Projects

Current Projects

• CIHR: Are environmental factors affecting psoriatic disease sex-specific? Investigating clinical impact of the microbial metabolites in psoriatic disease
  V. Chandran and I Jurisica
  2026-2028
• Krembil Foundation: Comprehensive and Systematic Approach to Psoriatic Arthritis
  Jurisica
  2026-2029
• World Community Grid - Mapping Cancer Markers Project
  Jurisica
  2013-present
• CIHR: Unraveling Psoriatic Disease Heterogeneity Through Multi-omic Data Analysis
  V. Chandran and I Jurisica
  2024-2028
• NSERC: Towards explainable AI methods in integrative computational biology
  I Jurisica
  2024-2029
• Arthritis Society Canada: Contributions of distinct cell populations in the infrapatellar fat pad to knee osteoarthritis: Relationship with disease stage, sex and obesity
  M Kapoor, R Gandhi, I Jurisica
  2024-2027
• ERA-NET Neuron: Disease-predisposing or resilience-promoting? Decoding the systems biology and behavioural predictors and determinants of the tipping point of stress
  MB Muller, H Sork, I Hovatta, N Gassen, J Bohacek, I Jurisica
  2024-2027
• ORF: The Fibrosis Repair Team
  McCulloch, Hinz, Bozec, Jurisica, Kapus
  2023-2028
• CIHR Project Grant: Contribution of synovial fibroblast cell subsets to the pathogenesis of knee osteoarthritis
  Kapoor, Gandhi, Jurisica
  2023-2027
• The Cure Parkinson’s Trust: Repurposing rifabutin as a disease-modifying therapy for Parkinson’s disease
  L. Kalia, I. Jurisica, J. Brotchie, S. Kalia
  2022-2024
• CIHR: Diabetes Mechanisms and Translational Solutions to investigate the Central role of muscle autophagy in metabolism and musculoskeletal health
  Woo, Kapoor, Cheung, Jurisica, Wong, Usmani, Rockel
  2021-2026
• CIHR Project Grant: Identification and characterization of microRNAs essential for the development and fitness of chemoresistant AML
  Salmena, Jurisica, Gabra
  2021-2026

Past Projects

• CIHR Team Grant: Cannabis-based precision medicine for osteoarthritis therapy
  Clarke, Kapoor, Bhatia, Bonin, Davis, Fish, Furlan, Jurisica, Kotra, Zywiel, Leroux
  2020-2024
• Horizon2020-RISE: Integrative structural biology of pathological tau protein, an appealing therapeutic target for Alzheimer´s disease modifying drugs
  Zeman, Hritz
  2020-2024
• Genome Canada DIG: Interactome mapping of disease-related proteins using split intein-meidated proteinn ligation (SIMPL)
  Stagljar, Jurisica, Kislinger
  2020-2024
• Improving Outcomes by Understanding Flares in Psoriatic Arthritis: Patient-centric Approach with In-home Monitoring of Symptoms, Biomarkers and Physical Activity
  Chandran, Jurisica, Passalent, Perruccio, Kulasingam, Cameron
  2021-2023
• CIHR/Eranet: Multi-level integrative ‘omics to identify biomarkers in a Schizophrenia and other major psychoses
  Poschmann, Schulze, Jurisica
  2020-2023
• National Health and Medical Research Council of Australia: Artificial intelligence-enhanced prediction of early indicators of metastasis in lung cancer using platelet genomics
  Vafaee, Hudson, Jurisica
  2020-2023
• NSERC: Novel methods for integrative computational biology
  Jurisica
  2018-2023
• CIHR Project Grant: Identifying Metabolomic Markers of Disease Activity in Psoriatic Disease using Solid Phase Microextraction - Liquid Chromatography - High Resolution Mass Spectrometry
  Chandran, Kulasingam, Jurisica, Eder, Rosen, Cook, Boyle, Pawliszyn
  2021-2022
• CIHR Catalyst Grant: Understanding who does and does not respond to an interprofessional education and self-management model of care for chronic low back pain
  PI: Raja Rampersaud, Anthony Perruccio, Co-A: I. Jurisica, C. Veillette
  2020-2021
• CIHR Priority Funding-The Canadian Epigenetics, Environment and Health Research Consortium (CEEHRC): Role and therapeutic potential of MicroRNA-34a-5p in knee osteoarthritis
  PI: M. Kapoor, Co-A: R. Gandhi, I. Jurisica
  2020-2021
• Genome Canada: Interactome mapping of disease-related proteins using split intein-mediated protein ligation (SIMPL)
  PI: I. Stagljar, I. Jurisica, T. Kislinger
  2018-2021
• Ontario Research Fund: The Next Generation Signalling Biology Platform
  PI: I. Jurisica
  2018-2021
• Ontario Research Fund: Protein network analysis of cancer surfaceome - from interactions to drugs
  PI: I. Stagljar and I. Jurisica
  2016-2020
• National Psoriasis Foundation: Multi-omic Diagnostic Test for Psoriatic Arthritis in Psoriasis Patients
  PI: V. Chandran; Co-Is: D. Gladman, P. Rahman, L. Eder, Rosen, Jurisica, Kulasingam, R. Cook, Bansback, Boyle;
  2019-2020
• National Psoriasis Foundation: Imaging Sub-phenotypes of Psoriatic Arthritis and their Correlations with Molecular Signature – A Step Towards Precision Medicine
  PI: L. Eder; Co-Is: V. Chandran, R. Cook, I. Jurisica, P. Rahgman, I. Eshed;
  2018-2019
• CCSRI: A novel model of human brain metastasis from lung cancer: Discovering genes that regulate brain metastasis
  PI: Sheila Singh
  2016-2019
• Medicine by Design: Pathways to enhance the clinical utility of hematopoietic stem cell transplantation
  PI: J. Dick
  2016-2019
• Genome Canada: The Mammalian Membrane Two-Hybrid (MaMTH) Assay - an Advanced Proteomics Technology for Biomedical Research
  PI: I. Stagljar and I. Jurisica
  2016-2019
• Krembil Foundation: The Osteoarthritis Data Integration Platform (OADIP): Identifying and mapping genomic markers of osteoarthritis
  PI: I. Jurisica and C. Veillette
  2016-2018
• NSERC: Developing novel heuristic methods for integrative computational biology
  PI: I. Jurisica
  2013-2018
• DOD: Optimizing Early-Phase Translational Ovarian Cancer Clinical Trials with Integrative Computational Biology
  PI: A. Oza and I. Jurisica
  2012-2017
• CRC-CFI: Integrative cancer informatics
  PI: I. Jurisica
  2011-2018
• McLaughlin Centre: Development of hybrid modeling approaches for identifying multicomponent targeted therapies
  PI: I. Jurisica
  2014/15
• ORF-GL2: Cancer Gene Encyclopedia (CGEP): Computationally optimized characterization of cancer genes, proteins, their structure, function and interactions.
  PI: I. Jurisica, G. Bader, Co-applicants: L. Stein, Q. Morris
  2010-2015
• NIH: Growth Factor Receptor Signaling in Breast Cancer
  PI: MC Hung
  2010-2015
• ORF-RE: Integrated Molecular Pathology of Targeted Cancer Therapy in Lung Cancer (IMP4-Lung Cancer)
  PI: M. Tsao, I. Jurisica, Co-applicants: F. Shepherd, G. Liu, T. Kislinger, M. Moran
  April 2009-2015
• McLaughlin Centre: Cancer prevention and treatment by molecular epidemiology
  PI: I. Jurisica
  2013-2014
• CIHR: Diagnostic and prognostic biomarkers for epithelial ovarian cancer
  PI: I. Jurisica, A. Oza, Co-applicants: T. Kislinger, T. Colgan, A. Jurisicova
  2009-2014
• NIH: Development of an expert crystallization knowledge system
  PI: E Snell
  2009-2014
• World Community Grid - Help Conquer Cancer Project
  Jurisica, DeTitta, Luft, Snell, Glasgow, Fortier
  2007-2014
• CIHR: The interactome of the human G-protein coupled receptors
  PI: I. Stagljar, Co-applicants: Bouvier, Michel, Jurisica, Igor
  2011-2013
• NSERC: Techna 2012: Information and Communication Technologies for Health
  PI: I. Jurisica
  2012
• NSERC: Scalable intelligent systems for integrative analyses in computational biology
  PI: I. Jurisica
  2012-2013
• CFI LOF: Integrative computational biology for cancer genomics
  PI: I. Jurisica
  2011
• IBM International Foundation: Help Conquer Cancer
  PI: I. Jurisica
  2011
• NSERC Discovery Grants: Integrative Computational Biology
  PI: I. Jurisica
  April 1, 2007-March 31 2012
• CIHR Catalyst grant: Tools for efficient and effective network-based prediction of diagnostic and prognostic cancer signatures
  PI: I. Jurisica, Co-applicants. Drs. M.S.Tsao and I. Stagljar
  November 1, 2009-October 31, 2010
• CIHR: Maternal lethal effect and human infertility
  PI: A. Jurisicova, Co-applicants: I. Jurisica, E. Greenblat
  July 2007-July 2010
• Canada Foundation for Innovation/Ontario Research Fund: Comprehensive Systems Biology Approach to Profiling and Modeling of Cancer. A collaborative infrastructure for integrated translational research.
  PI: I. Jurisica, Principal users: Attisano, L., Bremner, R., Brown, T., Jurisica, I., Kislinger, T., Penn, L., Rottapel, R., Shaw, P., Tsao, M., Wrana, J.
  2007
• Canada Foundation for Innovation CRC/CFI/ORF Infrastructure - Integrative Computational Biology
  PI: I. Jurisica
  November 1, 2006 - October 31, 2011
• NIH - the Center for High Throughput Structural Biology (U54 GM074899-01)
  PI: G. DeTitta, Co-PIs: Mark Dumont, Mark Sullivan, Eric Phizicky, Ethan Merritt, Sol Gruner, Igor Jurisica, Mike Soltis, Mike Malkowski, Joe &nb sp; Luft, Eddie Snell, Keith Hodgson.
  July 1, 2005-2010
• Genome Canada - The Dynactome: Mapping Spatio-Temporal Dynamic Systems in Humans
  PI: T. Pawson, J. Wrana, S. Li, I. Jurisica, J. Dennis
  January, 2006 - 2009
• OICR: Identification and characterization of genetic alterations at the stromal-epithelial interface in prostate cancer.
  PI: N. Fleshner; coPIs, T. Brown, S. Done, I. Jurisica, J. Sweet
  May 2007-2010
• NSERC Strategic Grant: Intelligent monitoring, diagnosis, and rehabilitation of stroke patients.
  PI: J. Glasgow, I. Jurisica, S. Scott
  October 2006-2009
• CIHR - Defining the canonical and non-canonical WNT signaling pathways
  PI: Attisano; I. Jurisica
  July, 2005-2008
• CIHR - Endoglin, ALK-1 and BMPRII networks: Role in vascular disorders
  PI: M. Letarte; I. Jurisica; J. Wrana
  July, 2005-2010
• CIHR - Myometrial programming: A new concept underlying the control of myometrial contractility during pregnancy
  PI: S. Lye; I. Jurisica; B. Langille
  July, 2005-2010
• CIHR - Functional characterization of androgen-altered genes with a putative role during early events in ovarian carcinogenesis.
  PI: T. Brown, Co-PIs: I. Jurisica, P. Shaw, M. Letarte
  June 2005 - June 2009
• CIHR - The next generation of gene transfer therapy for human nasopharyngeal cancer.
  PI: Fei-Fei Liu, Co-PIs: I. Jurisica, R. M. Reilly
  2004-2008
• National Cancer Institute of Canada - Novel Molecular Prognostic Markers and Potential Therapeutic Targets in Non-Small Cell Lung Cancer (# 015184)
  PI: M-S Tsao; Co-PIs: I. Jurisica, W. Lam, M. Johndston, S. Der (UT), M. Pintilie, D. Wigle, F. Shepherd; Additional authors: C.-Q. Zhu, B.P. Coe, J. Liu
  2003-2008
• DOD US Army - Integrated computational biology approach to marker selection for early detection and treatment of epithelial ovarian cancer. # OC040038
  PI: I. Jurisica, Co-applicants: T. Brown, A. Oza, P. Shaw, J. Wrana
  November 15, 2004- November 15, 2007.
• NSERC Research Grant - Decision Support for Biomedical Domains
  I. Jurisica
  April 2002- March 2007
• Ontario Cancer Research Network - Genomic and proteomic biomarkers of response to treatment with small molecule epidermal growth factor receptor inhibitors in non-small cell lung cancer; OCRN 03-APR-0324
  PI: M-S Tsao, Co-PIs: I. Jurisica, F. Blackhall, W. Newman, F. Shepherd, L. K. Seymour, M. Pintilie
  September 2003- September 2006
• NIH - Northeast Structural Genomics Consortium 2- Structural Genomics of Eukaryotic Model Organisms
  PI: Gaetano Montelione, Co-PIs: Arrowsmith, Cheryl, Anderson, DeTitta, George, Edwards, Aled, Gerstein, Mark, Hendrickson, Wayne, Honig, Barry, Hunt, John, Jurisica, Igor, Kennedy, Michael A, Regan, Lynne, Rost, Burkhard, Szyperski, Thomas, Tong, Liang
  July 1, 2005- July 1, 2006
• GlaxoSmithKline – An integrated computational approach to identify important yeast proteins
  PI: I. Jurisica
  November 1, 2004-2005
• IBM SUR grant – Life Sciences Discovery Centre
  PI: I. Jurisica
  May 2005
• IRIS - Intelligent Computational Methods for the Analysis of Gene Expression Profiles
  PI: I. Jurisica, Co-PIs: J. Glasgow, R. Ng, H. Hoos
  1/2002-2005
• NIH - Northeast Structural Genomics Consortium - Structural Genomics of Eukaryotic Model Organisms
  PI: Gaetano Montelione, Co-PIs: Arrowsmith, Cheryl, Anderson, DeTitta, George, Edwards, Aled, Gerstein, Mark, Hendrickson, Wayne, Honig, Barry, Hunt, John, Jurisica, Igor, Kennedy, Michael A, Regan, Lynne, Rost, Burkhard, Szyperski, Thomas, Tong, Liang
  October 1, 2000 - August 31, 2005
• IBM SUR Grant - Integrated computational biology
  PI: I. Jurisica
  5/2003
• NSERC Strategic Grant - Knowledge Management and Decision Support for Crystal Growth
  J. Glasgow, I. Jurisica, S. Fortier, Industry collaborators: Evan Steeg of Molecular Mining Corporation; IBM Canada, Centre for Advanced Studies
  1999-2003
• IBM UPP Grant - Data mining, visualization and interpretation of high-throughput biological data
  PI: I. Jurisica
  9/2002
• IBM UPP Grant - Knowledge Management in Biological Domains
  PI: I. Jurisica
  9/2001
• IBM UPP Grant - Protein Crystallization Knowledge Management
  PI: I. Jurisica
  9/2000
• IBM SUR Grant - Decision-Support System for Crystallization Experiment Design
  PI: I. Jurisica
  12/1999
• NSERC Research Grant - Decision Support for Biomedical Domains
  PI: I. Jurisica
  3/1998-3/2002
• NSERC Equipment Grant - Molecular Scene Analysis and Macromolecular Crystallization
  J. Glasgow, S. Fortier - Queen's U, I. Jurisica - U of Toronto
  April 2000
• CITO Research Grant - Knowledge Discovery for Crystal Growth
  J. Glasgow, S. Fortier - Queen's U, I. Jurisica - U of Toronto
  April 1 2000 - March 31 2002
• NSERC Equipment Grant - Computational Techniques for Bioinformatics
  J. Glasgow, S. Fortier - Queen's U, I. Jurisica - U of Toronto
  
• CITO Research Grant - CBR: Knowledge Management and Applications
  J. Glasgow, S. Fortier - Queen's U, N. Cercone - U Waterloo, S. Matwin, R. Holte - Uof Ottawa, I. Jurisica - U of Toronto
  April 1 1998 - March 31 2000