Savas, S., Geraci, J., Jurisica, I., Liu, G. A comprehensive catalogue of functional genetic variations in the EGFR pathway: Protein-protein interaction analysis reveals novel genes and polymorphisms important for cancer research. Int J Cancer,125(6): 1257-65, 2009.
A PPI network comprises 32 proteins and 185 interactions, highlighting subset of the core f-EGFR proteins that are highly connected to the 14 putative targets (subset of genes with functional SNPs), and the 14 proteins predicted to have an important functional connection to the EGFR pathway (14 predicted targets). Highlighted in this PPI network are cliques that interconnect both subnetworks (orange-highlighted nodes and edges; brown-highlighted nodes and edges), and cross-talk between the subnetwork (blue edges).