Cox, B., Kotlyar, M., Evangelou, A., Ignatchenko, V., Ignatchenko, A., Whiteley, K., Jurisica, I., Adamson, L., Rossant, J., Kislinger, T., Comparative systems biology of human and mouse as a tool for modeling human placental pathology, Mol Sys Bio, 5, 279, 2009.
Schematic of the cellular topology of the protein–protein interaction network. Shown are protein–protein interaction networks from I2D version 1.71, seeded with proteins that give a placental labyrinth or placental vascular phenotype when knocked out (rectangle or triangle). Proteins are colored to show cell-type expression. Node shapes indicate the placental phenotype (rectangle or triangle) or if no placental phenotype is known (oval or hexagon). Enrichment of proteins involved in extracellular matrix (yellow circle) and focal adhesion complex (blue circle) were observed (P<0.01). Other groupings are for clarity only. Eps15 and Cd82 (hexagons) are both novel members with no available knockout models. Visualization was done using NAViGaTOR version 2.15.