic homolog 3; MAD homolog 3; Mad3; Mothers against DPP homolog 3; hMAD-3; JV15-2; SMAD family member 3; SMAD 3; Smad3; hSMAD3 10995748 11224571 11274402 11278756 11387212 11427533 12154125 12686552 14525983 14702039 15241418 15350224 15489334 15561701 15588252 15601644 15647271 15799969 15897867 16156666 16200078 16449645 16572171 16751101 16751102 16862174 16959974 17099224 17292623 17327236 18568018 18669648 18794808 19049980 19218245 19289081 20935647 21217753 21269460 21778426 21947082 8673135 8774881 9311995 9464505 9665135 9670020 9732876 9741623 9843571 9865696 9892009 NA SMAD3 0 Mothers against decapentaplegic homolog 3 MAD homolog 3 Mad3 Mothers against DPP homolog 3 hMAD-3 JV15-2 SMAD family member 3 SMAD 3 Smad3 hSMAD3 TF 1291 0.0125304158240803 N - Not Matched integral to membrane IEA fatty acid biosynthetic process IEA iron ion binding IEA oxidoreductase activity IEA Uncharacterized protein C5orf4 14702039 15489334 NA CE004 -1 Uncharacterized protein C5orf4 gene 2395 1.0 SMAD2 C - Cellular Fate and Organization activin responsive factor complex IDA cytosol TAS ureteric bud development IEA negative regulation of cell proliferation IEA transcription initiation from RNA polymerase II promoter TAS lung development IEA post-embryonic development IEA anterior/posterior pattern formation ISS embryonic cranial skeleton morphogenesis IEA positive regulation of BMP signaling pathway IMP developmental growth IEA organ growth IEA positive regulation of transcription from RNA polymerase II promoter ISS primary microRNA processing TAS palate development ISS transforming growth factor beta receptor signaling pathway IDA negative regulation of transforming growth factor beta receptor signaling pathway TAS mesoderm formation ISS regulation of binding ISS negative regulation of transcription from RNA polymerase II promoter TAS zygotic determination of dorsal/ventral axis IMP embryonic development (sensu Mammalia) IEA response to glucose stimulus IEA common-partner SMAD protein phosphorylation IDA SMAD protein complex assembly IDA cell fate commitment ISS endoderm development IEA pancreas development IEA embryonic foregut morphogenesis IEA paraxial mesoderm morphogenesis ISS insulin secretion IEA transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity IDA transcription factor activity IDA double-stranded DNA binding ISS chromatin binding IEA metal ion binding IEA Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2 10615055 10647776 10708948 10708949 11278756 11387212 11389444 11879191 12193595 15350224 15489334 15601644 15647271 16200078 16751101 16751102 16862174 16959974 17074756 17099224 17292623 17327236 18568018 18669648 18691976 19049980 19289081 20068231 21269460 21947082 8673135 8752209 8774881 8980228 9136927 9346908 9389648 9503010 9670020 9702198 9759503 9865696 9873005 9892009 NA SMAD2 0 Mothers against decapentaplegic homolog 2 MAD homolog 2 Mothers against DPP homolog 2 JV18-1 Mad-related protein 2 hMAD-2 SMAD family member 2 SMAD 2 Smad2 hSMAD2 TF 1291 2.15150330025378E-4 RAB25 C - Cellular Fate and Organization cytoplasmic membrane-bound vesicle IEA cytoplasmic vesicle IDA pseudopodium membrane IEA pseudopodium IDA positive regulation of cell proliferation IDA pseudopodium organization and biogenesis IDA small GTPase mediated signal transduction IEA protein transport IEA GTP binding IEA Ras-related protein Rab-25; CATX-8; Precursor 11495908 15489334 15502842 16710414 17925226 21269460 NA RAB25 1 Ras-related protein Rab-25 CATX-8 Precursor gene 1291 0.0051926145583678 DBF4 D - Genome Maintenance nucleoplasm TAS DNA replication TAS G1/S transition of mitotic cell cycle TAS cell cycle checkpoint TAS M/G1 transition of mitotic cell cycle TAS zinc ion binding IEA nucleic acid binding IEA enzyme activator activity TAS Protein DBF4 homolog A; Activator of S phase kinase; Chiffon homolog A; DBF4-type zinc finger-containing protein 1 10373557 10523313 12690205 12853948 14702039 15374998 15489334 16964243 17062569 17525332 18669648 18691976 19369195 19690332 20068231 21406692 NA DBF4A 1 Protein DBF4 homolog A Activator of S phase kinase Chiffon homolog A DBF4-type zinc finger-containing protein 1 gene 1291 0.0112275199428483 SLC6A4 D - Genome Maintenance neuron projection IEA integral to plasma membrane IC lipid raft IDA endosome membrane IEA cytosol IDA endomembrane system IDA negative regulation of organ size ISS response to hypoxia IEA response to nutrient IEA response to drug IEA negative regulation of granule cell precursor proliferation IEA response to toxin IDA protein oligomerization ISS positive regulation of progression through cell cycle IEA brain morphogenesis ISS sperm ejaculation IEA thalamus development IMP negative regulation of neuron differentiation IEA vasoconstriction IEA social behavior ISS negative regulation of synaptic transmission, dopaminergic IEA serotonin uptake IDA circadian rhythm IEA memory IEA protein homooligomerization IEA response to estradiol stimulus IEA actin filament binding ISS serotonin transporter activity IDA serotonin:sodium symporter activity IDA cocaine binding IEA Sodium-dependent serotonin transporter; 5HT transporter; 5HTT; Solute carrier family 6 member 4 10391209 12869649 12869766 14593431 15489334 15635638 16601320 16803896 16870614 17506858 17913921 18227069 19270731 21992875 7681602 7684072 8452685 NA SC6A4 -1 Sodium-dependent serotonin transporter 5HT transporter 5HTT Solute carrier family 6 member 4 gene 1291 0.0333765276045545 C - Cellular Fate and Organization nucleoplasm TAS transcription from RNA polymerase II promoter TAS parturition TAS blood coagulation TAS regulation of epidermal cell differentiation IEA embryonic development (sensu Mammalia) IEA sequence-specific DNA binding IEA transcription factor activity IEA Transcription factor MafF; U-Maf; V-maf musculoaponeurotic fibrosarcoma oncogene homolog F 10527846 10591208 11772409 14702039 15489334 16549056 NA MAFF -1 Transcription factor MafF U-Maf V-maf musculoaponeurotic fibrosarcoma oncogene homolog F gene 1291 0.0218918562607483 ROR1 C - Cellular Fate and Organization cytoplasm TAS integral to plasma membrane TAS transmembrane receptor protein tyrosine kinase signaling pathway TAS transmembrane receptor protein tyrosine kinase activity TAS ATP binding IEA Tyrosine-protein kinase transmembrane receptor ROR1; 2.7.10.1; Neurotrophic tyrosine kinase, receptor-related 1; Precursor 1334494 15489334 16710414 16959974 17344846 8875995 NA ROR1 -1 Tyrosine-protein kinase transmembrane receptor ROR1 2.7.10.1 Neurotrophic tyrosine kinase, receptor-related 1 Precursor gene 1291 0.0573568364954615 GKN2 N - Not Matched extracellular region IEA Gastrokine-2; Blottin; Down-regulated in gastric cancer; Trefoil factor interactions(z) 1; Precursor 12921637 12975309 15774165 15924415 16888721 NA GKN2 -1 Gastrokine-2 Blottin Down-regulated in gastric cancer Trefoil factor interactions(z) 1 Precursor gene 1291 1.0 MAFB T - Transcription transcription factor complex IEA nucleus TAS rhombomere 6 development IEA sensory organ development TAS rhombomere 5 development IEA inner ear morphogenesis IEA negative regulation of erythrocyte differentiation IDA respiratory gaseous exchange IEA segment specification IEA positive regulation of transcription from RNA polymerase II promoter IEA brain segmentation IEA transcription, DNA-dependent IEA sequence-specific DNA binding IEA transcription factor activity IEA transcription factor binding IDA Transcription factor MafB; Maf-B; V-maf musculoaponeurotic fibrosarcoma oncogene homolog B 10444328 11780052 14702039 15135046 15489334 15963504 18042454 19143053 22387013 NA MAFB 0 Transcription factor MafB Maf-B V-maf musculoaponeurotic fibrosarcoma oncogene homolog B TF 1291 0.00323169906125048 PDIA6 N - Not Matched melanosome IEA ER-Golgi intermediate compartment IDA plasma membrane IEA endoplasmic reticulum membrane TAS endoplasmic reticulum lumen IEA glycerol ether metabolic process IEA cell redox homeostasis IEA unfolded protein response, activation of signaling protein activity TAS protein disulfide oxidoreductase activity IEA protein disulfide isomerase activity TAS electron carrier activity IEA Protein disulfide-isomerase A6; 5.3.4.1; Endoplasmic reticulum protein 5; ER protein 5; ERp5; Protein disulfide isomerase P5; Thioredoxin domain-containing protein 7; Precursor 12204115 12475965 12643545 14702039 15466936 15489334 15815621 16964243 17081065 17081983 17495932 18318008 18669648 19690332 19892738 20068231 21269460 21406692 7590364 9110174 NA PDIA6 1 Protein disulfide-isomerase A6 5.3.4.1 Endoplasmic reticulum protein 5 ER protein 5 ERp5 Protein disulfide isomerase P5 Thioredoxin domain-containing protein 7 Precursor gene 1291 1.64211255357941E-5 D - Genome Maintenance spindle pole IEA cytoplasm IEA microtubule organizing center IEA microtubule IEA nucleus IEA cytokinesis TAS regulation of progression through mitotic cell cycle TAS spindle assembly TAS protein serine/threonine kinase activity ISS ATP binding IEA metal ion binding IEA Serine/threonine-protein kinase Nek7; 2.7.11.1; Never in mitosis A-related kinase 7; NimA-related protein kinase 7 11701951 12840024 16710414 17101132 17344846 17586473 17727698 19414596 19690332 19941817 21269460 21320329 NA NEK7 -1 Serine/threonine-protein kinase Nek7 2.7.11.1 Never in mitosis A-related kinase 7 NimA-related protein kinase 7 gene 1291 0.0617829085001869 PDIA4 F - Protein Fate melanosome IEA cell surface IDA endoplasmic reticulum lumen TAS protein secretion TAS protein folding IEA glycerol ether metabolic process IEA cell redox homeostasis IEA protein disulfide oxidoreductase activity IEA protein disulfide isomerase activity IEA electron carrier activity IEA Protein disulfide-isomerase A4; 5.3.4.1; Endoplasmic reticulum resident protein 70; ER protein 70; ERp70; Endoplasmic reticulum resident protein 72; ER protein 72; ERp-72; ERp72; Precursor 12475965 12643545 12853948 14702039 15489334 17081065 19608861 2002068 21269460 2549034 NA PDIA4 1 Protein disulfide-isomerase A4 5.3.4.1 Endoplasmic reticulum resident protein 70 ER protein 70 ERp70 Endoplasmic reticulum resident protein 72 ER protein 72 ERp-72 ERp72 Precursor gene 1291 0.00275312073119889 NEK2 D - Genome Maintenance condensed nuclear chromosome IEA spindle pole IEA centrosome IDA microtubule IEA condensed chromosome kinetochore IEA nucleolus IEA kinetochore IDA midbody IEA cytosol TAS regulation of attachment of spindle microtubules to kinetochore IMP blastocyst development IEA regulation of mitotic centrosome separation TAS spindle assembly TAS negative regulation of DNA binding IEA mitotic sister chromatid segregation IEA mitosis TAS meiosis IEA chromosome segregation IDA protein amino acid autophosphorylation IDA G2/M transition of mitotic cell cycle TAS centrosome separation IDA cell division IEA protein serine/threonine kinase activity TAS ATP binding IEA metal ion binding IEA Serine/threonine-protein kinase Nek2; 2.7.11.1; HSPK 21; Never in mitosis A-related kinase 2; NimA-related protein kinase 2; NimA-like protein kinase 1 11742531 12857871 14978040 15161910 15358203 15388344 15489334 15659832 16280549 16710414 17197699 17283141 17344846 17621308 17626005 18086858 18088087 18297113 18691976 19369195 19941817 20034488 20599736 21076410 21669869 7522034 8274451 NA NEK2 1 Serine/threonine-protein kinase Nek2 2.7.11.1 HSPK 21 Never in mitosis A-related kinase 2 NimA-related protein kinase 2 NimA-like protein kinase 1 gene 2947 1.0 ARNT C - Cellular Fate and Organization transcription factor complex IEA cytoplasm IEA nucleoplasm TAS positive regulation of vascular endothelial growth factor receptor signaling pathway IC positive regulation of endothelial cell proliferation IC positive regulation of erythrocyte differentiation IC positive regulation of hormone biosynthetic process IDA positive regulation of transcription from RNA polymerase II promoter IEA embryonic placenta development IEA regulation of transcription from RNA polymerase II promoter in response to oxidative stress IDA mRNA transcription from RNA polymerase II promoter IC positive regulation of transcription, DNA-dependent IDA positive regulation of glycolysis IC cell differentiation IEA transcription factor activity TAS transcription coactivator activity TAS aryl hydrocarbon receptor activity IEA DNA binding IEA Aryl hydrocarbon receptor nuclear translocator; ARNT protein; Class E basic helix-loop-helix protein 2; bHLHe2; Dioxin receptor, nuclear translocator; Hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta 10395741 1317062 14702039 16710414 17974005 1852076 18669648 20699359 7539918 8621524 NA ARNT 0 Aryl hydrocarbon receptor nuclear translocator ARNT protein Class E basic helix-loop-helix protein 2 bHLHe2 Dioxin receptor, nuclear translocator Hypoxia-inducible factor 1-beta HIF-1-beta HIF1-beta TF 1291 5.59962278657706E-4 COASY C - Cellular Fate and Organization nucleus IDA mitochondrial outer membrane TAS pantothenate metabolic process TAS coenzyme A biosynthetic process TAS pantetheine-phosphate adenylyltransferase activity IDA dephospho-CoA kinase activity IDA ATP binding IEA Bifunctional coenzyme A synthase; CoA synthase; NBP; POV-2; Phosphopantetheine adenylyltransferase; 2.7.7.3; Dephospho-CoA pyrophosphorylase; Pantetheine-phosphate adenylyltransferase; PPAT; Dephospho-CoA kinase; DPCK; 2.7.1.24; Dephosphocoenzyme A kinase; DPCOAK 11923312 11994049 14702039 15489334 16460672 16625196 18088087 19690332 20068231 21269460 8529999 NA COASY 1 Bifunctional coenzyme A synthase CoA synthase NBP POV-2 Phosphopantetheine adenylyltransferase 2.7.7.3 Dephospho-CoA pyrophosphorylase Pantetheine-phosphate adenylyltransferase PPAT Dephospho-CoA kinase DPCK 2.7.1.24 Dephosphocoenzyme A kinase DPCOAK gene 1291 0.0684467560661034 ARMC10 N - Not Matched mitochondrion IEA endoplasmic reticulum membrane IEA integral to membrane IEA regulation of growth IEA Armadillo repeat-containing protein 10; Splicing variant involved in hepatocarcinogenesis protein 12839973 12853948 14702039 15489334 16303743 17904127 18318008 18669648 19690332 20068231 21269460 21406692 NA ARM10 1 Armadillo repeat-containing protein 10 Splicing variant involved in hepatocarcinogenesis protein gene 1291 2.86417363433285E-4 SPP1 C - Cellular Fate and Organization perinuclear region IEA membrane-bound vesicle IEA apical part of cell IEA cell projection IEA extracellular space IDA negative regulation of collateral sprouting of intact axon in response to injury IEA decidualization TAS inflammatory response IEA embryo implantation TAS positive regulation of bone resorption IEA neutrophil chemotaxis IEA cell adhesion IEA response to steroid hormone stimulus IEA biomineral formation IEA osteoblast differentiation IEA extracellular matrix binding IEA Osteopontin; Bone sialoprotein 1; Nephropontin; Secreted phosphoprotein 1; SPP-1; Urinary stone protein; Uropontin; Precursor 14702039 15489334 1575754 15815621 15869464 16303743 16807684 1729712 1974876 20068231 21406692 22582013 23234360 2726470 2736258 7665163 7837791 7945249 NA OSTP 1 Osteopontin Bone sialoprotein 1 Nephropontin Secreted phosphoprotein 1 SPP-1 Urinary stone protein Uropontin Precursor gene 1291 0.0584361174484631 C - Cellular Fate and Organization mitochondrion IEA regulation of RNA splicing IDA protein serine/threonine kinase activity IDA ATP binding IEA Fas-activated serine/threonine kinase; FAST kinase; 2.7.11.8 12853948 14702039 15489334 17135269 17344846 7544399 NA FASTK 1 Fas-activated serine/threonine kinase FAST kinase 2.7.11.8 gene 1317 0.242471472660592 PGM2L1 N - Not Matched cytosol IBA carbohydrate catabolic process IBA glucose metabolic process IEA glucose-1,6-bisphosphate synthase activity IDA phosphoglucomutase activity IBA Glucose 1,6-bisphosphate synthase; 2.7.1.106; PMMLP; Phosphoglucomutase-2-like 1 14702039 15489334 16554811 17804405 18669648 18927083 20068231 21269460 21406692 NA PGM2L 1 Glucose 1,6-bisphosphate synthase 2.7.1.106 PMMLP Phosphoglucomutase-2-like 1 gene 1291 0.205386669791746 C - Cellular Fate and Organization plasma membrane IEA small GTPase mediated signal transduction IEA protein transport IEA GTP binding IEA Ras-related protein Rab-15 12508121 15489334 16195351 21269460 NA RAB15 1 Ras-related protein Rab-15 gene 4294 1.0 MYC D - Genome Maintenance protein complex IDA nucleolus IDA spindle IEA nucleoplasm IDA positive regulation of epithelial cell proliferation IDA negative regulation of apoptosis ISS ureteric bud branching ISS transcription initiation from RNA polymerase II promoter TAS negative regulation of fibroblast proliferation IDA positive regulation of fibroblast proliferation IDA negative regulation of transcription from RNA polymerase II promoter IDA response to DNA damage stimulus IDA oxygen transport NAS positive regulation of caspase activity IDA iron ion homeostasis IDA energy reserve metabolic process NAS Notch signaling pathway TAS negative regulation of monocyte differentiation IMP MAPKKK cascade IMP positive regulation of transcription from RNA polymerase II promoter IMP regulation of telomere maintenance IMP transforming growth factor beta receptor signaling pathway TAS cell cycle arrest IDA chromatin remodeling IDA negative regulation of cell division IDA transcription factor activity IDA protein complex binding IDA Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64 14702039 15103331 15489334 15674325 15723054 1597196 16126174 16421571 17081983 17308053 17311883 17558397 17873522 18035408 18669648 19608861 19966300 20068231 20551172 20713526 21406692 2166998 22307329 3540591 6298632 6304538 6304729 6321164 6414718 6419122 6547209 6714223 7642555 8220424 8386367 8444346 9315742 9680483 NA MYC 0 Myc proto-oncogene protein Class E basic helix-loop-helix protein 39 bHLHe39 Proto-oncogene c-Myc Transcription factor p64 TF 1291 1.0 D - Genome Maintenance nuclear matrix NAS regulation of transcription, DNA-dependent IEA thymus development IEA embryonic gut development IEA negative regulation of transcription from RNA polymerase II promoter IMP embryonic development (sensu Mammalia) IEA transcription, DNA-dependent IEA homeostasis of number of cells IEA positive regulation of histone H3-K9 methylation IMP G1/S transition of mitotic cell cycle IEA positive regulation of histone H3-K4 methylation IMP blood coagulation TAS positive regulation of transcription from RNA polymerase II promoter IDA B cell differentiation IEA chromatin remodeling IMP calcium ion transport IEA positive regulation of T-helper cell differentiation IMP transcription factor activity IEA chromatin binding IEA DNA binding IEA Transcriptional activator Myb; Proto-oncogene c-Myb 10747903 14574404 15169551 15489334 1944282 19608861 19646965 2189102 2202948 2687764 3014652 3540945 8302584 NA MYB 0 Transcriptional activator Myb Proto-oncogene c-Myb TF 1291 0.0385082947407456 IL18R1 C - Cellular Fate and Organization intracellular IEA plasma membrane TAS integral to membrane IEA signal transduction TAS immune response TAS innate immune response IEA interleukin-1 receptor activity IEA receptor activity TAS Interleukin-18 receptor 1; IL-18R-1; IL-18R1; CD218 antigen-like family member A; CDw218a; IL1 receptor-related protein; IL-1Rrp; IL1R-rp; CD218a; Precursor 14702039 15489334 15815621 8626725 9325300 NA IL18R -1 Interleukin-18 receptor 1 IL-18R-1 IL-18R1 CD218 antigen-like family member A CDw218a IL1 receptor-related protein IL-1Rrp IL1R-rp CD218a Precursor gene 1291 6.70900233782731E-4 LMNB1 C - Cellular Fate and Organization nuclear inner membrane IEA nucleoplasm IEA nuclear envelope TAS lamin filament TAS cell structure disassembly during apoptosis TAS structural molecule activity TAS Lamin-B1; Precursor 14702039 15489334 16951681 16964243 17081983 18669648 18691976 19608861 19690332 20068231 21269460 21406692 22265972 2325650 2684976 7557986 NA LMNB1 1 Lamin-B1 Precursor gene 1291 0.430071674356879 ARHGEF17 C - Cellular Fate and Organization cytosol TAS regulation of small GTPase mediated signal transduction TAS nerve growth factor receptor signaling pathway TAS actin cytoskeleton organization and biogenesis IDA small GTPase mediated signal transduction TAS regulation of Rho protein signal transduction IEA apoptosis TAS guanyl-nucleotide exchange factor activity IDA Rho guanyl-nucleotide exchange factor activity IEA Rho guanine nucleotide exchange factor 17; 164 kDa Rho-specific guanine-nucleotide exchange factor; p164-RhoGEF; p164RhoGEF; Tumor endothelial marker 4 11559528 12071859 14702039 15489334 18669648 20068231 9205841 NA ARHGH -1 Rho guanine nucleotide exchange factor 17 164 kDa Rho-specific guanine-nucleotide exchange factor p164-RhoGEF p164RhoGEF Tumor endothelial marker 4 gene 1618 0.00278826064098995 ARHGEF16 C - Cellular Fate and Organization cytosol TAS nerve growth factor receptor signaling pathway TAS small GTPase mediated signal transduction TAS apoptosis TAS phospholipid binding IEA Rho guanyl-nucleotide exchange factor activity IDA Rho guanine nucleotide exchange factor 16; Ephexin-4 15489334 16710414 18220336 18669648 19690332 20068231 20679435 21139582 21406692 NA ARHGG 1 Rho guanine nucleotide exchange factor 16 Ephexin-4 gene 1291 0.0555521932186291 ARHGEF15 C - Cellular Fate and Organization cytoplasm ISS dendrite ISS positive regulation of GTPase activity IEA regulation of Rho protein signal transduction IEA positive regulation of stress fiber formation ISS Rho guanyl-nucleotide exchange factor activity IDA GTPase activator activity IEA Rho guanine nucleotide exchange factor 15; Ephexin-5; E5; Vsm-RhoGEF 10048485 12168954 12775584 14702039 15489334 16625196 NA ARHGF -1 Rho guanine nucleotide exchange factor 15 Ephexin-5 E5 Vsm-RhoGEF gene 1291 0.00502322301819541 CXCL12 C - Cellular Fate and Organization extracellular region TAS extracellular space IEA external side of plasma membrane IEA patterning of blood vessels IEA germ cell migration IEA ameboidal cell migration IEA circulation TAS calcium ion homeostasis TAS response to virus TAS germ cell development IEA induction of positive chemotaxis IEA immune response TAS motor axon guidance IEA T cell proliferation IEA chemotaxis TAS G-protein coupled receptor protein signaling pathway TAS regulation of actin polymerization and/or depolymerization TAS brain development IEA cell adhesion TAS chemokine activity TAS CXCR chemokine receptor binding IDA Stromal cell-derived factor 1; SDF-1; hSDF-1; C-X-C motif chemokine 12; Intercrine reduced in hepatomas; IRH; hIRH; Pre-B cell growth-stimulating factor; PBSF; SDF-1-beta(3-72); SDF-1-alpha(3-67); Precursor 10446158 10954912 11069075 11859124 14525775 14702039 15164054 15489334 15588815 15741341 16107333 16626895 16725153 17264079 17357154 18799424 18802065 19255243 19551879 20077567 7490086 8752281 9384579 9427609 9618518 NA SDF1 -1 Stromal cell-derived factor 1 SDF-1 hSDF-1 C-X-C motif chemokine 12 Intercrine reduced in hepatomas IRH hIRH Pre-B cell growth-stimulating factor PBSF SDF-1-beta(3-72) SDF-1-alpha(3-67) Precursor gene 1291 0.00414069547142654 ARHGEF10 D - Genome Maintenance centrosome IDA cytosol NAS centrosome duplication IMP regulation of Rho protein signal transduction IEA myelination in the peripheral nervous system IMP positive regulation of stress fiber formation IMP Rho guanyl-nucleotide exchange factor activity IDA Rho guanine nucleotide exchange factor 10 12168954 14508709 15489334 16421571 17974005 18669648 21406692 9205841 9314494 NA ARHGA -1 Rho guanine nucleotide exchange factor 10 gene 1291 0.379666317727118 TEK C - Cellular Fate and Organization microvillus IDA cytoplasm IEA apical plasma membrane IDA basal plasma membrane IDA cell surface IDA integral to plasma membrane IDA intercellular junction IDA extracellular region IEA lipid raft IDA cytoskeleton IEA focal adhesion IEA positive regulation of protein kinase B signaling cascade IDA Tie receptor signaling pathway IDA cell-cell signaling TAS sprouting angiogenesis IMP positive regulation of phosphoinositide 3-kinase cascade IMP peptidyl-tyrosine phosphorylation IDA positive regulation of focal adhesion formation IMP leukocyte migration TAS protein oligomerization IDA positive regulation of angiogenesis IDA cell-cell adhesion IEA protein amino acid autophosphorylation IDA positive regulation of phosphoinositide 3-kinase activity IMP cell-matrix adhesion IEA positive regulation of endothelial cell proliferation TAS blood coagulation TAS negative regulation of inflammatory response TAS negative regulation of angiogenesis IMP endothelial cell proliferation ISS regulation of vascular permeability TAS positive regulation of protein amino acid phosphorylation IDA transmembrane receptor protein tyrosine kinase activity TAS ATP binding IEA Angiopoietin-1 receptor; 2.7.10.1; Endothelial tyrosine kinase; Tunica interna endothelial cell kinase; Tyrosine kinase with Ig and EGF homology domains-2; Tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor TIE-2; hTIE2; p140 TEK; CD202b; Precursor 10369874 11080633 11513602 11806244 12609966 12816861 14665640 14702039 15164053 15284220 15340161 15489334 15851516 16732286 16959974 17253678 17344846 17350837 18366015 18425119 18425120 19116766 19159218 19223473 19234476 19293632 19451274 19689429 19854647 19888299 20054809 20651738 8382358 8980225 9204896 NA TIE2 -1 Angiopoietin-1 receptor 2.7.10.1 Endothelial tyrosine kinase Tunica interna endothelial cell kinase Tyrosine kinase with Ig and EGF homology domains-2 Tyrosine-protein kinase receptor TEK Tyrosine-protein kinase receptor TIE-2 hTIE2 p140 TEK CD202b Precursor gene 1291 0.220626047024778 ESAM C - Cellular Fate and Organization plasma membrane TAS adherens junction IEA tight junction IEA integral to membrane IEA blood coagulation TAS leukocyte migration TAS homophilic cell adhesion IEA Endothelial cell-selective adhesion molecule; Precursor 11279107 12975309 14702039 15340161 15489334 19159218 NA ESAM -1 Endothelial cell-selective adhesion molecule Precursor gene 1291 0.00298885354381607 Ankyrin repeat domain-containing protein 29 14702039 15489334 16177791 16959974 NA ANR29 -1 Ankyrin repeat domain-containing protein 29 gene 1291 0.0562140580053808 RYBP T - Transcription cytoplasm IEA nucleoplasm IEA apoptosis IEA multicellular organismal development TAS negative regulation of transcription from RNA polymerase II promoter TAS transcription, DNA-dependent IEA transcription corepressor activity TAS zinc ion binding IEA DNA binding IEA RING1 and YY1-binding protein; Apoptin-associating protein 1; APAP-1; Death effector domain-associated factor; DED-associated factor; YY1 and E4TF1-associated factor 1 11395500 11953439 14765135 15489334 16943429 18669648 19098711 19690332 20068231 20696397 21269460 21406692 NA RYBP -1 RING1 and YY1-binding protein Apoptin-associating protein 1 APAP-1 Death effector domain-associated factor DED-associated factor YY1 and E4TF1-associated factor 1 gene 1291 0.0573568364954615 TPSAB1 F - Protein Fate extracellular space IDA extracellular matrix disassembly TAS proteolysis IEA defense response TAS serine-type endopeptidase activity NAS Tryptase alpha/beta-1; Tryptase-1; 3.4.21.59; Tryptase I; Tryptase alpha-1; Precursor 10898108 12162961 14670919 15489334 15616553 18039527 19159218 19748655 2187193 2677049 3543004 9920877 NA TRYB1 -1 Tryptase alpha/beta-1 Tryptase-1 3.4.21.59 Tryptase I Tryptase alpha-1 Precursor gene 1291 0.12981008547549 A - Transport and Sensing integral to membrane IEA transport IEA Solute carrier family 35 member F2 14702039 15489334 17974005 19690332 20068231 9119394 NA S35F2 1 Solute carrier family 35 member F2 gene 1291 1.08611405269208E-5 TMED3 A - Transport and Sensing COPI vesicle coat ISS ER-Golgi intermediate compartment IDA endoplasmic reticulum IDA endoplasmic reticulum membrane IEA integral to membrane IEA protein transport IEA Transmembrane emp24 domain-containing protein 3; Membrane protein p24B; p24 family protein gamma-4; p24gamma4; p26; Precursor 10852829 12237308 12975309 14702039 15489334 16572171 16940185 NA TMED3 1 Transmembrane emp24 domain-containing protein 3 Membrane protein p24B p24 family protein gamma-4 p24gamma4 p26 Precursor gene 1291 0.222686337222986 TMED2 A - Transport and Sensing ER-Golgi intermediate compartment IDA COPI coated vesicle membrane IEA zymogen granule membrane ISS COPI-coated vesicle ISS endoplasmic reticulum IDA endoplasmic reticulum membrane IEA integral to membrane ISS heart looping IEA body growth IEA maternal placenta development IEA Golgi organization and biogenesis IMP neural tube closure IEA embryonic placenta development IEA COPII coating of Golgi vesicle TAS COPI coating of Golgi vesicle TAS Transmembrane emp24 domain-containing protein 2; Membrane protein p24A; p24; p24 family protein beta-1; p24beta1; Precursor 10359607 10761932 10852829 12237308 15489334 16940185 17321752 17693410 18287528 20361938 20427317 21219331 21269460 8663407 9472029 NA TMED2 1 Transmembrane emp24 domain-containing protein 2 Membrane protein p24A p24 p24 family protein beta-1 p24beta1 Precursor gene 1291 2.71420993408912E-4 ADRB2 C - Cellular Fate and Organization receptor complex IDA apical plasma membrane IEA integral to plasma membrane IDA nucleus IEA lysosome TAS endosome TAS positive regulation of bone mineralization IEA bone resorption IEA endosome to lysosome transport TAS response to cold IEA diet induced thermogenesis IEA norepinephrine-epinephrine vasodilation during regulation of blood pressure IEA receptor-mediated endocytosis IDA arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway IDA heat generation IEA adenylate cyclase activation IDA transmembrane receptor protein tyrosine kinase activation (dimerization) TAS negative regulation of smooth muscle contraction IEA negative regulation of body size IEA brown fat cell differentiation IEA positive regulation of transcription from RNA polymerase II promoter IEA regulation of sodium ion transport IEA positive regulation of protein ubiquitination IMP G-protein signaling, coupled to cAMP nucleotide second messenger TAS G-protein signaling, adenylate cyclase activating pathway IEA positive regulation of MAPKKK cascade IDA norepinephrine binding IDA beta2-adrenergic receptor activity IDA potassium channel regulator activity IDA protein homodimerization activity IDA Beta-2 adrenergic receptor; Beta-2 adrenoreceptor; Beta-2 adrenoceptor 10499588 11146000 11246467 12142540 14702039 15489334 17525332 17952055 17962520 18547522 19424180 19584355 2540197 2823249 2831218 3025863 3026848 3033609 3034889 7706471 7822302 7915137 8383511 8521811 9388255 9924018 NA ADRB2 -1 Beta-2 adrenergic receptor Beta-2 adrenoreceptor Beta-2 adrenoceptor gene 1291 0.0385082947407456 C - Cellular Fate and Organization intermediate filament TAS fascia adherens IEA sarcolemma IEA Z disc IDA neuromuscular junction IEA cytosol TAS muscle filament sliding TAS cytoskeleton organization and biogenesis TAS regulation of heart contraction TAS structural constituent of cytoskeleton TAS Desmin 10430757 10545598 10717012 10905661 11061256 11668632 12686604 12766977 14648196 14711882 14724127 15489334 15495235 15800015 16009553 16865695 17221859 17439987 18061454 19879535 2007603 21135508 21842594 22106715 22395865 2673923 8792816 9697706 9736733 NA DESM -1 Desmin gene 1291 0.00364891215556536 ADRB1 C - Cellular Fate and Organization cytoplasm IEA integral to plasma membrane TAS nucleus IEA aging IEA response to cold IEA diet induced thermogenesis IEA norepinephrine-epinephrine vasodilation during regulation of blood pressure IEA apoptosis IEA Rho protein signal transduction IEA sensory perception of pain IEA fear response IEA positive regulation of heart contraction rate by epinephrine-norepinephrine IEA adenylate cyclase activation TAS heat generation IEA positive regulation of saliva secretion IEA negative regulation of body size IEA negative regulation of smooth muscle contraction IEA brown fat cell differentiation IEA wound healing IEA regulation of calcium ion transport IEA memory IEA G-protein signaling, adenylate cyclase activating pathway IEA glycogen catabolic process IEA norepinephrine binding IEA drug binding IEA dopamine binding IEA epinephrine binding IEA beta1-adrenergic receptor activity TAS Beta-1 adrenergic receptor; Beta-1 adrenoreceptor; Beta-1 adrenoceptor 10212248 10477438 11052857 11854867 15164054 15358775 2825170 NA ADRB1 -1 Beta-1 adrenergic receptor Beta-1 adrenoreceptor Beta-1 adrenoceptor gene 1291 0.308617760461342 CASKIN2 N - Not Matched cytoplasm ISS Caskin-2; CASK-interacting protein 2 10574461 12040031 14702039 15489334 16625196 18669648 19690332 20068231 21328705 NA CSKI2 -1 Caskin-2 CASK-interacting protein 2 gene 1365 0.00374688243165383 CD163 A - Transport and Sensing integral to plasma membrane TAS extracellular region NAS acute-phase response IEA scavenger receptor activity NAS Scavenger receptor cysteine-rich type 1 protein M130; Hemoglobin scavenger receptor; CD163; Soluble CD163; sCD163; Precursor 10066432 10403791 10577520 10648003 11196644 11298324 12208511 12296867 12377940 15075364 15448162 15478309 15489334 16335952 16434690 16541075 19159218 8370408 NA C163A 1 Scavenger receptor cysteine-rich type 1 protein M130 Hemoglobin scavenger receptor CD163 Soluble CD163 sCD163 Precursor gene 1291 0.12035157949123 NA 1 gene 1291 0.00551430130139407 CACNA2D2 A - Transport and Sensing plasma membrane TAS voltage-gated calcium channel complex IEA energy reserve metabolic process TAS positive regulation of organ size IEA regulation of insulin secretion TAS neuromuscular junction development IEA regulation of body size IEA rhythmic synaptic transmission IEA voltage-gated calcium channel activity IEA metal ion binding IEA Voltage-dependent calcium channel subunit alpha-2/delta-2; Voltage-gated calcium channel subunit alpha-2/delta-2; Voltage-dependent calcium channel subunit alpha-2-2; Voltage-dependent calcium channel subunit delta-2; Precursor 10762351 10766861 11687876 12555074 15000524 15111129 15489334 16641997 19349973 9628581 9880589 NA CA2D2 -1 Voltage-dependent calcium channel subunit alpha-2/delta-2 Voltage-gated calcium channel subunit alpha-2/delta-2 Voltage-dependent calcium channel subunit alpha-2-2 Voltage-dependent calcium channel subunit delta-2 Precursor gene 1343 0.161903634085185 BCL6 D - Genome Maintenance nucleus IDA negative regulation of cell growth IDA actin cytoskeleton organization and biogenesis IEA negative regulation of cell proliferation IEA positive regulation of B cell proliferation IEA negative regulation of Rho protein signal transduction IEA Rho protein signal transduction IEA spermatogenesis IEA negative regulation of isotype switching to IgE isotypes IEA T-helper 2 type immune response IEA regulation of memory T cell differentiation IEA negative regulation of T-helper 2 type immune response IEA negative regulation of B cell apoptosis NAS erythrocyte development IEA B cell differentiation IEA germinal center formation IEA regulation of Rho GTPase activity IEA regulation of germinal center formation NAS protein import into nucleus, translocation IGI negative regulation of mast cytokine production IEA positive regulation of apoptosis IDA regulation of inflammatory response IEA negative regulation of transcription from RNA polymerase II promoter IDA response to DNA damage stimulus IDA transcription, DNA-dependent IEA negative regulation of S phase of mitotic cell cycle NAS cell morphogenesis IEA negative regulation of T-helper 2 cell differentiation IEA positive regulation of cell motility IEA negative regulation of cell-matrix adhesion IEA sequence-specific DNA binding IDA transcription factor activity IMP chromatin binding IDA zinc ion binding IEA chromatin DNA binding IEA B-cell lymphoma 6 protein; BCL-6; B-cell lymphoma 5 protein; BCL-5; Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger protein 51 12590135 14690607 15489334 16455075 16641997 18280243 19052359 20385364 8220427 8235596 8274740 8506375 9649500 NA BCL6 -1 B-cell lymphoma 6 protein BCL-6 B-cell lymphoma 5 protein BCL-5 Protein LAZ-3 Zinc finger and BTB domain-containing protein 27 Zinc finger protein 51 TF